(v2.1.1.9141) new AMR selectors, eucast overwrite arg

.github/workflows/check-current-testthat.yaml

@@ -86,7 +86,7 @@ jobs:
 
       - uses: r-lib/actions/setup-r-dependencies@v2
         with:
-          extra-packages: any::rcmdcheck
+          extra-packages: any::rcmdcheck, any::pkgload
           needs: check
           upgrade: 'TRUE'
 

.github/workflows/check-old-tinytest.yaml

@@ -92,7 +92,7 @@ jobs:
           mv DESCRIPTION2 DESCRIPTION
         shell: bash
 
-      - name: Run R CMD check
+      - name: Run R CMD check with tinytest
         if: always()
         env:
           # see https://rstudio.github.io/r-manuals/r-ints/Tools.html for an overview

DESCRIPTION

@@ -1,6 +1,6 @@
 Package: AMR
-Version: 2.1.1.9140
+Version: 2.1.1.9141
-Date: 2025-02-05
+Date: 2025-02-07
 Title: Antimicrobial Resistance Data Analysis
 Description: Functions to simplify and standardise antimicrobial resistance (AMR)
   data analysis and to work with microbial and antimicrobial properties by

NAMESPACE

@@ -236,6 +236,7 @@ export(is.mo)
 export(is.sir)
 export(is_new_episode)
 export(is_sir_eligible)
+export(isoxazolylpenicillins)
 export(italicise_taxonomy)
 export(italicize_taxonomy)
 export(key_antimicrobials)
@@ -293,6 +294,7 @@ export(mo_type)
 export(mo_uncertainties)
 export(mo_url)
 export(mo_year)
+export(monobactams)
 export(mrgn)
 export(n_sir)
 export(nitrofurans)

NEWS.md

@@ -1,4 +1,4 @@
-# AMR 2.1.1.9140
+# AMR 2.1.1.9141
 
 *(this beta version will eventually become v3.0. We're happy to reach a new major milestone soon, which will be all about the new One Health support! Install this beta using [the instructions here](https://msberends.github.io/AMR/#latest-development-version).)*
 
@@ -45,25 +45,28 @@ This package now supports not only tools for AMR data analysis in clinical setti
   * Users can now set their own criteria (using regular expressions) as to what should be considered S, I, R, SDD, and NI.
   * To get quantitative values, `as.double()` on a `sir` object will return 1 for S, 2 for SDD/I, and 3 for R (NI will become `NA`). Other functions using `sir` classes (e.g., `summary()`) are updated to reflect the change to contain NI and SDD.
 * `antibiogram()` function
-  * New argument `formatting_type` to set any of the 12 options for the formatting of all 'cells'. This defaults to `10`, changing the output of antibiograms to cells with `5% (15/300)` instead of the previous standard of just `5`.
+  * New argument `formatting_type` to set any of the 22 options for the formatting of all 'cells'. This defaults to `10` for non-WISCA and `14` for WISCA, changing the output of antibiograms to cells with more info.
   * For this reason, `add_total_n` is now `FALSE` at default since the denominators are added to the cells
   * The `ab_transform` argument now defaults to `"name"`, displaying antibiotic column names instead of codes
 * Antimicrobial selectors (previously: *antibiotic selectors*)
   * 'Antibiotic selectors' are now called 'antimicrobial selectors' since their scope is broader than just antibiotics. All documentation have been updated, and `ab_class()` and `ab_selector()` have been replaced with `amr_class()` and `amr_selector()`. The old functions are now deprecated and will be removed in a future version.
-  * Added selectors `nitrofurans()`, `phenicols()`, and `rifamycins()`
+  * Added selectors `isoxazolylpenicillins()`, `monobactams()`, `nitrofurans()`, `phenicols()`, and `rifamycins()`
-  * When using antimicrobial selectors (such as `aminoglycosides()`) that exclude non-treatable drugs (such as gentamicin-high), the function now always returns a warning that these can be included using `only_treatable = FALSE`
+  * When using antimicrobial selectors that exclude non-treatable drugs (such as gentamicin-high when using `aminoglycosides()`), the function now always returns a warning that these can be included using `only_treatable = FALSE`
   * Added a new argument `return_all` to all selectors, which defaults to `TRUE` to include any match. With `FALSE`, the old behaviour, only the first hit for each unique antimicrobial is returned.
   * All selectors can now be run as a separate command to retrieve a vector of all possible antimicrobials that the selector can select
+  * The selectors `lincosamides()` and `macrolides()` do not overlap anymore - each antibiotic is now classified as either of these and not both
 * `antibiotics` data set
   * Added "clindamycin inducible screening" as `CLI1`. Since clindamycin is a lincosamide, the antimicrobial selector `lincosamides()` now contains the argument `only_treatable = TRUE` (similar to other antibiotic selectors that contain non-treatable drugs)
   * Added Amorolfine (`AMO`, D01AE16), which is now also part of the `antifungals()` selector
   * Added Efflux (`EFF`), to allow mapping to AMRFinderPlus
+  * Added Tigemonam (`TNM`), a monobactam
 * MICs
   * Added as valid levels: 4096, 6 powers of 0.0625, and 5 powers of 192 (192, 384, 576, 768, 960)
   * Added new argument `keep_operators` to `as.mic()`. This can be `"all"` (default), `"none"`, or `"edges"`. This argument is also available in the new `rescale_mic()` and `scale_*_mic()` functions.
   * Comparisons of MIC values are now more strict. For example, `>32` is higher than (and never equal to) `32`. Thus, `as.mic(">32") == as.mic(32)` now returns `FALSE`, and `as.mic(">32") > as.mic(32)` now returns `TRUE`.
   * Sorting of MIC values (using `sort()`) was fixed in the same manner; `<0.001` now gets sorted before `0.001`, and `>0.001` gets sorted after `0.001`.
   * Intermediate log2 levels used for MIC plotting are now more common values instead of following a strict dilution range
+* `eucast_rules()` now has an argument `overwrite` (default: `TRUE`) to indicate whether non-`NA` values should be overwritten
 * Disks of 0 to 5 mm are now allowed, the newly allowed range for disk diffusion (`as.disk()`) is now between 0 and 50 mm
 * Updated `italicise_taxonomy()` to support HTML output
 * `custom_eucast_rules()` now supports multiple antibiotics and antibiotic groups to be affected by a single rule

PythonPackage/AMR/AMR.egg-info/PKG-INFO

@@ -1,6 +1,6 @@
 Metadata-Version: 2.2
 Name: AMR
-Version: 2.1.1.9140
+Version: 2.1.1.9141
 Summary: A Python wrapper for the AMR R package
 Home-page: https://github.com/msberends/AMR
 Author: Matthijs Berends

PythonPackage/AMR/AMR/__init__.py

@@ -45,9 +45,11 @@ from .functions import cephalosporins_4th
 from .functions import cephalosporins_5th
 from .functions import fluoroquinolones
 from .functions import glycopeptides
+from .functions import isoxazolylpenicillins
 from .functions import lincosamides
 from .functions import lipoglycopeptides
 from .functions import macrolides
+from .functions import monobactams
 from .functions import nitrofurans
 from .functions import oxazolidinones
 from .functions import penicillins

PythonPackage/AMR/AMR/functions.py

@@ -165,6 +165,9 @@ def fluoroquinolones(only_sir_columns = False, *args, **kwargs):
 def glycopeptides(only_sir_columns = False, *args, **kwargs):
     """See our website of the R package for the manual: https://msberends.github.io/AMR/index.html"""
     return convert_to_python(amr_r.glycopeptides(only_sir_columns = False, *args, **kwargs))
+def isoxazolylpenicillins(only_sir_columns = False, *args, **kwargs):
+    """See our website of the R package for the manual: https://msberends.github.io/AMR/index.html"""
+    return convert_to_python(amr_r.isoxazolylpenicillins(only_sir_columns = False, *args, **kwargs))
 def lincosamides(only_sir_columns = False, *args, **kwargs):
     """See our website of the R package for the manual: https://msberends.github.io/AMR/index.html"""
     return convert_to_python(amr_r.lincosamides(only_sir_columns = False, *args, **kwargs))
@@ -174,6 +177,9 @@ def lipoglycopeptides(only_sir_columns = False, *args, **kwargs):
 def macrolides(only_sir_columns = False, *args, **kwargs):
     """See our website of the R package for the manual: https://msberends.github.io/AMR/index.html"""
     return convert_to_python(amr_r.macrolides(only_sir_columns = False, *args, **kwargs))
+def monobactams(only_sir_columns = False, *args, **kwargs):
+    """See our website of the R package for the manual: https://msberends.github.io/AMR/index.html"""
+    return convert_to_python(amr_r.monobactams(only_sir_columns = False, *args, **kwargs))
 def nitrofurans(only_sir_columns = False, *args, **kwargs):
     """See our website of the R package for the manual: https://msberends.github.io/AMR/index.html"""
     return convert_to_python(amr_r.nitrofurans(only_sir_columns = False, *args, **kwargs))

PythonPackage/AMR/setup.py

@@ -2,7 +2,7 @@ from setuptools import setup, find_packages
 
 setup(
     name='AMR',
-    version='2.1.1.9140',
+    version='2.1.1.9141',
     packages=find_packages(),
     install_requires=[
         'rpy2',

R/aa_globals.R

@@ -113,7 +113,7 @@ TAXONOMY_VERSION <- list(
     name = "Systematized Nomenclature of Medicine - Clinical Terms (SNOMED-CT)",
     accessed_date = as.Date("2024-07-16"),
     citation = "Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microorganism', OID 2.16.840.1.114222.4.11.1009 (v12).",
-    url = "https://www.cdc.gov/phin/php/phinvads"
+    url = "https://www.cdc.gov/phin/php/phinvads/"
   ),
   LOINC = list(
     name = "Logical Observation Identifiers Names and Codes (LOINC)",

R/amr_selectors.R

@@ -403,6 +403,14 @@ glycopeptides <- function(only_sir_columns = FALSE, return_all = TRUE, ...) {
   amr_select_exec("glycopeptides", only_sir_columns = only_sir_columns, return_all = return_all)
 }
 
+#' @rdname antimicrobial_class_selectors
+#' @export
+isoxazolylpenicillins <- function(only_sir_columns = FALSE, return_all = TRUE, ...) {
+  meet_criteria(only_sir_columns, allow_class = "logical", has_length = 1)
+  meet_criteria(return_all, allow_class = "logical", has_length = 1)
+  amr_select_exec("isoxazolylpenicillins", only_sir_columns = only_sir_columns, return_all = return_all)
+}
+
 #' @rdname antimicrobial_class_selectors
 #' @export
 lincosamides <- function(only_sir_columns = FALSE, only_treatable = TRUE, return_all = TRUE, ...) {
@@ -428,6 +436,14 @@ macrolides <- function(only_sir_columns = FALSE, return_all = TRUE, ...) {
   amr_select_exec("macrolides", only_sir_columns = only_sir_columns, return_all = return_all)
 }
 
+#' @rdname antimicrobial_class_selectors
+#' @export
+monobactams <- function(only_sir_columns = FALSE, return_all = TRUE, ...) {
+  meet_criteria(only_sir_columns, allow_class = "logical", has_length = 1)
+  meet_criteria(return_all, allow_class = "logical", has_length = 1)
+  amr_select_exec("monobactams", only_sir_columns = only_sir_columns, return_all = return_all)
+}
+
 #' @rdname antimicrobial_class_selectors
 #' @export
 nitrofurans <- function(only_sir_columns = FALSE, return_all = TRUE, ...) {

R/antibiogram.R

@@ -481,10 +481,10 @@ antibiogram.default <- function(x,
   x$`.mo` <- x[, col_mo, drop = TRUE]
   if (is.null(mo_transform)) {
     # leave as is, no transformation
-  } else if (is.na(mo_transform)) {
-    x$`.mo` <- NA_character_
   } else if (is.function(mo_transform)) {
     x$`.mo` <- mo_transform(x$`.mo`)
+  } else if (is.na(mo_transform)) {
+    x$`.mo` <- NA_character_
   } else if (mo_transform == "gramstain") {
     x$`.mo` <- mo_gramstain(x$`.mo`, language = language)
   } else if (mo_transform == "shortname") {
@@ -602,8 +602,8 @@ antibiogram.default <- function(x,
     on.exit(close(progress))
     
     out$coverage <- NA_real_
-    out$lower <- NA_real_
+    out$lower_ci <- NA_real_
-    out$upper <- NA_real_
+    out$upper_ci <- NA_real_
     out$gamma_posterior <- NA_real_
     out$beta_posterior_1 <- NA_real_
     out$beta_posterior_2 <- NA_real_
@@ -657,8 +657,8 @@ antibiogram.default <- function(x,
       coverage_ci <- unname(stats::quantile(coverage_simulations, probs = probs))
       
       out$coverage[i] <- coverage_mean
-      out$lower[i] <- coverage_ci[1]
+      out$lower_ci[i] <- coverage_ci[1]
-      out$upper[i] <- coverage_ci[2]
+      out$upper_ci[i] <- coverage_ci[2]
     }
     # remove progress bar from console
     close(progress)
@@ -705,8 +705,8 @@ antibiogram.default <- function(x,
   if (wisca == TRUE) {
     long_numeric <- out %pm>%
       pm_summarise(coverage = coverage,
-                   lower_ci = lower,
+                   lower_ci = lower_ci,
-                   upper_ci = upper,
+                   upper_ci = upper_ci,
                    n_tested = total,
                    n_total = total_rows,
                    n_susceptible = numerator,
@@ -758,12 +758,12 @@ antibiogram.default <- function(x,
   if (formatting_type == 10) out <- out %pm>% pm_summarise(out_value = paste0(round((numerator / total) * 100, digits = digits), "% (", numerator, "/", total, ")"))
   if (formatting_type == 11) out <- out %pm>% pm_summarise(out_value = paste0(round((numerator / total) * 100, digits = digits), " (N=", numerator, "/", total, ")"))
   if (formatting_type == 12) out <- out %pm>% pm_summarise(out_value = paste0(round((numerator / total) * 100, digits = digits), "% (N=", numerator, "/", total, ")"))
-  if (formatting_type == 13) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), " (", round(lower * 100, digits = digits), "-", round(upper * 100, digits = digits), ")"))
+  if (formatting_type == 13) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), " (", round(lower_ci * 100, digits = digits), "-", round(upper_ci * 100, digits = digits), ")"))
-  if (formatting_type == 14) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), "% (", round(lower * 100, digits = digits), "-", round(upper * 100, digits = digits), "%)"))
+  if (formatting_type == 14) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), "% (", round(lower_ci * 100, digits = digits), "-", round(upper_ci * 100, digits = digits), "%)"))
-  if (formatting_type == 15) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), " (", round(lower * 100, digits = digits), "-", round(upper * 100, digits = digits), ",", total, ")"))
+  if (formatting_type == 15) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), " (", round(lower_ci * 100, digits = digits), "-", round(upper_ci * 100, digits = digits), ",", total, ")"))
-  if (formatting_type == 16) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), "% (", round(lower * 100, digits = digits), "-", round(upper * 100, digits = digits), "%,", total, ")"))
+  if (formatting_type == 16) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), "% (", round(lower_ci * 100, digits = digits), "-", round(upper_ci * 100, digits = digits), "%,", total, ")"))
-  if (formatting_type == 17) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), " (", round(lower * 100, digits = digits), "-", round(upper * 100, digits = digits), ",N=", total, ")"))
+  if (formatting_type == 17) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), " (", round(lower_ci * 100, digits = digits), "-", round(upper_ci * 100, digits = digits), ",N=", total, ")"))
-  if (formatting_type == 18) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), "% (", round(lower * 100, digits = digits), "-", round(upper * 100, digits = digits), "%,N=", total, ")"))
+  if (formatting_type == 18) out <- out %pm>% pm_summarise(out_value = paste0(round(coverage * 100, digits = digits), "% (", round(lower_ci * 100, digits = digits), "-", round(upper_ci * 100, digits = digits), "%,N=", total, ")"))
   
   # transform names of antibiotics
   ab_naming_function <- function(x, t, l, s) {
@@ -1100,11 +1100,11 @@ plot.antibiogram <- function(x, ...) {
     )
     
     if (isTRUE(attributes(x)$wisca)) {
-      lower <- df_sub$lower * 100
+      lower_ci <- df_sub$lower_ci * 100
-      upper <- df_sub$upper * 100
+      upper_ci <- df_sub$upper_ci * 100
       arrows(
-        x0 = bp, y0 = lower,  # Start of error bar (lower bound)
+        x0 = bp, y0 = lower_ci,  # Start of error bar (lower bound)
-        x1 = bp, y1 = upper,  # End of error bar (upper bound)
+        x1 = bp, y1 = upper_ci,  # End of error bar (upper bound)
         angle = 90, code = 3, length = 0.05, col = "black"
       )
     }
@@ -1151,7 +1151,7 @@ autoplot.antibiogram <- function(object, ...) {
     )
   if (isTRUE(attributes(object)$wisca)) {
     out <- out + 
-      ggplot2::geom_errorbar(mapping = ggplot2::aes(ymin = lower * 100, ymax = upper * 100),
+      ggplot2::geom_errorbar(mapping = ggplot2::aes(ymin = lower_ci * 100, ymax = upper_ci * 100),
                              position = ggplot2::position_dodge2(preserve = "single"),
                              width = 0.5)
   }

R/eucast_rules.R

@@ -56,7 +56,7 @@ format_eucast_version_nr <- function(version, markdown = TRUE) {
 #' Apply EUCAST Rules
 #'
 #' @description
-#' Apply rules for clinical breakpoints and intrinsic resistance as defined by the European Committee on Antimicrobial Susceptibility Testing (EUCAST, <https://www.eucast.org>), see *Source*. Use [eucast_dosage()] to get a [data.frame] with advised dosages of a certain bug-drug combination, which is based on the [dosage] data set.
+#' Apply rules from clinical breakpoints notes and expected resistant phenotypes as defined by the European Committee on Antimicrobial Susceptibility Testing (EUCAST, <https://www.eucast.org>), see *Source*. Use [eucast_dosage()] to get a [data.frame] with advised dosages of a certain bug-drug combination, which is based on the [dosage] data set.
 #'
 #' To improve the interpretation of the antibiogram before EUCAST rules are applied, some non-EUCAST rules can applied at default, see *Details*.
 #' @param x a data set with antibiotic columns, such as `amox`, `AMX` and `AMC`
@@ -72,6 +72,7 @@ format_eucast_version_nr <- function(version, markdown = TRUE) {
 #' @param administration route of administration, either `r vector_or(dosage$administration)`
 #' @param only_sir_columns a [logical] to indicate whether only antibiotic columns must be detected that were transformed to class `sir` (see [as.sir()]) on beforehand (default is `FALSE`)
 #' @param custom_rules custom rules to apply, created with [custom_eucast_rules()]
+#' @param overwrite a [logical] to indicate whether non-`NA` values must be overwritten (defaults to `TRUE`). With `FALSE`, only `NA` values are changed.
 #' @inheritParams first_isolate
 #' @details
 #' **Note:** This function does not translate MIC values to SIR values. Use [as.sir()] for that. \cr
@@ -172,6 +173,7 @@ eucast_rules <- function(x,
                          ampc_cephalosporin_resistance = NA,
                          only_sir_columns = FALSE,
                          custom_rules = NULL,
+                         overwrite = TRUE,
                          ...) {
   meet_criteria(x, allow_class = "data.frame")
   meet_criteria(col_mo, allow_class = "character", has_length = 1, is_in = colnames(x), allow_NULL = TRUE)
@@ -184,6 +186,7 @@ eucast_rules <- function(x,
   meet_criteria(ampc_cephalosporin_resistance, allow_class = c("logical", "character", "sir"), has_length = 1, allow_NA = TRUE, allow_NULL = TRUE)
   meet_criteria(only_sir_columns, allow_class = "logical", has_length = 1)
   meet_criteria(custom_rules, allow_class = "custom_eucast_rules", allow_NULL = TRUE)
+  meet_criteria(overwrite, allow_class = "logical", has_length = 1)
 
   add_MO_lookup_to_AMR_env()
 
@@ -254,18 +257,18 @@ eucast_rules <- function(x,
       } else {
         # opening
         if (n_added > 0 && n_changed == 0) {
-          cat(font_green(" ("))
+          cat(font_bold(font_green(" (")))
         } else if (n_added == 0 && n_changed > 0) {
-          cat(font_blue(" ("))
+          cat(font_bold(font_blue(" (")))
         } else {
           cat(font_grey(" ("))
         }
         # additions
         if (n_added > 0) {
           if (n_added == 1) {
-            cat(font_green("1 value added"))
+            cat(font_bold(font_green("1 value added")))
           } else {
-            cat(font_green(formatnr(n_added), "values added"))
+            cat(font_bold(font_green(formatnr(n_added), "values added")))
           }
         }
         # separator
@@ -275,16 +278,16 @@ eucast_rules <- function(x,
         # changes
         if (n_changed > 0) {
           if (n_changed == 1) {
-            cat(font_blue("1 value changed"))
+            cat(font_bold(font_blue("1 value changed")))
           } else {
-            cat(font_blue(formatnr(n_changed), "values changed"))
+            cat(font_bold(font_blue(formatnr(n_changed), "values changed")))
           }
         }
         # closing
         if (n_added > 0 && n_changed == 0) {
-          cat(font_green(")\n"))
+          cat(font_bold(font_green(")\n")))
         } else if (n_added == 0 && n_changed > 0) {
-          cat(font_blue(")\n"))
+          cat(font_bold(font_blue(")\n")))
         } else {
           cat(font_grey(")\n"))
         }
@@ -327,6 +330,10 @@ eucast_rules <- function(x,
     }
     cols_ab <- c(cols_ab, c(AMP = unname(cols_ab[names(cols_ab) == "AMX"])))
   }
+  if (!"FOX" %in% names(cols_ab) && "FOX1" %in% names(cols_ab)) {
+    # cefoxitin column is missing, but cefoxitin screening is available
+    cols_ab <- c(cols_ab, c(FOX = unname(cols_ab[names(cols_ab) == "FOX1"])))
+  }
 
   # data preparation ----
   if (isTRUE(info) && NROW(x) > 10000) {
@@ -359,10 +366,8 @@ eucast_rules <- function(x,
         # like PEN,FOX S
         x <- paste(paste0(ab_names, collapse = " and "), "are both")
       } else {
-        # like PEN,FOX,GEN S (although dependency on > 2 ABx does not exist at the moment)
+        # like PEN,FOX,GEN S
-        # nolint start
+        x <- paste(paste0(ab_names, collapse = " and "), "are all")
-        # x <- paste(paste0(ab_names, collapse = " and "), "are all")
-        # nolint end
       }
       return(paste0(x, " '", ab_results, "'"))
     } else {
@@ -373,7 +378,7 @@ eucast_rules <- function(x,
           ab_names[2], " is '", ab_results[2], "'"
         )
       } else {
-        # like PEN,FOX,GEN S,R,R (although dependency on > 2 ABx does not exist at the moment)
+        # like PEN,FOX,GEN S,R,R
         paste0(
           ab_names[1], " is '", ab_results[1], "' and ",
           ab_names[2], " is '", ab_results[2], "' and ",
@@ -452,7 +457,7 @@ eucast_rules <- function(x,
   n_added <- 0
   n_changed <- 0
 
-  # Other rules: enzyme inhibitors ------------------------------------------
+  # >>> Apply Other rules: enzyme inhibitors <<< ------------------------------------------
   if (any(c("all", "other") %in% rules)) {
     if (isTRUE(info)) {
       cat("\n")
@@ -488,7 +493,7 @@ eucast_rules <- function(x,
         col_base <- unname(cols_ab[ab_enzyme$base_ab[i]])
         col_enzyme <- unname(cols_ab[ab_enzyme$enzyme_ab[i]])
 
-        # Set base to R where base + enzyme inhibitor is R ----
+        ## Set base to R where base + enzyme inhibitor is R ----
         rule_current <- paste0(
           ab_enzyme$base_name[i], " ('", font_bold(col_base), "') = R if ",
           tolower(ab_enzyme$enzyme_name[i]), " ('", font_bold(col_enzyme), "') = R"
@@ -512,7 +517,8 @@ eucast_rules <- function(x,
           original_data = x.bak,
           warned = warned,
           info = info,
-          verbose = verbose
+          verbose = verbose,
+          overwrite = overwrite
         )
         n_added <- n_added + run_changes$added
         n_changed <- n_changed + run_changes$changed
@@ -528,7 +534,7 @@ eucast_rules <- function(x,
           n_changed <- 0
         }
 
-        # Set base + enzyme inhibitor to S where base is S ----
+        ## Set base + enzyme inhibitor to S where base is S ----
         rule_current <- paste0(
           ab_enzyme$enzyme_name[i], " ('", font_bold(col_enzyme), "') = S if ",
           tolower(ab_enzyme$base_name[i]), " ('", font_bold(col_base), "') = S"
@@ -584,7 +590,7 @@ eucast_rules <- function(x,
     custom_rules <- NULL
   }
 
-  # Official EUCAST rules ---------------------------------------------------
+  # >>> Apply Official EUCAST rules <<< ---------------------------------------------------
   eucast_notification_shown <- FALSE
   if (!is.null(list(...)$eucast_rules_df)) {
     # this allows: eucast_rules(x, eucast_rules_df = AMR:::EUCAST_RULES_DF %>% filter(is.na(have_these_values)))
@@ -594,7 +600,7 @@ eucast_rules <- function(x,
     eucast_rules_df <- EUCAST_RULES_DF
   }
 
-  # filter on user-set guideline versions ----
+  ## filter on user-set guideline versions ----
   if (any(c("all", "breakpoints") %in% rules)) {
     eucast_rules_df <- subset(
       eucast_rules_df,
@@ -609,7 +615,7 @@ eucast_rules <- function(x,
         (reference.rule_group %like% "expert" & reference.version == version_expertrules)
     )
   }
-  # filter out AmpC de-repressed cephalosporin-resistant mutants ----
+  ## filter out AmpC de-repressed cephalosporin-resistant mutants ----
   # no need to filter on version number here - the rules contain these version number, so are inherently filtered
   # cefotaxime, ceftriaxone, ceftazidime
   if (is.null(ampc_cephalosporin_resistance) || isFALSE(ampc_cephalosporin_resistance)) {
@@ -624,7 +630,7 @@ eucast_rules <- function(x,
     eucast_rules_df[which(eucast_rules_df$reference.rule %like% "ampc"), "to_value"] <- as.character(ampc_cephalosporin_resistance)
   }
 
-  # Go over all rules and apply them ----
+  ## Go over all rules and apply them ----
   for (i in seq_len(nrow(eucast_rules_df))) {
     rule_previous <- eucast_rules_df[max(1, i - 1), "reference.rule", drop = TRUE]
     rule_current <- eucast_rules_df[i, "reference.rule", drop = TRUE]
@@ -664,19 +670,19 @@ eucast_rules <- function(x,
     }
 
     if (isTRUE(info)) {
-      # Print EUCAST intro ------------------------------------------------------
+      ## Print EUCAST intro ------------------------------------------------------
       if (rule_group_current %unlike% "other" && eucast_notification_shown == FALSE) {
         cat(
           paste0(
             "\n", font_grey(strrep("-", 0.95 * getOption("width", 100))), "\n",
             word_wrap("Rules by the ", font_bold("European Committee on Antimicrobial Susceptibility Testing (EUCAST)")), "\n",
-            font_blue("https://eucast.org/"), "\n"
+            font_blue(font_url("https://eucast.org/")), "\n"
           )
         )
         eucast_notification_shown <- TRUE
       }
 
-      # Print rule (group) ------------------------------------------------------
+      ## Print rule (group) ------------------------------------------------------
       if (rule_group_current != rule_group_previous) {
         # is new rule group, one of Breakpoints, Expert Rules and Other
         cat(font_bold(
@@ -703,7 +709,7 @@ eucast_rules <- function(x,
           )
         ), "\n")
       }
-      # Print rule  -------------------------------------------------------------
+      ## Print rule  -------------------------------------------------------------
       if (rule_current != rule_previous) {
         # is new rule within group, print its name
         cat(italicise_taxonomy(
@@ -717,7 +723,7 @@ eucast_rules <- function(x,
       }
     }
 
-    # Get rule from file ------------------------------------------------------
+    ## Get rule from file ------------------------------------------------------
     if_mo_property <- trimws(eucast_rules_df[i, "if_mo_property", drop = TRUE])
     like_is_one_of <- trimws(eucast_rules_df[i, "like.is.one_of", drop = TRUE])
     mo_value <- trimws(eucast_rules_df[i, "this_value", drop = TRUE])
@@ -824,7 +830,7 @@ eucast_rules <- function(x,
 
     cols <- get_ab_from_namespace(target_antibiotics, cols_ab)
 
-    # Apply rule on data ------------------------------------------------------
+    ## Apply rule on data ------------------------------------------------------
     # this will return the unique number of changes
     run_changes <- edit_sir(
       x = x,
@@ -842,14 +848,15 @@ eucast_rules <- function(x,
       original_data = x.bak,
       warned = warned,
       info = info,
-      verbose = verbose
+      verbose = verbose,
+      overwrite = overwrite
     )
     n_added <- n_added + run_changes$added
     n_changed <- n_changed + run_changes$changed
     verbose_info <- run_changes$verbose_info
     x <- run_changes$output
     warn_lacking_sir_class <- c(warn_lacking_sir_class, run_changes$sir_warn)
-    # Print number of new changes ---------------------------------------------
+    ## Print number of new changes ---------------------------------------------
     if (isTRUE(info) && rule_next != rule_current) {
       # print only on last one of rules in this group
       txt_ok(n_added = n_added, n_changed = n_changed, warned = warned)
@@ -859,7 +866,7 @@ eucast_rules <- function(x,
     }
   } # end of going over all rules
 
-  # Apply custom rules ----
+  # >>> Apply custom rules <<< ----
   if (!is.null(custom_rules)) {
     if (isTRUE(info)) {
       cat("\n")
@@ -910,14 +917,15 @@ eucast_rules <- function(x,
         original_data = x.bak,
         warned = warned,
         info = info,
-        verbose = verbose
+        verbose = verbose,
+        overwrite = overwrite
       )
       n_added <- n_added + run_changes$added
       n_changed <- n_changed + run_changes$changed
       verbose_info <- run_changes$verbose_info
       x <- run_changes$output
       warn_lacking_sir_class <- c(warn_lacking_sir_class, run_changes$sir_warn)
-      # Print number of new changes ---------------------------------------------
+      ## Print number of new changes ---------------------------------------------
       if (isTRUE(info) && rule_next != rule_current) {
         # print only on last one of rules in this group
         txt_ok(n_added = n_added, n_changed = n_changed, warned = warned)
@@ -940,6 +948,10 @@ eucast_rules <- function(x,
       pm_select(row, pm_everything()) %pm>%
       pm_filter(!is.na(new) | is.na(new) & !is.na(old)) %pm>%
       pm_arrange(row, rule_group, rule_name, col)
+    if (isFALSE(overwrite)) {
+      verbose_info <- verbose_info %pm>%
+        pm_filter(!old %in% levels(NA_sir_))
+    }
     rownames(verbose_info) <- NULL
   }
 
@@ -1074,7 +1086,8 @@ edit_sir <- function(x,
                      original_data,
                      warned,
                      info,
-                     verbose) {
+                     verbose,
+                     overwrite) {
   cols <- unique(cols[!is.na(cols) & !is.null(cols)])
 
   # for Verbose Mode, keep track of all changes and return them
@@ -1101,9 +1114,14 @@ edit_sir <- function(x,
     if (any(!vapply(FUN.VALUE = logical(1), x[, cols, drop = FALSE], is.sir), na.rm = TRUE)) {
       track_changes$sir_warn <- cols[!vapply(FUN.VALUE = logical(1), x[, cols, drop = FALSE], is.sir)]
     }
+    non_SIR <- !(new_edits[rows, cols] == "S" | new_edits[rows, cols] == "I" | new_edits[rows, cols] == "R" | new_edits[rows, cols] == "SDD" | new_edits[rows, cols] == "NI")
     tryCatch(
       # insert into original table
-      new_edits[rows, cols] <- to,
+      if (isTRUE(overwrite)) {
+        new_edits[rows, cols] <- to
+      } else {
+        new_edits[rows, cols][non_SIR] <- to
+      },
       warning = function(w) {
         if (w$message %like% "invalid factor level") {
           xyz <- vapply(FUN.VALUE = logical(1), cols, function(col) {
@@ -1113,7 +1131,11 @@ edit_sir <- function(x,
             )
             TRUE
           })
-          suppressWarnings(new_edits[rows, cols] <<- to)
+          if (isTRUE(overwrite)) {
+            suppressWarnings(new_edits[rows, cols] <<- to)
+          } else {
+            suppressWarnings(new_edits[rows, cols][non_SIR] <<- to)
+          }
           warning_(
             "in `eucast_rules()`: value \"", to, "\" added to the factor levels of column",
             ifelse(length(cols) == 1, "", "s"),

