* Fixed a bug where `eucast_rules()` would not work on a tibble when the `tibble` or `dplyr` package was loaded
* Fixed a bug where `as.ab()` would return an error on invalid input values
# AMR 1.2.0
### Breaking
### Breaking
* Removed code dependency on all other R packages, making this package fully independent of the development process of others. This is a major code change, but will probably not be noticeable by most users.
* Removed code dependency on all other R packages, making this package fully independent of the development process of others. This is a major code change, but will probably not be noticeable by most users.
@ -278,9 +278,9 @@ A methods paper about this package has been preprinted at bioRxiv (DOI: 10.1101/
<p><strong>NOTE: The WHOCC copyright does not allow use for commercial purposes, unlike any other info from this package. See <ahref="https://www.whocc.no/copyright_disclaimer/"class="uri">https://www.whocc.no/copyright_disclaimer/</a>.</strong></p>
<p><strong>NOTE: The WHOCC copyright does not allow use for commercial purposes, unlike any other info from this package. See <ahref="https://www.whocc.no/copyright_disclaimer/"class="uri">https://www.whocc.no/copyright_disclaimer/</a>.</strong></p>
<p>Read more about the data from WHOCC <ahref="./reference/WHOCC.html">in our manual</a>.</p>
<p>Read more about the data from WHOCC <ahref="./reference/WHOCC.html">in our manual</a>.</p>
<p>We support WHONET and EARS-Net data. Exported files from WHONET can be imported into R and can be analysed easily using this package. For education purposes, we created an <ahref="./reference/WHONET.html">example data set <code>WHONET</code></a> with the exact same structure as a WHONET export file. Furthermore, this package also contains a <ahref="./reference/antibiotics.html">data set antibiotics</a> with all EARS-Net antibiotic abbreviations, and knows almost all WHONET abbreviations for microorganisms. When using WHONET data as input for analysis, all input parameters will be set automatically.</p>
<p>We support WHONET and EARS-Net data. Exported files from WHONET can be imported into R and can be analysed easily using this package. For education purposes, we created an <ahref="./reference/WHONET.html">example data set <code>WHONET</code></a> with the exact same structure as a WHONET export file. Furthermore, this package also contains a <ahref="./reference/antibiotics.html">data set antibiotics</a> with all EARS-Net antibiotic abbreviations, and knows almost all WHONET abbreviations for microorganisms. When using WHONET data as input for analysis, all input parameters will be set automatically.</p>
<p>Read our tutorial about <ahref="./articles/WHONET.html">how to work with WHONET data here</a>.</p>
<p>Read our tutorial about <ahref="./articles/WHONET.html">how to work with WHONET data here</a>.</p>
<li>Fixed a bug where <code><ahref="../reference/eucast_rules.html">eucast_rules()</a></code> would not work on a tibble when the <code>tibble</code> or <code>dplyr</code> package was loaded</li>
<li>Fixed a bug where <code><ahref="../reference/as.ab.html">as.ab()</a></code> would return an error on invalid input values</li>
<p>Removed code dependency on all other R packages, making this package fully independent of the development process of others. This is a major code change, but will probably not be noticeable by most users.</p>
<p>Removed code dependency on all other R packages, making this package fully independent of the development process of others. This is a major code change, but will probably not be noticeable by most users.</p>
<p>Making this package independent of especially the tidyverse (e.g.packages <code>dplyr</code> and <code>tidyr</code>) tremendously increases sustainability on the long term, since tidyverse functions change quite often. Good for users, but hard for package maintainers. Most of our functions are replaced with versions that only rely on base R, which keeps this package fully functional for many years to come, without requiring a lot of maintenance to keep up with other packages anymore. Another upside it that this package can now be used with all versions of R since R-3.0.0 (April 2013). Our package is being used in settings where the resources are very limited. Fewer dependencies on newer software is helpful for such settings.</p>
<p>Making this package independent of especially the tidyverse (e.g.packages <code>dplyr</code> and <code>tidyr</code>) tremendously increases sustainability on the long term, since tidyverse functions change quite often. Good for users, but hard for package maintainers. Most of our functions are replaced with versions that only rely on base R, which keeps this package fully functional for many years to come, without requiring a lot of maintenance to keep up with other packages anymore. Another upside it that this package can now be used with all versions of R since R-3.0.0 (April 2013). Our package is being used in settings where the resources are very limited. Fewer dependencies on newer software is helpful for such settings.</p>
Negative effects of this change are:
<p>Negative effects of this change are:</p>
<ul>
<ul>
<li>Function <code>freq()</code> that was borrowed from the <code>cleaner</code> package was removed. Use <code><ahref="https://rdrr.io/pkg/cleaner/man/freq.html">cleaner::freq()</a></code>, or run <code><ahref="https://rdrr.io/pkg/cleaner/man">library("cleaner")</a></code> before you use <code>freq()</code>.</li>
<li>Function <code>freq()</code> that was borrowed from the <code>cleaner</code> package was removed. Use <code><ahref="https://rdrr.io/pkg/cleaner/man/freq.html">cleaner::freq()</a></code>, or run <code><ahref="https://rdrr.io/pkg/cleaner/man">library("cleaner")</a></code> before you use <code>freq()</code>.</li>
<li>Printing values of class <code>mo</code> or <code>rsi</code> in a tibble will no longer be in colour and printing <code>rsi</code> in a tibble will show the class <code><ord></code>, not <code><rsi></code> anymore. This is purely a visual effect.</li>
<li>Printing values of class <code>mo</code> or <code>rsi</code> in a tibble will no longer be in colour and printing <code>rsi</code> in a tibble will show the class <code><ord></code>, not <code><rsi></code> anymore. This is purely a visual effect.</li>
@ -250,9 +268,9 @@ Negative effects of this change are:
@ -275,7 +293,7 @@ This works for all drug combinations, such as ampicillin/sulbactam, ceftazidime/
</ul>
</ul>
</li>
</li>
<li>Added function <code><ahref="../reference/ab_property.html">ab_url()</a></code> to return the direct URL of an antimicrobial agent from the official WHO website</li>
<li>Added function <code><ahref="../reference/ab_property.html">ab_url()</a></code> to return the direct URL of an antimicrobial agent from the official WHO website</li>
<li>Improvements for algorithm in <code><ahref="../reference/as.ab.html">as.ab()</a></code>, so that e.g.<code><ahref="../reference/as.ab.html">as.ab("ampi sul")</a></code> and <code><ahref="../reference/ab_property.html">ab_name("ampi sul")</a></code> work</li>
<li>Improvements for algorithm in <code><ahref="../reference/as.ab.html">as.ab()</a></code>, so that e.g.<code><ahref="../reference/as.ab.html">as.ab("ampi sul")</a></code> and <code><ahref="../reference/ab_property.html">ab_name("ampi sul")</a></code> work</li>
<li>Functions <code><ahref="../reference/ab_property.html">ab_atc()</a></code> and <code><ahref="../reference/ab_property.html">ab_group()</a></code> now return <code>NA</code> if no antimicrobial agent could be found</li>
<li>Functions <code><ahref="../reference/ab_property.html">ab_atc()</a></code> and <code><ahref="../reference/ab_property.html">ab_group()</a></code> now return <code>NA</code> if no antimicrobial agent could be found</li>
<li>Small fix for some text input that could not be coerced as valid MIC values</li>
<li>Small fix for some text input that could not be coerced as valid MIC values</li>
<li>Fix for interpretation of generic CLSI interpretation rules (thanks to Anthony Underwood)</li>
<li>Fix for interpretation of generic CLSI interpretation rules (thanks to Anthony Underwood)</li>
@ -293,9 +311,9 @@ This works for all drug combinations, such as ampicillin/sulbactam, ceftazidime/
<li>Improvements for the algorithm used by <code><ahref="../reference/as.mo.html">as.mo()</a></code> (and consequently all <code>mo_*</code> functions, that use <code><ahref="../reference/as.mo.html">as.mo()</a></code> internally):
<li>Improvements for the algorithm used by <code><ahref="../reference/as.mo.html">as.mo()</a></code> (and consequently all <code>mo_*</code> functions, that use <code><ahref="../reference/as.mo.html">as.mo()</a></code> internally):
<ul>
<ul>
@ -335,15 +353,15 @@ This works for all drug combinations, such as ampicillin/sulbactam, ceftazidime/
<li>Fixed important floating point error for some MIC comparisons in EUCAST 2020 guideline</li>
<li><p>Fixed important floating point error for some MIC comparisons in EUCAST 2020 guideline</p></li>
<li>
<li>
<p>Interpretation from MIC values (and disk zones) to R/SI can now be used with <code><ahref="https://dplyr.tidyverse.org/reference/mutate_all.html">mutate_at()</a></code> of the <code>dplyr</code> package:</p>
<p>Interpretation from MIC values (and disk zones) to R/SI can now be used with <code><ahref="https://dplyr.tidyverse.org/reference/mutate_all.html">mutate_at()</a></code> of the <code>dplyr</code> package:</p>
<li>Added antibiotic abbreviations for a laboratory manufacturer (GLIMS) for cefuroxime, cefotaxime, ceftazidime, cefepime, cefoxitin and trimethoprim/sulfamethoxazole</li>
<li><p>Added antibiotic abbreviations for a laboratory manufacturer (GLIMS) for cefuroxime, cefotaxime, ceftazidime, cefepime, cefoxitin and trimethoprim/sulfamethoxazole</p></li>
<li>Added <code>uti</code> (as abbreviation of urinary tract infections) as parameter to <code><ahref="../reference/as.rsi.html">as.rsi()</a></code>, so interpretation of MIC values and disk zones can be made dependent on isolates specifically from UTIs</li>
<li><p>Added <code>uti</code> (as abbreviation of urinary tract infections) as parameter to <code><ahref="../reference/as.rsi.html">as.rsi()</a></code>, so interpretation of MIC values and disk zones can be made dependent on isolates specifically from UTIs</p></li>
