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new website, freq updates

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dr. M.S. (Matthijs) Berends
2018-12-29 22:24:19 +01:00
parent fca6df9d3c
commit 92a32b62a7
153 changed files with 12867 additions and 69654 deletions
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20
.Rbuildignore
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@@ -1,11 +1,17 @@
^Meta$
^doc$
^CRAN-RELEASE$
^.*\.Rproj$
^\.Rproj\.user$
.travis.yml
appveyor.yml
.gitlab-ci.yml
.zenodo.json
_noinclude
^\.travis.yml$
^appveyor.yml$
^\.gitlab-ci.yml$
^\.zenodo.json$
^_noinclude$
^cran-comments\.md$
git.sh
public
^git.sh$
^public$
^docs$
^_pkgdown\.yml$
^pkgdown$
^index\.md$

3
.gitignore vendored
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@@ -1,3 +1,5 @@
Meta
doc
.Rproj.user
.Rhistory
.RData
@@ -13,6 +15,5 @@ _noinclude
*.dll
vignettes/*.R
.DS_Store
^cran-comments\.md$
^CRAN-RELEASE$
git.sh

3
.gitlab-ci.yml
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@@ -38,7 +38,8 @@ pages:
- Rscript -e "install.packages(c('pkgdown', 'devtools'), repos = 'https://cran.rstudio.com')"
- Rscript -e "devtools::install_dev_deps(repos = 'https://cran.rstudio.com')"
- Rscript -e "devtools::install(build = TRUE, upgrade = FALSE)"
- R -e "pkgdown::build_site()"
# - R -e "pkgdown::build_favicon()"
- R -e "pkgdown::build_site(examples = FALSE)"
artifacts:
paths:
- public

12
DESCRIPTION
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@@ -1,6 +1,6 @@
Package: AMR
Version: 0.5.0.9007
Date: 2018-12-22
Version: 0.5.0.9008
Date: 2018-12-29
Title: Antimicrobial Resistance Analysis
Authors@R: c(
person(
@@ -24,19 +24,19 @@ Authors@R: c(
given = "Corinna",
family = "Glasner",
email = "c.glasner@umcg.nl",
role = "ths",
role = c("aut", "ths"),
comment = c(ORCID = "0000-0003-1241-1328")),
person(
given = c("Alex", "W."),
family = "Friedrich",
email = "alex.friedrich@umcg.nl",
role = "ths",
role = c("aut", "ths"),
comment = c(ORCID = "0000-0003-4881-038X")),
person(
given = c("Bhanu", "N.", "M."),
family = "Sinha",
email = "b.sinha@umcg.nl",
role = "ths",
role = c("aut", "ths"),
comment = c(ORCID = "0000-0003-1634-0010")))
Description: Functions to simplify the analysis and prediction of Antimicrobial
Resistance (AMR) and to work with microbial and antimicrobial properties by
@@ -62,7 +62,7 @@ Suggests:
rstudioapi,
testthat (>= 1.0.2)
VignetteBuilder: knitr
URL: https://gitlab.com/msberends/AMR
URL: https://msberends.gitlab.io/AMR, https://gitlab.com/msberends/AMR
BugReports: https://gitlab.com/msberends/AMR/issues
License: GPL-2 | file LICENSE
Encoding: UTF-8

5
NAMESPACE
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@@ -11,6 +11,8 @@ S3method(as_tibble,frequency_tbl)
S3method(barplot,mic)
S3method(barplot,rsi)
S3method(diff,frequency_tbl)
S3method(droplevels,mic)
S3method(droplevels,rsi)
S3method(format,frequency_tbl)
S3method(hist,frequency_tbl)
S3method(kurtosis,data.frame)
@@ -76,6 +78,7 @@ export(get_locale)
export(ggplot_rsi)
export(guess_atc)
export(guess_mo)
export(header)
export(inner_join_microorganisms)
export(interpretive_reading)
export(is.atc)
@@ -143,6 +146,8 @@ exportMethods(as_tibble.frequency_tbl)
exportMethods(barplot.mic)
exportMethods(barplot.rsi)
exportMethods(diff.frequency_tbl)
exportMethods(droplevels.mic)
exportMethods(droplevels.rsi)
exportMethods(format.frequency_tbl)
exportMethods(hist.frequency_tbl)
exportMethods(kurtosis)

33
NEWS.md
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@@ -1,8 +1,11 @@
# 0.5.0.90xx (latest development version)
# AMR 0.5.0.90xx
**Note: this is the development version, which will eventually be released as AMR 0.6.0.**
#### New
* **BREAKING**: removed deprecated functions, parameters and references to 'bactid'. Use `as.mo` to identify an MO code.
* Support for `dplyr` version 0.8.0
* New website: https://msberends.gitlab.io/AMR (built with the great [`pkgdown`](https://pkgdown.r-lib.org/))
* Contains the complete manual of this package and all of its functions with an explanation of their parameters
* Support for [`dplyr`](https://dplyr.tidyverse.org) version 0.8.0
* Function `mo_failures` to review values that could not be coerced to a valid MO code, using `as.mo`. This latter function will now only show a maximum of 25 uncoerced values.
* Function `mo_renamed` to get a list of all returned values from `as.mo` that have had taxonomic renaming
* Function `age` to calculate the (patients) age in years
@@ -13,7 +16,7 @@
# or
filter_first_isolate(septic_patients)
```
is the same as:
is equal to:
```r
septic_patients %>%
mutate(only_firsts = first_isolate(septic_patients, ...)) %>%
@@ -42,21 +45,22 @@
* Summaries of class `mo` will now return the top 3 and the unique count, e.g. using `summary(mo)`
* Small text updates to summaries of class `rsi` and `mic`
* Frequency tables (`freq` function):
* Header info is now available as a list, with the `header` function
* Added header info for class `mo` to show unique count of families, genera and species
* Now honours the `decimal.mark` setting, which just like `format` defaults to `getOption("OutDec")`
* The new `big.mark` parameter will at default be `","` when `decimal.mark = "."` and `"."` otherwise
* Fix for header text where all observations are `NA`
* New parameter `droplevels` to exclude empty factor levels when input is a factor
* Factor levels will be in header when present
* Function `scale_y_percent` now has the `limits` parameter
* Factor levels will be in header when present in input data
* Function `scale_y_percent` now contains the `limits` parameter
* Automatic parameter filling for `mdro`, `key_antibiotics` and `eucast_rules`
* Updated examples for resistance prediction (`resistance_predict` function)
* Fix for `as.mic` to support more values ending in (several) zeroes
#### Other
* Updated licence text to emphasise GPL 2.0 and that this is an R package.
# 0.5.0 (latest stable release)
**Published on CRAN: 2018-11-30**
# AMR 0.5.0
#### New
* Repository moved to GitLab: https://gitlab.com/msberends/AMR
@@ -139,8 +143,7 @@
* Updated vignettes to comply with README
# 0.4.0
**Published on CRAN: 2018-10-01**
# AMR 0.4.0
#### New
* The data set `microorganisms` now contains **all microbial taxonomic data from ITIS** (kingdoms Bacteria, Fungi and Protozoa), the Integrated Taxonomy Information System, available via https://itis.gov. The data set now contains more than 18,000 microorganisms with all known bacteria, fungi and protozoa according ITIS with genus, species, subspecies, family, order, class, phylum and subkingdom. The new data set `microorganisms.old` contains all previously known taxonomic names from those kingdoms.
@@ -251,8 +254,7 @@
#### Other
* More unit tests to ensure better integrity of functions
# 0.3.0
**Published on CRAN: 2018-08-14**
# AMR 0.3.0
#### New
* **BREAKING**: `rsi_df` was removed in favour of new functions `portion_R`, `portion_IR`, `portion_I`, `portion_SI` and `portion_S` to selectively calculate resistance or susceptibility. These functions are 20 to 30 times faster than the old `rsi` function. The old function still works, but is deprecated.
@@ -322,8 +324,7 @@
* Windows: https://ci.appveyor.com/project/msberends/amr
* Added thesis advisors to DESCRIPTION file
# 0.2.0
**Published on CRAN: 2018-05-03**
# AMR 0.2.0
#### New
* Full support for Windows, Linux and macOS
@@ -359,8 +360,7 @@
* Added build tests for Linux and macOS using Travis CI (https://travis-ci.org/msberends/AMR)
* Added line coverage checking using CodeCov (https://codecov.io/gh/msberends/AMR/tree/master/R)
# 0.1.1
**Published on CRAN: 2018-03-14**
# AMR 0.1.1
* `EUCAST_rules` applies for amoxicillin even if ampicillin is missing
* Edited column names to comply with GLIMS, the laboratory information system
@@ -368,7 +368,6 @@
* Renamed 'Daily Defined Dose' to 'Defined Daily Dose'
* Added barplots for `rsi` and `mic` classes
# 0.1.0
**Published on CRAN: 2018-02-22**
# AMR 0.1.0
* First submission to CRAN.

