diff --git a/404.html b/404.html
index 4dff45a8..52df1245 100644
--- a/404.html
+++ b/404.html
@@ -36,7 +36,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/LICENSE-text.html b/LICENSE-text.html
index 2fb7d0f6..cfa1915c 100644
--- a/LICENSE-text.html
+++ b/LICENSE-text.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/articles/AMR.html b/articles/AMR.html
index f22c6b58..a51d8b75 100644
--- a/articles/AMR.html
+++ b/articles/AMR.html
@@ -38,7 +38,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
@@ -178,7 +178,7 @@
Dr. Matthijs
Berends
- 15 February 2023
+ 17 February 2023
Source: vignettes/AMR.Rmd
AMR.Rmd
@@ -190,7 +190,7 @@ Berends
website update since they are based on randomly created values and the
page was written in R
Markdown . However, the methodology remains unchanged. This page was
-generated on 15 February 2023.
+generated on 17 February 2023.
Introduction
@@ -246,21 +246,21 @@ make the structure of your data generally look like this:
-2023-02-15
+2023-02-17
abcd
Escherichia coli
S
S
-2023-02-15
+2023-02-17
abcd
Escherichia coli
S
R
-2023-02-15
+2023-02-17
efgh
Escherichia coli
R
@@ -411,71 +411,71 @@ data set:
-2010-08-08
-Y8
-Hospital B
+2013-03-23
+C3
+Hospital D
Escherichia coli
+I
+I
R
I
-I
-S
-F
+M
-2011-03-02
-Q1
-Hospital D
-Staphylococcus aureus
-I
+2017-06-18
+M9
+Hospital B
+Streptococcus pneumoniae
S
-R
-R
-F
+S
+S
+I
+M
-2016-04-28
-S9
-Hospital D
-Escherichia coli
-R
-I
-S
-R
-F
-
-
-2014-08-07
-T10
+2013-10-07
+M10
Hospital D
Streptococcus pneumoniae
+I
R
-R
-S
-R
-F
-
-
-2014-04-21
-I3
-Hospital D
-Escherichia coli
-S
-R
-S
-R
+I
+I
M
-2012-08-08
-M4
-Hospital B
+2013-03-21
+C9
+Hospital A
Escherichia coli
-S
I
+R
I
I
M
+
+2014-12-29
+Q10
+Hospital A
+Staphylococcus aureus
+S
+I
+R
+S
+F
+
+
+2015-08-23
+W8
+Hospital A
+Escherichia coli
+R
+R
+I
+I
+F
+
Now, let’s start the cleaning and the analysis!
@@ -510,16 +510,16 @@ Longest: 1
1
M
-10,421
-52.11%
-10,421
-52.11%
+10,408
+52.04%
+10,408
+52.04%
2
F
-9,579
-47.90%
+9,592
+47.96%
20,000
100.00%
@@ -632,10 +632,10 @@ takes into account the antimicrobial susceptibility test results using
# Basing inclusion on all antimicrobial results, using a points threshold of
# 2
# Including isolates from ICU.
-
# => Found 12,198 'phenotype-based' first isolates (61.0% of total where a
+
# => Found 12,380 'phenotype-based' first isolates (61.9% of total where a
# microbial ID was available)
-So only 61% is suitable for resistance analysis! We can now filter on
-it with the filter()
function, also from the
+
So only 61.9% is suitable for resistance analysis! We can now filter
+on it with the filter()
function, also from the
dplyr
package:
-So we end up with 12 198 isolates for analysis. Now our data looks
+
So we end up with 12 380 isolates for analysis. Now our data looks
like:
@@ -684,15 +684,15 @@ like:
1
-2010-08-08
-Y8
-Hospital B
+2013-03-23
+C3
+Hospital D
B_ESCHR_COLI
+I
+I
R
I
-I
-S
-F
+M
Gram-negative
Escherichia
coli
@@ -700,14 +700,46 @@ like:
2
-2011-03-02
-Q1
-Hospital D
-B_STPHY_AURS
-I
+2017-06-18
+M9
+Hospital B
+B_STRPT_PNMN
+S
+S
S
R
+M
+Gram-positive
+Streptococcus
+pneumoniae
+TRUE
+
+
+4
+2013-03-21
+C9
+Hospital A
+B_ESCHR_COLI
R
+R
+I
+I
+M
+Gram-negative
+Escherichia
+coli
+TRUE
+
+
+5
+2014-12-29
+Q10
+Hospital A
+B_STPHY_AURS
+S
+S
+R
+S
F
Gram-positive
Staphylococcus
@@ -715,47 +747,15 @@ like:
TRUE
-4
-2014-08-07
-T10
-Hospital D
-B_STRPT_PNMN
-R
-R
-S
-R
-F
-Gram-positive
-Streptococcus
-pneumoniae
-TRUE
-
-
6
-2012-08-08
-M4
-Hospital B
-B_ESCHR_COLI
-S
-S
-I
-I
-M
-Gram-negative
-Escherichia
-coli
-TRUE
-
-
-7
-2017-02-12
-O7
-Hospital B
+2015-08-23
+W8
+Hospital A
B_ESCHR_COLI
R
R
-R
-S
+I
+I
F
Gram-negative
Escherichia
@@ -763,19 +763,19 @@ like:
TRUE
-8
-2011-02-09
-K4
-Hospital A
-B_STRPT_PNMN
-I
-I
-S
+7
+2014-08-05
+R2
+Hospital D
+B_STPHY_AURS
R
-M
+I
+R
+R
+F
Gram-positive
-Streptococcus
-pneumoniae
+Staphylococcus
+aureus
TRUE
@@ -811,8 +811,8 @@ readable:
data_1st %>% freq ( genus , species )
Frequency table
Class: character
-Length: 12,198
-Available: 12,198 (100%, NA: 0 = 0%)
+Length: 12,380
+Available: 12,380 (100%, NA: 0 = 0%)
Unique: 4
Shortest: 16
Longest: 24
@@ -837,33 +837,33 @@ Longest: 24
1
Escherichia coli
-5,861
-48.05%
-5,861
-48.05%
+5,922
+47.84%
+5,922
+47.84%
2
Staphylococcus aureus
-3,183
-26.09%
-9,044
-74.14%
+3,262
+26.35%
+9,184
+74.18%
3
Streptococcus pneumoniae
-1,850
-15.17%
-10,894
-89.31%
+1,854
+14.98%
+11,038
+89.16%
4
Klebsiella pneumoniae
-1,304
-10.69%
-12,198
+1,342
+10.84%
+12,380
100.00%
@@ -912,42 +912,12 @@ antibiotic class they are in:
-2011-03-02
-Q1
-Hospital D
-B_STPHY_AURS
-I
-S
-R
-R
-F
-Gram-positive
-Staphylococcus
-aureus
-TRUE
-
-
-2014-08-07
-T10
-Hospital D
+2017-06-18
+M9
+Hospital B
B_STRPT_PNMN
-R
-R
S
-R
-F
-Gram-positive
-Streptococcus
-pneumoniae
-TRUE
-
-
-2011-02-09
-K4
-Hospital A
-B_STRPT_PNMN
-I
-I
+S
S
R
M
@@ -957,23 +927,23 @@ antibiotic class they are in:
TRUE
-2016-05-14
-P6
-Hospital C
-B_KLBSL_PNMN
-R
+2014-08-05
+R2
+Hospital D
+B_STPHY_AURS
R
+I
R
R
F
-Gram-negative
-Klebsiella
-pneumoniae
+Gram-positive
+Staphylococcus
+aureus
TRUE
-2010-02-23
-W6
+2011-08-22
+S8
Hospital A
B_ESCHR_COLI
R
@@ -987,15 +957,45 @@ antibiotic class they are in:
TRUE
-2014-05-10
-R2
+2013-07-23
+C7
Hospital A
+B_KLBSL_PNMN
+R
+S
+R
+R
+M
+Gram-negative
+Klebsiella
+pneumoniae
+TRUE
+
+
+2012-03-19
+H6
+Hospital A
+B_STPHY_AURS
+R
+R
+I
+R
+M
+Gram-positive
+Staphylococcus
+aureus
+TRUE
+
+
+2010-03-15
+A3
+Hospital B
B_ESCHR_COLI
R
R
S
R
-F
+M
Gram-negative
Escherichia
coli
@@ -1025,46 +1025,46 @@ different bug/drug combinations, you can use the
2
E. coli
AMC
-2766
-1144
-1951
-5861
+2776
+1183
+1963
+5922
1
E. coli
AMX
-1499
-1230
-3132
-5861
+1534
+1264
+3124
+5922
3
E. coli
CIP
-2070
-1784
-2007
-5861
+2035
+1845
+2042
+5922
4
E. coli
GEN
-2005
-1804
-2052
-5861
+2048
+1829
+2045
+5922
6
K. pneumoniae
AMC
-573
+595
281
-450
-1304
+466
+1342
5
@@ -1072,8 +1072,8 @@ different bug/drug combinations, you can use the
AMX
0
0
-1304
-1304
+1342
+1342
@@ -1095,34 +1095,34 @@ different bug/drug combinations, you can use the
E. coli
GEN
-2005
-1804
-2052
-5861
+2048
+1829
+2045
+5922
K. pneumoniae
GEN
-411
-441
-452
-1304
+472
+436
+434
+1342
S. aureus
GEN
-1092
-1014
-1077
-3183
+1107
+1029
+1126
+3262
S. pneumoniae
GEN
0
0
-1850
-1850
+1854
+1854
@@ -1154,7 +1154,7 @@ I (proportion_SI()
, equa
own:
+# [1] 0.5808562
Or can be used in conjunction with group_by()
and
summarise()
, both from the dplyr
package:
@@ -1169,19 +1169,19 @@ own:
Hospital A
-0.5925926
+0.5816024
Hospital B
-0.5784499
+0.5940042
Hospital C
-0.5731311
+0.5499199
Hospital D
-0.5802005
+0.5802964
@@ -1206,23 +1206,23 @@ all isolates available for every group (i.e. values S, I or R):
Hospital A
-0.5925926
-3726
+0.5816024
+3707
Hospital B
-0.5784499
-4232
+0.5940042
+4303
Hospital C
-0.5731311
-1846
+0.5499199
+1873
Hospital D
-0.5802005
-2394
+0.5802964
+2497
@@ -1247,27 +1247,27 @@ therapies very easily:
Escherichia
-0.6671217
-0.6498891
-0.8846613
+0.6685241
+0.6546775
+0.8850051
Klebsiella
-0.6549080
-0.6533742
-0.8788344
+0.6527571
+0.6766021
+0.8971684
Staphylococcus
-0.6830035
-0.6616400
-0.8850141
+0.6686082
+0.6548130
+0.8868792
Streptococcus
-0.4837838
+0.4778857
0.0000000
-0.4837838
+0.4778857
@@ -1295,23 +1295,23 @@ classes, use a antibiotic class selector such as
Hospital A
-59.3%
-36.3%
+58.2%
+35.3%
Hospital B
-57.8%
-35.5%
+59.4%
+37.5%
Hospital C
-57.3%
-35.6%
+55.0%
+34.5%
Hospital D
58.0%
-35.6%
+36.5%
@@ -1427,18 +1427,16 @@ classes) <mic>
and <disk>
:
mic_values <- random_mic ( size = 100 )
mic_values
# Class 'mic'
-# [1] 0.01 >=256 0.5 64 64 >=256 0.005 1 >=256
-# [10] 16 4 32 1 2 64 0.0625 0.0625 8
-# [19] 64 2 0.01 8 1 0.002 0.5 0.5 0.002
-# [28] 0.0625 0.005 32 2 0.01 1 4 64 8
-# [37] 0.125 32 0.125 0.002 >=256 0.005 0.002 2 8
-# [46] >=256 >=256 0.01 32 0.002 64 0.5 8 2
-# [55] 0.25 4 0.002 0.002 0.125 8 0.25 <=0.001 32
-# [64] <=0.001 <=0.001 0.002 >=256 0.002 0.5 0.125 0.01 <=0.001
-# [73] 2 8 0.01 0.25 128 0.025 128 0.25 0.005
-# [82] 0.01 0.002 32 32 1 0.5 >=256 2 0.025
-# [91] 4 8 4 0.25 0.5 0.5 1 0.01 32
-# [100] 0.5
+# [1] 32 64 0.002 2 16 8 128 0.025 0.0625 0.001
+# [11] 0.0625 0.005 16 128 4 0.025 0.01 128 0.001 16
+# [21] 128 0.025 4 0.002 0.01 64 4 0.125 >=256 128
+# [31] 1 0.002 0.005 64 0.25 0.025 16 32 32 1
+# [41] 8 2 32 16 0.0625 16 8 >=256 >=256 0.25
+# [51] 64 0.25 128 16 0.0625 0.001 4 0.0625 0.005 0.5
+# [61] 64 0.0625 0.025 0.001 0.001 0.005 0.0625 0.025 0.25 1
+# [71] 0.125 0.002 8 0.125 0.001 0.001 0.01 16 8 32
+# [81] 0.002 0.01 1 0.01 1 0.0625 0.025 0.01 1 1
+# [91] 0.025 0.125 8 4 32 >=256 4 0.001 4 0.005
# base R:
plot ( mic_values )
@@ -1472,10 +1470,10 @@ plotting:
disk_values <- random_disk ( size = 100 , mo = "E. coli" , ab = "cipro" )
disk_values
# Class 'disk'
-# [1] 24 28 29 21 30 30 22 20 23 25 31 28 24 20 25 18 17 21 28 24 19 31 28 25 17
-# [26] 30 31 25 26 18 29 27 29 24 23 31 18 22 22 31 20 24 27 18 18 29 27 30 25 27
-# [51] 17 29 20 26 24 18 26 28 22 30 29 20 26 28 30 24 19 19 26 17 22 22 17 30 24
-# [76] 17 27 20 23 23 18 30 27 21 24 19 25 23 24 20 18 30 20 23 22 25 18 30 28 21
+# [1] 26 25 22 31 23 25 21 17 28 29 23 26 21 19 29 21 25 27 25 28 28 30 23 26 17
+# [26] 29 27 25 28 21 26 28 24 27 31 22 21 23 18 29 26 30 30 28 18 25 20 30 29 17
+# [51] 18 21 27 24 29 21 24 22 26 27 18 25 28 31 19 18 18 28 19 22 18 27 28 31 21
+# [76] 31 18 17 27 20 26 24 17 26 23 19 20 18 25 26 26 24 24 29 30 19 19 23 31 25
# base R:
plot ( disk_values , mo = "E. coli" , ab = "cipro" )
diff --git a/articles/AMR_files/figure-html/disk_plots-1.png b/articles/AMR_files/figure-html/disk_plots-1.png
index f41e6100..02566ac7 100644
Binary files a/articles/AMR_files/figure-html/disk_plots-1.png and b/articles/AMR_files/figure-html/disk_plots-1.png differ
diff --git a/articles/AMR_files/figure-html/disk_plots_mo_ab-1.png b/articles/AMR_files/figure-html/disk_plots_mo_ab-1.png
index 55aa109c..3c0799d6 100644
Binary files a/articles/AMR_files/figure-html/disk_plots_mo_ab-1.png and b/articles/AMR_files/figure-html/disk_plots_mo_ab-1.png differ
diff --git a/articles/AMR_files/figure-html/mic_plots-1.png b/articles/AMR_files/figure-html/mic_plots-1.png
index 0f5327e8..fae351b4 100644
Binary files a/articles/AMR_files/figure-html/mic_plots-1.png and b/articles/AMR_files/figure-html/mic_plots-1.png differ
diff --git a/articles/AMR_files/figure-html/mic_plots-2.png b/articles/AMR_files/figure-html/mic_plots-2.png
index be0ddf73..85526788 100644
Binary files a/articles/AMR_files/figure-html/mic_plots-2.png and b/articles/AMR_files/figure-html/mic_plots-2.png differ
diff --git a/articles/AMR_files/figure-html/mic_plots_mo_ab-1.png b/articles/AMR_files/figure-html/mic_plots_mo_ab-1.png
index 91e80504..ec47566b 100644
Binary files a/articles/AMR_files/figure-html/mic_plots_mo_ab-1.png and b/articles/AMR_files/figure-html/mic_plots_mo_ab-1.png differ
diff --git a/articles/AMR_files/figure-html/mic_plots_mo_ab-2.png b/articles/AMR_files/figure-html/mic_plots_mo_ab-2.png
index fc29c73a..13fcf164 100644
Binary files a/articles/AMR_files/figure-html/mic_plots_mo_ab-2.png and b/articles/AMR_files/figure-html/mic_plots_mo_ab-2.png differ
diff --git a/articles/AMR_files/figure-html/plot 1-1.png b/articles/AMR_files/figure-html/plot 1-1.png
index 22ff92a5..cf4c3dd5 100644
Binary files a/articles/AMR_files/figure-html/plot 1-1.png and b/articles/AMR_files/figure-html/plot 1-1.png differ
diff --git a/articles/AMR_files/figure-html/plot 3-1.png b/articles/AMR_files/figure-html/plot 3-1.png
index f8bc62ff..f2867d5b 100644
Binary files a/articles/AMR_files/figure-html/plot 3-1.png and b/articles/AMR_files/figure-html/plot 3-1.png differ
diff --git a/articles/AMR_files/figure-html/plot 4-1.png b/articles/AMR_files/figure-html/plot 4-1.png
index c151f293..e2d45a67 100644
Binary files a/articles/AMR_files/figure-html/plot 4-1.png and b/articles/AMR_files/figure-html/plot 4-1.png differ
diff --git a/articles/AMR_files/figure-html/plot 5-1.png b/articles/AMR_files/figure-html/plot 5-1.png
index 9690c1e7..bf2fec46 100644
Binary files a/articles/AMR_files/figure-html/plot 5-1.png and b/articles/AMR_files/figure-html/plot 5-1.png differ
diff --git a/articles/EUCAST.html b/articles/EUCAST.html
index ef45b7ba..b82485d2 100644
--- a/articles/EUCAST.html
+++ b/articles/EUCAST.html
@@ -38,7 +38,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/articles/MDR.html b/articles/MDR.html
index 37d9530b..79e40f9b 100644
--- a/articles/MDR.html
+++ b/articles/MDR.html
@@ -38,7 +38,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
@@ -385,19 +385,19 @@ names or codes, this would have worked exactly the same way:
head ( my_TB_data )
# rifampicin isoniazid gatifloxacin ethambutol pyrazinamide moxifloxacin
-# 1 R R R I S I
-# 2 S I R S I I
-# 3 R S R I R R
-# 4 I I I I R R
-# 5 I R I R S R
-# 6 S R S I I I
+# 1 I S I I R R
+# 2 S I R S S R
+# 3 I I I R R S
+# 4 R R I R R I
+# 5 S R S R I I
+# 6 S S I R I I
# kanamycin
-# 1 S
-# 2 R
-# 3 S
+# 1 I
+# 2 S
+# 3 I
# 4 I
# 5 S
-# 6 S
+# 6 R
We can now add the interpretation of MDR-TB to our data set. You can
use:
@@ -438,40 +438,40 @@ Unique: 5
1
Mono-resistant
-3198
-63.96%
-3198
-63.96%
+3173
+63.46%
+3173
+63.46%
2
Negative
-997
-19.94%
-4195
-83.90%
+1003
+20.06%
+4176
+83.52%
3
Multi-drug-resistant
-438
-8.76%
-4633
-92.66%
+462
+9.24%
+4638
+92.76%
4
Poly-resistant
-257
-5.14%
-4890
-97.80%
+255
+5.10%
+4893
+97.86%
5
Extensively drug-resistant
-110
-2.20%
+107
+2.14%
5000
100.00%
diff --git a/articles/PCA.html b/articles/PCA.html
index 09545be4..e95dc9b7 100644
--- a/articles/PCA.html
+++ b/articles/PCA.html
@@ -38,7 +38,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/articles/SPSS.html b/articles/SPSS.html
index 49bf8048..21b9d376 100644
--- a/articles/SPSS.html
+++ b/articles/SPSS.html
@@ -38,7 +38,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
@@ -178,7 +178,7 @@
Dr. Matthijs
Berends
- 15 February 2023
+ 17 February 2023
Source: vignettes/SPSS.Rmd
SPSS.Rmd
diff --git a/articles/WHONET.html b/articles/WHONET.html
index aebf7d9f..ed1c140d 100644
--- a/articles/WHONET.html
+++ b/articles/WHONET.html
@@ -38,7 +38,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/articles/datasets.html b/articles/datasets.html
index be746582..0311af8a 100644
--- a/articles/datasets.html
+++ b/articles/datasets.html
@@ -38,7 +38,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
@@ -176,7 +176,7 @@
@@ -236,7 +236,7 @@
...
-
method extensions
+
when used in print()
: arguments passed on to knitr::kable()
(otherwise, has no use)
object
@@ -246,6 +246,10 @@
as_kable
a logical to indicate whether the printing should be done using knitr::kable()
(which is the default in non-interactive sessions)
+
+
italicise
+
a logical to indicate whether the microorganism names in the output table should be made italic, using italicise_taxonomy()
. This only works when the output format is markdown, such as in HTML output.