R/first_isolate.R

@@ -51,8 +51,8 @@
 #' @param include_untested_sir a [logical] to indicate whether also rows without antibiotic results are still eligible for becoming a first isolate. Use `include_untested_sir = FALSE` to always return `FALSE` for such rows. This checks the data set for columns of class `sir` and consequently requires transforming columns with antibiotic results using [as.sir()] first.
 #' @param ... arguments passed on to [first_isolate()] when using [filter_first_isolate()], otherwise arguments passed on to [key_antimicrobials()] (such as `universal`, `gram_negative`, `gram_positive`)
 #' @details
-#' The methodology implemented in these functions is based on the research overview by Hindler *et al.* (2007, \doi{10.1086/511864}) and the recommendations outlined in the [CLSI Guideline M39](https://clsi.org/standards/products/microbiology/documents/m39).
+#' The methodology implemented in these functions is strictly based on the recommendations outlined in [CLSI Guideline M39](https://clsi.org/standards/products/microbiology/documents/m39) and the research overview by Hindler *et al.* (2007, \doi{10.1086/511864}).
-
+#'
 #' To conduct epidemiological analyses on antimicrobial resistance data, only so-called first isolates should be included to prevent overestimation and underestimation of antimicrobial resistance. Different methods can be used to do so, see below.
 #'
 #' These functions are context-aware. This means that the `x` argument can be left blank if used inside a [data.frame] call, see *Examples*.
@@ -126,7 +126,7 @@
 #' @seealso [key_antimicrobials()]
 #' @export
 #' @return A [logical] vector
-#' @source Methodology of this function is strictly based on:
+#' @source Methodology of these functions is strictly based on:
 #'
 #' - **M39 Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data, 5th Edition**, 2022, *Clinical and Laboratory Standards Institute (CLSI)*. <https://clsi.org/standards/products/microbiology/documents/m39/>.
 #'

data-raw/_pre_commit_checks.R

@@ -402,13 +402,19 @@ pre_commit_lst$AB_FLUOROQUINOLONES <- antibiotics %>%
 pre_commit_lst$AB_GLYCOPEPTIDES <- antibiotics %>%
   filter(group %like% "glycopeptide") %>%
   pull(ab)
+pre_commit_lst$AB_ISOXAZOLYLPENICILLINS <- antibiotics %>%
+  filter(name %like% "oxacillin|cloxacillin|dicloxacillin|flucloxacillin|meth?icillin") %>%
+  pull(ab)
 pre_commit_lst$AB_LIPOGLYCOPEPTIDES <- as.ab(c("DAL", "ORI", "TLV")) # dalba/orita/tela
 pre_commit_lst$AB_GLYCOPEPTIDES_EXCEPT_LIPO <- pre_commit_lst$AB_GLYCOPEPTIDES[!pre_commit_lst$AB_GLYCOPEPTIDES %in% pre_commit_lst$AB_LIPOGLYCOPEPTIDES]
 pre_commit_lst$AB_LINCOSAMIDES <- antibiotics %>%
-  filter(atc_group2 %like% "lincosamide" | (group %like% "lincosamide" & is.na(atc_group2))) %>%
+  filter(atc_group2 %like% "lincosamide" | (group %like% "lincosamide" & is.na(atc_group2) & name %like% "^(pirlimycin)" & name %unlike% "screening|inducible")) %>%
   pull(ab)
 pre_commit_lst$AB_MACROLIDES <- antibiotics %>%
-  filter(atc_group2 %like% "macrolide" | (group %like% "macrolide" & is.na(atc_group2) & name %unlike% "screening|inducible")) %>%
+  filter(atc_group2 %like% "macrolide" | (group %like% "macrolide" & is.na(atc_group2) & name %like% "^(acetylmidecamycin|acetylspiramycin|gamith?romycin|kitasamycin|meleumycin|nafith?romycin|solith?romycin|tildipirosin|tilmicosin|tulath?romycin|tylosin|tylvalosin)" & name %unlike% "screening|inducible")) %>%
+  pull(ab)
+pre_commit_lst$AB_MONOBACTAMS <- antibiotics %>%
+  filter(group %like% "monobactam") %>%
   pull(ab)
 pre_commit_lst$AB_NITROFURANS <- antibiotics %>%
   filter(name %like% "^furaz|nitrofura" | atc_group2 %like% "nitrofuran") %>%
@@ -417,7 +423,7 @@ pre_commit_lst$AB_OXAZOLIDINONES <- antibiotics %>%
   filter(group %like% "oxazolidinone") %>%
   pull(ab)
 pre_commit_lst$AB_PENICILLINS <- antibiotics %>%
-  filter(group %like% "penicillin") %>%
+  filter(group %like% "penicillin" & !(name %unlike% "/" & name %like% ".*bactam$")) %>%
   pull(ab)
 pre_commit_lst$AB_PHENICOLS <- antibiotics %>%
   filter(group %like% "phenicol" | atc_group1 %like% "phenicol" | atc_group2 %like% "phenicol") %>%
@@ -442,7 +448,7 @@ pre_commit_lst$AB_TRIMETHOPRIMS <- antibiotics %>%
   filter(group %like% "trimethoprim") %>%
   pull(ab)
 pre_commit_lst$AB_UREIDOPENICILLINS <- as.ab(c("PIP", "TZP", "AZL", "MEZ"))
-pre_commit_lst$AB_BETALACTAMS <- c(pre_commit_lst$AB_PENICILLINS, pre_commit_lst$AB_CEPHALOSPORINS, pre_commit_lst$AB_CARBAPENEMS)
+pre_commit_lst$AB_BETALACTAMS <- sort(c(pre_commit_lst$AB_PENICILLINS, pre_commit_lst$AB_CEPHALOSPORINS, pre_commit_lst$AB_CARBAPENEMS, pre_commit_lst$AB_MONOBACTAMS))
 pre_commit_lst$AB_BETALACTAMS_WITH_INHIBITOR <- antibiotics %>%
   filter(name %like% "/" & name %unlike% "EDTA" & ab %in% pre_commit_lst$AB_BETALACTAMS) %>%
   pull(ab)

