From 425f4ad8279660b786283f67b7699985e0da460b Mon Sep 17 00:00:00 2001 From: github-actions <41898282+github-actions[bot]@users.noreply.github.com> Date: Sat, 25 Apr 2026 14:29:32 +0000 Subject: [PATCH] Built site for AMR@3.0.1.9052: 3f1b20c --- 404.html | 2 +- CLAUDE.html | 4 +- LICENSE-text.html | 2 +- articles/AMR.html | 2 +- articles/AMR_for_Python.html | 2 +- articles/AMR_with_tidymodels.html | 2 +- articles/EUCAST.html | 2 +- articles/PCA.html | 2 +- articles/WHONET.html | 2 +- articles/WISCA.html | 2 +- articles/datasets.html | 2 +- articles/index.html | 2 +- authors.html | 2 +- index.html | 2 +- news/index.html | 18 ++++----- news/index.md | 28 ++++---------- pkgdown.yml | 2 +- reference/AMR-deprecated.html | 2 +- reference/AMR-options.html | 2 +- reference/AMR.html | 2 +- reference/WHOCC.html | 2 +- reference/WHONET.html | 2 +- reference/ab_from_text.html | 2 +- reference/ab_property.html | 2 +- reference/add_custom_antimicrobials.html | 2 +- reference/add_custom_microorganisms.html | 2 +- reference/age.html | 2 +- reference/age_groups.html | 2 +- reference/amr-tidymodels.html | 2 +- reference/amr_course.html | 2 +- reference/antibiogram.html | 2 +- reference/antimicrobial_selectors.html | 2 +- reference/antimicrobials.html | 2 +- reference/as.ab.html | 2 +- reference/as.av.html | 2 +- reference/as.disk.html | 2 +- reference/as.mic.html | 2 +- reference/as.mo.html | 2 +- reference/as.sir.html | 14 +++---- reference/as.sir.md | 49 ++++++++++++++++-------- reference/atc_online.html | 2 +- reference/av_from_text.html | 2 +- reference/av_property.html | 2 +- reference/availability.html | 2 +- reference/bug_drug_combinations.html | 2 +- reference/clinical_breakpoints.html | 2 +- reference/count.html | 2 +- reference/custom_eucast_rules.html | 2 +- reference/custom_mdro_guideline.html | 2 +- reference/dosage.html | 2 +- reference/esbl_isolates.html | 2 +- reference/example_isolates.html | 2 +- reference/example_isolates_unclean.html | 2 +- reference/export_ncbi_biosample.html | 2 +- reference/first_isolate.html | 2 +- reference/g.test.html | 2 +- reference/get_episode.html | 2 +- reference/ggplot_pca.html | 2 +- reference/ggplot_sir.html | 2 +- reference/guess_ab_col.html | 2 +- reference/index.html | 2 +- reference/interpretive_rules.html | 2 +- reference/intrinsic_resistant.html | 2 +- reference/italicise_taxonomy.html | 2 +- reference/join.html | 2 +- reference/key_antimicrobials.html | 2 +- reference/kurtosis.html | 2 +- reference/like.html | 2 +- reference/mdro.html | 2 +- reference/mean_amr_distance.html | 2 +- reference/microorganisms.codes.html | 2 +- reference/microorganisms.groups.html | 2 +- reference/microorganisms.html | 2 +- reference/mo_matching_score.html | 2 +- reference/mo_property.html | 2 +- reference/mo_source.html | 2 +- reference/pca.html | 2 +- reference/plot.html | 2 +- reference/proportion.html | 2 +- reference/random.html | 2 +- reference/resistance_predict.html | 2 +- reference/skewness.html | 2 +- reference/top_n_microorganisms.html | 2 +- reference/translate.html | 2 +- search.json | 2 +- 85 files changed, 140 insertions(+), 133 deletions(-) diff --git a/404.html b/404.html index e1ac27133..07d518e8c 100644 --- a/404.html +++ b/404.html @@ -31,7 +31,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/CLAUDE.html b/CLAUDE.html index 3ba5d84c0..555771133 100644 --- a/CLAUDE.html +++ b/CLAUDE.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 @@ -73,7 +73,7 @@ pkgdown::build_site() # Code coverage report -covr::package_coverage() +covr::package_coverage() From the shell: # CRAN check from parent directory R CMD check AMR diff --git a/LICENSE-text.html b/LICENSE-text.html index 829409693..f10a14420 100644 --- a/LICENSE-text.html +++ b/LICENSE-text.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/articles/AMR.html b/articles/AMR.html index 939c109bb..96aa10e2c 100644 --- a/articles/AMR.html +++ b/articles/AMR.html @@ -30,7 +30,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/articles/AMR_for_Python.html b/articles/AMR_for_Python.html index a86ad4387..3c5d232ef 100644 --- a/articles/AMR_for_Python.html +++ b/articles/AMR_for_Python.html @@ -30,7 +30,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/articles/AMR_with_tidymodels.html b/articles/AMR_with_tidymodels.html index e77c65bcd..5cc26df07 100644 --- a/articles/AMR_with_tidymodels.html +++ b/articles/AMR_with_tidymodels.html @@ -30,7 +30,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/articles/EUCAST.html b/articles/EUCAST.html index 8f0ae92cd..e28f1367c 100644 --- a/articles/EUCAST.html +++ b/articles/EUCAST.html @@ -30,7 +30,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/articles/PCA.html b/articles/PCA.html index caa008a77..1b04c4f19 100644 --- a/articles/PCA.html +++ b/articles/PCA.html @@ -30,7 +30,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/articles/WHONET.html b/articles/WHONET.html index 68f825631..f85809145 100644 --- a/articles/WHONET.html +++ b/articles/WHONET.html @@ -30,7 +30,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/articles/WISCA.html b/articles/WISCA.html index 172aa305e..ccb456907 100644 --- a/articles/WISCA.html +++ b/articles/WISCA.html @@ -30,7 +30,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/articles/datasets.html b/articles/datasets.html index c5cde755f..36708c44d 100644 --- a/articles/datasets.html +++ b/articles/datasets.html @@ -30,7 +30,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/articles/index.html b/articles/index.html index c4d450654..2a3723b23 100644 --- a/articles/index.html +++ b/articles/index.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/authors.html b/authors.html index 5d3502292..3876b1d33 100644 --- a/authors.html +++ b/authors.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/index.html b/index.html index 014a08c18..aa37266ac 100644 --- a/index.html +++ b/index.html @@ -33,7 +33,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/news/index.html b/news/index.html index 6a9804e35..91be66e82 100644 --- a/news/index.html +++ b/news/index.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 @@ -49,9 +49,9 @@ -AMR 3.0.1.9050 +AMR 3.0.1.9052 -New +New Support for clinical breakpoints of 2026 of both CLSI and EUCAST, by adding all of their over 5,700 new clinical breakpoints to the clinical_breakpoints data set for usage in as.sir(). EUCAST 2026 is now the new default guideline for all MIC and disk diffusion interpretations. Integration with the tidymodels framework to allow seamless use of SIR, MIC and disk data in modelling pipelines via recipes @@ -86,10 +86,8 @@ Two new NA objects, NA_ab_ and NA_mo_, analogous to base R’s NA_character_ and NA_integer_, for use in pipelines that require typed missing values -Fixes - -as.sir() with reference_data: custom guideline names now correctly classify values as R using EUCAST convention (> breakpoint_R for MIC, < breakpoint_R for disk); custom breakpoints with host = NA now serve as a host-agnostic fallback when no host-specific row matches (fixes #239) -Fixed multiple bugs in the parallel = TRUE mode of as.sir() for data frames: (1) PSOCK workers (Windows / R < 4.0) now correctly load the AMR package before processing, with a graceful fallback to sequential mode when the package cannot be loaded; (2) resolved stale-environment issue where the PSOCK path read a frozen copy of AMR_env instead of the live one, causing the wrong log entries to be captured; (3) fixed log-entry duplication in the fork-based path (mclapply) where pre-existing sir_interpretation_history rows were included in every worker’s captured log; (4) removed use of non-exported internal functions (%pm>%, pm_pull, as.sir.default) from the worker closure, which made PSOCK workers fail; (5) suppressed per-column progress messages inside workers to prevent interleaved console output; (6) fixed a malformed Unicode escape \u00a (3 digits) in the “DONE” status message +Fixes +Fixed multiple bugs in the parallel = TRUE mode of as.sir() for data frames Fixed a bug in as.sir() where values that were purely numeric (e.g., "1") and matched the broad SIR-matching regex would be incorrectly stripped of all content by the Unicode letter filter Fixed a bug in as.mic() where MIC values in scientific notation (e.g., "1e-3") were incorrectly handled because the letter e was removed along with other Unicode letters; scientific notation e is now preserved Fixed a bug in as.ab() where certain AB codes containing “PH” or “TH” (such as ETH, MTH, PHE, PHN, STH, THA, THI1) would incorrectly return NA when combined in a vector with any untranslatable value (#245) @@ -111,8 +109,10 @@ -Updates -Extensive cli integration for better message handling and clickable links in messages and warnings (#191, #265) +Updates + +as.sir() with reference_data: custom guideline names now correctly classify values as R using EUCAST convention (> breakpoint_R for MIC, < breakpoint_R for disk); custom breakpoints with host = NA now serve as a host-agnostic fallback when no host-specific row matches (#239) +Extensive cli integration for better message handling and clickable links in messages and warnings (#191, #265) mdro() now infers resistance for a missing base drug column from an available corresponding drug+inhibitor combination showing resistance (e.g., piperacillin is absent but required, while piperacillin/tazobactam available and resistant). Can be set with the new argument infer_from_combinations, which defaults to TRUE (#209). Note that this can yield a higher MDRO detection (which is a good thing as it has become more reliable). diff --git a/news/index.md b/news/index.md index 2fe3d2b45..efab6a365 100644 --- a/news/index.md +++ b/news/index.md @@ -1,6 +1,6 @@ # Changelog -## AMR 3.0.1.9050 +## AMR 3.0.1.9052 #### New @@ -63,27 +63,9 @@ #### Fixes -- [`as.sir()`](https://amr-for-r.org/reference/as.sir.md) with - `reference_data`: custom guideline names now correctly classify values - as R using EUCAST convention (`> breakpoint_R` for MIC, - `< breakpoint_R` for disk); custom breakpoints with `host = NA` now - serve as a host-agnostic fallback when no host-specific row matches - (fixes [\#239](https://github.com/msberends/AMR/issues/239)) - Fixed multiple bugs in the `parallel = TRUE` mode of [`as.sir()`](https://amr-for-r.org/reference/as.sir.md) for data - frames: (1) PSOCK workers (Windows / R \< 4.0) now correctly load the - AMR package before processing, with a graceful