+
Details
@@ -484,6 +488,25 @@
#> 3 WISCA Group 1 Gram-positive (123-406) 76 89 81 95
#> 4 WISCA Group 2 Gram-positive (222-732) 76 89 88 95
+
# Print the output for R Markdown / Quarto -----------------------------
+
+
ureido <- antibiogram ( example_isolates ,
+
antibiotics = ureidopenicillins ( ) ,
+
ab_transform = "name" )
+
#> ℹ For ureidopenicillins() using column 'TZP' (piperacillin/tazobactam)
+
#> ℹ 86 combinations had less than minimum = 30 results and were ignored
+
+
# in an Rmd file, you would just need print(ureido), but to be explicit:
+
print ( ureido , as_kable = TRUE , format = "markdown" , italicise = TRUE )
+
#>
+
#>
+
#> | Pathogen (N min-max) | Piperacillin/tazobactam|
+
#> |:--------------------------|-----------------------:|
+
#> | CoNS (33-33) | 30|
+
#> | *E. coli* (416-416) | 94|
+
#> | *K. pneumoniae* (53-53) | 89|
+
#> | *S. pneumoniae* (112-112) | 100|
+
# Generate plots with ggplot2 or base R --------------------------------
@@ -499,21 +522,20 @@
)
#> ℹ 16 combinations had less than minimum = 30 results and were ignored
-
plot ( ab1 )
-
-
if ( requireNamespace ( "ggplot2" ) ) {
ggplot2 :: autoplot ( ab1 )
}
-
-
-
plot ( ab2 )
-
-
+
if ( requireNamespace ( "ggplot2" ) ) {
ggplot2 :: autoplot ( ab2 )
}
+
+
+
plot ( ab1 )
+
+
plot ( ab2 )
+
# }
diff --git a/reference/antibiotic_class_selectors.html b/reference/antibiotic_class_selectors.html
index 1636a1f6..6630eedc 100644
--- a/reference/antibiotic_class_selectors.html
+++ b/reference/antibiotic_class_selectors.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/antibiotics.html b/reference/antibiotics.html
index 46f9e34a..5fb63db5 100644
--- a/reference/antibiotics.html
+++ b/reference/antibiotics.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/as.ab.html b/reference/as.ab.html
index d3bce746..458467d8 100644
--- a/reference/as.ab.html
+++ b/reference/as.ab.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/as.av.html b/reference/as.av.html
index 9a6bac91..bbf1b896 100644
--- a/reference/as.av.html
+++ b/reference/as.av.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/as.disk.html b/reference/as.disk.html
index b6075639..61598a16 100644
--- a/reference/as.disk.html
+++ b/reference/as.disk.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/as.mic.html b/reference/as.mic.html
index 3c30b4b4..6d4c402c 100644
--- a/reference/as.mic.html
+++ b/reference/as.mic.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/as.mo.html b/reference/as.mo.html
index 3905f759..ffee1c81 100644
--- a/reference/as.mo.html
+++ b/reference/as.mo.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/as.sir.html b/reference/as.sir.html
index 51cdeb38..3f66f26a 100644
--- a/reference/as.sir.html
+++ b/reference/as.sir.html
@@ -12,7 +12,7 @@ All breakpoints used for interpretation are publicly available in the clinical_b
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
@@ -534,16 +534,16 @@ A microorganism is categorised as "Resistant" when there is a high likelihood of
#> # A tibble: 50 × 17
#> datetime index ab_input ab_guid…¹ mo_in…² mo_guideline guide…³
#> <dttm> <int> <chr> <ab> <chr> <mo> <chr>
-#> 1 2023-02-15 18:53:27 1 TOB TOB Escher… B_[ORD]_ENTRBCTR EUCAST…
-#> 2 2023-02-15 18:53:27 1 GEN GEN Escher… B_[ORD]_ENTRBCTR EUCAST…
-#> 3 2023-02-15 18:53:27 1 CIP CIP Escher… B_[ORD]_ENTRBCTR EUCAST…
-#> 4 2023-02-15 18:53:26 1 AMP AMP Escher… B_[ORD]_ENTRBCTR EUCAST…
-#> 5 2023-02-15 18:53:22 1 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
-#> 6 2023-02-15 18:53:22 2 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
-#> 7 2023-02-15 18:53:22 3 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
-#> 8 2023-02-15 18:53:22 4 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
-#> 9 2023-02-15 18:53:22 5 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
-#> 10 2023-02-15 18:53:22 6 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
+#> 1 2023-02-17 08:51:10 1 TOB TOB Escher… B_[ORD]_ENTRBCTR EUCAST…
+#> 2 2023-02-17 08:51:10 1 GEN GEN Escher… B_[ORD]_ENTRBCTR EUCAST…
+#> 3 2023-02-17 08:51:09 1 CIP CIP Escher… B_[ORD]_ENTRBCTR EUCAST…
+#> 4 2023-02-17 08:51:09 1 AMP AMP Escher… B_[ORD]_ENTRBCTR EUCAST…
+#> 5 2023-02-17 08:51:03 1 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
+#> 6 2023-02-17 08:51:03 2 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
+#> 7 2023-02-17 08:51:03 3 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
+#> 8 2023-02-17 08:51:03 4 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
+#> 9 2023-02-17 08:51:03 5 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
+#> 10 2023-02-17 08:51:03 6 CIP CIP B_ESCH… B_[ORD]_ENTRBCTR EUCAST…
#> # … with 40 more rows, 10 more variables: ref_table <chr>, method <chr>,
#> # input <dbl>, outcome <sir>, breakpoint_S_R <chr>, ab_considered <lgl>,
#> # mo_considered <lgl>, breakpoint_S <lgl>, breakpoint_R <lgl>,
diff --git a/reference/atc_online.html b/reference/atc_online.html
index cc33d9ac..e47d0fcf 100644
--- a/reference/atc_online.html
+++ b/reference/atc_online.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/av_from_text.html b/reference/av_from_text.html
index fdb33d12..62c27ec9 100644
--- a/reference/av_from_text.html
+++ b/reference/av_from_text.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/av_property.html b/reference/av_property.html
index e0032f86..b8332071 100644
--- a/reference/av_property.html
+++ b/reference/av_property.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/availability.html b/reference/availability.html
index 2433179b..740e2497 100644
--- a/reference/availability.html
+++ b/reference/availability.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/bug_drug_combinations.html b/reference/bug_drug_combinations.html
index 7830051c..39ef5952 100644
--- a/reference/bug_drug_combinations.html
+++ b/reference/bug_drug_combinations.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/clinical_breakpoints.html b/reference/clinical_breakpoints.html
index c3deb203..7d801501 100644
--- a/reference/clinical_breakpoints.html
+++ b/reference/clinical_breakpoints.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/count.html b/reference/count.html
index cd7ffd73..150c6095 100644
--- a/reference/count.html
+++ b/reference/count.html
@@ -12,7 +12,7 @@ count_resistant() should be used to count resistant isolates, count_susceptible(
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/custom_eucast_rules.html b/reference/custom_eucast_rules.html
index b98fdc6e..e496202f 100644
--- a/reference/custom_eucast_rules.html
+++ b/reference/custom_eucast_rules.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/dosage.html b/reference/dosage.html
index 3cf9ea3f..a2aebb34 100644
--- a/reference/dosage.html
+++ b/reference/dosage.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/eucast_rules.html b/reference/eucast_rules.html
index bede40aa..077f50d7 100644
--- a/reference/eucast_rules.html
+++ b/reference/eucast_rules.html
@@ -12,7 +12,7 @@ To improve the interpretation of the antibiogram before EUCAST rules are applied
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/example_isolates.html b/reference/example_isolates.html
index 13e2ce29..fb1f5a2a 100644
--- a/reference/example_isolates.html
+++ b/reference/example_isolates.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/example_isolates_unclean.html b/reference/example_isolates_unclean.html
index 83647687..2e518915 100644
--- a/reference/example_isolates_unclean.html
+++ b/reference/example_isolates_unclean.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/first_isolate.html b/reference/first_isolate.html
index 00857b8c..854119f2 100644
--- a/reference/first_isolate.html
+++ b/reference/first_isolate.html
@@ -12,7 +12,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/g.test.html b/reference/g.test.html
index 79008591..f39ceae4 100644
--- a/reference/g.test.html
+++ b/reference/g.test.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/get_episode.html b/reference/get_episode.html
index 5fc92794..faa65d3f 100644
--- a/reference/get_episode.html
+++ b/reference/get_episode.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
@@ -192,29 +192,27 @@
df <- example_isolates [ sample ( seq_len ( 2000 ) , size = 100 ) , ]
get_episode ( df $ date , episode_days = 60 ) # indices
-#> [1] 36 31 10 45 37 31 22 44 49 1 15 11 16 26 19 18 9 45 47 35 6 2 3 44 8
-#> [26] 13 2 40 10 1 19 14 32 3 46 22 48 44 47 7 34 34 48 39 27 12 29 17 1 6
-#> [51] 12 33 35 49 37 39 44 3 30 49 38 37 39 43 6 29 6 5 7 20 22 46 14 6 48
-#> [76] 6 43 34 45 1 20 10 50 4 15 4 31 20 42 25 24 41 5 7 34 28 47 23 15 21
+#> [1] 35 16 14 38 5 7 10 13 8 26 33 1 21 23 50 43 19 21 21 18 10 31 42 49 7
+#> [26] 18 14 9 45 24 21 47 40 44 48 35 27 31 12 21 15 28 37 10 25 35 44 18 29 46
+#> [51] 18 42 18 30 17 31 45 3 20 43 25 40 38 47 10 10 22 34 19 36 13 11 41 49 12
+#> [76] 12 39 32 15 35 22 7 44 26 4 50 51 16 42 26 6 35 10 14 2 38 14 27 41 38
is_new_episode ( df $ date , episode_days = 60 ) # TRUE/FALSE
-#> [1] TRUE TRUE TRUE TRUE TRUE FALSE TRUE TRUE TRUE TRUE TRUE TRUE
-#> [13] TRUE TRUE TRUE TRUE TRUE FALSE TRUE TRUE TRUE TRUE TRUE FALSE
-#> [25] TRUE TRUE FALSE TRUE FALSE FALSE FALSE TRUE TRUE FALSE TRUE FALSE
-#> [37] TRUE FALSE FALSE TRUE TRUE FALSE FALSE TRUE TRUE TRUE TRUE TRUE
-#> [49] FALSE FALSE FALSE TRUE FALSE FALSE FALSE FALSE FALSE FALSE TRUE FALSE
-#> [61] TRUE FALSE FALSE TRUE FALSE FALSE FALSE TRUE FALSE TRUE FALSE FALSE
-#> [73] FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE TRUE TRUE
-#> [85] FALSE FALSE FALSE FALSE TRUE TRUE TRUE TRUE FALSE FALSE FALSE TRUE
-#> [97] FALSE TRUE FALSE TRUE
+#> [1] TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE
+#> [13] TRUE TRUE TRUE TRUE TRUE FALSE FALSE TRUE FALSE TRUE TRUE TRUE
+#> [25] FALSE FALSE FALSE TRUE TRUE TRUE FALSE TRUE TRUE TRUE TRUE FALSE
+#> [37] TRUE FALSE TRUE FALSE TRUE TRUE TRUE FALSE TRUE FALSE FALSE FALSE
+#> [49] TRUE TRUE FALSE FALSE FALSE TRUE TRUE FALSE FALSE TRUE TRUE FALSE
+#> [61] FALSE FALSE FALSE FALSE FALSE FALSE TRUE TRUE FALSE TRUE FALSE TRUE
+#> [73] TRUE FALSE FALSE FALSE TRUE TRUE FALSE FALSE FALSE FALSE FALSE FALSE
+#> [85] TRUE FALSE TRUE FALSE FALSE FALSE TRUE FALSE FALSE FALSE TRUE FALSE
+#> [97] FALSE FALSE FALSE FALSE
# filter on results from the third 60-day episode only, using base R
df [ which ( get_episode ( df $ date , 60 ) == 3 ) , ]
-#> # A tibble: 3 × 46
-#> date patient age gender ward mo PEN OXA FLC AMX
-#> <date> <chr> <dbl> <chr> <chr> <mo> <sir> <sir> <sir> <sir>
-#> 1 2002-11-11 D80753 74 F Outpatie… B_STPHY_CONS R NA S NA
-#> 2 2002-11-18 956065 89 F Clinical B_ESCHR_COLI R NA NA NA
-#> 3 2002-11-16 762305 87 F Clinical B_PROTS_MRBL R NA NA NA
+#> # A tibble: 1 × 46
+#> date patient age gender ward mo PEN OXA FLC AMX
+#> <date> <chr> <dbl> <chr> <chr> <mo> <sir> <sir> <sir> <sir>
+#> 1 2002-07-23 F35553 51 M ICU B_STPHY_AURS R NA S R
#> # … with 36 more variables: AMC <sir>, AMP <sir>, TZP <sir>, CZO <sir>,
#> # FEP <sir>, CXM <sir>, FOX <sir>, CTX <sir>, CAZ <sir>, CRO <sir>,
#> # GEN <sir>, TOB <sir>, AMK <sir>, KAN <sir>, TMP <sir>, SXT <sir>,
@@ -249,19 +247,19 @@
arrange ( patient , condition , date )
}
#> # A tibble: 100 × 4
-#> # Groups: patient, condition [97]
+#> # Groups: patient, condition [96]
#> patient date condition new_episode
#> <chr> <date> <chr> <lgl>
-#> 1 022060 2004-05-04 A TRUE
-#> 2 022060 2004-05-04 C TRUE
-#> 3 067927 2002-01-29 C TRUE
-#> 4 071099 2005-01-11 C TRUE
-#> 5 0F9638 2014-09-22 B TRUE
-#> 6 174209 2011-10-03 A TRUE
-#> 7 183220 2008-11-14 A TRUE
-#> 8 189363 2004-03-16 A TRUE
-#> 9 218912 2007-02-24 A TRUE
-#> 10 218912 2002-07-30 B TRUE
+#> 1 008268 2007-02-20 B TRUE
+#> 2 067927 2002-01-07 C TRUE
+#> 3 0E2483 2007-04-06 A TRUE
+#> 4 0F9638 2014-09-22 A TRUE
+#> 5 124128 2006-10-02 C TRUE
+#> 6 1435C8 2004-03-03 C TRUE
+#> 7 151041 2006-02-10 C TRUE
+#> 8 16DC39 2015-11-19 A TRUE
+#> 9 180928 2008-06-14 A TRUE
+#> 10 22B987 2009-10-19 C TRUE
#> # … with 90 more rows
if ( require ( "dplyr" ) ) {
@@ -275,19 +273,19 @@
arrange ( patient , ward , date )
}
#> # A tibble: 100 × 5
-#> # Groups: ward, patient [94]
-#> ward date patient new_index new_logical
-#> <chr> <date> <chr> <int> <lgl>
-#> 1 ICU 2004-05-04 022060 1 TRUE
-#> 2 ICU 2004-05-04 022060 1 FALSE
-#> 3 ICU 2002-01-29 067927 1 TRUE
-#> 4 Clinical 2005-01-11 071099 1 TRUE
-#> 5 Clinical 2014-09-22 0F9638 1 TRUE
-#> 6 Outpatient 2011-10-03 174209 1 TRUE
-#> 7 Clinical 2008-11-14 183220 1 TRUE
-#> 8 Clinical 2004-03-16 189363 1 TRUE
-#> 9 ICU 2002-07-30 218912 1 TRUE
-#> 10 ICU 2007-02-24 218912 2 TRUE
+#> # Groups: ward, patient [91]
+#> ward date patient new_index new_logical
+#> <chr> <date> <chr> <int> <lgl>
+#> 1 ICU 2007-02-20 008268 1 TRUE
+#> 2 ICU 2002-01-07 067927 1 TRUE
+#> 3 Clinical 2007-04-06 0E2483 1 TRUE
+#> 4 Clinical 2014-09-22 0F9638 1 TRUE
+#> 5 Clinical 2006-10-02 124128 1 TRUE
+#> 6 Clinical 2004-03-03 1435C8 1 TRUE
+#> 7 Clinical 2006-02-10 151041 1 TRUE
+#> 8 ICU 2015-11-19 16DC39 1 TRUE
+#> 9 Clinical 2008-06-14 180928 1 TRUE
+#> 10 Clinical 2009-10-19 22B987 1 TRUE
#> # … with 90 more rows
if ( require ( "dplyr" ) ) {
@@ -303,9 +301,9 @@
#> # A tibble: 3 × 5
#> ward n_patients n_episodes_365 n_episodes_60 n_episodes_30
#> <chr> <int> <int> <int> <int>
-#> 1 Clinical 60 12 37 43
-#> 2 ICU 28 11 23 26
-#> 3 Outpatient 6 4 6 6
+#> 1 Clinical 67 13 40 48
+#> 2 ICU 20 12 20 21
+#> 3 Outpatient 4 4 4 4
# grouping on patients and microorganisms leads to the same
# results as first_isolate() when using 'episode-based':
@@ -334,19 +332,19 @@
select ( group_vars ( . ) , flag_episode )
}
#> # A tibble: 100 × 4
-#> # Groups: patient, mo, ward [98]
+#> # Groups: patient, mo, ward [94]
#> patient mo ward flag_episode
#> <chr> <mo> <chr> <lgl>
-#> 1 FC0C51 B_ESCHR_COLI Clinical TRUE
-#> 2 D58366 B_ENTRC_FCLS Clinical TRUE
-#> 3 E15167 B_ENTRC_FCLS Clinical TRUE
-#> 4 964129 B_SERRT_MRCS Clinical TRUE
-#> 5 0F9638 B_ESCHR_COLI Clinical TRUE
-#> 6 A66134 B_STPHY_AURS Clinical TRUE
-#> 7 183220 B_STPHY_CONS Clinical TRUE
-#> 8 960787 B_ENTRC_FACM Clinical TRUE
-#> 9 BF4515 B_ENTRC_FACM ICU TRUE
-#> 10 495616 B_STPHY_EPDR Clinical TRUE
+#> 1 8697C7 B_STPHY_CONS Clinical TRUE
+#> 2 F3F09F B_STRPT_ORLS Clinical TRUE
+#> 3 A90606 B_STRPT_PNMN Clinical TRUE
+#> 4 435623 B_CTRBC_FRND ICU TRUE
+#> 5 6BC362 B_CRYNB ICU TRUE
+#> 6 739C43 B_ESCHR_COLI Clinical TRUE
+#> 7 F58364 B_STRPT_MITS Clinical TRUE
+#> 8 969581 B_STPHY_CONS Clinical TRUE
+#> 9 8DB5B8 B_STPHY_CONS Clinical TRUE
+#> 10 882122 B_STRPT_GRPC Clinical TRUE
#> # … with 90 more rows
# }
diff --git a/reference/ggplot_pca.html b/reference/ggplot_pca.html
index 7c103bfb..b3029f58 100644
--- a/reference/ggplot_pca.html
+++ b/reference/ggplot_pca.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/ggplot_sir.html b/reference/ggplot_sir.html
index 286af251..64b5ffc7 100644
--- a/reference/ggplot_sir.html
+++ b/reference/ggplot_sir.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/guess_ab_col.html b/reference/guess_ab_col.html
index faebac44..24b8ee78 100644
--- a/reference/guess_ab_col.html
+++ b/reference/guess_ab_col.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/index.html b/reference/index.html
index 48cd68a7..454ef3b2 100644
--- a/reference/index.html
+++ b/reference/index.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/intrinsic_resistant.html b/reference/intrinsic_resistant.html
index 2466afe4..2de8d2c8 100644
--- a/reference/intrinsic_resistant.html
+++ b/reference/intrinsic_resistant.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/italicise_taxonomy.html b/reference/italicise_taxonomy.html
index ae9e187e..d9d005dd 100644
--- a/reference/italicise_taxonomy.html
+++ b/reference/italicise_taxonomy.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/join.html b/reference/join.html
index dd6b9688..946c2f4f 100644
--- a/reference/join.html
+++ b/reference/join.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/key_antimicrobials.html b/reference/key_antimicrobials.html
index 0b1470a0..15bf6868 100644
--- a/reference/key_antimicrobials.html
+++ b/reference/key_antimicrobials.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/kurtosis.html b/reference/kurtosis.html
index c3ae3dff..315ef1f1 100644
--- a/reference/kurtosis.html
+++ b/reference/kurtosis.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
@@ -182,9 +182,9 @@
Examples
kurtosis ( rnorm ( 10000 ) )
-#> [1] 3.02291
+#> [1] 2.999342
kurtosis ( rnorm ( 10000 ) , excess = TRUE )
-#> [1] -0.06230735
+#> [1] 0.009065911
On this page
diff --git a/reference/like.html b/reference/like.html
index 9dc63b44..b9efdc55 100644
--- a/reference/like.html
+++ b/reference/like.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/mdro.html b/reference/mdro.html
index abbb27f8..c20494b5 100644
--- a/reference/mdro.html
+++ b/reference/mdro.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/mean_amr_distance.html b/reference/mean_amr_distance.html
index 626706aa..78f1592c 100644
--- a/reference/mean_amr_distance.html
+++ b/reference/mean_amr_distance.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
@@ -201,30 +201,30 @@
sir <- random_sir ( 10 )
sir
#> Class 'sir'
-#> [1] R R I I I I R S S S
+#> [1] S R S R R R I I S S
mean_amr_distance ( sir )
-#> [1] 1.449138 1.449138 -0.621059 -0.621059 -0.621059 -0.621059 1.449138
-#> [8] -0.621059 -0.621059 -0.621059
+#> [1] -0.7745967 1.1618950 -0.7745967 1.1618950 1.1618950 1.1618950
+#> [7] -0.7745967 -0.7745967 -0.7745967 -0.7745967
mic <- random_mic ( 10 )
mic
#> Class 'mic'
-#> [1] >=128 32 0.25 2 0.5 0.002 0.025 64 8 64
+#> [1] 0.005 0.002 0.025 1 64 0.0625 0.025 0.001 16 0.25
mean_amr_distance ( mic )
-#> [1] 1.10682807 0.73345287 -0.57336033 -0.01329753 -0.38667273 -1.87378587
-#> [7] -1.19352311 0.92014047 0.36007767 0.92014047
+#> [1] -0.8096905 -1.0573468 -0.3746895 0.6223458 1.7464143 -0.1270332
+#> [7] -0.3746895 -1.2446916 1.3717248 0.2476563
# equal to the Z-score of their log2:
( log2 ( mic ) - mean ( log2 ( mic ) ) ) / sd ( log2 ( mic ) )
-#> [1] 1.10682807 0.73345287 -0.57336033 -0.01329753 -0.38667273 -1.87378587
-#> [7] -1.19352311 0.92014047 0.36007767 0.92014047
+#> [1] -0.8096905 -1.0573468 -0.3746895 0.6223458 1.7464143 -0.1270332
+#> [7] -0.3746895 -1.2446916 1.3717248 0.2476563
disk <- random_disk ( 10 )
disk
#> Class 'disk'
-#> [1] 40 43 7 33 17 6 43 34 8 46
+#> [1] 10 22 14 48 42 42 49 25 10 19
mean_amr_distance ( disk )
-#> [1] 0.7494646 0.9322608 -1.2612940 0.3229400 -0.6519732 -1.3222261
-#> [7] 0.9322608 0.3838721 -1.2003619 1.1150570
+#> [1] -1.1569176 -0.3899004 -0.9012452 1.2719702 0.8884616 0.8884616
+#> [7] 1.3358883 -0.1981461 -1.1569176 -0.5816547
y <- data.frame (
id = LETTERS [ 1 : 10 ] ,
@@ -234,22 +234,22 @@
tobr = random_mic ( 10 , ab = "tobr" , mo = "Escherichia coli" )
)
y
-#> id amox cipr gent tobr
-#> 1 A I 29 <=2 2
-#> 2 B R 21 >=8 2
-#> 3 C R 31 4 1
-#> 4 D S 19 4 1
-#> 5 E I 21 4 1
-#> 6 F R 31 <=2 4
-#> 7 G S 20 4 1
-#> 8 H R 25 4 2
-#> 9 I R 24 >=8 4
-#> 10 J S 20 >=8 2
+#> id amox cipr gent tobr
+#> 1 A R 26 0.5 4
+#> 2 B S 17 <=0.25 2
+#> 3 C R 27 1 1
+#> 4 D I 17 >=2 2
+#> 5 E I 20 0.5 <=0.5
+#> 6 F I 29 <=0.25 2
+#> 7 G R 20 0.5 4
+#> 8 H S 20 >=2 2
+#> 9 I R 27 0.5 <=0.5
+#> 10 J R 17 0.5 4
mean_amr_distance ( y )
#> ℹ Calculating mean AMR distance based on columns "amox", "cipr", "gent" and
#> "tobr"
-#> [1] -0.2859019 0.4406350 0.3166812 -0.7958139 -0.6894550 0.6117315
-#> [7] -0.7426344 0.3145374 0.9171062 -0.0868861
+#> [1] 0.64170105 -0.76377032 0.49004949 -0.05578894 -0.80988224 -0.13053253
+#> [7] 0.32508215 0.10252050 0.03384812 0.16677271
y $ amr_distance <- mean_amr_distance ( y , where ( is.mic ) )
#> Error in .subset(x, j): invalid subscript type 'list'
y [ order ( y $ amr_distance ) , ]
@@ -265,17 +265,17 @@
}
#> ℹ Calculating mean AMR distance based on columns "amox", "cipr", "gent" and
#> "tobr"
-#> id amox cipr gent tobr amr_distance check_id_C
-#> 1 C R 31 4 1 0.3166812 0.000000000
-#> 2 H R 25 4 2 0.3145374 0.002143877
-#> 3 B R 21 >=8 2 0.4406350 0.123953772
-#> 4 F R 31 <=2 4 0.6117315 0.295050227
-#> 5 J S 20 >=8 2 -0.0868861 0.403567331
-#> 6 I R 24 >=8 4 0.9171062 0.600424979
-#> 7 A I 29 <=2 2 -0.2859019 0.602583175
-#> 8 E I 21 4 1 -0.6894550 1.006136186
-#> 9 G S 20 4 1 -0.7426344 1.059315640
-#> 10 D S 19 4 1 -0.7958139 1.112495094
+#> id amox cipr gent tobr amr_distance check_id_C
+#> 1 C R 27 1 1 0.49004949 0.0000000
+#> 2 A R 26 0.5 4 0.64170105 0.1516516
+#> 3 G R 20 0.5 4 0.32508215 0.1649673
+#> 4 J R 17 0.5 4 0.16677271 0.3232768
+#> 5 H S 20 >=2 2 0.10252050 0.3875290
+#> 6 I R 27 0.5 <=0.5 0.03384812 0.4562014
+#> 7 D I 17 >=2 2 -0.05578894 0.5458384
+#> 8 F I 29 <=0.25 2 -0.13053253 0.6205820
+#> 9 B S 17 <=0.25 2 -0.76377032 1.2538198
+#> 10 E I 20 0.5 <=0.5 -0.80988224 1.2999317
if ( require ( "dplyr" ) ) {
# support for groups
example_isolates %>%
diff --git a/reference/microorganisms.codes.html b/reference/microorganisms.codes.html
index c53622eb..d6639ce2 100644
--- a/reference/microorganisms.codes.html
+++ b/reference/microorganisms.codes.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/microorganisms.html b/reference/microorganisms.html
index 5b747784..f99b2bd4 100644
--- a/reference/microorganisms.html
+++ b/reference/microorganisms.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/mo_matching_score.html b/reference/mo_matching_score.html
index cf7f8802..af4d0d82 100644
--- a/reference/mo_matching_score.html
+++ b/reference/mo_matching_score.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/mo_property.html b/reference/mo_property.html
index 5f617103..4c7b91cc 100644
--- a/reference/mo_property.html
+++ b/reference/mo_property.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/mo_source.html b/reference/mo_source.html
index 5bb86f88..c09e3607 100644
--- a/reference/mo_source.html
+++ b/reference/mo_source.html
@@ -12,7 +12,7 @@ This is the fastest way to have your organisation (or analysis) specific codes p
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/pca.html b/reference/pca.html
index 11b8fc84..e428f369 100644
--- a/reference/pca.html
+++ b/reference/pca.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/plot-1.png b/reference/plot-1.png
index 69fc411c..9c954d43 100644
Binary files a/reference/plot-1.png and b/reference/plot-1.png differ
diff --git a/reference/plot-2.png b/reference/plot-2.png
index 26e5ec7b..2ac1a1ce 100644
Binary files a/reference/plot-2.png and b/reference/plot-2.png differ
diff --git a/reference/plot-3.png b/reference/plot-3.png
index ad0f4820..1f2cb104 100644
Binary files a/reference/plot-3.png and b/reference/plot-3.png differ
diff --git a/reference/plot-4.png b/reference/plot-4.png
index f895c6e2..6f48d935 100644
Binary files a/reference/plot-4.png and b/reference/plot-4.png differ
diff --git a/reference/plot-5.png b/reference/plot-5.png
index 93370575..77d24e8a 100644
Binary files a/reference/plot-5.png and b/reference/plot-5.png differ
diff --git a/reference/plot-6.png b/reference/plot-6.png
index dc0a9a18..77423757 100644
Binary files a/reference/plot-6.png and b/reference/plot-6.png differ
diff --git a/reference/plot-7.png b/reference/plot-7.png
index 7ef14280..3ccdf351 100644
Binary files a/reference/plot-7.png and b/reference/plot-7.png differ
diff --git a/reference/plot-8.png b/reference/plot-8.png
index c2240f4b..51c613b1 100644
Binary files a/reference/plot-8.png and b/reference/plot-8.png differ
diff --git a/reference/plot-9.png b/reference/plot-9.png
index 18195e10..de6ca961 100644
Binary files a/reference/plot-9.png and b/reference/plot-9.png differ
diff --git a/reference/plot.html b/reference/plot.html
index 9f06651c..f1b15073 100644
--- a/reference/plot.html
+++ b/reference/plot.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/proportion.html b/reference/proportion.html
index 89b78749..b61dd738 100644
--- a/reference/proportion.html
+++ b/reference/proportion.html
@@ -12,7 +12,7 @@ resistance() should be used to calculate resistance, susceptibility() should be
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/random.html b/reference/random.html
index 70d57b94..186172be 100644
--- a/reference/random.html
+++ b/reference/random.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
@@ -193,43 +193,41 @@
Examples
random_mic ( 25 )
#> Class 'mic'
-#> [1] 32 0.01 0.005 0.5 0.025 >=256 0.0625 >=256 >=256