data-raw/ab.md5

@@ -1 +1 @@
-33a6626c9ac1ca6c5c13ad96588d11e5
+f946ff259f0e2cb1313508eab84bfd4c

data-raw/antibiotics.txt

@@ -3,15 +3,15 @@
 "ACM"	6450012	"Acetylmidecamycin"	"Macrolides/lincosamides"	"NA"			""	""					""
 "ASP"	49787020	"Acetylspiramycin"	"Macrolides/lincosamides"	"NA"			""	"foromacidinb,spiramycinii"					""
 "ALS"	8954	"Aldesulfone sodium"	"Other antibacterials"	"J04BA03"	"Drugs for treatment of lepra"	"Drugs for treatment of lepra"	""	"adesulfonesodium,aldapsone,aldesulfonasodica,aldesulfone,aldesulfonesodique,aldesulfonesodium,aldesulphonesodium,diamidin,diasone,diasonesodium,diazon,novotrone,sodiumaldesulphone,sodiumsulfoxone,sulfoxonesodium"	0.33	"g"			""
-"AMK"	37768	"Amikacin"	"Aminoglycosides"	"D06AX12,J01GB06,S01AA21"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"ak,ami,amik,amk,an"	"amicacin,amikacillin,amikacinbase,amikacindihydrate,amikacinfreebase,amikacinsulfate,amikacina,amikacine,amikacinum,amikavet,amikin,amiklin,amikozit,amukin,arikace,arikayceliposomal,briclin,kaminax,lukadin,mikavir,pierami,potentox"			1	"g"	"101493-5,11-7,12-5,13-3,13546-7,14-1,15098-7,17798-0,18860-7,20373-7,23624-0,25174-4,25175-1,25176-9,25177-7,25178-5,25179-3,31097-9,31098-7,31099-5,3319-1,3320-9,3321-7,35669-1,42642-9,48169-7,50802-8,50803-6,56628-1,59378-0,60564-2,60565-9,6975-7,80972-3,89484-0"
+"AMK"	37768	"Amikacin"	"Aminoglycosides"	"D06AX12,J01GB06,S01AA21"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"ak,ami,amik,amk,an"	"amicacin,amikacillin,amikacina,amikacinbase,amikacindihydrate,amikacine,amikacinfreebase,amikacinsulfate,amikacinum,amikavet,amikin,amiklin,amikozit,amukin,arikace,arikayceliposomal,briclin,kaminax,lukadin,mikavir,pierami,potentox"			1	"g"	"101493-5,11-7,12-5,13-3,13546-7,14-1,15098-7,17798-0,18860-7,20373-7,23624-0,25174-4,25175-1,25176-9,25177-7,25178-5,25179-3,31097-9,31098-7,31099-5,3319-1,3320-9,3321-7,35669-1,42642-9,48169-7,50802-8,50803-6,56628-1,59378-0,60564-2,60565-9,6975-7,80972-3,89484-0"
 "AKF"		"Amikacin/fosfomycin"	"Aminoglycosides"	"NA"			""	""					""
 "AMO"	54260	"Amorolfine"	"Antifungals/antimycotics"	"D01AE16"	"Antifungals for topical use"	"Other antifungals for topical use"	"amor"	"amorolfina,amorolfinum,loceryl"					""
-"AMX"	33613	"Amoxicillin"	"Beta-lactams/penicillins"	"J01CA04"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"ac,amox,amx"	"actimoxi,amoclen,amolin,amopen,amopenixin,amoxibiotic,amoxicaps,amoxicilina,amoxicillinhydrate,amoxicilline,amoxicillinum,amoxiden,amoxil,amoxivet,amoxy,amoxycillin,amoxyke,anemolin,aspenil,atoksilin,biomox,bristamox,cemoxin,clamoxyl,damoxy,delacillin,demoksil,dispermox,efpenix,flemoxin,hiconcil,histocillin,hydroxyampicillin,ibiamox,imacillin,lamoxy,largopen,metafarmacapsules,metifarmacapsules,moksilin,moxacin,moxatag,ospamox,pamoxicillin,piramox,promoxil,remoxil,robamox,sawamoxpm,tolodina,topramoxin,unicillin,utimox,vetramox"	1.5	"g"	3	"g"	"101498-4,15-8,16-6,16365-9,17-4,18-2,18861-5,18862-3,19-0,20-8,21-6,22-4,25274-2,25310-4,3344-9,55614-2,55615-9,55616-7,6976-5,6977-3,80133-2"
+"AMX"	33613	"Amoxicillin"	"Beta-lactams/penicillins"	"J01CA04"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"ac,amox,amx"	"actimoxi,amoclen,amolin,amopen,amopenixin,amoxibiotic,amoxicaps,amoxicilina,amoxicilline,amoxicillinhydrate,amoxicillinum,amoxiden,amoxil,amoxivet,amoxy,amoxycillin,amoxyke,anemolin,aspenil,atoksilin,biomox,bristamox,cemoxin,clamoxyl,damoxy,delacillin,demoksil,dispermox,efpenix,flemoxin,hiconcil,histocillin,hydroxyampicillin,ibiamox,imacillin,lamoxy,largopen,metafarmacapsules,metifarmacapsules,moksilin,moxacin,moxatag,ospamox,pamoxicillin,piramox,promoxil,remoxil,robamox,sawamoxpm,tolodina,topramoxin,unicillin,utimox,vetramox"	1.5	"g"	3	"g"	"101498-4,15-8,16-6,16365-9,17-4,18-2,18861-5,18862-3,19-0,20-8,21-6,22-4,25274-2,25310-4,3344-9,55614-2,55615-9,55616-7,6976-5,6977-3,80133-2"
-"AMC"	23665637	"Amoxicillin/clavulanic acid"	"Beta-lactams/penicillins"	"J01CR02"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	"a/c,amcl,aml,aug,xl"	"amocla,amoclan,amoclav,amoksiclav,amoxsiklav,amoxyclav,augmentan,augmentin,augmentinxr,augmentine,auspilic,clamentin,clamobit,clavamox,clavinex,clavoxilinplus,clavulin,clavumox,coamoxiclav,eumetinex,kmoxilin,spectramox,spektramox,synulox,viaclav,xiclav"	1.5	"g"	3	"g"	""
+"AMC"	23665637	"Amoxicillin/clavulanic acid"	"Beta-lactams/penicillins"	"J01CR02"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	"a/c,amcl,aml,aug,xl"	"amocla,amoclan,amoclav,amoksiclav,amoxsiklav,amoxyclav,augmentan,augmentin,augmentine,augmentinxr,auspilic,clamentin,clamobit,clavamox,clavinex,clavoxilinplus,clavulin,clavumox,coamoxiclav,eumetinex,kmoxilin,spectramox,spektramox,synulox,viaclav,xiclav"	1.5	"g"	3	"g"	""
 "AXS"	465441	"Amoxicillin/sulbactam"	"Beta-lactams/penicillins"	"NA"			""	""					"55614-2,55615-9,55616-7"
 "AMB"	5280965	"Amphotericin B"	"Antifungals/antimycotics"	"A01AB04,A07AA07,G01AA03,J02AA01"	"Antimycotics for systemic use"	"Antibiotics"	"amf,amfb,amph"	"abelcet,abelecet,ambisome,amfotericinab,amphocin,amphomoronal,amphortericinb,amphotec,amphotericin,amphotericinb,amphotericineb,amphotericinumb,amphozone,anfotericineb,fungilin,fungisome,fungisone,fungizone,halizon"	40	"mg"	210	"mg"	"16370-9,18863-1,23-2,24-0,25-7,26-5,3353-0,3354-8,40707-2,40757-7,49859-2,6978-1"
 "AMH"		"Amphotericin B-high"	"Antifungals/antimycotics"	"NA"			"amfo b high,amhl,ampho b high,amphotericin high"	""					""
-"AMP"	6249	"Ampicillin"	"Beta-lactams/penicillins"	"J01CA01,S01AA19"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"am,amp,ampi"	"acillin,adobacillin,amblosin,amcill,amfipen,amfipenv,amipenixs,ampichel,ampicil,ampicilina,ampicillina,ampicillinacid,ampicillinanhydrate,ampicillinanhydrous,ampicillinbase,ampicillinhydrate,ampicillinsodium,ampicilline,ampicillinum,ampicin,ampifarm,ampikel,ampimed,ampipenin,ampiscel,ampisyn,ampivax,ampivet,amplacilina,amplin,amplipenyl,amplisom,amplital,anhydrousampicillin,austrapen,binotal,bonapicillin,britacil,campicillin,copharcilin,delcillin,deripen,divercillin,doktacillin,duphacillin,grampenil,guicitrina,guicitrine,lifeampil,marcillin,morepen,norobrittin,nuvapen,olinkid,omnipen,orbicilina,penaoral,penampil,penbristol,penbritin,penbritinpaediatric,penbritinsyrup,penbrock,penicline,penimic,pensyn,pentrex,pentrexl,pentrexyl,pentritin,pfizerpena,polycillin,polyflex,ponecil,princillin,principen,qidamp,racenacillin,redicilin,rosampline,roscillin,semicillin,semicillinr,servicillin,sumipanto,synpenin,texcillin,tokiocillin,tolomol,totacillin,totalciclina,totapen,trifacilina,ukapen,ultrabion,ultrabron,vampen,viccillin,viccillins,vidocillin,wypicil"	2	"g"	6	"g"	"101477-8,101478-6,18864-9,18865-6,20374-5,21066-6,23618-2,27-3,28-1,29-9,30-7,31-5,32-3,33-1,3355-5,33562-0,33919-2,34-9,43883-8,43884-6,6979-9,6980-7,87604-5"
+"AMP"	6249	"Ampicillin"	"Beta-lactams/penicillins"	"J01CA01,S01AA19"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"am,amp,ampi"	"acillin,adobacillin,amblosin,amcill,amfipen,amfipenv,amipenixs,ampichel,ampicil,ampicilina,ampicillina,ampicillinacid,ampicillinanhydrate,ampicillinanhydrous,ampicillinbase,ampicilline,ampicillinhydrate,ampicillinsodium,ampicillinum,ampicin,ampifarm,ampikel,ampimed,ampipenin,ampiscel,ampisyn,ampivax,ampivet,amplacilina,amplin,amplipenyl,amplisom,amplital,anhydrousampicillin,austrapen,binotal,bonapicillin,britacil,campicillin,copharcilin,delcillin,deripen,divercillin,doktacillin,duphacillin,grampenil,guicitrina,guicitrine,lifeampil,marcillin,morepen,norobrittin,nuvapen,olinkid,omnipen,orbicilina,penampil,penaoral,penbristol,penbritin,penbritinpaediatric,penbritinsyrup,penbrock,penicline,penimic,pensyn,pentrex,pentrexl,pentrexyl,pentritin,pfizerpena,polycillin,polyflex,ponecil,princillin,principen,qidamp,racenacillin,redicilin,rosampline,roscillin,semicillin,semicillinr,servicillin,sumipanto,synpenin,texcillin,tokiocillin,tolomol,totacillin,totalciclina,totapen,trifacilina,ukapen,ultrabion,ultrabron,vampen,viccillin,viccillins,vidocillin,wypicil"	2	"g"	6	"g"	"101477-8,101478-6,18864-9,18865-6,20374-5,21066-6,23618-2,27-3,28-1,29-9,30-7,31-5,32-3,33-1,3355-5,33562-0,33919-2,34-9,43883-8,43884-6,6979-9,6980-7,87604-5"
 "SAM"	119561	"Ampicillin/sulbactam"	"Beta-lactams/penicillins"	"J01CR01"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	"a/s,ab,ams,amsu,apsu,sam"	"sulacillin"			6	"g"	"101478-6,18865-6,20374-5,23618-2,31-5,32-3,33-1,34-9,6980-7"
 "AMR"	73341	"Amprolium"	"Other antibacterials"	"QP51BX02"			""	"amprocidum,amprol,amprolio,amproliumchloride,amprovine,thiacoccid"					""
 "ANI"	166548	"Anidulafungin"	"Antifungals/antimycotics"	"J02AX06"	"Antimycotics for systemic use"	"Other antimycotics for systemic use"	"anid"	"anidulafungina,anidulafungine,anidulafunginum,ecalta,eraxis"			0.1	"g"	"55343-8,57095-2,58420-1,77162-6"
@@ -27,16 +27,16 @@
 "AZM"	447043	"Azithromycin"	"Macrolides/lincosamides"	"J01FA10,S01AA26"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"az,azi,azit,azm"	"aritromicina,aruzilina,azasite,azenil,azifast,azigram,azimakrol,azithramycine,azithrocin,azithromycine,azithromycinum,azitrocin,azitromax,azitromicina,azitromicine,azitromin,aziwin,aziwok,aztrin,azyter,azythromycin,durasite,hemomycin,macrozit,misultina,mixoterin,setron,sumamed,toraseptol,tromix,trozocina,trulimax,xithrone,zentavion,zithrax,zithromac,zithromax,zithromaxiv,zithromycin,zitrim,zitromax,zitrotek,zmaxsr,zythromax"	0.3	"g"	0.5	"g"	"100043-9,16420-2,16421-0,18866-4,23612-5,25233-8,35-6,36-4,37-2,38-0,6981-5,89480-8"
 "AFC"		"Azithromycin/fluconazole/secnidazole"	"Other antibacterials"	"J01RA07"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "AZL"	6479523	"Azlocillin"	"Beta-lactams/penicillins"	"J01CA09"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"az,azl,azlo"	"azlocilina,azlocilline,azlocillinum"			12	"g"	"16422-8,18867-2,3368-8,39-8,40-6,41-4,41661-0,42-2"
-"ATM"	5742832	"Aztreonam"	"Beta-lactams/penicillins"	"J01DF01"	"Other beta-lactam antibacterials"	"Monobactams"	"at,atm,azm,azt,aztr"	"azactam,azetreonam,azonam,azthreonam,aztreon,nebactam,primbactam"			4	"g"	"101497-6,16423-6,18868-0,25234-6,3369-6,41662-8,41663-6,41664-4,41727-9,43-0,44-8,45-5,46-3,6982-3"
+"ATM"	5742832	"Aztreonam"	"Monobactams"	"J01DF01"	"Other beta-lactam antibacterials"	"Monobactams"	"at,atm,azm,azt,aztr"	"azactam,azetreonam,azonam,azthreonam,aztreon,nebactam,primbactam"			4	"g"	"101497-6,16423-6,18868-0,25234-6,3369-6,41662-8,41663-6,41664-4,41727-9,43-0,44-8,45-5,46-3,6982-3"
-"AZA"		"Aztreonam/avibactam"	"Beta-lactams/penicillins"	"NA"			""	""					""
+"AZA"		"Aztreonam/avibactam"	"Monobactams"	"NA"			""	""					""
-"ANC"		"Aztreonam/nacubactam"	"Beta-lactams/penicillins"	"NA"			""	""					""
+"ANC"		"Aztreonam/nacubactam"	"Monobactams"	"NA"			""	""					""
 "BAM"	441397	"Bacampicillin"	"Beta-lactams/penicillins"	"J01CA06"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"bacampicilina,bacampicilline,bacampicillinum,penglobe"	1.2	"g"			"18869-8,47-1,48-9,49-7,50-5,55620-9"
 "BAC"	78358334	"Bacitracin"	"Other antibacterials"	"D06AX05,J01XX10,R02AB04,S01AA32"			"baci"	"fortracin,mdbacitracin"					"10868-8,16428-5,18870-6,6827-0,6983-1,87603-7"
 "BDQ"	5388906	"Bedaquiline"	"Other antibacterials"	"J04AK05"			""	"sirturo"	86	"mg"			"80637-2,88703-4,88704-2,94274-8,96107-8"
 "BEK"	439318	"Bekanamycin"	"Aminoglycosides"	"J01GB13"			""	"aminodeoxykanamycin,becanamicina,bekanamycine,bekanamycinum,kanamycinb,klebcil,nebramycinv"			0.6	"g"	""
 "BNB"		"Benzathine benzylpenicillin"	"Beta-lactams/penicillins"	"J01CE08"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	""	"beacillin,cepacilina,extencilline,lentopenil,penidural,tardocillin"			3.6	"g"	""
 "BNP"	64725	"Benzathine phenoxymethylpenicillin"	"Beta-lactams/penicillins"	"J01CE10"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	""	"bicillinv,biphecillin"	2	"g"			""
-"PEN"	5904	"Benzylpenicillin"	"Beta-lactams/penicillins"	"J01CE01,S01AA14"	"Combinations of antibacterials"	"Combinations of antibacterials"	"bepe,pen,peni,peni g,penicillin,penicillin g,pg"	"abbocillin,ayercillin,bencilpenicilina,benzopenicillin,benzylpenicilling,benzylpenicilline,benzylpenicillinum,bicillin,cillora,cilloral,cilopen,compocilling,cosmopen,dropcillin,freepenicilling,freepenicillinii,galofak,gelacillin,liquacillin,megacillin,pencilling,penicillin,penicilling,pentids,permapen,pfizerpen,pfizerpeng,pharmacillin,pradupen,specillineg,ursopen"			3.6	"g"	""
+"PEN"	5904	"Benzylpenicillin"	"Beta-lactams/penicillins"	"J01CE01,S01AA14"	"Combinations of antibacterials"	"Combinations of antibacterials"	"bepe,pen,peni,peni g,penicillin,penicillin g,pg"	"abbocillin,ayercillin,bencilpenicilina,benzopenicillin,benzylpenicilline,benzylpenicilling,benzylpenicillinum,bicillin,cillora,cilloral,cilopen,compocilling,cosmopen,dropcillin,freepenicilling,freepenicillinii,galofak,gelacillin,liquacillin,megacillin,pencilling,penicillin,penicilling,pentids,permapen,pfizerpen,pfizerpeng,pharmacillin,pradupen,specillineg,ursopen"			3.6	"g"	""
 "BES"	10178705	"Besifloxacin"	"Quinolones"	"S01AE08"			""	"besivance"					"73606-6,73628-0,73651-2"
 "BIA"	71339	"Biapenem"	"Carbapenems"	"J01DH05"			""	"biapenern,bipenem,omegacin"			1.2	"g"	"41665-1,41666-9,41667-7,41728-7"
 "BCZ"	65807	"Bicyclomycin"	"Other antibacterials"	"NA"			"bicozamycin"	"aizumycin,bacfeed,bacteron,bicozamicina,bicozamycin,bicozamycine,bicozamycinum"					""
@@ -47,19 +47,19 @@
 "CAP"	135565060	"Capreomycin"	"Antimycobacterials"	"J04AB30"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"capr"	""			1	"g"	"16545-6,18872-2,23607-5,25210-6,25211-4,25212-2,42643-7,48170-5,55-4,55623-3,56-2,57-0,58-8,61355-4,89483-2"
 "CRB"	20824	"Carbenicillin"	"Beta-lactams/penicillins"	"J01CA03"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"bar,carb,cb"	"anabactyl,carbenicilina,carbenicillina,carbenicilline,carbenicillinum,geopen,pyopen"			12	"g"	"18873-0,3434-8,41668-5,59-6,60-4,61-2,62-0"
 "CRN"	93184	"Carindacillin"	"Beta-lactams/penicillins"	"J01CA05"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"carindacilina,carindacilline,carindacillinum"	4	"g"			""
-"CAR"	6540466	"Carumonam"	"Other antibacterials"	"J01DF02"			""	"carumonamum"			2	"g"	"51694-8"
+"CAR"	6540466	"Carumonam"	"Monobactams"	"J01DF02"			""	"carumonamum"			2	"g"	"51694-8"
 "CAS"	2826718	"Caspofungin"	"Antifungals/antimycotics"	"J02AX04"	"Antimycotics for systemic use"	"Other antimycotics for systemic use"	"casp"	"cancidas,capsofungin"			50	"mg"	"32378-2,54175-5,54176-3,54185-4,58419-3"
 "CAC"	91562	"Cefacetrile"	"Cephalosporins (1st gen.)"	"J01DB10"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"cefacetril,cefacetrilo,cefacetrilum,celospor,celtol,cephacetrile,cristacef,vetrimast"					"55624-1,55625-8,55626-6,55627-4"
 "CEC"	51039	"Cefaclor"	"Cephalosporins (2nd gen.)"	"J01DC04"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"ccl,cec,cf,cfac,cfc,cfcl,cfr,fac"	"alenfral,alfacet,ceclor,ceclorcd,cefacloranhydrous,cefaclorimpurityc,cefaclormonohydrate,cefacloro,cefaclorum,cefeaclor,cephaclor,dystaclormr,keflor,kefral,panoral,raniclor"	1	"g"			"16564-7,18874-8,21149-0,6986-4,83-6,84-4,85-1,86-9"
 "CFR"	47965	"Cefadroxil"	"Cephalosporins (1st gen.)"	"J01DB05"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfdx,cfr,fad"	"anhydrouscefadroxil,cefadrops,cefadroxilanhydrous,cefadroxilo,cefadroxilum,cefradroxil,cephadroxil,duracef,duricef,sumacef,ultracef"	2	"g"			"16565-4,18875-5,55628-2,63-8,64-6,65-3,66-1"
-"LEX"	27447	"Cefalexin"	"Cephalosporins (1st gen.)"	"J01DB01"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cflx"	"alcephin,alexin,alsporin,amplex,anhydrouscefalexin,anhydrouscephalexin,biocef,carnosporin,cefablan,cefadal,cefadin,cefadina,cefaleksin,cefalessina,cefalexinanhydrous,cefalexina,cefalexine,cefalexinum,cefalin,cefaloto,cefaseptin,ceffanex,ceflax,ceforal,cefovit,celexin,cepastar,cepexin,cephacillin,cephalexin,cephalexinanhydrous,cephalexine,cephalexinum,cephanasten,cephaxin,cephin,ceporex,ceporexforte,ceporexin,ceporexine,cerexin,cerexins,cophalexin,durantel,durantelds,erocetin,factagard,felexin,ibilex,ibrexin,inphalex,kefalospes,keflet,keflex,kefolan,keforal,keftab,kekrinal,kidolex,lafarine,larixin,lenocef,lexibiotico,lonflex,lopilexin,madlexin,mamalexin,mamlexin,medoxine,neokef,neolexina,novolexin,optocef,oracef,oriphex,oroxin,ortisporina,ospexin,palitrex,panixinedisperdose,pectril,pyassan,roceph,rocephdistab,sanaxin,sartosona,sencephalin,sepexin,servispor,sialexin,sinthecillin,sporicef,sporidex,syncle,synecl,tepaxin,tokiolexin,uphalexin,voxxim,winlex,zozarine"	2	"g"			""
+"LEX"	27447	"Cefalexin"	"Cephalosporins (1st gen.)"	"J01DB01"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cflx"	"alcephin,alexin,alsporin,amplex,anhydrouscefalexin,anhydrouscephalexin,biocef,carnosporin,cefablan,cefadal,cefadin,cefadina,cefaleksin,cefalessina,cefalexina,cefalexinanhydrous,cefalexine,cefalexinum,cefalin,cefaloto,cefaseptin,ceffanex,ceflax,ceforal,cefovit,celexin,cepastar,cepexin,cephacillin,cephalexin,cephalexinanhydrous,cephalexine,cephalexinum,cephanasten,cephaxin,cephin,ceporex,ceporexforte,ceporexin,ceporexine,cerexin,cerexins,cophalexin,durantel,durantelds,erocetin,factagard,felexin,ibilex,ibrexin,inphalex,kefalospes,keflet,keflex,kefolan,keforal,keftab,kekrinal,kidolex,lafarine,larixin,lenocef,lexibiotico,lonflex,lopilexin,madlexin,mamalexin,mamlexin,medoxine,neokef,neolexina,novolexin,optocef,oracef,oriphex,oroxin,ortisporina,ospexin,palitrex,panixinedisperdose,pectril,pyassan,roceph,rocephdistab,sanaxin,sartosona,sencephalin,sepexin,servispor,sialexin,sinthecillin,sporicef,sporidex,syncle,synecl,tepaxin,tokiolexin,uphalexin,voxxim,winlex,zozarine"	2	"g"			""
 "RID"	5773	"Cefaloridine"	"Cephalosporins (1st gen.)"	"J01DB02"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cefa"	"aliporina,ampligram,cefaloridin,cefaloridina,cefaloridinum,cefalorizin,ceflorin,cepaloridin,cepalorin,cephalomycine,cephaloridin,cephaloridine,cephaloridinum,ceporan,ceporin,ceporine,cilifor,deflorin,faredina,floridin,glaxoridin,intrasporin,keflodin,keflordin,kefloridin,kefspor,lloncefal,loridine,sasperin,sefacin,verolgin,vioviantine"			3	"g"	""
 "CEP"	6024	"Cefalotin"	"Cephalosporins (1st gen.)"	"J01DB03"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfal,cflt"	"cefalothin,cefalotina,cefalotinafabra,cefalotine,cefalotinum,cemastin,cephalothinum,cephalotin,cephalotinacid,coaxin,keflin,seffin"			4	"g"	""
 "MAN"	456255	"Cefamandole"	"Cephalosporins (2nd gen.)"	"J01DC03"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cfam,cfmn"	"cefadole,cefamandol,cefamandolum,cephadole,cephamandole,kefamandol,kefdole,mancef"			6	"g"	"18876-3,3441-3,41669-3,55634-0,55635-7,55636-5,55637-3,67-9,68-7,69-5,70-3"
 "HAP"	30699	"Cefapirin"	"Cephalosporins (1st gen.)"	"J01DB08"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"ambrocef,cefadyl,cefapilin,cefapirina,cefapirine,cefapirinum,cefaprin,cefaprinsodium,cefatrex,cefatrexyl,cephapirine,metricure"			4	"g"	""
 "CTZ"	6410758	"Cefatrizine"	"Cephalosporins (1st gen.)"	"J01DB07"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"bricef,cefatrix,cefatrizino,cefatrizinum,cephatriazine,cepticol,cetrazil,latocef,orosporina,trizina"	1	"g"			"18877-1,55639-9,71-1,72-9,73-7,74-5"
 "CZD"	71736	"Cefazedone"	"Cephalosporins (1st gen.)"	"J01DB06"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"cefazedon,cefazedona,cefazedoneacid,cefazedonum,refosporen,refosporene,refosporin"			3	"g"	""
-"CZO"	33255	"Cefazolin"	"Cephalosporins (1st gen.)"	"J01DB04"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfz,cfzl,cz,czol,faz,kz"	"atirin,cefamezin,cefamezine,cefazina,cefazolinacid,cefazolina,cefazoline,cefazolinum,cephamezine,cephazolidin,cephazolin,cephazoline,elzogram,firmacef,kefzol,liviclina,totacef"			3	"g"	"16566-2,18878-9,25235-3,3442-1,3443-9,41670-1,75-2,76-0,77-8,78-6,80962-4,85422-4"
+"CZO"	33255	"Cefazolin"	"Cephalosporins (1st gen.)"	"J01DB04"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfz,cfzl,cz,czol,faz,kz"	"atirin,cefamezin,cefamezine,cefazina,cefazolina,cefazolinacid,cefazoline,cefazolinum,cephamezine,cephazolidin,cephazolin,cephazoline,elzogram,firmacef,kefzol,liviclina,totacef"			3	"g"	"16566-2,18878-9,25235-3,3442-1,3443-9,41670-1,75-2,76-0,77-8,78-6,80962-4,85422-4"
 "CFB"	127527	"Cefbuperazone"	"Other antibacterials"	"J01DC13"			""	"cefbuperazona,cefbuperazonum,cefbuperzaone,cerbuperazone,tomiporan"			2	"g"	""
 "CCP"	6436055	"Cefcapene"	"Cephalosporins (3rd gen.)"	"J01DD17"			""	"cefcamate"	0.45	"g"			"100044-7,76143-7"
 "CCX"	5282438	"Cefcapene pivoxil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefcamatepivoxil,cefcapenepiroxil"					""
@@ -67,11 +67,11 @@
 "DIT"	9870843	"Cefditoren"	"Cephalosporins (3rd gen.)"	"J01DD16"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cdn"	""	0.4	"g"			"35759-0,35760-8,35761-6,35762-4"
 "DIX"	6437877	"Cefditoren pivoxil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefditorenpivoxil,cefditorin,cefditorinpivoxil,meiact,spectracef"					""
 "FEP"	5479537	"Cefepime"	"Cephalosporins (4th gen.)"	"J01DE01"	"Other beta-lactam antibacterials"	"Fourth-generation cephalosporins"	"cfep,cfpi,cpe,cpm,fep,pm,xpm"	"axepim,cefepima,cefepimum,cepimax,cepimex,maxcef,maxipime"			4	"g"	"101502-3,18879-7,31142-3,31143-1,35763-2,38363-8,42350-9,42351-7,42353-3,50631-1,58412-8,6643-1,6644-9,6645-7,6646-5,6987-2,8272-7,8273-5"
-"CFA"		"Cefepime/amikacin"	"Other antibacterials"	"J01RA06"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
+"CFA"		"Cefepime/amikacin"	"Cephalosporins (4th gen.)"	"J01RA06"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "CPC"	9567559	"Cefepime/clavulanic acid"	"Cephalosporins (4th gen.)"	"NA"			"cicl,xpml"	""					""
-"FNC"		"Cefepime/nacubactam"	"Beta-lactams/penicillins"	"NA"			""	""					""
+"FNC"		"Cefepime/nacubactam"	"Cephalosporins (4th gen.)"	"NA"			""	""					""
 "FPT"	9567558	"Cefepime/tazobactam"	"Cephalosporins (4th gen.)"	"NA"			""	""					""
-"FPZ"		"Cefepime/zidebactam"	"Other antibacterials"	"NA"			""	""					""
+"FPZ"		"Cefepime/zidebactam"	"Cephalosporins (4th gen.)"	"NA"			""	""					""
 "CAT"	5487888	"Cefetamet"	"Cephalosporins (3rd gen.)"	"J01DD10"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	"cefetametum,cepimeo,deacetoxycefotaxime"	1	"g"			"32377-4,35764-0,35765-7,55640-7"
 "CPI"	5486182	"Cefetamet pivoxil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefetametpivoxyl,globocef"					""
 "CCL"	71719688	"Cefetecol"	"Cephalosporins (4th gen.)"	"NA"			"cefcatacol"	"cefetecolanhydrous"					""
@@ -88,7 +88,7 @@
 "CSL"		"Cefoperazone/sulbactam"	"Cephalosporins (3rd gen.)"	"J01DD62"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	""			4	"g"	"35768-1,54166-4,54167-2,54168-0"
 "CND"	43507	"Ceforanide"	"Cephalosporins (2nd gen.)"	"J01DC11"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	""	"ceforanido,ceforanidum,precef,radacef"			4	"g"	"103-2,104-0,105-7,106-5,18885-4,55643-1"
 "CSE"	9830519	"Cefoselis"	"Cephalosporins (4th gen.)"	"NA"			""	"cefoselissulfate,wincef,winsef"					""
-"CTX"	5742673	"Cefotaxime"	"Cephalosporins (3rd gen.)"	"J01DD01"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfot,cft,cftx,ct,ctx,fot,tax,xct"	"cefotaxim,cefotaximhikma,cefotaxima,cefotaximaacid,cefotaximeacid,cefotaximum,cephotaxime,claforan,omnatax"			4	"g"	"101479-4,101480-2,107-3,108-1,109-9,110-7,18886-2,25238-7,31138-1,31139-9,3446-2,35769-9,35770-7,35771-5,41671-9,50632-9,52128-6,54191-2,54192-0,54193-8,55189-5,55644-9,6989-8,80961-6"
+"CTX"	5742673	"Cefotaxime"	"Cephalosporins (3rd gen.)"	"J01DD01"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfot,cft,cftx,ct,ctx,fot,tax,xct"	"cefotaxim,cefotaxima,cefotaximaacid,cefotaximeacid,cefotaximhikma,cefotaximum,cephotaxime,claforan,omnatax"			4	"g"	"101479-4,101480-2,107-3,108-1,109-9,110-7,18886-2,25238-7,31138-1,31139-9,3446-2,35769-9,35770-7,35771-5,41671-9,50632-9,52128-6,54191-2,54192-0,54193-8,55189-5,55644-9,6989-8,80961-6"
 "CTC"	9575353	"Cefotaxime/clavulanic acid"	"Cephalosporins (3rd gen.)"	"NA,J01DD51"			"cxcl,xctl"	""					""
 "CTS"	9574753	"Cefotaxime/sulbactam"	"Cephalosporins (3rd gen.)"	"NA"			""	""					"54191-2,54192-0,54193-8,55644-9"
 "CTT"	53025	"Cefotetan"	"Cephalosporins (2nd gen.)"	"J01DC05"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cftt,cn,cte,ctn,ctt,tans"	"apacef,cefotan,cefotetanacid,cefotetanfreeacid,cefotetanum"			4	"g"	"111-5,112-3,113-1,114-9,18887-0,25239-5,3447-0,41672-7,41673-5,41674-3,41729-5,6990-6"
@@ -101,7 +101,7 @@
 "CFZ"	68597	"Cefpimizole"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefpimizol,cefpimizolesodium,cefpimizolum"					""
 "CPM"	636405	"Cefpiramide"	"Cephalosporins (3rd gen.)"	"J01DD11"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	"cefpiramideacid,cefpiramido,cefpiramidum"			2	"g"	""
 "CPO"	5479539	"Cefpirome"	"Cephalosporins (4th gen.)"	"J01DE02"	"Other beta-lactam antibacterials"	"Fourth-generation cephalosporins"	"cfpr"	"broact,cefpiroma,cefpiromum,cefrom,cerfpirome,keiten"			4	"g"	"18889-6,6647-3,6648-1,6649-9,6650-6,6992-2,8274-3,8275-0,8276-8"
-"CPD"	6335986	"Cefpodoxime"	"Cephalosporins (3rd gen.)"	"J01DD13"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfpd,cfpo,cpd,pod,px"	"cefpodoximacid,cefpodoxima,cefpodoximeacid,cefpodoximum,epoxim"	0.4	"g"			"119-8,120-6,121-4,122-2,18890-4,25241-1,41678-4,41679-2,41680-0,41731-1,6993-0,90849-1"
+"CPD"	6335986	"Cefpodoxime"	"Cephalosporins (3rd gen.)"	"J01DD13"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfpd,cfpo,cpd,pod,px"	"cefpodoxima,cefpodoximacid,cefpodoximeacid,cefpodoximum,epoxim"	0.4	"g"			"119-8,120-6,121-4,122-2,18890-4,25241-1,41678-4,41679-2,41680-0,41731-1,6993-0,90849-1"
 "CPX"	6526396	"Cefpodoxime proxetil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefodox,cefoprox,cefpodoximeproxetil,cepodem,orelox,oreloxpaed,otreon,podomexef,simplicef,vantin"					""
 "CDC"		"Cefpodoxime/clavulanic acid"	"Cephalosporins (3rd gen.)"	"NA"			"cecl"	""					""
 "CPR"	5281006	"Cefprozil"	"Cephalosporins (2nd gen.)"	"J01DC10"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cpr,cpz,fp"	"arzimol,brisoral,cefprozilanhydrous,cefprozilhydrate,cefprozilo,cefprozilum,cefzil,cronocef,procef,serozil"	1	"g"			"123-0,124-8,125-5,126-3,18891-2,6994-8"
@@ -117,7 +117,7 @@
 "CEM"	6537431	"Cefteram"	"Cephalosporins (3rd gen.)"	"J01DD18"			""	"cefterame,cefteramum,ceftetrame"	0.4	"g"			"100047-0,76144-5"
 "CPL"	5362114	"Cefteram pivoxil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefterampivoxil,tomiron"					""
 "CTL"	65755	"Ceftezole"	"Cephalosporins (1st gen.)"	"J01DB12"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"ceftezol,ceftezolo,ceftezolum,demethylcefazolin"			3	"g"	""
-"CTB"	5282242	"Ceftibuten"	"Cephalosporins (3rd gen.)"	"J01DD14"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cb,cfbu,ctb,tib"	"ceftem,ceftibutendihydrate,ceftibutenhydrate,ceftibutene,ceftibuteno,ceftibutenum,ceftibutin,cephem,ceprifran,isocef,keimax"	0.4	"g"			"35777-2,35778-0,35779-8,6996-3"
+"CTB"	5282242	"Ceftibuten"	"Cephalosporins (3rd gen.)"	"J01DD14"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cb,cfbu,ctb,tib"	"ceftem,ceftibutendihydrate,ceftibutene,ceftibutenhydrate,ceftibuteno,ceftibutenum,ceftibutin,cephem,ceprifran,isocef,keimax"	0.4	"g"			"35777-2,35778-0,35779-8,6996-3"
 "TIO"	6328657	"Ceftiofur"	"Cephalosporins (3rd gen.)"	"QJ01DD90,QJ51DD90"			""	"ceftiofurum,excede,excenel,naxcel"					"23709-9,35780-6,35781-4,55652-2"
 "CZX"	6533629	"Ceftizoxime"	"Cephalosporins (3rd gen.)"	"J01DD07"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfzx,ctz,cz,czx,tiz,zox"	"cefizox,ceftisomin,ceftix,ceftizoxima,ceftizoximum,epocelin,eposerin"			4	"g"	"136-2,137-0,138-8,139-6,18894-6,20378-6,23622-4,25243-7,3450-4,6997-1"
 "CZP"	9578661	"Ceftizoxime alapivoxil"	"Cephalosporins (3rd gen.)"	"NA"			""	""					""
@@ -129,15 +129,15 @@
 "CXM"	5479529	"Cefuroxime"	"Cephalosporins (2nd gen.)"	"J01DC02,S01AA27"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cfrx,cfur,cfx,crm,cxm,fur,rox,xm"	"biofuroksym,cefuril,cefuroxim,cefuroxima,cefuroximeacid,cefuroximine,cefuroximo,cefuroximum,cephuroxime,kefurox,sharox,zinacef,zinacefdanmark"	0.5	"g"	3	"g"	"101503-1,144-6,145-3,146-1,147-9,18896-1,20460-2,25245-2,3452-0,35782-2,35783-0,51724-3,51774-8,55653-0,55654-8,6999-7,74699-0,80608-3,80617-4"
 "CXA"	6321416	"Cefuroxime axetil"	"Cephalosporins (2nd gen.)"	"NA"			"cfax"	"altacef,bioracef,cefaks,cefazine,ceftin,cefurax,cefuroximaxetil,cefuroximeaxetil,celocid,cepazine,cethixim,cetoxil,coliofossim,elobact,forcef,furoxime,kalcef,maxitil,medoxm,nivador,novador,novocef,oraxim,zinnat"					""
 "CFM2"		"Cefuroxime/metronidazole"	"Other antibacterials"	"J01RA03"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
-"ZON"	6336505	"Cefuzonam"	"Other antibacterials"	"NA"			""	"cefuzonamsodium,cefuzoname,cefuzonamum"					""
+"ZON"	6336505	"Cefuzonam"	"Other antibacterials"	"NA"			""	"cefuzoname,cefuzonamsodium,cefuzonamum"					""
 "CED"	38103	"Cephradine"	"Cephalosporins (1st gen.)"	"J01DB09"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfra,cfrd"	"anspor,cefradin,cefradina,cefradine,cefradinehydrate,cefradinum,cekodin,cephradin,cephradineanhydrous,cephradinehydrate,eskacef,infexin,megacef,sefril,velocef,velosef"	2	"g"	2	"g"	"168-5,169-3,170-1,171-9,18902-7,55646-4"
 "CTO"	71402	"Cetocycline"	"Tetracyclines"	"NA"			""	"cetocyline,cetotetrine,chelocardin"					""
-"CHL"	5959	"Chloramphenicol"	"Phenicols"	"D06AX02,D10AF03,G01AA05,J01BA01,S01AA01,S02AA01,S03AA08"	"Amphenicols"	"Amphenicols"	"c,chl,chlo,cl"	"alficetyn,ambofen,amphenicol,amphicol,amseclor,anacetin,aquamycetin,austracil,austracol,biocetin,biophenicol,catilan,chloramex,chemiceticol,chemicetin,chemicetina,chlomin,chlomycol,chloramfenikol,chloramficin,chloramfilin,chloramphenicole,chloramphenicolum,chloramsaar,chlorasol,chlorbiotic,chloricol,chlormycetinr,chlornitromycin,chloroamphenicol,chlorocaps,chlorocid,chlorocids,chlorocide,chlorocidinc,chlorocidinctetran,chlorocin,chlorocol,chlorofair,chlorojectl,chloromax,chloromycetin,chloromycetny,chloromyxin,chloronitrin,chloroptic,chloropticsop,chlorovules,chlorsig,cidocetine,ciplamycetin,cloramfen,cloramfenicol,cloramfenicolo,cloramficin,cloramical,cloramicol,cloramidina,cloranfenicol,cloroamfenicolo,clorocyn,cloromisan,cloromissan,clorosintex,comycetin,cylphenicol,desphen,detreomycin,detreomycine,dextromycetin,doctamicina,duphenicol,econochlor,embacetin,emetren,enicol,enteromycetin,erbaplast,ertilen,farmicetina,fenicol,globenicol,glorous,gloveticol,halcetin,halomycetin,hortfenicol,interomycetine,intramycetin,intramyctin,isicetin,ismicetina,isophenicol,isoptofenicol,juvamycetin,kamaver,kemicetina,kemicetine,kloramfenikol,klorita,klorocids,laevomycetinum,leukamycin,leukomyan,leukomycin,levocin,levomicetina,levomitsetin,levomycetin,levoplast,levosin,levovetin,loromicetina,loromisan,loromisin,mastiphen,mediamycetine,medichol,micloretin,micochlorine,micoclorina,microcetina,mychel,mycinol,myclocin,mycochlorin,myscel,normimycinv,novochlorocap,novomycetin,novophenicol,ocuphenicol,oftalent,oleomycetin,opclor,opelor,ophthochlor,ophthocort,ophtochlor,optomycin,otachron,otophen,pantovernil,paraxin,pentamycetin,quemicetina,rivomycin,romphenil,ronfenil,ronphenil,septicol,sificetina,sintomicetin,sintomicetina,sintomicetiner,snophenicol,soluthor,stanomycetin,synthomycetin,synthomycetine,synthomycine,syntomycin,tevcocin,tevcosin,tifomycin,tifomycine,tiromycetin,treomicetina,tyfomycine,unimycetin,veticol,viceton"	3	"g"	3	"g"	"15101-9,16603-3,16604-1,172-7,173-5,174-3,175-0,18903-5,25247-8,29214-4,29346-4,29347-2,3455-3,7001-1"
+"CHL"	5959	"Chloramphenicol"	"Phenicols"	"D06AX02,D10AF03,G01AA05,J01BA01,S01AA01,S02AA01,S03AA08"	"Amphenicols"	"Amphenicols"	"c,chl,chlo,cl"	"alficetyn,ambofen,amphenicol,amphicol,amseclor,anacetin,aquamycetin,austracil,austracol,biocetin,biophenicol,catilan,chemiceticol,chemicetin,chemicetina,chlomin,chlomycol,chloramex,chloramfenikol,chloramficin,chloramfilin,chloramphenicole,chloramphenicolum,chloramsaar,chlorasol,chlorbiotic,chloricol,chlormycetinr,chlornitromycin,chloroamphenicol,chlorocaps,chlorocid,chlorocide,chlorocidinc,chlorocidinctetran,chlorocids,chlorocin,chlorocol,chlorofair,chlorojectl,chloromax,chloromycetin,chloromycetny,chloromyxin,chloronitrin,chloroptic,chloropticsop,chlorovules,chlorsig,cidocetine,ciplamycetin,cloramfen,cloramfenicol,cloramfenicolo,cloramficin,cloramical,cloramicol,cloramidina,cloranfenicol,cloroamfenicolo,clorocyn,cloromisan,cloromissan,clorosintex,comycetin,cylphenicol,desphen,detreomycin,detreomycine,dextromycetin,doctamicina,duphenicol,econochlor,embacetin,emetren,enicol,enteromycetin,erbaplast,ertilen,farmicetina,fenicol,globenicol,glorous,gloveticol,halcetin,halomycetin,hortfenicol,interomycetine,intramycetin,intramyctin,isicetin,ismicetina,isophenicol,isoptofenicol,juvamycetin,kamaver,kemicetina,kemicetine,kloramfenikol,klorita,klorocids,laevomycetinum,leukamycin,leukomyan,leukomycin,levocin,levomicetina,levomitsetin,levomycetin,levoplast,levosin,levovetin,loromicetina,loromisan,loromisin,mastiphen,mediamycetine,medichol,micloretin,micochlorine,micoclorina,microcetina,mychel,mycinol,myclocin,mycochlorin,myscel,normimycinv,novochlorocap,novomycetin,novophenicol,ocuphenicol,oftalent,oleomycetin,opclor,opelor,ophthochlor,ophthocort,ophtochlor,optomycin,otachron,otophen,pantovernil,paraxin,pentamycetin,quemicetina,rivomycin,romphenil,ronfenil,ronphenil,septicol,sificetina,sintomicetin,sintomicetina,sintomicetiner,snophenicol,soluthor,stanomycetin,synthomycetin,synthomycetine,synthomycine,syntomycin,tevcocin,tevcosin,tifomycin,tifomycine,tiromycetin,treomicetina,tyfomycine,unimycetin,veticol,viceton"	3	"g"	3	"g"	"15101-9,16603-3,16604-1,172-7,173-5,174-3,175-0,18903-5,25247-8,29214-4,29346-4,29347-2,3455-3,7001-1"
 "CTE"	54675777	"Chlortetracycline"	"Tetracyclines"	"A01AB21,D06AA02,J01AA03,S01AA02"	"Tetracyclines"	"Tetracyclines"	""	"acronize,aueromycin,aureocina,aureomycin,aureomykoin,biomitsin,biomycin,biomycina,chlormax,chlorotetracycline,chlortetracyclinum,chrysomykine,clortetraciclina,duomycin,flamycin,uromycin"	1	"g"			"176-8,177-6,178-4,179-2,18904-3,55655-5,87600-3"
 "CIC"	19003	"Ciclacillin"	"Beta-lactams/penicillins"	"NA"			""	"bastcillin,calthor,ciclacilina,ciclacilline,ciclacillinum,ciclacillum,citosarin,cyclacillin,cyclapen,noblicil,orfilina,peamezin,syngacillin,ultracillin,vastcillin,vipicil,wyvital"					""
 "CIX"	47472	"Ciclopirox"	"Antifungals/antimycotics"	"D01AE14,G01AX12"	"Antifungals for topical use"	"Other antifungals for topical use"	"cipx"	"butaconazole,butoconazol,butoconazolum,ciclodan,ciclopiroxgel,ciclopiroxolamin,ciclopiroxum,compositenstarke,dahlin,femstat,gynofort,loprox,loproxcream,loproxgel,penlac,polyfructosanum,stieprox"					""
 "CIN"	2762	"Cinoxacin"	"Quinolones"	"J01MB06"	"Quinolone antibacterials"	"Other quinolones"	"cino,cnox"	"azolinicacid,cinobac,cinobactin,cinoxacine,cinoxacino,cinoxacinum,clinoxacin,noxigram,uronorm"	1	"g"			"180-0,181-8,182-6,183-4,18905-0,55656-3"
-"CIP"	2764	"Ciprofloxacin"	"Quinolones"	"J01MA02,S01AE03,S02AA15,S03AA07"	"Quinolone antibacterials"	"Fluoroquinolones"	"ci,cip,cipr,cp"	"alconcilox,auripro,bacquinor,baflox,baycip,bernoflox,cetraxal,ciflox,cifloxin,ciloxan,ciplus,ciprecu,ciprine,ciprinol,ciproiv,ciproxl,ciproxr,ciprobay,ciprobayuro,ciprocinol,ciprodar,ciproflox,ciprofloxacina,ciprofloxacine,ciprofloxacino,ciprofloxacinum,ciprogis,ciprolin,ciprolon,cipromycin,ciproquinol,ciprowin,ciproxan,ciproxin,ciproxina,ciproxine,ciriax,citopcin,corsacin,cyprobay,fimoflox,flociprin,ipiflox,italnik,linhaliq,otiprio,probiox,proflaxin,quinolid,quintor,rancif,roxytal,septicide,sophixinofteno,spitacin,superocin,velmonit,velomonit,zumaflox"	1	"g"	0.8	"g"	"101500-7,14031-9,14032-7,14058-2,14059-0,184-2,185-9,186-7,187-5,18906-8,20377-8,23621-6,25180-1,25181-9,25188-4,25189-2,25248-6,34636-1,3484-3,42644-5,55194-5,7002-9"
+"CIP"	2764	"Ciprofloxacin"	"Quinolones"	"J01MA02,S01AE03,S02AA15,S03AA07"	"Quinolone antibacterials"	"Fluoroquinolones"	"ci,cip,cipr,cp"	"alconcilox,auripro,bacquinor,baflox,baycip,bernoflox,cetraxal,ciflox,cifloxin,ciloxan,ciplus,ciprecu,ciprine,ciprinol,ciprobay,ciprobayuro,ciprocinol,ciprodar,ciproflox,ciprofloxacina,ciprofloxacine,ciprofloxacino,ciprofloxacinum,ciprogis,ciproiv,ciprolin,ciprolon,cipromycin,ciproquinol,ciprowin,ciproxan,ciproxin,ciproxina,ciproxine,ciproxl,ciproxr,ciriax,citopcin,corsacin,cyprobay,fimoflox,flociprin,ipiflox,italnik,linhaliq,otiprio,probiox,proflaxin,quinolid,quintor,rancif,roxytal,septicide,sophixinofteno,spitacin,superocin,velmonit,velomonit,zumaflox"	1	"g"	0.8	"g"	"101500-7,14031-9,14032-7,14058-2,14059-0,184-2,185-9,186-7,187-5,18906-8,20377-8,23621-6,25180-1,25181-9,25188-4,25189-2,25248-6,34636-1,3484-3,42644-5,55194-5,7002-9"
 "CIM"		"Ciprofloxacin/metronidazole"	"Quinolones"	"J01RA10"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "CIO"		"Ciprofloxacin/ornidazole"	"Quinolones"	"J01RA12"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "CIT"		"Ciprofloxacin/tinidazole"	"Quinolones"	"J01RA11"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
@@ -150,24 +150,24 @@
 "CLF1"	2799	"Clofoctol"	"Other antibacterials"	"J01XX03"	"Other antibacterials"	"Other antibacterials"	""	"clofoctolo,clofoctolum,gramplus,octofene"					""
 "CLM"	71807	"Clometocillin"	"Beta-lactams/penicillins"	"J01CE07"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	""	"chlomethocillin,clometacillin,clometocilina,clometocilline,clometocillinum,rixapen"	1	"g"			""
 "CLM1"	54680675	"Clomocycline"	"Tetracyclines"	"J01AA11"	"Tetracyclines"	"Tetracyclines"	""	"chlormethylencycline,clomociclina,clomocyclin,clomocyclinum,megaclor"	1	"g"			""
-"CTR"	2812	"Clotrimazole"	"Antifungals/antimycotics"	"A01AB18,D01AC01,G01AF02"			"clot"	"canesten,canestencream,canestensolution,canestene,canestine,canifug,chlotrimazole,cimitidine,clomatin,clotrimaderm,clotrimadermcream,clotrimazol,clotrimazolum,cutistad,desamixf,diphenylmethane,empecid,esparol,femcare,gynelotrimin,jidesheng,kanesten,klotrimazole,lotrimax,lotrimin,lotriminaf,lotriminafcream,lotriminaflotion,lotriminafsolution,lotrimincream,lotriminlotion,lotriminsolution,monobaycuten,mycelax,mycelex,mycelexcream,mycelexg,mycelexotc,mycelexsolution,mycelextroches,mycelextwinpack,myclocream,myclosolution,myclospraysolution,mycofug,mycosporin,mykosporin,nalbix,otomax,pedisafe,rimazole,stiemazol,tibatin,trimysten,trivagizole,veltrim"					"10653-4,10654-2,18909-2,54177-1,55663-9"
+"CTR"	2812	"Clotrimazole"	"Antifungals/antimycotics"	"A01AB18,D01AC01,G01AF02"			"clot"	"canesten,canestencream,canestene,canestensolution,canestine,canifug,chlotrimazole,cimitidine,clomatin,clotrimaderm,clotrimadermcream,clotrimazol,clotrimazolum,cutistad,desamixf,diphenylmethane,empecid,esparol,femcare,gynelotrimin,jidesheng,kanesten,klotrimazole,lotrimax,lotrimin,lotriminaf,lotriminafcream,lotriminaflotion,lotriminafsolution,lotrimincream,lotriminlotion,lotriminsolution,monobaycuten,mycelax,mycelex,mycelexcream,mycelexg,mycelexotc,mycelexsolution,mycelextroches,mycelextwinpack,myclocream,myclosolution,myclospraysolution,mycofug,mycosporin,mykosporin,nalbix,otomax,pedisafe,rimazole,stiemazol,tibatin,trimysten,trivagizole,veltrim"					"10653-4,10654-2,18909-2,54177-1,55663-9"
-"CLO"	6098	"Cloxacillin"	"Beta-lactams/penicillins"	"J01CF02"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"clox"	"chloroxacillin,clossacillina,cloxacilina,cloxacillinsodium,cloxacilline,cloxacillinna,cloxacillinum,cloxapen,methocillins,orbenin,syntarpen,tegopen"	2	"g"	2	"g"	"16628-0,18910-0,196-6,197-4,198-2,199-0,25250-2,55664-7"
+"CLO"	6098	"Cloxacillin"	"Beta-lactams/penicillins"	"J01CF02"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"clox"	"chloroxacillin,clossacillina,cloxacilina,cloxacilline,cloxacillinna,cloxacillinsodium,cloxacillinum,cloxapen,methocillins,orbenin,syntarpen,tegopen"	2	"g"	2	"g"	"16628-0,18910-0,196-6,197-4,198-2,199-0,25250-2,55664-7"
 "COL"	5311054	"Colistin"	"Polymyxins"	"A07AA10,J01XB01"	"Other antibacterials"	"Polymyxins"	"cl,coli,cs,cst,ct"	"belcomycine,colimycin,colimycinsulphate,colisticin,colistimethate,colistimethatesodium,colistinsulfate,colistinsulphate,colobreathe,colomycin,colymycin,polymyxine,polymyxinesulfate,promixin,totazina"	9	"MU"	9	"MU"	"16645-4,18912-6,204-8,205-5,206-3,207-1,29493-4,33333-6"
 "COP"		"Colistin/polysorbate"	"Other antibacterials"	"NA"			""	""					""
 "CYC"	6234	"Cycloserine"	"Oxazolidinones"	"J04AB01"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"cycl"	"cicloserina,closerin,closina,cyclorin,cycloserin,cycloserinum,farmiserina,micoserina,miroserina,miroseryn,novoserin,oxamicina,oxamycin,seromycin,tebemicina,tisomycin,wasserina"	0.75	"g"			"16702-3,18914-2,212-1,213-9,214-7,215-4,23608-3,25207-2,25208-0,25209-8,25251-0,3519-6,55667-0"