<li><p>Info printing in functions <code><ahref="../reference/eucast_rules.html">eucast_rules()</a></code>, <code><ahref="../reference/first_isolate.html">first_isolate()</a></code>, <code><ahref="../reference/mdro.html">mdro()</a></code> and <code><ahref="../reference/resistance_predict.html">resistance_predict()</a></code> will now at default only print when R is in an interactive mode (i.e.not in RMarkdown)</p></li>
<li><p>Info printing in functions <code><ahref="../reference/eucast_rules.html">eucast_rules()</a></code>, <code><ahref="../reference/first_isolate.html">first_isolate()</a></code>, <code><ahref="../reference/mdro.html">mdro()</a></code> and <code><ahref="../reference/resistance_predict.html">resistance_predict()</a></code> will now at default only print when R is in an interactive mode (i.e.not in RMarkdown)</p></li>
<p>This software is now out of beta and considered stable. Nonetheless, this package will be developed continually.</p>
<p>This software is now out of beta and considered stable. Nonetheless, this package will be developed continually.</p>
<divid="new-1"class="section level3">
<divid="new-1"class="section level3">
@ -417,7 +435,7 @@ This works for all drug combinations, such as ampicillin/sulbactam, ceftazidime/
<li>Changes to the <code>antibiotics</code> data set (thanks to Peter Dutey):
<li>Changes to the <code>antibiotics</code> data set (thanks to Peter Dutey):
<ul>
<ul>
<li>Added more synonyms to colistin, imipenem and piperacillin/tazobactam</li>
<li>Added more synonyms to colistin, imipenem and piperacillin/tazobactam</li>
<li>Moved synonyms Rifinah and Rimactazid from rifampicin (<code>RIF</code>) to rifampicin/isoniazid (<code>RFI</code>). Please note that <ahref="https://www.whocc.no/atc_ddd_index/?code=J04AM02&showdescription=no">the combination rifampicin/isoniazid has no DDDs defined</a>, so e.g.<code><ahref="../reference/ab_property.html">ab_ddd("Rimactazid")</a></code> will now return <code>NA</code>.</li>
<li>Moved synonyms Rifinah and Rimactazid from rifampicin (<code>RIF</code>) to rifampicin/isoniazid (<code>RFI</code>). Please note that <ahref="https://www.whocc.no/atc_ddd_index/?code=J04AM02&showdescription=no">the combination rifampicin/isoniazid has no DDDs defined</a>, so e.g.<code><ahref="../reference/ab_property.html">ab_ddd("Rimactazid")</a></code> will now return <code>NA</code>.</li>
<li>Moved synonyms Bactrimel and Cotrimazole from sulfamethoxazole (<code>SMX</code>) to trimethoprim/sulfamethoxazole (<code>SXT</code>)</li>
<li>Moved synonyms Bactrimel and Cotrimazole from sulfamethoxazole (<code>SMX</code>) to trimethoprim/sulfamethoxazole (<code>SXT</code>)</li>
</ul>
</ul>
</li>
</li>
@ -433,9 +451,9 @@ This works for all drug combinations, such as ampicillin/sulbactam, ceftazidime/
<li>Support for a new MDRO guideline: Magiorakos AP, Srinivasan A <em>et al.</em> “Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance.” Clinical Microbiology and Infection (2012).
<li>
<p>Support for a new MDRO guideline: Magiorakos AP, Srinivasan A <em>et al.</em> “Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance.” Clinical Microbiology and Infection (2012).</p>
<ul>
<ul>
<li>This is now the new default guideline for the <code><ahref="../reference/mdro.html">mdro()</a></code> function</li>
<li>This is now the new default guideline for the <code><ahref="../reference/mdro.html">mdro()</a></code> function</li>
<li>The new Verbose mode (<code><ahref="../reference/mdro.html">mdro(...., verbose = TRUE)</a></code>) returns an informative data set where the reason for MDRO determination is given for every isolate, and an list of the resistant antimicrobial agents</li>
<li>The new Verbose mode (<code><ahref="../reference/mdro.html">mdro(...., verbose = TRUE)</a></code>) returns an informative data set where the reason for MDRO determination is given for every isolate, and an list of the resistant antimicrobial agents</li>
@ -481,8 +500,8 @@ This works for all drug combinations, such as ampicillin/sulbactam, ceftazidime/
<ul>
<ul>
<li>Improvements to algorithm in <code><ahref="../reference/as.mo.html">as.mo()</a></code>:
<li>Improvements to algorithm in <code><ahref="../reference/as.mo.html">as.mo()</a></code>:
<ul>
<ul>
<li>Now allows “ou” where “au” should have been used and vice versa</li>
<li><p>Now allows “ou” where “au” should have been used and vice versa</p></li>
<li>More intelligent way of coping with some consonants like “l” and “r”</li>
<li><p>More intelligent way of coping with some consonants like “l” and “r”</p></li>
<li>
<li>
<p>Added a score (a certainty percentage) to <code><ahref="../reference/as.mo.html">mo_uncertainties()</a></code>, that is calculated using the <ahref="https://en.wikipedia.org/wiki/Levenshtein_distance">Levenshtein distance</a>:</p>
<p>Added a score (a certainty percentage) to <code><ahref="../reference/as.mo.html">mo_uncertainties()</a></code>, that is calculated using the <ahref="https://en.wikipedia.org/wiki/Levenshtein_distance">Levenshtein distance</a>:</p>
@ -543,7 +562,8 @@ This works for all drug combinations, such as ampicillin/sulbactam, ceftazidime/
<li>
<li>
<p>Determination of first isolates now <strong>excludes</strong> all ‘unknown’ microorganisms at default, i.e.microbial code <code>"UNKNOWN"</code>. They can be included with the new parameter <code>include_unknown</code>:</p>
<p>Determination of first isolates now <strong>excludes</strong> all ‘unknown’ microorganisms at default, i.e.microbial code <code>"UNKNOWN"</code>. They can be included with the new parameter <code>include_unknown</code>:</p>
For WHONET users, this means that all records/isolates with organism code <code>"con"</code> (<em>contamination</em>) will be excluded at default, since <code>as.mo("con") = "UNKNOWN"</code>. The function always shows a note with the number of ‘unknown’ microorganisms that were included or excluded.</li>
<p>For WHONET users, this means that all records/isolates with organism code <code>"con"</code> (<em>contamination</em>) will be excluded at default, since <code>as.mo("con") = "UNKNOWN"</code>. The function always shows a note with the number of ‘unknown’ microorganisms that were included or excluded.</p>
</li>
<li>
<li>
<p>For code consistency, classes <code>ab</code> and <code>mo</code> will now be preserved in any subsetting or assignment. For the sake of data integrity, this means that invalid assignments will now result in <code>NA</code>:</p>
<p>For code consistency, classes <code>ab</code> and <code>mo</code> will now be preserved in any subsetting or assignment. For the sake of data integrity, this means that invalid assignments will now result in <code>NA</code>:</p>
<divclass="sourceCode"id="cb9"><preclass="r"><spanclass="co"># how it works in base R:</span>
<divclass="sourceCode"id="cb9"><preclass="r"><spanclass="co"># how it works in base R:</span>
@ -557,8 +577,9 @@ For WHONET users, this means that all records/isolates with organism code <code>
<spanclass="co">#> invalid microorganism code, NA generated</span></pre></div>
<spanclass="co">#> invalid microorganism code, NA generated</span></pre></div>
This is important, because a value like <code>"testvalue"</code> could never be understood by e.g. <code><ahref="../reference/mo_property.html">mo_name()</a></code>, although the class would suggest a valid microbial code.</li>
<p>This is important, because a value like <code>"testvalue"</code> could never be understood by e.g.<code><ahref="../reference/mo_property.html">mo_name()</a></code>, although the class would suggest a valid microbial code.</p>
<li>Function <code>freq()</code> has moved to a new package, <ahref="https://github.com/msberends/clean"><code>clean</code></a> (<ahref="https://cran.r-project.org/package=clean">CRAN link</a>), since creating frequency tables actually does not fit the scope of this package. The <code>freq()</code> function still works, since it is re-exported from the <code>clean</code> package (which will be installed automatically upon updating this <code>AMR</code> package).</li>
</li>
<li><p>Function <code>freq()</code> has moved to a new package, <ahref="https://github.com/msberends/clean"><code>clean</code></a> (<ahref="https://cran.r-project.org/package=clean">CRAN link</a>), since creating frequency tables actually does not fit the scope of this package. The <code>freq()</code> function still works, since it is re-exported from the <code>clean</code> package (which will be installed automatically upon updating this <code>AMR</code> package).</p></li>
<li><p>Renamed data set <code>septic_patients</code> to <code>example_isolates</code></p></li>
<li><p>Renamed data set <code>septic_patients</code> to <code>example_isolates</code></p></li>
</ul>
</ul>
</div>
</div>
@ -609,7 +630,8 @@ This is important, because a value like <code>"testvalue"</code> could never be
Since this is a major change, usage of the old <code>also_single_tested</code> will throw an informative error that it has been replaced by <code>only_all_tested</code>.</li>
<p>Since this is a major change, usage of the old <code>also_single_tested</code> will throw an informative error that it has been replaced by <code>only_all_tested</code>.</p>
</li>
<li>
<li>
<p><code>tibble</code> printing support for classes <code>rsi</code>, <code>mic</code>, <code>disk</code>, <code>ab</code><code>mo</code>. When using <code>tibble</code>s containing antimicrobial columns, values <code>S</code> will print in green, values <code>I</code> will print in yellow and values <code>R</code> will print in red. Microbial IDs (class <code>mo</code>) will emphasise on the genus and species, not on the kingdom.</p>
<p><code>tibble</code> printing support for classes <code>rsi</code>, <code>mic</code>, <code>disk</code>, <code>ab</code><code>mo</code>. When using <code>tibble</code>s containing antimicrobial columns, values <code>S</code> will print in green, values <code>I</code> will print in yellow and values <code>R</code> will print in red. Microbial IDs (class <code>mo</code>) will emphasise on the genus and species, not on the kingdom.</p>
<divclass="sourceCode"id="cb13"><preclass="r"><spanclass="co"># (run this on your own console, as this page does not support colour printing)</span>
<divclass="sourceCode"id="cb13"><preclass="r"><spanclass="co"># (run this on your own console, as this page does not support colour printing)</span>
@ -620,9 +642,9 @@ Since this is a major change, usage of the old <code>also_single_tested</code> w
<li>Many algorithm improvements for <code><ahref="../reference/as.mo.html">as.mo()</a></code> (of which some led to additions to the <code>microorganisms</code> data set). Many thanks to all contributors that helped improving the algorithms.