346
R/freq.R
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@@ -25,7 +25,7 @@
#' @param nmax number of row to print. The default, \code{15}, uses \code{\link{getOption}("max.print.freq")}. Use \code{nmax = 0}, \code{nmax = Inf}, \code{nmax = NULL} or \code{nmax = NA} to print all rows.
#' @param na.rm a logical value indicating whether \code{NA} values should be removed from the frequency table. The header (if set) will always print the amount of \code{NA}s.
#' @param row.names a logical value indicating whether row indices should be printed as \code{1:nrow(x)}
#' @param markdown a logical value indicating whether the frequency table should be printed in markdown format. This will print all rows and is default behaviour in non-interactive R sessions (like when knitting RMarkdown files).
#' @param markdown a logical value indicating whether the frequency table should be printed in markdown format. This will print all rows (except when \code{nmax} is defined) and is default behaviour in non-interactive R sessions (like when knitting RMarkdown files).
#' @param digits how many significant digits are to be used for numeric values in the header (not for the items themselves, that depends on \code{\link{getOption}("digits")})
#' @param quote a logical value indicating whether or not strings should be printed with surrounding quotes
#' @param header a logical value indicating whether an informative header should be printed
@@ -36,6 +36,7 @@
#' @inheritParams base::format
#' @param f a frequency table
#' @param n number of top \emph{n} items to return, use -n for the bottom \emph{n} items. It will include more than \code{n} rows if there are ties.
#' @param property property in header to return this value directly
#' @details Frequency tables (or frequency distributions) are summaries of the distribution of values in a sample. With the `freq` function, you can create univariate frequency tables. Multiple variables will be pasted into one variable, so it forces a univariate distribution. This package also has a vignette available to explain the use of this function further, run \code{browseVignettes("AMR")} to read it.
#'
#' For numeric values of any class, these additional values will all be calculated with \code{na.rm = TRUE} and shown into the header:
@@ -309,51 +310,22 @@ frequency_tbl <- function(x,
class(x) <- x_class
}
header_txt <- character(0)
markdown_line <- ""
if (markdown == TRUE) {
markdown_line <- "\n"
markdown_line <- " "
}
x_align <- "l"
if (mult.columns > 0) {
header_txt <- header_txt %>% paste0(markdown_line, "Columns: ", mult.columns)
header_list <- list(columns = mult.columns)
} else {
header_txt <- header_txt %>% paste0(markdown_line, "Class: ", class(x) %>% rev() %>% paste(collapse = " > "))
if (!mode(x) %in% class(x)) {
header_txt <- header_txt %>% paste0(silver(paste0(" (", mode(x), ")")))
}
}
if ((length(NAs) + length(x) > 0) > 0) {
na_txt <- paste0(NAs %>% length() %>% format(decimal.mark = decimal.mark, big.mark = big.mark), " = ",
(NAs %>% length() / (NAs %>% length() + x %>% length())) %>% percent(force_zero = TRUE, round = digits, decimal.mark = decimal.mark) %>%
sub("NaN", "0", ., fixed = TRUE))
if (!na_txt %like% "^0 =") {
na_txt <- red(na_txt)
} else {
na_txt <- green(na_txt)
}
na_txt <- paste0("(of which NA: ", na_txt, ")")
} else {
na_txt <- ""
header_list <- list(class = class(x),
mode = mode(x))
}
if (!is.null(levels(x))) {
n_levels <- x %>% levels() %>% length()
n_levels_empty <- n_levels - x %>% droplevels() %>% levels() %>% length()
n_levels_list <- levels(x)
if (n_levels > 5) {
n_levels_list <- c(n_levels_list[1:5], "...")
}
if (is.ordered(x)) {
n_levels_list <- paste0(levels(x), collapse = " < ")
} else {
n_levels_list <- paste0(levels(x), collapse = ", ")
}
header_txt <- header_txt %>% paste0(markdown_line, "\nLevels: ", n_levels_list)
header_list$levels <- levels(x)
header_list$ordered <- is.ordered(x)
# drop levels of non-existing factor values,
# since dplyr >= 0.8.0 does not do this anymore in group_by
if (droplevels == TRUE) {
@@ -361,58 +333,45 @@ frequency_tbl <- function(x,
}
}
header_txt <- header_txt %>% paste0(markdown_line, "\nLength: ", (NAs %>% length() + x %>% length()) %>% format(decimal.mark = decimal.mark, big.mark = big.mark),
" ", na_txt)
header_txt <- header_txt %>% paste0(markdown_line, "\nUnique: ", x %>% n_distinct() %>% format(decimal.mark = decimal.mark, big.mark = big.mark))
header_list$length <- length(x)
header_list$na_length <- length(NAs)
header_list$unique <- n_distinct(x)
if (NROW(x) > 0 & any(class(x) == "character")) {
header_txt <- header_txt %>% paste0("\n")
header_txt <- header_txt %>% paste0(markdown_line, "\nShortest: ", x %>% base::nchar() %>% base::min(na.rm = TRUE) %>% format(decimal.mark = decimal.mark, big.mark = big.mark))
header_txt <- header_txt %>% paste0(markdown_line, "\nLongest: ", x %>% base::nchar() %>% base::max(na.rm = TRUE) %>% format(decimal.mark = decimal.mark, big.mark = big.mark))
header_list$shortest <- x %>% base::nchar() %>% base::min(na.rm = TRUE)
header_list$longest <- x %>% base::nchar() %>% base::max(na.rm = TRUE)
}
if (NROW(x) > 0 & any(class(x) == "mo")) {
header_txt <- header_txt %>% paste0("\n")
header_txt <- header_txt %>% paste0(markdown_line, "\nFamilies: ", x %>% mo_family() %>% n_distinct() %>% format(decimal.mark = decimal.mark, big.mark = big.mark))
header_txt <- header_txt %>% paste0(markdown_line, "\nGenera: ", x %>% mo_genus() %>% n_distinct() %>% format(decimal.mark = decimal.mark, big.mark = big.mark))
header_txt <- header_txt %>% paste0(markdown_line, "\nSpecies: ", x %>% mo_species() %>% n_distinct() %>% format(decimal.mark = decimal.mark, big.mark = big.mark))
header_list$families <- x %>% mo_family() %>% n_distinct()
header_list$genera <- x %>% mo_genus() %>% n_distinct()
header_list$species <- x %>% mo_species() %>% n_distinct()
}
if (NROW(x) > 0 & any(class(x) == "difftime") & !is.hms(x)) {
header_txt <- header_txt %>% paste0("\n")
header_txt <- header_txt %>% paste(markdown_line, "\nUnits: ", attributes(x)$units)
header_list$units <- attributes(x)$units
x <- as.double(x)
# after this, the numeric header_txt continues
}
if (NROW(x) > 0 & any(class(x) %in% c("double", "integer", "numeric", "raw", "single"))) {
# right align number
Tukey_five <- stats::fivenum(x, na.rm = TRUE)
x_align <- "r"
header_txt <- header_txt %>% paste0("\n")
header_txt <- header_txt %>% paste(markdown_line, "\nMean: ", x %>% base::mean(na.rm = TRUE) %>% format(digits = digits, decimal.mark = decimal.mark, big.mark = big.mark))
header_txt <- header_txt %>% paste0(markdown_line, "\nStd. dev.: ", x %>% stats::sd(na.rm = TRUE) %>% format(digits = digits, decimal.mark = decimal.mark, big.mark = big.mark),
" (CV: ", x %>% cv(na.rm = TRUE) %>% format(digits = digits, decimal.mark = decimal.mark, big.mark = big.mark),
", MAD: ", x %>% stats::mad(na.rm = TRUE) %>% format(digits = digits, decimal.mark = decimal.mark, big.mark = big.mark), ")")
header_txt <- header_txt %>% paste0(markdown_line, "\nFive-Num: ", Tukey_five %>% format(digits = digits, decimal.mark = decimal.mark, big.mark = big.mark) %>% trimws() %>% paste(collapse = " | "),
" (IQR: ", (Tukey_five[4] - Tukey_five[2]) %>% format(digits = digits, decimal.mark = decimal.mark, big.mark = big.mark),
", CQV: ", x %>% cqv(na.rm = TRUE) %>% format(digits = digits, decimal.mark = decimal.mark, big.mark = big.mark), ")")
outlier_length <- length(boxplot.stats(x)$out)
header_txt <- header_txt %>% paste0(markdown_line, "\nOutliers: ", outlier_length)
if (outlier_length > 0) {
header_txt <- header_txt %>% paste0(" (unique count: ", boxplot.stats(x)$out %>% n_distinct(), ")")
}
header_list$mean <- base::mean(x, na.rm = TRUE)
header_list$sd <- stats::sd(x, na.rm = TRUE)
header_list$cv <- cv(x, na.rm = TRUE)
header_list$mad <- stats::mad(x, na.rm = TRUE)
Tukey_five <- stats::fivenum(x, na.rm = TRUE)
header_list$fivenum <- Tukey_five
header_list$IQR <- Tukey_five[4] - Tukey_five[2]
header_list$cqv <- cqv(x, na.rm = TRUE)
header_list$outliers_total <- length(boxplot.stats(x)$out)
header_list$outliers_unique <- n_distinct(boxplot.stats(x)$out)
}
if (NROW(x) > 0 & any(class(x) == "rsi")) {
header_txt <- header_txt %>% paste0("\n")
cnt_S <- sum(x == "S", na.rm = TRUE)
cnt_IR <- sum(x %in% c("I", "R"), na.rm = TRUE)
header_txt <- header_txt %>% paste(markdown_line, "\n%IR: ",
(cnt_IR / sum(!is.na(x), na.rm = TRUE)) %>% percent(force_zero = TRUE, round = digits, decimal.mark = decimal.mark),
paste0("(ratio S : IR = 1.0 : ", (cnt_IR / cnt_S) %>% format(digits = 1, nsmall = 1, decimal.mark = decimal.mark, big.mark = big.mark), ")"))
if (NROW(x) < 30) {
header_txt <- header_txt %>% paste(markdown_line, red("\nToo few isolates for reliable resistance interpretation."))
}
header_list$count_S <- sum(x == "S", na.rm = TRUE)
header_list$count_IR <- sum(x %in% c("I", "R"), na.rm = TRUE)
}
formatdates <- "%e %B %Y" # = d mmmm yyyy
@@ -421,26 +380,18 @@ frequency_tbl <- function(x,
formatdates <- "%H:%M:%S"
}
if (NROW(x) > 0 & any(class(x) %in% c("Date", "POSIXct", "POSIXlt"))) {
header_txt <- header_txt %>% paste0("\n")
mindate <- x %>% min(na.rm = TRUE)
maxdate <- x %>% max(na.rm = TRUE)
maxdate_days <- difftime(maxdate, mindate, units = "auto") %>% as.double()
mediandate <- x %>% median(na.rm = TRUE)
median_days <- difftime(mediandate, mindate, units = "auto") %>% as.double()
if (formatdates == "%H:%M:%S") {
# hms
header_txt <- header_txt %>% paste0(markdown_line, "\nEarliest: ", mindate %>% format(formatdates) %>% trimws())
header_txt <- header_txt %>% paste0(markdown_line, "\nLatest: ", maxdate %>% format(formatdates) %>% trimws(),
" (+", difftime(maxdate, mindate, units = "mins") %>% as.double() %>% format(digits = digits, decimal.mark = decimal.mark, big.mark = big.mark), " min.)")
header_list$earliest <- min(x, na.rm = TRUE)
header_list$latest <- max(x, na.rm = TRUE)
} else {
# other date formats
header_txt <- header_txt %>% paste0(markdown_line, "\nOldest: ", mindate %>% format(formatdates) %>% trimws())
header_txt <- header_txt %>% paste0(markdown_line, "\nNewest: ", maxdate %>% format(formatdates) %>% trimws(),
" (+", difftime(maxdate, mindate, units = "auto") %>% as.double() %>% format(digits = digits, decimal.mark = decimal.mark, big.mark = big.mark), ")")
header_list$oldest <- min(x, na.rm = TRUE)
header_list$newest <- max(x, na.rm = TRUE)
}
header_txt <- header_txt %>% paste0(markdown_line, "\nMedian: ", mediandate %>% format(formatdates) %>% trimws(),