fallback to sequential - mode when the package cannot be loaded; (2) resolved stale-environment - issue where the PSOCK path read a frozen copy of `AMR_env` instead of - the live one, causing the wrong log entries to be captured; (3) fixed - log-entry duplication in the fork-based path (`mclapply`) where - pre-existing `sir_interpretation_history` rows were included in every - worker’s captured log; (4) removed use of non-exported internal - functions (`%pm>%`, `pm_pull`, `as.sir.default`) from the worker - closure, which made PSOCK workers fail; (5) suppressed per-column - progress messages inside workers to prevent interleaved console - output; (6) fixed a malformed Unicode escape `\u00a` (3 digits) in the - “DONE” status message + frames - Fixed a bug in [`as.sir()`](https://amr-for-r.org/reference/as.sir.md) where values that were purely numeric (e.g., `"1"`) and matched the broad SIR-matching regex would be incorrectly stripped of all content @@ -145,6 +127,12 @@ #### Updates +- [`as.sir()`](https://amr-for-r.org/reference/as.sir.md) with + `reference_data`: custom guideline names now correctly classify values + as R using EUCAST convention (`> breakpoint_R` for MIC, + `< breakpoint_R` for disk); custom breakpoints with `host = NA` now + serve as a host-agnostic fallback when no host-specific row matches + ([\#239](https://github.com/msberends/AMR/issues/239)) - Extensive `cli` integration for better message handling and clickable links in messages and warnings ([\#191](https://github.com/msberends/AMR/issues/191), diff --git a/pkgdown.yml b/pkgdown.yml index 18c32d330..54d942efe 100644 --- a/pkgdown.yml +++ b/pkgdown.yml @@ -10,7 +10,7 @@ articles: PCA: PCA.html WHONET: WHONET.html WISCA: WISCA.html -last_built: 2026-04-25T12:44Z +last_built: 2026-04-25T14:24Z urls: reference: https://amr-for-r.org/reference article: https://amr-for-r.org/articles diff --git a/reference/AMR-deprecated.html b/reference/AMR-deprecated.html index 3832bb14c..91a4e50a2 100644 --- a/reference/AMR-deprecated.html +++ b/reference/AMR-deprecated.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/AMR-options.html b/reference/AMR-options.html index 5f3089665..d1412ba3c 100644 --- a/reference/AMR-options.html +++ b/reference/AMR-options.html @@ -9,7 +9,7 @@ options(AMR_guideline = "CLSI")'>AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/AMR.html b/reference/AMR.html index 8fec087ba..37c766f6b 100644 --- a/reference/AMR.html +++ b/reference/AMR.html @@ -21,7 +21,7 @@ The AMR package is available in English, Arabic, Bengali, Chinese, Czech, Danish AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/WHOCC.html b/reference/WHOCC.html index f0fb1034c..241063696 100644 --- a/reference/WHOCC.html +++ b/reference/WHOCC.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/WHONET.html b/reference/WHONET.html index 198a5fe64..4e62b17d3 100644 --- a/reference/WHONET.html +++ b/reference/WHONET.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/ab_from_text.html b/reference/ab_from_text.html index 5495127e7..6b3499ef7 100644 --- a/reference/ab_from_text.html +++ b/reference/ab_from_text.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/ab_property.html b/reference/ab_property.html index 137bd5f35..ad3d3bc65 100644 --- a/reference/ab_property.html +++ b/reference/ab_property.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/add_custom_antimicrobials.html b/reference/add_custom_antimicrobials.html index 4f30f2871..f7d652ade 100644 --- a/reference/add_custom_antimicrobials.html +++ b/reference/add_custom_antimicrobials.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/add_custom_microorganisms.html b/reference/add_custom_microorganisms.html index 0adc74ef8..c33de5249 100644 --- a/reference/add_custom_microorganisms.html +++ b/reference/add_custom_microorganisms.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/age.html b/reference/age.html index ff97bd5db..9afeee631 100644 --- a/reference/age.html +++ b/reference/age.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/age_groups.html b/reference/age_groups.html index d942babf8..0dbf2e364 100644 --- a/reference/age_groups.html +++ b/reference/age_groups.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/amr-tidymodels.html b/reference/amr-tidymodels.html index 916e01e91..63ba5df2f 100644 --- a/reference/amr-tidymodels.html +++ b/reference/amr-tidymodels.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/amr_course.html b/reference/amr_course.html index 00762900e..fe8c319f7 100644 --- a/reference/amr_course.html +++ b/reference/amr_course.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/antibiogram.html b/reference/antibiogram.html index ed03962d9..7171a0051 100644 --- a/reference/antibiogram.html +++ b/reference/antibiogram.html @@ -9,7 +9,7 @@ Adhering to previously described approaches (see Source) and especially the Baye AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/antimicrobial_selectors.html b/reference/antimicrobial_selectors.html index 579483d0c..29cf65ffa 100644 --- a/reference/antimicrobial_selectors.html +++ b/reference/antimicrobial_selectors.html @@ -17,7 +17,7 @@ my_data_with_all_these_columns %>% AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/antimicrobials.html b/reference/antimicrobials.html index c713ed22e..5bd2226bd 100644 --- a/reference/antimicrobials.html +++ b/reference/antimicrobials.html @@ -9,7 +9,7 @@ The antibiotics data set has been renamed to antimicrobials. The old name will b AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/as.ab.html b/reference/as.ab.html index d495dde21..1fa6a9cda 100644 --- a/reference/as.ab.html +++ b/reference/as.ab.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/as.av.html b/reference/as.av.html index 0d55ca101..947f3a1b8 100644 --- a/reference/as.av.html +++ b/reference/as.av.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/as.disk.html b/reference/as.disk.html index 680fd3fb4..9fe98a286 100644 --- a/reference/as.disk.html +++ b/reference/as.disk.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/as.mic.html b/reference/as.mic.html index 7d4c14a0a..15b14f2f9 100644 --- a/reference/as.mic.html +++ b/reference/as.mic.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/as.mo.html b/reference/as.mo.html index 7236f6827..d43431292 100644 --- a/reference/as.mo.html +++ b/reference/as.mo.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/as.sir.html b/reference/as.sir.html index cd5e1c2b6..043167bd7 100644 --- a/reference/as.sir.html +++ b/reference/as.sir.html @@ -9,7 +9,7 @@ Breakpoints are currently implemented from EUCAST 2011-2026 and CLSI 2011-2026, AMR (for R) - 3.0.1.9050 + 3.0.1.9052 @@ -187,7 +187,7 @@ Breakpoints are currently implemented from EUCAST 2011-2026 and CLSI 2011-2026, reference_data -A data.frame to be used for interpretation, which defaults to the clinical_breakpoints data set. Changing this argument allows for using own interpretation guidelines. This argument must contain a data set that is equal in structure to the clinical_breakpoints data set (same column names and column types). Please note that the guideline argument will be ignored when reference_data is manually set. +A data.frame to be used for interpretation, which defaults to the clinical_breakpoints data set. Changing this argument allows for using own interpretation guidelines. This argument must have the same column names as the clinical_breakpoints data set. Column types are coerced automatically where possible: the mo column is passed through as.mo(), the ab column through as.ab(), and plain character, numeric, or logical columns are cast to the expected type. When reference_data is manually set, the guideline argument is optional: if omitted (or if its value does not match any row in the custom data), all rows in reference_data are considered. If guideline is set to a value that exists in the guideline column of the custom data, only matching rows are used — useful when a single custom table contains multiple guidelines. For the R classification, the EUCAST convention is used by default: MIC values > breakpoint_R and disk diffusion values < breakpoint_R are classified as R, with values between breakpoint_S and breakpoint_R classified as I (or SDD). Only when using the standard clinical_breakpoints with a CLSI guideline are the closed-interval rules (>= breakpoint_R for MIC, <= breakpoint_R for disk) applied; custom reference_data always uses the open-interval (EUCAST) convention regardless of the guideline name. substitute_missing_r_breakpoint @@ -227,7 +227,7 @@ Breakpoints are currently implemented from EUCAST 2011-2026 and CLSI 2011-2026, parallel -A logical to indicate if parallel computing must be used, defaults to FALSE. This requires no additional packages, as the used parallel package is part of base R. On Windows and on R < 4.0.0 parallel::parLapply() will be used, in all other cases the more efficient parallel::mclapply() will be used. +A logical to indicate if parallel computing must be used, defaults to FALSE. The parallel package is part of base R and no additional packages are required. On Unix/macOS with R >= 4.0.0, parallel::mclapply() (fork-based) is used; on Windows and R < 4.0.0, parallel::parLapply() with a PSOCK cluster is used (requires the AMR package to be installed, not just loaded via devtools::load_all()). Parallelism distributes columns across cores; it is most beneficial when there are many antibiotic columns and a large number of rows. max_cores @@ -424,10 +424,10 @@ Breakpoints are currently implemented from EUCAST 2011-2026 and CLSI 2011-2026, #> # A tibble: 4 × 18 #> datetime index method ab_given mo_given host_given input_given #> <dttm> <int> <chr> <chr> <chr> <chr> <chr> -#> 1 2026-04-25 12:45:43 1 MIC amoxicillin Escherich… human 8 -#> 2 2026-04-25 12:45:43 1 MIC cipro Escherich… human 0.256 -#> 3 2026-04-25 12:45:44 1 DISK tobra Escherich… human 16 -#> 4 2026-04-25 12:45:44 1 DISK genta Escherich… human 18 +#> 1 2026-04-25 14:25:30 1 MIC amoxicillin Escherich… human 8 +#> 2 2026-04-25 14:25:30 1 MIC cipro Escherich… human 0.256 +#> 3 2026-04-25 14:25:31 1 DISK tobra Escherich… human 16 +#> 4 2026-04-25 14:25:31 1 DISK genta Escherich… human 18 #> # ℹ 11 more variables: ab <ab>, mo <mo>, host <chr>, input <chr>, #> # outcome <sir>, notes <chr>, guideline <chr>, ref_table <chr>, uti <lgl>, #> # breakpoint_S_R <chr>, site <chr> diff --git a/reference/as.sir.md