<li>Many algorithm improvements for <code><ahref="../reference/as.mo.html">as.mo()</a></code> (of which some led to additions to the <code>microorganisms</code> data set). Many thanks to all contributors that helped improving the algorithms.
<ul>
<ul>
@ -646,7 +668,7 @@ Since this is a major change, usage of the old <code>also_single_tested</code> w
</li>
</li>
<li>Added more informative errors and warnings</li>
<li>Added more informative errors and warnings</li>
<li>Printed info now distinguishes between added and changes values</li>
<li>Printed info now distinguishes between added and changes values</li>
<li>Using Verbose mode (i.e.<code><ahref="../reference/eucast_rules.html">eucast_rules(..., verbose = TRUE)</a></code>) returns more informative and readable output</li>
<li>Using Verbose mode (i.e.<code><ahref="../reference/eucast_rules.html">eucast_rules(..., verbose = TRUE)</a></code>) returns more informative and readable output</li>
<li>Using factors as input now adds missing factors levels when the function changes antibiotic results</li>
<li>Using factors as input now adds missing factors levels when the function changes antibiotic results</li>
</ul>
</ul>
</li>
</li>
@ -683,9 +705,9 @@ Since this is a major change, usage of the old <code>also_single_tested</code> w
<li>Function <code><ahref="../reference/mo_property.html">mo_info()</a></code> as an analogy to <code><ahref="../reference/ab_property.html">ab_info()</a></code>. The <code><ahref="../reference/mo_property.html">mo_info()</a></code> prints a list with the full taxonomy, authors, and the URL to the online database of a microorganism</li>
<li><p>Function <code><ahref="../reference/mo_property.html">mo_info()</a></code> as an analogy to <code><ahref="../reference/ab_property.html">ab_info()</a></code>. The <code><ahref="../reference/mo_property.html">mo_info()</a></code> prints a list with the full taxonomy, authors, and the URL to the online database of a microorganism</p></li>
<li><p>Function <code><ahref="../reference/mo_property.html">mo_synonyms()</a></code> to get all previously accepted taxonomic names of a microorganism</p></li>
<li><p>Function <code><ahref="../reference/mo_property.html">mo_synonyms()</a></code> to get all previously accepted taxonomic names of a microorganism</p></li>
<li>Column names of output <code><ahref="../reference/count.html">count_df()</a></code> and <code><ahref="../reference/AMR-deprecated.html">portion_df()</a></code> are now lowercase</li>
<li>Column names of output <code><ahref="../reference/count.html">count_df()</a></code> and <code><ahref="../reference/AMR-deprecated.html">portion_df()</a></code> are now lowercase</li>
<li>Fixed bug in translation of microorganism names</li>
<li>Fixed bug in translation of microorganism names</li>
@ -764,9 +786,9 @@ Since this is a major change, usage of the old <code>also_single_tested</code> w
@ -778,48 +800,51 @@ Since this is a major change, usage of the old <code>also_single_tested</code> w
<li>Added guidelines of the WHO to determine multi-drug resistance (MDR) for TB (<code><ahref="../reference/mdro.html">mdr_tb()</a></code>) and added a new vignette about MDR. Read this tutorial <ahref="https://msberends.gitlab.io/AMR/articles/MDR.html">here on our website</a>.</li>
<li>Added guidelines of the WHO to determine multi-drug resistance (MDR) for TB (<code><ahref="../reference/mdro.html">mdr_tb()</a></code>) and added a new vignette about MDR. Read this tutorial <ahref="https://msberends.gitlab.io/AMR/articles/MDR.html">here on our website</a>.</li>
<li>Fixed a critical bug in <code><ahref="../reference/first_isolate.html">first_isolate()</a></code> where missing species would lead to incorrect FALSEs. This bug was not present in AMR v0.5.0, but was in v0.6.0 and v0.6.1.</li>
<li><p>Fixed a critical bug in <code><ahref="../reference/first_isolate.html">first_isolate()</a></code> where missing species would lead to incorrect FALSEs. This bug was not present in AMR v0.5.0, but was in v0.6.0 and v0.6.1.</p></li>
<li>Fixed a bug in <code><ahref="../reference/eucast_rules.html">eucast_rules()</a></code> where antibiotics from WHONET software would not be recognised</li>
<li><p>Fixed a bug in <code><ahref="../reference/eucast_rules.html">eucast_rules()</a></code> where antibiotics from WHONET software would not be recognised</p></li>
<li>Completely reworked the <code>antibiotics</code> data set:
<li>
<p>Completely reworked the <code>antibiotics</code> data set:</p>
<ul>
<ul>
<li>All entries now have 3 different identifiers:
<li>
<p>All entries now have 3 different identifiers:</p>
<ul>
<ul>
<li>Column <code>ab</code> contains a human readable EARS-Net code, used by ECDC and WHO/WHONET - this is the primary identifier used in this package</li>
<li>Column <code>ab</code> contains a human readable EARS-Net code, used by ECDC and WHO/WHONET - this is the primary identifier used in this package</li>
<li>Column <code>atc</code> contains the ATC code, used by WHO/WHOCC</li>
<li>Column <code>atc</code> contains the ATC code, used by WHO/WHOCC</li>
<li>Column <code>cid</code> contains the CID code (Compound ID), used by PubChem</li>
<li>Column <code>cid</code> contains the CID code (Compound ID), used by PubChem</li>
</ul>
</ul>
</li>
</li>
<li>Based on the Compound ID, almost 5,000 official brand names have been added from many different countries</li>
<li><p>Based on the Compound ID, almost 5,000 official brand names have been added from many different countries</p></li>
<li>All references to antibiotics in our package now use EARS-Net codes, like <code>AMX</code> for amoxicillin</li>
<li><p>All references to antibiotics in our package now use EARS-Net codes, like <code>AMX</code> for amoxicillin</p></li>
<li>Functions <code>atc_certe</code>, <code>ab_umcg</code> and <code>atc_trivial_nl</code> have been removed</li>
<li><p>Functions <code>atc_certe</code>, <code>ab_umcg</code> and <code>atc_trivial_nl</code> have been removed</p></li>
<li>All <code>atc_*</code> functions are superceded by <code>ab_*</code> functions</li>
<li><p>All <code>atc_*</code> functions are superceded by <code>ab_*</code> functions</p></li>
<li>
<li>
<p>All output will be translated by using an included translation file which <ahref="https://gitlab.com/msberends/AMR/blob/master/data-raw/translations.tsv">can be viewed here</a>.</p>
<p>All output will be translated by using an included translation file which <ahref="https://gitlab.com/msberends/AMR/blob/master/data-raw/translations.tsv">can be viewed here</a>.</p>
Please <ahref="https://gitlab.com/msberends/AMR/issues/new?issue%5Btitle%5D=Translation%20suggestion">create an issue in one of our repositories</a> if you want additions in this file.</li>
<p>Please <ahref="https://gitlab.com/msberends/AMR/issues/new?issue%5Btitle%5D=Translation%20suggestion">create an issue in one of our repositories</a> if you want additions in this file.</p>
</li>
</ul>
</ul>
</li>
</li>
<li>Improvements to plotting AMR results with <code><ahref="../reference/ggplot_rsi.html">ggplot_rsi()</a></code>:
<li>
<p>Improvements to plotting AMR results with <code><ahref="../reference/ggplot_rsi.html">ggplot_rsi()</a></code>:</p>
<ul>
<ul>
<li>New parameter <code>colours</code> to set the bar colours</li>
<li>New parameter <code>colours</code> to set the bar colours</li>
<li>New parameters <code>title</code>, <code>subtitle</code>, <code>caption</code>, <code>x.title</code> and <code>y.title</code> to set titles and axis descriptions</li>
<li>New parameters <code>title</code>, <code>subtitle</code>, <code>caption</code>, <code>x.title</code> and <code>y.title</code> to set titles and axis descriptions</li>
</ul>
</ul>
</li>
</li>
<li>Improved intelligence of looking up antibiotic columns in a data set using <code><ahref="../reference/guess_ab_col.html">guess_ab_col()</a></code>
<li><p>Improved intelligence of looking up antibiotic columns in a data set using <code><ahref="../reference/guess_ab_col.html">guess_ab_col()</a></code></p></li>
</li>
<li><p>Added ~5,000 more old taxonomic names to the <code>microorganisms.old</code> data set, which leads to better results finding when using the <code><ahref="../reference/as.mo.html">as.mo()</a></code> function</p></li>
<li>Added ~5,000 more old taxonomic names to the <code>microorganisms.old</code> data set, which leads to better results finding when using the <code><ahref="../reference/as.mo.html">as.mo()</a></code> function</li>