" (~", percent(median_days / maxdate_days, round = 0, decimal.mark = decimal.mark), ")")
header_list$median <- median(x, na.rm = TRUE)
header_list$date_format <- formatdates
}
if (any(class(x) == "POSIXlt")) {
x <- x %>% format(formatdates)
@@ -463,10 +414,13 @@ frequency_tbl <- function(x,
column_align <- c(x_align, "r", "r", "r", "r")
if (is.null(df)) {
# create table with counts and percentages
df <- tibble(item = x) %>%
group_by(item) %>%
summarise(count = n())
suppressWarnings( # suppress since dplyr 0.8.0, which idiotly warns about included NAs :(
# create table with counts and percentages
df <- tibble(item = x) %>%
group_by(item) %>%
summarise(count = n())
)
# sort according to setting
if (sort.count == TRUE) {
@@ -515,14 +469,18 @@ frequency_tbl <- function(x,
title <- trimws(gsub("^Frequency table of", "", title[1L], ignore.case = TRUE))
}
# if (nmax.set == FALSE) {
# nmax <- nrow(df)
# }
structure(.Data = df,
class = c("frequency_tbl", class(df)),
header = header_list,
opt = list(title = title,
data = x.name,
vars = cols,
group_var = x.group,
header = header,
header_txt = header_txt,
row_names = row.names,
column_names = column_names,
column_align = column_align,
@@ -530,6 +488,7 @@ frequency_tbl <- function(x,
big.mark = big.mark,
tbl_format = tbl_format,
na = na,
digits = digits,
nmax = nmax,
nmax.set = nmax.set))
}
@@ -538,6 +497,144 @@ frequency_tbl <- function(x,
#' @export
freq <- frequency_tbl
#' @importFrom crayon silver green red
#' @importFrom dplyr %>%
format_header <- function(x, markdown = FALSE, decimal.mark = ".", big.mark = ",", digits = 2) {
newline <-"\n"
if (markdown == TRUE) {
newline <- " \n"
}
header <- header(x)
x_class <- header$class
has_length <- header$length + header$na_length > 0
# FORMATTING
# rsi
if (has_length == TRUE & any(x_class == "rsi")) {
header$`%IR` <- paste((header$count_IR / header$length) %>% percent(force_zero = TRUE, round = digits, decimal.mark = decimal.mark),
paste0("(ratio S : IR = 1.0 : ", (header$count_IR / header$count_S) %>% format(digits = 1, nsmall = 1, decimal.mark = decimal.mark, big.mark = big.mark), ")"))
header <- header[!names(header) %in% c("count_S", "count_IR")]
}
# dates
if (!is.null(header$date_format)) {
if (header$date_format == "%H:%M:%S") {
header$median <- paste0(format(header$median, header$date_format),
" (",
(as.double(difftime(header$median, header$earliest, units = "auto")) /
as.double(difftime(header$latest, header$earliest, units = "auto"))) %>%
percent(round = digits, decimal.mark = decimal.mark), ")")
header$latest <- paste0(format(header$latest, header$date_format),
" (+",
difftime(header$latest, header$earliest, units = "mins") %>%
as.double() %>%
format(digits = digits, decimal.mark = decimal.mark, big.mark = big.mark),
" min.)")
header$earliest <- format(header$earliest, header$date_format)
header$median <- trimws(header$median)
header$latest <- trimws(header$latest)
header$earliest <- trimws(header$earliest)
} else {
header$median <- paste0(format(header$median, header$date_format),
" (",
(as.double(difftime(header$median, header$oldest, units = "auto")) /
as.double(difftime(header$newest, header$oldest, units = "auto"))) %>%
percent(round = digits, decimal.mark = decimal.mark), ")")
header$newest <- paste0(format(header$newest, header$date_format),
" (+",
difftime(header$newest, header$oldest, units = "auto") %>%
as.double() %>%
format(digits = digits, decimal.mark = decimal.mark, big.mark = big.mark),
")")
header$oldest <- format(header$oldest, header$date_format)
header$median <- trimws(header$median)
header$newest <- trimws(header$newest)
header$oldest <- trimws(header$oldest)
}
header <- header[names(header) != "date_format"]
}
# class and mode
if (is.null(header$columns)) {
if (!header$mode %in% header$class) {
header$class <- header$class %>% rev() %>% paste(collapse = " > ") %>% paste0(silver(paste0(" (", header$mode, ")")))
} else {
header$class <- header$class %>% rev() %>% paste(collapse = " > ")
}
header <- header[names(header) != "mode"]
}
# levels
if (!is.null(header$levels)) {
n_levels <- header$levels %>% length()
n_levels_list <- header$levels
if (n_levels > 5) {
n_levels_list <- c(n_levels_list[1:5], "...")
}
if (header$ordered == TRUE) {
n_levels_list <- paste0(header$levels, collapse = " < ")
} else {
n_levels_list <- paste0(header$levels, collapse = ", ")
}
header$levels <- n_levels_list
header <- header[names(header) != "ordered"]
}
# length and NAs
if (has_length == TRUE) {
na_txt <- paste0(header$na_length %>% format(decimal.mark = decimal.mark, big.mark = big.mark), " = ",
(header$na_length / (header$na_length + header$length)) %>% percent(force_zero = TRUE, round = digits, decimal.mark = decimal.mark) %>%
sub("NaN", "0", ., fixed = TRUE))
if (!na_txt %like% "^0 =") {
na_txt <- red(na_txt)
} else {
na_txt <- green(na_txt)
}
na_txt <- paste0("(of which NA: ", na_txt, ")")
} else {
na_txt <- ""
}
header$length <- paste((header$na_length + header$length) %>% format(decimal.mark = decimal.mark, big.mark = big.mark),
na_txt)
header <- header[names(header) != "na_length"]
# format all numeric values
header <- lapply(header, function(x)
if (is.numeric(x))
if (any(x < 1000)) {
format(round2(x, digits = digits), decimal.mark = decimal.mark, big.mark = big.mark)
} else {
format(x, digits = digits, decimal.mark = decimal.mark, big.mark = big.mark)
}
else
x
)
# numeric values
if (has_length == TRUE & any(x_class %in% c("double", "integer", "numeric", "raw", "single"))) {
header$sd <- paste0(header$sd, " (CV: ", header$cv, ", MAD: ", header$mad, ")")
header$fivenum <- paste0(paste(header$fivenum, collapse = " | "), " (IQR: ", header$IQR, ", CQV: ", header$cqv, ")")
header$outliers_total <- paste0(header$outliers_total, " (unique count: ", header$outliers_unique, ")")
header <- header[!names(header) %in% c("cv", "mad", "IQR", "cqv", "outliers_unique")]
}
# header names
header_names <- paste0(names(header), ": ")
header_names <- gsub("sd", "SD", header_names)
header_names <- gsub("fivenum", "Five-Num", header_names)
header_names <- gsub("outliers_total", "Outliers", header_names)
# capitalise first character
header_names <- gsub("^(.)", "\\U\\1", header_names, perl = TRUE)
# make all header captions equal size
header_names <- gsub("\\s", " ", format(header_names,
width = max(nchar(header_names),
na.rm = TRUE)))
header <- paste0(header_names, header)
header <- paste(header, collapse = newline)
# add newline after 'Unique'
gsub("(.*Unique.*\\n)(.*?)", paste0("\\1", newline, "\\2"), header)
}
#' @rdname freq
#' @export
#' @importFrom dplyr top_n pull
@@ -557,6 +654,19 @@ top_freq <- function(f, n) {
vect
}
#' @rdname freq
#' @export
header <- function(f, property = NULL) {
if (is.null(property)) {
attributes(f)$header
} else {
a <- attributes(f)$header
if (any(property %in% names(f))) {
a[names(a) %in% property]
}
}
}
#' @noRd
#' @exportMethod diff.frequency_tbl
#' @importFrom dplyr %>% full_join mutate
@@ -615,13 +725,16 @@ diff.frequency_tbl <- function(x, y, ...) {
#' @importFrom dplyr n_distinct
#' @importFrom crayon bold silver
#' @export
print.frequency_tbl <- function(x, nmax = getOption("max.print.freq", default = 15),
markdown = !interactive(), header = !markdown,
print.frequency_tbl <- function(x,
nmax = getOption("max.print.freq", default = 15),
markdown = !interactive(),
header = !markdown,
decimal.mark = getOption("OutDec"),
big.mark = ifelse(decimal.mark != ",", ",", "."),
...) {
opt <- attr(x, "opt")
opt$header_txt <- header(x)
if (length(opt$vars) == 0) {
opt$vars <- NULL
@@ -658,6 +771,13 @@ print.frequency_tbl <- function(x, nmax = getOption("max.print.freq", default =
opt$nmax <- nmax
opt$nmax.set <- TRUE
}
if (opt$nmax %in% c(0, Inf, NA, NULL)) {
opt$nmax <- NROW(x)
opt$nmax.set <- FALSE
} else if (opt$nmax >= NROW(x)) {
opt$nmax.set <- FALSE
}
if (!missing(decimal.mark)) {
opt$decimal.mark <- decimal.mark
}
@@ -673,7 +793,15 @@ print.frequency_tbl <- function(x, nmax = getOption("max.print.freq", default =
}
}
if (!missing(markdown)) {
opt$tbl_format <- "markdown"
if (markdown == TRUE) {
opt$tbl_format <- "markdown"
if (missing(header)) {
# default header off for markdown
header <- FALSE
}
} else {
opt$tbl_format <- "pandoc"
}
}
if (!missing(header)) {
opt$header <- header
@@ -689,7 +817,10 @@ print.frequency_tbl <- function(x, nmax = getOption("max.print.freq", default =
if (opt$header == TRUE) {
cat(title, "\n")
if (!is.null(opt$header_txt)) {
cat(opt$header_txt)
if (is.null(opt$digits)) {
opt$digits <- 2
}
cat(format_header(x, digits = opt$digits, markdown = markdown, decimal.mark = decimal.mark, big.mark = big.mark))
}
} else if (opt$tbl_format == "markdown") {
# do print title as caption in markdown
@@ -708,11 +839,11 @@ print.frequency_tbl <- function(x, nmax = getOption("max.print.freq", default =
}
options(knitr.kable.NA = opt$na)
if (nrow(x) > opt$nmax & opt$tbl_format != "markdown") {
x.rows <- nrow(x)
x.unprinted <- base::sum(x[(opt$nmax + 1):nrow(x), "count"], na.rm = TRUE)
x.printed <- base::sum(x$count) - x.unprinted
x.rows <- nrow(x)
x.unprinted <- base::sum(x[(opt$nmax + 1):nrow(x), "count"], na.rm = TRUE)
x.printed <- base::sum(x$count) - x.unprinted
if (nrow(x) > opt$nmax & opt$tbl_format != "markdown") {
if (opt$nmax.set == TRUE) {
nmax <- opt$nmax
@@ -729,15 +860,28 @@ print.frequency_tbl <- function(x, nmax = getOption("max.print.freq", default =
}
footer <- paste(footer,
" -- omitted ",
format(x.rows - opt$nmax, big.mark = opt$big.mark),
format(x.rows - opt$nmax, big.mark = opt$big.mark, decimal.mark = opt$decimal.mark),
" entries, n = ",
format(x.unprinted, big.mark = opt$big.mark),
format(x.unprinted, big.mark = opt$big.mark, decimal.mark = opt$decimal.mark),
" (",
(x.unprinted / (x.unprinted + x.printed)) %>% percent(force_zero = TRUE, decimal.mark = opt$decimal.mark),
") ]\n", sep = "")
if (opt$tbl_format == "pandoc") {
footer <- silver(footer) # only silver in regular printing
}
} else if (opt$tbl_format == "markdown") {
if (opt$nmax.set == TRUE) {
x <- x[1:opt$nmax,]
footer <- paste("\n(omitted ",
format(x.rows - opt$nmax, big.mark = opt$big.mark, decimal.mark = opt$decimal.mark),
" entries, n = ",
format(x.unprinted, big.mark = opt$big.mark, decimal.mark = opt$decimal.mark),
" [",
(x.unprinted / (x.unprinted + x.printed)) %>% percent(force_zero = TRUE, decimal.mark = opt$decimal.mark),
"])\n", sep = "")
} else {
footer <- NULL
}
} else {
footer <- NULL
}