 "DAL"	23724878	"Dalbavancin"	"Glycopeptides"	"J01XA04"	"Other antibacterials"	"Glycopeptide antibacterials"	"dalb"	"dalvance"			1.5	"g"	"41688-3,41689-1,41690-9,41734-5"
 "DAN"	71335	"Danofloxacin"	"Quinolones"	"QJ01MA92"			""	"advocin,danofloxacine,danofloxacino,danofloxacinum"					"73601-7,73623-1,73646-2"
-"DPS"	2955	"Dapsone"	"Other antibacterials"	"D10AX05,J04BA02"	"Drugs for treatment of lepra"	"Drugs for treatment of lepra"	""	"aczone,aralditeht,atrisone,avlosulfon,avlosulfone,avlosulphone,avsulfor,bissulfone,bissulphone,croysulfone,croysulphone,dapson,dapsona,dapsonum,disulfone,diaphenylsulfone,diaphenylsulfon,diaphenylsulphon,diaphenylsulphone,dimitone,diphenasone,diphone,disulone,disulphone,dubronax,dubronaz,dumitone,eporal,metabolitec,novophone,protogen,servidapson,slphadione,sulfadione,sulfona,sulfoneucb,sulfonyldianiline,sulphadione,sulphonyldianiline,sumicures,tarimyl,udolac"	50	"mg"			"51698-9,9747-7"
+"DPS"	2955	"Dapsone"	"Other antibacterials"	"D10AX05,J04BA02"	"Drugs for treatment of lepra"	"Drugs for treatment of lepra"	""	"aczone,aralditeht,atrisone,avlosulfon,avlosulfone,avlosulphone,avsulfor,bissulfone,bissulphone,croysulfone,croysulphone,dapson,dapsona,dapsonum,diaphenylsulfon,diaphenylsulfone,diaphenylsulphon,diaphenylsulphone,dimitone,diphenasone,diphone,disulfone,disulone,disulphone,dubronax,dubronaz,dumitone,eporal,metabolitec,novophone,protogen,servidapson,slphadione,sulfadione,sulfona,sulfoneucb,sulfonyldianiline,sulphadione,sulphonyldianiline,sumicures,tarimyl,udolac"	50	"mg"			"51698-9,9747-7"
 "DAP"	16134395	"Daptomycin"	"Other antibacterials"	"J01XX09"	"Other antibacterials"	"Other antibacterials"	"dap,dapt"	"cidecin,cubicin,dapcin,daptomicina,daptomycine,daptomycinum"			0.28	"g"	"35787-1,35788-9,35789-7,41691-7"
 "DFX"	487101	"Delafloxacin"	"Quinolones"	"J01MA23"			""	"baxdela,delafloxacinum,quofenix"	0.9	"g"	0.6	"g"	"88885-9,90447-4,93790-4"
 "DLM"	6480466	"Delamanid"	"Antimycobacterials"	"J04AK06"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"dela"	"deltyba"	0.2	"g"			"93851-4,96109-4"
 "DEM"	54680690	"Demeclocycline"	"Tetracyclines"	"D06AA01,J01AA01"	"Tetracyclines"	"Tetracyclines"	""	"bioterciclin,clortetrin,declomycin,deganol,demeclociclina,demeclocyclinum,demeclor,demetraclin,diuciclin,elkamicina,ledermycin,mexocine,novotriclina,perciclina,sumaclina"	0.6	"g"			"10982-7,18915-9,216-2,217-0,218-8,219-6,29494-2,7006-0"
-"DKB"	470999	"Dibekacin"	"Aminoglycosides"	"J01GB09,S01AA29"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	""	"debecacin,dibekacinsulfate,dibekacina,dibekacine,dibekacinum,dideoxykanamycinb,kappati,orbicin,panamicin"			0.14	"g"	"55669-6,55670-4,55671-2,55672-0"
+"DKB"	470999	"Dibekacin"	"Aminoglycosides"	"J01GB09,S01AA29"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	""	"debecacin,dibekacina,dibekacine,dibekacinsulfate,dibekacinum,dideoxykanamycinb,kappati,orbicin,panamicin"			0.14	"g"	"55669-6,55670-4,55671-2,55672-0"
-"DIC"	18381	"Dicloxacillin"	"Beta-lactams/penicillins"	"J01CF01"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"dicl"	"dichloroxacillin,diclossacillina,dicloxaciclin,dicloxacilin,dicloxacilina,dicloxacillinsodium,dicloxacillina,dicloxacilline,dicloxacillinum,dicloxacycline,dycill,dynapen,maclicine,nmdicloxacillin,pathocil"	2	"g"	2	"g"	"10984-3,16769-2,18916-7,220-4,221-2,222-0,223-8,25252-8,32380-8,55668-8"
+"DIC"	18381	"Dicloxacillin"	"Beta-lactams/penicillins"	"J01CF01"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"dicl"	"dichloroxacillin,diclossacillina,dicloxaciclin,dicloxacilin,dicloxacilina,dicloxacillina,dicloxacilline,dicloxacillinsodium,dicloxacillinum,dicloxacycline,dycill,dynapen,maclicine,nmdicloxacillin,pathocil"	2	"g"	2	"g"	"10984-3,16769-2,18916-7,220-4,221-2,222-0,223-8,25252-8,32380-8,55668-8"
 "DIF"	56206	"Difloxacin"	"Quinolones"	"QJ01MA94"			""	"dicural,pulsaflox"					"35790-5,35791-3,35792-1"
 "DIR"	6473883	"Dirithromycin"	"Macrolides/lincosamides"	"J01FA13"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"dirithromycine,dirithromycinum,diritromicina,divitross,dynabac,noriclan,valodin"	0.5	"g"			"35793-9,35794-7,35795-4,7007-8"
 "DOR"	73303	"Doripenem"	"Carbapenems"	"J01DH04"	"Other beta-lactam antibacterials"	"Carbapenems"	"dori"	"doribax,doripenemhydrate,finibax"			1.5	"g"	"56031-8,58711-3,60535-2,72893-1"
-"DOX"	54671203	"Doxycycline"	"Tetracyclines"	"A01AB22,J01AA02"	"Tetracyclines"	"Tetracyclines"	"dox,doxy"	"atridox,azudoxat,deoxymykoin,dossiciclina,doxcyclineanhydrous,doxiciclina,doxirobe,doxitard,doxivetin,doxycen,doxychel,doxycin,doxycyclin,doxycyclinecalcium,doxycyclinehyclate,doxycyclinum,doxylin,doxysol,doxytec,doxytetracycline,hydramycin,investin,jenacyclin,liviatin,monodox,oracea,periostat,ronaxan,spanor,supracyclin,vibramycin,vibramycinnovum,vibramycine,vibravenos,zenavod"	0.1	"g"	0.1	"g"	"10986-8,18917-5,20379-4,21250-6,224-6,225-3,226-1,227-9,23623-2,25223-9,26902-7,7008-6"
+"DOX"	54671203	"Doxycycline"	"Tetracyclines"	"A01AB22,J01AA02"	"Tetracyclines"	"Tetracyclines"	"dox,doxy"	"atridox,azudoxat,deoxymykoin,dossiciclina,doxcyclineanhydrous,doxiciclina,doxirobe,doxitard,doxivetin,doxycen,doxychel,doxycin,doxycyclin,doxycyclinecalcium,doxycyclinehyclate,doxycyclinum,doxylin,doxysol,doxytec,doxytetracycline,hydramycin,investin,jenacyclin,liviatin,monodox,oracea,periostat,ronaxan,spanor,supracyclin,vibramycin,vibramycine,vibramycinnovum,vibravenos,zenavod"	0.1	"g"	0.1	"g"	"10986-8,18917-5,20379-4,21250-6,224-6,225-3,226-1,227-9,23623-2,25223-9,26902-7,7008-6"
 "ECO"	3198	"Econazole"	"Antifungals/antimycotics"	"D01AC03,G01AF05"	"Antifungals for topical use"	"Imidazole and triazole derivatives"	"econ"	"econazol,econazolum,ecostatin,ecostatincream,palavale,pevaryl,spectazole,spectazolecream"					"25595-0,25637-0,54178-9,55673-8"
 "EFF"		"Efflux"	"Other"	"NA"			"effflux pump"	""					""
 "ENX"	3229	"Enoxacin"	"Quinolones"	"J01MA04"	"Quinolone antibacterials"	"Fluoroquinolones"	"enox"	"almitil,bactidan,bactidron,comprecin,enofloxacine,enoksetin,enoram,enoxacina,enoxacine,enoxacino,enoxacinum,enoxen,enoxin,enoxor,flumark,penetrex"	0.8	"g"			"16816-1,18918-3,228-7,229-5,230-3,231-1,3590-7,41692-5"
@@ -178,7 +178,7 @@
 "EPP"	68916	"Epiroprim"	"Other antibacterials"	"NA"			""	"epiroprima,epiroprime,epiroprimum"					""
 "ERV"	54726192	"Eravacycline"	"Tetracyclines"	"J01AA13"	"Tetracyclines"	"Tetracyclines"	"erav"	"xerava"			0.14	"g"	"100049-6,85423-2,93767-2"
 "ETP"	150610	"Ertapenem"	"Carbapenems"	"J01DH03"	"Other beta-lactam antibacterials"	"Carbapenems"	"erta,etp"	"invanz"			1	"g"	"101486-9,35799-6,35800-2,35801-0,35802-8"
-"ERY"	12560	"Erythromycin"	"Macrolides/lincosamides"	"D10AF02,J01FA01,S01AA17"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"e,em,ery,eryt"	"abboticin,abomacetin,acneryne,acnesol,aknecordeslosung,aknedermerygel,aknemycin,austrias,benzamycin,bristamycin,derimer,deripil,dotycin,dumotrycin,emuvin,emycin,endoeritrin,erecin,erisone,eritomicina,eritrocina,eritromicina,ermycin,eryacne,eryacnen,erycsprinkles,erycen,erycette,erycin,erycinum,eryderm,erydermer,erygel,eryhexal,erymax,erymed,erypar,erysafe,erytab,erythrocin,erythrocinstearate,erythroderm,erythrogran,erythroguent,erythromid,erythromycina,erythromycinbase,erythromycinlactate,erythromycine,erythromycines,erythromycinum,erytop,erytrociclin,ilocaps,ilosone,iloticina,ilotycin,ilotycingluceptate,ilotycints,inderm,indermgel,indermretcin,latotryd,lederpax,mephamycin,mercina,oftamolets,paediathrocin,pantoderm,pantodrin,pantomicina,pcedispertab,pharyngocin,primacine,propiocine,proterytrin,retcin,robimycin,romycin,sansac,skidgele,staticin,stiemicyn,stiemycin,theramycinz,tiloryth,tiprocin,torlamicina,udimaerygel,wyamycins"	2	"g"	1	"g"	"100050-4,11576-6,12298-6,16829-4,16830-2,18919-1,18920-9,20380-2,232-9,233-7,234-5,235-2,236-0,23633-1,237-8,238-6,239-4,25224-7,25275-9,3597-2,7009-4"
+"ERY"	12560	"Erythromycin"	"Macrolides/lincosamides"	"D10AF02,J01FA01,S01AA17"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"e,em,ery,eryt"	"abboticin,abomacetin,acneryne,acnesol,aknecordeslosung,aknedermerygel,aknemycin,austrias,benzamycin,bristamycin,derimer,deripil,dotycin,dumotrycin,emuvin,emycin,endoeritrin,erecin,erisone,eritomicina,eritrocina,eritromicina,ermycin,eryacne,eryacnen,erycen,erycette,erycin,erycinum,erycsprinkles,eryderm,erydermer,erygel,eryhexal,erymax,erymed,erypar,erysafe,erytab,erythrocin,erythrocinstearate,erythroderm,erythrogran,erythroguent,erythromid,erythromycina,erythromycinbase,erythromycine,erythromycines,erythromycinlactate,erythromycinum,erytop,erytrociclin,ilocaps,ilosone,iloticina,ilotycin,ilotycingluceptate,ilotycints,inderm,indermgel,indermretcin,latotryd,lederpax,mephamycin,mercina,oftamolets,paediathrocin,pantoderm,pantodrin,pantomicina,pcedispertab,pharyngocin,primacine,propiocine,proterytrin,retcin,robimycin,romycin,sansac,skidgele,staticin,stiemicyn,stiemycin,theramycinz,tiloryth,tiprocin,torlamicina,udimaerygel,wyamycins"	2	"g"	1	"g"	"100050-4,11576-6,12298-6,16829-4,16830-2,18919-1,18920-9,20380-2,232-9,233-7,234-5,235-2,236-0,23633-1,237-8,238-6,239-4,25224-7,25275-9,3597-2,7009-4"
 "ETH"	14052	"Ethambutol"	"Antimycobacterials"	"J04AK02"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"etha"	"aethambutolum,diambutol,ebutol,etambutol,etambutolo,etapiam,ethambutolum,myambutol,mycobutol,purderal,servambutol,tibutol"	1.2	"g"	1.2	"g"	"100051-2,16841-9,18921-7,20381-0,23625-7,240-2,241-0,242-8,243-6,25187-6,25194-2,25195-9,25230-4,25404-5,3607-9,42645-2,42646-0,55154-9,55674-6,56025-0,7010-2,89491-5"
 "ETI"	456476	"Ethambutol/isoniazid"	"Antimycobacterials"	"J04AM03"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
 "ETI1"	2761171	"Ethionamide"	"Antimycobacterials"	"J04AD03"	"Drugs for treatment of tuberculosis"	"Thiocarbamide derivatives"	"ethi"	"aethionamidum,aetina,aetiva,amidazin,amidazine,ethatyl,ethimide,ethina,ethinamide,ethionamidum,ethioniamide,ethylisothiamide,ethyonomide,etimid,etiocidan,etionamid,etionamida,etionamide,etioniamid,etionid,etionizin,etionizina,etionizine,fatoliamid,iridocin,iridocinbayer,iridozin,isothin,isotiamida,itiocide,nicotion,nisotin,nizotin,rigenicid,sertinon,teberus,thianid,thianide,thioamide,thiodine,thiomid,thioniden,tianid,tiomid,trecator,trecatorsc,trekator,trescatyl,trescazide,tubenamide,tubermin,tuberoid,tuberoson"	0.75	"g"			"16099-4,16845-0,18922-5,20382-8,23617-4,25183-5,25196-7,25198-3,25231-2,41693-3,42647-8,42648-6,7011-0,96110-2"
@@ -197,38 +197,38 @@
 "FLM"	3374	"Flumequine"	"Quinolones"	"J01MB07"	"Quinolone antibacterials"	"Other quinolones"	""	"apurone,fantacin,flumequino,flumequinum,flumigal,flumiquil,flumisol,flumix,imequyl"	1.2	"g"			"55675-3,55676-1,55677-9,55678-7"
 "FLR1"	71260	"Flurithromycin"	"Macrolides/lincosamides"	"J01FA14"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"flurithromicina,flurithromycime,flurithromycine,flurithromycinum,fluritromicina,fluritromycinum,flurizic"	0.75	"g"			""
 "FFL"	214356	"Fosfluconazole"	"Antifungals/antimycotics"	"NA"			""	"phosfluconazole,procif,prodif"					""
-"FOS"	446987	"Fosfomycin"	"Other antibacterials"	"J01XX01,S02AA17"	"Other antibacterials"	"Other antibacterials"	"ff,fm,fo,fof,fos,fosf"	"calciumfosfomycin,fosfocina,fosfomicin,fosfomicina,fosfomycinsodium,fosfomycine,fosfomycinum,fosfonomycin,infectophos,monuril,monurol,phosphonemycin,phosphonomycin,veramina"	3	"g"	8	"g"	"25596-8,25653-7,35809-3,35810-1"
+"FOS"	446987	"Fosfomycin"	"Other antibacterials"	"J01XX01,S02AA17"	"Other antibacterials"	"Other antibacterials"	"ff,fm,fo,fof,fos,fosf"	"calciumfosfomycin,fosfocina,fosfomicin,fosfomicina,fosfomycine,fosfomycinsodium,fosfomycinum,fosfonomycin,infectophos,monuril,monurol,phosphonemycin,phosphonomycin,veramina"	3	"g"	8	"g"	"25596-8,25653-7,35809-3,35810-1"
 "FMD"	572	"Fosmidomycin"	"Other antibacterials"	"NA"			""	"fosmidomycina,fosmidomycine,fosmidomycinum"					""
-"FRM"	8378	"Framycetin"	"Aminoglycosides"	"D09AA01,R01AX08,S01AA07"			"fram"	"actilin,actiline,antibiotique,bycomycin,dekamyciniii,endomixin,enterfram,fradiomycin,fradiomycinb,fradiomycinum,framicetina,framidal,framycetinsulfate,framycetine,framycetinum,framycin,framygen,francetin,fraquinol,jernadex,myacine,myacyne,mycerin,mycifradin,neobrettin,neolate,neomas,neomcin,neomicina,neomin,neomycinb,neomycinbsulfate,neomycinsolution,neomycinsulfate,neomycinsulphate,neomycine,neomycinum,nivemycin,pimavecort,soframycin,soframycine,tuttomycin,vonamycin,vonamycinpowderv"					"18926-6,257-6,258-4,259-2,260-0,55679-5"
+"FRM"	8378	"Framycetin"	"Aminoglycosides"	"D09AA01,R01AX08,S01AA07"			"fram"	"actilin,actiline,antibiotique,bycomycin,dekamyciniii,endomixin,enterfram,fradiomycin,fradiomycinb,fradiomycinum,framicetina,framidal,framycetine,framycetinsulfate,framycetinum,framycin,framygen,francetin,fraquinol,jernadex,myacine,myacyne,mycerin,mycifradin,neobrettin,neolate,neomas,neomcin,neomicina,neomin,neomycinb,neomycinbsulfate,neomycine,neomycinsolution,neomycinsulfate,neomycinsulphate,neomycinum,nivemycin,pimavecort,soframycin,soframycine,tuttomycin,vonamycin,vonamycinpowderv"					"18926-6,257-6,258-4,259-2,260-0,55679-5"
 "FUR"	6870646	"Furazidin"	"Other antibacterials"	"J01XE03"	"Other antibacterials"	"Nitrofuran derivatives"	""	"akritoin,furagin,furaginum,furamag,furazidine"	0.3	"g"			""
 "FRZ"	5323714	"Furazolidone"	"Other antibacterials"	"G01AX06"			""	"bifuron,corizium,coryzium,diafuron,enterotoxon,furall,furaxon,furaxone,furazol,furazolidine,furazolidon,furazolidona,furazolidonum,furazolum,furazon,furidon,furovag,furoxaerosolpowder,furoxal,furoxane,furoxon,furoxone,furoxoneliquid,furoxoneswinemix,furozolidine,giardil,giarlam,medaron,neftin,nicolen,nifulidone,nifuran,nifurazolidone,nifurazolidonum,nitrofurazolidone,nitrofurazolidonum,nitrofuroxon,optazol,ortazol,puradin,roptazol,sclaventerol,tikofuran,topazone,trichofuron,tricofuron,tricoron,trifurox,viofuragyn"					"69574-2,87794-4"
 "FUS"	3000226	"Fusidic acid"	"Other antibacterials"	"D06AX01,D09AA02,J01XC01,S01AA13"	"Other antibacterials"	"Steroid antibacterials"	"fa,fusi"	"acidefusidique,acidofusidico,acidumfusidicum,flucidin,fucidate,fucidatesodium,fucidicacid,fucidin,fucidinacid,fucithalmic,fusidate,fusidateacid,fusidicacid,fusidine,fusidinicacid,ramycin,taksta"	1.5	"g"	1.5	"g"	""
 "GAM"	59364992	"Gamithromycin"	"Macrolides/lincosamides"	"QJ01FA95"			""	""					"100054-6,88376-9,88378-5"
 "GRN"	124093	"Garenoxacin"	"Quinolones"	"J01MA19"			""	"ganefloxacin,garenfloxacin"	0.4	"g"			"35811-9,35812-7,35813-5"
-"GAT"	5379	"Gatifloxacin"	"Quinolones"	"J01MA16,S01AE06"	"Quinolone antibacterials"	"Fluoroquinolones"	"gati"	"gatiflo,gatifloxacinhydrate,gatifloxacine,gatifloxcin,gatilox,gatiquin,gatispan,tequin,tequinandzymar,zymaxid"	0.4	"g"	0.4	"g"	"31036-7,31038-3,31040-9,31042-5,41494-6"
+"GAT"	5379	"Gatifloxacin"	"Quinolones"	"J01MA16,S01AE06"	"Quinolone antibacterials"	"Fluoroquinolones"	"gati"	"gatiflo,gatifloxacine,gatifloxacinhydrate,gatifloxcin,gatilox,gatiquin,gatispan,tequin,tequinandzymar,zymaxid"	0.4	"g"	0.4	"g"	"31036-7,31038-3,31040-9,31042-5,41494-6"
 "GEM"	9571107	"Gemifloxacin"	"Quinolones"	"J01MA15"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"factiv,factive,gemifioxacin,gemifloxacine,gemifloxacino,gemifloxacinum"	0.32	"g"	0.2	"g"	"35814-3,35815-0,35816-8,41697-4"
 "GEN"	3467	"Gentamicin"	"Aminoglycosides"	"D06AX07,J01GB03,S01AA11,S02AA14,S03AA06"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"cn,gen,gent,gm"	"apogen,centicin,cidomycin,garamycin,garasol,genopticliquifilm,genopticsop,gentacycol,gentafair,gentak,gentamar,gentamcinsulfate,gentamicina,gentamicine,gentamicins,gentamicinum,gentamycin,gentamycins,gentamycinum,gentavet,gentocin,jenamicin,lyramycin,oksitselanim,refobacin,refobacintm,septigen,uromycine"			0.24	"g"	"101494-3,13561-6,13562-4,15106-8,18928-2,18929-0,22746-2,22747-0,266-7,267-5,268-3,269-1,31091-2,31092-0,31093-8,35668-3,35817-6,3663-2,3664-0,3665-7,39082-3,47109-4,50630-3,59379-8,7016-9,7017-7,7018-5,80971-5,88111-0,89481-6"
 "GEH"		"Gentamicin-high"	"Aminoglycosides"	"NA"			"gehi,gehl,genta high,gentamicin high"	""					"18929-0,35817-6,7017-7,7018-5"
 "GEP"	25101874	"Gepotidacin"	"Other antibacterials"	"NA"			""	""					""
 "GRX"	72474	"Grepafloxacin"	"Quinolones"	"J01MA11"	"Quinolone antibacterials"	"Fluoroquinolones"	"grep"	""	0.4	"g"			"21316-5,23638-0,23639-8,35818-4"
-"GRI"	441140	"Griseofulvin"	"Antifungals/antimycotics"	"D01AA08,D01BA01"			""	"amudane,curlingfactor,delmofulvina,fulcin,fulcine,fulvicangrisactin,fulvicin,fulvicinbolus,fulvidex,fulvina,fulvinil,fulvistatin,fungivin,greosin,gresfeed,gricin,grifulin,grifulvin,grifulvinv,grisactin,grisactinultra,grisactinv,griscofulvin,griseostatin,grisefuline,griseo,griseoflulvin,griseofulvinforte,griseofulvina,griseofulvine,griseofulvinum,griseomix,grisetin,grisofulvin,grisovin,grisovinfp,grizeofulvin,grysio,guservin,lamoryl,likuden,likunden,murfulvin,poncyl,spirofulvin,sporostatinxan,xuanjing"	0.5	"g"			"12402-4,54200-1,54201-9,54202-7"
+"GRI"	441140	"Griseofulvin"	"Antifungals/antimycotics"	"D01AA08,D01BA01"			""	"amudane,curlingfactor,delmofulvina,fulcin,fulcine,fulvicangrisactin,fulvicin,fulvicinbolus,fulvidex,fulvina,fulvinil,fulvistatin,fungivin,greosin,gresfeed,gricin,grifulin,grifulvin,grifulvinv,grisactin,grisactinultra,grisactinv,griscofulvin,grisefuline,griseo,griseoflulvin,griseofulvina,griseofulvine,griseofulvinforte,griseofulvinum,griseomix,griseostatin,grisetin,grisofulvin,grisovin,grisovinfp,grizeofulvin,grysio,guservin,lamoryl,likuden,likunden,murfulvin,poncyl,spirofulvin,sporostatinxan,xuanjing"	0.5	"g"			"12402-4,54200-1,54201-9,54202-7"
 "HAB"	175989	"Habekacin"	"Aminoglycosides"	"NA"			""	"arbekacinsulfate,arbekacinsulphate,habekacinsulfate,habekacinxsulfate"					""
 "HCH"	11979956	"Hachimycin"	"Antifungals/antimycotics"	"D01AA03,G01AA06,J02AA02"	"Antimycotics for systemic use"	"Antibiotics"	""	"cabimicina,hachimicina,hachimycine,hachimycinum,trichomycinum,trichonat"					""
 "HET"	443387	"Hetacillin"	"Beta-lactams/penicillins"	"J01CA18"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"etacillina,hetacilina,hetacillinacid,hetacilline,hetacillinum,phenazacillin,versapen"	2	"g"			"18931-6,274-1,275-8,276-6,277-4"
 "HYG"	56928061	"Hygromycin"	"Aminoglycosides"	"NA"			""	"antihelmycin,hydromycinb,hygrovetine"					""
 "IBX"		"Ibrexafungerp"	"Antifungals"	"J02AX07"			""	""					""
 "ICL"	213043	"Iclaprim"	"Other antibacterials"	"J01EA03"			""	"mersarex"					"73597-7,73619-9,73642-1"
-"IPM"	104838	"Imipenem"	"Carbapenems"	"J01DH51"	"Other beta-lactam antibacterials"	"Carbapenems"	"imci,imi,imip,imp"	"imipemide,imipenemanhydrous,imipenemhydrate,imipenemcilastatin,imipenemum,imipenen,primaxin,recarbrio,tienamycin"			2	"g"	"101487-7,17010-0,18932-4,18933-2,23613-3,25221-3,25257-7,27331-8,278-2,279-0,280-8,281-6,282-4,283-2,284-0,285-7,35819-2,3688-9,54170-6,54171-4,54172-2,7019-3,85424-0,93232-7,96372-8"
+"IPM"	104838	"Imipenem"	"Carbapenems"	"J01DH51"	"Other beta-lactam antibacterials"	"Carbapenems"	"imci,imi,imip,imp"	"imipemide,imipenemanhydrous,imipenemcilastatin,imipenemhydrate,imipenemum,imipenen,primaxin,recarbrio,tienamycin"			2	"g"	"101487-7,17010-0,18932-4,18933-2,23613-3,25221-3,25257-7,27331-8,278-2,279-0,280-8,281-6,282-4,283-2,284-0,285-7,35819-2,3688-9,54170-6,54171-4,54172-2,7019-3,85424-0,93232-7,96372-8"
 "IPE"		"Imipenem/EDTA"	"Carbapenems"	"NA"			""	""					"35819-2,54170-6,54171-4,54172-2"
 "IMR"		"Imipenem/relebactam"	"Carbapenems"	"NA,J01DH56"			""	""			2	"g"	"85424-0,93232-7,96372-8"
 "ISV"	6918485	"Isavuconazole"	"Antifungals/antimycotics"	"J02AC05"			"isav"	""	0.2	"g"	0.2	"g"	"85381-2,88887-5"
 "ISE"	3037209	"Isepamicin"	"Aminoglycosides"	"J01GB11"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	""	"isepacin,isepalline,isepamicina,isepamicine,isepamicinsulphate,isepamicinum"			0.4	"g"	"32381-6,35820-0,35821-8,55680-3"
 "ISO"	3760	"Isoconazole"	"Antifungals/antimycotics"	"D01AC05,G01AF07"	"Antimycotics for topic use"	"Triazole derivatives"	""	"isoconazol,isoconazolum,travogen"					"55681-1,55682-9,55683-7,55684-5"
-"INH"	3767	"Isoniazid"	"Antimycobacterials"	"J04AC01"	"Drugs for treatment of tuberculosis"	"Hydrazides"	"inh"	"abdizide,andrazide,anidrasona,antimicina,antituberkulosum,armacide,armazid,armazide,atcotibine,aztisoniazid,azuren,bacillin,cemidon,chemiazid,chemidon,continazine,cortinazine,cotinazin,cotinizin,defonin,dianicotyl,dibutin,diforin,dinacrin,ditubin,ebidene,eralon,ertuban,eutizon,evalon,fetefu,fimalene,hidrasonil,hidranizil,hidrulta,hidrun,hycozid,hydrazid,hydrazide,hyozid,iai,idrazil,inizid,ipcazide,iscotin,isidrina,ismazide,isobicina,isocid,isocidene,isocotin,isohydrazide,isokin,isolyn,isonerit,isonex,isoniacid,isoniazidsa,isoniazida,isoniazide,isoniazidum,isonicazide,isonicid,isonico,isonicotan,isonicotil,isonicotinhydrazid,isonicotinohydrazide,isonide,isonidrin,isonikazid,isonilex,isonin,isonindon,isonirit,isoniton,isonizida,isonizide,isotamine,isotebe,isotebezid,isotinyl,isozid,isozide,isozyd,laniazid,laniozid,lanizid,mayambutol,mybasan,neoteben,neoxin,neumandin,niadrin,nicazide,nicetal,nicizina,niconyl,nicotibina,nicotibine,nicotisan,nicozide,nidaton,nidrazid,nikozid,niplen,nitadon,niteban,nydrazid,nyscozid,pelazid,percin,phthisen,pycazide,pyreazid,pyricidin,pyridicin,pyrizidin,raumanon,razide,retozide,rifater,rimicid,rimifon,rimiphone,rimitsid,robiselin,robisellin,roxifen,sanohidrazina,sauterazid,sauterzid,stanozide,tebecid,tebenic,tebexin,tebilon,teebaconin,tekazin,tibazide,tibemid,tibiazide,tibinide,tibison,tibivis,tibizide,tibusan,tisiodrazida,tizide,tubazid,tubazide,tubeco,tubecotubercid,tuberian,tubicon,tubilysin,tubizid,tubomel,unicocyde,unicozyde,vazadrine,vederon,zidafimia,zinadon,zonazide"	0.3	"g"	0.3	"g"	"18934-0,20383-6,23947-5,25217-1,25218-9,25219-7,25451-6,26756-7,286-5,287-3,288-1,289-9,29315-9,3697-0,40371-7,42649-4,42650-2,42651-0,45215-1,48171-3,48172-1,55685-2,7020-1,89488-1"
+"INH"	3767	"Isoniazid"	"Antimycobacterials"	"J04AC01"	"Drugs for treatment of tuberculosis"	"Hydrazides"	"inh"	"abdizide,andrazide,anidrasona,antimicina,antituberkulosum,armacide,armazid,armazide,atcotibine,aztisoniazid,azuren,bacillin,cemidon,chemiazid,chemidon,continazine,cortinazine,cotinazin,cotinizin,defonin,dianicotyl,dibutin,diforin,dinacrin,ditubin,ebidene,eralon,ertuban,eutizon,evalon,fetefu,fimalene,hidranizil,hidrasonil,hidrulta,hidrun,hycozid,hydrazid,hydrazide,hyozid,iai,idrazil,inizid,ipcazide,iscotin,isidrina,ismazide,isobicina,isocid,isocidene,isocotin,isohydrazide,isokin,isolyn,isonerit,isonex,isoniacid,isoniazida,isoniazide,isoniazidsa,isoniazidum,isonicazide,isonicid,isonico,isonicotan,isonicotil,isonicotinhydrazid,isonicotinohydrazide,isonide,isonidrin,isonikazid,isonilex,isonin,isonindon,isonirit,isoniton,isonizida,isonizide,isotamine,isotebe,isotebezid,isotinyl,isozid,isozide,isozyd,laniazid,laniozid,lanizid,mayambutol,mybasan,neoteben,neoxin,neumandin,niadrin,nicazide,nicetal,nicizina,niconyl,nicotibina,nicotibine,nicotisan,nicozide,nidaton,nidrazid,nikozid,niplen,nitadon,niteban,nydrazid,nyscozid,pelazid,percin,phthisen,pycazide,pyreazid,pyricidin,pyridicin,pyrizidin,raumanon,razide,retozide,rifater,rimicid,rimifon,rimiphone,rimitsid,robiselin,robisellin,roxifen,sanohidrazina,sauterazid,sauterzid,stanozide,tebecid,tebenic,tebexin,tebilon,teebaconin,tekazin,tibazide,tibemid,tibiazide,tibinide,tibison,tibivis,tibizide,tibusan,tisiodrazida,tizide,tubazid,tubazide,tubeco,tubecotubercid,tuberian,tubicon,tubilysin,tubizid,tubomel,unicocyde,unicozyde,vazadrine,vederon,zidafimia,zinadon,zonazide"	0.3	"g"	0.3	"g"	"18934-0,20383-6,23947-5,25217-1,25218-9,25219-7,25451-6,26756-7,286-5,287-3,288-1,289-9,29315-9,3697-0,40371-7,42649-4,42650-2,42651-0,45215-1,48171-3,48172-1,55685-2,7020-1,89488-1"
 "IST"		"Isoniazid/sulfamethoxazole/trimethoprim/pyridoxine"	"Antimycobacterials"	"J04AM08"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
 "ITR"	3793	"Itraconazole"	"Antifungals/antimycotics"	"J02AC02"	"Antimycotics for systemic use"	"Triazole derivatives"	"itra"	"intraconazole,itraconazol,itraconazolo,itraconazolum,itraconzaole,itrazole,itrizole,oriconazole,sporanox"	0.2	"g"	0.2	"g"	"10989-2,12392-7,25258-5,25452-4,27081-9,32184-4,32185-1,32603-3,54179-7,7021-9,80531-7"
 "JOS"	5282165	"Josamycin"	"Macrolides/lincosamides"	"J01FA07"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"jomybel,josacine,josamicina,josamycine,josamycinum"	2	"g"			"25597-6,25702-2,41698-2,41699-0"
-"KAN"	6032	"Kanamycin"	"Aminoglycosides"	"A07AA08,J01GB04,S01AA24"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"hlk,k,kan,kana,km"	"kanamicina,kanamycina,kanamycinbase,kanamycinsulfate,kanamycine,kanamycins,kanamycinum,kantrex,kenamycina,klebcil,liposomalkanamycin"	3	"g"	1	"g"	"18935-7,18936-5,23609-1,23889-9,25182-7,25213-0,25214-8,290-7,291-5,292-3,293-1,3698-8,3699-6,3700-2,42652-8,47395-9,49080-5,7022-7,7023-5,7024-3,88002-1,88705-9,89482-4"
+"KAN"	6032	"Kanamycin"	"Aminoglycosides"	"A07AA08,J01GB04,S01AA24"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"hlk,k,kan,kana,km"	"kanamicina,kanamycina,kanamycinbase,kanamycine,kanamycins,kanamycinsulfate,kanamycinum,kantrex,kenamycina,klebcil,liposomalkanamycin"	3	"g"	1	"g"	"18935-7,18936-5,23609-1,23889-9,25182-7,25213-0,25214-8,290-7,291-5,292-3,293-1,3698-8,3699-6,3700-2,42652-8,47395-9,49080-5,7022-7,7023-5,7024-3,88002-1,88705-9,89482-4"
 "KAH"		"Kanamycin-high"	"Aminoglycosides"	"NA"			"k_h,kahl"	""					"18936-5,7023-5,7024-3"
 "KAC"		"Kanamycin/cephalexin"	"Aminoglycosides"	"NA"			""	""					""
 "KET"	456201	"Ketoconazole"	"Antifungals/antimycotics"	"D01AC08,G01AF11,H02CA03,J02AB02"	"Antimycotics for systemic use"	"Imidazole derivatives"	"keto,ktc"	"extina,fungarest,fungoral,ketocanazole,ketoconazol,ketoconazolum,ketoderm,nizoral,xolegel"	0.6	"g"			"10990-0,12393-5,18937-3,25259-3,294-9,295-6,296-4,297-2,60091-6,60092-4,7025-0"
@@ -237,8 +237,8 @@
 "LSC"	71528768	"Lascufloxacin"	"Quinolones"	"J01MA25"	"Quinolone antibacterials"	"Fluoroquinolones"	""	""	75	"mg"			""
 "LTM"	47499	"Latamoxef"	"Cephalosporins (3rd gen.)"	"J01DD06"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"mox,moxa,moxalactam"	"disodiummoxalactam,festamoxin,lamoxactam,latamoxefum,moxalactamsupplement,shiomarin"			4	"g"	""
 "LMU"	25185057	"Lefamulin"	"Other antibacterials"	"J01XX12"			""	"xenleta"					"85425-7,99281-8"
-"LEN"	65646	"Lenampicillin"	"Beta-lactams/penicillins"	"NA"			""	"lenampicilina,lenampicillinhcl,lenampicilline,lenampicillinum"					""
+"LEN"	65646	"Lenampicillin"	"Beta-lactams/penicillins"	"NA"			""	"lenampicilina,lenampicilline,lenampicillinhcl,lenampicillinum"					""
-"LVX"	149096	"Levofloxacin"	"Quinolones"	"J01MA12,S01AE05"	"Quinolone antibacterials"	"Fluoroquinolones"	"le,lev,levo,lvx"	"aeroquin,anhydrousofloxacin,cravit,cravithydrate,cravitiv,cravitophthalmic,elequine,floxacin,floxel,fluoroquinolone,iquixhydrate,leroxacin,lesacin,levaquin,levaquinhydrate,levofiexacin,levofloxacinhydrate,levofloxacine,levofloxacino,levofloxacinum,levokacin,levoxacin,mosardal,nofaxin,ofloxcacin,oftaquix,quinsair,quixin,reskuin,tavanic,unibiotic,venaxan,volequin"	0.5	"g"	0.5	"g"	"101501-5,20396-8,20629-2,21367-8,21368-6,30532-6,30533-4,48173-9,53716-7,7026-8,76040-5,76041-3,76042-1"
+"LVX"	149096	"Levofloxacin"	"Quinolones"	"J01MA12,S01AE05"	"Quinolone antibacterials"	"Fluoroquinolones"	"le,lev,levo,lvx"	"aeroquin,anhydrousofloxacin,cravit,cravithydrate,cravitiv,cravitophthalmic,elequine,floxacin,floxel,fluoroquinolone,iquixhydrate,leroxacin,lesacin,levaquin,levaquinhydrate,levofiexacin,levofloxacine,levofloxacinhydrate,levofloxacino,levofloxacinum,levokacin,levoxacin,mosardal,nofaxin,ofloxcacin,oftaquix,quinsair,quixin,reskuin,tavanic,unibiotic,venaxan,volequin"	0.5	"g"	0.5	"g"	"101501-5,20396-8,20629-2,21367-8,21368-6,30532-6,30533-4,48173-9,53716-7,7026-8,76040-5,76041-3,76042-1"
 "LEO"		"Levofloxacin/ornidazole"	"Other antibacterials"	"J01RA05"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "LND"	9850038	"Levonadifloxacin"	"Quinolones"	"J01MA24"			""	""					""
 "LSP"		"Linco-spectin"	"Other antibacterials"	"NA"			"lincomycin/spectinomycin"	""					""
@@ -258,13 +258,13 @@
 "MEV"		"Meropenem/vaborbactam"	"Carbapenems"	"J01DH52"	"Other beta-lactam antibacterials"	"Carbapenems"	""	"carbavance,vabomere"			3	"g"	"101222-8,101489-3,85427-3,88892-5,90980-4"
 "MES"	176886	"Mesulfamide"	"Other antibacterials"	"NA"			""	"mesulfamido,mesulfamidum"					""
 "MTC"	54675785	"Metacycline"	"Tetracyclines"	"J01AA05"	"Tetracyclines"	"Tetracyclines"	""	"bialatan,metaciclina,metacyclinum,methacycline,methacyclinebase,methacyclinum,methylenecycline,physiomycine,rondomycin"	0.6	"g"			""
-"MTM"	6713928	"Metampicillin"	"Beta-lactams/penicillins"	"J01CA14"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"blomopen,bonopen,celinmicina,elatocilline,fedacilinakapseln,filorex,italcinakapseln,magnipen,metabacterampullen,metambac,metampicilina,metampicillinsodium,metampicillina,metampicilline,metampicillinum,methampicillin,metiskiaampullen,micinovo,micinovoampullen,pangocilin,probiotic,rastomycink,relyothenate,ruticina,rutizina,rutizinaampullen,sedomycin,suvipen,suvipenampullen,tampilenampullen,teonicontrofen,viderpen,viderpin,vioplex"	1.5	"g"	1.5	"g"	""
+"MTM"	6713928	"Metampicillin"	"Beta-lactams/penicillins"	"J01CA14"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"blomopen,bonopen,celinmicina,elatocilline,fedacilinakapseln,filorex,italcinakapseln,magnipen,metabacterampullen,metambac,metampicilina,metampicillina,metampicilline,metampicillinsodium,metampicillinum,methampicillin,metiskiaampullen,micinovo,micinovoampullen,pangocilin,probiotic,rastomycink,relyothenate,ruticina,rutizina,rutizinaampullen,sedomycin,suvipen,suvipenampullen,tampilenampullen,teonicontrofen,viderpen,viderpin,vioplex"	1.5	"g"	1.5	"g"	""
-"MTH"	4101	"Methenamine"	"Other antibacterials"	"J01XX05"	"Other antibacterials"	"Other antibacterials"	""	"acetohmt,aminoform,aminoformaldehyde,ammoform,ammonioformaldehyde,antihydral,cystamin,cystex,cystogen,duirexol,ekagomh,esametilentetramina,formamine,formin,hmt,heksak,heraxuts,heterin,hexab,hexaform,hexaloids,hexamethylamine,hexamethylenamine,hexamethyleneamine,hexamethylentetramin,hexamine,hexaminesilver,hexaminesuperfine,hexaminum,hexasan,hexilmethylenamine,mandelamine,metenamina,metenamine,methamin,methenamin,methenaminesilver,methenaminum,metramine,naphthamine,noccelerh,preparationaf,resotropin,sancelerh,sancelerht,silvermethenamine,uramin,uratrine,urisol,uritone,urodeine,urotropin,urotropine,vesaloin,vesalvine,xametrin"	3	"g"			""
+"MTH"	4101	"Methenamine"	"Other antibacterials"	"J01XX05"	"Other antibacterials"	"Other antibacterials"	""	"acetohmt,aminoform,aminoformaldehyde,ammoform,ammonioformaldehyde,antihydral,cystamin,cystex,cystogen,duirexol,ekagomh,esametilentetramina,formamine,formin,heksak,heraxuts,heterin,hexab,hexaform,hexaloids,hexamethylamine,hexamethylenamine,hexamethyleneamine,hexamethylentetramin,hexamine,hexaminesilver,hexaminesuperfine,hexaminum,hexasan,hexilmethylenamine,hmt,mandelamine,metenamina,metenamine,methamin,methenamin,methenaminesilver,methenaminum,metramine,naphthamine,noccelerh,preparationaf,resotropin,sancelerh,sancelerht,silvermethenamine,uramin,uratrine,urisol,uritone,urodeine,urotropin,urotropine,vesaloin,vesalvine,xametrin"	3	"g"			""
 "MET"	6087	"Meticillin"	"Beta-lactams/penicillins"	"J01CF03"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"meti"	"dimocillin,metacillin,methcilline,methicillin,methicillinum,methycillin,meticilina,meticillina,meticilline,meticillinum,staphcillin"			4	"g"	""
 "MTP"	68590	"Metioprim"	"Other antibacterials"	"NA"			""	"methioprim,metioprima,metioprime,metioprimum"					""
 "MXT"	3047729	"Metioxate"	"Quinolones"	"NA"			""	"metioxato,metioxatum"					""
-"MTR"	4173	"Metronidazole"	"Other antibacterials"	"A01AB17,D06BX01,G01AF01,J01XD01,P01AB01"	"Other antibacterials"	"Imidazole derivatives"	"metr,mnz"	"acromona,anagiardil,arilin,atrivyl,danizol,deflamon,donnan,efloran,elyzol,entizol,flagemona,flagesol,flagil,flagyl,flagyler,flagyliv,flagylivrtu,flazol,flegyl,florazole,fossyol,giatricol,gineflavir,helidac,mepagyl,meronidal,methronidazole,metric,metrocream,metrogel,metroiv,metrodzhil,metrogyl,metrolag,metrolotion,metrolyl,metromidol,metronidaz,metronidazol,metronidazoleusp,metronidazolo,metronidazolum,metrotop,metrozine,metryl,mexibol,mexibolsilanes,monagyl,monasin,nidagel,nidagyl,noritate,novonidazol,nuvessa,orvagil,polibiotic,protostat,rathimed,rosased,sanatrichom,satric,takimetol,trichazol,trichex,trichocordes,trichobrol,trichocide,trichomol,trichopal,trichopol,tricocet,tricom,tricowasb,trikacide,trikamon,trikhopol,trikojol,trikozol,trimeks,trivazol,vagilen,vagimid,vandazole,vertisal,wagitran,zadstat,zidoval"	2	"g"	1.5	"g"	"10991-8,18946-4,326-9,327-7,328-5,329-3,7031-8"
+"MTR"	4173	"Metronidazole"	"Other antibacterials"	"A01AB17,D06BX01,G01AF01,J01XD01,P01AB01"	"Other antibacterials"	"Imidazole derivatives"	"metr,mnz"	"acromona,anagiardil,arilin,atrivyl,danizol,deflamon,donnan,efloran,elyzol,entizol,flagemona,flagesol,flagil,flagyl,flagyler,flagyliv,flagylivrtu,flazol,flegyl,florazole,fossyol,giatricol,gineflavir,helidac,mepagyl,meronidal,methronidazole,metric,metrocream,metrodzhil,metrogel,metrogyl,metroiv,metrolag,metrolotion,metrolyl,metromidol,metronidaz,metronidazol,metronidazoleusp,metronidazolo,metronidazolum,metrotop,metrozine,metryl,mexibol,mexibolsilanes,monagyl,monasin,nidagel,nidagyl,noritate,novonidazol,nuvessa,orvagil,polibiotic,protostat,rathimed,rosased,sanatrichom,satric,takimetol,trichazol,trichex,trichobrol,trichocide,trichocordes,trichomol,trichopal,trichopol,tricocet,tricom,tricowasb,trikacide,trikamon,trikhopol,trikojol,trikozol,trimeks,trivazol,vagilen,vagimid,vandazole,vertisal,wagitran,zadstat,zidoval"	2	"g"	1.5	"g"	"10991-8,18946-4,326-9,327-7,328-5,329-3,7031-8"
-"MEZ"	656511	"Mezlocillin"	"Beta-lactams/penicillins"	"J01CA10"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"mez,mezl,mz"	"mezlin,mezlocilina,mezlocillinacid,mezlocillinsodium,mezlocilline,mezlocillinum,multocillin"			6	"g"	"18947-2,330-1,331-9,332-7,333-5,3820-8,41702-2,54194-6,54195-3,54196-1"
+"MEZ"	656511	"Mezlocillin"	"Beta-lactams/penicillins"	"J01CA10"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"mez,mezl,mz"	"mezlin,mezlocilina,mezlocillinacid,mezlocilline,mezlocillinsodium,mezlocillinum,multocillin"			6	"g"	"18947-2,330-1,331-9,332-7,333-5,3820-8,41702-2,54194-6,54195-3,54196-1"
 "MSU"		"Mezlocillin/sulbactam"	"Beta-lactams/penicillins"	"NA"			""	""					"54194-6,54195-3,54196-1"
 "MIF"	477468	"Micafungin"	"Antifungals/antimycotics"	"J02AX05"	"Antimycotics for systemic use"	"Other antimycotics for systemic use"	"mica"	"mycamine"			0.1	"g"	"53812-4,58418-5,65340-2,85048-7"
 "MCZ"	4189	"Miconazole"	"Antifungals/antimycotics"	"A01AB09,A07AC01,D01AC02,G01AF04,J02AB01,S02AA13"	"Antimycotics for systemic use"	"Imidazole derivatives"	"mico"	"aflorix,albistat,andergin,brentan,conofite,dactarin,daktarin,daktariniv,florid,lotriminaf,micantin,miconasilnitrate,miconazol,miconazolebase,miconazolo,miconazolum,micozole,minostate,monista,monistat,monistativ,oravig,vusion,zimybase,zimycan"	0.2	"g"	1	"g"	"17278-3,25607-3,25722-0,54180-5,55686-0"
@@ -279,18 +279,18 @@
 "MUP"	446596	"Mupirocin"	"Other antibacterials"	"D06AX09,R01AX06"			"mup,mupi"	"bactoderm,bactroban,bactrobannasal,bactrobanointment,centany,mupirocina,mupirocine,mupirocinum,plasimine,pseudomonicacid,pseudomonicacida,turixin"					"20389-3,35822-6,35823-4,60542-8,60543-6,7033-4"
 "NAC"	73386748	"Nacubactam"	"Beta-lactams/penicillins"	"NA"			""	""					""
 "NAD"	4410	"Nadifloxacin"	"Quinolones"	"D10AF05"			""	"acuatim,nadifloxacine,nadifloxacino,nadifloxacinum,nadixa,nadoxin"					""
-"NAF"	8982	"Nafcillin"	"Beta-lactams/penicillins"	"J01CF06"			""	"nafcilina,nafcillinsodium,nafcilline,nafcillinum,nallpen,naphcillin,unipen"			3	"g"	"10993-4,18951-4,25232-0,346-7,347-5,348-3,349-1,41704-8"
+"NAF"	8982	"Nafcillin"	"Beta-lactams/penicillins"	"J01CF06"			""	"nafcilina,nafcilline,nafcillinsodium,nafcillinum,nallpen,naphcillin,unipen"			3	"g"	"10993-4,18951-4,25232-0,346-7,347-5,348-3,349-1,41704-8"
 "ZWK"	117587595	"Nafithromycin"	"Macrolides/lincosamides"	"NA"			""	""					""
 "NAL"	4421	"Nalidixic acid"	"Quinolones"	"J01MB02"	"Quinolone antibacterials"	"Other quinolones"	"na,nal,nali"	"acidenalidixico,acidenalidixique,acidonalidissico,acidonalidixico,acidumnalidixicum,betaxina,dixiben,dixinal,eucisten,eucistin,innoxalomn,innoxalon,jicsron,kusnarin,naldixicacid,nalidicacid,nalidicron,nalidixan,nalidixane,nalidixate,nalidixatesodium,nalidixic,nalidixicacid,nalidixin,nalidixinicacid,nalidixinsaure,nalitucsan,nalurin,narigix,naxuril,neggram,negram,nevigramon,nicelate,nogram,poleon,sicmylon,specifen,specifin,unaserus,uralgin,uriben,uriclar,urisal,urodixin,uroman,uroneg,uronidix,uropan,wintomylon,wintron"	4	"g"			""
 "NAR"	65452	"Narasin"	"Other antibacterials"	"QP51BB04"			""	"monteban,narasina,narasine,narasino,narasinum,narasul"					"87570-8"
 "NEM"	11993740	"Nemonoxacin"	"Quinolones"	"J01MB08"	"Quinolone antibacterials"	"Other quinolones"	""	""					""
-"NEO"	8378	"Neomycin"	"Aminoglycosides"	"A01AB08,A07AA01,B05CA09,D06AX04,J01GB05,R02AB01,S01AA03,S02AA07,S03AA01"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"neom"	"actilin,actiline,antibiotique,bycomycin,dekamyciniii,endomixin,enterfram,fradiomycin,fradiomycinb,fradiomycinum,framicetina,framidal,framycetinsulfate,framycetine,framycetinum,framycin,framygen,francetin,fraquinol,jernadex,myacine,myacyne,mycerin,mycifradin,neobrettin,neolate,neomas,neomcin,neomicina,neomin,neomycinb,neomycinbsulfate,neomycinsolution,neomycinsulfate,neomycinsulphate,neomycine,neomycinum,nivemycin,pimavecort,soframycin,soframycine,tuttomycin,vonamycin,vonamycinpowderv"	5	"g"	1	"g"	"10995-9,18953-0,25262-7,354-1,355-8,356-6,357-4,41705-5"
+"NEO"	8378	"Neomycin"	"Aminoglycosides"	"A01AB08,A07AA01,B05CA09,D06AX04,J01GB05,R02AB01,S01AA03,S02AA07,S03AA01"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"neom"	"actilin,actiline,antibiotique,bycomycin,dekamyciniii,endomixin,enterfram,fradiomycin,fradiomycinb,fradiomycinum,framicetina,framidal,framycetine,framycetinsulfate,framycetinum,framycin,framygen,francetin,fraquinol,jernadex,myacine,myacyne,mycerin,mycifradin,neobrettin,neolate,neomas,neomcin,neomicina,neomin,neomycinb,neomycinbsulfate,neomycine,neomycinsolution,neomycinsulfate,neomycinsulphate,neomycinum,nivemycin,pimavecort,soframycin,soframycine,tuttomycin,vonamycin,vonamycinpowderv"	5	"g"	1	"g"	"10995-9,18953-0,25262-7,354-1,355-8,356-6,357-4,41705-5"
-"NET"	441306	"Netilmicin"	"Aminoglycosides"	"J01GB07,S01AA23"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"neti"	"netillin,netilmicinsulfate,netilmicina,netilmicine,netilmicinum,netilyn,netira,nettacin,vectacin"	0.35	"g"	0.35	"g"	"18954-8,25263-5,358-2,359-0,360-8,361-6,3848-9,3849-7,3850-5,47385-0,59565-2,59566-0,59567-8,7035-9"
+"NET"	441306	"Netilmicin"	"Aminoglycosides"	"J01GB07,S01AA23"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"neti"	"netillin,netilmicina,netilmicine,netilmicinsulfate,netilmicinum,netilyn,netira,nettacin,vectacin"	0.35	"g"	0.35	"g"	"18954-8,25263-5,358-2,359-0,360-8,361-6,3848-9,3849-7,3850-5,47385-0,59565-2,59566-0,59567-8,7035-9"
 "NIC"	9507	"Nicarbazin"	"Other antibacterials"	"NA"			""	"nicarb,nicarbasin,nicarbazine,nicoxin,nicrazin,nicrazine,nirazin"					""
 "NIF"	71946	"Nifuroquine"	"Quinolones"	"NA"			""	"abimasten,nifuroquina,nifuroquinum,quinaldofur"					""
 "NFR"	9571062	"Nifurtoinol"	"Other antibacterials"	"J01XE02"	"Other antibacterials"	"Nitrofuran derivatives"	""	"levantin,nifurtoinolo,nifurtoinolum,urfadin,urfadine,urfadyn"	0.16	"g"			""
 "NTZ"	41684	"Nitazoxanide"	"Other antibacterials"	"P01AX11"			""	"adrovet,alinia,aztnitazoxanide,colufase,cryptaz,dexidex,heliton,kidonax,nitaxozanid,nitaxozanide,nitazox,nitazoxamide,nitazoxanid,nitazoxanida,nitazoxanidum,nitrazoxanide,omniparax,pacovanton,paramix,taenitaz"	1	"g"			"73595-1,73617-3,73640-5"