b/reference/as.sir.md index 07ff42908..2a29ac84b 100644 --- a/reference/as.sir.md +++ b/reference/as.sir.md @@ -247,12 +247,28 @@ disk diffusion diameters: interpretation, which defaults to the [clinical_breakpoints](https://amr-for-r.org/reference/clinical_breakpoints.md) data set. Changing this argument allows for using own interpretation - guidelines. This argument must contain a data set that is equal in - structure to the + guidelines. This argument must have the same column names as the [clinical_breakpoints](https://amr-for-r.org/reference/clinical_breakpoints.md) - data set (same column names and column types). Please note that the - `guideline` argument will be ignored when `reference_data` is manually - set. + data set. Column types are coerced automatically where possible: the + `mo` column is passed through + [`as.mo()`](https://amr-for-r.org/reference/as.mo.md), the `ab` column + through [`as.ab()`](https://amr-for-r.org/reference/as.ab.md), and + plain character, numeric, or logical columns are cast to the expected + type. When `reference_data` is manually set, the `guideline` argument + is optional: if omitted (or if its value does not match any row in the + custom data), all rows in `reference_data` are considered. If + `guideline` is set to a value that exists in the `guideline` column of + the custom data, only matching rows are used — useful when a single + custom table contains multiple guidelines. For the R classification, + the EUCAST convention is used by default: MIC values `> breakpoint_R` + and disk diffusion values `< breakpoint_R` are classified as R, with + values between `breakpoint_S` and `breakpoint_R` classified as I (or + SDD). Only when using the standard + [clinical_breakpoints](https://amr-for-r.org/reference/clinical_breakpoints.md) + with a CLSI guideline are the closed-interval rules (`>= breakpoint_R` + for MIC, `<= breakpoint_R` for disk) applied; custom `reference_data` + always uses the open-interval (EUCAST) convention regardless of the + guideline name. - substitute_missing_r_breakpoint: @@ -332,13 +348,16 @@ disk diffusion diameters: - parallel: A [logical](https://rdrr.io/r/base/logical.html) to indicate if - parallel computing must be used, defaults to `FALSE`. This requires no - additional packages, as the used `parallel` package is part of base R. - On Windows and on R \< 4.0.0 - [`parallel::parLapply()`](https://rdrr.io/r/parallel/clusterApply.html) - will be used, in all other cases the more efficient + parallel computing must be used, defaults to `FALSE`. The `parallel` + package is part of base R and no additional packages are required. On + Unix/macOS with R \>= 4.0.0, [`parallel::mclapply()`](https://rdrr.io/r/parallel/mclapply.html) - will be used. + (fork-based) is used; on Windows and R \< 4.0.0, + [`parallel::parLapply()`](https://rdrr.io/r/parallel/clusterApply.html) + with a PSOCK cluster is used (requires the AMR package to be + installed, not just loaded via `devtools::load_all()`). Parallelism + distributes columns across cores; it is most beneficial when there are + many antibiotic columns and a large number of rows. - max_cores: @@ -660,10 +679,10 @@ sir_interpretation_history() #> # A tibble: 4 × 18 #> datetime index method ab_given mo_given host_given input_given #> -#> 1 2026-04-25 12:45:43 1 MIC amoxicillin Escherich… human 8 -#> 2 2026-04-25 12:45:43 1 MIC cipro Escherich… human 0.256 -#> 3 2026-04-25 12:45:44 1 DISK tobra Escherich… human 16 -#> 4 2026-04-25 12:45:44 1 DISK genta Escherich… human 18 +#> 1 2026-04-25 14:25:30 1 MIC amoxicillin Escherich… human 8 +#> 2 2026-04-25 14:25:30 1 MIC cipro Escherich… human 0.256 +#> 3 2026-04-25 14:25:31 1 DISK tobra Escherich… human 16 +#> 4 2026-04-25 14:25:31 1 DISK genta Escherich… human 18 #> # ℹ 11 more variables: ab , mo , host , input , #> # outcome , notes , guideline , ref_table , uti , #> # breakpoint_S_R , site diff --git a/reference/atc_online.html b/reference/atc_online.html index 45eb9c33a..598979fdc 100644 --- a/reference/atc_online.html +++ b/reference/atc_online.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/av_from_text.html b/reference/av_from_text.html index 40ce6b431..c32b17f0b 100644 --- a/reference/av_from_text.html +++ b/reference/av_from_text.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/av_property.html b/reference/av_property.html index 07fede8fe..b1099ddaf 100644 --- a/reference/av_property.html +++ b/reference/av_property.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/availability.html b/reference/availability.html index de344e69c..ba0100d08 100644 --- a/reference/availability.html +++ b/reference/availability.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/bug_drug_combinations.html b/reference/bug_drug_combinations.html index 616ccb2aa..197ae1973 100644 --- a/reference/bug_drug_combinations.html +++ b/reference/bug_drug_combinations.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/clinical_breakpoints.html b/reference/clinical_breakpoints.html index 47f45eebe..a0d20f98b 100644 --- a/reference/clinical_breakpoints.html +++ b/reference/clinical_breakpoints.html @@ -21,7 +21,7 @@ Use as.sir() to transform MICs or disks measurements to SIR values.">AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/count.html b/reference/count.html index 49bddda0f..8cf092f15 100644 --- a/reference/count.html +++ b/reference/count.html @@ -9,7 +9,7 @@ count_resistant() should be used to count resistant isolates, count_susceptible( AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/custom_eucast_rules.html b/reference/custom_eucast_rules.html index 9c2dc731a..1b3ebea77 100644 --- a/reference/custom_eucast_rules.html +++ b/reference/custom_eucast_rules.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/custom_mdro_guideline.html b/reference/custom_mdro_guideline.html index 182985079..cd74e6ed6 100644 --- a/reference/custom_mdro_guideline.html +++ b/reference/custom_mdro_guideline.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/dosage.html b/reference/dosage.html index 206147724..446108645 100644 --- a/reference/dosage.html +++ b/reference/dosage.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/esbl_isolates.html b/reference/esbl_isolates.html index 4cbaebfdf..764c3524b 100644 --- a/reference/esbl_isolates.html +++ b/reference/esbl_isolates.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/example_isolates.html b/reference/example_isolates.html index 66aba2182..2ba5cf591 100644 --- a/reference/example_isolates.html +++ b/reference/example_isolates.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/example_isolates_unclean.html b/reference/example_isolates_unclean.html index a3ec7ba5c..af95754c6 100644 --- a/reference/example_isolates_unclean.html +++ b/reference/example_isolates_unclean.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/export_ncbi_biosample.html b/reference/export_ncbi_biosample.html index fe5ad712c..acd5f1468 100644 --- a/reference/export_ncbi_biosample.html +++ b/reference/export_ncbi_biosample.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/first_isolate.html b/reference/first_isolate.html index fffa876a7..a23960e6c 100644 --- a/reference/first_isolate.html +++ b/reference/first_isolate.html @@ -9,7 +9,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/g.test.html b/reference/g.test.html index 1991c93b7..3c24d5e66 100644 --- a/reference/g.test.html +++ b/reference/g.test.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/get_episode.html b/reference/get_episode.html index d628ed328..ec2997f40 100644 --- a/reference/get_episode.html +++ b/reference/get_episode.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/ggplot_pca.html b/reference/ggplot_pca.html index 54a199772..d91db97ac 100644 --- a/reference/ggplot_pca.html +++ b/reference/ggplot_pca.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/ggplot_sir.html b/reference/ggplot_sir.html index 97a3ffd6f..6b69c9560 100644 --- a/reference/ggplot_sir.html +++ b/reference/ggplot_sir.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/guess_ab_col.html b/reference/guess_ab_col.html index cd1c75d55..461571631 100644 --- a/reference/guess_ab_col.html +++ b/reference/guess_ab_col.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/index.html b/reference/index.html index 089b8820f..e681d97c8 100644 --- a/reference/index.html +++ b/reference/index.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/interpretive_rules.html b/reference/interpretive_rules.html index 7e329a4c6..26258134e 100644 --- a/reference/interpretive_rules.html +++ b/reference/interpretive_rules.html @@ -9,7 +9,7 @@ To improve the interpretation of the antibiogram before CLSI/EUCAST interpretive AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/intrinsic_resistant.html b/reference/intrinsic_resistant.html index df7f23120..e52c55a5c 100644 --- a/reference/intrinsic_resistant.html +++ b/reference/intrinsic_resistant.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/italicise_taxonomy.html b/reference/italicise_taxonomy.html index c4736ee00..b02e175c5 100644 --- a/reference/italicise_taxonomy.html +++ b/reference/italicise_taxonomy.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/join.html b/reference/join.html index 192684f1d..fb640b5b3 100644 --- a/reference/join.html +++ b/reference/join.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/key_antimicrobials.html b/reference/key_antimicrobials.html index d56982f82..dff10f94d 100644 --- a/reference/key_antimicrobials.html +++ b/reference/key_antimicrobials.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/kurtosis.html b/reference/kurtosis.html index ab041aa5f..2052cff35 100644 --- a/reference/kurtosis.html +++ b/reference/kurtosis.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/like.html b/reference/like.html index 70e264f22..ef81fa9d9 100644 --- a/reference/like.html +++ b/reference/like.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/mdro.html b/reference/mdro.html index 834bf2742..ff507325d 100644 --- a/reference/mdro.html +++ b/reference/mdro.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/mean_amr_distance.html b/reference/mean_amr_distance.html index 79b702d68..ad50ee1a7 100644 --- a/reference/mean_amr_distance.html +++ b/reference/mean_amr_distance.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/microorganisms.codes.html b/reference/microorganisms.codes.html index 0e1c84c48..f00af79be 100644 --- a/reference/microorganisms.codes.html +++ b/reference/microorganisms.codes.