19
R/mic.R
View File

@@ -61,6 +61,9 @@ as.mic <- function(x, na.rm = FALSE) {
x <- gsub('[^0-9]+$', '', x)
# remove last zeroes
x <- gsub('([.].?)0+$', '\\1', x)
x <- gsub('(.*[.])0+$', '\\10', x)
# remove ending .0 again
x <- gsub('[.]+0$', '', x)
# force to be character
x <- as.character(x)
@@ -182,6 +185,15 @@ as.numeric.mic <- function(x, ...) {
as.numeric(gsub('(<|=|>)+', '', as.character(x)))
}
#' @exportMethod droplevels.mic
#' @export
#' @noRd
droplevels.mic <- function(x, exclude = if(anyNA(levels(x))) NULL else NA, ...) {
x <- droplevels.factor(x, exclude = exclude, ...)
class(x) <- c('mic', 'ordered', 'factor')
x
}
#' @exportMethod print.mic
#' @export
#' @importFrom dplyr %>% tibble group_by summarise pull
@@ -230,11 +242,10 @@ barplot.mic <- function(height, ...) {
#' @importFrom graphics barplot axis
#' @importFrom dplyr %>% group_by summarise
create_barplot_mic <- function(x, x_name, ...) {
data <- data.frame(mic = x, cnt = 1) %>%
data <- data.frame(mic = droplevels(x), cnt = 1) %>%
group_by(mic) %>%
summarise(cnt = sum(cnt)) %>%
droplevels()
barplot(table(droplevels(x)),
summarise(cnt = sum(cnt))
barplot(table(droplevels.factor(x)),
ylab = 'Frequency',
xlab = 'MIC value',
main = paste('MIC values of', x_name),

13
R/misc.R
View File

@@ -27,10 +27,15 @@ addin_insert_like <- function() {
}
# No export, no Rd
# works exactly like round(), but rounds `round(0.55, 1)` as 0.6
round2 <- function(x, digits = 0) {
# works exactly like round(), but rounds `round(44.55, 1)` as 44.6 instead of 44.5 and adds decimal zeroes until `digits` is reached
round2 <- function(x, digits = 0, force_zero = TRUE) {
# https://stackoverflow.com/a/12688836/4575331
(trunc((abs(x) * 10 ^ digits) + 0.5) / 10 ^ digits) * sign(x)
val <- (trunc((abs(x) * 10 ^ digits) + 0.5) / 10 ^ digits) * sign(x)
if (digits > 0 & force_zero == TRUE) {
val[val != as.integer(val)] <- paste0(val[val != as.integer(val)],
strrep("0", max(0, digits - nchar(gsub(".*[.](.*)$", "\\1", val[val != as.integer(val)])))))
}
val
}
# No export, no Rd
@@ -39,7 +44,7 @@ percent <- function(x, round = 1, force_zero = FALSE, decimal.mark = getOption("
decimal.mark.options <- getOption("OutDec")
options(OutDec = ".")
val <- round2(x, round + 2) # round up 0.5
val <- round2(x, round + 2, force_zero = FALSE) # round up 0.5
val <- round(x = val * 100, digits = round) # remove floating point error
if (force_zero == TRUE) {

36
R/rsi.R
View File

@@ -129,6 +129,15 @@ print.rsi <- function(x, ...) {
print(as.character(x), quote = FALSE)
}
#' @exportMethod droplevels.rsi
#' @export
#' @noRd
droplevels.rsi <- function(x, exclude = if(anyNA(levels(x))) NULL else NA, ...) {
x <- droplevels.factor(x, exclude = exclude, ...)
class(x) <- c('rsi', 'ordered', 'factor')
x
}
#' @exportMethod summary.rsi
#' @export
#' @noRd
@@ -152,13 +161,16 @@ summary.rsi <- function(object, ...) {
plot.rsi <- function(x, ...) {
x_name <- deparse(substitute(x))
data <- data.frame(x = x,
y = 1,
stringsAsFactors = TRUE) %>%
group_by(x) %>%
summarise(n = sum(y)) %>%
filter(!is.na(x)) %>%
mutate(s = round((n / sum(n)) * 100, 1))
suppressWarnings(
data <- data.frame(x = x,
y = 1,
stringsAsFactors = TRUE) %>%
group_by(x) %>%
summarise(n = sum(y)) %>%
filter(!is.na(x)) %>%
mutate(s = round((n / sum(n)) * 100, 1))
)
data$x <- factor(data$x, levels = c('S', 'I', 'R'), ordered = TRUE)
ymax <- if_else(max(data$s) > 95, 105, 100)
@@ -193,10 +205,12 @@ barplot.rsi <- function(height, ...) {
x <- height
x_name <- deparse(substitute(height))
data <- data.frame(rsi = x, cnt = 1) %>%
group_by(rsi) %>%
summarise(cnt = sum(cnt)) %>%
droplevels()
suppressWarnings(
data <- data.frame(rsi = x, cnt = 1) %>%
group_by(rsi) %>%
summarise(cnt = sum(cnt)) %>%
droplevels()
)
barplot(table(x),
col = c('green3', 'orange2', 'red3'),

2
README.md
View File

@@ -1,4 +1,4 @@
# `AMR` <img src="man/figures/logo_amr.png" align="right" height="120px" />
# `AMR` <img src="man/figures/logo.png" align="right" height="120px" />
### An [R package](https://www.r-project.org) to simplify the analysis and prediction of Antimicrobial Resistance (AMR) and to work with antibiotic properties by using evidence-based methods.
This R package was created for academic research by PhD students of the Faculty of Medical Sciences of the [University of Groningen](https://www.rug.nl) and the Medical Microbiology & Infection Prevention (MMBI) department of the [University Medical Center Groningen (UMCG)](https://www.umcg.nl).

110
_pkgdown.yml Normal file
View File

@@ -0,0 +1,110 @@
url: https://msberends.gitlab.io
title: 'AMR (for R)'
navbar:
title: 'AMR (for R)'
left:
- text: 'Home'
icon: 'fa-home'
href: 'index.html'
- text: 'Get Started'
icon: 'fa-directions'
href: 'articles/AMR.html'
- text: 'Manual'
icon: 'fa-book-open'
href: 'reference/'
- text: 'Authors'
icon: 'fa-users'
href: 'authors.html'
- text: 'Changelog'
icon: 'far fa-newspaper'
href: 'news/'
- text: 'Source Code'
icon: 'fab fa-gitlab'
href: 'https://gitlab.com/msberends/AMR'
right:
- text: 'Licence'
icon: 'fa-book'
href: 'LICENSE-text.html'
reference:
- title: Cleaning your data
desc: >
Functions for cleaning and optimising your data, to be able
to add variables later on (like taxonomic properties) or to
fix and extend antibiotic interpretations by applying EUCAST rules.
contents:
- starts_with("as.")
- '`eucast_rules`'
- '`read.4D`'
- title: Adding variables to your data
desc: >
Functions to add new data to existing data, like the determination
of first isolates,
contents:
- '`first_isolate`'
- '`mdro`'
- '`key_antibiotics`'
- '`mo_property`'
- '`ab_property`'
- '`atc_property`'
- '`abname`'
- '`age`'
- '`age_groups`'
- '`p.symbol`'
- '`join`'
- title: Analysing your data
desc: >
Functions for conducting AMR analysis
contents:
- '`count`'
- '`portion`'
- '`freq`'
- '`g.test`'
- '`ggplot_rsi`'
- '`kurtosis`'
- '`resistance_predict`'
- '`rsi`'
- '`skewness`'
- title: Included data sets
desc: >
References for microorganisms and antibiotics, and even a
genuine data set with isolates from septic patients.
contents:
- '`antibiotics`'
- '`microorganisms`'
- '`septic_patients`'
- '`microorganisms.certe`'
- '`microorganisms.old`'
- '`microorganisms.umcg`'
- '`supplementary_data`'
- title: Other
desc: ~
contents:
- '`get_locale`'
- '`like`'
- '`mo_failures`'
- '`mo_renamed`'
authors:
Matthijs S. Berends:
href: https://www.rug.nl/staff/m.s.berends/
Christian F. Luz:
href: https://www.rug.nl/staff/c.f.luz/
Corinna Glasner:
href: https://www.rug.nl/staff/c.glasner/
Alex W. Friedrich:
href: https://www.rug.nl/staff/a.w.friedrich/
Bhanu N. M. Sinha:
href: https://www.rug.nl/staff/b.sinha/
template:
assets: pkgdown/logos
params:
noindex: false
bootswatch: flatly
docsearch:
# using algolia.com
api_key: 'f737050abfd4d726c63938e18f8c496e'
index_name: 'amr'