-"NIT"	6604200	"Nitrofurantoin"	"Other antibacterials"	"J01XE01"	"Other antibacterials"	"Nitrofuran derivatives"	"f,f/m,fd,ft,ni,nit,nitr"	"alfuran,benkfuran,berkfuran,berkfurin,ceduran,chemiofuran,cistofuran,cyantin,cystit,dantafur,fuamed,furabid,furachel,furadantin,furadantinretard,furadantinamc,furadantine,furadantinemc,furadantoin,furadoin,furadoine,furadonin,furadonine,furadoninum,furadontin,furadoxyl,furalan,furaloid,furantoin,furantoina,furatoin,furedan,furina,furobactina,furodantin,furophent,gerofuran,ioussaixoo,ituran,ivadantin,macpac,macrobid,macrodantin,macrodantina,macrofuran,macrofurin,nierofu,nifurantin,nifuretten,nitoin,nitrex,nitrofuradantin,nitrofurantion,nitrofurantoinmacro,nitrofurantoina,nitrofurantoine,nitrofurantoinum,novofuran,orafuran,parfuran,phenurin,piyeloseptyl,siraliden,trantoin,uerineks,urantoin,urizept,urodin,urofuran,urofurin,urolisa,urolong,uvamin,welfurin,zoofurin"	0.2	"g"			"18955-5,362-4,363-2,364-0,365-7,3860-4,7036-7"
+"NIT"	6604200	"Nitrofurantoin"	"Other antibacterials"	"J01XE01"	"Other antibacterials"	"Nitrofuran derivatives"	"f,f/m,fd,ft,ni,nit,nitr"	"alfuran,benkfuran,berkfuran,berkfurin,ceduran,chemiofuran,cistofuran,cyantin,cystit,dantafur,fuamed,furabid,furachel,furadantin,furadantinamc,furadantine,furadantinemc,furadantinretard,furadantoin,furadoin,furadoine,furadonin,furadonine,furadoninum,furadontin,furadoxyl,furalan,furaloid,furantoin,furantoina,furatoin,furedan,furina,furobactina,furodantin,furophent,gerofuran,ioussaixoo,ituran,ivadantin,macpac,macrobid,macrodantin,macrodantina,macrofuran,macrofurin,nierofu,nifurantin,nifuretten,nitoin,nitrex,nitrofuradantin,nitrofurantion,nitrofurantoina,nitrofurantoine,nitrofurantoinmacro,nitrofurantoinum,novofuran,orafuran,parfuran,phenurin,piyeloseptyl,siraliden,trantoin,uerineks,urantoin,urizept,urodin,urofuran,urofurin,urolisa,urolong,uvamin,welfurin,zoofurin"	0.2	"g"			"18955-5,362-4,363-2,364-0,365-7,3860-4,7036-7"
 "NIZ"	5447130	"Nitrofurazone"	"Other antibacterials"	"NA"			""	"acutol,aldomycin,alfucin,amifur,babrocid,becafurazone,biofuracina,biofurea,chemofuran,chixin,cocafurin,coxistat,dermofural,dymazone,dynazone,eldezol,fedacin,flavazone,fracine,furacilin,furacilinum,furacillin,furacin,furacine,furacinetten,furacoccid,furacort,furacycline,furaderm,furagent,furalcyn,furaldon,furalone,furametral,furaplast,furaseptyl,furaskin,furatsilin,furaziline,furazin,furazina,furazolw,furazone,furazyme,furesol,furfurin,furosem,fuvacillin,hemofuran,ibiofural,mammex,mastofuran,monafuracin,monafuracis,monofuracin,nfzmix,nifucin,nifurid,nifuzon,nitrofural,nitrofuralum,nitrofuran,nitrofurane,nitrofurazan,nitrofurazonum,nitrofurol,nitrozone,otofural,otofuran,rivafurazon,sanfuran,vabrocid,vadrocid,yatrocin"					"20388-5,87793-6"
 "NTR"	19910	"Nitroxoline"	"Quinolones"	"J01XX07"	"Other antibacterials"	"Other antibacterials"	""	"galinok,isinok,nibiol,niceneforte,nitroxlina,nitroxolin,nitroxolina,nitroxolinum,notroxoline,noxibiol"	1	"g"			"25608-1,25723-8,32382-4,54181-3,55688-6"
 "NOR"	4539	"Norfloxacin"	"Quinolones"	"J01MA06,S01AE02"	"Quinolone antibacterials"	"Fluoroquinolones"	"nor,norf,nx,nxn"	"baccidal,barazan,chibroxin,chibroxine,chibroxol,fulgram,gonorcin,lexinor,nolicin,noracin,noraxin,norflo,norfloxacine,norfloxacino,norfloxacinum,norocin,noroxin,noroxine,norxacin,sebercim,uroxacin,utinor,zoroxin"	0.8	"g"			"18956-3,366-5,367-3,368-1,369-9,3867-9,41504-2,7037-5"
@@ -298,8 +298,8 @@
 "NTI"		"Norfloxacin/tinidazole"	"Other antibacterials"	"J01RA13"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "NVA"	10419027	"Norvancomycin"	"Glycopeptides"	"NA"			""	""					""
 "NOV"	54675769	"Novobiocin"	"Other antibacterials"	"QJ01XX95"			"novo"	"albamix,albamycin,cardelmycin,cathocin,cathomycin,crystallinicacid,inamycin,novobiocina,novobiocine,novobiocinum,robiocina,sirbiocina,spheromycin,stilbiocina,streptonivicin"					"17378-1,18957-1,370-7,371-5,372-3,373-1,41706-3"
-"NYS"	6433272	"Nystatin"	"Antifungals/antimycotics"	"A07AA02,D01AA01,G01AA01"			"nyst"	"biofanal,candexlotion,comycin,diastatin,herniocid,moronal,myconystatin,mycostatin,mycostatinpastilles,mykinac,mykostatyna,nilstat,nistatin,nistatina,nyamyc,nyotran,nyotrantrademark,nystaform,nystan,nystatina,nystating,nystatinhydrate,nystatinlf,nystatine,nystatinum,nystatyna,nystavescent,nystex,nystop,stamycin,terrastatin,zydine"	1.5	"MU"			"10697-1,10698-9,18958-9,35824-2,55689-4"
+"NYS"	6433272	"Nystatin"	"Antifungals/antimycotics"	"A07AA02,D01AA01,G01AA01"			"nyst"	"biofanal,candexlotion,comycin,diastatin,herniocid,moronal,myconystatin,mycostatin,mycostatinpastilles,mykinac,mykostatyna,nilstat,nistatin,nistatina,nyamyc,nyotran,nyotrantrademark,nystaform,nystan,nystatina,nystatine,nystating,nystatinhydrate,nystatinlf,nystatinum,nystatyna,nystavescent,nystex,nystop,stamycin,terrastatin,zydine"	1.5	"MU"			"10697-1,10698-9,18958-9,35824-2,55689-4"
-"OFX"	4583	"Ofloxacin"	"Quinolones"	"J01MA01,S01AE01,S02AA16"	"Quinolone antibacterials"	"Fluoroquinolones"	"of,ofl,oflo,ofx"	"bactocin,danoflox,dextrofloxacin,effexin,exocin,exocine,flobacin,flodemex,flotavid,flovid,floxal,floxil,floxin,floxinotic,floxstat,fugacin,inoflox,kinflocin,kinoxacin,levofloxacinhcl,liflox,loxinter,marfloxacin,medofloxine,mergexin,monoflocet,novecin,nufafloqo,occidal,ocuflox,oflocee,oflocet,oflocin,oflodal,oflodex,oflodura,ofloxacinotic,ofloxacina,ofloxacine,ofloxacino,ofloxacinum,ofloxin,onexacin,operan,orocin,otonil,oxaldin,pharflox,praxin,puiritol,qinolon,quinolon,quotavil,sinflo,tabrin,taravid,tariflox,tarivid,telbit,tructum,urotarivid,viotisone,visiren,zanocin"	0.4	"g"	0.4	"g"	"18959-7,20384-4,23948-3,25264-3,374-9,375-6,376-4,377-2,3877-8,41408-6,41409-4,41410-2,42653-6,7038-3,72168-8"
+"OFX"	4583	"Ofloxacin"	"Quinolones"	"J01MA01,S01AE01,S02AA16"	"Quinolone antibacterials"	"Fluoroquinolones"	"of,ofl,oflo,ofx"	"bactocin,danoflox,dextrofloxacin,effexin,exocin,exocine,flobacin,flodemex,flotavid,flovid,floxal,floxil,floxin,floxinotic,floxstat,fugacin,inoflox,kinflocin,kinoxacin,levofloxacinhcl,liflox,loxinter,marfloxacin,medofloxine,mergexin,monoflocet,novecin,nufafloqo,occidal,ocuflox,oflocee,oflocet,oflocin,oflodal,oflodex,oflodura,ofloxacina,ofloxacine,ofloxacino,ofloxacinotic,ofloxacinum,ofloxin,onexacin,operan,orocin,otonil,oxaldin,pharflox,praxin,puiritol,qinolon,quinolon,quotavil,sinflo,tabrin,taravid,tariflox,tarivid,telbit,tructum,urotarivid,viotisone,visiren,zanocin"	0.4	"g"	0.4	"g"	"18959-7,20384-4,23948-3,25264-3,374-9,375-6,376-4,377-2,3877-8,41408-6,41409-4,41410-2,42653-6,7038-3,72168-8"
 "OOR"		"Ofloxacin/ornidazole"	"Other antibacterials"	"J01RA09"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "OLE"	72493	"Oleandomycin"	"Macrolides/lincosamides"	"J01FA05"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"amimycin,landomycin,matromycin,oleandomicina,oleandomycina,oleandomycine,oleandomycinum,romicil"	1	"g"			"18960-5,378-0,379-8,380-6,381-4,55690-2"
 "OMC"	54697325	"Omadacycline"	"Tetracyclines"	"J01AA15"			""	"amadacycline"	0.3	"g"	0.1	"g"	"73594-4,73616-5,73639-7"
@@ -309,13 +309,13 @@
 "ORS"		"Ormetroprim/sulfamethoxazole"	"Other antibacterials"	"NA"			""	""					"73593-6,73615-7,73638-9"
 "ORN"	28061	"Ornidazole"	"Other antibacterials"	"G01AF06,J01XD03,P01AB03"	"Other antibacterials"	"Imidazole derivatives"	""	"madelen,ornidal,ornidazol,ornidazolum,tiberal"	1.5	"g"	1	"g"	"55691-0,55692-8,55693-6,55694-4"
 "OTE"	77050711	"Oteseconazole"	"Antifungals/antimycotics"	"J02AC06"	"Antimycotics for systemic use"	"Triazole derivatives"	""	""	21	"mg"			""
-"OXA"	6196	"Oxacillin"	"Beta-lactams/penicillins"	"J01CF04"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"ox,oxa,oxac,oxal,oxs"	"bactocill,ossacillina,oxacilina,oxacillinsodium,oxacilline,oxacillinum,oxazocillin,oxazocilline,prostaphlin,prostaphlyn,sodiumoxacillin"	2	"g"	2	"g"	"18961-3,25265-0,382-2,383-0,384-8,385-5,3882-8,7039-1"
+"OXA"	6196	"Oxacillin"	"Beta-lactams/penicillins"	"J01CF04"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"ox,oxa,oxac,oxal,oxs"	"bactocill,ossacillina,oxacilina,oxacilline,oxacillinsodium,oxacillinum,oxazocillin,oxazocilline,prostaphlin,prostaphlyn,sodiumoxacillin"	2	"g"	2	"g"	"18961-3,25265-0,382-2,383-0,384-8,385-5,3882-8,7039-1"
 "OXO"	4628	"Oxolinic acid"	"Quinolones"	"J01MB05"	"Quinolone antibacterials"	"Other quinolones"	""	"acideoxolinique,acidoossolico,acidooxolinico,acidumoxolinicum,aqualinic,cistopax,dioxacin,emyrenil,gramurin,inoxyl,nidantin,oksaren,orthurine,ossian,oxoboi,oxolinic,oxolinicacid,pietil,prodoxal,prodoxol,starner,tiurasin,ultibid,urinox,uritrate,urotrate,uroxol,utibid"	1	"g"			""
-"OXY"	54675779	"Oxytetracycline"	"Tetracyclines"	"A01AB25,D06AA03,G01AA07,J01AA06,S01AA04"	"Tetracyclines"	"Tetracyclines"	""	"adamycin,berkmycen,biostat,biostatpa,bisolvomycin,dabicycline,dalimycin,embryostat,fanterrin,galsenomycin,geomycin,geotilin,hydroxytetracyclinum,imperacin,lenocycline,macocyn,medamycin,mepatar,oksisyklin,ossitetraciclina,oxacycline,oxitetraciclina,oxitetracyclin,oxitetracycline,oxitetracyclinum,oxydon,oxymycin,oxymykoin,oxypam,oxysteclin,oxyterracin,oxyterracine,oxyterracyne,oxytetracid,oxytetracyclin,oxytetracyclinebase,oxytetracyclinum,proteroxyna,riomitsin,ryomycin,solkaciclina,stecsolin,stevacin,tarocyn,tarosin,teravit,terrafungine,terramitsin,terramycin,terramycinim,terramycine,tetran,unimycin,ursocyclin,ursocycline,vendarcin"	1	"g"	1	"g"	"17396-3,18962-1,25266-8,386-3,387-1,388-9,389-7,55699-3,87595-5"
+"OXY"	54675779	"Oxytetracycline"	"Tetracyclines"	"A01AB25,D06AA03,G01AA07,J01AA06,S01AA04"	"Tetracyclines"	"Tetracyclines"	""	"adamycin,berkmycen,biostat,biostatpa,bisolvomycin,dabicycline,dalimycin,embryostat,fanterrin,galsenomycin,geomycin,geotilin,hydroxytetracyclinum,imperacin,lenocycline,macocyn,medamycin,mepatar,oksisyklin,ossitetraciclina,oxacycline,oxitetraciclina,oxitetracyclin,oxitetracycline,oxitetracyclinum,oxydon,oxymycin,oxymykoin,oxypam,oxysteclin,oxyterracin,oxyterracine,oxyterracyne,oxytetracid,oxytetracyclin,oxytetracyclinebase,oxytetracyclinum,proteroxyna,riomitsin,ryomycin,solkaciclina,stecsolin,stevacin,tarocyn,tarosin,teravit,terrafungine,terramitsin,terramycin,terramycine,terramycinim,tetran,unimycin,ursocyclin,ursocycline,vendarcin"	1	"g"	1	"g"	"17396-3,18962-1,25266-8,386-3,387-1,388-9,389-7,55699-3,87595-5"
 "OZN"		"Ozenoxacin"		"D06AX14"			""	"ozadub,ozenoxacincream"					""
 "PAS"	4649	"P-aminosalicylic acid"	"Antimycobacterials"	"NA"			""	"aminopar,aminosalicylic,aminosalicylicacid,aminosalyl,aminox,apacil,deapasil,entepas,ferrosan,gabbropas,granupas,helipidyl,hellipidyl,neopasalate,osacyl,pamacyl,pamisyl,paramycin,parasal,parasalicil,parasalindon,pasalon,pasara,pascorbic,pasdium,pasergranules,paskalium,pasmed,pasnodia,pasolac,propasa,rezipas,teebacin"					""
 "PAN"	72015	"Panipenem"	"Carbapenems"	"NA,J01DH55"			""	"panipenembetamipron,panipenemum,penipanem"			2	"g"	"100056-1,53823-1"
-"PAR"	165580	"Paromomycin"	"Other antibacterials"	"A07AA06"			""	"aminosidin,aminosidine,aminosidinei,aminosidinesulfate,amminosidin,crestomycin,estomycin,gabbromicina,gabbromycin,gabromycin,humatin,humycin,hydroxymycin,hydroxymycinsulfate,monomycin,monomycina,neomycine,paramomycin,paramomycinsulfate,paromomicina,paromomycini,paromomycine,paromomycinum,paucimycin,paucimycinum,quintomycinc"	3	"g"			"51719-3,53824-9,55700-9,55701-7,55702-5"
+"PAR"	165580	"Paromomycin"	"Other antibacterials"	"A07AA06"			""	"aminosidin,aminosidine,aminosidinei,aminosidinesulfate,amminosidin,crestomycin,estomycin,gabbromicina,gabbromycin,gabromycin,humatin,humycin,hydroxymycin,hydroxymycinsulfate,monomycin,monomycina,neomycine,paramomycin,paramomycinsulfate,paromomicina,paromomycine,paromomycini,paromomycinum,paucimycin,paucimycinum,quintomycinc"	3	"g"			"51719-3,53824-9,55700-9,55701-7,55702-5"
 "PAZ"	65957	"Pazufloxacin"	"Quinolones"	"J01MA18"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"pazufloxacine,pazufloxacino,pazufloxacinum"			1	"g"	""
 "PEF"	51081	"Pefloxacin"	"Quinolones"	"J01MA03"	"Quinolone antibacterials"	"Fluoroquinolones"	"pefl"	"abactal,labocton,pefloxacine,pefloxacinium,pefloxacino,pefloxacinum,perfloxacin,silverpefloxacin"	0.8	"g"	0.8	"g"	"18963-9,35828-3,390-5,3906-5,7040-9"
 "PNM"	10250769	"Penamecillin"	"Beta-lactams/penicillins"	"J01CE06"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	""	"hydroxymethyl,penamecilina,penamecillina,penamecilline,penamecillinum"	1.05	"g"			""
@@ -329,7 +329,7 @@
 "PHN"	6869	"Phenoxymethylpenicillin"	"Beta-lactams/penicillins"	"J01CE02"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	"fepe,peni v,penicillin v,pnv,pv"	"acipenv,apocillin,apopen,beromycin,calcipen,compocillinv,crystapenv,distaquainev,eskacillianv,eskacillinv,fenacilin,fenospen,meropenin,oracillin,oratren,pcpenvk,penicillinv,phenocillin,phenomycilline,phenopenicillin,robicillin,rocilin,stabicillin,vebecillin,veetids,vegacillin"	2	"g"			""
 "PMR"	5284447	"Pimaricin"	"Antifungals/antimycotics"	"NA"			"natamycin"	"delvocid,delvolan,delvopos,mycophyt,myprozine,natacyn,natafucin,natamicina,natamycin,natamycine,natamycinum,pimafucin,pimaracin,pimaricine,pimarizin,synogil,tennecetin"					""
 "PPA"	4831	"Pipemidic acid"	"Quinolones"	"J01MB04"	"Quinolone antibacterials"	"Other quinolones"	"pipz,pizu"	"acidepipemidique,acidopipemidico,acidumpipemidicum,deblaston,dolcol,filtrax,pipedac,pipemid,pipemidate,pipemidic,pipemidicacid,pipram,pipurin,tractur,uromidin,urosten,uroval"	0.8	"g"			""
-"PIP"	43672	"Piperacillin"	"Beta-lactams/penicillins"	"J01CA12"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"pi,pip,pipc,pipe,pp"	"isipen,pentcillin,peperacillin,peracin,piperacilina,piperacillinhydrate,piperacillinna,piperacillinsodium,piperacillina,piperacilline,piperacillinum,pipercillin,pipracil,pipril,tazocin"			14	"g"	"101490-1,101491-9,18969-6,18970-4,25268-4,3972-7,407-7,408-5,409-3,410-1,411-9,412-7,413-5,414-3,54197-9,54198-7,54199-5,55704-1,7043-3,7044-1"
+"PIP"	43672	"Piperacillin"	"Beta-lactams/penicillins"	"J01CA12"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"pi,pip,pipc,pipe,pp"	"isipen,pentcillin,peperacillin,peracin,piperacilina,piperacillina,piperacilline,piperacillinhydrate,piperacillinna,piperacillinsodium,piperacillinum,pipercillin,pipracil,pipril,tazocin"			14	"g"	"101490-1,101491-9,18969-6,18970-4,25268-4,3972-7,407-7,408-5,409-3,410-1,411-9,412-7,413-5,414-3,54197-9,54198-7,54199-5,55704-1,7043-3,7044-1"
 "PIS"		"Piperacillin/sulbactam"	"Beta-lactams/penicillins"	"NA"			""	""					"54197-9,54198-7,54199-5,55704-1"
 "TZP"	461573	"Piperacillin/tazobactam"	"Beta-lactams/penicillins"	"J01CR05"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	"p/t,piptaz,piptazo,pit,pita,pt,ptc,ptz,tzp"	"tazocel,tazocillin,tazocin,zosyn"			14	"g"	"101491-9,18970-4,411-9,412-7,413-5,414-3,7044-1"
 "PRC"	71978	"Piridicillin"	"Beta-lactams/penicillins"	"NA"			""	""					""
@@ -351,7 +351,7 @@
 "PKA"	9872451	"Propikacin"	"Aminoglycosides"	"NA"			""	"propikacina,propikacine,propikacinum"					""
 "PTH"	666418	"Protionamide"	"Antimycobacterials"	"J04AD01"	"Drugs for treatment of tuberculosis"	"Thiocarbamide derivatives"	"prot"	"ektebin,peteha,prothionamide,prothionamidum,protion,protionamid,protionamida,protionamidum,protionizina,tebeform,trevintix,tuberex"	0.75	"g"			""
 "PRU"	65947	"Prulifloxacin"	"Quinolones"	"J01MA17"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"pruvel,pufloxacindioxolil,quisnon"	0.6	"g"			"100058-7,76145-2"
-"PZA"	1046	"Pyrazinamide"	"Antimycobacterials"	"J04AK01"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"pyra"	"aldinamid,aldinamide,braccopiral,corsazinmid,dipimide,eprazin,farmizina,isopas,lynamide,novamid,pezetamid,pharozinamide,piraldina,pirazimida,pirazinamid,pirazinamida,pirazinamide,prazina,pyrafat,pyramide,pyrazide,pyrazinamdie,pyrazinamid,pyrazinamidum,pyrazinecarboxamide,pyrazineamide,pyrizinamide,rifafour,rozide,tebrazid,tebrazio,tisamid,unipyranamide,zinamide,zinastat"	1.5	"g"			"11001-5,18973-8,20461-0,23632-3,25186-8,25229-6,25270-0,423-4,424-2,425-9,426-7,42935-7,55710-8,55711-6,56026-8,92242-7"
+"PZA"	1046	"Pyrazinamide"	"Antimycobacterials"	"J04AK01"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"pyra"	"aldinamid,aldinamide,braccopiral,corsazinmid,dipimide,eprazin,farmizina,isopas,lynamide,novamid,pezetamid,pharozinamide,piraldina,pirazimida,pirazinamid,pirazinamida,pirazinamide,prazina,pyrafat,pyramide,pyrazide,pyrazinamdie,pyrazinamid,pyrazinamidum,pyrazineamide,pyrazinecarboxamide,pyrizinamide,rifafour,rozide,tebrazid,tebrazio,tisamid,unipyranamide,zinamide,zinastat"	1.5	"g"			"11001-5,18973-8,20461-0,23632-3,25186-8,25229-6,25270-0,423-4,424-2,425-9,426-7,42935-7,55710-8,55711-6,56026-8,92242-7"
 "QDA"	11979418	"Quinupristin/dalfopristin"	"Macrolides/lincosamides"	"QJ01FG02"	"Macrolides, lincosamides and streptogramins"	"Streptogramins"	"q/d,qda,qida,quda,rp,syn"	""					"23640-6,23641-4,33334-4,35835-8,58712-1"
 "RAC"	56052	"Ractopamine"	"Other antibacterials"	"NA"			""	"optaflexx,paylean,ractopamina,ractopaminum"					""
 "RAM"	16132338	"Ramoplanin"	"Glycopeptides"	"NA"			""	""					"41710-5,41711-3,41712-1,41737-8"
@@ -362,7 +362,7 @@
 "RST"	33042	"Ribostamycin"	"Aminoglycosides"	"J01GB10"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	""	"dekamyciniv,hetangmycin,ribastamin,ribostamicina,ribostamycine,ribostamycinum,vistamycin,xylostatin"			1	"g"	""
 "RID1"	16659285	"Ridinilazole"	"Other antibacterials"	"NA"			""	""					""
 "RIB"	135398743	"Rifabutin"	"Antimycobacterials"	"J04AB04"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"rifb"	"alfacid,ansamicin,ansamycin,ansatipin,ansatipine,assatipin,mycobutin,rifabutina,rifabutine,rifabutinum"	0.15	"g"			"100699-8,16100-0,16386-5,16387-3,19149-4,20386-9,23630-7,24032-5,25199-1,25200-7,25201-5,42655-1,42656-9,54183-9,96113-6"
-"RIF"	135398735	"Rifampicin"	"Antimycobacterials"	"J04AB02"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"rifa"	"abrifam,archidyn,arficin,arzide,aztrifampin,benemicin,benemycin,dipicin,doloresum,eremfat,famcin,fenampicin,rifadin,rifadiniv,rifadine,rifagen,rifaldazin,rifaldazine,rifaldin,rifamate,rifamicinamp,rifamor,rifampicinsv,rifampicina,rifampicine,rifampicinum,rifampin,rifamsolin,rifamycinamp,rifapiam,rifaprodin,rifcin,rifinah,rifobac,rifoldin,rifoldine,riforal,rimactan,rimactane,rimactazid,rimactizid,rimazid,rimycin,sinerdol,tubocin"	0.6	"g"	0.6	"g"	""
+"RIF"	135398735	"Rifampicin"	"Antimycobacterials"	"J04AB02"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"rifa"	"abrifam,archidyn,arficin,arzide,aztrifampin,benemicin,benemycin,dipicin,doloresum,eremfat,famcin,fenampicin,rifadin,rifadine,rifadiniv,rifagen,rifaldazin,rifaldazine,rifaldin,rifamate,rifamicinamp,rifamor,rifampicina,rifampicine,rifampicinsv,rifampicinum,rifampin,rifamsolin,rifamycinamp,rifapiam,rifaprodin,rifcin,rifinah,rifobac,rifoldin,rifoldine,riforal,rimactan,rimactane,rimactazid,rimactizid,rimazid,rimycin,sinerdol,tubocin"	0.6	"g"	0.6	"g"	""
 "REI"	135483893	"Rifampicin/ethambutol/isoniazid"	"Antimycobacterials"	"J04AM07"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
 "RFI"		"Rifampicin/isoniazid"	"Antimycobacterials"	"J04AM02"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	"rifinah,rimactazid"					""
 "RPEI"		"Rifampicin/pyrazinamide/ethambutol/isoniazid"	"Antimycobacterials"	"J04AM06"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
@@ -376,23 +376,23 @@
 "RLT"	54682938	"Rolitetracycline"	"Tetracyclines"	"J01AA09"	"Tetracyclines"	"Tetracyclines"	""	"bristacin,kinteto,reverin,rolitetraciclina,rolitetracyclinum,solvocillin,superciclin,synotodecin,synterin,syntetrex,syntetrin,transcycline,velacicline,velacycline"			0.35	"g"	"18976-1,435-8,436-6,437-4,438-2"
 "ROS"	287180	"Rosoxacin"	"Quinolones"	"J01MB01"	"Quinolone antibacterials"	"Other quinolones"	""	"acrosoxacin,eracine,eradacil,eradacin,eradicin,rosoxacine,rosoxacino,rosoxacinum,roxadyl,winoxacin,winuron"	0.3	"g"			"18977-9,439-0,440-8,441-6,442-4,55713-2"
 "RXT"		"Roxithromycin"	"Macrolides/lincosamides"	"J01FA06"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"roxi"	"roxithromycine,roxithromycinum,roxitromicina,rulide"	0.3	"g"			"18978-7,443-2,444-0,445-7,446-5,7046-6"
-"RFL"	58258	"Rufloxacin"	"Quinolones"	"J01MA10"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"rufloxacinhcl,rufloxacine,rufloxacino,rufloxacinum"	0.2	"g"			""
+"RFL"	58258	"Rufloxacin"	"Quinolones"	"J01MA10"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"rufloxacine,rufloxacinhcl,rufloxacino,rufloxacinum"	0.2	"g"			""
 "SAL"	3085092	"Salinomycin"	"Other antibacterials"	"QP51BB01"			""	"coxistac,procoxacin,salinomicina,salinomycine,salinomycinum"					"35836-6,35837-4,35838-2,87593-0"
 "SAR"	56208	"Sarafloxacin"	"Quinolones"	"QJ01MA98"			""	"difloxacine,difloxacino,difloxacinum,quinoloneder,saraflox,sarafloxacine,sarafloxacino,sarafloxacinum"					"73588-6,73610-8,73633-0"
 "SRC"	54681908	"Sarecycline"	"Tetracyclines"	"J01AA14"	"Tetracyclines"	"Tetracyclines"	""	"seysara"	0.1	"g"			""
 "SRX"	9933415	"Sarmoxicillin"	"Beta-lactams/penicillins"	"NA"			""	""					""
 "SEC"	71815	"Secnidazole"	"Other antibacterials"	"P01AB07"			""	"flagentyl,secnidal,secnidazol,secnidazolum,secnil,sindose,solosec"	2	"g"			""
 "SMF"		"Simvastatin/fenofibrate"	"Antimycobacterials"	"C10BA04"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"simv"	""					""
-"SIS"	36119	"Sisomicin"	"Aminoglycosides"	"J01GB08"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"siso"	"rickamicin,salvamina,siseptinsulfate,sisomicinsulfate,sisomicina,sisomicine,sisomicinum,sisomin,sisomycin,sissomicin,sizomycin"			0.24	"g"	"18979-5,447-3,448-1,449-9,450-7,55714-0"
+"SIS"	36119	"Sisomicin"	"Aminoglycosides"	"J01GB08"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"siso"	"rickamicin,salvamina,siseptinsulfate,sisomicina,sisomicine,sisomicinsulfate,sisomicinum,sisomin,sisomycin,sissomicin,sizomycin"			0.24	"g"	"18979-5,447-3,448-1,449-9,450-7,55714-0"
 "SIT"	461399	"Sitafloxacin"	"Quinolones"	"J01MA21"			""	"gracevit,sitafloxacinisomer"	0.1	"g"			""
-"SDA"	2724368	"Sodium aminosalicylate"	"Antimycobacterials"	"J04AA02"	"Drugs for treatment of tuberculosis"	"Aminosalicylic acid and derivatives"	""	"bactylan,decapasil,lepasen,monopas,nippas,passodium,pamisylsodium,parasalsodium,pasade,pasnal,passodico,salvis,sanipirol,sodiopas,sodiumpas,teebacin,tubersan"	14	"g"	14	"g"	""
+"SDA"	2724368	"Sodium aminosalicylate"	"Antimycobacterials"	"J04AA02"	"Drugs for treatment of tuberculosis"	"Aminosalicylic acid and derivatives"	""	"bactylan,decapasil,lepasen,monopas,nippas,pamisylsodium,parasalsodium,pasade,pasnal,passodico,passodium,salvis,sanipirol,sodiopas,sodiumpas,teebacin,tubersan"	14	"g"	14	"g"	""
 "SOL"	25242512	"Solithromycin"	"Macrolides/lincosamides"	"J01FA16"			""	"solithera"					"73587-8,73609-0,73632-2"
 "SPX"	60464	"Sparfloxacin"	"Quinolones"	"J01MA09"	"Quinolone antibacterials"	"Fluoroquinolones"	"spa,spar"	"esparfloxacino,sparfloxacine,sparfloxacinum"	0.2	"g"			"20397-6,23610-9,23628-1,35839-0,7047-4"
 "SPT"	15541	"Spectinomycin"	"Other antibacterials"	"J01XX04"	"Other antibacterials"	"Other antibacterials"	"sc,spe,spec,spt"	"actinospectacina,adspec,espectinomicina,prospec,specitinomycin,spectam,spectinomicina,spectinomycindihcl,spectinomycine,spectinomycinum,stanilo,togamycin,trobicin"			3	"g"	"18980-3,35840-8,451-5,452-3,453-1,454-9"
 "SPI"	6419898	"Spiramycin"	"Macrolides/lincosamides"	"J01FA02"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"spir"	"espiramicin,provamycin,rovamycin,rovamycine,sequamycin,spiramycine,spiramycinum"	3	"g"			"18981-1,455-6,456-4,457-2,458-0,55715-7"
 "SPM"		"Spiramycin/metronidazole"	"Other antibacterials"	"J01RA04"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "STR"		"Streptoduocin"	"Aminoglycosides"	"J01GA02"	"Aminoglycoside antibacterials"	"Streptomycins"	""	"ambistrin"			1	"g"	""
-"STR1"	19649	"Streptomycin"	"Aminoglycosides"	"A07AA04,J01GA01"	"Aminoglycoside antibacterials"	"Streptomycins"	"s,stm,str,stre"	"agrept,agrimycin,chemform,estreptomicina,neodiestreptopab,strepcen,streptomicina,streptomycina,streptomycinspx,streptomycinsulfate,streptomycine,streptomycinum,streptomyzin,vetstrep"			1	"g"	"18982-9,18983-7,20462-8,23626-5,25185-0,25205-6,25206-4,35841-6,4039-4,42658-5,42659-3,459-8,460-6,461-4,462-2,46719-1,48177-0,6933-6,7048-2,7049-0,96114-4"
+"STR1"	19649	"Streptomycin"	"Aminoglycosides"	"A07AA04,J01GA01"	"Aminoglycoside antibacterials"	"Streptomycins"	"s,stm,str,stre"	"agrept,agrimycin,chemform,estreptomicina,neodiestreptopab,strepcen,streptomicina,streptomycina,streptomycine,streptomycinspx,streptomycinsulfate,streptomycinum,streptomyzin,vetstrep"			1	"g"	"18982-9,18983-7,20462-8,23626-5,25185-0,25205-6,25206-4,35841-6,4039-4,42658-5,42659-3,459-8,460-6,461-4,462-2,46719-1,48177-0,6933-6,7048-2,7049-0,96114-4"
 "STH"		"Streptomycin-high"	"Aminoglycosides"	"NA"			"sthi,sthl,strepto high,streptomycin high"	""					"18983-7,35841-6,6933-6,7049-0"
 "STI"		"Streptomycin/isoniazid"	"Antimycobacterials"	"J04AM01"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
 "SUL"	130313	"Sulbactam"	"Beta-lactams/penicillins"	"J01CG01"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase inhibitors"	""	"betamaze,sulbactamacid,sulbactamfreeacid,sulbactamum"			1	"g"	"41716-2,41717-0,41718-8,41739-4"
@@ -446,17 +446,18 @@
 "TRB"	1549008	"Terbinafine"	"Antifungals/antimycotics"	"D01AE15,D01BA02"	"Antifungals for systemic use"	"Antifungals for systemic use"	"terb"	"corbinal,lamasil,lamisil,lamisilat,lamisiltablet,terbinafina,terbinafinum,terbinex"	0.25	"g"			"10720-1,10721-9,18992-8"
 "TRC"	441383	"Terconazole"	"Antifungals/antimycotics"	"G01AG02"			""	"fungistat,panlomyc,terazol,terconazol,terconazolum,tercospor,triaconazole,zazole"					"55196-0"
 "TRZ"	65720	"Terizidone"	"Antimycobacterials"	"J04AK03"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	""	"terivalidin,terizidon,terizidona,terizidonum"					""
-"TCY"	54675776	"Tetracycline"	"Tetracyclines"	"A01AB13,D06AA04,J01AA07,S01AA09,S02AA08,S03AA02"	"Tetracyclines"	"Tetracyclines"	"tc,te,tet,tetr"	"abramycin,abricycline,achromycin,achromycinv,actisite,agromicina,ambramicina,ambramycin,amycin,biocycline,bristaciclin,bristaciclina,bristacycline,brodspec,cefracycline,centet,ciclibion,copharlan,criseociclina,cyclomycin,cyclopar,cytome,democracin,deschlorobiomycin,dumocyclin,economycin,enterocycline,hostacyclin,lexacycline,limecycline,liquamycin,medocycline,mericycline,micycline,neocycline,oletetrin,omegamycin,orlycycline,panmycin,piracaps,polycycline,polyotic,purocyclina,resteclin,robitet,roviciclina,sigmamycin,solvocin,sumycin,sumycinsyrup,supramycin,sustamycin,tetrabidorganon,tetrabon,tetrachel,tetraciclina,tetracycl,tetracyclin,tetracyclinebase,tetracyclinei,tetracyclineii,tetracyclinehydrate,tetracyclinum,tetracyn,tetradecin,tetrafil,tetramed,tetrasure,tetraverine,tetrazyklin,tetrex,topicycline,tsiklomistsin,tsiklomitsin,veracin,vetacyclinum,vetquamycin"	1	"g"	1	"g"	"101504-9,18993-6,25272-6,4045-1,495-2,496-0,497-8,498-6,7052-4,87590-6"
+"TCY"	54675776	"Tetracycline"	"Tetracyclines"	"A01AB13,D06AA04,J01AA07,S01AA09,S02AA08,S03AA02"	"Tetracyclines"	"Tetracyclines"	"tc,te,tet,tetr"	"abramycin,abricycline,achromycin,achromycinv,actisite,agromicina,ambramicina,ambramycin,amycin,biocycline,bristaciclin,bristaciclina,bristacycline,brodspec,cefracycline,centet,ciclibion,copharlan,criseociclina,cyclomycin,cyclopar,cytome,democracin,deschlorobiomycin,dumocyclin,economycin,enterocycline,hostacyclin,lexacycline,limecycline,liquamycin,medocycline,mericycline,micycline,neocycline,oletetrin,omegamycin,orlycycline,panmycin,piracaps,polycycline,polyotic,purocyclina,resteclin,robitet,roviciclina,sigmamycin,solvocin,sumycin,sumycinsyrup,supramycin,sustamycin,tetrabidorganon,tetrabon,tetrachel,tetraciclina,tetracycl,tetracyclin,tetracyclinebase,tetracyclinehydrate,tetracyclinei,tetracyclineii,tetracyclinum,tetracyn,tetradecin,tetrafil,tetramed,tetrasure,tetraverine,tetrazyklin,tetrex,topicycline,tsiklomistsin,tsiklomitsin,veracin,vetacyclinum,vetquamycin"	1	"g"	1	"g"	"101504-9,18993-6,25272-6,4045-1,495-2,496-0,497-8,498-6,7052-4,87590-6"
 "TOL"	54691494	"Tetracycline/oleandomycin"	"Other antibacterials"	"J01RA08"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "TET"	65450	"Tetroxoprim"	"Other antibacterials"	"NA"			""	"tetroxoprima,tetroxoprime,tetroxoprimum"					""
 "THA"	9568512	"Thiacetazone"	"Oxazolidinones"	"NA"			""	"aktivan,ambathizon,amithiozone,amithizone,amitiozon,benthiozone,benzothiozane,benzothiozon,berculona,berkazon,citazone,conteben,diasan,diazan,domakol,ilbion,livazone,mirizoneneustab,mivizon,myvizone,neotibil,neustab,novakol,nuclonargentinian,panrone,parazone,seroden,siocarbazone,tebalon,tebecure,tebemar,tebesonei,tebethion,tebethione,tebezon,thiacetone,thiacetozone,thibon,thibone,thioacetazon,thioacetazonum,thioazetazone,thiocarbazil,thiomicid,thionicid,thioparamizon,thioparamizone,thiosemicarbarzone,thiosemicarbazone,thiotebesin,thiotebezin,thiotebicina,thizone,tiacetazon,tibicur,tibion,tibione,tibizan,tibone,tioacetazon,tioacetazona,tioatsetazon,tiobicina,tiocarone,tiosecolo,tubercazon,tubigal"					"32384-0,54184-7,54204-3"
 "THI"	27200	"Thiamphenicol"	"Phenicols"	"J01BA02"	"Amphenicols"	"Amphenicols"	""	"descocin,dexawin,dextrosulfenidol,dextrosulphenidol,efnicol,hyrazin,igralin,macphenicol,masatirin,neomyson,racefenicol,racefenicolo,racefenicolum,raceophenidol,racephenicol,rincrol,thiamcol,thiamphenicolum,thiocymetin,thiomycetin,thiophenicol,tiamfenicol,tiamfenicolo,urfamicina,urfamycine,vicemycetin"	1.5	"g"	1.5	"g"	"41723-8,41724-6,41725-3,54169-8"
 "TAT"	9568512	"Thioacetazone"	"Antimycobacterials"	"J04AK07"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	""	"aktivan,ambathizon,amithiozone,amitiozon,benthiozone,benzothiozane,benzothiozon,berculona,berkazon,citazone,conteben,diasan,domakol,ilbion,livazone,mirizoneneustab,mivizon,myvizone,neotibil,neustab,novakol,nuclonargentinian,panrone,parazone,seroden,siocarbazone,tebalon,tebecure,tebemar,tebesonei,tebethion,tebethione,tebezon,thiacetone,thiacetozone,thibon,thibone,thioacetazon,thioacetazonum,thioazetazone,thiocarbazil,thiomicid,thionicid,thioparamizon,thioparamizone,thiosemicarbarzone,thiosemicarbazone,thiotebesin,thiotebezin,thiotebicina,thizone,tiacetazon,tibicur,tibion,tibione,tibizan,tibone,tioacetazon,tioacetazona,tioatsetazon,tiobicina,tiocarone,tiosecolo,tubercazon,tubigal"					""
 "THI1"		"Thioacetazone/isoniazid"	"Antimycobacterials"	"J04AM04"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
-"TIA"	656958	"Tiamulin"	"Other antibacterials"	"QJ01XQ01"			""	"denagard,thiamutilin,tiamulinpamoate,tiamulina,tiamuline,tiamulinum,tiavetp"					"35846-5,35847-3,35848-1,87589-8"
+"TIA"	656958	"Tiamulin"	"Other antibacterials"	"QJ01XQ01"			""	"denagard,thiamutilin,tiamulina,tiamuline,tiamulinpamoate,tiamulinum,tiavetp"					"35846-5,35847-3,35848-1,87589-8"
 "TIC"	36921	"Ticarcillin"	"Beta-lactams/penicillins"	"J01CA13"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"tc,ti,tic,tica"	"ticarcilina,ticarcilline,ticarcillinum,ticillin,timentin"			15	"g"	"18994-4,18995-1,25254-4,4054-3,4055-0,499-4,500-9,501-7,502-5,503-3,504-1,505-8,506-6,55716-5,55717-3,55718-1,55719-9,7053-2,7054-0"
 "TCC"	6437075	"Ticarcillin/clavulanic acid"	"Beta-lactams/penicillins"	"J01CR03"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	"t/c,tcc,ticl,tim,tlc"	"timentin"			15	"g"	""
 "TGC"	54686904	"Tigecycline"	"Tetracyclines"	"J01AA12"	"Tetracyclines"	"Tetracyclines"	"tgc,tig,tige"	"haizhenglixing,tigeciclina,tigecyclin,tigecyclinehydrate,tigecyclinum,tigilcycline,tygacil"			0.1	"g"	"101499-2,42354-1,42355-8,42356-6,42357-4,55158-0"
+"TMN"		"Tigemonam"	"Monobactams"	"NA"			""	""					""
 "TBQ"	65592	"Tilbroquinol"	"Quinolones"	"P01AA05"			""	"tilbroquinolum"					""
 "TIP"	24860548	"Tildipirosin"	"Macrolides/lincosamides"	"QJ01FA96"			""	"zuprevo"					"100060-3,88375-1,88377-7"
 "TIL"	5282521	"Tilmicosin"	"Macrolides/lincosamides"	"QJ01FA91"			""	"micotil,pulmotil,tilmicosina,tilmicosine,tilmicosinum"					"35849-9,35850-7,35851-5,87588-0"
@@ -465,11 +466,11 @@
 "TDC"	10247721	"Tiodonium chloride"	"Other antibacterials"	"NA"			""	"clorurodetiodonio,tiodoniichloridum,tiodoniumchloride"					""
 "TXC"	65788	"Tioxacin"	"Quinolones"	"NA"			""	"tioxacine,tioxacino,tioxacinum,tioxicacid"					""
 "TIZ"	394397	"Tizoxanide"	"Other antibacterials"	"NA"			""	"ntzdes"					"73585-2,73607-4,73629-8"
-"TOB"	36294	"Tobramycin"	"Aminoglycosides"	"J01GB01,S01AA12"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"nn,tm,to,tob,tobr"	"bethkis,brulamycin,deoxykanamycinb,distobram,gernebcin,gotabiotic,kitabis,kitabispak,nebcin,nebicin,nebramycin,nebramycinvi,obramycin,sybryx,tenebrimycin,tenemycin,tobacin,tobipodhaler,tobracin,tobradex,tobradistin,tobralex,tobramaxin,tobramicin,tobramicina,tobramitsetin,tobramycetin,tobramycinbase,tobramycinsulfate,tobramycine,tobramycinum,tobrased,tobrasone,tobrex"			0.24	"g"	"101496-8,13584-8,17808-7,18996-9,22750-4,22751-2,22752-0,25227-0,25800-4,31094-6,31095-3,31096-1,35239-3,35670-9,4057-6,4058-4,4059-2,507-4,508-2,509-0,50927-3,510-8,52962-8,59380-6,7055-7,80966-5"
+"TOB"	36294	"Tobramycin"	"Aminoglycosides"	"J01GB01,S01AA12"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"nn,tm,to,tob,tobr"	"bethkis,brulamycin,deoxykanamycinb,distobram,gernebcin,gotabiotic,kitabis,kitabispak,nebcin,nebicin,nebramycin,nebramycinvi,obramycin,sybryx,tenebrimycin,tenemycin,tobacin,tobipodhaler,tobracin,tobradex,tobradistin,tobralex,tobramaxin,tobramicin,tobramicina,tobramitsetin,tobramycetin,tobramycinbase,tobramycine,tobramycinsulfate,tobramycinum,tobrased,tobrasone,tobrex"			0.24	"g"	"101496-8,13584-8,17808-7,18996-9,22750-4,22751-2,22752-0,25227-0,25800-4,31094-6,31095-3,31096-1,35239-3,35670-9,4057-6,4058-4,4059-2,507-4,508-2,509-0,50927-3,510-8,52962-8,59380-6,7055-7,80966-5"
 "TOH"		"Tobramycin-high"	"Aminoglycosides"	"NA"			"tobra high,tobramycin high,tohl"	""					""
 "TFX"	5517	"Tosufloxacin"	"Quinolones"	"J01MA22,S01AE09"			""	""	0.45	"g"			"100061-1,76146-0"
 "TMP"	5578	"Trimethoprim"	"Trimethoprims"	"J01EA01"	"Sulfonamides and trimethoprim"	"Trimethoprim and derivatives"	"t,tmp,tr,tri,trim,w"	"abaprim,alprim,anitrim,antrima,antrimox,bacdan,bacidal,bacide,bacterial,bacticel,bactifor,bactin,bactoprim,bactramin,bactrim,bencole,bethaprim,biosulten,briscotrim,chemotrin,colizole,colizoleds,conprim,cotrimel,cotrimoxizole,deprim,dosulfin,duocide,esbesul,espectrin,euctrim,exbesul,fermagex,fortrim,idotrim,ikaprim,infectotrimet,instalac,kombinax,lagatrim,lagatrimforte,lastrim,lescot,methoprim,metoprim,monoprim,monotrim,monotrimin,novotrimel,omstat,oraprim,pancidim,polytrim,priloprim,primosept,primsol,proloprim,protrin,purbal,resprim,resprimforte,roubac,roubal,salvatrim,septrinds,septrinforte,septrins,setprin,sinotrim,stopan,streptoplus,sugaprim,sulfamar,sulfamethoprim,sulfoxaprim,sulthrim,sultrex,syraprim,tiempe,tmpsmx,toprim,trimanyl,trimethioprim,trimethopim,trimethoprime,trimethoprimum,trimethopriom,trimetoprim,trimetoprima,trimexazole,trimexol,trimezol,trimogal,trimono,trimopan,trimpex,triprim,trisul,trisulcom,trisulfam,trisural,uretrim,urobactrim,utetrin,velaten,wellcoprim,wellcoprin,xeroprim,zamboprim"	0.4	"g"	0.4	"g"	"101495-0,11005-6,17747-7,18997-7,18998-5,20387-7,23614-1,23631-5,25273-4,32342-8,4079-0,4080-8,4081-6,511-6,512-4,513-2,514-0,515-7,516-5,517-3,518-1,55584-7,7056-5,7057-3,80552-3,80973-1"
-"SXT"	358641	"Trimethoprim/sulfamethoxazole"	"Trimethoprims"	"J01EE01"	"Sulfonamides and trimethoprim"	"Combinations of sulfonamides and trimethoprim, incl. derivatives"	"cot,cotrim,sxt,t/s,tms,trsu,trsx,ts"	"abacin,abactrim,agoprim,alfatrim,aposulfatrim,bacteral,bacterialforte,bactilen,bactiver,bacton,bactoreduct,bactrim,bactrimds,bactrimforte,bactrimpediatric,bactrimel,bactrizol,bactromin,bactropin,baktar,belcomycine,berlocid,bibacrim,biseptol,chemitrim,chemotrim,ciplin,colimycin,colimycinsulphate,colisticin,colistimethate,colistimethatesodium,colistinsulfate,colistinsulphate,colomycin,colymycin,cotribene,cotrimds,cotrimeurho,cotrimholsen,cotrimlut,cotrimaxazol,cotrimazole,cotrimhexal,cotrimoxazol,cotrimoxazolal,cotrimoxazole,cotrimstada,cotriver,dibaprim,drylin,duratrimet,eltrianyl,escoprim,esteprim,eusaprim,fectrim,gantaprim,gantaprin,gantrim,groprim,helveprim,imexim,jenamoxazol,kemoprim,kepinol,kepinolforte,laratrim,linaris,maxtrim,microtrim,microtrimforte,mikrosid,momentol,oecotrim,oriprim,oxaprim,pantoprim,polymyxine,polymyxinesulfate,primazole,promixin,septra,septrads,septragrape,septrim,septrin,servitrim,sigaprim,sigaprin,sulfatrimpediatric,sulfotrim,sulfotrimin,sulmeprimpediatric,sulprim,sumetrolim,supracombin,suprim,tacumil,teleprim,teleprin,thiocuran,totazina,tribakin,trifen,trigonyl,trimesulf,trimethocomp,trimethoprimsulfa,trimetoger,trimexazol,trimforte,trimosulfa,uroplus,uroplusds,uroplusss"					"101495-0,18998-5,20387-7,23631-5,25273-4,32342-8,4081-6,515-7,516-5,517-3,518-1,7057-3"
+"SXT"	358641	"Trimethoprim/sulfamethoxazole"	"Trimethoprims"	"J01EE01"	"Sulfonamides and trimethoprim"	"Combinations of sulfonamides and trimethoprim, incl. derivatives"	"cot,cotrim,sxt,t/s,tms,trsu,trsx,ts"	"abacin,abactrim,agoprim,alfatrim,aposulfatrim,bacteral,bacterialforte,bactilen,bactiver,bacton,bactoreduct,bactrim,bactrimds,bactrimel,bactrimforte,bactrimpediatric,bactrizol,bactromin,bactropin,baktar,belcomycine,berlocid,bibacrim,biseptol,chemitrim,chemotrim,ciplin,colimycin,colimycinsulphate,colisticin,colistimethate,colistimethatesodium,colistinsulfate,colistinsulphate,colomycin,colymycin,cotribene,cotrimaxazol,cotrimazole,cotrimds,cotrimeurho,cotrimhexal,cotrimholsen,cotrimlut,cotrimoxazol,cotrimoxazolal,cotrimoxazole,cotrimstada,cotriver,dibaprim,drylin,duratrimet,eltrianyl,escoprim,esteprim,eusaprim,fectrim,gantaprim,gantaprin,gantrim,groprim,helveprim,imexim,jenamoxazol,kemoprim,kepinol,kepinolforte,laratrim,linaris,maxtrim,microtrim,microtrimforte,mikrosid,momentol,oecotrim,oriprim,oxaprim,pantoprim,polymyxine,polymyxinesulfate,primazole,promixin,septra,septrads,septragrape,septrim,septrin,servitrim,sigaprim,sigaprin,sulfatrimpediatric,sulfotrim,sulfotrimin,sulmeprimpediatric,sulprim,sumetrolim,supracombin,suprim,tacumil,teleprim,teleprin,thiocuran,totazina,tribakin,trifen,trigonyl,trimesulf,trimethocomp,trimethoprimsulfa,trimetoger,trimexazol,trimforte,trimosulfa,uroplus,uroplusds,uroplusss"					"101495-0,18998-5,20387-7,23631-5,25273-4,32342-8,4081-6,515-7,516-5,517-3,518-1,7057-3"
 "TRL"	202225	"Troleandomycin"	"Macrolides/lincosamides"	"J01FA08"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"acetyloleandomycin,aovine,cyclamycin,evramicina,matromicina,matromycint,micotil,oleandocetine,tao,treolmicina,tribiocillina,triocetin,triolan,troleandomicina,troleandomycine,troleandomycinum,viamicina,wytrion"	1	"g"			"18999-3,519-9,520-7,521-5,522-3"
 "TRO"	55886	"Trospectomycin"	"Other antibacterials"	"NA"			""	"rubidiumnitrate,trospectinomycin,trospectomicina,trospectomycine,trospectomycinum"					""
 "TVA"	62959	"Trovafloxacin"	"Quinolones"	"J01MA13"	"Quinolone antibacterials"	"Fluoroquinolones"	"trov"	"trovan"	0.2	"g"	0.2	"g"	"23642-2,23643-0,35855-6,7058-1"
@@ -477,7 +478,7 @@
 "TYL"	5280440	"Tylosin"	"Macrolides/lincosamides"	"QJ01FA90,QJ51FA90"			""	"fradizine,tilosina,tylocine,tylosina,tylosine,tylosinum"					"35856-4,35857-2,35858-0,87587-2"
 "TYL1"	6441094	"Tylvalosin"	"Macrolides/lincosamides"	"QJ01FA92"			"tvn"	""					"101526-2,87586-4"
 "PRU1"	124225	"Ulifloxacin (Prulifloxacin)"	"Other antibacterials"	"NA"			""	"ulifloxacin"					""
-"VAN"	14969	"Vancomycin"	"Glycopeptides"	"A07AA09,J01XA01,S01AA28"	"Other antibacterials"	"Glycopeptide antibacterials"	"va,van,vanc"	"vancocin,vancocinhcl,vancoled,vancomicina,vancomycinhcl,vancomycine,vancomycinum,vancor,viomycinderivative"	2	"g"	2	"g"	"13586-3,13587-1,19000-9,20578-1,23615-8,25228-8,31012-8,39092-2,39796-8,39797-6,4089-9,4090-7,4091-5,4092-3,50938-0,523-1,524-9,525-6,526-4,59381-4,7059-9,92241-9,97657-1"
+"VAN"	14969	"Vancomycin"	"Glycopeptides"	"A07AA09,J01XA01,S01AA28"	"Other antibacterials"	"Glycopeptide antibacterials"	"va,van,vanc"	"vancocin,vancocinhcl,vancoled,vancomicina,vancomycine,vancomycinhcl,vancomycinum,vancor,viomycinderivative"	2	"g"	2	"g"	"13586-3,13587-1,19000-9,20578-1,23615-8,25228-8,31012-8,39092-2,39796-8,39797-6,4089-9,4090-7,4091-5,4092-3,50938-0,523-1,524-9,525-6,526-4,59381-4,7059-9,92241-9,97657-1"
 "VAM"		"Vancomycin-macromethod"	"Glycopeptides"	"NA"			""	""					""
 "VIO"	135398671	"Viomycin"	"Antimycobacterials"	"NA"			""	"celiomycin,florimycin,floromycin,tuberactinomycinb,vinacetina,vioactane,viomicina,viomycine,viomycinum"					"19001-7,23616-6,527-2,528-0,529-8,530-6"
 "VIR"	11979535	"Virginiamycine"	"Other antibacterials"	"NA"			""	"eskalin,eskalinv,micamicina,mikamycin,mikamycine,mikamycinum,ostreogricina,ostreogrycin,ostreogrycine,ostreogrycinum,pristinamicina,pristinamycine,pristinamycinum,pyostacine,stafac,stafytracine,staphylomycin,stapyocine,starfac,streptogramin,vernamycin,virgimycin,virgimycine,virginiamicina,virginiamycin,virginiamycina,virginiamycinum"					""