-#> [10] 0.25 64 <=0.002 0.025 0.125 128 0.01 0.25 0.25
-#> [19] 1 128 128 0.005 32 0.0625 2
+#> [1] 0.025 2 4 0.01 <=0.001 0.01 8 0.01 8
+#> [10] 4 16 64 0.01 0.005 0.25 0.125 0.25 8
+#> [19] 0.025 1 8 0.005 0.01 <=0.001 0.01
random_disk ( 25 )
#> Class 'disk'
-#> [1] 19 15 43 41 37 41 46 47 49 9 30 39 8 36 8 19 24 14 25 48 39 7 12 8 49
+#> [1] 11 40 41 23 18 8 43 47 14 7 13 50 15 45 42 46 44 47 47 44 42 11 22 49 42
random_sir ( 25 )
#> Class 'sir'
-#> [1] I S I R R R R R S R S S I R S S R S I S R S S R S
+#> [1] R S R I S R I I S I S I S I I R I S S R S S I R S
# \donttest{
# make the random generation more realistic by setting a bug and/or drug:
random_mic ( 25 , "Klebsiella pneumoniae" ) # range 0.0625-64
#> Class 'mic'
-#> [1] 0.001 8 1 0.01 0.025 8 64 0.5 0.01 0.002 32 16
-#> [13] 128 0.25 4 0.005 0.025 0.125 256 64 128 32 16 8
-#> [25] 64
+#> [1] 0.005 32 0.025 0.002 0.025 1 0.25 0.5 0.25 0.125
+#> [11] 32 16 0.0625 0.01 0.002 4 0.002 0.005 2 32
+#> [21] 2 0.01 0.025 0.5 64
random_mic ( 25 , "Klebsiella pneumoniae" , "meropenem" ) # range 0.0625-16
#> Class 'mic'
-#> [1] 2 1 0.25 2 32 8 32 16 >=64 0.25 >=64 0.5 2 >=64 16
-#> [16] 0.25 8 8 4 >=64 0.25 2 1 16 0.5
+#> [1] 8 1 8 1 4 16 2 1 4 2 16 1 4 1 1 1 16 4 8 1 2 1 8 4 16
random_mic ( 25 , "Streptococcus pneumoniae" , "meropenem" ) # range 0.0625-4
#> Class 'mic'
-#> [1] 8 1 <=0.0625 0.25 >=16 0.5 1 1
-#> [9] 8 0.5 >=16 1 8 0.5 0.25 4
-#> [17] <=0.0625 4 8 8 2 0.5 1 0.5
-#> [25] 2
+#> [1] 0.0625 1 0.125 0.125 <=0.025 <=0.025 0.0625 >=8 0.0625
+#> [10] 4 2 0.0625 1 >=8 0.125 2 0.25 4
+#> [19] 0.125 0.125 1 >=8 0.5 4 0.25
random_disk ( 25 , "Klebsiella pneumoniae" ) # range 8-50
#> Class 'disk'
-#> [1] 22 42 48 44 25 31 46 49 21 30 49 22 46 44 21 20 47 33 47 44 45 13 17 24 44
+#> [1] 43 36 15 45 10 35 19 20 36 49 43 22 38 49 45 47 23 28 27 27 41 50 41 48 13
random_disk ( 25 , "Klebsiella pneumoniae" , "ampicillin" ) # range 11-17
#> Class 'disk'
-#> [1] 16 17 17 15 16 11 13 11 11 14 14 14 15 15 13 15 17 12 12 17 15 16 17 14 13
+#> [1] 11 14 15 15 17 12 11 17 15 13 16 12 11 12 13 14 15 11 16 13 12 12 13 16 15
random_disk ( 25 , "Streptococcus pneumoniae" , "ampicillin" ) # range 12-27
#> Class 'disk'
-#> [1] 19 24 15 18 17 26 18 19 27 27 19 26 25 25 26 24 27 21 15 15 24 16 18 18 20
+#> [1] 26 24 20 19 16 23 16 17 25 26 15 23 18 18 19 26 18 15 16 25 24 27 23 16 23
# }
diff --git a/reference/resistance_predict.html b/reference/resistance_predict.html
index 8b0da4f3..43552f89 100644
--- a/reference/resistance_predict.html
+++ b/reference/resistance_predict.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/reference/skewness.html b/reference/skewness.html
index a1d96809..6b81967b 100644
--- a/reference/skewness.html
+++ b/reference/skewness.html
@@ -12,7 +12,7 @@ When negative ('left-skewed'): the left tail is longer; the mass of the distribu
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
@@ -181,7 +181,7 @@ When negative ('left-skewed'): the left tail is longer; the mass of the distribu
Examples
skewness ( runif ( 1000 ) )
-#> [1] 0.02219704
+#> [1] 0.02987134
On this page
diff --git a/reference/translate.html b/reference/translate.html
index c1ceb442..550d1053 100644
--- a/reference/translate.html
+++ b/reference/translate.html
@@ -10,7 +10,7 @@
AMR (for R)
- 1.8.2.9131
+ 1.8.2.9132
diff --git a/search.json b/search.json
index 958902bd..f1a74d38 100644
--- a/search.json
+++ b/search.json
@@ -1 +1 @@
-[{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"How to conduct AMR data analysis","text":"Conducting AMR data analysis unfortunately requires -depth knowledge different scientific fields, makes hard right. least, requires: Good questions (always start !) thorough understanding (clinical) epidemiology, understand clinical epidemiological relevance possible bias results thorough understanding (clinical) microbiology/infectious diseases, understand microorganisms causal infections implications pharmaceutical treatment, well understanding intrinsic acquired microbial resistance Experience data analysis microbiological tests results, understand determination limitations MIC values interpretations SIR values Availability biological taxonomy microorganisms probably normalisation factors pharmaceuticals, defined daily doses (DDD) Available (inter-)national guidelines, profound methods apply course, instantly provide knowledge experience. AMR package, aimed providing (1) tools simplify antimicrobial resistance data cleaning, transformation analysis, (2) methods easily incorporate international guidelines (3) scientifically reliable reference data, including requirements mentioned . AMR package enables standardised reproducible AMR data analysis, application evidence-based rules, determination first isolates, translation various codes microorganisms antimicrobial agents, determination (multi-drug) resistant microorganisms, calculation antimicrobial resistance, prevalence future trends.","code":""},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"preparation","dir":"Articles","previous_headings":"","what":"Preparation","title":"How to conduct AMR data analysis","text":"tutorial, create fake demonstration data work . can skip Cleaning data already data ready. start analysis, try make structure data generally look like :","code":""},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"needed-r-packages","dir":"Articles","previous_headings":"Preparation","what":"Needed R packages","title":"How to conduct AMR data analysis","text":"many uses R, need additional packages AMR data analysis. package works closely together tidyverse packages dplyr ggplot2 RStudio. tidyverse tremendously improves way conduct data science - allows natural way writing syntaxes creating beautiful plots R. also use cleaner package, can used cleaning data creating frequency tables.","code":"library(dplyr) library(ggplot2) library(AMR) library(cleaner) # (if not yet installed, install with:) # install.packages(c(\"dplyr\", \"ggplot2\", \"AMR\", \"cleaner\"))"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"creation-of-data","dir":"Articles","previous_headings":"","what":"Creation of data","title":"How to conduct AMR data analysis","text":"create fake example data use analysis. AMR data analysis, need least: patient ID, name code microorganism, date antimicrobial results (antibiogram). also include specimen type (e.g. filter blood urine), ward type (e.g. filter ICUs). additional columns (like hospital name, patients gender even [well-defined] clinical properties) can comparative analysis, tutorial demonstrate .","code":""},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"patients","dir":"Articles","previous_headings":"Creation of data","what":"Patients","title":"How to conduct AMR data analysis","text":"start patients, need unique list patients. LETTERS object available R - ’s vector 26 characters: Z. patients object just created now vector length 260, values (patient IDs) varying A1 Z10. Now also set gender patients, putting ID gender table: first 135 patient IDs now male, 125 female.","code":"patients <- unlist(lapply(LETTERS, paste0, 1:10)) patients_table <- data.frame( patient_id = patients, gender = c( rep(\"M\", 135), rep(\"F\", 125) ) )"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"dates","dir":"Articles","previous_headings":"Creation of data","what":"Dates","title":"How to conduct AMR data analysis","text":"Let’s pretend data consists blood cultures isolates 1 January 2010 1 January 2018. dates object now contains days date range.","code":"dates <- seq(as.Date(\"2010-01-01\"), as.Date(\"2018-01-01\"), by = \"day\")"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"microorganisms","dir":"Articles","previous_headings":"Creation of data > Dates","what":"Microorganisms","title":"How to conduct AMR data analysis","text":"tutorial, uses four different microorganisms: Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Klebsiella pneumoniae:","code":"bacteria <- c( \"Escherichia coli\", \"Staphylococcus aureus\", \"Streptococcus pneumoniae\", \"Klebsiella pneumoniae\" )"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"put-everything-together","dir":"Articles","previous_headings":"Creation of data","what":"Put everything together","title":"How to conduct AMR data analysis","text":"Using sample() function, can randomly select items objects defined earlier. let fake data reflect reality bit, also approximately define probabilities bacteria antibiotic results, using random_sir() function. Using left_join() function dplyr package, can ‘map’ gender patient ID using patients_table object created earlier: resulting data set contains 20 000 blood culture isolates. head() function can preview first 6 rows data set: Now, let’s start cleaning analysis!","code":"sample_size <- 20000 data <- data.frame( date = sample(dates, size = sample_size, replace = TRUE), patient_id = sample(patients, size = sample_size, replace = TRUE), hospital = sample( c( \"Hospital A\", \"Hospital B\", \"Hospital C\", \"Hospital D\" ), size = sample_size, replace = TRUE, prob = c(0.30, 0.35, 0.15, 0.20) ), bacteria = sample(bacteria, size = sample_size, replace = TRUE, prob = c(0.50, 0.25, 0.15, 0.10) ), AMX = random_sir(sample_size, prob_sir = c(0.35, 0.60, 0.05)), AMC = random_sir(sample_size, prob_sir = c(0.15, 0.75, 0.10)), CIP = random_sir(sample_size, prob_sir = c(0.20, 0.80, 0.00)), GEN = random_sir(sample_size, prob_sir = c(0.08, 0.92, 0.00)) ) data <- data %>% left_join(patients_table) head(data)"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"cleaning-the-data","dir":"Articles","previous_headings":"","what":"Cleaning the data","title":"How to conduct AMR data analysis","text":"also created package dedicated data cleaning checking, called cleaner package. freq() function can used create frequency tables. example, gender variable: Frequency table Class: character Length: 20,000 Available: 20,000 (100%, NA: 0 = 0%) Unique: 2 Shortest: 1 Longest: 1 , can draw least two conclusions immediately. data scientists perspective, data looks clean: values M F. researchers perspective: slightly men. Nothing didn’t already know. data already quite clean, still need transform variables. bacteria column now consists text, want add variables based microbial IDs later . , transform column valid IDs. mutate() function dplyr package makes really easy: also want transform antibiotics, real life data don’t know really clean. .sir() function ensures reliability reproducibility kind variables. is_sir_eligible() can check columns probably columns SIR test results. Using mutate() across(), can apply transformation formal class: Finally, apply EUCAST rules antimicrobial results. Europe, medical microbiological laboratories already apply rules. package features latest insights intrinsic resistance exceptional phenotypes. Moreover, eucast_rules() function can also apply additional rules, like forcing ampicillin = R amoxicillin/clavulanic acid = R. amoxicillin (column AMX) amoxicillin/clavulanic acid (column AMC) data generated randomly, rows undoubtedly contain AMX = S AMC = R, technically impossible. eucast_rules() fixes :","code":"data %>% freq(gender) data <- data %>% mutate(bacteria = as.mo(bacteria)) is_sir_eligible(data) # [1] FALSE FALSE FALSE FALSE TRUE TRUE TRUE TRUE FALSE colnames(data)[is_sir_eligible(data)] # [1] \"AMX\" \"AMC\" \"CIP\" \"GEN\" data <- data %>% mutate(across(where(is_sir_eligible), as.sir)) data <- eucast_rules(data, col_mo = \"bacteria\", rules = \"all\")"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"adding-new-variables","dir":"Articles","previous_headings":"","what":"Adding new variables","title":"How to conduct AMR data analysis","text":"Now microbial ID, can add taxonomic properties:","code":"data <- data %>% mutate( gramstain = mo_gramstain(bacteria), genus = mo_genus(bacteria), species = mo_species(bacteria) )"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"first-isolates","dir":"Articles","previous_headings":"Adding new variables","what":"First isolates","title":"How to conduct AMR data analysis","text":"also need know isolates can actually use analysis. conduct analysis antimicrobial resistance, must include first isolate every patient per episode (Hindler et al., Clin Infect Dis. 2007). , easily get overestimate underestimate resistance antibiotic. Imagine patient admitted MRSA found 5 different blood cultures following weeks (yes, countries like Netherlands blood drawing policies). resistance percentage oxacillin isolates overestimated, included MRSA . clearly selection bias. Clinical Laboratory Standards Institute (CLSI) appoints follows: (…) preparing cumulative antibiogram guide clinical decisions empirical antimicrobial therapy initial infections, first isolate given species per patient, per analysis period (eg, one year) included, irrespective body site, antimicrobial susceptibility profile, phenotypical characteristics (eg, biotype). first isolate easily identified, cumulative antimicrobial susceptibility test data prepared using first isolate generally comparable cumulative antimicrobial susceptibility test data calculated methods, providing duplicate isolates excluded. M39-A4 Analysis Presentation Cumulative Antimicrobial Susceptibility Test Data, 4th Edition. CLSI, 2014. Chapter 6.4 AMR package includes methodology first_isolate() function able apply four different methods defined Hindler et al. 2007: phenotype-based, episode-based, patient-based, isolate-based. right method depends goals analysis, default phenotype-based method case method properly correct duplicate isolates. method also takes account antimicrobial susceptibility test results using all_microbials(). Read methods first_isolate() page. outcome function can easily added data: 61% suitable resistance analysis! can now filter filter() function, also dplyr package: future use, two syntaxes can shortened: end 12 198 isolates analysis. Now data looks like: Time analysis!","code":"data <- data %>% mutate(first = first_isolate(info = TRUE)) # Determining first isolates using an episode length of 365 days # ℹ Using column 'bacteria' as input for col_mo. # ℹ Using column 'date' as input for col_date. # ℹ Using column 'patient_id' as input for col_patient_id. # Basing inclusion on all antimicrobial results, using a points threshold of # 2 # Including isolates from ICU. # => Found 12,198 'phenotype-based' first isolates (61.0% of total where a # microbial ID was available) data_1st <- data %>% filter(first == TRUE) data_1st <- data %>% filter_first_isolate() head(data_1st)"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"analysing-the-data","dir":"Articles","previous_headings":"","what":"Analysing the data","title":"How to conduct AMR data analysis","text":"might want start getting idea data distributed. ’s important start, also decides continue analysis. Although package contains convenient function make frequency tables, exploratory data analysis (EDA) primary scope package. Use package like DataExplorer , read free online book Exploratory Data Analysis R Roger D. Peng.","code":""},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"dispersion-of-species","dir":"Articles","previous_headings":"Analysing the data","what":"Dispersion of species","title":"How to conduct AMR data analysis","text":"just get idea species distributed, create frequency table freq() function. created genus species column earlier based microbial ID. paste(), can concatenate together. freq() function can used like base R language intended: can used like dplyr way, easier readable: Frequency table Class: character Length: 12,198 Available: 12,198 (100%, NA: 0 = 0%) Unique: 4 Shortest: 16 Longest: 24","code":"freq(paste(data_1st$genus, data_1st$species)) data_1st %>% freq(genus, species)"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"overview-of-different-bugdrug-combinations","dir":"Articles","previous_headings":"Analysing the data","what":"Overview of different bug/drug combinations","title":"How to conduct AMR data analysis","text":"Using tidyverse selections, can also select filter columns based antibiotic class : want get quick glance number isolates different bug/drug combinations, can use bug_drug_combinations() function: give crude numbers data. calculate antimicrobial resistance sensible way, also correcting results, use resistance() susceptibility() functions.","code":"data_1st %>% filter(any(aminoglycosides() == \"R\")) # ℹ For aminoglycosides() using column 'GEN' (gentamicin) data_1st %>% bug_drug_combinations() %>% head() # show first 6 rows data_1st %>% select(bacteria, aminoglycosides()) %>% bug_drug_combinations() # ℹ For aminoglycosides() using column 'GEN' (gentamicin)"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"resistance-percentages","dir":"Articles","previous_headings":"Analysing the data","what":"Resistance percentages","title":"How to conduct AMR data analysis","text":"functions resistance() susceptibility() can used calculate antimicrobial resistance susceptibility. specific analyses, functions proportion_S(), proportion_SI(), proportion_I(), proportion_IR() proportion_R() can used determine proportion specific antimicrobial outcome. functions contain minimum argument, denoting minimum required number test results returning value. functions otherwise return NA. default minimum = 30, following CLSI M39-A4 guideline applying microbial epidemiology. per EUCAST guideline 2019, calculate resistance proportion R (proportion_R(), equal resistance()) susceptibility proportion S (proportion_SI(), equal susceptibility()). functions can used : can used conjunction group_by() summarise(), dplyr package: course convenient know number isolates responsible percentages. purpose n_sir() can used, works exactly like n_distinct() dplyr package. counts isolates available every group (.e. values S, R): functions can also used get proportion multiple antibiotics, calculate empiric susceptibility combination therapies easily: curious resistance within certain antibiotic classes, use antibiotic class selector penicillins(), automatically include columns AMX AMC data: make transition next part, let’s see differences previously calculated combination therapies plotted:","code":"data_1st %>% resistance(AMX) # [1] 0.5823086 data_1st %>% group_by(hospital) %>% summarise(amoxicillin = resistance(AMX)) data_1st %>% group_by(hospital) %>% summarise( amoxicillin = resistance(AMX), available = n_sir(AMX) ) data_1st %>% group_by(genus) %>% summarise( amoxiclav = susceptibility(AMC), gentamicin = susceptibility(GEN), amoxiclav_genta = susceptibility(AMC, GEN) ) data_1st %>% # group by hospital group_by(hospital) %>% # / -> select all penicillins in the data for calculation # | / -> use resistance() for all peni's per hospital # | | / -> print as percentages summarise(across(penicillins(), resistance, as_percent = TRUE)) %>% # format the antibiotic column names, using so-called snake case, # so 'Amoxicillin/clavulanic acid' becomes 'amoxicillin_clavulanic_acid' rename_with(set_ab_names, penicillins()) data_1st %>% group_by(genus) %>% summarise( \"1. Amoxi/clav\" = susceptibility(AMC), \"2. Gentamicin\" = susceptibility(GEN), \"3. Amoxi/clav + genta\" = susceptibility(AMC, GEN) ) %>% # pivot_longer() from the tidyr package \"lengthens\" data: tidyr::pivot_longer(-genus, names_to = \"antibiotic\") %>% ggplot(aes( x = genus, y = value, fill = antibiotic )) + geom_col(position = \"dodge2\")"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"plots","dir":"Articles","previous_headings":"Analysing the data","what":"Plots","title":"How to conduct AMR data analysis","text":"show results plots, R users nowadays use ggplot2 package. package lets create plots layers. can read website. quick example look like syntaxes: AMR package contains functions extend ggplot2 package, example geom_sir(). automatically transforms data count_df() proportion_df() show results stacked bars. simplest shortest example: Omit translate_ab = FALSE antibiotic codes (AMX, AMC, CIP, GEN) translated official names (amoxicillin, amoxicillin/clavulanic acid, ciprofloxacin, gentamicin). group e.g. genus column add additional functions package, can create : simplify , also created ggplot_sir() function, combines almost functions:","code":"ggplot( data = a_data_set, mapping = aes( x = year, y = value ) ) + geom_col() + labs( title = \"A title\", subtitle = \"A subtitle\", x = \"My X axis\", y = \"My Y axis\" ) # or as short as: ggplot(a_data_set) + geom_bar(aes(year)) ggplot(data_1st) + geom_sir(translate_ab = FALSE) # group the data on `genus` ggplot(data_1st %>% group_by(genus)) + # create bars with genus on x axis # it looks for variables with class `sir`, # of which we have 4 (earlier created with `as.sir`) geom_sir(x = \"genus\") + # split plots on antibiotic facet_sir(facet = \"antibiotic\") + # set colours to the SIR interpretations (colour-blind friendly) scale_sir_colours() + # show percentages on y axis scale_y_percent(breaks = 0:4 * 25) + # turn 90 degrees, to make it bars instead of columns coord_flip() + # add labels labs( title = \"Resistance per genus and antibiotic\", subtitle = \"(this is fake data)\" ) + # and print genus in italic to follow our convention # (is now y axis because we turned the plot) theme(axis.text.y = element_text(face = \"italic\")) data_1st %>% group_by(genus) %>% ggplot_sir( x = \"genus\", facet = \"antibiotic\", breaks = 0:4 * 25, datalabels = FALSE ) + coord_flip()"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"plotting-mic-and-disk-diffusion-values","dir":"Articles","previous_headings":"Analysing the data > Plots","what":"Plotting MIC and disk diffusion values","title":"How to conduct AMR data analysis","text":"AMR package also extends plot() ggplot2::autoplot() functions plotting minimum inhibitory concentrations (MIC, created .mic()) disk diffusion diameters (created .disk()). random_mic() random_disk() functions, can generate sampled values new data types (S3 classes) : also specific, generating MICs likely found E. coli ciprofloxacin: plot() autoplot() function, can define microorganism antimicrobial agent way. add interpretation values according chosen guidelines (defaults latest EUCAST guideline). Default colours colour-blind friendly, maintaining convention e.g. ‘susceptible’ green ‘resistant’ red: disk diffusion values, much difference plotting: using ggplot2 package, now choosing latest implemented CLSI guideline (notice EUCAST-specific term “Susceptible, incr. exp.” changed “Intermediate”):","code":"mic_values <- random_mic(size = 100) mic_values # Class 'mic' # [1] 0.01 >=256 0.5 64 64 >=256 0.005 1 >=256 # [10] 16 4 32 1 2 64 0.0625 0.0625 8 # [19] 64 2 0.01 8 1 0.002 0.5 0.5 0.002 # [28] 0.0625 0.005 32 2 0.01 1 4 64 8 # [37] 0.125 32 0.125 0.002 >=256 0.005 0.002 2 8 # [46] >=256 >=256 0.01 32 0.002 64 0.5 8 2 # [55] 0.25 4 0.002 0.002 0.125 8 0.25 <=0.001 32 # [64] <=0.001 <=0.001 0.002 >=256 0.002 0.5 0.125 0.01 <=0.001 # [73] 2 8 0.01 0.25 128 0.025 128 0.25 0.005 # [82] 0.01 0.002 32 32 1 0.5 >=256 2 0.025 # [91] 4 8 4 0.25 0.5 0.5 1 0.01 32 # [100] 0.5 # base R: plot(mic_values) # ggplot2: autoplot(mic_values) mic_values <- random_mic(size = 100, mo = \"E. coli\", ab = \"cipro\") # base R: plot(mic_values, mo = \"E. coli\", ab = \"cipro\") # ggplot2: autoplot(mic_values, mo = \"E. coli\", ab = \"cipro\") disk_values <- random_disk(size = 100, mo = \"E. coli\", ab = \"cipro\") disk_values # Class 'disk' # [1] 24 28 29 21 30 30 22 20 23 25 31 28 24 20 25 18 17 21 28 24 19 31 28 25 17 # [26] 30 31 25 26 18 29 27 29 24 23 31 18 22 22 31 20 24 27 18 18 29 27 30 25 27 # [51] 17 29 20 26 24 18 26 28 22 30 29 20 26 28 30 24 19 19 26 17 22 22 17 30 24 # [76] 17 27 20 23 23 18 30 27 21 24 19 25 23 24 20 18 30 20 23 22 25 18 30 28 21 # base R: plot(disk_values, mo = \"E. coli\", ab = \"cipro\") autoplot( disk_values, mo = \"E. coli\", ab = \"cipro\", guideline = \"CLSI\" )"},{"path":"https://msberends.github.io/AMR/articles/AMR.html","id":"independence-test","dir":"Articles","previous_headings":"Analysing the data","what":"Independence test","title":"How to conduct AMR data analysis","text":"next example uses example_isolates data set. data set included package contains 2,000 microbial isolates full antibiograms. reflects reality can used practise AMR data analysis. compare resistance amoxicillin/clavulanic acid (column FOS) ICU clinical wards. input fisher.test() can retrieved transformation like : can apply test now : can seen, p value practically zero (0.0000002263247), means amoxicillin/clavulanic acid resistance found isolates patients ICUs clinical wards really different.","code":"# use package 'tidyr' to pivot data: library(tidyr) check_FOS <- example_isolates %>% filter(ward %in% c(\"ICU\", \"Clinical\")) %>% # filter on only these wards select(ward, AMC) %>% # select the wards and amoxi/clav group_by(ward) %>% # group on the wards count_df(combine_SI = TRUE) %>% # count all isolates per group (ward) pivot_wider( names_from = ward, # transform output so \"ICU\" and \"Clinical\" are columns values_from = value ) %>% select(ICU, Clinical) %>% # and only select these columns as.matrix() # transform to a good old matrix for fisher.test() check_FOS # ICU Clinical # [1,] 396 942 # [2,] 184 240 # do Fisher's Exact Test fisher.test(check_FOS) # # Fisher's Exact Test for Count Data # # data: check_FOS # p-value = 2.263e-07 # alternative hypothesis: true odds ratio is not equal to 1 # 95 percent confidence interval: # 0.435261 0.691614 # sample estimates: # odds ratio # 0.5485079"},{"path":"https://msberends.github.io/AMR/articles/EUCAST.