1
docs/CNAME Normal file
View File

@@ -0,0 +1 @@
msberends.gitlab.io

106
public/LICENSE-text.html → docs/LICENSE-text.html
View File

@@ -6,13 +6,20 @@
<meta http-equiv="X-UA-Compatible" content="IE=edge">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title>License • AMR</title>
<title>License • AMR (for R)</title>
<!-- favicons -->
<link rel="icon" type="image/png" sizes="16x16" href="favicon-16x16.png">
<link rel="icon" type="image/png" sizes="32x32" href="favicon-32x32.png">
<link rel="apple-touch-icon" type="image/png" sizes="180x180" href="apple-touch-icon.png" />
<link rel="apple-touch-icon" type="image/png" sizes="120x120" href="apple-touch-icon-120x120.png" />
<link rel="apple-touch-icon" type="image/png" sizes="76x76" href="apple-touch-icon-76x76.png" />
<link rel="apple-touch-icon" type="image/png" sizes="60x60" href="apple-touch-icon-60x60.png" />
<!-- jquery -->
<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.3.1/jquery.min.js" integrity="sha256-FgpCb/KJQlLNfOu91ta32o/NMZxltwRo8QtmkMRdAu8=" crossorigin="anonymous"></script>
<!-- Bootstrap -->
<link href="https://cdnjs.cloudflare.com/ajax/libs/bootswatch/3.3.7/flatly/bootstrap.min.css" rel="stylesheet" crossorigin="anonymous" />
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.3.7/css/bootstrap.min.css" integrity="sha256-916EbMg70RQy9LHiGkXzG8hSg9EdNy97GazNG/aiY1w=" crossorigin="anonymous" />
<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.3.7/js/bootstrap.min.js" integrity="sha256-U5ZEeKfGNOja007MMD3YBI0A3OSZOQbeG6z2f2Y0hu8=" crossorigin="anonymous"></script>
<!-- Font Awesome icons -->
@@ -29,9 +36,20 @@
<script src="pkgdown.js"></script>
<!-- docsearch -->
<script src="docsearch.js"></script>
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/docsearch.js/2.6.1/docsearch.min.css" integrity="sha256-QOSRU/ra9ActyXkIBbiIB144aDBdtvXBcNc3OTNuX/Q=" crossorigin="anonymous" />
<link href="docsearch.css" rel="stylesheet">
<script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/jquery.mark.min.js" integrity="sha256-4HLtjeVgH0eIB3aZ9mLYF6E8oU5chNdjU6p6rrXpl9U=" crossorigin="anonymous"></script>
<link href="extra.css" rel="stylesheet">
<script src="extra.js"></script>
<meta property="og:title" content="License" />
<meta property="og:image" content="https://msberends.gitlab.io/logo.png" />
<meta name="twitter:card" content="summary" />
<!-- mathjax -->
@@ -59,8 +77,8 @@
<span class="icon-bar"></span>
</button>
<span class="navbar-brand">
<a class="navbar-link" href="index.html">AMR</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">0.5.0.9007</span>
<a class="navbar-link" href="index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">0.5.0.9008</span>
</span>
</div>
@@ -68,37 +86,64 @@
<ul class="nav navbar-nav">
<li>
<a href="index.html">
<span class="fa fa-home fa-lg"></span>
<span class="fa fa-home"></span>
Home
</a>
</li>
<li>
<a href="articles/AMR.html">Get started</a>
</li>
<li>
<a href="reference/index.html">Reference</a>
</li>
<li class="dropdown">
<a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false">
Articles
<a href="articles/AMR.html">
<span class="fa fa-directions"></span>
<span class="caret"></span>
Get Started
</a>
<ul class="dropdown-menu" role="menu">
<li>
<a href="articles/freq.html">Creating Frequency Tables</a>
</li>
</ul>
</li>
<li>
<a href="news/index.html">Changelog</a>
<a href="reference/">
<span class="fa fa-book-open"></span>
Manual
</a>
</li>
<li>
<a href="authors.html">
<span class="fa fa-users"></span>
Authors
</a>
</li>
<li>
<a href="news/">
<span class="far fa far fa-newspaper"></span>
Changelog
</a>
</li>
<li>
<a href="https://gitlab.com/msberends/AMR">
<span class="fab fa fab fa-gitlab"></span>
Source Code
</a>
</li>
</ul>
<ul class="nav navbar-nav navbar-right">
<li>
<a href="LICENSE-text.html">
<span class="fa fa-book"></span>
Licence
</a>
</li>
</ul>
<form class="navbar-form navbar-right" role="search">
<div class="form-group">
<input type="search" class="form-control" name="search-input" id="search-input" placeholder="Search..." aria-label="Search for..." autocomplete="off">
</div>
</form>
</div><!--/.nav-collapse -->
</div><!--/.container -->
</div><!--/.navbar -->
@@ -460,7 +505,7 @@ Public License instead of this License.
<footer>
<div class="copyright">
<p>Developed by Matthijs S. Berends, Christian F. Luz.</p>
<p>Developed by <a href='https://www.rug.nl/staff/m.s.berends/'>Matthijs S. Berends</a>, <a href='https://www.rug.nl/staff/c.f.luz/'>Christian F. Luz</a>, <a href='https://www.rug.nl/staff/c.glasner/'>Corinna Glasner</a>, <a href='https://www.rug.nl/staff/a.w.friedrich/'>Alex W. Friedrich</a>, <a href='https://www.rug.nl/staff/b.sinha/'>Bhanu N. M. Sinha</a>.</p>
</div>
<div class="pkgdown">
@@ -470,6 +515,23 @@ Public License instead of this License.
</div>
<script src="https://cdnjs.cloudflare.com/ajax/libs/docsearch.js/2.6.1/docsearch.min.js" integrity="sha256-GKvGqXDznoRYHCwKXGnuchvKSwmx9SRMrZOTh2g4Sb0=" crossorigin="anonymous"></script>
<script>
docsearch({
apiKey: 'f737050abfd4d726c63938e18f8c496e',
indexName: 'amr',
inputSelector: 'input#search-input.form-control',
transformData: function(hits) {
return hits.map(function (hit) {
hit.url = updateHitURL(hit);
return hit;
});
}
});
</script>
</body>
</html>