data-raw/reproduction_of_clinical_breakpoints.R

@@ -269,8 +269,8 @@ breakpoints_new <- breakpoints %>%
   ) %>%
   # Greek symbols and EM dash symbols are not allowed by CRAN, so replace them with ASCII:
   mutate(disk_dose = disk_dose %>%
-    gsub("μ", "u", ., fixed = TRUE) %>% # this is 'mu', \u03bc
+    gsub("μ", "mc", ., fixed = TRUE) %>% # this is 'mu', \u03bc
-    gsub("µ", "u", ., fixed = TRUE) %>% # this is 'micro', u00b5 (yes, they look the same)
+    gsub("µ", "mc", ., fixed = TRUE) %>% # this is 'micro', \u00b5 (yes, they look the same)
     gsub("–", "-", ., fixed = TRUE)) %>%
   arrange(desc(guideline), mo, ab, type, method) %>%
   filter(!(is.na(breakpoint_S) & is.na(breakpoint_R)) & !is.na(mo) & !is.na(ab)) %>%

man/antibiotics.Rd

@@ -4,9 +4,9 @@
 \name{antibiotics}
 \alias{antibiotics}
 \alias{antivirals}
-\title{Data Sets with 606 Antimicrobial Drugs}
+\title{Data Sets with 607 Antimicrobial Drugs}
 \format{
-\subsection{For the \link{antibiotics} data set: a \link[tibble:tibble]{tibble} with 486 observations and 14 variables:}{
+\subsection{For the \link{antibiotics} data set: a \link[tibble:tibble]{tibble} with 487 observations and 14 variables:}{
 \itemize{
 \item \code{ab}\cr Antibiotic ID as used in this package (such as \code{AMC}), using the official EARS-Net (European Antimicrobial Resistance Surveillance Network) codes where available. \emph{\strong{This is a unique identifier.}}
 \item \code{cid}\cr Compound ID as found in PubChem. \emph{\strong{This is a unique identifier.}}

man/antimicrobial_class_selectors.Rd

@@ -19,9 +19,11 @@
 \alias{cephalosporins_5th}
 \alias{fluoroquinolones}
 \alias{glycopeptides}
+\alias{isoxazolylpenicillins}
 \alias{lincosamides}
 \alias{lipoglycopeptides}
 \alias{macrolides}
+\alias{monobactams}
 \alias{nitrofurans}
 \alias{oxazolidinones}
 \alias{penicillins}
@@ -78,6 +80,8 @@ fluoroquinolones(only_sir_columns = FALSE, return_all = TRUE, ...)
 
 glycopeptides(only_sir_columns = FALSE, return_all = TRUE, ...)
 