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"How to apply EUCAST rules","text":"EUCAST rules? European Committee Antimicrobial Susceptibility Testing (EUCAST) states website: EUCAST expert rules tabulated collection expert knowledge intrinsic resistances, exceptional resistance phenotypes interpretive rules may applied antimicrobial susceptibility testing order reduce errors make appropriate recommendations reporting particular resistances. Europe, lot medical microbiological laboratories already apply rules (Brown et al., 2015). package features latest insights intrinsic resistance unusual phenotypes (v3.3, 2021). Moreover, eucast_rules() function use purpose can also apply additional rules, like forcing ampicillin = R isolates amoxicillin/clavulanic acid = R.","code":""},{"path":"https://msberends.github.io/AMR/articles/EUCAST.html","id":"examples","dir":"Articles","previous_headings":"","what":"Examples","title":"How to apply EUCAST rules","text":"rules can used discard impossible bug-drug combinations data. example, Klebsiella produces beta-lactamase prevents ampicillin (amoxicillin) working . words, practically every strain Klebsiella resistant ampicillin. Sometimes, laboratory data can still contain strains ampicillin susceptible ampicillin. antibiogram available identification available, antibiogram re-interpreted based identification (namely, Klebsiella). EUCAST expert rules solve , can applied using eucast_rules(): convenient function mo_is_intrinsic_resistant() uses guideline, allows check one specific microorganisms antibiotics: EUCAST rules can used correction, can also used filling known resistance susceptibility based results antimicrobials drugs. process called interpretive reading, basically form imputation, part eucast_rules() function well:","code":"oops <- data.frame( mo = c( \"Klebsiella\", \"Escherichia\" ), ampicillin = \"S\" ) oops # mo ampicillin # 1 Klebsiella S # 2 Escherichia S eucast_rules(oops, info = FALSE) # mo ampicillin # 1 Klebsiella R # 2 Escherichia S mo_is_intrinsic_resistant( c(\"Klebsiella\", \"Escherichia\"), \"ampicillin\" ) # [1] TRUE FALSE mo_is_intrinsic_resistant( \"Klebsiella\", c(\"ampicillin\", \"kanamycin\") ) # [1] TRUE FALSE data <- data.frame( mo = c( \"Staphylococcus aureus\", \"Enterococcus faecalis\", \"Escherichia coli\", \"Klebsiella pneumoniae\", \"Pseudomonas aeruginosa\" ), VAN = \"-\", # Vancomycin AMX = \"-\", # Amoxicillin COL = \"-\", # Colistin CAZ = \"-\", # Ceftazidime CXM = \"-\", # Cefuroxime PEN = \"S\", # Benzylenicillin FOX = \"S\", # Cefoxitin stringsAsFactors = FALSE ) data eucast_rules(data)"},{"path":"https://msberends.github.io/AMR/articles/MDR.html","id":"type-of-input","dir":"Articles","previous_headings":"","what":"Type of input","title":"How to determine multi-drug resistance (MDR)","text":"mdro() function takes data set input, regular data.frame. tries automatically determine right columns info isolates, name species columns results antimicrobial agents. See help page info set right settings data command ?mdro. WHONET data (data), settings automatically set correctly.","code":""},{"path":"https://msberends.github.io/AMR/articles/MDR.html","id":"guidelines","dir":"Articles","previous_headings":"","what":"Guidelines","title":"How to determine multi-drug resistance (MDR)","text":"mdro() function support multiple guidelines. can select guideline guideline parameter. Currently supported guidelines (case-insensitive): guideline = \"CMI2012\" (default) Magiorakos AP, Srinivasan et al. “Multidrug-resistant, extensively drug-resistant pandrug-resistant bacteria: international expert proposal interim standard definitions acquired resistance.” Clinical Microbiology Infection (2012) (link) guideline = \"EUCAST3.2\" (simply guideline = \"EUCAST\") European international guideline - EUCAST Expert Rules Version 3.2 “Intrinsic Resistance Unusual Phenotypes” (link) guideline = \"EUCAST3.1\" European international guideline - EUCAST Expert Rules Version 3.1 “Intrinsic Resistance Exceptional Phenotypes Tables” (link) guideline = \"TB\" international guideline multi-drug resistant tuberculosis - World Health Organization “Companion handbook guidelines programmatic management drug-resistant tuberculosis” (link) guideline = \"MRGN\" German national guideline - Mueller et al. (2015) Antimicrobial Resistance Infection Control 4:7. DOI: 10.1186/s13756-015-0047-6 guideline = \"BRMO\" Dutch national guideline - Rijksinstituut voor Volksgezondheid en Milieu “WIP-richtlijn BRMO (Bijzonder Resistente Micro-Organismen) (ZKH)” (link) Please suggest (country-specific) guidelines letting us know: https://github.com/msberends/AMR/issues/new.","code":""},{"path":"https://msberends.github.io/AMR/articles/MDR.html","id":"custom-guidelines","dir":"Articles","previous_headings":"Guidelines","what":"Custom Guidelines","title":"How to determine multi-drug resistance (MDR)","text":"can also use custom guideline. Custom guidelines can set custom_mdro_guideline() function. great importance custom rules determine MDROs hospital, e.g., rules dependent ward, state contact isolation variables data. familiar case_when() dplyr package, recognise input method set rules. Rules must set using R considers ‘formula notation’: row/isolate matches first rule, value first ~ (case ‘Elderly Type ’) set MDRO value. Otherwise, second rule tried . maximum number rules unlimited. can print rules set console overview. Colours help reading console supports colours. outcome function can used guideline argument mdro() function: rules set (custom object case) exported shared file location using saveRDS() collaborate multiple users. custom rules set imported using readRDS().","code":"custom <- custom_mdro_guideline( CIP == \"R\" & age > 60 ~ \"Elderly Type A\", ERY == \"R\" & age > 60 ~ \"Elderly Type B\" ) custom # A set of custom MDRO rules: # 1. If CIP is \"R\" and age is higher than 60 then: Elderly Type A # 2. If ERY is \"R\" and age is higher than 60 then: Elderly Type B # 3. Otherwise: Negative # # Unmatched rows will return NA. # Results will be of class 'factor', with ordered levels: Negative < Elderly Type A < Elderly Type B x <- mdro(example_isolates, guideline = custom) table(x) # x # Negative Elderly Type A Elderly Type B # 1070 198 732"},{"path":"https://msberends.github.io/AMR/articles/MDR.html","id":"examples","dir":"Articles","previous_headings":"","what":"Examples","title":"How to determine multi-drug resistance (MDR)","text":"mdro() function always returns ordered factor predefined guidelines. example, output default guideline Magiorakos et al. returns factor levels ‘Negative’, ‘MDR’, ‘XDR’ ‘PDR’ order. next example uses example_isolates data set. data set included package contains full antibiograms 2,000 microbial isolates. reflects reality can used practise AMR data analysis. test MDR/XDR/PDR guideline data set, get: (16 isolates test results) Frequency table Class: factor > ordered (numeric) Length: 2,000 Levels: 4: Negative < Multi-drug-resistant (MDR) < Extensively drug-resistant … Available: 1,729 (86.45%, NA: 271 = 13.55%) Unique: 2 another example, create data set determine multi-drug resistant TB: column names automatically verified valid drug names codes, worked exactly way: data set now looks like : can now add interpretation MDR-TB data set. can use: shortcut mdr_tb(): Create frequency table results: Frequency table Class: factor > ordered (numeric) Length: 5,000 Levels: 5: Negative < Mono-resistant < Poly-resistant < Multi-drug-resistant <… Available: 5,000 (100%, NA: 0 = 0%) Unique: 5","code":"library(dplyr) # to support pipes: %>% library(cleaner) # to create frequency tables example_isolates %>% mdro() %>% freq() # show frequency table of the result # Warning: in mdro(): NA introduced for isolates where the available percentage of # antimicrobial classes was below 50% (set with pct_required_classes) # random_sir() is a helper function to generate # a random vector with values S, I and R my_TB_data <- data.frame( rifampicin = random_sir(5000), isoniazid = random_sir(5000), gatifloxacin = random_sir(5000), ethambutol = random_sir(5000), pyrazinamide = random_sir(5000), moxifloxacin = random_sir(5000), kanamycin = random_sir(5000) ) my_TB_data <- data.frame( RIF = random_sir(5000), INH = random_sir(5000), GAT = random_sir(5000), ETH = random_sir(5000), PZA = random_sir(5000), MFX = random_sir(5000), KAN = random_sir(5000) ) head(my_TB_data) # rifampicin isoniazid gatifloxacin ethambutol pyrazinamide moxifloxacin # 1 R R R I S I # 2 S I R S I I # 3 R S R I R R # 4 I I I I R R # 5 I R I R S R # 6 S R S I I I # kanamycin # 1 S # 2 R # 3 S # 4 I # 5 S # 6 S mdro(my_TB_data, guideline = \"TB\") my_TB_data$mdr <- mdr_tb(my_TB_data) # ℹ No column found as input for col_mo, assuming all rows contain # Mycobacterium tuberculosis. freq(my_TB_data$mdr)"},{"path":[]},{"path":"https://msberends.github.io/AMR/articles/PCA.html","id":"transforming","dir":"Articles","previous_headings":"","what":"Transforming","title":"How to conduct principal component analysis (PCA) for AMR","text":"PCA, need transform AMR data first. example_isolates data set package looks like: Now transform data set resistance percentages per taxonomic order genus:","code":"library(AMR) library(dplyr) glimpse(example_isolates) # Rows: 2,000 # Columns: 46 # $ date 2002-01-02, 2002-01-03, 2002-01-07, 2002-01-07, 2002-01-13, 2… # $ patient \"A77334\", \"A77334\", \"067927\", \"067927\", \"067927\", \"067927\", \"4… # $ age 65, 65, 45, 45, 45, 45, 78, 78, 45, 79, 67, 67, 71, 71, 75, 50… # $ gender \"F\", \"F\", \"F\", \"F\", \"F\", \"F\", \"M\", \"M\", \"F\", \"F\", \"M\", \"M\", \"M… # $ ward \"Clinical\", \"Clinical\", \"ICU\", \"ICU\", \"ICU\", \"ICU\", \"Clinical\"… # $ mo \"B_ESCHR_COLI\", \"B_ESCHR_COLI\", \"B_STPHY_EPDR\", \"B_STPHY_EPDR\",… # $ PEN R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, S,… # $ OXA NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ FLC NA, NA, R, R, R, R, S, S, R, S, S, S, NA, NA, NA, NA, NA, R, R… # $ AMX NA, NA, NA, NA, NA, NA, R, R, NA, NA, NA, NA, NA, NA, R, NA, N… # $ AMC I, I, NA, NA, NA, NA, S, S, NA, NA, S, S, I, I, R, I, I, NA, N… # $ AMP NA, NA, NA, NA, NA, NA, R, R, NA, NA, NA, NA, NA, NA, R, NA, N… # $ TZP NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ CZO NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, R, NA,… # $ FEP NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ CXM I, I, R, R, R, R, S, S, R, S, S, S, S, S, NA, S, S, R, R, S, S… # $ FOX NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, R, NA,… # $ CTX NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, S, S, NA, S, S… # $ CAZ NA, NA, R, R, R, R, R, R, R, R, R, R, NA, NA, NA, S, S, R, R, … # $ CRO NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, S, S, NA, S, S… # $ GEN NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ TOB NA, NA, NA, NA, NA, NA, S, S, NA, NA, NA, NA, S, S, NA, NA, NA… # $ AMK NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ KAN NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ TMP R, R, S, S, R, R, R, R, S, S, NA, NA, S, S, S, S, S, R, R, R, … # $ SXT R, R, S, S, NA, NA, NA, NA, S, S, NA, NA, S, S, S, S, S, NA, N… # $ NIT NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, R,… # $ FOS NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ LNZ R, R, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, R, R, R, R, R, N… # $ CIP NA, NA, NA, NA, NA, NA, NA, NA, S, S, NA, NA, NA, NA, NA, S, S… # $ MFX NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ VAN R, R, S, S, S, S, S, S, S, S, NA, NA, R, R, R, R, R, S, S, S, … # $ TEC R, R, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, R, R, R, R, R, N… # $ TCY R, R, S, S, S, S, S, S, S, I, S, S, NA, NA, I, R, R, S, I, R, … # $ TGC NA, NA, S, S, S, S, S, S, S, NA, S, S, NA, NA, NA, R, R, S, NA… # $ DOX NA, NA, S, S, S, S, S, S, S, NA, S, S, NA, NA, NA, R, R, S, NA… # $ ERY R, R, R, R, R, R, S, S, R, S, S, S, R, R, R, R, R, R, R, R, S,… # $ CLI R, R, NA, NA, NA, R, NA, NA, NA, NA, NA, NA, R, R, R, R, R, NA… # $ AZM R, R, R, R, R, R, S, S, R, S, S, S, R, R, R, R, R, R, R, R, S,… # $ IPM NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, S, S, NA, S, S… # $ MEM NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ MTR NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ CHL NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ COL NA, NA, R, R, R, R, R, R, R, R, R, R, NA, NA, NA, R, R, R, R, … # $ MUP NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA… # $ RIF R, R, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, R, R, R, R, R, N… resistance_data <- example_isolates %>% group_by( order = mo_order(mo), # group on anything, like order genus = mo_genus(mo) ) %>% # and genus as we do here summarise_if(is.sir, resistance) %>% # then get resistance of all drugs select( order, genus, AMC, CXM, CTX, CAZ, GEN, TOB, TMP, SXT ) # and select only relevant columns head(resistance_data) # # A tibble: 6 × 10 # # Groups: order [5] # order genus AMC CXM CTX CAZ GEN TOB TMP SXT # # 1 (unknown order) (unknown ge… NA NA NA NA NA NA NA NA # 2 Actinomycetales Schaalia NA NA NA NA NA NA NA NA # 3 Bacteroidales Bacteroides NA NA NA NA NA NA NA NA # 4 Campylobacterales Campylobact… NA NA NA NA NA NA NA NA # 5 Caryophanales Gemella NA NA NA NA NA NA NA NA # 6 Caryophanales Listeria NA NA NA NA NA NA NA NA"},{"path":"https://msberends.github.io/AMR/articles/PCA.html","id":"perform-principal-component-analysis","dir":"Articles","previous_headings":"","what":"Perform principal component analysis","title":"How to conduct principal component analysis (PCA) for AMR","text":"new pca() function automatically filter rows contain numeric values selected variables, now need : result can reviewed good old summary() function: Good news. first two components explain total 93.3% variance (see PC1 PC2 values Proportion Variance. can create -called biplot base R biplot() function, see antimicrobial resistance per drug explain difference per microorganism.","code":"pca_result <- pca(resistance_data) # ℹ Columns selected for PCA: \"AMC\", \"CAZ\", \"CTX\", \"CXM\", \"GEN\", \"SXT\", \"TMP\" # and \"TOB\". Total observations available: 7. summary(pca_result) # Groups (n=4, named as 'order'): # [1] \"Caryophanales\" \"Enterobacterales\" \"Lactobacillales\" \"Pseudomonadales\" # Importance of components: # PC1 PC2 PC3 PC4 PC5 PC6 PC7 # Standard deviation 2.1539 1.6807 0.6138 0.33879 0.20808 0.03140 9.577e-17 # Proportion of Variance 0.5799 0.3531 0.0471 0.01435 0.00541 0.00012 0.000e+00 # Cumulative Proportion 0.5799 0.9330 0.9801 0.99446 0.99988 1.00000 1.000e+00 # Groups (n=4, named as 'order'): # [1] \"Caryophanales\" \"Enterobacterales\" \"Lactobacillales\" \"Pseudomonadales\""},{"path":"https://msberends.github.io/AMR/articles/PCA.html","id":"plotting-the-results","dir":"Articles","previous_headings":"","what":"Plotting the results","title":"How to conduct principal component analysis (PCA) for AMR","text":"can’t see explanation points. Perhaps works better new ggplot_pca() function, automatically adds right labels even groups: can also print ellipse per group, edit appearance:","code":"biplot(pca_result) ggplot_pca(pca_result) ggplot_pca(pca_result, ellipse = TRUE) + ggplot2::labs(title = \"An AMR/PCA biplot!\")"},{"path":"https://msberends.github.io/AMR/articles/SPSS.html","id":"spss-sas-stata","dir":"Articles","previous_headings":"","what":"SPSS / SAS / Stata","title":"How to import data from SPSS / SAS / Stata","text":"SPSS (Statistical Package Social Sciences) probably well-known software package statistical analysis. SPSS easier learn R, SPSS click menu run parts analysis. user-friendliness, taught universities particularly useful students new statistics. experience, guess pretty much (bio)medical students know time graduate. SAS Stata comparable statistical packages popular big industries.","code":""},{"path":"https://msberends.github.io/AMR/articles/SPSS.html","id":"compared-to-r","dir":"Articles","previous_headings":"","what":"Compared to R","title":"How to import data from SPSS / SAS / Stata","text":"said, SPSS easier learn R. SPSS, SAS Stata come major downsides comparing R: R highly modular. official R network (CRAN) features 16,000 packages time writing, AMR package one . packages peer-reviewed publication. Aside official channel, also developers choose submit CRAN, rather keep public repository, like GitHub. may even lot 14,000 packages . Bottom line , can really extend ask somebody . Take example AMR package. Among things, adds reliable reference data R help data cleaning analysis. SPSS, SAS Stata never know valid MIC value Gram stain E. coli . species Klebiella resistant amoxicillin Floxapen® trade name flucloxacillin. facts properties often needed clean existing data, inconvenient software package without reliable reference data. See demonstration. R extremely flexible. write syntax , can anything want. flexibility transforming, arranging, grouping summarising data, drawing plots, endless - SPSS, SAS Stata bound algorithms format styles. may bit flexible, can probably never create specific publication-ready plot without using (paid) software. sometimes write syntaxes SPSS run complete analysis ‘automate’ work, lot less time R. notice writing syntaxes R lot nifty clever SPSS. Still, working statistical package, knowledge (statistically) willing accomplish. R can easily automated. last years, R Markdown really made interesting development. R Markdown, can easily produce reports, whether format Word, PowerPoint, website, PDF document just raw data Excel. even allows use reference file containing layout style (e.g. fonts colours) organisation. use lot generate weekly monthly reports automatically. Just write code enjoy automatically updated reports interval like. even professional environment, create Shiny apps: live manipulation data using custom made website. webdesign knowledge needed (JavaScript, CSS, HTML) almost zero. R huge community. Many R users just ask questions websites like StackOverflow.com, largest online community programmers. time writing, 480 788 R-related questions already asked platform (covers questions answers programming language). experience, questions answered within couple minutes. R understands data type, including SPSS/SAS/Stata. ’s vice versa ’m afraid. can import data source R. example SPSS, SAS Stata (link), Minitab, Epi Info EpiData (link), Excel (link), flat files like CSV, TXT TSV (link), directly databases datawarehouses anywhere world (link). can even scrape websites download tables live internet (link) get results API call transform data one command (link). best part - can export R data formats well. can import SPSS file, analysis neatly R export resulting tables Excel files sharing. R completely free open-source. strings attached. created maintained volunteers believe (data) science open publicly available everybody. SPSS, SAS Stata quite expensive. IBM SPSS Staticstics comes subscriptions nowadays, varying USD 1,300 USD 8,500 per user per year. SAS Analytics Pro costs around USD 10,000 per computer. Stata also business model subscription fees, varying USD 600 USD 2,800 per computer per year, lower prices come limitation number variables can work . still offer benefits R. working midsized small company, can save tens thousands dollars using R instead e.g. SPSS - gaining even functions flexibility. R enthousiasts can much PR want (like ), nobody officially associated affiliated R. really free. R (nowadays) preferred analysis software academic papers. present, R among world powerful statistical languages, generally popular science (Bollmann et al., 2017). reasons, number references R analysis method academic papers rising continuously even surpassed SPSS academic use (Muenchen, 2014). believe thing SPSS , always great user interface easy learn use. Back developed , little competition, let alone R. R didn’t even professional user interface last decade (called RStudio, see ). people used R nineties 2010 almost completely incomparable R used now. language restyled completely volunteers dedicated professionals field data science. SPSS great nothing else compete. now 2023, don’t see reason SPSS better use R. demonstrate first point:","code":"# not all values are valid MIC values: as.mic(0.125) # Class 'mic' # [1] 0.125 as.mic(\"testvalue\") # Class 'mic' # [1] # the Gram stain is available for all bacteria: mo_gramstain(\"E. coli\") # [1] \"Gram-negative\" # Klebsiella is intrinsic resistant to amoxicillin, according to EUCAST: klebsiella_test <- data.frame( mo = \"klebsiella\", amox = \"S\", stringsAsFactors = FALSE ) klebsiella_test # (our original data) # mo amox # 1 klebsiella S eucast_rules(klebsiella_test, info = FALSE) # (the edited data by EUCAST rules) # mo amox # 1 klebsiella R # hundreds of trade names can be translated to a name, trade name or an ATC code: ab_name(\"floxapen\") # [1] \"Flucloxacillin\" ab_tradenames(\"floxapen\") # [1] \"culpen\" \"floxacillin\" \"floxacillin sodium\" # [4] \"floxapen\" \"floxapen sodium salt\" \"fluclox\" # [7] \"flucloxacilina\" \"flucloxacillin\" \"flucloxacilline\" # [10] \"flucloxacillinum\" \"fluorochloroxacillin\" \"staphylex\" ab_atc(\"floxapen\") # [1] \"J01CF05\""},{"path":[]},{"path":"https://msberends.github.io/AMR/articles/SPSS.html","id":"rstudio","dir":"Articles","previous_headings":"Import data from SPSS/SAS/Stata","what":"RStudio","title":"How to import data from SPSS / SAS / Stata","text":"work R, probably best option use RStudio. open-source free desktop environment allows run R code, also supports project management, version management, package management convenient import menus work data sources. can also install RStudio Server private corporate server, brings nothing less complete RStudio software website (home work). import data file, just click Import Dataset Environment tab: additional packages needed, RStudio ask installed beforehand. window opens, can define options (parameters) used import ’re ready go: want named variables imported factors resembles SPSS , use as_factor(). difference :","code":"SPSS_data # # A tibble: 4,203 x 4 # v001 sex status statusage # # 1 10002 1 1 76.6 # 2 10004 0 1 59.1 # 3 10005 1 1 54.5 # 4 10006 1 1 54.1 # 5 10007 1 1 57.7 # 6 10008 1 1 62.8 # 7 10010 0 1 63.7 # 8 10011 1 1 73.1 # 9 10017 1 1 56.7 # 10 10018 0 1 66.6 # # ... with 4,193 more rows as_factor(SPSS_data) # # A tibble: 4,203 x 4 # v001 sex status statusage # # 1 10002 Male alive 76.6 # 2 10004 Female alive 59.1 # 3 10005 Male alive 54.5 # 4 10006 Male alive 54.1 # 5 10007 Male alive 57.7 # 6 10008 Male alive 62.8 # 7 10010 Female alive 63.7 # 8 10011 Male alive 73.1 # 9 10017 Male alive 56.7 # 10 10018 Female alive 66.6 # # ... with 4,193 more rows"},{"path":"https://msberends.github.io/AMR/articles/SPSS.html","id":"base-r","dir":"Articles","previous_headings":"Import data from SPSS/SAS/Stata","what":"Base R","title":"How to import data from SPSS / SAS / Stata","text":"import data