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@@ -0,0 +1,165 @@
<!DOCTYPE html>
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<h1>The AMR package - How to conduct AMR analysis</h1>
<h4 class="author">Matthijs S. Berends</h4>
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<p><strong><a href='https://www.rug.nl/staff/m.s.berends/'>Matthijs S. Berends</a></strong>. Author, maintainer. <a href='https://orcid.org/0000-0001-7620-1800' target='orcid.widget'><img src='https://members.orcid.org/sites/default/files/vector_iD_icon.svg' class='orcid' alt='ORCID' height='16'></a>
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<p><strong>Erwin E. A. Hassing</strong>. Contributor.
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<p><strong><a href='https://www.rug.nl/staff/b.sinha/'>Bhanu N. M. Sinha</a></strong>. Author, thesis advisor. <a href='https://orcid.org/0000-0003-1634-0010' target='orcid.widget'><img src='https://members.orcid.org/sites/default/files/vector_iD_icon.svg' class='orcid' alt='ORCID' height='16'></a>
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<div id="amr-for-r" class="section level1">
<div class="page-header"><h1 class="hasAnchor">
<a href="#amr-for-r" class="anchor"></a><code>AMR</code> (for R) <img src="reference/figures/logo.png" align="right" height="120px">
</h1></div>
<p><em>(<help title="Too Long, Didn't Read">TLDR</help> - to find out how to conduct AMR analysis, please <a href="./articles/AMR.html">continue reading here to get started</a>.</em></p>
<hr>
<p><code>AMR</code> is a free and open-source <a href="https://www.r-project.org">R package</a> to simplify the analysis and prediction of <strong>Antimicrobial Resistance (AMR)</strong> and to work with antibiotic properties by using evidence-based methods.</p>
<p>We created this package for academic research at the Faculty of Medical Sciences of the University of Groningen and the Medical Microbiology &amp; Infection Prevention (MMBI) department of the University Medical Center Groningen (UMCG). We released this under the GNU General Public Licence v2.0 (GPL-2) which makes it free for everybody to use and distribute, for personal and commercial use, but it may <strong>not</strong> be used for patent purposes. Read further about our GPL-2 licence <a href="./LICENSE-text.html">here</a>.</p>
<p>This package is ready-to-use for a professional environment by specialists in the following fields:</p>
<ul>
<li>Medical Microbiology
<ul>
<li>Epidemiologists (both clinical microbiological and research)</li>
<li>Research Microbiologists</li>
<li>Biomedical Researchers</li>
<li>Research Pharmacologists</li>
</ul>
</li>
<li>Veterinary Microbiology
<ul>
<li>Research Veterinarians</li>
<li>Veterinary Epidemiologists</li>
<li>Biomedical Researchers</li>
</ul>
</li>
<li>Microbial Ecology
<ul>
<li>Soil Microbiologists</li>
<li>Extremophile Researchers</li>
<li>Astrobiologists</li>
</ul>
</li>
<li>Other specialists in any of the above fields:
<ul>
<li>Data Scientists/Data Analysts</li>
<li>Biotechnologists</li>
<li>Biochemists</li>
<li>Geneticists</li>
<li>Molecular Biologists/Microbiologists</li>
</ul>
</li>
<li>Developers
<ul>
<li>Package developers for R</li>
<li>Software developers</li>
<li>Web application developers</li>
</ul>
</li>
</ul>
<div id="get-this-package" class="section level3">
<h3 class="hasAnchor">
<a href="#get-this-package" class="anchor"></a>Get this package</h3>
<p>This package is available on the official R network. Install this package in R with:</p>
<div class="sourceCode" id="cb1"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb1-1" data-line-number="1"><span class="kw"><a href="https://www.rdocumentation.org/packages/utils/topics/install.packages">install.packages</a></span>(<span class="st">"AMR"</span>)</a></code></pre></div>
<p>It will be downloaded and installed automatically.</p>
</div>
<div id="get-started" class="section level3">
<h3 class="hasAnchor">
<a href="#get-started" class="anchor"></a>Get started</h3>
<p>To find out how to conduct AMR analysis, please <a href="./articles/AMR.html">continue reading here to get started</a> or click the button ‘Get Started’ in the top menu.</p>
<hr>
<p><a href="https://www.rug.nl"><img src="./logo_rug.png" height="60px"></a> <a href="https://www.umcg.nl"><img src="./logo_umcg.png" height="60px"></a> <a href="https://www.certe.nl"><img src="./logo_certe.png" height="60px"></a> <a href="http://www.eurhealth-1health.eu"><img src="./logo_eh1h.png" height="60px"></a> <a href="http://www.eurhealth-1health.eu"><img src="./logo_interreg.png" height="60px"></a></p>
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<h2>Links</h2>
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<li>Download from CRAN at <br><a href="https://cloud.r-project.org/package=AMR">https://​cloud.r-project.org/​package=AMR</a>
</li>
<li>Report a bug at <br><a href="https://gitlab.com/msberends/AMR/issues">https://​gitlab.com/​msberends/​AMR/​issues</a>
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<a href="https://www.rug.nl/staff/m.s.berends/">Matthijs S. Berends</a> <br><small class="roles"> Author, maintainer </small> <a href="https://orcid.org/0000-0001-7620-1800" target="orcid.widget"><img src="https://members.orcid.org/sites/default/files/vector_iD_icon.svg" class="orcid" alt="ORCID" height="16"></a> </li>
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<a href="https://www.rug.nl/staff/c.f.luz/">Christian F. Luz</a> <br><small class="roles"> Author, reviewer </small> <a href="https://orcid.org/0000-0001-5809-5995" target="orcid.widget"><img src="https://members.orcid.org/sites/default/files/vector_iD_icon.svg" class="orcid" alt="ORCID" height="16"></a> </li>
<li>
<a href="https://www.rug.nl/staff/c.glasner/">Corinna Glasner</a> <br><small class="roles"> Author, thesis advisor </small> <a href="https://orcid.org/0000-0003-1241-1328" target="orcid.widget"><img src="https://members.orcid.org/sites/default/files/vector_iD_icon.svg" class="orcid" alt="ORCID" height="16"></a> </li>
<li>
<a href="https://www.rug.nl/staff/a.w.friedrich/">Alex W. Friedrich</a> <br><small class="roles"> Author, thesis advisor </small> <a href="https://orcid.org/0000-0003-4881-038X" target="orcid.widget"><img src="https://members.orcid.org/sites/default/files/vector_iD_icon.svg" class="orcid" alt="ORCID" height="16"></a> </li>
<li>
<a href="https://www.rug.nl/staff/b.sinha/">Bhanu N. M. Sinha</a> <br><small class="roles"> Author, thesis advisor </small> <a href="https://orcid.org/0000-0003-1634-0010" target="orcid.widget"><img src="https://members.orcid.org/sites/default/files/vector_iD_icon.svg" class="orcid" alt="ORCID" height="16"></a> </li>
<li><a href="authors.html">All authors...</a></li>
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<p>Developed by <a href="https://www.rug.nl/staff/m.s.berends/">Matthijs S. Berends</a>, <a href="https://www.rug.nl/staff/c.f.luz/">Christian F. Luz</a>, <a href="https://www.rug.nl/staff/c.glasner/">Corinna Glasner</a>, <a href="https://www.rug.nl/staff/a.w.friedrich/">Alex W. Friedrich</a>, <a href="https://www.rug.nl/staff/b.sinha/">Bhanu N. M. Sinha</a>.</p>
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<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">0.5.0.9008</span>
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<h1>Changelog <small></small></h1>
</div>
<div id="amr-0-5-0-90xx" class="section level1">
<h1 class="page-header">
<a href="#amr-0-5-0-90xx" class="anchor"></a>AMR 0.5.0.90xx<small> Unreleased </small>
</h1>
<p><strong>Note: this is the development version, which will eventually be released as AMR 0.6.0.</strong></p>
<div id="new" class="section level4">
<h4 class="hasAnchor">
<a href="#new" class="anchor"></a>New</h4>
<ul>
<li>
<strong>BREAKING</strong>: removed deprecated functions, parameters and references to ‘bactid’. Use <code>as.mo</code> to identify an MO code.</li>
<li>New website: <a href="https://msberends.gitlab.io/AMR" class="uri">https://msberends.gitlab.io/AMR</a> (built with the great <a href="https://pkgdown.r-lib.org/"><code>pkgdown</code></a>)
<ul>
<li>Contains the complete manual of this package and all of its functions with an explanation of their parameters</li>
</ul>
</li>
<li>Support for <a href="https://dplyr.tidyverse.org"><code>dplyr</code></a> version 0.8.0</li>
<li>Function <code>mo_failures</code> to review values that could not be coerced to a valid MO code, using <code>as.mo</code>. This latter function will now only show a maximum of 25 uncoerced values.</li>
<li>Function <code>mo_renamed</code> to get a list of all returned values from <code>as.mo</code> that have had taxonomic renaming</li>
<li>Function <code>age</code> to calculate the (patients) age in years</li>
<li>Function <code>age_groups</code> to split ages into custom or predefined groups (like children or elderly). This allows for easier demographic antimicrobial resistance analysis per age group.</li>
<li>
<p>Functions <code>filter_first_isolate</code> and <code><a href="../reference/first_isolate.html">filter_first_weighted_isolate()</a></code> to shorten and fasten filtering on data sets with antimicrobial results, e.g.:</p>
<div class="sourceCode" id="cb1"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb1-1" data-line-number="1">septic_patients <span class="op">%&gt;%</span><span class="st"> </span><span class="kw"><a href="../reference/first_isolate.html">filter_first_isolate</a></span>()</a>
<a class="sourceLine" id="cb1-2" data-line-number="2"><span class="co"># or</span></a>
<a class="sourceLine" id="cb1-3" data-line-number="3"><span class="kw"><a href="../reference/first_isolate.html">filter_first_isolate</a></span>(septic_patients)</a></code></pre></div>
<p>is equal to:</p>
<div class="sourceCode" id="cb2"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb2-1" data-line-number="1">septic_patients <span class="op">%&gt;%</span></a>
<a class="sourceLine" id="cb2-2" data-line-number="2"><span class="st"> </span><span class="kw">mutate</span>(<span class="dt">only_firsts =</span> <span class="kw"><a href="../reference/first_isolate.html">first_isolate</a></span>(septic_patients, ...)) <span class="op">%&gt;%</span></a>
<a class="sourceLine" id="cb2-3" data-line-number="3"><span class="st"> </span><span class="kw"><a href="https://www.rdocumentation.org/packages/stats/topics/filter">filter</a></span>(only_firsts <span class="op">==</span><span class="st"> </span><span class="ot">TRUE</span>) <span class="op">%&gt;%</span></a>
<a class="sourceLine" id="cb2-4" data-line-number="4"><span class="st"> </span><span class="kw">select</span>(<span class="op">-</span>only_firsts)</a></code></pre></div>
</li>
</ul>
</div>
<div id="changed" class="section level4">
<h4 class="hasAnchor">
<a href="#changed" class="anchor"></a>Changed</h4>
<ul>
<li>Improvements for <code>as.mo</code>:
<ul>
<li>Finds better results when input is in other languages</li>
<li>Better handling for subspecies</li>
<li>Better handling for <em>Salmonellae</em>
</li>
<li>There will be looked for uncertain results at default - these results will be returned with an informative warning</li>
<li>Manual now contains more info about the algorithms</li>
<li>Progress bar will be shown when it takes more than 3 seconds to get results</li>
<li>Support for formatted console text</li>
</ul>
</li>
<li>Function <code>first_isolate</code>:
<ul>
<li>Will now use a column named like “patid” for the patient ID (parameter <code>col_patientid</code>), when this parameter was left blank</li>
<li>Will now use a column named like “key(…)ab” or “key(…)antibiotics” for the key antibiotics (parameter <code>col_keyantibiotics</code>), when this parameter was left blank</li>
<li>Removed parameter <code>output_logical</code>, the function will now always return a logical value</li>
<li>Renamed parameter <code>filter_specimen</code> to <code>specimen_group</code>, although using <code>filter_specimen</code> will still work</li>
</ul>
</li>
<li>A note to the manual pages of the <code>portion</code> functions, that low counts can influence the outcome and that the <code>portion</code> functions may camouflage this, since they only return the portion (albeit being dependent on the <code>minimum</code> parameter)</li>