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/microorganisms.groups.html b/reference/microorganisms.groups.html index 52c6c7496..072d7716c 100644 --- a/reference/microorganisms.groups.html +++ b/reference/microorganisms.groups.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/microorganisms.html b/reference/microorganisms.html index b067c9900..c69bcf3e9 100644 --- a/reference/microorganisms.html +++ b/reference/microorganisms.html @@ -9,7 +9,7 @@ This data set is carefully crafted, yet made 100% reproducible from public and a AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/mo_matching_score.html b/reference/mo_matching_score.html index d6045bc7a..e42873f79 100644 --- a/reference/mo_matching_score.html +++ b/reference/mo_matching_score.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/mo_property.html b/reference/mo_property.html index da97a4fc6..6d6f37b3e 100644 --- a/reference/mo_property.html +++ b/reference/mo_property.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/mo_source.html b/reference/mo_source.html index d403eb7ff..2a1b7f52d 100644 --- a/reference/mo_source.html +++ b/reference/mo_source.html @@ -9,7 +9,7 @@ This is the fastest way to have your organisation (or analysis) specific codes p AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/pca.html b/reference/pca.html index d33f66274..0952d5a5d 100644 --- a/reference/pca.html +++ b/reference/pca.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/plot.html b/reference/plot.html index b68817654..ab53150c0 100644 --- a/reference/plot.html +++ b/reference/plot.html @@ -9,7 +9,7 @@ Especially the scale_*_mic() functions are relevant wrappers to plot MIC values AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/proportion.html b/reference/proportion.html index 47f7f8ff0..416ffc374 100644 --- a/reference/proportion.html +++ b/reference/proportion.html @@ -9,7 +9,7 @@ resistance() should be used to calculate resistance, susceptibility() should be AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/random.html b/reference/random.html index 8d17e09d0..dc9d987ac 100644 --- a/reference/random.html +++ b/reference/random.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/resistance_predict.html b/reference/resistance_predict.html index 03183bece..987541170 100644 --- a/reference/resistance_predict.html +++ b/reference/resistance_predict.html @@ -9,7 +9,7 @@ NOTE: These functions are deprecated and will be removed in a future version. Us AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/skewness.html b/reference/skewness.html index cf9efc36a..8d4013825 100644 --- a/reference/skewness.html +++ b/reference/skewness.html @@ -9,7 +9,7 @@ When negative ('left-skewed'): the left tail is longer; the mass of the distribu AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/top_n_microorganisms.html b/reference/top_n_microorganisms.html index e1a9189a5..18106be15 100644 --- a/reference/top_n_microorganisms.html +++ b/reference/top_n_microorganisms.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/reference/translate.html b/reference/translate.html index 4a83b0ce3..239d30f6f 100644 --- a/reference/translate.html +++ b/reference/translate.html @@ -7,7 +7,7 @@ AMR (for R) - 3.0.1.9050 + 3.0.1.9052 diff --git a/search.json b/search.json index 4c929d778..95260c0de 100644 --- a/search.json +++ b/search.json @@ -1 +1 @@ -[{"path":"https://amr-for-r.org/CLAUDE.html","id":null,"dir":"","previous_headings":"","what":"CLAUDE.md — AMR R Package","title":"CLAUDE.md — AMR R Package","text":"file provides context Claude Code working repository.","code":""},{"path":"https://amr-for-r.org/CLAUDE.html","id":"project-overview","dir":"","previous_headings":"","what":"Project Overview","title":"CLAUDE.md — AMR R Package","text":"AMR zero-dependency R package antimicrobial resistance (AMR) data analysis using One Health approach. peer-reviewed, used 175+ countries, supports 28 languages. Key capabilities: - SIR (Susceptible/Intermediate/Resistant) classification using EUCAST 2011–2025 CLSI 2011–2025 breakpoints - Antibiogram generation: traditional, combined, syndromic, WISCA - Microorganism taxonomy database (~79,000 species) - Antimicrobial drug database (~620 drugs) - Multi-drug resistant organism (MDRO) classification - First-isolate identification - Minimum Inhibitory Concentration (MIC) disk diffusion handling - Multilingual output (28 languages)","code":""},{"path":"https://amr-for-r.org/CLAUDE.html","id":"common-commands","dir":"","previous_headings":"","what":"Common Commands","title":"CLAUDE.md — AMR R Package","text":"commands run inside R session: shell:","code":"# Rebuild documentation (roxygen2 → .Rd files + NAMESPACE) devtools::document() # Run all tests devtools::test() # Full package check (CRAN-level: docs + tests + checks) devtools::check() # Build pkgdown website locally pkgdown::build_site() # Code coverage report covr::package_coverage() # CRAN check from parent directory R CMD check AMR"},{"path":"https://amr-for-r.org/CLAUDE.html","id":"repository-structure","dir":"","previous_headings":"","what":"Repository Structure","title":"CLAUDE.md — AMR R Package","text":"","code":"R/ # All R source files (62 files, ~28,000 lines) man/ # Auto-generated .Rd documentation (do not edit manually) tests/testthat/ # testthat test files (test-*.R) and helper-functions.R data/ # Pre-compiled .rda datasets data-raw/ # Scripts used to generate data/ files vignettes/ # Rmd vignette articles inst/ # Installed files (translations, etc.) _pkgdown.yml # pkgdown website configuration"},{"path":"https://amr-for-r.org/CLAUDE.html","id":"r-source-file-conventions","dir":"","previous_headings":"","what":"R Source File Conventions","title":"CLAUDE.md — AMR R Package","text":"Naming conventions R/: Key source files: aa_helper_functions.R / aa_helper_pm_functions.R — internal utility functions (large; ~63 KB ~37 KB) aa_globals.R — global constants breakpoint lookup structures aa_options.R — amr_options() / get_AMR_option() system mo.R / mo_property.R — microorganism lookup properties ab.R / ab_property.R — antimicrobial drug functions av.R / av_property.R — antiviral drug functions sir.R / sir_calc.R / sir_df.R — SIR classification engine mic.R / disk.R — MIC disk diffusion classes antibiogram.R — antibiogram generation (traditional, combined, syndromic, WISCA) first_isolate.R — first-isolate identification algorithms mdro.R — MDRO classification (EUCAST, CLSI, CDC, custom guidelines) amr_selectors.R — tidyselect helpers selecting AMR columns interpretive_rules.R / custom_eucast_rules.R — clinical interpretation rules translate.R — 28-language translation system ggplot_sir.R / ggplot_pca.R / plotting.R — visualisation functions","code":""},{"path":"https://amr-for-r.org/CLAUDE.html","id":"custom-s3-classes","dir":"","previous_headings":"","what":"Custom S3 Classes","title":"CLAUDE.md — AMR R Package","text":"package defines five S3 classes full print/format/plot/vctrs support:","code":""},{"path":"https://amr-for-r.org/CLAUDE.html","id":"data-files","dir":"","previous_headings":"","what":"Data Files","title":"CLAUDE.md — AMR R Package","text":"Pre-compiled data/ (edit directly; regenerate via data-raw/ scripts):","code":""},{"path":"https://amr-for-r.org/CLAUDE.html","id":"zero-dependency-design","dir":"","previous_headings":"","what":"Zero-Dependency Design","title":"CLAUDE.md — AMR R Package","text":"package Imports DESCRIPTION. optional integrations (ggplot2, dplyr, data.table, tidymodels, cli, crayon, etc.) listed Suggests guarded : Never add packages Imports. new functionality requires external package, add Suggests guard usage appropriately.","code":"if (requireNamespace(\"pkg\", quietly = TRUE)) { ... }"},{"path":"https://amr-for-r.org/CLAUDE.html","id":"testing","dir":"","previous_headings":"","what":"Testing","title":"CLAUDE.md — AMR R Package","text":"Framework: testthat (R ≥ 3.1); legacy tinytest used R 3.0–3.6 CI Test files: tests/testthat/test-*.R Helpers: tests/testthat/helper-functions.R CI matrix: GitHub Actions across Windows / macOS / Linux × R devel / release / oldrel-1 oldrel-4 Coverage: covr (files excluded: atc_online.R, mo_source.R, translate.R, resistance_predict.R, zz_deprecated.R, helper files, zzz.R)","code":""},{"path":"https://amr-for-r.org/CLAUDE.html","id":"documentation","dir":"","previous_headings":"","what":"Documentation","title":"CLAUDE.md — AMR R Package","text":"exported functions use roxygen2 blocks (RoxygenNote: 7.3.3, markdown enabled) Run devtools::document() change roxygen comments Never edit files man/ directly — auto-generated Vignettes live vignettes/ .Rmd files pkgdown website configured _pkgdown.yml","code":""},{"path":"https://amr-for-r.org/CLAUDE.html","id":"versioning","dir":"","previous_headings":"","what":"Versioning","title":"CLAUDE.md — AMR R Package","text":"Version format: major.minor.patch.dev (e.g., 3.0.1.9021) Development versions use .9xxx suffix Stable CRAN releases drop dev suffix (e.g., 3.0.1) NEWS.md uses sections New, Fixes, Updates GitHub issue references (#NNN)","code":""},{"path":"https://amr-for-r.org/CLAUDE.html","id":"version-and-date-bump-required-for-every-pr","dir":"","previous_headings":"Versioning","what":"Version and date bump required for every PR","title":"CLAUDE.md — AMR R Package","text":"PRs squash-merged, PR lands exactly one commit default branch. Version numbers kept sync cumulative commit count since last released tag. Therefore exactly one version bump allowed per PR, regardless many intermediate commits made branch.","code":""},{"path":"https://amr-for-r.org/CLAUDE.html","id":"computing-the-correct-version-number","dir":"","previous_headings":"Versioning > Version and date bump required for every PR","what":"Computing the correct version number","title":"CLAUDE.md — AMR R Package","text":"First, ensure git gh installed — required version computation pushing changes. Install missing anything else: run following repo root determine version string use: + 1 accounts fact PR’s squash commit yet default branch. Set files resulting version string (per PR, even across multiple commits): DESCRIPTION — Version: field NEWS.md — replace line 1 (# AMR heading) new version number; create new section. NEWS.md continuous log entire current x.y.z.9nnn development series: changes since last stable release accumulate single heading. updating line 1, append new change bullet appropriate sub-heading (### New, ### Fixes, ### Updates). Style rules NEWS.md entries: extremely concise — one short line per item end full stop (period) verbose explanations; just essential fact git describe fails (e.g. tags exist environment), fall back reading current version DESCRIPTION adding 1 last numeric component — bump already made PR.","code":"which git || apt-get install -y git which gh || apt-get install -y gh # Also ensure all tags are fetched so git describe works git fetch --tags currenttag=$(git describe --tags --abbrev=0 | sed 's/v//') currenttagfull=$(git describe --tags --abbrev=0) defaultbranch=$(git branch | cut -c 3- | grep -E '^master$|^main$') currentcommit=$(git rev-list --count ${currenttagfull}..