SPSS, SAS Stata, can use great haven package : can now import files follows:","code":"# download and install the latest version: install.packages(\"haven\") # load the package you just installed: library(haven)"},{"path":"https://msberends.github.io/AMR/articles/SPSS.html","id":"spss","dir":"Articles","previous_headings":"Import data from SPSS/SAS/Stata > Base R","what":"SPSS","title":"How to import data from SPSS / SAS / Stata","text":"read files SPSS R: forget as_factor(), mentioned . export R objects SPSS file format:","code":"# read any SPSS file based on file extension (best way): read_spss(file = \"path/to/file\") # read .sav or .zsav file: read_sav(file = \"path/to/file\") # read .por file: read_por(file = \"path/to/file\") # save as .sav file: write_sav(data = yourdata, path = \"path/to/file\") # save as compressed .zsav file: write_sav(data = yourdata, path = \"path/to/file\", compress = TRUE)"},{"path":"https://msberends.github.io/AMR/articles/SPSS.html","id":"sas","dir":"Articles","previous_headings":"Import data from SPSS/SAS/Stata > Base R","what":"SAS","title":"How to import data from SPSS / SAS / Stata","text":"read files SAS R: export R objects SAS file format:","code":"# read .sas7bdat + .sas7bcat files: read_sas(data_file = \"path/to/file\", catalog_file = NULL) # read SAS transport files (version 5 and version 8): read_xpt(file = \"path/to/file\") # save as regular SAS file: write_sas(data = yourdata, path = \"path/to/file\") # the SAS transport format is an open format # (required for submission of the data to the FDA) write_xpt(data = yourdata, path = \"path/to/file\", version = 8)"},{"path":"https://msberends.github.io/AMR/articles/SPSS.html","id":"stata","dir":"Articles","previous_headings":"Import data from SPSS/SAS/Stata > Base R","what":"Stata","title":"How to import data from SPSS / SAS / Stata","text":"read files Stata R: export R objects Stata file format:","code":"# read .dta file: read_stata(file = \"/path/to/file\") # works exactly the same: read_dta(file = \"/path/to/file\") # save as .dta file, Stata version 14: # (supports Stata v8 until v15 at the time of writing) write_dta(data = yourdata, path = \"/path/to/file\", version = 14)"},{"path":"https://msberends.github.io/AMR/articles/WHONET.html","id":"import-of-data","dir":"Articles","previous_headings":"","what":"Import of data","title":"How to work with WHONET data","text":"tutorial assumes already imported WHONET data e.g. readxl package. RStudio, can done using menu button ‘Import Dataset’ tab ‘Environment’. Choose option ‘Excel’ select exported file. Make sure date fields imported correctly. example syntax look like : package comes example data set WHONET. use analysis.","code":"library(readxl) data <- read_excel(path = \"path/to/your/file.xlsx\")"},{"path":"https://msberends.github.io/AMR/articles/WHONET.html","id":"preparation","dir":"Articles","previous_headings":"","what":"Preparation","title":"How to work with WHONET data","text":"First, load relevant packages yet . use tidyverse analyses. . don’t know yet, suggest read website: https://www.tidyverse.org/. transform variables simplify automate analysis: Microorganisms transformed microorganism codes (called mo) using Catalogue Life reference data set, contains ~70,000 microorganisms taxonomic kingdoms Bacteria, Fungi Protozoa. tranformation .mo(). function also recognises almost WHONET abbreviations microorganisms. Antimicrobial results interpretations clean valid. words, contain values \"S\", \"\" \"R\". exactly .sir() function . errors warnings, values transformed succesfully. also created package dedicated data cleaning checking, called cleaner package. freq() function can used create frequency tables. let’s check data, couple frequency tables: Frequency table Class: character Length: 500 Available: 500 (100%, NA: 0 = 0%) Unique: 38 Shortest: 11 Longest: 40 (omitted 28 entries, n = 57 [11.4%]) Frequency table Class: factor > ordered > sir (numeric) Length: 500 Levels: 3: S < < R Available: 481 (96.2%, NA: 19 = 3.8%) Unique: 3 Drug: Amoxicillin/clavulanic acid (AMC, J01CR02) Drug group: Beta-lactams/penicillins %SI: 78.59%","code":"library(dplyr) # part of tidyverse library(ggplot2) # part of tidyverse library(AMR) # this package library(cleaner) # to create frequency tables # transform variables data <- WHONET %>% # get microbial ID based on given organism mutate(mo = as.mo(Organism)) %>% # transform everything from \"AMP_ND10\" to \"CIP_EE\" to the new `sir` class mutate_at(vars(AMP_ND10:CIP_EE), as.sir) # our newly created `mo` variable, put in the mo_name() function data %>% freq(mo_name(mo), nmax = 10) # our transformed antibiotic columns # amoxicillin/clavulanic acid (J01CR02) as an example data %>% freq(AMC_ND2)"},{"path":"https://msberends.github.io/AMR/articles/WHONET.html","id":"a-first-glimpse-at-results","dir":"Articles","previous_headings":"","what":"A first glimpse at results","title":"How to work with WHONET data","text":"easy ggplot already give lot information, using included ggplot_sir() function:","code":"data %>% group_by(Country) %>% select(Country, AMP_ND2, AMC_ED20, CAZ_ED10, CIP_ED5) %>% ggplot_sir(translate_ab = \"ab\", facet = \"Country\", datalabels = FALSE)"},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"microorganisms-full-microbial-taxonomy","dir":"Articles","previous_headings":"","what":"microorganisms: Full Microbial Taxonomy","title":"Data sets for download / own use","text":"data set 52 142 rows 22 columns, containing following column names:mo, fullname, status, kingdom, phylum, class, order, family, genus, species, subspecies, rank, ref, source, lpsn, lpsn_parent, lpsn_renamed_to, gbif, gbif_parent, gbif_renamed_to, prevalence snomed. data set R available microorganisms, load AMR package. last updated 6 February 2023 10:57:22 UTC. Find info structure data set . Direct download links: Download original R Data Structure (RDS) file (1.2 MB) Download tab-separated text file (11.3 MB) Download Microsoft Excel workbook (5 MB) Download Apache Feather file (5.4 MB) Download Apache Parquet file (2.6 MB) Download SAS data file (50.9 MB) Download IBM SPSS Statistics data file (16.9 MB) Download Stata DTA file (47.1 MB) NOTE: exported files SAS, SPSS Stata contain first 50 SNOMED codes per record, file size otherwise exceed 100 MB; file size limit GitHub. Advice? Use R instead. tab-separated text file Microsoft Excel workbook contain SNOMED codes comma separated values.","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"source","dir":"Articles","previous_headings":"microorganisms: Full Microbial Taxonomy","what":"Source","title":"Data sets for download / own use","text":"data set contains full microbial taxonomy five kingdoms List Prokaryotic names Standing Nomenclature (LPSN) Global Biodiversity Information Facility (GBIF): Parte, AC et al. (2020). List Prokaryotic names Standing Nomenclature (LPSN) moves DSMZ. International Journal Systematic Evolutionary Microbiology, 70, 5607-5612; . Accessed https://lpsn.dsmz.de 11 December, 2022. GBIF Secretariat (2022). GBIF Backbone Taxonomy. Checklist dataset . Accessed https://www.gbif.org 11 December, 2022. Public Health Information Network Vocabulary Access Distribution System (PHIN VADS). US Edition SNOMED CT 1 September 2020. Value Set Name ‘Microoganism’, OID 2.16.840.1.114222.4.11.1009 (v12). URL: https://phinvads.cdc.gov","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"example-content","dir":"Articles","previous_headings":"microorganisms: Full Microbial Taxonomy","what":"Example content","title":"Data sets for download / own use","text":"Included (sub)species per taxonomic kingdom: Example rows filtering genus Escherichia:","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"antibiotics-antibiotic-antifungal-drugs","dir":"Articles","previous_headings":"","what":"antibiotics: Antibiotic (+Antifungal) Drugs","title":"Data sets for download / own use","text":"data set 483 rows 14 columns, containing following column names:ab, cid, name, group, atc, atc_group1, atc_group2, abbreviations, synonyms, oral_ddd, oral_units, iv_ddd, iv_units loinc. data set R available antibiotics, load AMR package. last updated 30 October 2022 20:05:46 UTC. Find info structure data set . Direct download links: Download original R Data Structure (RDS) file (39 kB) Download tab-separated text file (0.1 MB) Download Microsoft Excel workbook (66 kB) Download Apache Feather file (0.1 MB) Download Apache Parquet file (97 kB) Download SAS data file (1.9 MB) Download IBM SPSS Statistics data file (0.3 MB) Download Stata DTA file (0.4 MB) tab-separated text file Microsoft Excel workbook, SAS, SPSS Stata files contain ATC codes, common abbreviations, trade names LOINC codes comma separated values.","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"source-1","dir":"Articles","previous_headings":"antibiotics: Antibiotic (+Antifungal) Drugs","what":"Source","title":"Data sets for download / own use","text":"data set contains EARS-Net ATC codes gathered WHONET, compound IDs PubChem. also contains brand names (synonyms) found PubChem Defined Daily Doses (DDDs) oral parenteral administration. ATC/DDD index Collaborating Centre Drug Statistics Methodology (note: may used commercial purposes, freely available CC website personal use) PubChem US National Library Medicine WHONET software 2019 LOINC (Logical Observation Identifiers Names Codes)","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"antivirals-antiviral-drugs","dir":"Articles","previous_headings":"","what":"antivirals: Antiviral Drugs","title":"Data sets for download / own use","text":"data set 120 rows 11 columns, containing following column names:av, name, atc, cid, atc_group, synonyms, oral_ddd, oral_units, iv_ddd, iv_units loinc. data set R available antivirals, load AMR package. last updated 13 November 2022 07:46:10 UTC. Find info structure data set . Direct download links: Download original R Data Structure (RDS) file (5 kB) Download tab-separated text file (16 kB) Download Microsoft Excel workbook (16 kB) Download Apache Feather file (15 kB) Download Apache Parquet file (13 kB) Download SAS data file (84 kB) Download IBM SPSS Statistics data file (30 kB) Download Stata DTA file (73 kB) tab-separated text file Microsoft Excel workbook, SAS, SPSS Stata files contain trade names LOINC codes comma separated values.","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"source-2","dir":"Articles","previous_headings":"antivirals: Antiviral Drugs","what":"Source","title":"Data sets for download / own use","text":"data set contains ATC codes gathered compound IDs PubChem. also contains brand names (synonyms) found PubChem Defined Daily Doses (DDDs) oral parenteral administration. ATC/DDD index Collaborating Centre Drug Statistics Methodology (note: may used commercial purposes, freely available CC website personal use) PubChem US National Library Medicine LOINC (Logical Observation Identifiers Names Codes)","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"clinical_breakpoints-interpretation-from-mic-values-disk-diameters-to-sir","dir":"Articles","previous_headings":"","what":"clinical_breakpoints: Interpretation from MIC values & disk diameters to SIR","title":"Data sets for download / own use","text":"data set 18 308 rows 11 columns, containing following column names:guideline, method, site, mo, rank_index, ab, ref_tbl, disk_dose, breakpoint_S, breakpoint_R uti. data set R available clinical_breakpoints, load AMR package. last updated 21 January 2023 22:47:20 UTC. Find info structure data set . Direct download links: Download original R Data Structure (RDS) file (42 kB) Download tab-separated text file (1.9 MB) Download Microsoft Excel workbook (0.8 MB) Download Apache Feather file (0.7 MB) Download Apache Parquet file (87 kB) Download SAS data file (3.6 MB) Download IBM SPSS Statistics data file (2.3 MB) Download Stata DTA file (3.4 MB)","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"source-3","dir":"Articles","previous_headings":"clinical_breakpoints: Interpretation from MIC values & disk diameters to SIR","what":"Source","title":"Data sets for download / own use","text":"data set contains interpretation rules MIC values disk diffusion diameters. Included guidelines CLSI (2013-2022) EUCAST (2013-2022).","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"intrinsic_resistant-intrinsic-bacterial-resistance","dir":"Articles","previous_headings":"","what":"intrinsic_resistant: Intrinsic Bacterial Resistance","title":"Data sets for download / own use","text":"data set 134 634 rows 2 columns, containing following column names:mo ab. data set R available intrinsic_resistant, load AMR package. last updated 16 December 2022 15:10:43 UTC. Find info structure data set . Direct download links: Download original R Data Structure (RDS) file (78 kB) Download tab-separated text file (5.1 MB) Download Microsoft Excel workbook (1.3 MB) Download Apache Feather file (1.2 MB) Download Apache Parquet file (0.2 MB) Download SAS data file (9.8 MB) Download IBM SPSS Statistics data file (7.4 MB) Download Stata DTA file (9.5 MB)","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"source-4","dir":"Articles","previous_headings":"intrinsic_resistant: Intrinsic Bacterial Resistance","what":"Source","title":"Data sets for download / own use","text":"data set contains defined intrinsic resistance EUCAST bug-drug combinations, based ‘EUCAST Expert Rules’ ‘EUCAST Intrinsic Resistance Unusual Phenotypes’ v3.3 (2021).","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"example-content-4","dir":"Articles","previous_headings":"intrinsic_resistant: Intrinsic Bacterial Resistance","what":"Example content","title":"Data sets for download / own use","text":"Example rows filtering Enterobacter cloacae:","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"dosage-dosage-guidelines-from-eucast","dir":"Articles","previous_headings":"","what":"dosage: Dosage Guidelines from EUCAST","title":"Data sets for download / own use","text":"data set 336 rows 9 columns, containing following column names:ab, name, type, dose, dose_times, administration, notes, original_txt eucast_version. data set R available dosage, load AMR package. last updated 14 November 2022 14:20:39 UTC. Find info structure data set . Direct download links: Download original R Data Structure (RDS) file (3 kB) Download tab-separated text file (29 kB) Download Microsoft Excel workbook (19 kB) Download Apache Feather file (16 kB) Download Apache Parquet file (8 kB) Download SAS data file (92 kB) Download IBM SPSS Statistics data file (43 kB) Download Stata DTA file (82 kB)","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"source-5","dir":"Articles","previous_headings":"dosage: Dosage Guidelines from EUCAST","what":"Source","title":"Data sets for download / own use","text":"EUCAST breakpoints used package based dosages data set. Currently included dosages data set meant : ‘EUCAST Clinical Breakpoint Tables’ v11.0 (2021) ‘EUCAST Clinical Breakpoint Tables’ v12.0 (2022).","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"example_isolates-example-data-for-practice","dir":"Articles","previous_headings":"","what":"example_isolates: Example Data for Practice","title":"Data sets for download / own use","text":"data set 2 000 rows 46 columns, containing following column names:date, patient, age, gender, ward, mo, PEN, OXA, FLC, AMX, AMC, AMP, TZP, CZO, FEP, CXM, FOX, CTX, CAZ, CRO, GEN, TOB, AMK, KAN, TMP, SXT, NIT, FOS, LNZ, CIP, MFX, VAN, TEC, TCY, TGC, DOX, ERY, CLI, AZM, IPM, MEM, MTR, CHL, COL, MUP RIF. data set R available example_isolates, load AMR package. last updated 21 January 2023 22:47:20 UTC. Find info structure data set .","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"source-6","dir":"Articles","previous_headings":"example_isolates: Example Data for Practice","what":"Source","title":"Data sets for download / own use","text":"data set contains randomised fictitious data, reflects reality can used practise AMR data analysis.","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"example_isolates_unclean-example-data-for-practice","dir":"Articles","previous_headings":"","what":"example_isolates_unclean: Example Data for Practice","title":"Data sets for download / own use","text":"data set 3 000 rows 8 columns, containing following column names:patient_id, hospital, date, bacteria, AMX, AMC, CIP GEN. data set R available example_isolates_unclean, load AMR package. last updated 27 August 2022 18:49:37 UTC. Find info structure data set .","code":""},{"path":"https://msberends.github.io/AMR/articles/datasets.html","id":"source-7","dir":"Articles","previous_headings":"example_isolates_unclean: Example Data for Practice","what":"Source","title":"Data sets for download / own use","text":"data set contains randomised fictitious data, reflects reality can used practise AMR data analysis.","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/articles/resistance_predict.html","id":"needed-r-packages","dir":"Articles","previous_headings":"","what":"Needed R packages","title":"How to predict antimicrobial resistance","text":"many uses R, need additional packages AMR data analysis. package works closely together tidyverse packages dplyr ggplot2. tidyverse tremendously improves way conduct data science - allows natural way writing syntaxes creating beautiful plots R. AMR package depends packages even extends use functions.","code":"library(dplyr) library(ggplot2) library(AMR) # (if not yet installed, install with:) # install.packages(c(\"tidyverse\", \"AMR\"))"},{"path":"https://msberends.github.io/AMR/articles/resistance_predict.html","id":"prediction-analysis","dir":"Articles","previous_headings":"","what":"Prediction analysis","title":"How to predict antimicrobial resistance","text":"package contains function resistance_predict(), takes input functions AMR data analysis. Based date column, calculates cases per year uses regression model predict antimicrobial resistance. basically easy : function look date column col_date set. running commands, summary regression model printed unless using resistance_predict(..., info = FALSE). text printed summary - actual result (output) function data.frame containing year: number observations, actual observed resistance, estimated resistance standard error estimation: function plot available base R, can extended packages depend output based type input. extended function cope resistance predictions: fastest way plot result. automatically adds right axes, error bars, titles, number available observations type model. also support ggplot2 package custom function ggplot_sir_predict() create appealing plots:","code":"# resistance prediction of piperacillin/tazobactam (TZP): resistance_predict(tbl = example_isolates, col_date = \"date\", col_ab = \"TZP\", model = \"binomial\") # or: example_isolates %>% resistance_predict( col_ab = \"TZP\", model = \"binomial\" ) # to bind it to object 'predict_TZP' for example: predict_TZP <- example_isolates %>% resistance_predict( col_ab = \"TZP\", model = \"binomial\" ) predict_TZP # # A tibble: 32 × 7 # year value se_min se_max observations observed estimated # * # 1 2002 0.2 NA NA 15 0.2 0.0562 # 2 2003 0.0625 NA NA 32 0.0625 0.0616 # 3 2004 0.0854 NA NA 82 0.0854 0.0676 # 4 2005 0.05 NA NA 60 0.05 0.0741 # 5 2006 0.0508 NA NA 59 0.0508 0.0812 # 6 2007 0.121 NA NA 66 0.121 0.0889 # 7 2008 0.0417 NA NA 72 0.0417 0.0972 # 8 2009 0.0164 NA NA 61 0.0164 0.106 # 9 2010 0.0566 NA NA 53 0.0566 0.116 # 10 2011 0.183 NA NA 93 0.183 0.127 # # … with 22 more rows plot(predict_TZP) ggplot_sir_predict(predict_TZP) # choose for error bars instead of a ribbon ggplot_sir_predict(predict_TZP, ribbon = FALSE)"},{"path":"https://msberends.github.io/AMR/articles/resistance_predict.html","id":"choosing-the-right-model","dir":"Articles","previous_headings":"Prediction analysis","what":"Choosing the right model","title":"How to predict antimicrobial resistance","text":"Resistance easily predicted; look vancomycin resistance Gram-positive bacteria, spread (.e. standard error) enormous: Vancomycin resistance 100% ten years, might remain low. can define model model parameter. model chosen generalised linear regression model using binomial distribution, assuming period zero resistance followed period increasing resistance leading slowly resistance. Valid values : vancomycin resistance Gram-positive bacteria, linear model might appropriate: model also available object, attribute:","code":"example_isolates %>% filter(mo_gramstain(mo, language = NULL) == \"Gram-positive\") %>% resistance_predict(col_ab = \"VAN\", year_min = 2010, info = FALSE, model = \"binomial\") %>% ggplot_sir_predict() example_isolates %>% filter(mo_gramstain(mo, language = NULL) == \"Gram-positive\") %>% resistance_predict(col_ab = \"VAN\", year_min = 2010, info = FALSE, model = \"linear\") %>% ggplot_sir_predict() model <- attributes(predict_TZP)$model summary(model)$family # # Family: binomial # Link function: logit summary(model)$coefficients # Estimate Std. Error z value Pr(>|z|) # (Intercept) -200.67944891 46.17315349 -4.346237 1.384932e-05 # year 0.09883005 0.02295317 4.305725 1.664395e-05"},{"path":"https://msberends.github.io/AMR/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Matthijs S. Berends. Author, maintainer. Christian F. Luz. Author, contributor. Dennis Souverein. Author, contributor. Erwin E. . Hassing. Author, contributor. Casper J. Albers. Thesis advisor. Peter Dutey-Magni. Contributor. Judith M. Fonville. Contributor. Alex W. Friedrich. Thesis advisor. Corinna Glasner. Thesis advisor. Eric H. L. C. M. Hazenberg. Contributor. Gwen Knight. Contributor. Annick Lenglet. Contributor. Bart C. Meijer. Contributor. Dmytro Mykhailenko. Contributor. Anton Mymrikov. Contributor. Andrew P. Norgan. Contributor. Sofia Ny. Contributor. Jonas Salm. Contributor. Rogier P. Schade. Contributor. Bhanu N. M. Sinha. Thesis advisor. Anthony Underwood. Contributor. Anita Williams. Contributor.","code":""},{"path":"https://msberends.github.io/AMR/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Berends MS, Luz CF, Friedrich AW, Sinha BNM, Albers CJ, Glasner C (2022). “AMR: R Package Working Antimicrobial Resistance Data.” Journal Statistical Software, 104(3), 1–31. doi:10.18637/jss.v104.i03.","code":"@Article{, title = {{AMR}: An {R} Package for Working with Antimicrobial Resistance Data}, author = {Matthijs S. Berends and Christian F. Luz and Alexander W. Friedrich and Bhanu N. M. Sinha and Casper J. Albers and Corinna Glasner}, journal = {Journal of Statistical Software}, year = {2022}, volume = {104}, number = {3}, pages = {1--31}, doi = {10.18637/jss.v104.i03}, }"},{"path":"https://msberends.github.io/AMR/index.html","id":"the-amr-package-for-r-","dir":"","previous_headings":"","what":"Antimicrobial Resistance Data Analysis","title":"Antimicrobial Resistance Data Analysis","text":"Generates antibiograms - traditional, combined, syndromic, even WISCA Provides full microbiological taxonomy data antimicrobial drugs Applies recent CLSI EUCAST clinical breakpoints MICs disk zones Corrects duplicate isolates, calculates predicts AMR per antibiotic class Integrates WHONET, ATC, EARS-Net, PubChem, LOINC SNOMED CT Works Windows, macOS Linux versions R since R-3.0 completely dependency-free, highly suitable places limited resources https://msberends.github.io/AMR https://doi.org/10.18637/jss.v104.i03","code":""},{"path":"https://msberends.github.io/AMR/index.html","id":"introduction","dir":"","previous_headings":"","what":"Introduction","title":"Antimicrobial Resistance Data Analysis","text":"AMR package free open-source R package zero dependencies simplify analysis prediction Antimicrobial Resistance (AMR) work microbial antimicrobial data properties, using evidence-based methods. aim provide standard clean reproducible AMR data analysis, can therefore empower epidemiological analyses continuously enable surveillance treatment evaluation setting. Many different researchers around globe continually helping us make successful durable project! work published Journal Statistical Software (Volume 104(3); DOI 10.18637/jss.v104.i03) formed basis two PhD theses (DOI 10.33612/diss.177417131 DOI 10.33612/diss.192486375). installing package, R knows ~52,000 distinct