+isoxazolylpenicillins(only_sir_columns = FALSE, return_all = TRUE, ...)
+
 lincosamides(only_sir_columns = FALSE, only_treatable = TRUE,
   return_all = TRUE, ...)
 
@@ -85,6 +89,8 @@ lipoglycopeptides(only_sir_columns = FALSE, return_all = TRUE, ...)
 
 macrolides(only_sir_columns = FALSE, return_all = TRUE, ...)
 
+monobactams(only_sir_columns = FALSE, return_all = TRUE, ...)
+
 nitrofurans(only_sir_columns = FALSE, return_all = TRUE, ...)
 
 oxazolidinones(only_sir_columns = FALSE, return_all = TRUE, ...)
@@ -167,23 +173,25 @@ The \code{\link[=not_intrinsic_resistant]{not_intrinsic_resistant()}} function c
 \item \code{\link[=aminopenicillins]{aminopenicillins()}} can select: \cr amoxicillin (AMX) and ampicillin (AMP)
 \item \code{\link[=antifungals]{antifungals()}} can select: \cr amorolfine (AMO), amphotericin B (AMB), amphotericin B-high (AMH), anidulafungin (ANI), butoconazole (BUT), caspofungin (CAS), ciclopirox (CIX), clotrimazole (CTR), econazole (ECO), fluconazole (FLU), flucytosine (FCT), fosfluconazole (FFL), griseofulvin (GRI), hachimycin (HCH), ibrexafungerp (IBX), isavuconazole (ISV), isoconazole (ISO), itraconazole (ITR), ketoconazole (KET), manogepix (MGX), micafungin (MIF), miconazole (MCZ), nystatin (NYS), oteseconazole (OTE), pimaricin (PMR), posaconazole (POS), rezafungin (RZF), ribociclib (RBC), sulconazole (SUC), terbinafine (TRB), terconazole (TRC), and voriconazole (VOR)
 \item \code{\link[=antimycobacterials]{antimycobacterials()}} can select: \cr 4-aminosalicylic acid (AMA), calcium aminosalicylate (CLA), capreomycin (CAP), clofazimine (CLF), delamanid (DLM), enviomycin (ENV), ethambutol (ETH), ethambutol/isoniazid (ETI), ethionamide (ETI1), isoniazid (INH), isoniazid/sulfamethoxazole/trimethoprim/pyridoxine (IST), morinamide (MRN), p-aminosalicylic acid (PAS), pretomanid (PMD), protionamide (PTH), pyrazinamide (PZA), rifabutin (RIB), rifampicin (RIF), rifampicin/ethambutol/isoniazid (REI), rifampicin/isoniazid (RFI), rifampicin/pyrazinamide/ethambutol/isoniazid (RPEI), rifampicin/pyrazinamide/isoniazid (RPI), rifamycin (RFM), rifapentine (RFP), simvastatin/fenofibrate (SMF), sodium aminosalicylate (SDA), streptomycin/isoniazid (STI), terizidone (TRZ), thioacetazone (TAT), thioacetazone/isoniazid (THI1), tiocarlide (TCR), and viomycin (VIO)
-\item \code{\link[=betalactams]{betalactams()}} can select: \cr amoxicillin (AMX), amoxicillin/clavulanic acid (AMC), amoxicillin/sulbactam (AXS), ampicillin (AMP), ampicillin/sulbactam (SAM), apalcillin (APL), aspoxicillin (APX), avibactam (AVB), azidocillin (AZD), azlocillin (AZL), aztreonam (ATM), aztreonam/avibactam (AZA), aztreonam/nacubactam (ANC), bacampicillin (BAM), benzathine benzylpenicillin (BNB), benzathine phenoxymethylpenicillin (BNP), benzylpenicillin (PEN), biapenem (BIA), carbenicillin (CRB), carindacillin (CRN), cefacetrile (CAC), cefaclor (CEC), cefadroxil (CFR), cefalexin (LEX), cefaloridine (RID), cefalotin (CEP), cefamandole (MAN), cefapirin (HAP), cefatrizine (CTZ), cefazedone (CZD), cefazolin (CZO), cefcapene (CCP), cefcapene pivoxil (CCX), cefdinir (CDR), cefditoren (DIT), cefditoren pivoxil (DIX), cefepime (FEP), cefepime/clavulanic acid (CPC), cefepime/nacubactam (FNC), cefepime/tazobactam (FPT), cefetamet (CAT), cefetamet pivoxil (CPI), cefetecol (CCL), cefetrizole (CZL), cefiderocol (FDC), cefixime (CFM), cefmenoxime (CMX), cefmetazole (CMZ), cefodizime (DIZ), cefonicid (CID), cefoperazone (CFP), cefoperazone/sulbactam (CSL), ceforanide (CND), cefoselis (CSE), cefotaxime (CTX), cefotaxime/clavulanic acid (CTC), cefotaxime/sulbactam (CTS), cefotetan (CTT), cefotiam (CTF), cefotiam hexetil (CHE), cefovecin (FOV), cefoxitin (FOX), cefoxitin screening (FOX1), cefozopran (ZOP), cefpimizole (CFZ), cefpiramide (CPM), cefpirome (CPO), cefpodoxime (CPD), cefpodoxime proxetil (CPX), cefpodoxime/clavulanic acid (CDC), cefprozil (CPR), cefquinome (CEQ), cefroxadine (CRD), cefsulodin (CFS), cefsumide (CSU), ceftaroline (CPT), ceftaroline/avibactam (CPA), ceftazidime (CAZ), ceftazidime/avibactam (CZA), ceftazidime/clavulanic acid (CCV), cefteram (CEM), cefteram pivoxil (CPL), ceftezole (CTL), ceftibuten (CTB), ceftiofur (TIO), ceftizoxime (CZX), ceftizoxime alapivoxil (CZP), ceftobiprole (BPR), ceftobiprole medocaril (CFM1), ceftolozane/tazobactam (CZT), ceftriaxone (CRO), ceftriaxone/beta-lactamase inhibitor (CEB), cefuroxime (CXM), cefuroxime axetil (CXA), cephradine (CED), ciclacillin (CIC), clometocillin (CLM), cloxacillin (CLO), dicloxacillin (DIC), doripenem (DOR), epicillin (EPC), ertapenem (ETP), flucloxacillin (FLC), hetacillin (HET), imipenem (IPM), imipenem/EDTA (IPE), imipenem/relebactam (IMR), latamoxef (LTM), lenampicillin (LEN), loracarbef (LOR), mecillinam (MEC), meropenem (MEM), meropenem/nacubactam (MNC), meropenem/vaborbactam (MEV), metampicillin (MTM), meticillin (MET), mezlocillin (MEZ), mezlocillin/sulbactam (MSU), nacubactam (NAC), nafcillin (NAF), oxacillin (OXA), panipenem (PAN), penamecillin (PNM), penicillin/novobiocin (PNO), penicillin/sulbactam (PSU), pheneticillin (PHE), phenoxymethylpenicillin (PHN), piperacillin (PIP), piperacillin/sulbactam (PIS), piperacillin/tazobactam (TZP), piridicillin (PRC), pivampicillin (PVM), pivmecillinam (PME), procaine benzylpenicillin (PRB), propicillin (PRP), razupenem (RZM), ritipenem (RIT), ritipenem acoxil (RIA), sarmoxicillin (SRX), sulbactam (SUL), sulbenicillin (SBC), sultamicillin (SLT6), talampicillin (TAL), tazobactam (TAZ), tebipenem (TBP), temocillin (TEM), ticarcillin (TIC), and ticarcillin/clavulanic acid (TCC)
+\item \code{\link[=betalactams]{betalactams()}} can select: \cr amoxicillin (AMX), amoxicillin/clavulanic acid (AMC), amoxicillin/sulbactam (AXS), ampicillin (AMP), ampicillin/sulbactam (SAM), apalcillin (APL), aspoxicillin (APX), azidocillin (AZD), azlocillin (AZL), aztreonam (ATM), aztreonam/avibactam (AZA), aztreonam/nacubactam (ANC), bacampicillin (BAM), benzathine benzylpenicillin (BNB), benzathine phenoxymethylpenicillin (BNP), benzylpenicillin (PEN), biapenem (BIA), carbenicillin (CRB), carindacillin (CRN), carumonam (CAR), cefacetrile (CAC), cefaclor (CEC), cefadroxil (CFR), cefalexin (LEX), cefaloridine (RID), cefalotin (CEP), cefamandole (MAN), cefapirin (HAP), cefatrizine (CTZ), cefazedone (CZD), cefazolin (CZO), cefcapene (CCP), cefcapene pivoxil (CCX), cefdinir (CDR), cefditoren (DIT), cefditoren pivoxil (DIX), cefepime (FEP), cefepime/amikacin (CFA), cefepime/clavulanic acid (CPC), cefepime/nacubactam (FNC), cefepime/tazobactam (FPT), cefepime/zidebactam (FPZ), cefetamet (CAT), cefetamet pivoxil (CPI), cefetecol (CCL), cefetrizole (CZL), cefiderocol (FDC), cefixime (CFM), cefmenoxime (CMX), cefmetazole (CMZ), cefodizime (DIZ), cefonicid (CID), cefoperazone (CFP), cefoperazone/sulbactam (CSL), ceforanide (CND), cefoselis (CSE), cefotaxime (CTX), cefotaxime/clavulanic acid (CTC), cefotaxime/sulbactam (CTS), cefotetan (CTT), cefotiam (CTF), cefotiam hexetil (CHE), cefovecin (FOV), cefoxitin (FOX), cefoxitin screening (FOX1), cefozopran (ZOP), cefpimizole (CFZ), cefpiramide (CPM), cefpirome (CPO), cefpodoxime (CPD), cefpodoxime proxetil (CPX), cefpodoxime/clavulanic acid (CDC), cefprozil (CPR), cefquinome (CEQ), cefroxadine (CRD), cefsulodin (CFS), cefsumide (CSU), ceftaroline (CPT), ceftaroline/avibactam (CPA), ceftazidime (CAZ), ceftazidime/avibactam (CZA), ceftazidime/clavulanic acid (CCV), cefteram (CEM), cefteram pivoxil (CPL), ceftezole (CTL), ceftibuten (CTB), ceftiofur (TIO), ceftizoxime (CZX), ceftizoxime alapivoxil (CZP), ceftobiprole (BPR), ceftobiprole medocaril (CFM1), ceftolozane/tazobactam (CZT), ceftriaxone (CRO), ceftriaxone/beta-lactamase inhibitor (CEB), cefuroxime (CXM), cefuroxime axetil (CXA), cephradine (CED), ciclacillin (CIC), clometocillin (CLM), cloxacillin (CLO), dicloxacillin (DIC), doripenem (DOR), epicillin (EPC), ertapenem (ETP), flucloxacillin (FLC), hetacillin (HET), imipenem (IPM), imipenem/EDTA (IPE), imipenem/relebactam (IMR), latamoxef (LTM), lenampicillin (LEN), loracarbef (LOR), mecillinam (MEC), meropenem (MEM), meropenem/nacubactam (MNC), meropenem/vaborbactam (MEV), metampicillin (MTM), meticillin (MET), mezlocillin (MEZ), mezlocillin/sulbactam (MSU), nafcillin (NAF), oxacillin (OXA), panipenem (PAN), penamecillin (PNM), penicillin/novobiocin (PNO), penicillin/sulbactam (PSU), pheneticillin (PHE), phenoxymethylpenicillin (PHN), piperacillin (PIP), piperacillin/sulbactam (PIS), piperacillin/tazobactam (TZP), piridicillin (PRC), pivampicillin (PVM), pivmecillinam (PME), procaine benzylpenicillin (PRB), propicillin (PRP), razupenem (RZM), ritipenem (RIT), ritipenem acoxil (RIA), sarmoxicillin (SRX), sulbenicillin (SBC), sultamicillin (SLT6), talampicillin (TAL), tebipenem (TBP), temocillin (TEM), ticarcillin (TIC), ticarcillin/clavulanic acid (TCC), and tigemonam (TMN)
-\item \code{\link[=betalactams_with_inhibitor]{betalactams_with_inhibitor()}} can select: \cr amoxicillin/clavulanic acid (AMC), amoxicillin/sulbactam (AXS), ampicillin/sulbactam (SAM), aztreonam/avibactam (AZA), aztreonam/nacubactam (ANC), cefepime/clavulanic acid (CPC), cefepime/nacubactam (FNC), cefepime/tazobactam (FPT), cefoperazone/sulbactam (CSL), cefotaxime/clavulanic acid (CTC), cefotaxime/sulbactam (CTS), cefpodoxime/clavulanic acid (CDC), ceftaroline/avibactam (CPA), ceftazidime/avibactam (CZA), ceftazidime/clavulanic acid (CCV), ceftolozane/tazobactam (CZT), ceftriaxone/beta-lactamase inhibitor (CEB), imipenem/relebactam (IMR), meropenem/nacubactam (MNC), meropenem/vaborbactam (MEV), mezlocillin/sulbactam (MSU), penicillin/novobiocin (PNO), penicillin/sulbactam (PSU), piperacillin/sulbactam (PIS), piperacillin/tazobactam (TZP), and ticarcillin/clavulanic acid (TCC)
+\item \code{\link[=betalactams_with_inhibitor]{betalactams_with_inhibitor()}} can select: \cr amoxicillin/clavulanic acid (AMC), amoxicillin/sulbactam (AXS), ampicillin/sulbactam (SAM), aztreonam/avibactam (AZA), aztreonam/nacubactam (ANC), cefepime/amikacin (CFA), cefepime/clavulanic acid (CPC), cefepime/nacubactam (FNC), cefepime/tazobactam (FPT), cefepime/zidebactam (FPZ), cefoperazone/sulbactam (CSL), cefotaxime/clavulanic acid (CTC), cefotaxime/sulbactam (CTS), cefpodoxime/clavulanic acid (CDC), ceftaroline/avibactam (CPA), ceftazidime/avibactam (CZA), ceftazidime/clavulanic acid (CCV), ceftolozane/tazobactam (CZT), ceftriaxone/beta-lactamase inhibitor (CEB), imipenem/relebactam (IMR), meropenem/nacubactam (MNC), meropenem/vaborbactam (MEV), mezlocillin/sulbactam (MSU), penicillin/novobiocin (PNO), penicillin/sulbactam (PSU), piperacillin/sulbactam (PIS), piperacillin/tazobactam (TZP), and ticarcillin/clavulanic acid (TCC)
 \item \code{\link[=carbapenems]{carbapenems()}} can select: \cr biapenem (BIA), doripenem (DOR), ertapenem (ETP), imipenem (IPM), imipenem/EDTA (IPE), imipenem/relebactam (IMR), meropenem (MEM), meropenem/nacubactam (MNC), meropenem/vaborbactam (MEV), panipenem (PAN), razupenem (RZM), ritipenem (RIT), ritipenem acoxil (RIA), and tebipenem (TBP)
-\item \code{\link[=cephalosporins]{cephalosporins()}} can select: \cr cefacetrile (CAC), cefaclor (CEC), cefadroxil (CFR), cefalexin (LEX), cefaloridine (RID), cefalotin (CEP), cefamandole (MAN), cefapirin (HAP), cefatrizine (CTZ), cefazedone (CZD), cefazolin (CZO), cefcapene (CCP), cefcapene pivoxil (CCX), cefdinir (CDR), cefditoren (DIT), cefditoren pivoxil (DIX), cefepime (FEP), cefepime/clavulanic acid (CPC), cefepime/tazobactam (FPT), cefetamet (CAT), cefetamet pivoxil (CPI), cefetecol (CCL), cefetrizole (CZL), cefiderocol (FDC), cefixime (CFM), cefmenoxime (CMX), cefmetazole (CMZ), cefodizime (DIZ), cefonicid (CID), cefoperazone (CFP), cefoperazone/sulbactam (CSL), ceforanide (CND), cefoselis (CSE), cefotaxime (CTX), cefotaxime/clavulanic acid (CTC), cefotaxime/sulbactam (CTS), cefotetan (CTT), cefotiam (CTF), cefotiam hexetil (CHE), cefovecin (FOV), cefoxitin (FOX), cefoxitin screening (FOX1), cefozopran (ZOP), cefpimizole (CFZ), cefpiramide (CPM), cefpirome (CPO), cefpodoxime (CPD), cefpodoxime proxetil (CPX), cefpodoxime/clavulanic acid (CDC), cefprozil (CPR), cefquinome (CEQ), cefroxadine (CRD), cefsulodin (CFS), cefsumide (CSU), ceftaroline (CPT), ceftaroline/avibactam (CPA), ceftazidime (CAZ), ceftazidime/avibactam (CZA), ceftazidime/clavulanic acid (CCV), cefteram (CEM), cefteram pivoxil (CPL), ceftezole (CTL), ceftibuten (CTB), ceftiofur (TIO), ceftizoxime (CZX), ceftizoxime alapivoxil (CZP), ceftobiprole (BPR), ceftobiprole medocaril (CFM1), ceftolozane/tazobactam (CZT), ceftriaxone (CRO), ceftriaxone/beta-lactamase inhibitor (CEB), cefuroxime (CXM), cefuroxime axetil (CXA), cephradine (CED), latamoxef (LTM), and loracarbef (LOR)
+\item \code{\link[=cephalosporins]{cephalosporins()}} can select: \cr cefacetrile (CAC), cefaclor (CEC), cefadroxil (CFR), cefalexin (LEX), cefaloridine (RID), cefalotin (CEP), cefamandole (MAN), cefapirin (HAP), cefatrizine (CTZ), cefazedone (CZD), cefazolin (CZO), cefcapene (CCP), cefcapene pivoxil (CCX), cefdinir (CDR), cefditoren (DIT), cefditoren pivoxil (DIX), cefepime (FEP), cefepime/amikacin (CFA), cefepime/clavulanic acid (CPC), cefepime/nacubactam (FNC), cefepime/tazobactam (FPT), cefepime/zidebactam (FPZ), cefetamet (CAT), cefetamet pivoxil (CPI), cefetecol (CCL), cefetrizole (CZL), cefiderocol (FDC), cefixime (CFM), cefmenoxime (CMX), cefmetazole (CMZ), cefodizime (DIZ), cefonicid (CID), cefoperazone (CFP), cefoperazone/sulbactam (CSL), ceforanide (CND), cefoselis (CSE), cefotaxime (CTX), cefotaxime/clavulanic acid (CTC), cefotaxime/sulbactam (CTS), cefotetan (CTT), cefotiam (CTF), cefotiam hexetil (CHE), cefovecin (FOV), cefoxitin (FOX), cefoxitin screening (FOX1), cefozopran (ZOP), cefpimizole (CFZ), cefpiramide (CPM), cefpirome (CPO), cefpodoxime (CPD), cefpodoxime proxetil (CPX), cefpodoxime/clavulanic acid (CDC), cefprozil (CPR), cefquinome (CEQ), cefroxadine (CRD), cefsulodin (CFS), cefsumide (CSU), ceftaroline (CPT), ceftaroline/avibactam (CPA), ceftazidime (CAZ), ceftazidime/avibactam (CZA), ceftazidime/clavulanic acid (CCV), cefteram (CEM), cefteram pivoxil (CPL), ceftezole (CTL), ceftibuten (CTB), ceftiofur (TIO), ceftizoxime (CZX), ceftizoxime alapivoxil (CZP), ceftobiprole (BPR), ceftobiprole medocaril (CFM1), ceftolozane/tazobactam (CZT), ceftriaxone (CRO), ceftriaxone/beta-lactamase inhibitor (CEB), cefuroxime (CXM), cefuroxime axetil (CXA), cephradine (CED), latamoxef (LTM), and loracarbef (LOR)
 \item \code{\link[=cephalosporins_1st]{cephalosporins_1st()}} can select: \cr cefacetrile (CAC), cefadroxil (CFR), cefalexin (LEX), cefaloridine (RID), cefalotin (CEP), cefapirin (HAP), cefatrizine (CTZ), cefazedone (CZD), cefazolin (CZO), cefroxadine (CRD), ceftezole (CTL), and cephradine (CED)
 \item \code{\link[=cephalosporins_2nd]{cephalosporins_2nd()}} can select: \cr cefaclor (CEC), cefamandole (MAN), cefmetazole (CMZ), cefonicid (CID), ceforanide (CND), cefotetan (CTT), cefotiam (CTF), cefoxitin (FOX), cefoxitin screening (FOX1), cefprozil (CPR), cefuroxime (CXM), cefuroxime axetil (CXA), and loracarbef (LOR)
 \item \code{\link[=cephalosporins_3rd]{cephalosporins_3rd()}} can select: \cr cefcapene (CCP), cefcapene pivoxil (CCX), cefdinir (CDR), cefditoren (DIT), cefditoren pivoxil (DIX), cefetamet (CAT), cefetamet pivoxil (CPI), cefixime (CFM), cefmenoxime (CMX), cefodizime (DIZ), cefoperazone (CFP), cefoperazone/sulbactam (CSL), cefotaxime (CTX), cefotaxime/clavulanic acid (CTC), cefotaxime/sulbactam (CTS), cefotiam hexetil (CHE), cefovecin (FOV), cefpimizole (CFZ), cefpiramide (CPM), cefpodoxime (CPD), cefpodoxime proxetil (CPX), cefpodoxime/clavulanic acid (CDC), cefsulodin (CFS), ceftazidime (CAZ), ceftazidime/avibactam (CZA), ceftazidime/clavulanic acid (CCV), cefteram (CEM), cefteram pivoxil (CPL), ceftibuten (CTB), ceftiofur (TIO), ceftizoxime (CZX), ceftizoxime alapivoxil (CZP), ceftriaxone (CRO), ceftriaxone/beta-lactamase inhibitor (CEB), and latamoxef (LTM)
-\item \code{\link[=cephalosporins_4th]{cephalosporins_4th()}} can select: \cr cefepime (FEP), cefepime/clavulanic acid (CPC), cefepime/tazobactam (FPT), cefetecol (CCL), cefoselis (CSE), cefozopran (ZOP), cefpirome (CPO), and cefquinome (CEQ)
+\item \code{\link[=cephalosporins_4th]{cephalosporins_4th()}} can select: \cr cefepime (FEP), cefepime/amikacin (CFA), cefepime/clavulanic acid (CPC), cefepime/nacubactam (FNC), cefepime/tazobactam (FPT), cefepime/zidebactam (FPZ), cefetecol (CCL), cefoselis (CSE), cefozopran (ZOP), cefpirome (CPO), and cefquinome (CEQ)
 \item \code{\link[=cephalosporins_5th]{cephalosporins_5th()}} can select: \cr ceftaroline (CPT), ceftaroline/avibactam (CPA), ceftobiprole (BPR), ceftobiprole medocaril (CFM1), and ceftolozane/tazobactam (CZT)
 \item \code{\link[=fluoroquinolones]{fluoroquinolones()}} can select: \cr besifloxacin (BES), ciprofloxacin (CIP), clinafloxacin (CLX), danofloxacin (DAN), delafloxacin (DFX), difloxacin (DIF), enoxacin (ENX), enrofloxacin (ENR), finafloxacin (FIN), fleroxacin (FLE), garenoxacin (GRN), gatifloxacin (GAT), gemifloxacin (GEM), grepafloxacin (GRX), lascufloxacin (LSC), levofloxacin (LVX), levonadifloxacin (LND), lomefloxacin (LOM), marbofloxacin (MAR), metioxate (MXT), miloxacin (MIL), moxifloxacin (MFX), nadifloxacin (NAD), nifuroquine (NIF), norfloxacin (NOR), ofloxacin (OFX), orbifloxacin (ORB), pazufloxacin (PAZ), pefloxacin (PEF), pradofloxacin (PRA), premafloxacin (PRX), prulifloxacin (PRU), rufloxacin (RFL), sarafloxacin (SAR), sitafloxacin (SIT), sparfloxacin (SPX), temafloxacin (TMX), tilbroquinol (TBQ), tioxacin (TXC), tosufloxacin (TFX), and trovafloxacin (TVA)
 \item \code{\link[=glycopeptides]{glycopeptides()}} can select: \cr avoparcin (AVO), dalbavancin (DAL), norvancomycin (NVA), oritavancin (ORI), ramoplanin (RAM), teicoplanin (TEC), teicoplanin-macromethod (TCM), telavancin (TLV), vancomycin (VAN), and vancomycin-macromethod (VAM)
-\item \code{\link[=lincosamides]{lincosamides()}} can select: \cr acetylmidecamycin (ACM), acetylspiramycin (ASP), clindamycin (CLI), clindamycin inducible screening (CLI1), gamithromycin (GAM), kitasamycin (KIT), lincomycin (LIN), meleumycin (MEL), nafithromycin (ZWK), pirlimycin (PRL), primycin (PRM), solithromycin (SOL), tildipirosin (TIP), tilmicosin (TIL), tulathromycin (TUL), tylosin (TYL), and tylvalosin (TYL1)
+\item \code{\link[=isoxazolylpenicillins]{isoxazolylpenicillins()}} can select: \cr cloxacillin (CLO), dicloxacillin (DIC), flucloxacillin (FLC), meticillin (MET), and oxacillin (OXA)
+\item \code{\link[=lincosamides]{lincosamides()}} can select: \cr clindamycin (CLI), lincomycin (LIN), and pirlimycin (PRL)
 \item \code{\link[=lipoglycopeptides]{lipoglycopeptides()}} can select: \cr dalbavancin (DAL), oritavancin (ORI), and telavancin (TLV)
-\item \code{\link[=macrolides]{macrolides()}} can select: \cr acetylmidecamycin (ACM), acetylspiramycin (ASP), azithromycin (AZM), clarithromycin (CLR), dirithromycin (DIR), erythromycin (ERY), flurithromycin (FLR1), gamithromycin (GAM), josamycin (JOS), kitasamycin (KIT), meleumycin (MEL), midecamycin (MID), miocamycin (MCM), nafithromycin (ZWK), oleandomycin (OLE), pirlimycin (PRL), primycin (PRM), rokitamycin (ROK), roxithromycin (RXT), solithromycin (SOL), spiramycin (SPI), telithromycin (TLT), tildipirosin (TIP), tilmicosin (TIL), troleandomycin (TRL), tulathromycin (TUL), tylosin (TYL), and tylvalosin (TYL1)
+\item \code{\link[=macrolides]{macrolides()}} can select: \cr acetylmidecamycin (ACM), acetylspiramycin (ASP), azithromycin (AZM), clarithromycin (CLR), dirithromycin (DIR), erythromycin (ERY), flurithromycin (FLR1), gamithromycin (GAM), josamycin (JOS), kitasamycin (KIT), meleumycin (MEL), midecamycin (MID), miocamycin (MCM), nafithromycin (ZWK), oleandomycin (OLE), rokitamycin (ROK), roxithromycin (RXT), solithromycin (SOL), spiramycin (SPI), telithromycin (TLT), tildipirosin (TIP), tilmicosin (TIL), troleandomycin (TRL), tulathromycin (TUL), tylosin (TYL), and tylvalosin (TYL1)
+\item \code{\link[=monobactams]{monobactams()}} can select: \cr aztreonam (ATM), aztreonam/avibactam (AZA), aztreonam/nacubactam (ANC), carumonam (CAR), and tigemonam (TMN)
 \item \code{\link[=nitrofurans]{nitrofurans()}} can select: \cr furazidin (FUR), furazolidone (FRZ), nifurtoinol (NFR), nitrofurantoin (NIT), and nitrofurazone (NIZ)
 \item \code{\link[=oxazolidinones]{oxazolidinones()}} can select: \cr cadazolid (CDZ), cycloserine (CYC), linezolid (LNZ), tedizolid (TZD), and thiacetazone (THA)
-\item \code{\link[=penicillins]{penicillins()}} can select: \cr amoxicillin (AMX), amoxicillin/clavulanic acid (AMC), amoxicillin/sulbactam (AXS), ampicillin (AMP), ampicillin/sulbactam (SAM), apalcillin (APL), aspoxicillin (APX), avibactam (AVB), azidocillin (AZD), azlocillin (AZL), aztreonam (ATM), aztreonam/avibactam (AZA), aztreonam/nacubactam (ANC), bacampicillin (BAM), benzathine benzylpenicillin (BNB), benzathine phenoxymethylpenicillin (BNP), benzylpenicillin (PEN), carbenicillin (CRB), carindacillin (CRN), cefepime/nacubactam (FNC), ciclacillin (CIC), clometocillin (CLM), cloxacillin (CLO), dicloxacillin (DIC), epicillin (EPC), flucloxacillin (FLC), hetacillin (HET), lenampicillin (LEN), mecillinam (MEC), metampicillin (MTM), meticillin (MET), mezlocillin (MEZ), mezlocillin/sulbactam (MSU), nacubactam (NAC), nafcillin (NAF), oxacillin (OXA), penamecillin (PNM), penicillin/novobiocin (PNO), penicillin/sulbactam (PSU), pheneticillin (PHE), phenoxymethylpenicillin (PHN), piperacillin (PIP), piperacillin/sulbactam (PIS), piperacillin/tazobactam (TZP), piridicillin (PRC), pivampicillin (PVM), pivmecillinam (PME), procaine benzylpenicillin (PRB), propicillin (PRP), sarmoxicillin (SRX), sulbactam (SUL), sulbenicillin (SBC), sultamicillin (SLT6), talampicillin (TAL), tazobactam (TAZ), temocillin (TEM), ticarcillin (TIC), and ticarcillin/clavulanic acid (TCC)
+\item \code{\link[=penicillins]{penicillins()}} can select: \cr amoxicillin (AMX), amoxicillin/clavulanic acid (AMC), amoxicillin/sulbactam (AXS), ampicillin (AMP), ampicillin/sulbactam (SAM), apalcillin (APL), aspoxicillin (APX), azidocillin (AZD), azlocillin (AZL), bacampicillin (BAM), benzathine benzylpenicillin (BNB), benzathine phenoxymethylpenicillin (BNP), benzylpenicillin (PEN), carbenicillin (CRB), carindacillin (CRN), ciclacillin (CIC), clometocillin (CLM), cloxacillin (CLO), dicloxacillin (DIC), epicillin (EPC), flucloxacillin (FLC), hetacillin (HET), lenampicillin (LEN), mecillinam (MEC), metampicillin (MTM), meticillin (MET), mezlocillin (MEZ), mezlocillin/sulbactam (MSU), nafcillin (NAF), oxacillin (OXA), penamecillin (PNM), penicillin/novobiocin (PNO), penicillin/sulbactam (PSU), pheneticillin (PHE), phenoxymethylpenicillin (PHN), piperacillin (PIP), piperacillin/sulbactam (PIS), piperacillin/tazobactam (TZP), piridicillin (PRC), pivampicillin (PVM), pivmecillinam (PME), procaine benzylpenicillin (PRB), propicillin (PRP), sarmoxicillin (SRX), sulbenicillin (SBC), sultamicillin (SLT6), talampicillin (TAL), temocillin (TEM), ticarcillin (TIC), and ticarcillin/clavulanic acid (TCC)
 \item \code{\link[=phenicols]{phenicols()}} can select: \cr chloramphenicol (CHL), florfenicol (FLR), and thiamphenicol (THI)
 \item \code{\link[=polymyxins]{polymyxins()}} can select: \cr colistin (COL), polymyxin B (PLB), and polymyxin B/polysorbate 80 (POP)
 \item \code{\link[=quinolones]{quinolones()}} can select: \cr besifloxacin (BES), cinoxacin (CIN), ciprofloxacin (CIP), ciprofloxacin/metronidazole (CIM), ciprofloxacin/ornidazole (CIO), ciprofloxacin/tinidazole (CIT), clinafloxacin (CLX), danofloxacin (DAN), delafloxacin (DFX), difloxacin (DIF), enoxacin (ENX), enrofloxacin (ENR), finafloxacin (FIN), fleroxacin (FLE), flumequine (FLM), garenoxacin (GRN), gatifloxacin (GAT), gemifloxacin (GEM), grepafloxacin (GRX), lascufloxacin (LSC), levofloxacin (LVX), levonadifloxacin (LND), lomefloxacin (LOM), marbofloxacin (MAR), metioxate (MXT), miloxacin (MIL), moxifloxacin (MFX), nadifloxacin (NAD), nalidixic acid (NAL), nemonoxacin (NEM), nifuroquine (NIF), nitroxoline (NTR), norfloxacin (NOR), ofloxacin (OFX), orbifloxacin (ORB), oxolinic acid (OXO), pazufloxacin (PAZ), pefloxacin (PEF), pipemidic acid (PPA), piromidic acid (PIR), pradofloxacin (PRA), premafloxacin (PRX), prulifloxacin (PRU), rosoxacin (ROS), rufloxacin (RFL), sarafloxacin (SAR), sitafloxacin (SIT), sparfloxacin (SPX), temafloxacin (TMX), tilbroquinol (TBQ), tioxacin (TXC), tosufloxacin (TFX), and trovafloxacin (TVA)

man/as.mo.Rd

@@ -160,7 +160,7 @@ This is based on:
 \item Vincent, R \emph{et al} (2013). \strong{MycoBank gearing up for new horizons.} IMA Fungus, 4(2), 371-9; \doi{10.5598/imafungus.2013.04.02.16}. Accessed from \url{https://www.mycobank.org} on June 24th, 2024.
 \item GBIF Secretariat (2023). GBIF Backbone Taxonomy. Checklist dataset \doi{10.15468/39omei}. Accessed from \url{https://www.gbif.org} on June 24th, 2024.
 \item Reimer, LC \emph{et al.} (2022). \strong{\emph{BacDive} in 2022: the knowledge base for standardized bacterial and archaeal data.} Nucleic Acids Res., 50(D1):D741-D74; \doi{10.1093/nar/gkab961}. Accessed from \url{https://bacdive.dsmz.de} on July 16th, 2024.
-\item Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microorganism', OID 2.16.840.1.114222.4.11.1009 (v12). URL: \url{https://www.cdc.gov/phin/php/phinvads}
+\item Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microorganism', OID 2.16.840.1.114222.4.11.1009 (v12). URL: \url{https://www.cdc.gov/phin/php/phinvads/}
 \item Bartlett A \emph{et al.} (2022). \strong{A comprehensive list of bacterial pathogens infecting humans} \emph{Microbiology} 168:001269; \doi{10.1099/mic.0.001269}
 }
 }

man/custom_eucast_rules.Rd

@@ -86,31 +86,33 @@ x
 #>      amoxicillin (AMX), ampicillin (AMP), azlocillin (AZL), mezlocillin (MEZ), piperacillin (PIP), piperacillin/tazobactam (TZP)
 }\if{html}{\out{</div>}}
 