<li><p>This package now honours the new EUCAST insight (2019) that S and I are but classified as susceptible, where I is defined as ‘increased exposure’ and not ‘intermediate’ anymore. For functions like <code><ahref="../reference/AMR-deprecated.html">portion_df()</a></code> and <code><ahref="../reference/count.html">count_df()</a></code> this means that their new parameter <code>combine_SI</code> is TRUE at default. Our plotting function <code><ahref="../reference/ggplot_rsi.html">ggplot_rsi()</a></code> also reflects this change since it uses <code><ahref="../reference/count.html">count_df()</a></code> internally.</p></li>
<li>This package now honours the new EUCAST insight (2019) that S and I are but classified as susceptible, where I is defined as ‘increased exposure’ and not ‘intermediate’ anymore. For functions like <code><ahref="../reference/AMR-deprecated.html">portion_df()</a></code> and <code><ahref="../reference/count.html">count_df()</a></code> this means that their new parameter <code>combine_SI</code> is TRUE at default. Our plotting function <code><ahref="../reference/ggplot_rsi.html">ggplot_rsi()</a></code> also reflects this change since it uses <code><ahref="../reference/count.html">count_df()</a></code> internally.</li>
<li><p>The <code><ahref="../reference/age.html">age()</a></code> function gained a new parameter <code>exact</code> to determine ages with decimals</p></li>
<li>The <code><ahref="../reference/age.html">age()</a></code> function gained a new parameter <code>exact</code> to determine ages with decimals</li>
<p>Removed all hardcoded EUCAST rules and replaced them with a new reference file which <ahref="https://gitlab.com/msberends/AMR/blob/master/data-raw/eucast_rules.tsv">can be viewed here</a>.</p>
<p>Removed all hardcoded EUCAST rules and replaced them with a new reference file which <ahref="https://gitlab.com/msberends/AMR/blob/master/data-raw/eucast_rules.tsv">can be viewed here</a>.</p>
Please <ahref="https://gitlab.com/msberends/AMR/issues/new?issue%5Btitle%5D=EUCAST%20edit">create an issue in one of our repositories</a> if you want changes in this file.</li>
<p>Please <ahref="https://gitlab.com/msberends/AMR/issues/new?issue%5Btitle%5D=EUCAST%20edit">create an issue in one of our repositories</a> if you want changes in this file.</p>
<li>Added ceftazidim intrinsic resistance to <em>Streptococci</em>
</li>
</li>
<li>Changed default settings for <code><ahref="../reference/age_groups.html">age_groups()</a></code>, to let groups of fives and tens end with 100+ instead of 120+</li>
<li><p>Added ceftazidim intrinsic resistance to <em>Streptococci</em></p></li>
<li>Fix for <code>freq()</code> for when all values are <code>NA</code>
<li><p>Changed default settings for <code><ahref="../reference/age_groups.html">age_groups()</a></code>, to let groups of fives and tens end with 100+ instead of 120+</p></li>
</li>
<li><p>Fix for <code>freq()</code> for when all values are <code>NA</code></p></li>
<li>Fix for <code><ahref="../reference/first_isolate.html">first_isolate()</a></code> for when dates are missing</li>
<li><p>Fix for <code><ahref="../reference/first_isolate.html">first_isolate()</a></code> for when dates are missing</p></li>
<li>Improved speed of <code><ahref="../reference/guess_ab_col.html">guess_ab_col()</a></code>
<li><p>Improved speed of <code><ahref="../reference/guess_ab_col.html">guess_ab_col()</a></code></p></li>
</li>
<li><p>Function <code><ahref="../reference/as.mo.html">as.mo()</a></code> now gently interprets any number of whitespace characters (like tabs) as one space</p></li>
<li>Function <code><ahref="../reference/as.mo.html">as.mo()</a></code> now gently interprets any number of whitespace characters (like tabs) as one space</li>
<li><p>Function <code><ahref="../reference/as.mo.html">as.mo()</a></code> now returns <code>UNKNOWN</code> for <code>"con"</code> (WHONET ID of ‘contamination’) and returns <code>NA</code> for <code>"xxx"</code>(WHONET ID of ‘no growth’)</p></li>
<li>Function <code><ahref="../reference/as.mo.html">as.mo()</a></code> now returns <code>UNKNOWN</code> for <code>"con"</code> (WHONET ID of ‘contamination’) and returns <code>NA</code> for <code>"xxx"</code>(WHONET ID of ‘no growth’)</li>
<li><p>Small algorithm fix for <code><ahref="../reference/as.mo.html">as.mo()</a></code></p></li>
<li>Small algorithm fix for <code><ahref="../reference/as.mo.html">as.mo()</a></code>
<li><p>Removed viruses from data set <code>microorganisms.codes</code> and cleaned it up</p></li>
</li>
<li>Removed viruses from data set <code>microorganisms.codes</code> and cleaned it up</li>
<li><p>Fix for <code><ahref="../reference/mo_property.html">mo_shortname()</a></code> where species would not be determined correctly</p></li>
<li><p>Fix for <code><ahref="../reference/mo_property.html">mo_shortname()</a></code> where species would not be determined correctly</p></li>
<p>We’ve got a new website: <ahref="https://msberends.gitlab.io/AMR/">https://msberends.gitlab.io/AMR</a> (built with the great <ahref="https://pkgdown.r-lib.org/"><code>pkgdown</code></a>)</p>
<p>We’ve got a new website: <ahref="https://msberends.gitlab.io/AMR/">https://msberends.gitlab.io/AMR</a> (built with the great <ahref="https://pkgdown.r-lib.org/"><code>pkgdown</code></a>)</p>
<li><p><strong>BREAKING</strong>: removed deprecated functions, parameters and references to ‘bactid’. Use <code><ahref="../reference/as.mo.html">as.mo()</a></code> to identify an MO code.</p></li>
<li>
<li>
<strong>BREAKING</strong>: removed deprecated functions, parameters and references to ‘bactid’. Use <code><ahref="../reference/as.mo.html">as.mo()</a></code> to identify an MO code.</li>
<p>Catalogue of Life as a new taxonomic source for data about microorganisms, which also contains all ITIS data we used previously. The <code>microorganisms</code> data set now contains:</p>
<li>Catalogue of Life as a new taxonomic source for data about microorganisms, which also contains all ITIS data we used previously. The <code>microorganisms</code> data set now contains:
<ul>
<ul>
<li>All ~55,000 (sub)species from the kingdoms of Archaea, Bacteria and Protozoa</li>
<li><p>All ~55,000 (sub)species from the kingdoms of Archaea, Bacteria and Protozoa</p></li>
<li>All ~3,000 (sub)species from these orders of the kingdom of Fungi: Eurotiales, Onygenales, Pneumocystales, Saccharomycetales and Schizosaccharomycetales (covering at least like all species of <em>Aspergillus</em>, <em>Candida</em>, <em>Pneumocystis</em>, <em>Saccharomyces</em> and <em>Trichophyton</em>)</li>
<li><p>All ~3,000 (sub)species from these orders of the kingdom of Fungi: Eurotiales, Onygenales, Pneumocystales, Saccharomycetales and Schizosaccharomycetales (covering at least like all species of <em>Aspergillus</em>, <em>Candida</em>, <em>Pneumocystis</em>, <em>Saccharomyces</em> and <em>Trichophyton</em>)</p></li>
<li>All ~2,000 (sub)species from ~100 other relevant genera, from the kingdoms of Animalia and Plantae (like <em>Strongyloides</em> and <em>Taenia</em>)</li>
<li><p>All ~2,000 (sub)species from ~100 other relevant genera, from the kingdoms of Animalia and Plantae (like <em>Strongyloides</em> and <em>Taenia</em>)</p></li>
<li>All ~15,000 previously accepted names of included (sub)species that have been taxonomically renamed</li>
<li><p>All ~15,000 previously accepted names of included (sub)species that have been taxonomically renamed</p></li>
<li>
<li>
<p>The responsible author(s) and year of scientific publication</p>
<p>The responsible author(s) and year of scientific publication</p>
This data is updated annually - check the included version with the new function <code><ahref="../reference/catalogue_of_life_version.html">catalogue_of_life_version()</a></code>.</li>
<p>This data is updated annually - check the included version with the new function <code><ahref="../reference/catalogue_of_life_version.html">catalogue_of_life_version()</a></code>.</p>
<li>Due to this change, some <code>mo</code> codes changed (e.g. <em>Streptococcus</em> changed from <code>B_STRPTC</code> to <code>B_STRPT</code>). A translation table is used internally to support older microorganism IDs, so users will not notice this difference.</li>
</li>
<li>New function <code><ahref="../reference/mo_property.html">mo_rank()</a></code> for the taxonomic rank (genus, species, infraspecies, etc.)</li>
<li><p>Due to this change, some <code>mo</code> codes changed (e.g.<em>Streptococcus</em> changed from <code>B_STRPTC</code> to <code>B_STRPT</code>). A translation table is used internally to support older microorganism IDs, so users will not notice this difference.</p></li>
<li>New function <code><ahref="../reference/mo_property.html">mo_url()</a></code> to get the direct URL of a species from the Catalogue of Life</li>
<li><p>New function <code><ahref="../reference/mo_property.html">mo_rank()</a></code> for the taxonomic rank (genus, species, infraspecies, etc.)</p></li>