microbial species (updated December 2022) ~600 antibiotic, antimycotic antiviral drugs name code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC SNOMED CT), knows valid SIR MIC values. integral breakpoint guidelines CLSI EUCAST included last 10 years. supports can read data format, including WHONET data. package works Windows, macOS Linux versions R since R-3.0 (April 2013). designed work setting, including limited resources. created routine data analysis academic research Faculty Medical Sciences University Groningen, collaboration non-profit organisations Certe Medical Diagnostics Advice Foundation University Medical Center Groningen.","code":""},{"path":"https://msberends.github.io/AMR/index.html","id":"used-in-over-175-countries-translated-into-20-languages","dir":"","previous_headings":"Introduction","what":"Used in over 175 countries, translated into 20 languages","title":"Antimicrobial Resistance Data Analysis","text":"Since first public release early 2018, R package used almost countries world. Click map enlarge see country names. help contributors corners world, AMR package available English, Czech, Chinese, Danish, Dutch, Finnish, French, German, Greek, Italian, Japanese, Norwegian, Polish, Portuguese, Romanian, Russian, Spanish, Swedish, Turkish, Ukrainian. Antimicrobial drug (group) names colloquial microorganism names provided languages.","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/index.html","id":"filtering-and-selecting-data","dir":"","previous_headings":"Practical examples","what":"Filtering and selecting data","title":"Antimicrobial Resistance Data Analysis","text":"defined row filter Gram-negative bacteria intrinsic resistance cefotaxime (mo_is_gram_negative() mo_is_intrinsic_resistant()) column selection two antibiotic groups (aminoglycosides() carbapenems()), reference data microorganisms antibiotics AMR package make sure get meant: base R equivalent : base R snippet work version R since April 2013 (R-3.0).","code":"# AMR works great with dplyr, but it's not required or neccesary library(AMR) library(dplyr) example_isolates %>% mutate(bacteria = mo_fullname()) %>% filter(mo_is_gram_negative(), mo_is_intrinsic_resistant(ab = \"cefotax\")) %>% select(bacteria, aminoglycosides(), carbapenems()) example_isolates$bacteria <- mo_fullname(example_isolates$mo) example_isolates[which(mo_is_gram_negative() & mo_is_intrinsic_resistant(ab = \"cefotax\")), c(\"bacteria\", aminoglycosides(), carbapenems())]"},{"path":"https://msberends.github.io/AMR/index.html","id":"generating-antibiograms","dir":"","previous_headings":"Practical examples","what":"Generating antibiograms","title":"Antimicrobial Resistance Data Analysis","text":"AMR package supports generating traditional, combined, syndromic, even weighted-incidence syndromic combination antibiograms (WISCA). used inside R Markdown Quarto, table printed right output format automatically (markdown, LaTeX, HTML, etc.) using print() antibiogram object. combination antibiograms, clear combined antibiotics yield higher empiric coverage: Like many functions package, antibiograms() comes support 20 languages often detected automatically based system language:","code":"antibiogram(example_isolates, antibiotics = c(aminoglycosides(), carbapenems())) antibiogram(example_isolates, antibiotics = c(\"TZP\", \"TZP+TOB\", \"TZP+GEN\"), mo_transform = \"gramstain\") antibiogram(example_isolates, antibiotics = c(\"CIP\", \"TOB\", \"GEN\"), mo_transform = \"gramstain\", ab_transform = \"name\", language = \"uk\") # Ukrainian"},{"path":"https://msberends.github.io/AMR/index.html","id":"calculating-resistance-per-group","dir":"","previous_headings":"Practical examples","what":"Calculating resistance per group","title":"Antimicrobial Resistance Data Analysis","text":"","code":"library(AMR) library(dplyr) out <- example_isolates %>% # group by ward: group_by(ward) %>% # calculate AMR using resistance(), over all aminoglycosides # and polymyxins: summarise(across(c(aminoglycosides(), polymyxins()), resistance)) out # transform the antibiotic columns to names: out %>% set_ab_names() # transform the antibiotic column to ATC codes: out %>% set_ab_names(property = \"atc\")"},{"path":"https://msberends.github.io/AMR/index.html","id":"what-else-can-you-do-with-this-package","dir":"","previous_headings":"","what":"What else can you do with this package?","title":"Antimicrobial Resistance Data Analysis","text":"package intended comprehensive toolbox integrated AMR data analysis. package can used : Reference taxonomy microorganisms, since package contains microbial (sub)species List Prokaryotic names Standing Nomenclature (LPSN) Global Biodiversity Information Facility (GBIF) (manual) Interpreting raw MIC disk diffusion values, based CLSI EUCAST guideline last 10 years (manual) Retrieving antimicrobial drug names, doses forms administration clinical health care records (manual) Determining first isolates used AMR data analysis (manual) Calculating antimicrobial resistance (tutorial) Determining multi-drug resistance (MDR) / multi-drug resistant organisms (MDRO) (tutorial) Calculating (empirical) susceptibility mono therapy combination therapies (tutorial) Predicting future antimicrobial resistance using regression models (tutorial) Getting properties microorganism (like Gram stain, species, genus family) (manual) Getting properties antibiotic (like name, code EARS-Net/ATC/LOINC/PubChem, defined daily dose trade name) (manual) Plotting antimicrobial resistance (tutorial) Applying EUCAST expert rules (manual) Getting SNOMED codes microorganism, getting properties microorganism based SNOMED code (manual) Getting LOINC codes antibiotic, getting properties antibiotic based LOINC code (manual) Machine reading EUCAST CLSI guidelines 2011-2021 translate MIC values disk diffusion diameters SIR (link) Principal component analysis AMR (tutorial)","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/index.html","id":"latest-official-version","dir":"","previous_headings":"Get this package","what":"Latest official version","title":"Antimicrobial Resistance Data Analysis","text":"package available official R network (CRAN). Install package R CRAN using command: downloaded installed automatically. RStudio, click menu Tools > Install Packages… type “AMR” press Install. Note: functions website may available latest release. use functions data sets mentioned website, install latest development version.","code":"install.packages(\"AMR\")"},{"path":"https://msberends.github.io/AMR/index.html","id":"latest-development-version","dir":"","previous_headings":"Get this package","what":"Latest development version","title":"Antimicrobial Resistance Data Analysis","text":"Please read Developer Guideline . latest unpublished development version can installed GitHub two ways: Manually, using: Automatically, using rOpenSci R-universe platform, adding R-universe address list repositories (‘repos’): , can install update AMR package like official release (e.g., using install.packages(\"AMR\") RStudio via Tools > Check Package Updates…).","code":"install.packages(\"remotes\") # if you haven't already remotes::install_github(\"msberends/AMR\") options(repos = c(getOption(\"repos\"), msberends = \"https://msberends.r-universe.dev\"))"},{"path":"https://msberends.github.io/AMR/index.html","id":"get-started","dir":"","previous_headings":"","what":"Get started","title":"Antimicrobial Resistance Data Analysis","text":"find conduct AMR data analysis, please continue reading get started click link ‘’ menu.","code":""},{"path":"https://msberends.github.io/AMR/index.html","id":"partners","dir":"","previous_headings":"","what":"Partners","title":"Antimicrobial Resistance Data Analysis","text":"development package part , related , made possible following non-profit organisations initiatives:","code":""},{"path":"https://msberends.github.io/AMR/index.html","id":"copyright","dir":"","previous_headings":"","what":"Copyright","title":"Antimicrobial Resistance Data Analysis","text":"R package free, open-source software licensed GNU General Public License v2.0 (GPL-2). nutshell, means package: May used commercial purposes May used private purposes May used patent purposes May modified, although: Modifications must released license distributing package Changes made code must documented May distributed, although: Source code must made available package distributed copy license copyright notice must included package. Comes LIMITATION liability Comes warranty","code":""},{"path":"https://msberends.github.io/AMR/reference/AMR-deprecated.html","id":null,"dir":"Reference","previous_headings":"","what":"Deprecated Functions — AMR-deprecated","title":"Deprecated Functions — AMR-deprecated","text":"functions -called 'Deprecated'. removed future release. Using functions give warning name function replaced (one).","code":""},{"path":"https://msberends.github.io/AMR/reference/AMR-deprecated.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Deprecated Functions — AMR-deprecated","text":"","code":"NA_rsi_ as.rsi(x, ...) facet_rsi(...) geom_rsi(...) ggplot_rsi(...) ggplot_rsi_predict(...) is.rsi(x, ...) is.rsi.eligible(...) labels_rsi_count(...) n_rsi(...) random_rsi(...) rsi_df(...) rsi_predict(...) scale_rsi_colours(...) theme_rsi(...)"},{"path":"https://msberends.github.io/AMR/reference/AMR-deprecated.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Deprecated Functions — AMR-deprecated","text":"object class rsi (inherits ordered, factor) length 1.","code":""},{"path":"https://msberends.github.io/AMR/reference/AMR-options.html","id":null,"dir":"Reference","previous_headings":"","what":"Options for the AMR package — AMR-options","title":"Options for the AMR package — AMR-options","text":"overview package-specific options() can set AMR package.","code":""},{"path":"https://msberends.github.io/AMR/reference/AMR-options.html","id":"options","dir":"Reference","previous_headings":"","what":"Options","title":"Options for the AMR package — AMR-options","text":"AMR_custom_ab Allows use custom antimicrobial drugs package. explained add_custom_antimicrobials(). AMR_custom_mo Allows use custom microorganisms package. explained add_custom_microorganisms(). AMR_eucastrules Used setting default types rules eucast_rules() function, must one : \"breakpoints\", \"expert\", \"\", \"custom\", \"\", defaults c(\"breakpoints\", \"expert\"). AMR_guideline Used setting default guideline interpreting MIC values disk diffusion diameters .sir(). Can guideline name (e.g., \"CLSI\") name year (e.g. \"CLSI 2019\"). default \"EUCAST 2022\". Supported guideline currently EUCAST (2013-2022) CLSI (2013-2022). AMR_ignore_pattern regular expression define input must ignored .mo() mo_* functions. AMR_include_PKPD logical use .sir(), indicate PK/PD clinical breakpoints must applied last resort, defaults TRUE. AMR_include_screening logical use .sir(), indicate clinical breakpoints screening allowed, defaults FALSE. AMR_keep_synonyms logical use .mo() mo_* functions, indicate old, previously valid taxonomic names must preserved corrected currently accepted names. AMR_locale language use AMR package, can one supported language names ISO-639-1 codes: English (en), Chinese (zh), Czech (cs), Danish (da), Dutch (nl), Finnish (fi), French (fr), German (de), Greek (el), Italian (), Japanese (ja), Norwegian (), Polish (pl), Portuguese (pt), Romanian (ro), Russian (ru), Spanish (es), Swedish (sv), Turkish (tr) Ukrainian (uk). AMR_mo_source file location manual code list used .mo() mo_* functions. explained set_mo_source().","code":""},{"path":"https://msberends.github.io/AMR/reference/AMR-options.html","id":"saving-settings-between-sessions","dir":"Reference","previous_headings":"","what":"Saving Settings Between Sessions","title":"Options for the AMR package — AMR-options","text":"Settings R saved globally thus lost R exited. can save options .Rprofile file, user-specific file. can edit using: file, can set options : add Portuguese language support antibiotics, allow PK/PD rules interpreting MIC values .sir().","code":"utils::file.edit(\"~/.Rprofile\") options(AMR_locale = \"pt\") options(AMR_include_PKPD = TRUE)"},{"path":"https://msberends.github.io/AMR/reference/AMR-options.html","id":"share-options-within-team","dir":"Reference","previous_headings":"","what":"Share Options Within Team","title":"Options for the AMR package — AMR-options","text":"global approach, e.g. within data team, save options file remote file location, shared network drive. work way: Save plain text file e.g. \"X:/team_folder/R_options.R\" fill preferred settings. user, open .Rprofile file using utils::file.edit(\"~/.Rprofile\") put : Reload R/RStudio check settings getOption(), e.g. getOption(\"AMR_locale\") set value. Now team settings configured one place, can maintained .","code":"source(\"X:/team_folder/R_options.R\")"},{"path":"https://msberends.github.io/AMR/reference/AMR.html","id":null,"dir":"Reference","previous_headings":"","what":"The AMR Package — AMR","title":"The AMR Package — AMR","text":"Welcome AMR package. AMR package free open-source R package zero dependencies simplify analysis prediction Antimicrobial Resistance (AMR) work microbial antimicrobial data properties, using evidence-based methods. aim provide standard clean reproducible AMR data analysis, can therefore empower epidemiological analyses continuously enable surveillance treatment evaluation setting. Many different researchers around globe continually helping us make successful durable project! work published Journal Statistical Software (Volume 104(3); DOI 10.18637/jss.v104.i03) formed basis two PhD theses (DOI 10.33612/diss.177417131 DOI 10.33612/diss.192486375). installing package, R knows ~52 000 (updated December 2022) ~600 antibiotic, antimycotic antiviral drugs name code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC SNOMED CT), knows valid SIR MIC values. integral breakpoint guidelines CLSI EUCAST included last 10 years. supports can read data format, including WHONET data. package works Windows, macOS Linux versions R since R-3.0 (April 2013). designed work setting, including limited resources. created routine data analysis academic research Faculty Medical Sciences University Groningen, collaboration non-profit organisations Certe Medical Diagnostics Advice Foundation University Medical Center Groningen. AMR package available English, Chinese, Danish, Dutch, French, German, Greek, Italian, Japanese, Polish, Portuguese, Russian, Spanish, Swedish, Turkish Ukrainian. Antimicrobial drug (group) names colloquial microorganism names provided languages.","code":""},{"path":"https://msberends.github.io/AMR/reference/AMR.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"The AMR Package — AMR","text":"cite AMR publications use: Berends MS, Luz CF, Friedrich AW, Sinha BNM, Albers CJ, Glasner C (2022). \"AMR: R Package Working Antimicrobial Resistance Data.\" Journal Statistical Software, 104(3), 1-31. doi:10.18637/jss.v104.i03 . BibTeX entry LaTeX users :","code":"@Article{, title = {{AMR}: An {R} Package for Working with Antimicrobial Resistance Data}, author = {Matthijs S. Berends and Christian F. Luz and Alexander W. Friedrich and Bhanu N. M. Sinha and Casper J. Albers and Corinna Glasner}, journal = {Journal of Statistical Software}, year = {2022}, volume = {104}, number = {3}, pages = {1--31}, doi = {10.18637/jss.v104.i03}, }"},{"path":"https://msberends.github.io/AMR/reference/AMR.html","id":"reference-data-publicly-available","dir":"Reference","previous_headings":"","what":"Reference Data Publicly Available","title":"The AMR Package — AMR","text":"data sets AMR package (microorganisms, antibiotics, SIR interpretation, EUCAST rules, etc.) publicly freely available download following formats: R, MS Excel, Apache Feather, Apache Parquet, SPSS, SAS, Stata. also provide tab-separated plain text files machine-readable suitable input software program, laboratory information systems. Please visit website download links. actual files course available GitHub repository.","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/reference/AMR.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"The AMR Package — AMR","text":"Maintainer: Matthijs S. Berends m.berends@certe.nl (ORCID) Authors: Christian F. Luz (ORCID) [contributor] Dennis Souverein (ORCID) [contributor] Erwin E. . Hassing [contributor] contributors: Casper J. Albers (ORCID) [thesis advisor] Peter Dutey-Magni (ORCID) [contributor] Judith M. Fonville [contributor] Alex W. Friedrich (ORCID) [thesis advisor] Corinna Glasner (ORCID) [thesis advisor] Eric H. L. C. M. Hazenberg [contributor] Gwen Knight (ORCID) [contributor] Annick Lenglet (ORCID) [contributor] Bart C. Meijer [contributor] Dmytro Mykhailenko [contributor] Anton Mymrikov [contributor] Andrew P. Norgan (ORCID) [contributor] Sofia Ny (ORCID) [contributor] Jonas Salm [contributor] Rogier P. Schade [contributor] Bhanu N. M. Sinha (ORCID) [thesis advisor] Anthony Underwood (ORCID) [contributor] Anita Williams (ORCID) [contributor]","code":""},{"path":"https://msberends.github.io/AMR/reference/WHOCC.html","id":null,"dir":"Reference","previous_headings":"","what":"WHOCC: WHO Collaborating Centre for Drug Statistics Methodology — WHOCC","title":"WHOCC: WHO Collaborating Centre for Drug Statistics Methodology — WHOCC","text":"antimicrobial drugs official names, ATC codes, ATC groups defined daily dose (DDD) included package, using Collaborating Centre Drug Statistics Methodology.","code":""},{"path":"https://msberends.github.io/AMR/reference/WHOCC.html","id":"whocc","dir":"Reference","previous_headings":"","what":"WHOCC","title":"WHOCC: WHO Collaborating Centre for Drug Statistics Methodology — WHOCC","text":"package contains ~550 antibiotic, antimycotic antiviral drugs Anatomical Therapeutic Chemical (ATC) codes, ATC groups Defined Daily Dose (DDD) World Health Organization Collaborating Centre Drug Statistics Methodology (WHOCC, https://www.whocc.) Pharmaceuticals Community Register European Commission (https://ec.europa.eu/health/documents/community-register/html/reg_hum_atc.htm). become gold standard international drug utilisation monitoring research. WHOCC located Oslo Norwegian Institute Public Health funded Norwegian government. European Commission executive European Union promotes general interest. NOTE: WHOCC copyright allow use commercial purposes, unlike info package. See https://www.whocc./copyright_disclaimer/.","code":""},{"path":"https://msberends.github.io/AMR/reference/WHOCC.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"WHOCC: WHO Collaborating Centre for Drug Statistics Methodology — WHOCC","text":"","code":"as.ab(\"meropenem\") #> Class 'ab' #> [1] MEM ab_name(\"J01DH02\") #> [1] \"Meropenem\" ab_tradenames(\"flucloxacillin\") #> [1] \"culpen\" \"floxacillin\" \"floxacillin sodium\" #> [4] \"floxapen\" \"floxapen sodium salt\" \"fluclox\" #> [7] \"flucloxacilina\" \"flucloxacillin\" \"flucloxacilline\" #> [10] \"flucloxacillinum\" \"fluorochloroxacillin\" \"staphylex\""},{"path":"https://msberends.github.io/AMR/reference/WHONET.html","id":null,"dir":"Reference","previous_headings":"","what":"Data Set with 500 Isolates - WHONET Example — WHONET","title":"Data Set with 500 Isolates - WHONET Example — WHONET","text":"example data set exact structure export file WHONET. files can used package, example data set shows. antibiotic results example_isolates data set. patient names created using online surname generators place practice purposes.","code":""},{"path":"https://msberends.github.io/AMR/reference/WHONET.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Data Set with 500 Isolates - WHONET Example — WHONET","text":"","code":"WHONET"},{"path":"https://msberends.github.io/AMR/reference/WHONET.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Data Set with 500 Isolates - WHONET Example — WHONET","text":"tibble 500 observations 53 variables: Identification number ID sample Specimen number ID specimen Organism Name microorganism. analysis, transform valid microbial class, using .mo(). Country Country origin Laboratory Name laboratory Last name Fictitious last name patient First name Fictitious initial patient Sex Fictitious gender patient Age Fictitious age patient Age category Age group, can also looked using age_groups() Date admissionDate hospital admission Specimen dateDate specimen received laboratory Specimen type Specimen type group Specimen type (Numeric) Translation \"Specimen type\" Reason Reason request Differential Diagnosis Isolate number ID isolate Organism type Type microorganism, can also looked using mo_type() Serotype Serotype microorganism Beta-lactamase Microorganism produces beta-lactamase? ESBL Microorganism produces extended spectrum beta-lactamase? Carbapenemase Microorganism produces carbapenemase? MRSA screening test Microorganism possible MRSA? Inducible clindamycin resistance Clindamycin can induced? Comment comments Date data entryDate data entered WHONET AMP_ND10:CIP_EE 0 different antibiotics. can lookup abbreviations antibiotics data set, use e.g. ab_name(\"AMP\") get official name immediately. analysis, transform valid antibiotic class, using .sir().","code":""},{"path":"https://msberends.github.io/AMR/reference/WHONET.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Data Set with 500 Isolates - WHONET Example — WHONET","text":"Like data sets package, data set publicly available download following formats: R, MS Excel, Apache Feather, Apache Parquet, SPSS, SAS, Stata. Please visit website download links. actual files course available GitHub repository.","code":""},{"path":"https://msberends.github.io/AMR/reference/WHONET.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Data Set with 500 Isolates - WHONET Example — WHONET","text":"","code":"WHONET #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> Warning: * The 'rsi' class has been replaced with 'sir'. Transform your 'rsi' #> columns to 'sir' with as.sir(), e.g.: #> your_data %>% mutate_if(is.rsi, as.sir) #> # A tibble: 500 × 53 #> Identif…¹ Speci…² Organ…³ Country Labor…⁴ Last …⁵ First…⁶ Sex Age Age c…⁷ #> #> 1 fe41d7ba… 1748 SPN Belgium Nation… Abel B. F 68 55-74 #> 2 91f175ec… 1767 eco The Ne… Nation… Delacr… F. M 89 75+ #> 3 cc401505… 1343 eco The Ne… Nation… Steens… F. M 85 75+ #> 4 e864b692… 1894 MAP Denmark Nation… Beyers… L. M 62 55-74 #> 5 3d051fe3… 1739 PVU Belgium Nation… Hummel W. M 86 75+ #> 6 c80762a0… 1846 103 The Ne… Nation… Eikenb… J. F 53 25-54 #> 7 8022d372… 1628 103 Denmark Nation… Leclerc S. F 77 75+ #> 8 f3dc5f55… 1493 eco The Ne… Nation… Delacr… W. M 53 25-54 #> 9 15add38f… 1847 eco France Nation… Van La… S. F 63 55-74 #> 10 fd41248d… 1458 eco Germany Nation… Moulin O. F 75 75+ #> # … with 490 more rows, 43 more variables: `Date of admission` , #> # `Specimen date` , `Specimen type` , #> # `Specimen type (Numeric)` , Reason , `Isolate number` , #> # `Organism type` , Serotype , `Beta-lactamase` , ESBL , #> # Carbapenemase , `MRSA screening test` , #> # `Inducible clindamycin resistance` , Comment , #> # `Date of data entry` , AMP_ND10 , AMC_ED20 , …"},{"path":"https://msberends.github.io/AMR/reference/ab_from_text.html","id":null,"dir":"Reference","previous_headings":"","what":"Retrieve Antimicrobial Drug Names and Doses from Clinical Text — ab_from_text","title":"Retrieve Antimicrobial Drug Names and Doses from Clinical Text — ab_from_text","text":"Use function e.g. clinical texts health care records. returns list antimicrobial drugs, doses forms administration found texts.","code":""},{"path":"https://msberends.github.io/AMR/reference/ab_from_text.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Retrieve Antimicrobial Drug Names and Doses from Clinical Text — ab_from_text","text":"","code":"ab_from_text( text, type = c(\"drug\", \"dose\", \"administration\"), collapse = NULL, translate_ab = FALSE, thorough_search = NULL, info = interactive(), ... )"},{"path":"https://msberends.github.io/AMR/reference/ab_from_text.