<li>Function <code>mo_taxonomy</code> now contains the kingdom too</li>
<li>Function <code>first_isolate</code> will now use a column named like “patid” for the patient ID, when this parameter was left blank</li>
<li>Reduce false positives for <code>is.rsi.eligible</code>
</li>
<li>Summaries of class <code>mo</code> will now return the top 3 and the unique count, e.g. using <code><a href="https://www.rdocumentation.org/packages/base/topics/summary">summary(mo)</a></code>
</li>
<li>Small text updates to summaries of class <code>rsi</code> and <code>mic</code>
</li>
<li>Frequency tables (<code>freq</code> function):
<ul>
<li>Header info is now available as a list, with the <code>header</code> function</li>
<li>Added header info for class <code>mo</code> to show unique count of families, genera and species</li>
<li>Now honours the <code>decimal.mark</code> setting, which just like <code>format</code> defaults to <code><a href="https://www.rdocumentation.org/packages/base/topics/options">getOption("OutDec")</a></code>
</li>
<li>The new <code>big.mark</code> parameter will at default be <code>","</code> when <code>decimal.mark = "."</code> and <code>"."</code> otherwise</li>
<li>Fix for header text where all observations are <code>NA</code>
</li>
<li>New parameter <code>droplevels</code> to exclude empty factor levels when input is a factor</li>
<li>Factor levels will be in header when present in input data</li>
</ul>
</li>
<li>Function <code>scale_y_percent</code> now contains the <code>limits</code> parameter</li>
<li>Automatic parameter filling for <code>mdro</code>, <code>key_antibiotics</code> and <code>eucast_rules</code>
</li>
<li>Updated examples for resistance prediction (<code>resistance_predict</code> function)</li>
</ul>
</div>
<div id="other" class="section level4">
<h4 class="hasAnchor">
<a href="#other" class="anchor"></a>Other</h4>
<ul>
<li>Updated licence text to emphasise GPL 2.0 and that this is an R package.</li>
</ul>
</div>
</div>
<div id="amr-0-5-0" class="section level1">
<h1 class="page-header">
<a href="#amr-0-5-0" class="anchor"></a>AMR 0.5.0<small> 2018-11-30 </small>
</h1>
<div id="new-1" class="section level4">
<h4 class="hasAnchor">
<a href="#new-1" class="anchor"></a>New</h4>
<ul>
<li>Repository moved to GitLab: <a href="https://gitlab.com/msberends/AMR" class="uri">https://gitlab.com/msberends/AMR</a>
</li>
<li>Function <code>count_all</code> to get all available isolates (that like all <code>portion_*</code> and <code>count_*</code> functions also supports <code>summarise</code> and <code>group_by</code>), the old <code>n_rsi</code> is now an alias of <code>count_all</code>
</li>
<li>Function <code>get_locale</code> to determine language for language-dependent output for some <code>mo_*</code> functions. This is now the default value for their <code>language</code> parameter, by which the system language will be used at default.</li>
<li>Data sets <code>microorganismsDT</code>, <code>microorganisms.prevDT</code>, <code>microorganisms.unprevDT</code> and <code>microorganisms.oldDT</code> to improve the speed of <code>as.mo</code>. They are for reference only, since they are primarily for internal use of <code>as.mo</code>.</li>
<li>Function <code>read.4D</code> to read from the 4D database of the MMB department of the UMCG</li>
<li>Functions <code>mo_authors</code> and <code>mo_year</code> to get specific values about the scientific reference of a taxonomic entry</li>
</ul>
</div>
<div id="changed-1" class="section level4">
<h4 class="hasAnchor">
<a href="#changed-1" class="anchor"></a>Changed</h4>
<ul>
<li>Functions <code>MDRO</code>, <code>BRMO</code>, <code>MRGN</code> and <code>EUCAST_exceptional_phenotypes</code> were renamed to <code>mdro</code>, <code>brmo</code>, <code>mrgn</code> and <code>eucast_exceptional_phenotypes</code>
</li>
<li>
<code>EUCAST_rules</code> was renamed to <code>eucast_rules</code>, the old function still exists as a deprecated function</li>
<li>Big changes to the <code>eucast_rules</code> function:
<ul>
<li>Now also applies rules from the EUCAST ‘Breakpoint tables for bacteria’, version 8.1, 2018, <a href="http://www.eucast.org/clinical_breakpoints/" class="uri">http://www.eucast.org/clinical_breakpoints/</a> (see Source of the function)</li>
<li>New parameter <code>rules</code> to specify which rules should be applied (expert rules, breakpoints, others or all)</li>
<li>New parameter <code>verbose</code> which can be set to <code>TRUE</code> to get very specific messages about which columns and rows were affected</li>
<li>Better error handling when rules cannot be applied (i.e. new values could not be inserted)</li>
<li>The number of affected values will now only be measured once per row/column combination</li>
<li>Data set <code>septic_patients</code> now reflects these changes</li>
<li>Added parameter <code>pipe</code> for piperacillin (J01CA12), also to the <code>mdro</code> function</li>
<li>Small fixes to EUCAST clinical breakpoint rules</li>
</ul>
</li>
<li>Added column <code>kingdom</code> to the microorganisms data set, and function <code>mo_kingdom</code> to look up values</li>
<li>Tremendous speed improvement for <code>as.mo</code> (and subsequently all <code>mo_*</code> functions), as empty values wil be ignored <em>a priori</em>
</li>
<li>Fewer than 3 characters as input for <code>as.mo</code> will return NA</li>
<li>
<p>Function <code>as.mo</code> (and all <code>mo_*</code> wrappers) now supports genus abbreviations with “species” attached</p>
<div class="sourceCode" id="cb3"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb3-1" data-line-number="1"><span class="kw"><a href="../reference/as.mo.html">as.mo</a></span>(<span class="st">"E. species"</span>) <span class="co"># B_ESCHR</span></a>
<a class="sourceLine" id="cb3-2" data-line-number="2"><span class="kw"><a href="../reference/mo_property.html">mo_fullname</a></span>(<span class="st">"E. spp."</span>) <span class="co"># "Escherichia species"</span></a>
<a class="sourceLine" id="cb3-3" data-line-number="3"><span class="kw"><a href="../reference/as.mo.html">as.mo</a></span>(<span class="st">"S. spp"</span>) <span class="co"># B_STPHY</span></a>
<a class="sourceLine" id="cb3-4" data-line-number="4"><span class="kw"><a href="../reference/mo_property.html">mo_fullname</a></span>(<span class="st">"S. species"</span>) <span class="co"># "Staphylococcus species"</span></a></code></pre></div>
</li>
<li>Added parameter <code>combine_IR</code> (TRUE/FALSE) to functions <code>portion_df</code> and <code>count_df</code>, to indicate that all values of I and R must be merged into one, so the output only consists of S vs. IR (susceptible vs. non-susceptible)</li>
<li>Fix for <code>portion_*(..., as_percent = TRUE)</code> when minimal number of isolates would not be met</li>
<li>Added parameter <code>also_single_tested</code> for <code>portion_*</code> and <code>count_*</code> functions to also include cases where not all antibiotics were tested but at least one of the tested antibiotics includes the target antimicribial interpretation, see <code><a href="../reference/portion.html">?portion</a></code>
</li>
<li>Using <code>portion_*</code> functions now throws a warning when total available isolate is below parameter <code>minimum</code>
</li>
<li>Functions <code>as.mo</code>, <code>as.rsi</code>, <code>as.mic</code>, <code>as.atc</code> and <code>freq</code> will not set package name as attribute anymore</li>
<li>Frequency tables - <code><a href="../reference/freq.html">freq()</a></code>:
<ul>
<li>
<p>Support for grouping variables, test with:</p>
<div class="sourceCode" id="cb4"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb4-1" data-line-number="1">septic_patients <span class="op">%&gt;%</span><span class="st"> </span></a>
<a class="sourceLine" id="cb4-2" data-line-number="2"><span class="st"> </span><span class="kw">group_by</span>(hospital_id) <span class="op">%&gt;%</span><span class="st"> </span></a>
<a class="sourceLine" id="cb4-3" data-line-number="3"><span class="st"> </span><span class="kw"><a href="../reference/freq.html">freq</a></span>(gender)</a></code></pre></div>
</li>
<li>
<p>Support for (un)selecting columns:</p>
<div class="sourceCode" id="cb5"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb5-1" data-line-number="1">septic_patients <span class="op">%&gt;%</span><span class="st"> </span></a>
<a class="sourceLine" id="cb5-2" data-line-number="2"><span class="st"> </span><span class="kw"><a href="../reference/freq.html">freq</a></span>(hospital_id) <span class="op">%&gt;%</span><span class="st"> </span></a>
<a class="sourceLine" id="cb5-3" data-line-number="3"><span class="st"> </span><span class="kw">select</span>(<span class="op">-</span>count, <span class="op">-</span>cum_count) <span class="co"># only get item, percent, cum_percent</span></a></code></pre></div>
</li>
<li>Check for <code><a href="https://www.rdocumentation.org/packages/hms/topics/hms">hms::is.hms</a></code>
</li>
<li>Now prints in markdown at default in non-interactive sessions</li>
<li>No longer adds the factor level column and sorts factors on count again</li>
<li>Support for class <code>difftime</code>
</li>
<li>New parameter <code>na</code>, to choose which character to print for empty values</li>
<li>New parameter <code>header</code> to turn the header info off (default when <code>markdown = TRUE</code>)</li>
<li>New parameter <code>title</code> to manually setbthe title of the frequency table</li>
</ul>
</li>
<li>
<code>first_isolate</code> now tries to find columns to use as input when parameters are left blank</li>
<li>Improvements for MDRO algorithm (function <code>mdro</code>)</li>
<li>Data set <code>septic_patients</code> is now a <code>data.frame</code>, not a tibble anymore</li>
<li>Removed diacritics from all authors (columns <code>microorganisms$ref</code> and <code>microorganisms.old$ref</code>) to comply with CRAN policy to only allow ASCII characters</li>
<li>Fix for <code>mo_property</code> not working properly</li>
<li>Fix for <code>eucast_rules</code> where some Streptococci would become ceftazidime R in EUCAST rule 4.5</li>
<li>Support for named vectors of class <code>mo</code>, useful for <code><a href="../reference/freq.html">top_freq()</a></code>
</li>
<li>
<code>ggplot_rsi</code> and <code>scale_y_percent</code> have <code>breaks</code> parameter</li>
<li>AI improvements for <code>as.mo</code>:
<ul>
<li>
<code>"CRS"</code> -&gt; <em>Stenotrophomonas maltophilia</em>
</li>
<li>
<code>"CRSM"</code> -&gt; <em>Stenotrophomonas maltophilia</em>
</li>
<li>
<code>"MSSA"</code> -&gt; <em>Staphylococcus aureus</em>
</li>
<li>
<code>"MSSE"</code> -&gt; <em>Staphylococcus epidermidis</em>
</li>
</ul>
</li>
<li>Fix for <code>join</code> functions</li>
<li>Speed improvement for <code>is.rsi.eligible</code>, now 15-20 times faster</li>
<li>In <code>g.test</code>, when <code><a href="https://www.rdocumentation.org/packages/base/topics/sum">sum(x)</a></code> is below 1000 or any of the expected values is below 5, Fisher’s Exact Test will be suggested</li>
<li>
<code>ab_name</code> will try to fall back on <code>as.atc</code> when no results are found</li>
<li>Removed the addin to view data sets</li>
<li><p>Percentages will now will rounded more logically (e.g. in <code>freq</code> function)</p></li>
</ul>
</div>
<div id="other-1" class="section level4">
<h4 class="hasAnchor">
<a href="#other-1" class="anchor"></a>Other</h4>
<ul>
<li>New dependency on package <code>crayon</code>, to support formatted text in the console</li>
<li>Dependency <code>tidyr</code> is now mandatory (went to <code>Import</code> field) since <code>portion_df</code> and <code>count_df</code> rely on it</li>
<li>Updated vignettes to comply with README</li>
</ul>
</div>
</div>
<div id="amr-0-4-0" class="section level1">
<h1 class="page-header">
<a href="#amr-0-4-0" class="anchor"></a>AMR 0.4.0<small> 2018-10-01 </small>
</h1>
<div id="new-2" class="section level4">
<h4 class="hasAnchor">
<a href="#new-2" class="anchor"></a>New</h4>
<ul>