<li><p>New function <code><ahref="../reference/mo_property.html">mo_url()</a></code> to get the direct URL of a species from the Catalogue of Life</p></li>
</ul>
</ul>
</li>
</li>
<li>Support for data from <ahref="https://whonet.org/">WHONET</a> and <ahref="https://ecdc.europa.eu/en/about-us/partnerships-and-networks/disease-and-laboratory-networks/ears-net">EARS-Net</a> (European Antimicrobial Resistance Surveillance Network):
<li>
<p>Support for data from <ahref="https://whonet.org/">WHONET</a> and <ahref="https://ecdc.europa.eu/en/about-us/partnerships-and-networks/disease-and-laboratory-networks/ears-net">EARS-Net</a> (European Antimicrobial Resistance Surveillance Network):</p>
<ul>
<ul>
<li>Exported files from WHONET can be read and used in this package. For functions like <code><ahref="../reference/first_isolate.html">first_isolate()</a></code> and <code><ahref="../reference/eucast_rules.html">eucast_rules()</a></code>, all parameters will be filled in automatically.</li>
<li>Exported files from WHONET can be read and used in this package. For functions like <code><ahref="../reference/first_isolate.html">first_isolate()</a></code> and <code><ahref="../reference/eucast_rules.html">eucast_rules()</a></code>, all parameters will be filled in automatically.</li>
<li>This package now knows all antibiotic abbrevations by EARS-Net (which are also being used by WHONET) - the <code>antibiotics</code> data set now contains a column <code>ears_net</code>.</li>
<li>This package now knows all antibiotic abbrevations by EARS-Net (which are also being used by WHONET) - the <code>antibiotics</code> data set now contains a column <code>ears_net</code>.</li>
@ -940,15 +964,16 @@ This data is updated annually - check the included version with the new function
These functions use <code>as.atc()</code> internally. The old <code>atc_property</code> has been renamed <code><ahref="../reference/atc_online.html">atc_online_property()</a></code>. This is done for two reasons: firstly, not all ATC codes are of antibiotics (ab) but can also be of antivirals or antifungals. Secondly, the input must have class <code>atc</code> or must be coerable to this class. Properties of these classes should start with the same class name, analogous to <code><ahref="../reference/as.mo.html">as.mo()</a></code> and e.g. <code>mo_genus</code>.</li>
<p>These functions use <code>as.atc()</code> internally. The old <code>atc_property</code> has been renamed <code><ahref="../reference/atc_online.html">atc_online_property()</a></code>. This is done for two reasons: firstly, not all ATC codes are of antibiotics (ab) but can also be of antivirals or antifungals. Secondly, the input must have class <code>atc</code> or must be coerable to this class. Properties of these classes should start with the same class name, analogous to <code><ahref="../reference/as.mo.html">as.mo()</a></code> and e.g.<code>mo_genus</code>.</p>
<li>New functions <code><ahref="../reference/mo_source.html">set_mo_source()</a></code> and <code><ahref="../reference/mo_source.html">get_mo_source()</a></code> to use your own predefined MO codes as input for <code><ahref="../reference/as.mo.html">as.mo()</a></code> and consequently all <code>mo_*</code> functions</li>
</li>
<li>Support for the upcoming <ahref="https://dplyr.tidyverse.org"><code>dplyr</code></a> version 0.8.0</li>
<li><p>New functions <code><ahref="../reference/mo_source.html">set_mo_source()</a></code> and <code><ahref="../reference/mo_source.html">get_mo_source()</a></code> to use your own predefined MO codes as input for <code><ahref="../reference/as.mo.html">as.mo()</a></code> and consequently all <code>mo_*</code> functions</p></li>
<li>New function <code><ahref="../reference/guess_ab_col.html">guess_ab_col()</a></code> to find an antibiotic column in a table</li>
<li><p>Support for the upcoming <ahref="https://dplyr.tidyverse.org"><code>dplyr</code></a> version 0.8.0</p></li>
<li>New function <code><ahref="../reference/as.mo.html">mo_failures()</a></code> to review values that could not be coerced to a valid MO code, using <code><ahref="../reference/as.mo.html">as.mo()</a></code>. This latter function will now only show a maximum of 10 uncoerced values and will refer to <code><ahref="../reference/as.mo.html">mo_failures()</a></code>.</li>
<li><p>New function <code><ahref="../reference/guess_ab_col.html">guess_ab_col()</a></code> to find an antibiotic column in a table</p></li>
<li>New function <code><ahref="../reference/as.mo.html">mo_uncertainties()</a></code> to review values that could be coerced to a valid MO code using <code><ahref="../reference/as.mo.html">as.mo()</a></code>, but with uncertainty.</li>
<li><p>New function <code><ahref="../reference/as.mo.html">mo_failures()</a></code> to review values that could not be coerced to a valid MO code, using <code><ahref="../reference/as.mo.html">as.mo()</a></code>. This latter function will now only show a maximum of 10 uncoerced values and will refer to <code><ahref="../reference/as.mo.html">mo_failures()</a></code>.</p></li>
<li>New function <code><ahref="../reference/as.mo.html">mo_renamed()</a></code> to get a list of all returned values from <code><ahref="../reference/as.mo.html">as.mo()</a></code> that have had taxonomic renaming</li>
<li><p>New function <code><ahref="../reference/as.mo.html">mo_uncertainties()</a></code> to review values that could be coerced to a valid MO code using <code><ahref="../reference/as.mo.html">as.mo()</a></code>, but with uncertainty.</p></li>
<li>New function <code><ahref="../reference/age.html">age()</a></code> to calculate the (patients) age in years</li>
<li><p>New function <code><ahref="../reference/as.mo.html">mo_renamed()</a></code> to get a list of all returned values from <code><ahref="../reference/as.mo.html">as.mo()</a></code> that have had taxonomic renaming</p></li>
<li>New function <code><ahref="../reference/age_groups.html">age_groups()</a></code> to split ages into custom or predefined groups (like children or elderly). This allows for easier demographic antimicrobial resistance analysis per age group.</li>
<li><p>New function <code><ahref="../reference/age.html">age()</a></code> to calculate the (patients) age in years</p></li>
<li><p>New function <code><ahref="../reference/age_groups.html">age_groups()</a></code> to split ages into custom or predefined groups (like children or elderly). This allows for easier demographic antimicrobial resistance analysis per age group.</p></li>
<li>
<li>
<p>New function <code><ahref="../reference/resistance_predict.html">ggplot_rsi_predict()</a></code> as well as the base R <code><ahref="https://rdrr.io/r/base/plot.html">plot()</a></code> function can now be used for resistance prediction calculated with <code><ahref="../reference/resistance_predict.html">resistance_predict()</a></code>:</p>
<p>New function <code><ahref="../reference/resistance_predict.html">ggplot_rsi_predict()</a></code> as well as the base R <code><ahref="https://rdrr.io/r/base/plot.html">plot()</a></code> function can now be used for resistance prediction calculated with <code><ahref="../reference/resistance_predict.html">resistance_predict()</a></code>:</p>
<li>New function <code><ahref="../reference/availability.html">availability()</a></code> to check the number of available (non-empty) results in a <code>data.frame</code>
<li><p>New function <code><ahref="../reference/availability.html">availability()</a></code> to check the number of available (non-empty) results in a <code>data.frame</code></p></li>
</li>
<li><p>New vignettes about how to conduct AMR analysis, predict antimicrobial resistance, use the <em>G</em>-test and more. These are also available (and even easier readable) on our website: <ahref="https://msberends.gitlab.io/AMR"class="uri">https://msberends.gitlab.io/AMR</a>.</p></li>
<li><p>New vignettes about how to conduct AMR analysis, predict antimicrobial resistance, use the <em>G</em>-test and more. These are also available (and even easier readable) on our website: <ahref="https://msberends.gitlab.io/AMR"class="uri">https://msberends.gitlab.io/AMR</a>.</p></li>
Using <code><ahref="../reference/as.mo.html">as.mo(..., allow_uncertain = 3)</a></code> could lead to very unreliable results.</li>
<p>Using <code><ahref="../reference/as.mo.html">as.mo(..., allow_uncertain = 3)</a></code> could lead to very unreliable results.</p>
<li>Implemented the latest publication of Becker <em>et al.</em> (2019), for categorising coagulase-negative <em>Staphylococci</em>
</li>
</li>