-These 32 antibiotic groups are allowed in the rules (case-insensitive) and can be used in any combination:
+These 34 antibiotic groups are allowed in the rules (case-insensitive) and can be used in any combination:
 \itemize{
 \item aminoglycosides\cr(amikacin, amikacin/fosfomycin, apramycin, arbekacin, astromicin, bekanamycin, dibekacin, framycetin, gentamicin, gentamicin-high, habekacin, hygromycin, isepamicin, kanamycin, kanamycin-high, kanamycin/cephalexin, micronomicin, neomycin, netilmicin, pentisomicin, plazomicin, propikacin, ribostamycin, sisomicin, streptoduocin, streptomycin, streptomycin-high, tobramycin, and tobramycin-high)
 \item aminopenicillins\cr(amoxicillin and ampicillin)
 \item antifungals\cr(amorolfine, amphotericin B, amphotericin B-high, anidulafungin, butoconazole, caspofungin, ciclopirox, clotrimazole, econazole, fluconazole, flucytosine, fosfluconazole, griseofulvin, hachimycin, ibrexafungerp, isavuconazole, isoconazole, itraconazole, ketoconazole, manogepix, micafungin, miconazole, nystatin, oteseconazole, pimaricin, posaconazole, rezafungin, ribociclib, sulconazole, terbinafine, terconazole, and voriconazole)
 \item antimycobacterials\cr(4-aminosalicylic acid, calcium aminosalicylate, capreomycin, clofazimine, delamanid, enviomycin, ethambutol, ethambutol/isoniazid, ethionamide, isoniazid, isoniazid/sulfamethoxazole/trimethoprim/pyridoxine, morinamide, p-aminosalicylic acid, pretomanid, protionamide, pyrazinamide, rifabutin, rifampicin, rifampicin/ethambutol/isoniazid, rifampicin/isoniazid, rifampicin/pyrazinamide/ethambutol/isoniazid, rifampicin/pyrazinamide/isoniazid, rifamycin, rifapentine, simvastatin/fenofibrate, sodium aminosalicylate, streptomycin/isoniazid, terizidone, thioacetazone, thioacetazone/isoniazid, tiocarlide, and viomycin)
-\item betalactams\cr(amoxicillin, amoxicillin/clavulanic acid, amoxicillin/sulbactam, ampicillin, ampicillin/sulbactam, apalcillin, aspoxicillin, avibactam, azidocillin, azlocillin, aztreonam, aztreonam/avibactam, aztreonam/nacubactam, bacampicillin, benzathine benzylpenicillin, benzathine phenoxymethylpenicillin, benzylpenicillin, biapenem, carbenicillin, carindacillin, cefacetrile, cefaclor, cefadroxil, cefalexin, cefaloridine, cefalotin, cefamandole, cefapirin, cefatrizine, cefazedone, cefazolin, cefcapene, cefcapene pivoxil, cefdinir, cefditoren, cefditoren pivoxil, cefepime, cefepime/clavulanic acid, cefepime/nacubactam, cefepime/tazobactam, cefetamet, cefetamet pivoxil, cefetecol, cefetrizole, cefiderocol, cefixime, cefmenoxime, cefmetazole, cefodizime, cefonicid, cefoperazone, cefoperazone/sulbactam, ceforanide, cefoselis, cefotaxime, cefotaxime/clavulanic acid, cefotaxime/sulbactam, cefotetan, cefotiam, cefotiam hexetil, cefovecin, cefoxitin, cefoxitin screening, cefozopran, cefpimizole, cefpiramide, cefpirome, cefpodoxime, cefpodoxime proxetil, cefpodoxime/clavulanic acid, cefprozil, cefquinome, cefroxadine, cefsulodin, cefsumide, ceftaroline, ceftaroline/avibactam, ceftazidime, ceftazidime/avibactam, ceftazidime/clavulanic acid, cefteram, cefteram pivoxil, ceftezole, ceftibuten, ceftiofur, ceftizoxime, ceftizoxime alapivoxil, ceftobiprole, ceftobiprole medocaril, ceftolozane/tazobactam, ceftriaxone, ceftriaxone/beta-lactamase inhibitor, cefuroxime, cefuroxime axetil, cephradine, ciclacillin, clometocillin, cloxacillin, dicloxacillin, doripenem, epicillin, ertapenem, flucloxacillin, hetacillin, imipenem, imipenem/EDTA, imipenem/relebactam, latamoxef, lenampicillin, loracarbef, mecillinam, meropenem, meropenem/nacubactam, meropenem/vaborbactam, metampicillin, meticillin, mezlocillin, mezlocillin/sulbactam, nacubactam, nafcillin, oxacillin, panipenem, penamecillin, penicillin/novobiocin, penicillin/sulbactam, pheneticillin, phenoxymethylpenicillin, piperacillin, piperacillin/sulbactam, piperacillin/tazobactam, piridicillin, pivampicillin, pivmecillinam, procaine benzylpenicillin, propicillin, razupenem, ritipenem, ritipenem acoxil, sarmoxicillin, sulbactam, sulbenicillin, sultamicillin, talampicillin, tazobactam, tebipenem, temocillin, ticarcillin, and ticarcillin/clavulanic acid)
+\item betalactams\cr(amoxicillin, amoxicillin/clavulanic acid, amoxicillin/sulbactam, ampicillin, ampicillin/sulbactam, apalcillin, aspoxicillin, azidocillin, azlocillin, aztreonam, aztreonam/avibactam, aztreonam/nacubactam, bacampicillin, benzathine benzylpenicillin, benzathine phenoxymethylpenicillin, benzylpenicillin, biapenem, carbenicillin, carindacillin, carumonam, cefacetrile, cefaclor, cefadroxil, cefalexin, cefaloridine, cefalotin, cefamandole, cefapirin, cefatrizine, cefazedone, cefazolin, cefcapene, cefcapene pivoxil, cefdinir, cefditoren, cefditoren pivoxil, cefepime, cefepime/amikacin, cefepime/clavulanic acid, cefepime/nacubactam, cefepime/tazobactam, cefepime/zidebactam, cefetamet, cefetamet pivoxil, cefetecol, cefetrizole, cefiderocol, cefixime, cefmenoxime, cefmetazole, cefodizime, cefonicid, cefoperazone, cefoperazone/sulbactam, ceforanide, cefoselis, cefotaxime, cefotaxime/clavulanic acid, cefotaxime/sulbactam, cefotetan, cefotiam, cefotiam hexetil, cefovecin, cefoxitin, cefoxitin screening, cefozopran, cefpimizole, cefpiramide, cefpirome, cefpodoxime, cefpodoxime proxetil, cefpodoxime/clavulanic acid, cefprozil, cefquinome, cefroxadine, cefsulodin, cefsumide, ceftaroline, ceftaroline/avibactam, ceftazidime, ceftazidime/avibactam, ceftazidime/clavulanic acid, cefteram, cefteram pivoxil, ceftezole, ceftibuten, ceftiofur, ceftizoxime, ceftizoxime alapivoxil, ceftobiprole, ceftobiprole medocaril, ceftolozane/tazobactam, ceftriaxone, ceftriaxone/beta-lactamase inhibitor, cefuroxime, cefuroxime axetil, cephradine, ciclacillin, clometocillin, cloxacillin, dicloxacillin, doripenem, epicillin, ertapenem, flucloxacillin, hetacillin, imipenem, imipenem/EDTA, imipenem/relebactam, latamoxef, lenampicillin, loracarbef, mecillinam, meropenem, meropenem/nacubactam, meropenem/vaborbactam, metampicillin, meticillin, mezlocillin, mezlocillin/sulbactam, nafcillin, oxacillin, panipenem, penamecillin, penicillin/novobiocin, penicillin/sulbactam, pheneticillin, phenoxymethylpenicillin, piperacillin, piperacillin/sulbactam, piperacillin/tazobactam, piridicillin, pivampicillin, pivmecillinam, procaine benzylpenicillin, propicillin, razupenem, ritipenem, ritipenem acoxil, sarmoxicillin, sulbenicillin, sultamicillin, talampicillin, tebipenem, temocillin, ticarcillin, ticarcillin/clavulanic acid, and tigemonam)
-\item betalactams_with_inhibitor\cr(amoxicillin/clavulanic acid, amoxicillin/sulbactam, ampicillin/sulbactam, aztreonam/avibactam, aztreonam/nacubactam, cefepime/clavulanic acid, cefepime/nacubactam, cefepime/tazobactam, cefoperazone/sulbactam, cefotaxime/clavulanic acid, cefotaxime/sulbactam, cefpodoxime/clavulanic acid, ceftaroline/avibactam, ceftazidime/avibactam, ceftazidime/clavulanic acid, ceftolozane/tazobactam, ceftriaxone/beta-lactamase inhibitor, imipenem/relebactam, meropenem/nacubactam, meropenem/vaborbactam, mezlocillin/sulbactam, penicillin/novobiocin, penicillin/sulbactam, piperacillin/sulbactam, piperacillin/tazobactam, and ticarcillin/clavulanic acid)
+\item betalactams_with_inhibitor\cr(amoxicillin/clavulanic acid, amoxicillin/sulbactam, ampicillin/sulbactam, aztreonam/avibactam, aztreonam/nacubactam, cefepime/amikacin, cefepime/clavulanic acid, cefepime/nacubactam, cefepime/tazobactam, cefepime/zidebactam, cefoperazone/sulbactam, cefotaxime/clavulanic acid, cefotaxime/sulbactam, cefpodoxime/clavulanic acid, ceftaroline/avibactam, ceftazidime/avibactam, ceftazidime/clavulanic acid, ceftolozane/tazobactam, ceftriaxone/beta-lactamase inhibitor, imipenem/relebactam, meropenem/nacubactam, meropenem/vaborbactam, mezlocillin/sulbactam, penicillin/novobiocin, penicillin/sulbactam, piperacillin/sulbactam, piperacillin/tazobactam, and ticarcillin/clavulanic acid)
 \item carbapenems\cr(biapenem, doripenem, ertapenem, imipenem, imipenem/EDTA, imipenem/relebactam, meropenem, meropenem/nacubactam, meropenem/vaborbactam, panipenem, razupenem, ritipenem, ritipenem acoxil, and tebipenem)
-\item cephalosporins\cr(cefacetrile, cefaclor, cefadroxil, cefalexin, cefaloridine, cefalotin, cefamandole, cefapirin, cefatrizine, cefazedone, cefazolin, cefcapene, cefcapene pivoxil, cefdinir, cefditoren, cefditoren pivoxil, cefepime, cefepime/clavulanic acid, cefepime/tazobactam, cefetamet, cefetamet pivoxil, cefetecol, cefetrizole, cefiderocol, cefixime, cefmenoxime, cefmetazole, cefodizime, cefonicid, cefoperazone, cefoperazone/sulbactam, ceforanide, cefoselis, cefotaxime, cefotaxime/clavulanic acid, cefotaxime/sulbactam, cefotetan, cefotiam, cefotiam hexetil, cefovecin, cefoxitin, cefoxitin screening, cefozopran, cefpimizole, cefpiramide, cefpirome, cefpodoxime, cefpodoxime proxetil, cefpodoxime/clavulanic acid, cefprozil, cefquinome, cefroxadine, cefsulodin, cefsumide, ceftaroline, ceftaroline/avibactam, ceftazidime, ceftazidime/avibactam, ceftazidime/clavulanic acid, cefteram, cefteram pivoxil, ceftezole, ceftibuten, ceftiofur, ceftizoxime, ceftizoxime alapivoxil, ceftobiprole, ceftobiprole medocaril, ceftolozane/tazobactam, ceftriaxone, ceftriaxone/beta-lactamase inhibitor, cefuroxime, cefuroxime axetil, cephradine, latamoxef, and loracarbef)
+\item cephalosporins\cr(cefacetrile, cefaclor, cefadroxil, cefalexin, cefaloridine, cefalotin, cefamandole, cefapirin, cefatrizine, cefazedone, cefazolin, cefcapene, cefcapene pivoxil, cefdinir, cefditoren, cefditoren pivoxil, cefepime, cefepime/amikacin, cefepime/clavulanic acid, cefepime/nacubactam, cefepime/tazobactam, cefepime/zidebactam, cefetamet, cefetamet pivoxil, cefetecol, cefetrizole, cefiderocol, cefixime, cefmenoxime, cefmetazole, cefodizime, cefonicid, cefoperazone, cefoperazone/sulbactam, ceforanide, cefoselis, cefotaxime, cefotaxime/clavulanic acid, cefotaxime/sulbactam, cefotetan, cefotiam, cefotiam hexetil, cefovecin, cefoxitin, cefoxitin screening, cefozopran, cefpimizole, cefpiramide, cefpirome, cefpodoxime, cefpodoxime proxetil, cefpodoxime/clavulanic acid, cefprozil, cefquinome, cefroxadine, cefsulodin, cefsumide, ceftaroline, ceftaroline/avibactam, ceftazidime, ceftazidime/avibactam, ceftazidime/clavulanic acid, cefteram, cefteram pivoxil, ceftezole, ceftibuten, ceftiofur, ceftizoxime, ceftizoxime alapivoxil, ceftobiprole, ceftobiprole medocaril, ceftolozane/tazobactam, ceftriaxone, ceftriaxone/beta-lactamase inhibitor, cefuroxime, cefuroxime axetil, cephradine, latamoxef, and loracarbef)
 \item cephalosporins_1st\cr(cefacetrile, cefadroxil, cefalexin, cefaloridine, cefalotin, cefapirin, cefatrizine, cefazedone, cefazolin, cefroxadine, ceftezole, and cephradine)
 \item cephalosporins_2nd\cr(cefaclor, cefamandole, cefmetazole, cefonicid, ceforanide, cefotetan, cefotiam, cefoxitin, cefoxitin screening, cefprozil, cefuroxime, cefuroxime axetil, and loracarbef)
 \item cephalosporins_3rd\cr(cefcapene, cefcapene pivoxil, cefdinir, cefditoren, cefditoren pivoxil, cefetamet, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoperazone, cefoperazone/sulbactam, cefotaxime, cefotaxime/clavulanic acid, cefotaxime/sulbactam, cefotiam hexetil, cefovecin, cefpimizole, cefpiramide, cefpodoxime, cefpodoxime proxetil, cefpodoxime/clavulanic acid, cefsulodin, ceftazidime, ceftazidime/avibactam, ceftazidime/clavulanic acid, cefteram, cefteram pivoxil, ceftibuten, ceftiofur, ceftizoxime, ceftizoxime alapivoxil, ceftriaxone, ceftriaxone/beta-lactamase inhibitor, and latamoxef)
-\item cephalosporins_4th\cr(cefepime, cefepime/clavulanic acid, cefepime/tazobactam, cefetecol, cefoselis, cefozopran, cefpirome, and cefquinome)
+\item cephalosporins_4th\cr(cefepime, cefepime/amikacin, cefepime/clavulanic acid, cefepime/nacubactam, cefepime/tazobactam, cefepime/zidebactam, cefetecol, cefoselis, cefozopran, cefpirome, and cefquinome)
 \item cephalosporins_5th\cr(ceftaroline, ceftaroline/avibactam, ceftobiprole, ceftobiprole medocaril, and ceftolozane/tazobactam)
-\item cephalosporins_except_caz\cr(cefacetrile, cefaclor, cefadroxil, cefalexin, cefaloridine, cefalotin, cefamandole, cefapirin, cefatrizine, cefazedone, cefazolin, cefcapene, cefcapene pivoxil, cefdinir, cefditoren, cefditoren pivoxil, cefepime, cefepime/clavulanic acid, cefepime/tazobactam, cefetamet, cefetamet pivoxil, cefetecol, cefetrizole, cefiderocol, cefixime, cefmenoxime, cefmetazole, cefodizime, cefonicid, cefoperazone, cefoperazone/sulbactam, ceforanide, cefoselis, cefotaxime, cefotaxime/clavulanic acid, cefotaxime/sulbactam, cefotetan, cefotiam, cefotiam hexetil, cefovecin, cefoxitin, cefoxitin screening, cefozopran, cefpimizole, cefpiramide, cefpirome, cefpodoxime, cefpodoxime proxetil, cefpodoxime/clavulanic acid, cefprozil, cefquinome, cefroxadine, cefsulodin, cefsumide, ceftaroline, ceftaroline/avibactam, ceftazidime/avibactam, ceftazidime/clavulanic acid, cefteram, cefteram pivoxil, ceftezole, ceftibuten, ceftiofur, ceftizoxime, ceftizoxime alapivoxil, ceftobiprole, ceftobiprole medocaril, ceftolozane/tazobactam, ceftriaxone, ceftriaxone/beta-lactamase inhibitor, cefuroxime, cefuroxime axetil, cephradine, latamoxef, and loracarbef)
+\item cephalosporins_except_caz\cr(cefacetrile, cefaclor, cefadroxil, cefalexin, cefaloridine, cefalotin, cefamandole, cefapirin, cefatrizine, cefazedone, cefazolin, cefcapene, cefcapene pivoxil, cefdinir, cefditoren, cefditoren pivoxil, cefepime, cefepime/amikacin, cefepime/clavulanic acid, cefepime/nacubactam, cefepime/tazobactam, cefepime/zidebactam, cefetamet, cefetamet pivoxil, cefetecol, cefetrizole, cefiderocol, cefixime, cefmenoxime, cefmetazole, cefodizime, cefonicid, cefoperazone, cefoperazone/sulbactam, ceforanide, cefoselis, cefotaxime, cefotaxime/clavulanic acid, cefotaxime/sulbactam, cefotetan, cefotiam, cefotiam hexetil, cefovecin, cefoxitin, cefoxitin screening, cefozopran, cefpimizole, cefpiramide, cefpirome, cefpodoxime, cefpodoxime proxetil, cefpodoxime/clavulanic acid, cefprozil, cefquinome, cefroxadine, cefsulodin, cefsumide, ceftaroline, ceftaroline/avibactam, ceftazidime/avibactam, ceftazidime/clavulanic acid, cefteram, cefteram pivoxil, ceftezole, ceftibuten, ceftiofur, ceftizoxime, ceftizoxime alapivoxil, ceftobiprole, ceftobiprole medocaril, ceftolozane/tazobactam, ceftriaxone, ceftriaxone/beta-lactamase inhibitor, cefuroxime, cefuroxime axetil, cephradine, latamoxef, and loracarbef)
 \item fluoroquinolones\cr(besifloxacin, ciprofloxacin, clinafloxacin, danofloxacin, delafloxacin, difloxacin, enoxacin, enrofloxacin, finafloxacin, fleroxacin, garenoxacin, gatifloxacin, gemifloxacin, grepafloxacin, lascufloxacin, levofloxacin, levonadifloxacin, lomefloxacin, marbofloxacin, metioxate, miloxacin, moxifloxacin, nadifloxacin, nifuroquine, norfloxacin, ofloxacin, orbifloxacin, pazufloxacin, pefloxacin, pradofloxacin, premafloxacin, prulifloxacin, rufloxacin, sarafloxacin, sitafloxacin, sparfloxacin, temafloxacin, tilbroquinol, tioxacin, tosufloxacin, and trovafloxacin)
 \item glycopeptides\cr(avoparcin, dalbavancin, norvancomycin, oritavancin, ramoplanin, teicoplanin, teicoplanin-macromethod, telavancin, vancomycin, and vancomycin-macromethod)
 \item glycopeptides_except_lipo\cr(avoparcin, norvancomycin, ramoplanin, teicoplanin, teicoplanin-macromethod, vancomycin, and vancomycin-macromethod)
-\item lincosamides\cr(acetylmidecamycin, acetylspiramycin, clindamycin, clindamycin inducible screening, gamithromycin, kitasamycin, lincomycin, meleumycin, nafithromycin, pirlimycin, primycin, solithromycin, tildipirosin, tilmicosin, tulathromycin, tylosin, and tylvalosin)
+\item isoxazolylpenicillins\cr(cloxacillin, dicloxacillin, flucloxacillin, meticillin, and oxacillin)
+\item lincosamides\cr(clindamycin, lincomycin, and pirlimycin)
 \item lipoglycopeptides\cr(dalbavancin, oritavancin, and telavancin)
-\item macrolides\cr(acetylmidecamycin, acetylspiramycin, azithromycin, clarithromycin, dirithromycin, erythromycin, flurithromycin, gamithromycin, josamycin, kitasamycin, meleumycin, midecamycin, miocamycin, nafithromycin, oleandomycin, pirlimycin, primycin, rokitamycin, roxithromycin, solithromycin, spiramycin, telithromycin, tildipirosin, tilmicosin, troleandomycin, tulathromycin, tylosin, and tylvalosin)
+\item macrolides\cr(acetylmidecamycin, acetylspiramycin, azithromycin, clarithromycin, dirithromycin, erythromycin, flurithromycin, gamithromycin, josamycin, kitasamycin, meleumycin, midecamycin, miocamycin, nafithromycin, oleandomycin, rokitamycin, roxithromycin, solithromycin, spiramycin, telithromycin, tildipirosin, tilmicosin, troleandomycin, tulathromycin, tylosin, and tylvalosin)
+\item monobactams\cr(aztreonam, aztreonam/avibactam, aztreonam/nacubactam, carumonam, and tigemonam)
 \item nitrofurans\cr(furazidin, furazolidone, nifurtoinol, nitrofurantoin, and nitrofurazone)
 \item oxazolidinones\cr(cadazolid, cycloserine, linezolid, tedizolid, and thiacetazone)
-\item penicillins\cr(amoxicillin, amoxicillin/clavulanic acid, amoxicillin/sulbactam, ampicillin, ampicillin/sulbactam, apalcillin, aspoxicillin, avibactam, azidocillin, azlocillin, aztreonam, aztreonam/avibactam, aztreonam/nacubactam, bacampicillin, benzathine benzylpenicillin, benzathine phenoxymethylpenicillin, benzylpenicillin, carbenicillin, carindacillin, cefepime/nacubactam, ciclacillin, clometocillin, cloxacillin, dicloxacillin, epicillin, flucloxacillin, hetacillin, lenampicillin, mecillinam, metampicillin, meticillin, mezlocillin, mezlocillin/sulbactam, nacubactam, nafcillin, oxacillin, penamecillin, penicillin/novobiocin, penicillin/sulbactam, pheneticillin, phenoxymethylpenicillin, piperacillin, piperacillin/sulbactam, piperacillin/tazobactam, piridicillin, pivampicillin, pivmecillinam, procaine benzylpenicillin, propicillin, sarmoxicillin, sulbactam, sulbenicillin, sultamicillin, talampicillin, tazobactam, temocillin, ticarcillin, and ticarcillin/clavulanic acid)
+\item penicillins\cr(amoxicillin, amoxicillin/clavulanic acid, amoxicillin/sulbactam, ampicillin, ampicillin/sulbactam, apalcillin, aspoxicillin, azidocillin, azlocillin, bacampicillin, benzathine benzylpenicillin, benzathine phenoxymethylpenicillin, benzylpenicillin, carbenicillin, carindacillin, ciclacillin, clometocillin, cloxacillin, dicloxacillin, epicillin, flucloxacillin, hetacillin, lenampicillin, mecillinam, metampicillin, meticillin, mezlocillin, mezlocillin/sulbactam, nafcillin, oxacillin, penamecillin, penicillin/novobiocin, penicillin/sulbactam, pheneticillin, phenoxymethylpenicillin, piperacillin, piperacillin/sulbactam, piperacillin/tazobactam, piridicillin, pivampicillin, pivmecillinam, procaine benzylpenicillin, propicillin, sarmoxicillin, sulbenicillin, sultamicillin, talampicillin, temocillin, ticarcillin, and ticarcillin/clavulanic acid)
 \item phenicols\cr(chloramphenicol, florfenicol, and thiamphenicol)
 \item polymyxins\cr(colistin, polymyxin B, and polymyxin B/polysorbate 80)
 \item quinolones\cr(besifloxacin, cinoxacin, ciprofloxacin, ciprofloxacin/metronidazole, ciprofloxacin/ornidazole, ciprofloxacin/tinidazole, clinafloxacin, danofloxacin, delafloxacin, difloxacin, enoxacin, enrofloxacin, finafloxacin, fleroxacin, flumequine, garenoxacin, gatifloxacin, gemifloxacin, grepafloxacin, lascufloxacin, levofloxacin, levonadifloxacin, lomefloxacin, marbofloxacin, metioxate, miloxacin, moxifloxacin, nadifloxacin, nalidixic acid, nemonoxacin, nifuroquine, nitroxoline, norfloxacin, ofloxacin, orbifloxacin, oxolinic acid, pazufloxacin, pefloxacin, pipemidic acid, piromidic acid, pradofloxacin, premafloxacin, prulifloxacin, rosoxacin, rufloxacin, sarafloxacin, sitafloxacin, sparfloxacin, temafloxacin, tilbroquinol, tioxacin, tosufloxacin, and trovafloxacin)

man/first_isolate.Rd

@@ -5,7 +5,7 @@
 \alias{filter_first_isolate}
 \title{Determine First Isolates}
 \source{
-Methodology of this function is strictly based on:
+Methodology of these functions is strictly based on:
 \itemize{
 \item \strong{M39 Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data, 5th Edition}, 2022, \emph{Clinical and Laboratory Standards Institute (CLSI)}. \url{https://clsi.org/standards/products/microbiology/documents/m39/}.
 \item Hindler JF and Stelling J (2007). \strong{Analysis and Presentation of Cumulative Antibiograms: A New Consensus Guideline from the Clinical and Laboratory Standards Institute.} Clinical Infectious Diseases, 44(6), 867-873. \doi{10.1086/511864}
@@ -73,7 +73,8 @@ A \link{logical} vector
 Determine first isolates of all microorganisms of every patient per episode and (if needed) per specimen type. These functions support all four methods as summarised by Hindler \emph{et al.} in 2007 (\doi{10.1086/511864}). To determine patient episodes not necessarily based on microorganisms, use \code{\link[=is_new_episode]{is_new_episode()}} that also supports grouping with the \code{dplyr} package.
 }
 \details{
-The methodology implemented in these functions is based on the research overview by Hindler \emph{et al.} (2007, \doi{10.1086/511864}) and the recommendations outlined in the \href{https://clsi.org/standards/products/microbiology/documents/m39}{CLSI Guideline M39}.
+The methodology implemented in these functions is strictly based on the recommendations outlined in \href{https://clsi.org/standards/products/microbiology/documents/m39}{CLSI Guideline M39} and the research overview by Hindler \emph{et al.} (2007, \doi{10.1086/511864}).
+
 To conduct epidemiological analyses on antimicrobial resistance data, only so-called first isolates should be included to prevent overestimation and underestimation of antimicrobial resistance. Different methods can be used to do so, see below.
 
 These functions are context-aware. This means that the \code{x} argument can be left blank if used inside a \link{data.frame} call, see \emph{Examples}.

man/microorganisms.Rd

@@ -44,7 +44,7 @@ Furthermore, these sources were used for additional details:
 \item BacDive:\cr\cr
 Reimer, LC \emph{et al.} (2022). \strong{\emph{BacDive} in 2022: the knowledge base for standardized bacterial and archaeal data.} Nucleic Acids Res., 50(D1):D741-D74; \doi{10.1093/nar/gkab961}. Accessed from \url{https://bacdive.dsmz.de} on July 16th, 2024.
 \item Systematized Nomenclature of Medicine - Clinical Terms (SNOMED-CT):\cr\cr
-Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microorganism', OID 2.16.840.1.114222.4.11.1009 (v12). Accessed from \url{https://www.cdc.gov/phin/php/phinvads} on July 16th, 2024.
+Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microorganism', OID 2.16.840.1.114222.4.11.1009 (v12). Accessed from \url{https://www.cdc.gov/phin/php/phinvads/} on July 16th, 2024.
 \item Grimont \emph{et al.} (2007). Antigenic Formulae of the Salmonella Serovars, 9th Edition. WHO Collaborating Centre for Reference and Research on \emph{Salmonella} (WHOCC-SALM).
 \item Bartlett \emph{et al.} (2022). \strong{A comprehensive list of bacterial pathogens infecting humans} \emph{Microbiology} 168:001269; \doi{10.1099/mic.0.001269}
 }

man/mo_property.Rd

@@ -222,7 +222,7 @@ This function uses \code{\link[=as.mo]{as.mo()}} internally, which uses an advan
 \item Vincent, R \emph{et al} (2013). \strong{MycoBank gearing up for new horizons.} IMA Fungus, 4(2), 371-9; \doi{10.5598/imafungus.2013.04.02.16}. Accessed from \url{https://www.mycobank.org} on June 24th, 2024.
 \item GBIF Secretariat (2023). GBIF Backbone Taxonomy. Checklist dataset \doi{10.15468/39omei}. Accessed from \url{https://www.gbif.org} on June 24th, 2024.
 \item Reimer, LC \emph{et al.} (2022). \strong{\emph{BacDive} in 2022: the knowledge base for standardized bacterial and archaeal data.} Nucleic Acids Res., 50(D1):D741-D74; \doi{10.1093/nar/gkab961}. Accessed from \url{https://bacdive.dsmz.de} on July 16th, 2024.
-\item Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microorganism', OID 2.16.840.1.114222.4.11.1009 (v12). URL: \url{https://www.cdc.gov/phin/php/phinvads}
+\item Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microorganism', OID 2.16.840.1.114222.4.11.1009 (v12). URL: \url{https://www.cdc.gov/phin/php/phinvads/}
 \item Bartlett A \emph{et al.} (2022). \strong{A comprehensive list of bacterial pathogens infecting humans} \emph{Microbiology} 168:001269; \doi{10.1099/mic.0.001269}
 }
 }

tests/testthat/test-amr_selectors.R

@@ -42,9 +42,11 @@ expect_equal(ncol(example_isolates[, cephalosporins_4th(), drop = FALSE]), 1, to
 expect_equal(ncol(example_isolates[, cephalosporins_5th(), drop = FALSE]), 0, tolerance = 0.5)
 expect_equal(ncol(example_isolates[, fluoroquinolones(), drop = FALSE]), 2, tolerance = 0.5)
 expect_equal(ncol(example_isolates[, glycopeptides(), drop = FALSE]), 2, tolerance = 0.5)
+expect_equal(ncol(example_isolates[, isoxazolylpenicillins(), drop = FALSE]), 2, tolerance = 0.5)
 expect_equal(ncol(example_isolates[, lincosamides(), drop = FALSE]), 1, tolerance = 0.5)
 expect_equal(ncol(example_isolates[, lipoglycopeptides(), drop = FALSE]), 0, tolerance = 0.5)
 expect_equal(ncol(example_isolates[, macrolides(), drop = FALSE]), 2, tolerance = 0.5)
+expect_equal(ncol(example_isolates[, monobactams(), drop = FALSE]), 0, tolerance = 0.5)
 expect_equal(ncol(example_isolates[, nitrofurans(), drop = FALSE]), 1, tolerance = 0.5)
 expect_equal(ncol(example_isolates[, oxazolidinones(), drop = FALSE]), 1, tolerance = 0.5)
 expect_equal(ncol(example_isolates[, penicillins(), drop = FALSE]), 7, tolerance = 0.5)

tests/testthat/test-zzz.R

@@ -141,11 +141,8 @@ call_functions <- c(
 
 import_functions <- c(import_functions, call_functions)
 
-suggests <- tryCatch(strsplit(utils::packageDescription(pkg = ".", lib.loc = ".", fields = "Suggests"), "[,\n ]+")[[1]],
+suggests <- tryCatch(strsplit(pkgload::pkg_desc()$get_field("Suggests"), "[,\n ]+")[[1]],
-                     error = function(e) {
+                     error = function(e) unname(import_functions))
-                       print(list.files())
-                       return(import_functions)
-                     })
 for (i in seq_len(length(import_functions))) {
   fn <- names(import_functions)[i]
   pkg <- unname(import_functions[i])