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Retrieve Antimicrobial Drug Names and Doses from Clinical Text — ab_from_text","text":"text text analyse type type property search , either \"drug\", \"dose\" \"administration\", see Examples collapse character pass paste(, collapse = ...) return one character per element text, see Examples translate_ab type = \"drug\": column name antibiotics data set translate antibiotic abbreviations , using ab_property(). Defaults FALSE. Using TRUE equal using \"name\". thorough_search logical indicate whether input must extensively searched misspelling faulty input values. Setting TRUE take considerably time using FALSE. default, turn TRUE input elements contain maximum three words. info logical indicate whether progress bar printed, defaults TRUE interactive mode ... arguments passed .ab()","code":""},{"path":"https://msberends.github.io/AMR/reference/ab_from_text.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Retrieve Antimicrobial Drug Names and Doses from Clinical Text — ab_from_text","text":"list, character collapse NULL","code":""},{"path":"https://msberends.github.io/AMR/reference/ab_from_text.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Retrieve Antimicrobial Drug Names and Doses from Clinical Text — ab_from_text","text":"function also internally used .ab(), although searches first drug name throw note drug names returned. Note: .ab() function may use long regular expression match brand names antimicrobial drugs. may fail systems.","code":""},{"path":"https://msberends.github.io/AMR/reference/ab_from_text.html","id":"argument-type","dir":"Reference","previous_headings":"","what":"Argument type","title":"Retrieve Antimicrobial Drug Names and Doses from Clinical Text — ab_from_text","text":"default, function search antimicrobial drug names. text elements searched official names, ATC codes brand names. uses .ab() internally, correct misspelling. type = \"dose\" (similar, like \"dosing\", \"doses\"), text elements searched numeric values higher 100 resemble years. output numeric. supports unit (g, mg, IE, etc.) multiple values one clinical text, see Examples. type = \"administration\" (abbreviations, like \"admin\", \"adm\"), text elements searched form drug administration. supports following forms (including common abbreviations): buccal, implant, inhalation, instillation, intravenous, nasal, oral, parenteral, rectal, sublingual, transdermal vaginal. Abbreviations oral ('po', 'per os') become \"oral\", values intravenous ('iv', 'intraven') become \"iv\". supports multiple values one clinical text, see Examples.","code":""},{"path":"https://msberends.github.io/AMR/reference/ab_from_text.html","id":"argument-collapse","dir":"Reference","previous_headings":"","what":"Argument collapse","title":"Retrieve Antimicrobial Drug Names and Doses from Clinical Text — ab_from_text","text":"Without using collapse, function return list. can convenient use e.g. inside mutate()):df %>% mutate(abx = ab_from_text(clinical_text)) returned AB codes can transformed official names, groups, etc. ab_* functions ab_name() ab_group(), using translate_ab argument. using collapse, function return character:df %>% mutate(abx = ab_from_text(clinical_text, collapse = \"|\"))","code":""},{"path":"https://msberends.github.io/AMR/reference/ab_from_text.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Retrieve Antimicrobial Drug Names and Doses from Clinical Text — ab_from_text","text":"","code":"# mind the bad spelling of amoxicillin in this line, # straight from a true health care record: ab_from_text(\"28/03/2020 regular amoxicilliin 500mg po tid\") #> [[1]] #> Class 'ab' #> [1] AMX #> ab_from_text(\"500 mg amoxi po and 400mg cipro iv\") #> [[1]] #> Class 'ab' #> [1] AMX CIP #> ab_from_text(\"500 mg amoxi po and 400mg cipro iv\", type = \"dose\") #> [[1]] #> [1] 500 400 #> ab_from_text(\"500 mg amoxi po and 400mg cipro iv\", type = \"admin\") #> [[1]] #> [1] \"oral\" \"iv\" #> ab_from_text(\"500 mg amoxi po and 400mg cipro iv\", collapse = \", \") #> [1] \"AMX, CIP\" # \\donttest{ # if you want to know which antibiotic groups were administered, do e.g.: abx <- ab_from_text(\"500 mg amoxi po and 400mg cipro iv\") ab_group(abx[[1]]) #> [1] \"Beta-lactams/penicillins\" \"Quinolones\" if (require(\"dplyr\")) { tibble(clinical_text = c( \"given 400mg cipro and 500 mg amox\", \"started on doxy iv today\" )) %>% mutate( abx_codes = ab_from_text(clinical_text), abx_doses = ab_from_text(clinical_text, type = \"doses\"), abx_admin = ab_from_text(clinical_text, type = \"admin\"), abx_coll = ab_from_text(clinical_text, collapse = \"|\"), abx_coll_names = ab_from_text(clinical_text, collapse = \"|\", translate_ab = \"name\" ), abx_coll_doses = ab_from_text(clinical_text, type = \"doses\", collapse = \"|\" ), abx_coll_admin = ab_from_text(clinical_text, type = \"admin\", collapse = \"|\" ) ) } #> Loading required package: dplyr #> #> Attaching package: ‘dplyr’ #> The following objects are masked from ‘package:stats’: #> #> filter, lag #> The following objects are masked from ‘package:base’: #> #> intersect, setdiff, setequal, union #> # A tibble: 2 × 8 #> clinical_text abx_c…¹ abx_d…² abx_a…³ abx_c…⁴ abx_c…⁵ abx_c…⁶ abx_c…⁷ #> #> 1 given 400mg cipro and… CIP|AMX Ciprof… 400|500 NA #> 2 started on doxy iv to… DOX Doxycy… NA iv #> # … with abbreviated variable names ¹abx_codes, ²abx_doses, ³abx_admin, #> # ⁴abx_coll, ⁵abx_coll_names, ⁶abx_coll_doses, ⁷abx_coll_admin # }"},{"path":"https://msberends.github.io/AMR/reference/ab_property.html","id":null,"dir":"Reference","previous_headings":"","what":"Get Properties of an Antibiotic — ab_property","title":"Get Properties of an Antibiotic — ab_property","text":"Use functions return specific property antibiotic antibiotics data set. input values evaluated internally .ab().","code":""},{"path":"https://msberends.github.io/AMR/reference/ab_property.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Get Properties of an Antibiotic — ab_property","text":"","code":"ab_name(x, language = get_AMR_locale(), tolower = FALSE, ...) ab_cid(x, ...) ab_synonyms(x, ...) ab_tradenames(x, ...) ab_group(x, language = get_AMR_locale(), ...) ab_atc(x, only_first = FALSE, ...) ab_atc_group1(x, language = get_AMR_locale(), ...) ab_atc_group2(x, language = get_AMR_locale(), ...) ab_loinc(x, ...) ab_ddd(x, administration = \"oral\", ...) ab_ddd_units(x, administration = \"oral\", ...) ab_info(x, language = get_AMR_locale(), ...) ab_url(x, open = FALSE, ...) ab_property(x, property = \"name\", language = get_AMR_locale(), ...) set_ab_names( data, ..., property = \"name\", language = get_AMR_locale(), snake_case = NULL )"},{"path":"https://msberends.github.io/AMR/reference/ab_property.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Get Properties of an Antibiotic — ab_property","text":"x (vector ) text can coerced valid antibiotic drug code .ab() language language returned text, defaults system language (see get_AMR_locale()) can also set option AMR_locale. Use language = NULL language = \"\" prevent translation. tolower logical indicate whether first character every output transformed lower case character. lead e.g. \"polymyxin B\" \"polymyxin b\". ... case set_ab_names() data data.frame: columns select (supports tidy selection column1:column4), otherwise arguments passed .ab() only_first logical indicate whether first ATC code must returned, giving preference J0-codes (.e., antimicrobial drug group) administration way administration, either \"oral\" \"iv\" open browse URL using utils::browseURL() property one column names one antibiotics data set: vector_or(colnames(antibiotics), sort = FALSE). data data.frame columns need renamed, character vector column names snake_case logical indicate whether names -called snake case: lower case spaces/slashes replaced underscore (_)","code":""},{"path":"https://msberends.github.io/AMR/reference/ab_property.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Get Properties of an Antibiotic — ab_property","text":"integer case ab_cid() named list case ab_info() multiple ab_atc()/ab_synonyms()/ab_tradenames() double case ab_ddd() data.frame case set_ab_names() character cases","code":""},{"path":"https://msberends.github.io/AMR/reference/ab_property.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Get Properties of an Antibiotic — ab_property","text":"output translated possible. function ab_url() return direct URL official website. warning returned required ATC code available. function set_ab_names() special column renaming function data.frames. renames columns names resemble antimicrobial drugs. always makes sure new column names unique. property = \"atc\" set, preference given ATC codes J-group.","code":""},{"path":"https://msberends.github.io/AMR/reference/ab_property.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"Get Properties of an Antibiotic — ab_property","text":"World Health Organization () Collaborating Centre Drug Statistics Methodology: https://www.whocc./atc_ddd_index/ European Commission Public Health PHARMACEUTICALS - COMMUNITY REGISTER: https://ec.europa.eu/health/documents/community-register/html/reg_hum_atc.htm","code":""},{"path":"https://msberends.github.io/AMR/reference/ab_property.html","id":"reference-data-publicly-available","dir":"Reference","previous_headings":"","what":"Reference Data Publicly Available","title":"Get Properties of an Antibiotic — ab_property","text":"data sets AMR package (microorganisms, antibiotics, SIR interpretation, EUCAST rules, etc.) publicly freely available download following formats: R, MS Excel, Apache Feather, Apache Parquet, SPSS, SAS, Stata. also provide tab-separated plain text files machine-readable suitable input software program, laboratory information systems. Please visit website download links. actual files course available GitHub repository.","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/reference/ab_property.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Get Properties of an Antibiotic — ab_property","text":"","code":"# all properties: ab_name(\"AMX\") #> [1] \"Amoxicillin\" ab_atc(\"AMX\") #> [1] \"J01CA04\" ab_cid(\"AMX\") #> [1] 33613 ab_synonyms(\"AMX\") #> [1] \"actimoxi\" \"amoclen\" \"amolin\" #> [4] \"amopen\" \"amopenixin\" \"amoxibiotic\" #> [7] \"amoxicaps\" \"amoxicilina\" \"amoxicillin\" #> [10] \"amoxicillin hydrate\" \"amoxicilline\" \"amoxicillinum\" #> [13] \"amoxiden\" \"amoxil\" \"amoxivet\" #> [16] \"amoxy\" \"amoxycillin\" \"amoxyke\" #> [19] \"anemolin\" \"aspenil\" \"atoksilin\" #> [22] \"biomox\" \"bristamox\" \"cemoxin\" #> [25] \"clamoxyl\" \"damoxy\" \"delacillin\" #> [28] \"demoksil\" \"dispermox\" \"efpenix\" #> [31] \"flemoxin\" \"hiconcil\" \"histocillin\" #> [34] \"hydroxyampicillin\" \"ibiamox\" \"imacillin\" #> [37] \"lamoxy\" \"largopen\" \"metafarma capsules\" #> [40] \"metifarma capsules\" \"moksilin\" \"moxacin\" #> [43] \"moxatag\" \"ospamox\" \"pamoxicillin\" #> [46] \"piramox\" \"promoxil\" \"remoxil\" #> [49] \"robamox\" \"sawamox pm\" \"tolodina\" #> [52] \"topramoxin\" \"unicillin\" \"utimox\" #> [55] \"vetramox\" ab_tradenames(\"AMX\") #> [1] \"actimoxi\" \"amoclen\" \"amolin\" #> [4] \"amopen\" \"amopenixin\" \"amoxibiotic\" #> [7] \"amoxicaps\" \"amoxicilina\" \"amoxicillin\" #> [10] \"amoxicillin hydrate\" \"amoxicilline\" \"amoxicillinum\" #> [13] \"amoxiden\" \"amoxil\" \"amoxivet\" #> [16] \"amoxy\" \"amoxycillin\" \"amoxyke\" #> [19] \"anemolin\" \"aspenil\" \"atoksilin\" #> [22] \"biomox\" \"bristamox\" \"cemoxin\" #> [25] \"clamoxyl\" \"damoxy\" \"delacillin\" #> [28] \"demoksil\" \"dispermox\" \"efpenix\" #> [31] \"flemoxin\" \"hiconcil\" \"histocillin\" #> [34] \"hydroxyampicillin\" \"ibiamox\" \"imacillin\" #> [37] \"lamoxy\" \"largopen\" \"metafarma capsules\" #> [40] \"metifarma capsules\" \"moksilin\" \"moxacin\" #> [43] \"moxatag\" \"ospamox\" \"pamoxicillin\" #> [46] \"piramox\" \"promoxil\" \"remoxil\" #> [49] \"robamox\" \"sawamox pm\" \"tolodina\" #> [52] \"topramoxin\" \"unicillin\" \"utimox\" #> [55] \"vetramox\" ab_group(\"AMX\") #> [1] \"Beta-lactams/penicillins\" ab_atc_group1(\"AMX\") #> [1] \"Beta-lactam antibacterials, penicillins\" ab_atc_group2(\"AMX\") #> [1] \"Penicillins with extended spectrum\" ab_url(\"AMX\") #> Amoxicillin #> \"https://www.whocc.no/atc_ddd_index/?code=J01CA04&showdescription=no\" # smart lowercase tranformation ab_name(x = c(\"AMC\", \"PLB\")) #> [1] \"Amoxicillin/clavulanic acid\" \"Polymyxin B\" ab_name(x = c(\"AMC\", \"PLB\"), tolower = TRUE) #> [1] \"amoxicillin/clavulanic acid\" \"polymyxin B\" # defined daily doses (DDD) ab_ddd(\"AMX\", \"oral\") #> [1] 1.5 ab_ddd_units(\"AMX\", \"oral\") #> [1] \"g\" ab_ddd(\"AMX\", \"iv\") #> [1] 3 ab_ddd_units(\"AMX\", \"iv\") #> [1] \"g\" ab_info(\"AMX\") # all properties as a list #> $ab #> [1] \"AMX\" #> #> $cid #> [1] 33613 #> #> $name #> [1] \"Amoxicillin\" #> #> $group #> [1] \"Beta-lactams/penicillins\" #> #> $atc #> [1] \"J01CA04\" #> #> $atc_group1 #> [1] \"Beta-lactam antibacterials, penicillins\" #> #> $atc_group2 #> [1] \"Penicillins with extended spectrum\" #> #> $tradenames #> [1] \"actimoxi\" \"amoclen\" \"amolin\" #> [4] \"amopen\" \"amopenixin\" \"amoxibiotic\" #> [7] \"amoxicaps\" \"amoxicilina\" \"amoxicillin\" #> [10] \"amoxicillin hydrate\" \"amoxicilline\" \"amoxicillinum\" #> [13] \"amoxiden\" \"amoxil\" \"amoxivet\" #> [16] \"amoxy\" \"amoxycillin\" \"amoxyke\" #> [19] \"anemolin\" \"aspenil\" \"atoksilin\" #> [22] \"biomox\" \"bristamox\" \"cemoxin\" #> [25] \"clamoxyl\" \"damoxy\" \"delacillin\" #> [28] \"demoksil\" \"dispermox\" \"efpenix\" #> [31] \"flemoxin\" \"hiconcil\" \"histocillin\" #> [34] \"hydroxyampicillin\" \"ibiamox\" \"imacillin\" #> [37] \"lamoxy\" \"largopen\" \"metafarma capsules\" #> [40] \"metifarma capsules\" \"moksilin\" \"moxacin\" #> [43] \"moxatag\" \"ospamox\" \"pamoxicillin\" #> [46] \"piramox\" \"promoxil\" \"remoxil\" #> [49] \"robamox\" \"sawamox pm\" \"tolodina\" #> [52] \"topramoxin\" \"unicillin\" \"utimox\" #> [55] \"vetramox\" #> #> $loinc #> [1] \"16365-9\" \"25274-2\" \"3344-9\" \"80133-2\" #> #> $ddd #> $ddd$oral #> $ddd$oral$amount #> [1] 1.5 #> #> $ddd$oral$units #> [1] \"g\" #> #> #> $ddd$iv #> $ddd$iv$amount #> [1] 3 #> #> $ddd$iv$units #> [1] \"g\" #> #> #> # all ab_* functions use as.ab() internally, so you can go from 'any' to 'any': ab_atc(\"AMP\") #> [1] \"J01CA01\" \"S01AA19\" ab_group(\"J01CA01\") #> [1] \"Beta-lactams/penicillins\" ab_loinc(\"ampicillin\") #> [1] \"21066-6\" \"3355-5\" \"33562-0\" \"33919-2\" \"43883-8\" \"43884-6\" \"87604-5\" ab_name(\"21066-6\") #> [1] \"Ampicillin\" ab_name(6249) #> [1] \"Ampicillin\" ab_name(\"J01CA01\") #> [1] \"Ampicillin\" # spelling from different languages and dyslexia are no problem ab_atc(\"ceftriaxon\") #> [1] \"J01DD04\" ab_atc(\"cephtriaxone\") #> [1] \"J01DD04\" ab_atc(\"cephthriaxone\") #> [1] \"J01DD04\" ab_atc(\"seephthriaaksone\") #> [1] \"J01DD04\" # use set_ab_names() for renaming columns colnames(example_isolates) #> [1] \"date\" \"patient\" \"age\" \"gender\" \"ward\" \"mo\" \"PEN\" #> [8] \"OXA\" \"FLC\" \"AMX\" \"AMC\" \"AMP\" \"TZP\" \"CZO\" #> [15] \"FEP\" \"CXM\" \"FOX\" \"CTX\" \"CAZ\" \"CRO\" \"GEN\" #> [22] \"TOB\" \"AMK\" \"KAN\" \"TMP\" \"SXT\" \"NIT\" \"FOS\" #> [29] \"LNZ\" \"CIP\" \"MFX\" \"VAN\" \"TEC\" \"TCY\" \"TGC\" #> [36] \"DOX\" \"ERY\" \"CLI\" \"AZM\" \"IPM\" \"MEM\" \"MTR\" #> [43] \"CHL\" \"COL\" \"MUP\" \"RIF\" colnames(set_ab_names(example_isolates)) #> [1] \"date\" \"patient\" #> [3] \"age\" \"gender\" #> [5] \"ward\" \"mo\" #> [7] \"benzylpenicillin\" \"oxacillin\" #> [9] \"flucloxacillin\" \"amoxicillin\" #> [11] \"amoxicillin_clavulanic_acid\" \"ampicillin\" #> [13] \"piperacillin_tazobactam\" \"cefazolin\" #> [15] \"cefepime\" \"cefuroxime\" #> [17] \"cefoxitin\" \"cefotaxime\" #> [19] \"ceftazidime\" \"ceftriaxone\" #> [21] \"gentamicin\" \"tobramycin\" #> [23] \"amikacin\" \"kanamycin\" #> [25] \"trimethoprim\" \"trimethoprim_sulfamethoxazole\" #> [27] \"nitrofurantoin\" \"fosfomycin\" #> [29] \"linezolid\" \"ciprofloxacin\" #> [31] \"moxifloxacin\" \"vancomycin\" #> [33] \"teicoplanin\" \"tetracycline\" #> [35] \"tigecycline\" \"doxycycline\" #> [37] \"erythromycin\" \"clindamycin\" #> [39] \"azithromycin\" \"imipenem\" #> [41] \"meropenem\" \"metronidazole\" #> [43] \"chloramphenicol\" \"colistin\" #> [45] \"mupirocin\" \"rifampicin\" colnames(set_ab_names(example_isolates, NIT:VAN)) #> [1] \"date\" \"patient\" \"age\" \"gender\" #> [5] \"ward\" \"mo\" \"PEN\" \"OXA\" #> [9] \"FLC\" \"AMX\" \"AMC\" \"AMP\" #> [13] \"TZP\" \"CZO\" \"FEP\" \"CXM\" #> [17] \"FOX\" \"CTX\" \"CAZ\" \"CRO\" #> [21] \"GEN\" \"TOB\" \"AMK\" \"KAN\" #> [25] \"TMP\" \"SXT\" \"nitrofurantoin\" \"fosfomycin\" #> [29] \"linezolid\" \"ciprofloxacin\" \"moxifloxacin\" \"vancomycin\" #> [33] \"TEC\" \"TCY\" \"TGC\" \"DOX\" #> [37] \"ERY\" \"CLI\" \"AZM\" \"IPM\" #> [41] \"MEM\" \"MTR\" \"CHL\" \"COL\" #> [45] \"MUP\" \"RIF\" # \\donttest{ if (require(\"dplyr\")) { example_isolates %>% set_ab_names() # this does the same: example_isolates %>% rename_with(set_ab_names) # set_ab_names() works with any AB property: example_isolates %>% set_ab_names(property = \"atc\") example_isolates %>% set_ab_names(where(is.sir)) %>% colnames() example_isolates %>% set_ab_names(NIT:VAN) %>% colnames() } #> [1] \"date\" \"patient\" \"age\" \"gender\" #> [5] \"ward\" \"mo\" \"PEN\" \"OXA\" #> [9] \"FLC\" \"AMX\" \"AMC\" \"AMP\" #> [13] \"TZP\" \"CZO\" \"FEP\" \"CXM\" #> [17] \"FOX\" \"CTX\" \"CAZ\" \"CRO\" #> [21] \"GEN\" \"TOB\" \"AMK\" \"KAN\" #> [25] \"TMP\" \"SXT\" \"nitrofurantoin\" \"fosfomycin\" #> [29] \"linezolid\" \"ciprofloxacin\" \"moxifloxacin\" \"vancomycin\" #> [33] \"TEC\" \"TCY\" \"TGC\" \"DOX\" #> [37] \"ERY\" \"CLI\" \"AZM\" \"IPM\" #> [41] \"MEM\" \"MTR\" \"CHL\" \"COL\" #> [45] \"MUP\" \"RIF\" # }"},{"path":"https://msberends.github.io/AMR/reference/add_custom_antimicrobials.html","id":null,"dir":"Reference","previous_headings":"","what":"Add Custom Antimicrobials — add_custom_antimicrobials","title":"Add Custom Antimicrobials — add_custom_antimicrobials","text":"add_custom_antimicrobials() can add custom antimicrobial drug names codes.","code":""},{"path":"https://msberends.github.io/AMR/reference/add_custom_antimicrobials.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Add Custom Antimicrobials — add_custom_antimicrobials","text":"","code":"add_custom_antimicrobials(x) clear_custom_antimicrobials()"},{"path":"https://msberends.github.io/AMR/reference/add_custom_antimicrobials.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Add Custom Antimicrobials — add_custom_antimicrobials","text":"x data.frame resembling antibiotics data set, least containing columns \"ab\" \"name\"","code":""},{"path":"https://msberends.github.io/AMR/reference/add_custom_antimicrobials.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Add Custom Antimicrobials — add_custom_antimicrobials","text":"Important: Due R works, add_custom_antimicrobials() function run every R session - added antimicrobials stored sessions thus lost R exited. two ways automate process: Method 1: Using option AMR_custom_ab, preferred method. use method: Create data set structure antibiotics data set (containing least columns \"ab\" \"name\") save saveRDS() location choice, e.g. \"~/my_custom_ab.rds\", remote location. Set file location option AMR_custom_ab: options(AMR_custom_ab = \"~/my_custom_ab.rds\"). can even remote file location, https URL. Since options saved R sessions, best save option .Rprofile file loaded start-R. , open .Rprofile file using e.g. utils::file.edit(\"~/.Rprofile\"), add text save file: Upon package load, file loaded run add_custom_antimicrobials() function. Method 2: Loading antimicrobial additions directly .Rprofile file. important downside requires AMR package installed else method fail. use method: Edit .Rprofile file using e.g. utils::file.edit(\"~/.Rprofile\"). Add text like save file: Use clear_custom_antimicrobials() clear previously added antimicrobials.","code":"# Add custom antimicrobial codes: options(AMR_custom_ab = \"~/my_custom_ab.rds\") # Add custom antibiotic drug codes: AMR::add_custom_antimicrobials( data.frame(ab = \"TESTAB\", name = \"Test Antibiotic\", group = \"Test Group\") )"},{"path":[]},{"path":"https://msberends.github.io/AMR/reference/add_custom_antimicrobials.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Add Custom Antimicrobials — add_custom_antimicrobials","text":"","code":"# \\donttest{ # returns NA and throws a warning (which is suppressed here): suppressWarnings( as.ab(\"testab\") ) #> Class 'ab' #> [1] # now add a custom entry - it will be considered by as.ab() and # all ab_*() functions add_custom_antimicrobials( data.frame( ab = \"TESTAB\", name = \"Test Antibiotic\", # you can add any property present in the # 'antibiotics' data set, such as 'group': group = \"Test Group\" ) ) #> ℹ Added one record to the internal antibiotics data set. # \"testab\" is now a new antibiotic: as.ab(\"testab\") #> Class 'ab' #> [1] TESTAB ab_name(\"testab\") #> [1] \"Test Antibiotic\" ab_group(\"testab\") #> [1] \"Test Group\" ab_info(\"testab\") #> $ab #> [1] \"TESTAB\" #> #> $cid #> [1] NA #> #> $name #> [1] \"Test Antibiotic\" #> #> $group #> [1] \"Test Group\" #> #> $atc #> [1] NA #> #> $atc_group1 #> [1] NA #> #> $atc_group2 #> [1] NA #> #> $tradenames #> [1] NA #> #> $loinc #> [1] NA #> #> $ddd #> $ddd$oral #> $ddd$oral$amount #> [1] NA #> #> $ddd$oral$units #> [1] NA #> #> #> $ddd$iv #> $ddd$iv$amount #> [1] NA #> #> $ddd$iv$units #> [1] NA #> #> #> # Add Co-fluampicil, which is one of the many J01CR50 codes, see # https://www.whocc.no/ddd/list_of_ddds_combined_products/ add_custom_antimicrobials( data.frame( ab = \"COFLU\", name = \"Co-fluampicil\", atc = \"J01CR50\", group = \"Beta-lactams/penicillins\" ) ) #> ℹ Added one record to the internal antibiotics data set. ab_atc(\"Co-fluampicil\") #> [1] \"J01CR50\" ab_name(\"J01CR50\") #> [1] \"Co-fluampicil\" # even antibiotic selectors work x <- data.frame( random_column = \"some value\", coflu = as.sir(\"S\"), ampicillin = as.sir(\"R\") ) x #> random_column coflu ampicillin #> 1 some value S R x[, betalactams()] #> ℹ For betalactams() using columns 'coflu' (co-fluampicil) and #> 'ampicillin' #> coflu ampicillin #> 1 S R # }"},{"path":"https://msberends.github.io/AMR/reference/add_custom_microorganisms.html","id":null,"dir":"Reference","previous_headings":"","what":"Add Custom Microorganisms — add_custom_microorganisms","title":"Add Custom Microorganisms — add_custom_microorganisms","text":"add_custom_microorganisms() can add custom microorganisms, non-taxonomic outcome laboratory analysis.","code":""},{"path":"https://msberends.github.io/AMR/reference/add_custom_microorganisms.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Add Custom Microorganisms — add_custom_microorganisms","text":"","code":"add_custom_microorganisms(x) clear_custom_microorganisms()"},{"path":"https://msberends.github.io/AMR/reference/add_custom_microorganisms.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Add Custom Microorganisms — add_custom_microorganisms","text":"x data.frame resembling microorganisms data set, least containing column \"genus\" (case-insensitive)","code":""},{"path":"https://msberends.github.io/AMR/reference/add_custom_microorganisms.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Add Custom Microorganisms — add_custom_microorganisms","text":"function fill missing taxonomy , specific taxonomic columns missing, see Examples. Important: Due R works, add_custom_microorganisms() function run every R session - added microorganisms stored sessions thus lost R exited. two ways automate process: Method 1: Using option AMR_custom_mo, preferred method. use method: Create data set structure microorganisms data set (containing least column \"genus\") save saveRDS() location choice, e.g. \"~/my_custom_mo.rds\", remote location. Set file location option AMR_custom_mo: options(AMR_custom_mo = \"~/my_custom_mo.rds\"). can even remote file location, https URL. Since options saved R sessions, best save option .Rprofile file loaded start-R. , open .Rprofile file using e.g. utils::file.edit(\"~/.Rprofile\"), add text save file: Upon package load, file loaded run add_custom_microorganisms() function. Method 2: Loading microorganism directly .Rprofile file. important downside requires AMR package installed else method fail. use method: Edit .Rprofile file using e.g. utils::file.edit(\"~/.Rprofile\"). Add text like save file: Use clear_custom_microorganisms() clear previously added antimicrobials.","code":"# Add custom microorganism codes: options(AMR_custom_mo = \"~/my_custom_mo.rds\") # Add custom antibiotic drug codes: AMR::add_custom_microorganisms( data.frame(genus = \"Enterobacter\", species = \"asburiae/cloacae\") )"},{"path":[]},{"path":"https://msberends.github.io/AMR/reference/add_custom_microorganisms.