${defaultbranch}) currentversion=\"${currenttag}.$((currentcommit + 9001 + 1))\" echo \"$currentversion\""},{"path":"https://amr-for-r.org/CLAUDE.html","id":"date-field","dir":"","previous_headings":"Versioning > Version and date bump required for every PR","what":"Date field","title":"CLAUDE.md — AMR R Package","text":"Date: field DESCRIPTION must reflect date last commit PR (first), ISO format. Update every commit always current:","code":"Date: 2026-03-07"},{"path":"https://amr-for-r.org/CLAUDE.html","id":"internal-state","dir":"","previous_headings":"","what":"Internal State","title":"CLAUDE.md — AMR R Package","text":"package uses private AMR_env environment (created aa_globals.R) caching expensive lookups (e.g., microorganism matching scores, breakpoint tables). avoids re-computation within session.","code":""},{"path":"https://amr-for-r.org/articles/AMR.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Conduct AMR data analysis","text":"Conducting AMR data analysis unfortunately requires -depth knowledge different scientific fields, makes hard right. least, requires: Good questions (always start !) reliable data thorough understanding (clinical) epidemiology, understand clinical epidemiological relevance possible bias results thorough understanding (clinical) microbiology/infectious diseases, understand microorganisms causal infections implications pharmaceutical treatment, well understanding intrinsic acquired microbial resistance Experience data analysis microbiological tests results, understand determination limitations MIC values interpretations SIR values Availability biological taxonomy microorganisms probably normalisation factors pharmaceuticals, defined daily doses (DDD) Available (inter-)national guidelines, profound methods apply course, instantly provide knowledge experience. AMR package, aimed providing (1) tools simplify antimicrobial resistance data cleaning, transformation analysis, (2) methods easily incorporate international guidelines (3) scientifically reliable reference data, including requirements mentioned . AMR package enables standardised reproducible AMR data analysis, application evidence-based rules, determination first isolates, translation various codes microorganisms antimicrobial drugs, determination (multi-drug) resistant microorganisms, calculation antimicrobial resistance, prevalence future trends.","code":""},{"path":"https://amr-for-r.org/articles/AMR.html","id":"preparation","dir":"Articles","previous_headings":"","what":"Preparation","title":"Conduct AMR data analysis","text":"tutorial, create fake demonstration data work . can skip Cleaning data already data ready. start analysis, try make structure data generally look like :","code":""},{"path":"https://amr-for-r.org/articles/AMR.html","id":"needed-r-packages","dir":"Articles","previous_headings":"Preparation","what":"Needed R packages","title":"Conduct AMR data analysis","text":"many uses R, need additional packages AMR data analysis. package works closely together tidyverse packages dplyr ggplot2 RStudio. tidyverse tremendously improves way conduct data science - allows natural way writing syntaxes creating beautiful plots R. also use cleaner package, can used cleaning data creating frequency tables. AMR package contains data set example_isolates_unclean, might look data users extracted laboratory systems: AMR data analysis, like microorganism column contain valid, --date taxonomy, antibiotic columns cleaned SIR values well.","code":"library(dplyr) library(ggplot2) library(AMR) # (if not yet installed, install with:) # install.packages(c(\"dplyr\", \"ggplot2\", \"AMR\")) example_isolates_unclean #> # A tibble: 3,000 × 8 #> patient_id hospital date bacteria AMX AMC CIP GEN #> #> 1 J3 A 2012-11-21 E. coli R I S S #> 2 R7 A 2018-04-03 K. pneumoniae R I S S #> 3 P3 A 2014-09-19 E. coli R S S S #> 4 P10 A 2015-12-10 E. coli S I S S #> 5 B7 A 2015-03-02 E. coli S S S S #> 6 W3 A 2018-03-31 S. aureus R S R S #> 7 J8 A 2016-06-14 E. coli R S S S #> 8 M3 A 2015-10-25 E. coli R S S S #> 9 J3 A 2019-06-19 E. coli S S S S #> 10 G6 A 2015-04-27 S. aureus S S S S #> # ℹ 2,990 more rows # we will use 'our_data' as the data set name for this tutorial our_data <- example_isolates_unclean"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"taxonomy-of-microorganisms","dir":"Articles","previous_headings":"Preparation","what":"Taxonomy of microorganisms","title":"Conduct AMR data analysis","text":".mo(), users can transform arbitrary microorganism names codes current taxonomy. AMR package contains --date taxonomic data. specific, currently included data retrieved 24 Jun 2024. codes AMR packages come .mo() short, still human readable. importantly, .mo() supports kinds input: first character codes denote taxonomic kingdom, Bacteria (B), Fungi (F), Protozoa (P). AMR package also contain functions directly retrieve taxonomic properties, name, genus, species, family, order, even Gram-stain. start mo_ use .mo() internally, still arbitrary user input can used: Now can thus clean data: Apparently, uncertainty translation taxonomic codes. Let’s check : ’s good.","code":"as.mo(\"Klebsiella pneumoniae\") #> Class #> [1] B_KLBSL_PNMN as.mo(\"K. pneumoniae\") #> Class #> [1] B_KLBSL_PNMN as.mo(\"KLEPNE\") #> Class #> [1] B_KLBSL_PNMN as.mo(\"KLPN\") #> Class #> [1] B_KLBSL_PNMN mo_family(\"K. pneumoniae\") #> [1] \"Enterobacteriaceae\" mo_genus(\"K. pneumoniae\") #> [1] \"Klebsiella\" mo_species(\"K. pneumoniae\") #> [1] \"pneumoniae\" mo_gramstain(\"Klebsiella pneumoniae\") #> [1] \"Gram-negative\" mo_ref(\"K. pneumoniae\") #> [1] \"Trevisan, 1887\" mo_snomed(\"K. pneumoniae\") #> [[1]] #> [1] \"1098101000112102\" \"446870005\" \"1098201000112108\" \"409801009\" #> [5] \"56415008\" \"714315002\" \"713926009\" our_data$bacteria <- as.mo(our_data$bacteria, info = TRUE) #> ℹ Retrieved values from the `microorganisms.codes` data set for \"ESCCOL\", #> \"KLEPNE\", \"STAAUR\", and \"STRPNE\". #> ℹ Microorganism translation was uncertain for four microorganisms. Run #> `mo_uncertainties()` to review these uncertainties, or use #> `add_custom_microorganisms()` to add custom entries. mo_uncertainties() #> Matching scores are based on the resemblance between the input and the full #> taxonomic name, and the pathogenicity in humans. See `mo_matching_score()`. #> Colour keys: 0.000-0.549 0.550-0.649 0.650-0.749 0.750-1.000 #> ------------------------------------------------------------------------------- #> \"E. coli\" -> Escherichia coli (B_ESCHR_COLI, 0.688) #> Also matched: Enterococcus crotali (0.650), Escherichia coli coli (0.643), #> Escherichia coli expressing (0.611), Enterobacter cowanii (0.600), Enterococcus #> columbae (0.595), Enterococcus camelliae (0.591), Enterococcus casseliflavus #> (0.577), Enterobacter cloacae cloacae (0.571), Enterobacter cloacae complex #> (0.571), and Enterobacter cloacae dissolvens (0.565) #> ------------------------------------------------------------------------------- #> \"K. pneumoniae\" -> Klebsiella pneumoniae (B_KLBSL_PNMN, 0.786) #> Also matched: Klebsiella pneumoniae complex (0.707), Klebsiella pneumoniae #> ozaenae (0.707), Klebsiella pneumoniae pneumoniae (0.688), Klebsiella #> pneumoniae rhinoscleromatis (0.658), Klebsiella pasteurii (0.500), Klebsiella #> planticola (0.500), Kingella potus (0.400), Kluyveromyces pseudotropicale #> (0.386), Kluyveromyces pseudotropicalis (0.363), and Kosakonia pseudosacchari #> (0.361) #> ------------------------------------------------------------------------------- #> \"S. aureus\" -> Staphylococcus aureus (B_STPHY_AURS, 0.690) #> Also matched: Staphylococcus aureus aureus (0.643), Staphylococcus argenteus #> (0.625), Staphylococcus aureus anaerobius (0.625), Staphylococcus auricularis #> (0.615), Salmonella Aurelianis (0.595), Salmonella Aarhus (0.588), Salmonella #> Amounderness (0.587), Staphylococcus argensis (0.587), Streptococcus australis #> (0.587), and Salmonella choleraesuis arizonae (0.562) #> ------------------------------------------------------------------------------- #> \"S. pneumoniae\" -> Streptococcus pneumoniae (B_STRPT_PNMN, 0.750) #> Also matched: Streptococcus pseudopneumoniae (0.700), Streptococcus phocae #> salmonis (0.552), Serratia proteamaculans quinovora (0.545), Streptococcus #> pseudoporcinus (0.536), Staphylococcus piscifermentans (0.533), Staphylococcus #> pseudintermedius (0.532), Serratia proteamaculans proteamaculans (0.526), #> Streptococcus gallolyticus pasteurianus (0.526), Salmonella Portanigra (0.524), #> and Streptococcus periodonticum (0.519) #> ℹ Only the first 10 other matches of each record are shown. Run `` #> `print(mo_uncertainties(), n = ...)` `` to view more entries, or save #> `mo_uncertainties()` to an object."