<li>All microbial IDs that found are now saved to a local file <code>~/.Rhistory_mo</code>. Use the new function <code>clean_mo_history()</code> to delete this file, which resets the algorithms.</li>
<li><p>Implemented the latest publication of Becker <em>et al.</em> (2019), for categorising coagulase-negative <em>Staphylococci</em></p></li>
<li><p>All microbial IDs that found are now saved to a local file <code>~/.Rhistory_mo</code>. Use the new function <code>clean_mo_history()</code> to delete this file, which resets the algorithms.</p></li>
<li>
<li>
<p>Incoercible results will now be considered ‘unknown’, MO code <code>UNKNOWN</code>. On foreign systems, properties of these will be translated to all languages already previously supported: German, Dutch, French, Italian, Spanish and Portuguese:</p>
<p>Incoercible results will now be considered ‘unknown’, MO code <code>UNKNOWN</code>. On foreign systems, properties of these will be translated to all languages already previously supported: German, Dutch, French, Italian, Spanish and Portuguese:</p>
<li>Header info is now available as a list, with the <code>header</code> function</li>
<li><p>Header info is now available as a list, with the <code>header</code> function</p></li>
<li>The parameter <code>header</code> is now set to <code>TRUE</code> at default, even for markdown</li>
<li><p>The parameter <code>header</code> is now set to <code>TRUE</code> at default, even for markdown</p></li>
<li>Added header info for class <code>mo</code> to show unique count of families, genera and species</li>
<li><p>Added header info for class <code>mo</code> to show unique count of families, genera and species</p></li>
<li>Now honours the <code>decimal.mark</code> setting, which just like <code>format</code> defaults to <code><ahref="https://rdrr.io/r/base/options.html">getOption("OutDec")</a></code>
<li><p>Now honours the <code>decimal.mark</code> setting, which just like <code>format</code> defaults to <code><ahref="https://rdrr.io/r/base/options.html">getOption("OutDec")</a></code></p></li>
</li>
<li><p>The new <code>big.mark</code> parameter will at default be <code>","</code> when <code>decimal.mark = "."</code> and <code>"."</code> otherwise</p></li>
<li>The new <code>big.mark</code> parameter will at default be <code>","</code> when <code>decimal.mark = "."</code> and <code>"."</code> otherwise</li>
<li><p>Fix for header text where all observations are <code>NA</code></p></li>
<li>Fix for header text where all observations are <code>NA</code>
<li><p>New parameter <code>droplevels</code> to exclude empty factor levels when input is a factor</p></li>
</li>
<li><p>Factor levels will be in header when present in input data (maximum of 5)</p></li>
<li>New parameter <code>droplevels</code> to exclude empty factor levels when input is a factor</li>
<li><p>Fix for using <code><ahref="https://dplyr.tidyverse.org/reference/select.html">select()</a></code> on frequency tables</p></li>
<li>Factor levels will be in header when present in input data (maximum of 5)</li>
<li>Fix for using <code><ahref="https://dplyr.tidyverse.org/reference/select.html">select()</a></code> on frequency tables</li>
</ul>
</ul>
</li>
</li>
<li>Function <code><ahref="../reference/ggplot_rsi.html">scale_y_percent()</a></code> now contains the <code>limits</code> parameter</li>
<li>Function <code><ahref="../reference/ggplot_rsi.html">scale_y_percent()</a></code> now contains the <code>limits</code> parameter</li>
@ -1108,9 +1129,9 @@ Using <code><a href="../reference/as.mo.html">as.mo(..., allow_uncertain = 3)</a
<li>Functions <code>MDRO</code>, <code>BRMO</code>, <code>MRGN</code> and <code>EUCAST_exceptional_phenotypes</code> were renamed to <code>mdro</code>, <code>brmo</code>, <code>mrgn</code> and <code>eucast_exceptional_phenotypes</code>
<li><p>Functions <code>MDRO</code>, <code>BRMO</code>, <code>MRGN</code> and <code>EUCAST_exceptional_phenotypes</code> were renamed to <code>mdro</code>, <code>brmo</code>, <code>mrgn</code> and <code>eucast_exceptional_phenotypes</code></p></li>
</li>
<li><p><code>EUCAST_rules</code> was renamed to <code>eucast_rules</code>, the old function still exists as a deprecated function</p></li>
<li>
<li>
<code>EUCAST_rules</code> was renamed to <code>eucast_rules</code>, the old function still exists as a deprecated function</li>
<p>Big changes to the <code>eucast_rules</code> function:</p>
<li>Big changes to the <code>eucast_rules</code> function:
<ul>
<ul>
<li>Now also applies rules from the EUCAST ‘Breakpoint tables for bacteria’, version 8.1, 2018, <ahref="http://www.eucast.org/clinical_breakpoints/"class="uri">http://www.eucast.org/clinical_breakpoints/</a> (see Source of the function)</li>
<li>Now also applies rules from the EUCAST ‘Breakpoint tables for bacteria’, version 8.1, 2018, <ahref="http://www.eucast.org/clinical_breakpoints/"class="uri">http://www.eucast.org/clinical_breakpoints/</a> (see Source of the function)</li>
<li>New parameter <code>rules</code> to specify which rules should be applied (expert rules, breakpoints, others or all)</li>
<li>New parameter <code>rules</code> to specify which rules should be applied (expert rules, breakpoints, others or all)</li>
@ -1146,10 +1166,9 @@ Using <code><a href="../reference/as.mo.html">as.mo(..., allow_uncertain = 3)</a
<li>Small fixes to EUCAST clinical breakpoint rules</li>
<li>Small fixes to EUCAST clinical breakpoint rules</li>
</ul>
</ul>
</li>
</li>
<li>Added column <code>kingdom</code> to the microorganisms data set, and function <code>mo_kingdom</code> to look up values</li>
<li><p>Added column <code>kingdom</code> to the microorganisms data set, and function <code>mo_kingdom</code> to look up values</p></li>
<li>Tremendous speed improvement for <code>as.mo</code> (and subsequently all <code>mo_*</code> functions), as empty values wil be ignored <em>a priori</em>
<li><p>Tremendous speed improvement for <code>as.mo</code> (and subsequently all <code>mo_*</code> functions), as empty values wil be ignored <em>a priori</em></p></li>
</li>
<li><p>Fewer than 3 characters as input for <code>as.mo</code> will return NA</p></li>
<li>Fewer than 3 characters as input for <code>as.mo</code> will return NA</li>
<li>
<li>
<p>Function <code>as.mo</code> (and all <code>mo_*</code> wrappers) now supports genus abbreviations with “species” attached</p>
<p>Function <code>as.mo</code> (and all <code>mo_*</code> wrappers) now supports genus abbreviations with “species” attached</p>
<li>Added parameter <code>combine_IR</code> (TRUE/FALSE) to functions <code>portion_df</code> and <code>count_df</code>, to indicate that all values of I and R must be merged into one, so the output only consists of S vs.IR (susceptible vs.non-susceptible)</li>
<li><p>Added parameter <code>combine_IR</code> (TRUE/FALSE) to functions <code>portion_df</code> and <code>count_df</code>, to indicate that all values of I and R must be merged into one, so the output only consists of S vs.IR (susceptible vs.non-susceptible)</p></li>
<li>Fix for <code>portion_*(..., as_percent = TRUE)</code> when minimal number of isolates would not be met</li>
<li><p>Fix for <code>portion_*(..., as_percent = TRUE)</code> when minimal number of isolates would not be met</p></li>
<li>Added parameter <code>also_single_tested</code> for <code>portion_*</code> and <code>count_*</code> functions to also include cases where not all antibiotics were tested but at least one of the tested antibiotics includes the target antimicribial interpretation, see <code><ahref="../reference/proportion.html">?portion</a></code>
<li><p>Added parameter <code>also_single_tested</code> for <code>portion_*</code> and <code>count_*</code> functions to also include cases where not all antibiotics were tested but at least one of the tested antibiotics includes the target antimicribial interpretation, see <code><ahref="../reference/proportion.html">?portion</a></code></p></li>
</li>
<li><p>Using <code>portion_*</code> functions now throws a warning when total available isolate is below parameter <code>minimum</code></p></li>
<li>Using <code>portion_*</code> functions now throws a warning when total available isolate is below parameter <code>minimum</code>
<li><p>Functions <code>as.mo</code>, <code>as.rsi</code>, <code>as.mic</code>, <code>as.atc</code> and <code>freq</code> will not set package name as attribute anymore</p></li>
</li>
<li>
<li>Functions <code>as.mo</code>, <code>as.rsi</code>, <code>as.mic</code>, <code>as.atc</code> and <code>freq</code> will not set package name as attribute anymore</li>
<p>Frequency tables - <code>freq()</code>:</p>
<li>Frequency tables - <code>freq()</code>:
<ul>
<ul>
<li>
<li>
<p>Support for grouping variables, test with:</p>
<p>Support for grouping variables, test with:</p>