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Add Custom Microorganisms — add_custom_microorganisms","text":"","code":"# \\donttest{ # a combination of species is not formal taxonomy, so # this will result in only \"Enterobacter asburiae\": mo_name(\"Enterobacter asburiae/cloacae\") #> [1] \"Enterobacter asburiae\" # now add a custom entry - it will be considered by as.mo() and # all mo_*() functions add_custom_microorganisms( data.frame( genus = \"Enterobacter\", species = \"asburiae/cloacae\" ) ) #> ℹ Added Enterobacter asburiae/cloacae to the internal microorganisms data #> set. # E. asburiae/cloacae is now a new microorganism: mo_name(\"Enterobacter asburiae/cloacae\") #> [1] \"Enterobacter asburiae/cloacae\" # its code: as.mo(\"Enterobacter asburiae/cloacae\") #> Class 'mo' #> [1] CUSTOM1_ENTRBC_A_C # all internal algorithms will work as well: mo_name(\"Ent asburia cloacae\") #> [1] \"Enterobacter asburiae/cloacae\" # and even the taxonomy was added based on the genus! mo_family(\"E. asburiae/cloacae\") #> [1] \"Enterobacteriaceae\" mo_gramstain(\"Enterobacter asburiae/cloacae\") #> [1] \"Gram-negative\" mo_info(\"Enterobacter asburiae/cloacae\") #> $mo #> [1] \"CUSTOM1_ENTRBC_A_C\" #> #> $kingdom #> [1] \"Bacteria\" #> #> $phylum #> [1] \"Pseudomonadota\" #> #> $class #> [1] \"Gammaproteobacteria\" #> #> $order #> [1] \"Enterobacterales\" #> #> $family #> [1] \"Enterobacteriaceae\" #> #> $genus #> [1] \"Enterobacter\" #> #> $species #> [1] \"asburiae/cloacae\" #> #> $subspecies #> [1] \"\" #> #> $status #> [1] \"accepted\" #> #> $synonyms #> NULL #> #> $gramstain #> [1] \"Gram-negative\" #> #> $url #> [1] \"\" #> #> $ref #> [1] \"Self-added, 2023\" #> #> $snomed #> [1] NA #> # the function tries to be forgiving: add_custom_microorganisms( data.frame( GENUS = \"BACTEROIDES / PARABACTEROIDES SLASHLINE\", SPECIES = \"SPECIES\" ) ) #> ℹ Added Bacteroides/Parabacteroides to the internal microorganisms data #> set. mo_name(\"BACTEROIDES / PARABACTEROIDES\") #> [1] \"Bacteroides/Parabacteroides\" mo_rank(\"BACTEROIDES / PARABACTEROIDES\") #> [1] \"genus\" # taxonomy still works, although a slashline genus was given as input: mo_family(\"Bacteroides/Parabacteroides\") #> [1] \"Bacteroidaceae\" # for groups and complexes, set them as species or subspecies: add_custom_microorganisms( data.frame( genus = \"Citrobacter\", species = c(\"freundii\", \"braakii complex\"), subspecies = c(\"complex\", \"\") ) ) #> ℹ Added Citrobacter braakii complex and Citrobacter freundii complex to the #> internal microorganisms data set. mo_name(c(\"C. freundii complex\", \"C. braakii complex\")) #> [1] \"Citrobacter freundii complex\" \"Citrobacter braakii complex\" mo_species(c(\"C. freundii complex\", \"C. braakii complex\")) #> [1] \"freundii complex\" \"braakii complex\" mo_gramstain(c(\"C. freundii complex\", \"C. braakii complex\")) #> [1] \"Gram-negative\" \"Gram-negative\" # }"},{"path":"https://msberends.github.io/AMR/reference/age.html","id":null,"dir":"Reference","previous_headings":"","what":"Age in Years of Individuals — age","title":"Age in Years of Individuals — age","text":"Calculates age years based reference date, system date default.","code":""},{"path":"https://msberends.github.io/AMR/reference/age.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Age in Years of Individuals — age","text":"","code":"age(x, reference = Sys.Date(), exact = FALSE, na.rm = FALSE, ...)"},{"path":"https://msberends.github.io/AMR/reference/age.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Age in Years of Individuals — age","text":"x date(s), character (vectors) coerced .POSIXlt() reference reference date(s) (defaults today), character (vectors) coerced .POSIXlt() exact logical indicate whether age calculation exact, .e. decimals. divides number days year--date (YTD) x number days year reference (either 365 366). na.rm logical indicate whether missing values removed ... arguments passed .POSIXlt(), origin","code":""},{"path":"https://msberends.github.io/AMR/reference/age.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Age in Years of Individuals — age","text":"integer (decimals) exact = FALSE, double (decimals) otherwise","code":""},{"path":"https://msberends.github.io/AMR/reference/age.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Age in Years of Individuals — age","text":"Ages 0 returned NA warning. Ages 120 give warning. function vectorises x reference, meaning either can length 1 argument larger length.","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/reference/age.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Age in Years of Individuals — age","text":"","code":"# 10 random pre-Y2K birth dates df <- data.frame(birth_date = as.Date(\"2000-01-01\") - runif(10) * 25000) # add ages df$age <- age(df$birth_date) # add exact ages df$age_exact <- age(df$birth_date, exact = TRUE) # add age at millenium switch df$age_at_y2k <- age(df$birth_date, \"2000-01-01\") df #> birth_date age age_exact age_at_y2k #> 1 1999-05-08 23 23.77534 0 #> 2 1956-01-15 67 67.08493 43 #> 3 1938-07-04 84 84.61918 61 #> 4 1986-09-26 36 36.38904 13 #> 5 1951-07-28 71 71.55342 48 #> 6 1988-10-29 34 34.29863 11 #> 7 1980-10-10 42 42.35068 19 #> 8 1964-01-25 59 59.05753 35 #> 9 1947-04-26 75 75.80822 52 #> 10 1991-06-27 31 31.63836 8"},{"path":"https://msberends.github.io/AMR/reference/age_groups.html","id":null,"dir":"Reference","previous_headings":"","what":"Split Ages into Age Groups — age_groups","title":"Split Ages into Age Groups — age_groups","text":"Split ages age groups defined split argument. allows easier demographic (antimicrobial resistance) analysis.","code":""},{"path":"https://msberends.github.io/AMR/reference/age_groups.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Split Ages into Age Groups — age_groups","text":"","code":"age_groups(x, split_at = c(12, 25, 55, 75), na.rm = FALSE)"},{"path":"https://msberends.github.io/AMR/reference/age_groups.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Split Ages into Age Groups — age_groups","text":"x age, e.g. calculated age() split_at values split x , defaults age groups 0-11, 12-24, 25-54, 55-74 75+. See Details. na.rm logical indicate whether missing values removed","code":""},{"path":"https://msberends.github.io/AMR/reference/age_groups.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Split Ages into Age Groups — age_groups","text":"Ordered factor","code":""},{"path":"https://msberends.github.io/AMR/reference/age_groups.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Split Ages into Age Groups — age_groups","text":"split ages, input split_at argument can : numeric vector. value e.g. c(10, 20) split x 0-9, 10-19 20+. value 50 split x 0-49 50+. default split young children (0-11), youth (12-24), young adults (25-54), middle-aged adults (55-74) elderly (75+). character: \"children\" \"kids\", equivalent : c(0, 1, 2, 4, 6, 13, 18). split 0, 1, 2-3, 4-5, 6-12, 13-17 18+. \"elderly\" \"seniors\", equivalent : c(65, 75, 85). split 0-64, 65-74, 75-84, 85+. \"fives\", equivalent : 1:20 * 5. split 0-4, 5-9, ..., 95-99, 100+. \"tens\", equivalent : 1:10 * 10. split 0-9, 10-19, ..., 90-99, 100+.","code":""},{"path":[]},{"path":"https://msberends.github.io/AMR/reference/age_groups.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Split Ages into Age Groups — age_groups","text":"","code":"ages <- c(3, 8, 16, 54, 31, 76, 101, 43, 21) # split into 0-49 and 50+ age_groups(ages, 50) #> [1] 0-49 0-49 0-49 50+ 0-49 50+ 50+ 0-49 0-49 #> Levels: 0-49 < 50+ # split into 0-19, 20-49 and 50+ age_groups(ages, c(20, 50)) #> [1] 0-19 0-19 0-19 50+ 20-49 50+ 50+ 20-49 20-49 #> Levels: 0-19 < 20-49 < 50+ # split into groups of ten years age_groups(ages, 1:10 * 10) #> [1] 0-9 0-9 10-19 50-59 30-39 70-79 100+ 40-49 20-29 #> 11 Levels: 0-9 < 10-19 < 20-29 < 30-39 < 40-49 < 50-59 < 60-69 < ... < 100+ age_groups(ages, split_at = \"tens\") #> [1] 0-9 0-9 10-19 50-59 30-39 70-79 100+ 40-49 20-29 #> 11 Levels: 0-9 < 10-19 < 20-29 < 30-39 < 40-49 < 50-59 < 60-69 < ... < 100+ # split into groups of five years age_groups(ages, 1:20 * 5) #> [1] 0-4 5-9 15-19 50-54 30-34 75-79 100+ 40-44 20-24 #> 21 Levels: 0-4 < 5-9 < 10-14 < 15-19 < 20-24 < 25-29 < 30-34 < ... < 100+ age_groups(ages, split_at = \"fives\") #> [1] 0-4 5-9 15-19 50-54 30-34 75-79 100+ 40-44 20-24 #> 21 Levels: 0-4 < 5-9 < 10-14 < 15-19 < 20-24 < 25-29 < 30-34 < ... < 100+ # split specifically for children age_groups(ages, c(1, 2, 4, 6, 13, 18)) #> [1] 2-3 6-12 13-17 18+ 18+ 18+ 18+ 18+ 18+ #> Levels: 0 < 1 < 2-3 < 4-5 < 6-12 < 13-17 < 18+ age_groups(ages, \"children\") #> [1] 2-3 6-12 13-17 18+ 18+ 18+ 18+ 18+ 18+ #> Levels: 0 < 1 < 2-3 < 4-5 < 6-12 < 13-17 < 18+ # \\donttest{ # resistance of ciprofloxacin per age group if (require(\"dplyr\") && require(\"ggplot2\")) { example_isolates %>% filter_first_isolate() %>% filter(mo == as.mo(\"Escherichia coli\")) %>% group_by(age_group = age_groups(age)) %>% select(age_group, CIP) %>% ggplot_sir( x = \"age_group\", minimum = 0, x.title = \"Age Group\", title = \"Ciprofloxacin resistance per age group\" ) } #> Loading required package: ggplot2 # }"},{"path":"https://msberends.github.io/AMR/reference/antibiogram.html","id":null,"dir":"Reference","previous_headings":"","what":"Generate Antibiogram: Traditional, Combined, Syndromic, or Weighted-Incidence Syndromic Combination (WISCA) — antibiogram","title":"Generate Antibiogram: Traditional, Combined, Syndromic, or Weighted-Incidence Syndromic Combination (WISCA) — antibiogram","text":"Generate antibiogram, communicate results plots tables. functions follow logic Klinker et al. Barbieri et al. (see Source), allow reporting e.g. R Markdown Quarto well.","code":""},{"path":"https://msberends.github.io/AMR/reference/antibiogram.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Generate Antibiogram: Traditional, Combined, Syndromic, or Weighted-Incidence Syndromic Combination (WISCA) — antibiogram","text":"","code":"antibiogram( x, antibiotics = where(is.sir), mo_transform = \"shortname\", ab_transform = NULL, syndromic_group = NULL, add_total_n = TRUE, only_all_tested = FALSE, digits = 0, col_mo = NULL, language = get_AMR_locale(), minimum = 30, combine_SI = TRUE, sep = \" + \" ) # S3 method for antibiogram plot(x, ...) # S3 method for antibiogram autoplot(object, ...) # S3 method for antibiogram print(x, as_kable = !interactive(), ...)"},{"path":"https://msberends.github.io/AMR/reference/antibiogram.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"Generate Antibiogram: Traditional, Combined, Syndromic, or Weighted-Incidence Syndromic Combination (WISCA) — antibiogram","text":"Klinker KP et al. (2021). Antimicrobial stewardship antibiograms: importance moving beyond traditional antibiograms. Therapeutic Advances Infectious Disease, May 5;8:20499361211011373; doi:10.1177/20499361211011373 Barbieri E et al. (2021). Development Weighted-Incidence Syndromic Combination Antibiogram (WISCA) guide choice empiric antibiotic treatment urinary tract infection paediatric patients: Bayesian approach Antimicrobial Resistance & Infection Control May 1;10(1):74; doi:10.1186/s13756-021-00939-2 M39 Analysis Presentation Cumulative Antimicrobial Susceptibility Test Data, 5th Edition, 2022, Clinical Laboratory Standards Institute (CLSI). https://clsi.org/standards/products/microbiology/documents/m39/.","code":""},{"path":"https://msberends.github.io/AMR/reference/antibiogram.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Generate Antibiogram: Traditional, Combined, Syndromic, or Weighted-Incidence Syndromic Combination (WISCA) — antibiogram","text":"x data.frame containing least column microorganisms columns antibiotic results (class 'sir', see .sir()) antibiotics vector column names, (combinations ) antibiotic selectors aminoglycosides() carbapenems(). combination antibiograms, can also column names separated \"+\", \"TZP+TOB\" given data set contains columns \"TZP\" \"TOB\". See Examples. mo_transform character transform microorganism input - must \"name\", \"shortname\", \"gramstain\", one column names microorganisms data set: \"mo\", \"fullname\", \"status\", \"kingdom\", \"phylum\", \"class\", \"order\", \"family\", \"genus\", \"species\", \"subspecies\", \"rank\", \"ref\", \"source\", \"lpsn\", \"lpsn_parent\", \"lpsn_renamed_to\", \"gbif\", \"gbif_parent\", \"gbif_renamed_to\", \"prevalence\" \"snomed\". Can also NULL transform input. ab_transform character transform antibiotic input - must one column names antibiotics data set: \"ab\", \"cid\", \"name\", \"group\", \"atc\", \"atc_group1\", \"atc_group2\", \"abbreviations\", \"synonyms\", \"oral_ddd\", \"oral_units\", \"iv_ddd\", \"iv_units\" \"loinc\". Can also NULL transform input. syndromic_group column name x, values calculated split rows x, e.g. using ifelse() case_when(). See Examples. add_total_n logical indicate whether total available numbers per pathogen added table (defaults TRUE). add lowest highest number available isolate per antibiotic (e.g, E. coli 200 isolates available ciprofloxacin 150 amoxicillin, returned number \"150-200\"). only_all_tested (combination antibiograms): logical indicate isolates must tested antibiotics, see Details digits number digits use rounding col_mo column name names codes microorganisms (see .mo()), defaults first column class mo. Values coerced using .mo(). language language translate text, defaults system language (see get_AMR_locale()) minimum minimum allowed number available (tested) isolates. isolate count lower minimum return NA warning. default number 30 isolates advised Clinical Laboratory Standards Institute (CLSI) best practice, see Source. combine_SI logical indicate whether susceptibility determined results either S , instead S (defaults TRUE) sep separating character antibiotic columns combination antibiograms ... method extensions object antibiogram() object as_kable logical indicate whether printing done using knitr::kable() (default non-interactive sessions)","code":""},{"path":"https://msberends.github.io/AMR/reference/antibiogram.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Generate Antibiogram: Traditional, Combined, Syndromic, or Weighted-Incidence Syndromic Combination (WISCA) — antibiogram","text":"function returns table values 0 100 susceptibility, resistance. Remember filter data let contain first isolates! needed exclude duplicates reduce selection bias. Use first_isolate() determine data set one four available algorithms. four antibiogram types, proposed Klinker et al. (2021, doi:10.1177/20499361211011373 ), supported antibiogram(): Traditional Antibiogram Case example: Susceptibility Pseudomonas aeruginosa piperacillin/tazobactam (TZP) Code example: Combination Antibiogram Case example: Additional susceptibility Pseudomonas aeruginosa TZP + tobramycin versus TZP alone Code example: Syndromic Antibiogram Case example: Susceptibility Pseudomonas aeruginosa TZP among respiratory specimens (obtained among ICU patients ) Code example: Weighted-Incidence Syndromic Combination Antibiogram (WISCA) Case example: Susceptibility Pseudomonas aeruginosa TZP among respiratory specimens (obtained among ICU patients ) male patients age >=65 years heart failure Code example: types antibiograms can generated functions described page, can plotted (using ggplot2::autoplot() base R plot()/barplot()) printed R Markdown / Quarto formats reports using print(). Use functions specific 'table reporting' packages transform output antibiogram() needs, e.g. flextable::as_flextable() gt::gt(). Note combination antibiograms, important realise susceptibility can calculated two ways, can set only_all_tested argument (defaults FALSE). See example two antibiotics, Drug Drug B, antibiogram() works calculate %SI: Printing antibiogram non-interactive sessions done knitr::kable(), support implemented formats, \"markdown\". knitr format automatically determined printed inside knitr document (LaTeX, HTML, etc.).","code":"antibiogram(your_data, antibiotics = \"TZP\") antibiogram(your_data, antibiotics = c(\"TZP\", \"TZP+TOB\", \"TZP+GEN\")) antibiogram(your_data, antibiotics = penicillins(), syndromic_group = \"ward\") library(dplyr) your_data %>% filter(ward == \"ICU\" & specimen_type == \"Respiratory\") %>% antibiogram(antibiotics = c(\"TZP\", \"TZP+TOB\", \"TZP+GEN\"), syndromic_group = ifelse(.$age >= 65 & .$gender == \"Male\" & .$condition == \"Heart Disease\", \"Study Group\", \"Control Group\")) -------------------------------------------------------------------- only_all_tested = FALSE only_all_tested = TRUE ----------------------- ----------------------- Drug A Drug B include as include as include as include as numerator denominator numerator denominator -------- -------- ---------- ----------- ---------- ----------- S or I S or I X X X X R S or I X X X X S or I X X - - S or I R X X X X R R - X - X R - - - - S or I X X - - R - - - - - - - - --------------------------------------------------------------------"},{"path":"https://msberends.github.io/AMR/reference/antibiogram.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Generate Antibiogram: Traditional, Combined, Syndromic, or Weighted-Incidence Syndromic Combination (WISCA) — antibiogram","text":"","code":"# example_isolates is a data set available in the AMR package. # run ?example_isolates for more info. example_isolates #> # A tibble: 2,000 × 46 #> date patient age gender ward mo PEN OXA FLC AMX #> #> 1 2002-01-02 A77334 65 F Clinical B_ESCHR_COLI R NA NA NA #> 2 2002-01-03 A77334 65 F Clinical B_ESCHR_COLI R NA NA NA #> 3 2002-01-07 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 4 2002-01-07 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 5 2002-01-13 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 6 2002-01-13 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 7 2002-01-14 462729 78 M Clinical B_STPHY_AURS R NA S R #> 8 2002-01-14 462729 78 M Clinical B_STPHY_AURS R NA S R #> 9 2002-01-16 067927 45 F ICU B_STPHY_EPDR R NA R NA #> 10 2002-01-17 858515 79 F ICU B_STPHY_EPDR R NA S NA #> # … with 1,990 more rows, and 36 more variables: AMC , AMP , #> # TZP , CZO , FEP , CXM , FOX , CTX , #> # CAZ , CRO , GEN , TOB , AMK , KAN , #> # TMP , SXT , NIT , FOS , LNZ , CIP , #> # MFX , VAN , TEC , TCY , TGC , DOX , #> # ERY , CLI , AZM , IPM , MEM , MTR , #> # CHL , COL , MUP , RIF # \\donttest{ # Traditional antibiogram ---------------------------------------------- antibiogram(example_isolates, antibiotics = c(aminoglycosides(), carbapenems()) ) #> ℹ For aminoglycosides() using columns 'GEN' (gentamicin), 'TOB' #> (tobramycin), 'AMK' (amikacin) and 'KAN' (kanamycin) #> ℹ For carbapenems() using columns 'IPM' (imipenem) and 'MEM' (meropenem) #> ℹ 502 combinations had less than minimum = 30 results and were ignored #> # A tibble: 10 × 7 #> `Pathogen (N min-max)` AMK GEN IPM KAN MEM TOB #> * #> 1 CoNS (43-309) 0 86 52 0 52 22 #> 2 E. coli (0-462) 100 98 100 NA 100 97 #> 3 E. faecalis (0-39) 0 0 100 0 NA 0 #> 4 K. pneumoniae (0-58) NA 90 100 NA 100 90 #> 5 P. aeruginosa (17-30) NA 100 NA 0 NA 100 #> 6 P. mirabilis (0-34) NA 94 94 NA NA 94 #> 7 S. aureus (2-233) NA 99 NA NA NA 98 #> 8 S. epidermidis (8-163) 0 79 NA 0 NA 51 #> 9 S. hominis (3-80) NA 92 NA NA NA 85 #> 10 S. pneumoniae (11-117) 0 0 NA 0 NA 0 antibiogram(example_isolates, antibiotics = aminoglycosides(), ab_transform = \"atc\", mo_transform = \"gramstain\" ) #> ℹ For aminoglycosides() using columns 'GEN' (gentamicin), 'TOB' #> (tobramycin), 'AMK' (amikacin) and 'KAN' (kanamycin) #> ℹ 4 combinations had less than minimum = 30 results and were ignored #> # A tibble: 2 × 5 #> `Pathogen (N min-max)` J01GB01 J01GB03 J01GB04 J01GB06 #> * #> 1 Gram-negative (35-686) 96 96 0 98 #> 2 Gram-positive (436-1170) 34 63 0 0 antibiogram(example_isolates, antibiotics = carbapenems(), ab_transform = \"name\", mo_transform = \"name\" ) #> ℹ For carbapenems() using columns 'IPM' (imipenem) and 'MEM' (meropenem) #> ℹ 172 combinations had less than minimum = 30 results and were ignored #> # A tibble: 5 × 3 #> `Pathogen (N min-max)` Imipenem Meropenem #> * #> 1 Coagulase-negative Staphylococcus (CoNS) (48-48) 52 52 #> 2 Enterococcus faecalis (0-38) 100 NA #> 3 Escherichia coli (418-422) 100 100 #> 4 Klebsiella pneumoniae (51-53) 100 100 #> 5 Proteus mirabilis (27-32) 94 NA # Combined antibiogram ------------------------------------------------- # combined antibiotics yield higher empiric coverage antibiogram(example_isolates, antibiotics = c(\"TZP\", \"TZP+TOB\", \"TZP+GEN\"), mo_transform = \"gramstain\" ) #> ℹ 3 combinations had less than minimum = 30 results and were ignored #> # A tibble: 2 × 4 #> `Pathogen (N min-max)` TZP `TZP + GEN` `TZP + TOB` #> * #> 1 Gram-negative (641-693) 88 99 98 #> 2 Gram-positive (345-1044) 86 98 95 antibiogram(example_isolates, antibiotics = c(\"TZP\", \"TZP+TOB\"), mo_transform = \"gramstain\", ab_transform = \"name\", sep = \" & \" ) #> ℹ 2 combinations had less than minimum = 30 results and were ignored #> # A tibble: 2 × 3 #> `Pathogen (N min-max)` `Piperacillin/tazobactam` Piperacillin/tazobactam & …¹ #> * #> 1 Gram-negative (641-693) 88 98 #> 2 Gram-positive (345-550) 86 95 #> # … with abbreviated variable name ¹`Piperacillin/tazobactam & Tobramycin` # Syndromic antibiogram ------------------------------------------------ # the data set could contain a filter for e.g. respiratory specimens antibiogram(example_isolates, antibiotics = c(aminoglycosides(), carbapenems()), syndromic_group = \"ward\" ) #> ℹ For aminoglycosides() using columns 'GEN' (gentamicin), 'TOB' #> (tobramycin), 'AMK' (amikacin) and 'KAN' (kanamycin) #> ℹ For carbapenems() using columns 'IPM' (imipenem) and 'MEM' (meropenem) #> ℹ 1581 combinations had less than minimum = 30 results and were ignored #> # A tibble: 14 × 8 #> `Syndromic Group` `Pathogen (N min-max)` AMK GEN IPM KAN MEM TOB #> * #> 1 Clinical CoNS (23-205) NA 89 57 NA 57 26 #> 2 ICU CoNS (10-73) NA 79 NA NA NA NA #> 3 Outpatient CoNS (3-31) NA 84 NA NA NA NA #> 4 Clinical E. coli (0-299) 100 98 100 NA 100 98 #> 5 ICU E. coli (0-137) 100 99 100 NA 100 96 #> 6 Clinical K. pneumoniae (0-51) NA 92 100 NA 100 92 #> 7 Clinical P. mirabilis (0-30) NA 100 NA NA NA 100 #> 8 Clinical S. aureus (2-150) NA 99 NA NA NA 97 #> 9 ICU S. aureus (0-66) NA 100 NA NA NA NA #> 10 Clinical S. epidermidis (4-79) NA 82 NA NA NA 55 #> 11 ICU S. epidermidis (4-75) NA 72 NA NA NA 41 #> 12 Clinical S. hominis (1-45) NA 96 NA NA NA 94 #> 13 Clinical S. pneumoniae (5-78) 0 0 NA 0 NA 0 #> 14 ICU S. pneumoniae (5-30) 0 0 NA 0 NA 0 # now define a data set with only E. coli ex1 <- example_isolates[which(mo_genus() == \"Escherichia\"), ] #> ℹ Using column 'mo' as input for mo_genus() # with a custom language, though this will be determined automatically # (i.e., this table will be in Spanish on Spanish systems) antibiogram(ex1, antibiotics = aminoglycosides(), ab_transform = \"name\", syndromic_group = ifelse(ex1$ward == \"ICU\", \"UCI\", \"No UCI\" ), language = \"es\" ) #> ℹ For aminoglycosides() using columns 'GEN' (gentamicin), 'TOB' #> (tobramycin), 'AMK' (amikacin) and 'KAN' (kanamycin) #> ℹ 2 combinations had less than minimum = 30 results and were ignored #> # A tibble: 2 × 5 #> `Grupo sindrómico` `Patógeno (N min-max)` Amikacina Gentamicina Tobramicina #> * #> 1 No UCI E. coli (0-325) 100 98 98 #> 2 UCI E. coli (0-137) 100 99 96 # Weighted-incidence syndromic combination antibiogram (WISCA) --------- # the data set could contain a filter for e.g. respiratory specimens/ICU antibiogram(example_isolates, antibiotics = c(\"AMC\", \"AMC+CIP\", \"TZP\", \"TZP+TOB\"), mo_transform = \"gramstain\", minimum = 10, # this should be >=30, but now just as example syndromic_group = ifelse(example_isolates$age >= 65 & example_isolates$gender == \"M\", \"WISCA Group 1\", \"WISCA Group 2\" ) ) #> ℹ 8 combinations had less than minimum = 10 results and were ignored #> # A tibble: 4 × 6 #> `Syndromic Group` `Pathogen (N min-max)` AMC `AMC + CIP` TZP `TZP + TOB` #> *