},{"path":"https://amr-for-r.org/articles/AMR.html","id":"antibiotic-results","dir":"Articles","previous_headings":"Preparation","what":"Antibiotic results","title":"Conduct AMR data analysis","text":"column antibiotic test results must also cleaned. AMR package comes three new data types work test results: mic minimal inhibitory concentrations (MIC), disk disk diffusion diameters, sir SIR data interpreted already. package can also determine SIR values based MIC disk diffusion values, read .sir() page. now, just clean SIR columns data using dplyr: basically cleaning, time start data inclusion.","code":"# method 1, be explicit about the columns: our_data <- our_data %>% mutate_at(vars(AMX:GEN), as.sir) # method 2, let the AMR package determine the eligible columns our_data <- our_data %>% mutate_if(is_sir_eligible, as.sir) # result: our_data #> # A tibble: 3,000 × 8 #> patient_id hospital date bacteria AMX AMC CIP GEN #> #> 1 J3 A 2012-11-21 B_ESCHR_COLI R I S S #> 2 R7 A 2018-04-03 B_KLBSL_PNMN R I S S #> 3 P3 A 2014-09-19 B_ESCHR_COLI R S S S #> 4 P10 A 2015-12-10 B_ESCHR_COLI S I S S #> 5 B7 A 2015-03-02 B_ESCHR_COLI S S S S #> 6 W3 A 2018-03-31 B_STPHY_AURS R S R S #> 7 J8 A 2016-06-14 B_ESCHR_COLI R S S S #> 8 M3 A 2015-10-25 B_ESCHR_COLI R S S S #> 9 J3 A 2019-06-19 B_ESCHR_COLI S S S S #> 10 G6 A 2015-04-27 B_STPHY_AURS S S S S #> # ℹ 2,990 more rows"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"first-isolates","dir":"Articles","previous_headings":"Preparation","what":"First isolates","title":"Conduct AMR data analysis","text":"need know isolates can actually use analysis without repetition bias. conduct analysis antimicrobial resistance, must include first isolate every patient per episode (Hindler et al., Clin Infect Dis. 2007). , easily get overestimate underestimate resistance antibiotic. Imagine patient admitted MRSA found 5 different blood cultures following weeks (yes, countries like Netherlands blood drawing policies). resistance percentage oxacillin isolates overestimated, included MRSA . clearly selection bias. Clinical Laboratory Standards Institute (CLSI) appoints follows: (…) preparing cumulative antibiogram guide clinical decisions empirical antimicrobial therapy initial infections, first isolate given species per patient, per analysis period (eg, one year) included, irrespective body site, antimicrobial susceptibility profile, phenotypical characteristics (eg, biotype). first isolate easily identified, cumulative antimicrobial susceptibility test data prepared using first isolate generally comparable cumulative antimicrobial susceptibility test data calculated methods, providing duplicate isolates excluded. M39-A4 Analysis Presentation Cumulative Antimicrobial Susceptibility Test Data, 4th Edition. CLSI, 2014. Chapter 6.4 AMR package includes methodology first_isolate() function able apply four different methods defined Hindler et al. 2007: phenotype-based, episode-based, patient-based, isolate-based. right method depends goals analysis, default phenotype-based method case method properly correct duplicate isolates. Read methods first_isolate() page. outcome function can easily added data: 91% suitable resistance analysis! can now filter filter() function, also dplyr package: future use, two syntaxes can shortened: end 2 724 isolates analysis. Now data looks like: Time analysis.","code":"our_data <- our_data %>% mutate(first = first_isolate(info = TRUE)) #> ℹ Determining first isolates using an episode length of 365 days #> ℹ Using column bacteria as input for `col_mo`. #> ℹ Column first is SIR eligible (despite only having empty values), since it #> seems to be cefozopran (ZOP) #> ℹ Using column date as input for `col_date`. #> ℹ Using column patient_id as input for `col_patient_id`. #> ℹ Basing inclusion on all antimicrobial results, using a points threshold of 2 #> => Found 2,724 'phenotype-based' first isolates (90.8% of total where a #> microbial ID was available) our_data_1st <- our_data %>% filter(first == TRUE) our_data_1st <- our_data %>% filter_first_isolate() our_data_1st #> # A tibble: 2,724 × 9 #> patient_id hospital date bacteria AMX AMC CIP GEN first #> #> 1 J3 A 2012-11-21 B_ESCHR_COLI R I S S TRUE #> 2 R7 A 2018-04-03 B_KLBSL_PNMN R I S S TRUE #> 3 P3 A 2014-09-19 B_ESCHR_COLI R S S S TRUE #> 4 P10 A 2015-12-10 B_ESCHR_COLI S I S S TRUE #> 5 B7 A 2015-03-02 B_ESCHR_COLI S S S S TRUE #> 6 W3 A 2018-03-31 B_STPHY_AURS R S R S TRUE #> 7 M3 A 2015-10-25 B_ESCHR_COLI R S S S TRUE #> 8 J3 A 2019-06-19 B_ESCHR_COLI S S S S TRUE #> 9 G6 A 2015-04-27 B_STPHY_AURS S S S S TRUE #> 10 P4 A 2011-06-21 B_ESCHR_COLI S S S S TRUE #> # ℹ 2,714 more rows"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"analysing-the-data","dir":"Articles","previous_headings":"","what":"Analysing the data","title":"Conduct AMR data analysis","text":"base R summary() function gives good first impression, comes support new mo sir classes now data set:","code":"summary(our_data_1st) #> patient_id hospital date bacteria #> Length :2724 Length :2724 Min. :2011-01-01 Class :mo #> N.unique : 260 N.unique : 3 1st Qu.:2013-04-07 :0 #> N.blank : 0 N.blank : 0 Median :2015-06-03 Unique:4 #> Min.nchar: 2 Min.nchar: 1 Mean :2015-06-09 #1 :B_ESCHR_COLI #> Max.nchar: 3 Max.nchar: 1 3rd Qu.:2017-08-11 #2 :B_STPHY_AURS #> Max. :2019-12-27 #3 :B_STRPT_PNMN #> AMX AMC CIP #> Class:sir Class:sir Class:sir #> %S :41.6% (n=1133) %S :52.6% (n=1432) %S :52.5% (n=1431) #> %SDD : 0.0% (n=0) %SDD : 0.0% (n=0) %SDD : 0.0% (n=0) #> %I :16.4% (n=446) %I :12.2% (n=333) %I : 6.5% (n=176) #> %R :42.0% (n=1145) %R :35.2% (n=959) %R :41.0% (n=1117) #> %NI : 0.0% (n=0) %NI : 0.0% (n=0) %NI : 0.0% (n=0) #> GEN first #> Class:sir Mode:logical #> %S :61.0% (n=1661) TRUE:2724 #> %SDD : 0.0% (n=0) #> %I : 3.0% (n=82) #> %R :36.0% (n=981) #> %NI : 0.0% (n=0) glimpse(our_data_1st) #> Rows: 2,724 #> Columns: 9 #> $ patient_id \"J3\", \"R7\", \"P3\", \"P10\", \"B7\", \"W3\", \"M3\", \"J3\", \"G6\", \"P4\"… #> $ hospital \"A\", \"A\", \"A\", \"A\", \"A\", \"A\", \"A\", \"A\", \"A\", \"A\", \"A\", \"A\",… #> $ date 2012-11-21, 2018-04-03, 2014-09-19, 2015-12-10, 2015-03-02… #> $ bacteria \"B_ESCHR_COLI\", \"B_KLBSL_PNMN\", \"B_ESCHR_COLI\", \"B_ESCHR_COL… #> $ AMX R, R, R, S, S, R, R, S, S, S, S, R, S, S, R, R, R, R, S, R,… #> $ AMC I, I, S, I, S, S, S, S, S, S, S, S, S, S, S, S, S, R, S, S,… #> $ CIP S, S, S, S, S, R, S, S, S, S, S, S, S, S, S, S, S, S, S, S,… #> $ GEN S, S, S, S, S, S, S, S, S, S, S, R, S, S, S, S, S, S, S, S,… #> $ first TRUE, TRUE, TRUE, TRUE, TRUE, TRUE, TRUE, TRUE, TRUE, TRUE,… # number of unique values per column: sapply(our_data_1st, n_distinct) #> patient_id hospital date bacteria AMX AMC CIP #> 260 3 1854 4 3 3 3 #> GEN first #> 3 1"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"availability-of-species","dir":"Articles","previous_headings":"Analysing the data","what":"Availability of species","title":"Conduct AMR data analysis","text":"just get idea species distributed, create frequency table count() based name microorganisms:","code":"our_data %>% count(mo_name(bacteria), sort = TRUE) #> # A tibble: 4 × 2 #> `mo_name(bacteria)` n #> #> 1 Escherichia coli 1518 #> 2 Staphylococcus aureus 730 #> 3 Streptococcus pneumoniae 426 #> 4 Klebsiella pneumoniae 326 our_data_1st %>% count(mo_name(bacteria), sort = TRUE) #> # A tibble: 4 × 2 #> `mo_name(bacteria)` n #> #> 1 Escherichia coli 1321 #> 2 Staphylococcus aureus 682 #> 3 Streptococcus pneumoniae 402 #> 4 Klebsiella pneumoniae 319"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"select-and-filter-with-antibiotic-selectors","dir":"Articles","previous_headings":"Analysing the data","what":"Select and filter with antibiotic selectors","title":"Conduct AMR data analysis","text":"Using -called antibiotic class selectors, can select filter columns based antibiotic class antibiotic results :","code":"our_data_1st %>% select(date, aminoglycosides()) #> ℹ For `aminoglycosides()` using column GEN #> (gentamicin) #> # A tibble: 2,724 × 2 #> date GEN #> #> 1 2012-11-21 S #> 2 2018-04-03 S #> 3 2014-09-19 S #> 4 2015-12-10 S #> 5 2015-03-02 S #> 6 2018-03-31 S #> 7 2015-10-25 S #> 8 2019-06-19 S #> 9 2015-04-27 S #> 10 2011-06-21 S #> # ℹ 2,714 more rows our_data_1st %>% select(bacteria, betalactams()) #> ℹ For `betalactams()` using columns AMX (amoxicillin) and AMC #> (amoxicillin/clavulanic acid) #> # A tibble: 2,724 × 3 #> bacteria AMX AMC #> #> 1 B_ESCHR_COLI R I #> 2 B_KLBSL_PNMN R I #> 3 B_ESCHR_COLI R S #> 4 B_ESCHR_COLI S I #> 5 B_ESCHR_COLI S S #> 6 B_STPHY_AURS R S #> 7 B_ESCHR_COLI R S #> 8 B_ESCHR_COLI S S #> 9 B_STPHY_AURS S S #> 10 B_ESCHR_COLI S S #> # ℹ 2,714 more rows our_data_1st %>% select(bacteria, where(is.sir)) #> # A tibble: 2,724 × 5 #> bacteria AMX AMC CIP GEN #> #> 1 B_ESCHR_COLI R I S S #> 2 B_KLBSL_PNMN R I S S #> 3 B_ESCHR_COLI R S S S #> 4 B_ESCHR_COLI S I S S #> 5 B_ESCHR_COLI S S S S #> 6 B_STPHY_AURS R S R S #> 7 B_ESCHR_COLI R S S S #> 8 B_ESCHR_COLI S S S S #> 9 B_STPHY_AURS S S S S #> 10 B_ESCHR_COLI S S S S #> # ℹ 2,714 more rows # filtering using AB selectors is also possible: our_data_1st %>% filter(any(aminoglycosides() == \"R\")) #> ℹ For `aminoglycosides()` using column GEN #> (gentamicin) #> # A tibble: 981 × 9 #> patient_id hospital date bacteria AMX AMC CIP GEN first #> #> 1 J5 A 2017-12-25 B_STRPT_PNMN R S S R TRUE #> 2 X1 A 2017-07-04 B_STPHY_AURS R S S R TRUE #> 3 B3 A 2016-07-24 B_ESCHR_COLI S S S R TRUE #> 4 V7 A 2012-04-03 B_ESCHR_COLI S S S R TRUE #> 5 C9 A 2017-03-23 B_ESCHR_COLI S S S R TRUE #> 6 R1 A 2018-06-10 B_STPHY_AURS S S S R TRUE #> 7 S2 A 2013-07-19 B_STRPT_PNMN S S S R TRUE #> 8 P5 A 2019-03-09 B_STPHY_AURS S S S R TRUE #> 9 Q8 A 2019-08-10 B_STPHY_AURS S S S R TRUE #> 10 K5 A 2013-03-15 B_STRPT_PNMN S S S R TRUE #> # ℹ 971 more rows our_data_1st %>% filter(all(betalactams() == \"R\")) #> ℹ For `betalactams()` using columns AMX (amoxicillin) and AMC #> (amoxicillin/clavulanic acid) #> # A tibble: 462 × 9 #> patient_id hospital date bacteria AMX AMC CIP GEN first #> #> 1 M7 A 2013-07-22 B_STRPT_PNMN R R S S TRUE #> 2 R10 A 2013-12-20 B_STPHY_AURS R R S S TRUE #> 3 R7 A 2015-10-25 B_STPHY_AURS R R S S TRUE #> 4 R8 A 2019-10-25 B_STPHY_AURS R R S S TRUE #> 5 B6 A 2016-11-20 B_ESCHR_COLI R R R R TRUE #> 6 I7 A 2015-08-19 B_ESCHR_COLI R R S S TRUE #> 7 N3 A 2014-12-29 B_STRPT_PNMN R R R S TRUE #> 8 Q2 A 2019-09-22 B_ESCHR_COLI R R S S TRUE #> 9 X7 A 2011-03-20 B_ESCHR_COLI R R S R TRUE #> 10 V1 A 2018-08-07 B_STPHY_AURS R R S S TRUE #> # ℹ 452 more rows # even works in base R (since R 3.0): our_data_1st[all(betalactams() == \"R\"), ] #> ℹ For `betalactams()` using columns AMX (amoxicillin) and AMC #> (amoxicillin/clavulanic acid) #> # A tibble: 462 × 9 #> patient_id hospital date bacteria AMX AMC CIP GEN first #> #> 1 M7 A 2013-07-22 B_STRPT_PNMN R R S S TRUE #> 2 R10 A 2013-12-20 B_STPHY_AURS R R S S TRUE #> 3 R7 A 2015-10-25 B_STPHY_AURS R R S S TRUE #> 4 R8 A 2019-10-25 B_STPHY_AURS R R S S TRUE #> 5 B6 A 2016-11-20 B_ESCHR_COLI R R R R TRUE #> 6 I7 A 2015-08-19 B_ESCHR_COLI R R S S TRUE #> 7 N3 A 2014-12-29 B_STRPT_PNMN R R R S TRUE #> 8 Q2 A 2019-09-22 B_ESCHR_COLI R R S S TRUE #> 9 X7 A 2011-03-20 B_ESCHR_COLI R R S R TRUE #> 10 V1 A 2018-08-07 B_STPHY_AURS R R S S TRUE #> # ℹ 452 more