@ -1178,29 +1196,25 @@ Using <code><a href="../reference/as.mo.html">as.mo(..., allow_uncertain = 3)</a
<spanclass="fu"><ahref="https://dplyr.tidyverse.org/reference/select.html">select</a></span>(-<spanclass="no">count</span>, -<spanclass="no">cum_count</span>) <spanclass="co"># only get item, percent, cum_percent</span></pre></div>
<spanclass="fu"><ahref="https://dplyr.tidyverse.org/reference/select.html">select</a></span>(-<spanclass="no">count</span>, -<spanclass="no">cum_count</span>) <spanclass="co"># only get item, percent, cum_percent</span></pre></div>
</li>
</li>
<li>Check for <code><ahref="https://hms.tidyverse.org/reference/Deprecated.html">hms::is.hms</a></code>
<li><p>Check for <code><ahref="https://hms.tidyverse.org/reference/Deprecated.html">hms::is.hms</a></code></p></li>
</li>
<li><p>Now prints in markdown at default in non-interactive sessions</p></li>
<li>Now prints in markdown at default in non-interactive sessions</li>
<li><p>No longer adds the factor level column and sorts factors on count again</p></li>
<li>No longer adds the factor level column and sorts factors on count again</li>
<li><p>Support for class <code>difftime</code></p></li>
<li>Support for class <code>difftime</code>
<li><p>New parameter <code>na</code>, to choose which character to print for empty values</p></li>
</li>
<li><p>New parameter <code>header</code> to turn the header info off (default when <code>markdown = TRUE</code>)</p></li>
<li>New parameter <code>na</code>, to choose which character to print for empty values</li>
<li><p>New parameter <code>title</code> to manually setbthe title of the frequency table</p></li>
<li>New parameter <code>header</code> to turn the header info off (default when <code>markdown = TRUE</code>)</li>
<li>New parameter <code>title</code> to manually setbthe title of the frequency table</li>
</ul>
</ul>
</li>
</li>
<li><p><code>first_isolate</code> now tries to find columns to use as input when parameters are left blank</p></li>
<li><p>Improvements for MDRO algorithm (function <code>mdro</code>)</p></li>
<li><p>Data set <code>septic_patients</code> is now a <code>data.frame</code>, not a tibble anymore</p></li>
<li><p>Removed diacritics from all authors (columns <code>microorganisms$ref</code> and <code>microorganisms.old$ref</code>) to comply with CRAN policy to only allow ASCII characters</p></li>
<li><p>Fix for <code>mo_property</code> not working properly</p></li>
<li><p>Fix for <code>eucast_rules</code> where some Streptococci would become ceftazidime R in EUCAST rule 4.5</p></li>
<li><p>Support for named vectors of class <code>mo</code>, useful for <code>top_freq()</code></p></li>
<li><p><code>ggplot_rsi</code> and <code>scale_y_percent</code> have <code>breaks</code> parameter</p></li>
<li>
<li>
<code>first_isolate</code> now tries to find columns to use as input when parameters are left blank</li>
<p>AI improvements for <code>as.mo</code>:</p>
<li>Improvements for MDRO algorithm (function <code>mdro</code>)</li>
<li>Data set <code>septic_patients</code> is now a <code>data.frame</code>, not a tibble anymore</li>
<li>Removed diacritics from all authors (columns <code>microorganisms$ref</code> and <code>microorganisms.old$ref</code>) to comply with CRAN policy to only allow ASCII characters</li>
<li>Fix for <code>mo_property</code> not working properly</li>
<li>Fix for <code>eucast_rules</code> where some Streptococci would become ceftazidime R in EUCAST rule 4.5</li>
<li>Support for named vectors of class <code>mo</code>, useful for <code>top_freq()</code>
</li>
<li>
<code>ggplot_rsi</code> and <code>scale_y_percent</code> have <code>breaks</code> parameter</li>
@ -1216,12 +1230,11 @@ Using <code><a href="../reference/as.mo.html">as.mo(..., allow_uncertain = 3)</a
</li>
</li>
</ul>
</ul>
</li>
</li>
<li>Fix for <code>join</code> functions</li>
<li><p>Fix for <code>join</code> functions</p></li>
<li>Speed improvement for <code>is.rsi.eligible</code>, now 15-20 times faster</li>
<li><p>Speed improvement for <code>is.rsi.eligible</code>, now 15-20 times faster</p></li>
<li>In <code>g.test</code>, when <code><ahref="https://rdrr.io/r/base/sum.html">sum(x)</a></code> is below 1000 or any of the expected values is below 5, Fisher’s Exact Test will be suggested</li>
<li><p>In <code>g.test</code>, when <code><ahref="https://rdrr.io/r/base/sum.html">sum(x)</a></code> is below 1000 or any of the expected values is below 5, Fisher’s Exact Test will be suggested</p></li>
<li>
<li><p><code>ab_name</code> will try to fall back on <code>as.atc</code> when no results are found</p></li>
<code>ab_name</code> will try to fall back on <code>as.atc</code> when no results are found</li>
<li><p>Removed the addin to view data sets</p></li>
<li>Removed the addin to view data sets</li>
<li><p>Percentages will now will rounded more logically (e.g.in <code>freq</code> function)</p></li>
<li><p>Percentages will now will rounded more logically (e.g.in <code>freq</code> function)</p></li>
</ul>
</ul>
</div>
</div>
@ -1235,16 +1248,17 @@ Using <code><a href="../reference/as.mo.html">as.mo(..., allow_uncertain = 3)</a
<li>The data set <code>microorganisms</code> now contains <strong>all microbial taxonomic data from ITIS</strong> (kingdoms Bacteria, Fungi and Protozoa), the Integrated Taxonomy Information System, available via <ahref="https://itis.gov"class="uri">https://itis.gov</a>. The data set now contains more than 18,000 microorganisms with all known bacteria, fungi and protozoa according ITIS with genus, species, subspecies, family, order, class, phylum and subkingdom. The new data set <code>microorganisms.old</code> contains all previously known taxonomic names from those kingdoms.</li>
<li><p>The data set <code>microorganisms</code> now contains <strong>all microbial taxonomic data from ITIS</strong> (kingdoms Bacteria, Fungi and Protozoa), the Integrated Taxonomy Information System, available via <ahref="https://itis.gov"class="uri">https://itis.gov</a>. The data set now contains more than 18,000 microorganisms with all known bacteria, fungi and protozoa according ITIS with genus, species, subspecies, family, order, class, phylum and subkingdom. The new data set <code>microorganisms.old</code> contains all previously known taxonomic names from those kingdoms.</p></li>
<li>New functions based on the existing function <code>mo_property</code>:
<li>
<p>New functions based on the existing function <code>mo_property</code>:</p>
<li>Functions <code>count_R</code>, <code>count_IR</code>, <code>count_I</code>, <code>count_SI</code> and <code>count_S</code> to selectively count resistant or susceptible isolates
<li>
<p>Functions <code>count_R</code>, <code>count_IR</code>, <code>count_I</code>, <code>count_SI</code> and <code>count_S</code> to selectively count resistant or susceptible isolates</p>
<ul>
<ul>
<li>Extra function <code>count_df</code> (which works like <code>portion_df</code>) to get all counts of S, I and R of a data set with antibiotic columns, with support for grouped variables</li>
<li>Extra function <code>count_df</code> (which works like <code>portion_df</code>) to get all counts of S, I and R of a data set with antibiotic columns, with support for grouped variables</li>
</ul>
</ul>
</li>
</li>
<li>Function <code>is.rsi.eligible</code> to check for columns that have valid antimicrobial results, but do not have the <code>rsi</code> class yet. Transform the columns of your raw data with: <code>data %>% mutate_if(is.rsi.eligible, as.rsi)</code>
<li><p>Function <code>is.rsi.eligible</code> to check for columns that have valid antimicrobial results, but do not have the <code>rsi</code> class yet. Transform the columns of your raw data with: <code>data %>% mutate_if(is.rsi.eligible, as.rsi)</code></p></li>
</li>
<li>
<li>
<p>Functions <code>as.mo</code> and <code>is.mo</code> as replacements for <code>as.bactid</code> and <code>is.bactid</code> (since the <code>microoganisms</code> data set not only contains bacteria). These last two functions are deprecated and will be removed in a future release. The <code>as.mo</code> function determines microbial IDs using intelligent rules:</p>
<p>Functions <code>as.mo</code> and <code>is.mo</code> as replacements for <code>as.bactid</code> and <code>is.bactid</code> (since the <code>microoganisms</code> data set not only contains bacteria). These last two functions are deprecated and will be removed in a future release. The <code>as.mo</code> function determines microbial IDs using intelligent rules:</p>
<li>Added parameter <code>reference_df</code> for <code>as.mo</code>, so users can supply their own microbial IDs, name or codes as a reference table</li>