rows"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"generate-antibiograms","dir":"Articles","previous_headings":"Analysing the data","what":"Generate antibiograms","title":"Conduct AMR data analysis","text":"Since AMR v2.0 (March 2023), easy create different types antibiograms, support 20 different languages. four antibiogram types, proposed Klinker et al. (2021, DOI 10.1177/20499361211011373), supported new antibiogram() function: Traditional Antibiogram (TA) e.g, susceptibility Pseudomonas aeruginosa piperacillin/tazobactam (TZP) Combination Antibiogram (CA) e.g, sdditional susceptibility Pseudomonas aeruginosa TZP + tobramycin versus TZP alone Syndromic Antibiogram (SA) e.g, susceptibility Pseudomonas aeruginosa TZP among respiratory specimens (obtained among ICU patients ) Weighted-Incidence Syndromic Combination Antibiogram (WISCA) e.g, susceptibility Pseudomonas aeruginosa TZP among respiratory specimens (obtained among ICU patients ) male patients age >=65 years heart failure section, show use antibiogram() function create antibiogram types. starters, included example_isolates data set looks like:","code":"example_isolates #> # A tibble: 2,000 × 46 #> date patient age gender ward mo PEN OXA FLC AMX #> #> 1 2002-01-02 A77334 65 F Clinical B_ESCHR_COLI R NA NA NA #> 2 2002-01-03 A77334 65 F Clinical B_ESCHR_COLI R NA NA NA #> 3 2002-01-07 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 4 2002-01-07 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 5 2002-01-13 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 6 2002-01-13 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 7 2002-01-14 462729 78 M Clinical B_STPHY_AURS R NA S R #> 8 2002-01-14 462729 78 M Clinical B_STPHY_AURS R NA S R #> 9 2002-01-16 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 10 2002-01-17 858515 79 F ICU B_STPHY_EPDR R NA S NA #> # ℹ 1,990 more rows #> # ℹ 36 more variables: AMC , AMP , TZP , CZO , FEP , #> # CXM , FOX , CTX , CAZ , CRO , GEN , #> # TOB , AMK , KAN , TMP , SXT , NIT , #> # FOS , LNZ , CIP , MFX , VAN , TEC , #> # TCY , TGC , DOX , ERY , CLI , AZM , #> # IPM , MEM , MTR , CHL , COL , MUP , …"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"traditional-antibiogram","dir":"Articles","previous_headings":"Analysing the data > Generate antibiograms","what":"Traditional Antibiogram","title":"Conduct AMR data analysis","text":"create traditional antibiogram, simply state antibiotics used. antibiotics argument antibiogram() function supports (combination) previously mentioned antibiotic class selectors: Notice antibiogram() function automatically prints right format using Quarto R Markdown (page), even applies italics taxonomic names (using italicise_taxonomy() internally). also uses language OS either English, Arabic, Bengali, Chinese, Czech, Danish, Dutch, Finnish, French, German, Greek, Hindi, Indonesian, Italian, Japanese, Korean, Norwegian, Polish, Portuguese, Romanian, Russian, Spanish, Swahili, Swedish, Turkish, Ukrainian, Urdu, Vietnamese. next example, force language Spanish using language argument:","code":"antibiogram(example_isolates, antibiotics = c(aminoglycosides(), carbapenems()) ) #> ℹ For `aminoglycosides()` using columns GEN (gentamicin), TOB (tobramycin), AMK #> (amikacin), and KAN (kanamycin) #> ℹ For `carbapenems()` using columns IPM (imipenem) and MEM (meropenem) antibiogram(example_isolates, mo_transform = \"gramstain\", antibiotics = aminoglycosides(), ab_transform = \"name\", language = \"es\" ) #> ℹ For `aminoglycosides()` using columns GEN (gentamicin), TOB (tobramycin), AMK #> (amikacin), and KAN (kanamycin)"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"combined-antibiogram","dir":"Articles","previous_headings":"Analysing the data > Generate antibiograms","what":"Combined Antibiogram","title":"Conduct AMR data analysis","text":"create combined antibiogram, use antibiotic codes names plus + character like :","code":"combined_ab <- antibiogram(example_isolates, antibiotics = c(\"TZP\", \"TZP+TOB\", \"TZP+GEN\"), ab_transform = NULL ) combined_ab"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"syndromic-antibiogram","dir":"Articles","previous_headings":"Analysing the data > Generate antibiograms","what":"Syndromic Antibiogram","title":"Conduct AMR data analysis","text":"create syndromic antibiogram, syndromic_group argument must used. can column data, e.g. ifelse() calculations based certain columns:","code":"antibiogram(example_isolates, antibiotics = c(aminoglycosides(), carbapenems()), syndromic_group = \"ward\" ) #> ℹ For `aminoglycosides()` using columns GEN (gentamicin), TOB (tobramycin), AMK #> (amikacin), and KAN (kanamycin) #> ℹ For `carbapenems()` using columns IPM (imipenem) and MEM (meropenem)"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"weighted-incidence-syndromic-combination-antibiogram-wisca","dir":"Articles","previous_headings":"Analysing the data > Generate antibiograms","what":"Weighted-Incidence Syndromic Combination Antibiogram (WISCA)","title":"Conduct AMR data analysis","text":"create Weighted-Incidence Syndromic Combination Antibiogram (WISCA), simply set wisca = TRUE antibiogram() function, use dedicated wisca() function. Unlike traditional antibiograms, WISCA provides syndrome-based susceptibility estimates, weighted pathogen incidence antimicrobial susceptibility patterns. WISCA uses Bayesian decision model integrate data multiple pathogens, improving empirical therapy guidance, especially low-incidence infections. pathogen-agnostic, meaning results syndrome-based rather stratified microorganism. reliable results, ensure data includes first isolates (use first_isolate()) consider filtering top n species (use top_n_microorganisms()), WISCA outcomes meaningful based robust incidence estimates. patient- syndrome-specific WISCA, run function grouped tibble, .e., using group_by() first:","code":"example_isolates %>% wisca( antibiotics = c(\"TZP\", \"TZP+TOB\", \"TZP+GEN\"), minimum = 10 ) # Recommended threshold: ≥30 example_isolates %>% top_n_microorganisms(n = 10) %>% group_by( age_group = age_groups(age, c(25, 50, 75)), gender ) %>% wisca(antibiotics = c(\"TZP\", \"TZP+TOB\", \"TZP+GEN\"))"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"plotting-antibiograms","dir":"Articles","previous_headings":"Analysing the data > Generate antibiograms","what":"Plotting antibiograms","title":"Conduct AMR data analysis","text":"Antibiograms can plotted using autoplot() ggplot2 packages, since AMR package provides extension function: calculate antimicrobial resistance sensible way, also correcting results, use resistance() susceptibility() functions.","code":"autoplot(combined_ab)"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"resistance-percentages","dir":"Articles","previous_headings":"Analysing the data","what":"Resistance percentages","title":"Conduct AMR data analysis","text":"functions resistance() susceptibility() can used calculate antimicrobial resistance susceptibility. specific analyses, functions proportion_S(), proportion_SI(), proportion_I(), proportion_IR() proportion_R() can used determine proportion specific antimicrobial outcome. functions contain minimum argument, denoting minimum required number test results returning value. functions otherwise return NA. default minimum = 30, following CLSI M39-A4 guideline applying microbial epidemiology. per EUCAST guideline 2019, calculate resistance proportion R (proportion_R(), equal resistance()) susceptibility proportion S (proportion_SI(), equal susceptibility()). functions can used : can used conjunction group_by() summarise(), dplyr package:","code":"our_data_1st %>% resistance(AMX) #> ℹ `resistance()` assumes the EUCAST guideline and thus considers the 'I' #> category susceptible. Set the `guideline` argument or the `AMR_guideline` #> option to either \"CLSI\" or \"EUCAST\", see `?AMR-options`. #> ℹ This message will be shown once per session. #> [1] 0.4203377 our_data_1st %>% group_by(hospital) %>% summarise(amoxicillin = resistance(AMX)) #> # A tibble: 3 × 2 #> hospital amoxicillin #> #> 1 A 0.340 #> 2 B 0.551 #> 3 C 0.370"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"interpreting-mic-and-disk-diffusion-values","dir":"Articles","previous_headings":"Analysing the data","what":"Interpreting MIC and Disk Diffusion Values","title":"Conduct AMR data analysis","text":"Minimal inhibitory concentration (MIC) values disk diffusion diameters can interpreted clinical breakpoints (SIR) using .sir(). ’s example randomly generated MIC values Klebsiella pneumoniae ciprofloxacin: allows direct interpretation according EUCAST CLSI breakpoints, facilitating automated AMR data processing.","code":"set.seed(123) mic_values <- random_mic(100) sir_values <- as.sir(mic_values, mo = \"K. pneumoniae\", ab = \"cipro\", guideline = \"EUCAST 2024\") my_data <- tibble(MIC = mic_values, SIR = sir_values) my_data #> # A tibble: 100 × 2 #> MIC SIR #> #> 1 <=0.0001 S #> 2 0.0160 S #> 3 >=8.0000 R #> 4 0.0320 S #> 5 0.0080 S #> 6 64.0000 R #> 7 0.0080 S #> 8 0.1250 S #> 9 0.0320 S #> 10 0.0002 S #> # ℹ 90 more rows"},{"path":"https://amr-for-r.org/articles/AMR.html","id":"plotting-mic-and-sir-interpretations","dir":"Articles","previous_headings":"Analysing the data","what":"Plotting MIC and SIR Interpretations","title":"Conduct AMR data analysis","text":"can visualise MIC distributions SIR interpretations using ggplot2, using new scale_y_mic() y-axis scale_colour_sir() colour-code SIR categories. plot provides intuitive way assess susceptibility patterns across different groups incorporating clinical breakpoints. straightforward less manual approach, ggplot2’s function autoplot() extended package directly plot MIC disk diffusion values: Author: Dr. Matthijs Berends, 23rd Feb 2025","code":"# add a group my_data$group <- rep(c(\"A\", \"B\", \"C\", \"D\"), each = 25) ggplot( my_data, aes(x = group, y = MIC, colour = SIR) ) + geom_jitter(width = 0.2, size = 2) + geom_boxplot(fill = NA, colour = \"grey40\") + scale_y_mic() + scale_colour_sir() + labs( title = \"MIC Distribution and SIR Interpretation\", x = \"Sample Groups\", y = \"MIC (mg/L)\" ) autoplot(mic_values) # by providing `mo` and `ab`, colours will indicate the SIR interpretation: autoplot(mic_values, mo = \"K. pneumoniae\", ab = \"cipro\", guideline = \"EUCAST 2024\")"},{"path":"https://amr-for-r.org/articles/AMR_for_Python.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"AMR for Python","text":"AMR package R powerful tool antimicrobial resistance (AMR) analysis. provides extensive features handling microbial antimicrobial data. However, work primarily Python, now intuitive option available: AMR Python package. Python package wrapper around AMR R package. uses rpy2 package internally. Despite need R installed, Python users can now easily work AMR data directly Python code.","code":""},{"path":"https://amr-for-r.org/articles/AMR_for_Python.html","id":"prerequisites","dir":"Articles","previous_headings":"","what":"Prerequisites","title":"AMR for Python","text":"package tested virtual environment (venv). can set environment running: can activate environment, venv ready work .","code":"# linux and macOS: python -m venv /path/to/new/virtual/environment # Windows: python -m venv C:\\path\\to\\new\\virtual\\environment"},{"path":"https://amr-for-r.org/articles/AMR_for_Python.html","id":"install-amr","dir":"Articles","previous_headings":"","what":"Install AMR","title":"AMR for Python","text":"Since Python package available official Python Package Index, can just run: Make sure R installed. need install AMR R package, installed automatically. Linux: macOS (using Homebrew): Windows, visit CRAN download page download install R.","code":"pip install AMR # Ubuntu / Debian sudo apt install r-base # Fedora: sudo dnf install R # CentOS/RHEL sudo yum install R brew install r"},{"path":[]},{"path":"https://amr-for-r.org/articles/AMR_for_Python.html","id":"cleaning-taxonomy","dir":"Articles","previous_headings":"Examples of Usage","what":"Cleaning Taxonomy","title":"AMR for Python","text":"’s example demonstrates clean microorganism drug names using AMR Python package:","code":"import pandas as pd import AMR # Sample data data = { \"MOs\": ['E. coli', 'ESCCOL', 'esco', 'Esche coli'], \"Drug\": ['Cipro', 'CIP', 'J01MA02', 'Ciproxin'] } df = pd.DataFrame(data) # Use AMR functions to clean microorganism and drug names df['MO_clean'] = AMR.mo_name(df['MOs']) df['Drug_clean'] = AMR.ab_name(df['Drug']) # Display the results print(df)"},{"path":"https://amr-for-r.org/articles/AMR_for_Python.html","id":"explanation","dir":"Articles","previous_headings":"Examples of Usage > Cleaning Taxonomy","what":"Explanation","title":"AMR for Python","text":"mo_name: function standardises microorganism names. , different variations Escherichia coli (“E. coli”, “ESCCOL”, “esco”, “Esche coli”) converted correct, standardised form, “Escherichia coli”. ab_name: Similarly, function standardises antimicrobial names. different representations ciprofloxacin (e.g., “Cipro”, “CIP”, “J01MA02”, “Ciproxin”) converted standard name, “Ciprofloxacin”.","code":""},{"path":"https://amr-for-r.org/articles/AMR_for_Python.html","id":"calculating-amr","dir":"Articles","previous_headings":"Examples of Usage","what":"Calculating AMR","title":"AMR for Python","text":"","code":"import AMR import pandas as pd df = AMR.example_isolates result = AMR.resistance(df[\"AMX\"]) print(result) [0.59555556]"},{"path":"https://amr-for-r.org/articles/AMR_for_Python.html","id":"generating-antibiograms","dir":"Articles","previous_headings":"Examples of Usage","what":"Generating Antibiograms","title":"AMR for Python","text":"One core functions AMR package generating antibiogram, table summarises antimicrobial susceptibility bacterial isolates. ’s can generate antibiogram Python: example, generate antibiogram selecting various antibiotics.","code":"result2a = AMR.antibiogram(df[[\"mo\", \"AMX\", \"CIP\", \"TZP\"]]) print(result2a) result2b = AMR.antibiogram(df[[\"mo\", \"AMX\", \"CIP\", \"TZP\"]], mo_transform = \"gramstain\") print(result2b)"},{"path":"https://amr-for-r.org/articles/AMR_for_Python.html","id":"taxonomic-data-sets-now-in-python","dir":"Articles","previous_headings":"Examples of Usage","what":"Taxonomic Data Sets Now in Python!","title":"AMR for Python","text":"Python user, might like important data sets AMR R package, microorganisms, antimicrobials, clinical_breakpoints, example_isolates, now available regular Python data frames:","code":"AMR.microorganisms AMR.antimicrobials"},{"path":"https://amr-for-r.org/articles/AMR_for_Python.html","id":"conclusion","dir":"Articles","previous_headings":"","what":"Conclusion","title":"AMR for Python","text":"AMR Python package, Python users can now effortlessly call R functions AMR R package. eliminates need complex rpy2 configurations provides clean, easy--use interface antimicrobial resistance analysis. examples provided demonstrate can applied typical workflows, standardising microorganism antimicrobial names calculating resistance. just running import AMR, users can seamlessly integrate robust features R AMR package Python workflows. Whether ’re cleaning data analysing resistance patterns, AMR Python package makes easy work AMR data Python.","code":""},{"path":"https://amr-for-r.org/articles/AMR_with_tidymodels.html","id":"example-1-using-antimicrobial-selectors","dir":"Articles","previous_headings":"","what":"Example 1: Using Antimicrobial Selectors","title":"AMR with tidymodels","text":"leveraging power tidymodels AMR package, ’ll build reproducible machine learning workflow predict Gramstain microorganism two important antibiotic classes: aminoglycosides beta-lactams.","code":""},{"path":"https://amr-for-r.org/articles/AMR_with_tidymodels.html","id":"objective","dir":"Articles","previous_headings":"Example 1: Using Antimicrobial Selectors","what":"Objective","title":"AMR with tidymodels","text":"goal build predictive model using tidymodels framework determine Gramstain microorganism based microbial data. : Preprocess data using selector functions aminoglycosides() betalactams(). Define logistic regression model prediction. Use structured tidymodels workflow preprocess, train, evaluate model.","code":""},{"path":"https://amr-for-r.org/articles/AMR_with_tidymodels.html","id":"data-preparation","dir":"Articles","previous_headings":"Example 1: Using Antimicrobial Selectors","what":"Data Preparation","title":"AMR with tidymodels","text":"begin loading required libraries preparing example_isolates dataset AMR package. Prepare data: Explanation: aminoglycosides() betalactams() dynamically select columns antimicrobials classes. drop_na() ensures model receives complete cases training.","code":"# Load required libraries library(AMR) # For AMR data analysis library(tidymodels) # For machine learning workflows, and data manipulation (dplyr, tidyr, ...) # Your data could look like this: example_isolates #> # A tibble: 2,000 × 46 #> date patient age gender ward mo PEN OXA FLC AMX #> #> 1 2002-01-02 A77334 65 F Clinical B_ESCHR_COLI R NA NA NA #> 2 2002-01-03 A77334 65 F Clinical B_ESCHR_COLI R NA NA NA #> 3 2002-01-07 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 4 2002-01-07 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 5 2002-01-13 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 6 2002-01-13 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 7 2002-01-14 462729 78 M Clinical B_STPHY_AURS R NA S R #> 8 2002-01-14 462729 78 M Clinical B_STPHY_AURS R NA S R #> 9 2002-01-16 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 10 2002-01-17 858515 79 F ICU B_STPHY_EPDR R NA S NA #> # ℹ 1,990 more rows #> # ℹ 36 more variables: AMC , AMP , TZP , CZO , FEP , #> # CXM , FOX , CTX , CAZ , CRO , GEN
From the shell:
# CRAN check from parent directory R CMD check AMR
clinical_breakpoints
as.sir()
recipes
NA
NA_ab_
NA_mo_
NA_character_
NA_integer_
reference_data
> breakpoint_R
< breakpoint_R
host = NA
parallel = TRUE
AMR_env
mclapply
sir_interpretation_history
%pm>%
pm_pull
as.sir.default
\u00a
"1"
as.mic()
"1e-3"
e
as.ab()
ETH
MTH
PHE
PHN
STH
THA
THI1
cli
mdro()
infer_from_combinations
TRUE
A data.frame to be used for interpretation, which defaults to the clinical_breakpoints data set. Changing this argument allows for using own interpretation guidelines. This argument must contain a data set that is equal in structure to the clinical_breakpoints data set (same column names and column types). Please note that the guideline argument will be ignored when reference_data is manually set.
guideline
A data.frame to be used for interpretation, which defaults to the clinical_breakpoints data set. Changing this argument allows for using own interpretation guidelines. This argument must have the same column names as the clinical_breakpoints data set. Column types are coerced automatically where possible: the mo column is passed through as.mo(), the ab column through as.ab(), and plain character, numeric, or logical columns are cast to the expected type. When reference_data is manually set, the guideline argument is optional: if omitted (or if its value does not match any row in the custom data), all rows in reference_data are considered. If guideline is set to a value that exists in the guideline column of the custom data, only matching rows are used — useful when a single custom table contains multiple guidelines. For the R classification, the EUCAST convention is used by default: MIC values > breakpoint_R and disk diffusion values < breakpoint_R are classified as R, with values between breakpoint_S and breakpoint_R classified as I (or SDD). Only when using the standard clinical_breakpoints with a CLSI guideline are the closed-interval rules (>= breakpoint_R for MIC, <= breakpoint_R for disk) applied; custom reference_data always uses the open-interval (EUCAST) convention regardless of the guideline name.
mo
as.mo()
ab
breakpoint_S
breakpoint_R
>= breakpoint_R
<= breakpoint_R
A logical to indicate if parallel computing must be used, defaults to FALSE. This requires no additional packages, as the used parallel package is part of base R. On Windows and on R < 4.0.0 parallel::parLapply() will be used, in all other cases the more efficient parallel::mclapply() will be used.
FALSE
parallel
parallel::parLapply()
parallel::mclapply()
A logical to indicate if parallel computing must be used, defaults to FALSE. The parallel package is part of base R and no additional packages are required. On Unix/macOS with R >= 4.0.0, parallel::mclapply() (fork-based) is used; on Windows and R < 4.0.0, parallel::parLapply() with a PSOCK cluster is used (requires the AMR package to be installed, not just loaded via devtools::load_all()). Parallelism distributes columns across cores; it is most beneficial when there are many antibiotic columns and a large number of rows.
devtools::load_all()