<li><p>Added parameter <code>reference_df</code> for <code>as.mo</code>, so users can supply their own microbial IDs, name or codes as a reference table</p></li>
<li>Renamed all previous references to <code>bactid</code> to <code>mo</code>, like:
<li>
<p>Renamed all previous references to <code>bactid</code> to <code>mo</code>, like:</p>
<ul>
<ul>
<li>Column names inputs of <code>EUCAST_rules</code>, <code>first_isolate</code> and <code>key_antibiotics</code>
<li>Column names inputs of <code>EUCAST_rules</code>, <code>first_isolate</code> and <code>key_antibiotics</code>
</li>
</li>
@ -1301,20 +1316,19 @@ Using <code><a href="../reference/as.mo.html">as.mo(..., allow_uncertain = 3)</a
<li>All old syntaxes will still work with this version, but will throw warnings</li>
<li>All old syntaxes will still work with this version, but will throw warnings</li>
</ul>
</ul>
</li>
</li>
<li>Function <code>labels_rsi_count</code> to print datalabels on a RSI <code>ggplot2</code> model</li>
<li><p>Function <code>labels_rsi_count</code> to print datalabels on a RSI <code>ggplot2</code> model</p></li>
<li><p>Functions <code>as.atc</code> and <code>is.atc</code> to transform/look up antibiotic ATC codes as defined by the WHO. The existing function <code>guess_atc</code> is now an alias of <code>as.atc</code>.</p></li>
<li><p>Functions <code>as.atc</code> and <code>is.atc</code> to transform/look up antibiotic ATC codes as defined by the WHO. The existing function <code>guess_atc</code> is now an alias of <code>as.atc</code>.</p></li>
<li>Function <code>ab_property</code> and its aliases: <code>ab_name</code>, <code>ab_tradenames</code>, <code>ab_certe</code>, <code>ab_umcg</code> and <code>ab_trivial_nl</code>
<li><p>Function <code>ab_property</code> and its aliases: <code>ab_name</code>, <code>ab_tradenames</code>, <code>ab_certe</code>, <code>ab_umcg</code> and <code>ab_trivial_nl</code></p></li>
</li>
<li><p>Introduction to AMR as a vignette</p></li>
<li>Introduction to AMR as a vignette</li>
<li><p>Removed clipboard functions as it violated the CRAN policy</p></li>
<li>Removed clipboard functions as it violated the CRAN policy</li>
<li><p>Renamed <code>septic_patients$sex</code> to <code>septic_patients$gender</code></p></li>
<li><p>Renamed <code>septic_patients$sex</code> to <code>septic_patients$gender</code></p></li>
<li>Added three antimicrobial agents to the <code>antibiotics</code> data set: Terbinafine (D01BA02), Rifaximin (A07AA11) and Isoconazole (D01AC05)</li>
<li><p>Added three antimicrobial agents to the <code>antibiotics</code> data set: Terbinafine (D01BA02), Rifaximin (A07AA11) and Isoconazole (D01AC05)</p></li>
<li>
<li>
<p>Added 163 trade names to the <code>antibiotics</code> data set, it now contains 298 different trade names in total, e.g.:</p>
<p>Added 163 trade names to the <code>antibiotics</code> data set, it now contains 298 different trade names in total, e.g.:</p>
<li>For <code>first_isolate</code>, rows will be ignored when there’s no species available</li>
<li><p>For <code>first_isolate</code>, rows will be ignored when there’s no species available</p></li>
<li>Function <code>ratio</code> is now deprecated and will be removed in a future release, as it is not really the scope of this package</li>
<li><p>Function <code>ratio</code> is now deprecated and will be removed in a future release, as it is not really the scope of this package</p></li>
<li>Fix for <code>as.mic</code> for values ending in zeroes after a real number</li>
<li><p>Fix for <code>as.mic</code> for values ending in zeroes after a real number</p></li>
<li>Small fix where <em>B. fragilis</em> would not be found in the <code>microorganisms.umcg</code> data set</li>
<li><p>Small fix where <em>B. fragilis</em> would not be found in the <code>microorganisms.umcg</code> data set</p></li>
<li>Added <code>prevalence</code> column to the <code>microorganisms</code> data set</li>
<li><p>Added <code>prevalence</code> column to the <code>microorganisms</code> data set</p></li>
<li>Added parameters <code>minimum</code> and <code>as_percent</code> to <code>portion_df</code>
<li><p>Added parameters <code>minimum</code> and <code>as_percent</code> to <code>portion_df</code></p></li>
</li>
<li>
<li>
<p>Support for quasiquotation in the functions series <code>count_*</code> and <code>portions_*</code>, and <code>n_rsi</code>. This allows to check for more than 2 vectors or columns.</p>
<p>Support for quasiquotation in the functions series <code>count_*</code> and <code>portions_*</code>, and <code>n_rsi</code>. This allows to check for more than 2 vectors or columns.</p>
<li>Edited <code>ggplot_rsi</code> and <code>geom_rsi</code> so they can cope with <code>count_df</code>. The new <code>fun</code> parameter has value <code>portion_df</code> at default, but can be set to <code>count_df</code>.</li>
<li><p>Edited <code>ggplot_rsi</code> and <code>geom_rsi</code> so they can cope with <code>count_df</code>. The new <code>fun</code> parameter has value <code>portion_df</code> at default, but can be set to <code>count_df</code>.</p></li>
<li>Fix for <code>ggplot_rsi</code> when the <code>ggplot2</code> package was not loaded</li>
<li><p>Fix for <code>ggplot_rsi</code> when the <code>ggplot2</code> package was not loaded</p></li>
<li>Added datalabels function <code>labels_rsi_count</code> to <code>ggplot_rsi</code>
<li><p>Added datalabels function <code>labels_rsi_count</code> to <code>ggplot_rsi</code></p></li>
</li>
<li><p>Added possibility to set any parameter to <code>geom_rsi</code> (and <code>ggplot_rsi</code>) so you can set your own preferences</p></li>
<li>Added possibility to set any parameter to <code>geom_rsi</code> (and <code>ggplot_rsi</code>) so you can set your own preferences</li>
<li><p>Fix for joins, where predefined suffices would not be honoured</p></li>
<li>Fix for joins, where predefined suffices would not be honoured</li>
<li><p>Added parameter <code>quote</code> to the <code>freq</code> function</p></li>
<li>Added parameter <code>quote</code> to the <code>freq</code> function</li>
<li><p>Added generic function <code>diff</code> for frequency tables</p></li>
<li>Added generic function <code>diff</code> for frequency tables</li>
<li><p>Added longest en shortest character length in the frequency table (<code>freq</code>) header of class <code>character</code></p></li>
<li>Added longest en shortest character length in the frequency table (<code>freq</code>) header of class <code>character</code>
</li>
<li>
<li>
<p>Support for types (classes) list and matrix for <code>freq</code></p>
<p>Support for types (classes) list and matrix for <code>freq</code></p>
<li>Improvements for forecasting with <code>resistance_predict</code> and added more examples</li>
<li>Improvements for forecasting with <code>resistance_predict</code> and added more examples</li>
<li>More antibiotics added as parameters for EUCAST rules</li>
<li>More antibiotics added as parameters for EUCAST rules</li>
@ -1477,7 +1488,7 @@ Using <code><a href="../reference/as.mo.html">as.mo(..., allow_uncertain = 3)</a
</li>
</li>
</ul>
</ul>
</li>
</li>
<li>Now possible to coerce MIC values with a space between operator and value, i.e.<code><ahref="../reference/as.mic.html">as.mic("<= 0.002")</a></code> now works</li>
<li>Now possible to coerce MIC values with a space between operator and value, i.e.<code><ahref="../reference/as.mic.html">as.mic("<= 0.002")</a></code> now works</li>
<li>Classes <code>rsi</code> and <code>mic</code> do not add the attribute <code>package.version</code> anymore</li>
<li>Classes <code>rsi</code> and <code>mic</code> do not add the attribute <code>package.version</code> anymore</li>
<li>Added <code>"groups"</code> option for <code>atc_property(..., property)</code>. It will return a vector of the ATC hierarchy as defined by the <ahref="https://www.whocc.no/atc/structure_and_principles/">WHO</a>. The new function <code>atc_groups</code> is a convenient wrapper around this.</li>
<li>Added <code>"groups"</code> option for <code>atc_property(..., property)</code>. It will return a vector of the ATC hierarchy as defined by the <ahref="https://www.whocc.no/atc/structure_and_principles/">WHO</a>. The new function <code>atc_groups</code> is a convenient wrapper around this.</li>
<li>Build-in host check for <code>atc_property</code> as it requires the host set by <code>url</code> to be responsive</li>
<li>Build-in host check for <code>atc_property</code> as it requires the host set by <code>url</code> to be responsive</li>
@ -1507,9 +1518,9 @@ Using <code><a href="../reference/as.mo.html">as.mo(..., allow_uncertain = 3)</a
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