<li>The data set <code>microorganisms</code> now contains <strong>all microbial taxonomic data from ITIS</strong> (kingdoms Bacteria, Fungi and Protozoa), the Integrated Taxonomy Information System, available via <a href="https://itis.gov" class="uri">https://itis.gov</a>. The data set now contains more than 18,000 microorganisms with all known bacteria, fungi and protozoa according ITIS with genus, species, subspecies, family, order, class, phylum and subkingdom. The new data set <code>microorganisms.old</code> contains all previously known taxonomic names from those kingdoms.</li>
<li>New functions based on the existing function <code>mo_property</code>:
<ul>
<li>Taxonomic names: <code>mo_phylum</code>, <code>mo_class</code>, <code>mo_order</code>, <code>mo_family</code>, <code>mo_genus</code>, <code>mo_species</code>, <code>mo_subspecies</code>
</li>
<li>Semantic names: <code>mo_fullname</code>, <code>mo_shortname</code>
</li>
<li>Microbial properties: <code>mo_type</code>, <code>mo_gramstain</code>
</li>
<li>Author and year: <code>mo_ref</code>
</li>
</ul>
<p>They also come with support for German, Dutch, French, Italian, Spanish and Portuguese:</p>
<div class="sourceCode" id="cb6"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb6-1" data-line-number="1"><span class="kw"><a href="../reference/mo_property.html">mo_gramstain</a></span>(<span class="st">"E. coli"</span>)</a>
<a class="sourceLine" id="cb6-2" data-line-number="2"><span class="co"># [1] "Gram negative"</span></a>
<a class="sourceLine" id="cb6-3" data-line-number="3"><span class="kw"><a href="../reference/mo_property.html">mo_gramstain</a></span>(<span class="st">"E. coli"</span>, <span class="dt">language =</span> <span class="st">"de"</span>) <span class="co"># German</span></a>
<a class="sourceLine" id="cb6-4" data-line-number="4"><span class="co"># [1] "Gramnegativ"</span></a>
<a class="sourceLine" id="cb6-5" data-line-number="5"><span class="kw"><a href="../reference/mo_property.html">mo_gramstain</a></span>(<span class="st">"E. coli"</span>, <span class="dt">language =</span> <span class="st">"es"</span>) <span class="co"># Spanish</span></a>
<a class="sourceLine" id="cb6-6" data-line-number="6"><span class="co"># [1] "Gram negativo"</span></a>
<a class="sourceLine" id="cb6-7" data-line-number="7"><span class="kw"><a href="../reference/mo_property.html">mo_fullname</a></span>(<span class="st">"S. group A"</span>, <span class="dt">language =</span> <span class="st">"pt"</span>) <span class="co"># Portuguese</span></a>
<a class="sourceLine" id="cb6-8" data-line-number="8"><span class="co"># [1] "Streptococcus grupo A"</span></a></code></pre></div>
<p>Furthermore, former taxonomic names will give a note about the current taxonomic name:</p>
<div class="sourceCode" id="cb7"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb7-1" data-line-number="1"><span class="kw"><a href="../reference/mo_property.html">mo_gramstain</a></span>(<span class="st">"Esc blattae"</span>)</a>
<a class="sourceLine" id="cb7-2" data-line-number="2"><span class="co"># Note: 'Escherichia blattae' (Burgess et al., 1973) was renamed 'Shimwellia blattae' (Priest and Barker, 2010)</span></a>
<a class="sourceLine" id="cb7-3" data-line-number="3"><span class="co"># [1] "Gram negative"</span></a></code></pre></div>
</li>
<li>Functions <code>count_R</code>, <code>count_IR</code>, <code>count_I</code>, <code>count_SI</code> and <code>count_S</code> to selectively count resistant or susceptible isolates
<ul>
<li>Extra function <code>count_df</code> (which works like <code>portion_df</code>) to get all counts of S, I and R of a data set with antibiotic columns, with support for grouped variables</li>
</ul>
</li>
<li>Function <code>is.rsi.eligible</code> to check for columns that have valid antimicrobial results, but do not have the <code>rsi</code> class yet. Transform the columns of your raw data with: <code>data %&gt;% mutate_if(is.rsi.eligible, as.rsi)</code>
</li>
<li>
<p>Functions <code>as.mo</code> and <code>is.mo</code> as replacements for <code>as.bactid</code> and <code>is.bactid</code> (since the <code>microoganisms</code> data set not only contains bacteria). These last two functions are deprecated and will be removed in a future release. The <code>as.mo</code> function determines microbial IDs using Artificial Intelligence (AI):</p>
<div class="sourceCode" id="cb8"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb8-1" data-line-number="1"><span class="kw"><a href="../reference/as.mo.html">as.mo</a></span>(<span class="st">"E. coli"</span>)</a>
<a class="sourceLine" id="cb8-2" data-line-number="2"><span class="co"># [1] B_ESCHR_COL</span></a>
<a class="sourceLine" id="cb8-3" data-line-number="3"><span class="kw"><a href="../reference/as.mo.html">as.mo</a></span>(<span class="st">"MRSA"</span>)</a>
<a class="sourceLine" id="cb8-4" data-line-number="4"><span class="co"># [1] B_STPHY_AUR</span></a>
<a class="sourceLine" id="cb8-5" data-line-number="5"><span class="kw"><a href="../reference/as.mo.html">as.mo</a></span>(<span class="st">"S group A"</span>)</a>
<a class="sourceLine" id="cb8-6" data-line-number="6"><span class="co"># [1] B_STRPTC_GRA</span></a></code></pre></div>
<p>And with great speed too - on a quite regular Linux server from 2007 it takes us less than 0.02 seconds to transform 25,000 items:</p>
<div class="sourceCode" id="cb9"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb9-1" data-line-number="1">thousands_of_E_colis &lt;-<span class="st"> </span><span class="kw"><a href="https://www.rdocumentation.org/packages/base/topics/rep">rep</a></span>(<span class="st">"E. coli"</span>, <span class="dv">25000</span>)</a>
<a class="sourceLine" id="cb9-2" data-line-number="2">microbenchmark<span class="op">::</span><span class="kw"><a href="https://www.rdocumentation.org/packages/microbenchmark/topics/microbenchmark">microbenchmark</a></span>(<span class="kw"><a href="../reference/as.mo.html">as.mo</a></span>(thousands_of_E_colis), <span class="dt">unit =</span> <span class="st">"s"</span>)</a>
<a class="sourceLine" id="cb9-3" data-line-number="3"><span class="co"># Unit: seconds</span></a>
<a class="sourceLine" id="cb9-4" data-line-number="4"><span class="co"># min median max neval</span></a>
<a class="sourceLine" id="cb9-5" data-line-number="5"><span class="co"># 0.01817717 0.01843957 0.03878077 100</span></a></code></pre></div>
</li>
<li>Added parameter <code>reference_df</code> for <code>as.mo</code>, so users can supply their own microbial IDs, name or codes as a reference table</li>
<li>Renamed all previous references to <code>bactid</code> to <code>mo</code>, like:
<ul>
<li>Column names inputs of <code>EUCAST_rules</code>, <code>first_isolate</code> and <code>key_antibiotics</code>
</li>
<li>Column names of datasets <code>microorganisms</code> and <code>septic_patients</code>
</li>
<li>All old syntaxes will still work with this version, but will throw warnings</li>
</ul>
</li>
<li>Function <code>labels_rsi_count</code> to print datalabels on a RSI <code>ggplot2</code> model</li>
<li><p>Functions <code>as.atc</code> and <code>is.atc</code> to transform/look up antibiotic ATC codes as defined by the WHO. The existing function <code>guess_atc</code> is now an alias of <code>as.atc</code>.</p></li>
<li>Function <code>ab_property</code> and its aliases: <code>ab_name</code>, <code>ab_tradenames</code>, <code>ab_certe</code>, <code>ab_umcg</code> and <code>ab_trivial_nl</code>
</li>
<li>Introduction to AMR as a vignette</li>
<li>Removed clipboard functions as it violated the CRAN policy</li>
<li><p>Renamed <code>septic_patients$sex</code> to <code>septic_patients$gender</code></p></li>
</ul>
</div>
<div id="changed-2" class="section level4">
<h4 class="hasAnchor">
<a href="#changed-2" class="anchor"></a>Changed</h4>
<ul>
<li>Added three antimicrobial agents to the <code>antibiotics</code> data set: Terbinafine (D01BA02), Rifaximin (A07AA11) and Isoconazole (D01AC05)</li>
<li>
<p>Added 163 trade names to the <code>antibiotics</code> data set, it now contains 298 different trade names in total, e.g.:</p>
<div class="sourceCode" id="cb10"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb10-1" data-line-number="1"><span class="kw"><a href="../reference/ab_property.html">ab_official</a></span>(<span class="st">"Bactroban"</span>)</a>
<a class="sourceLine" id="cb10-2" data-line-number="2"><span class="co"># [1] "Mupirocin"</span></a>
<a class="sourceLine" id="cb10-3" data-line-number="3"><span class="kw"><a href="../reference/ab_property.html">ab_name</a></span>(<span class="kw"><a href="https://www.rdocumentation.org/packages/base/topics/c">c</a></span>(<span class="st">"Bactroban"</span>, <span class="st">"Amoxil"</span>, <span class="st">"Zithromax"</span>, <span class="st">"Floxapen"</span>))</a>
<a class="sourceLine" id="cb10-4" data-line-number="4"><span class="co"># [1] "Mupirocin" "Amoxicillin" "Azithromycin" "Flucloxacillin"</span></a>
<a class="sourceLine" id="cb10-5" data-line-number="5"><span class="kw"><a href="../reference/ab_property.html">ab_atc</a></span>(<span class="kw"><a href="https://www.rdocumentation.org/packages/base/topics/c">c</a></span>(<span class="st">"Bactroban"</span>, <span class="st">"Amoxil"</span>, <span class="st">"Zithromax"</span>, <span class="st">"Floxapen"</span>))</a>
<a class="sourceLine" id="cb10-6" data-line-number="6"><span class="co"># [1] "R01AX06" "J01CA04" "J01FA10" "J01CF05"</span></a></code></pre></div>
</li>
<li>For <code>first_isolate</code>, rows will be ignored when there’s no species available</li>
<li>Function <code>ratio</code> is now deprecated and will be removed in a future release, as it is not really the scope of this package</li>
<li>Fix for <code>as.mic</code> for values ending in zeroes after a real number</li>
<li>Small fix where <em>B. fragilis</em> would not be found in the <code>microorganisms.umcg</code> data set</li>
<li>Added <code>prevalence</code> column to the <code>microorganisms</code> data set</li>
<li>Added parameters <code>minimum</code> and <code>as_percent</code> to <code>portion_df</code>
</li>
<li>
<p>Support for quasiquotation in the functions series <code>count_*</code> and <code>portions_*</code>, and <code>n_rsi</code>. This allows to check for more than 2 vectors or columns.</p>
<div class="sourceCode" id="cb11"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb11-1" data-line-number="1">septic_patients <span class="op">%&gt;%</span><span class="st"> </span><span class="kw">select</span>(amox, cipr) <span class="op">%&gt;%</span><span class="st"> </span><span class="kw"><a href="../reference/count.html">count_IR</a></span>()</a>
<a class="sourceLine" id="cb11-2" data-line-number="2"><span class="co"># which is the same as:</span></a>
<a class="sourceLine" id="cb11-3" data-line-number="3">septic_patients <span class="op">%&gt;%</span><span class="st"> </span><span class="kw"><a href="../reference/count.html">count_IR</a></span>(amox, cipr)</a>
<a class="sourceLine" id="cb11-4" data-line-number="4"></a>
<a class="sourceLine" id="cb11-5" data-line-number="5">septic_patients <span class="op">%&gt;%</span><span class="st"> </span><span class="kw"><a href="../reference/portion.html">portion_S</a></span>(amcl)</a>
<a class="sourceLine" id="cb11-6" data-line-number="6">septic_patients <span class="op">%&gt;%</span><span class="st"> </span><span class="kw"><a href="../reference/portion.html">portion_S</a></span>(amcl, gent)</a>
<a class="sourceLine" id="cb11-7" data-line-number="7">septic_patients <span class="op">%&gt;%</span><span class="st"> </span><span class="kw"><a href="../reference/portion.html">portion_S</a></span>(amcl, gent, pita)</a></code></pre></div>
</li>
<li>Edited <code>ggplot_rsi</code> and <code>geom_rsi</code> so they can cope with <code>count_df</code>. The new <code>fun</code> parameter has value <code>portion_df</code> at default, but can be set to <code>count_df</code>.</li>
<li>Fix for <code>ggplot_rsi</code> when the <code>ggplot2</code> package was not loaded</li>
<li>Added datalabels function <code>labels_rsi_count</code> to <code>ggplot_rsi</code>
</li>
<li>Added possibility to set any parameter to <code>geom_rsi</code> (and <code>ggplot_rsi</code>) so you can set your own preferences</li>
<li>Fix for joins, where predefined suffices would not be honoured</li>
<li>Added parameter <code>quote</code> to the <code>freq</code> function</li>
<li>Added generic function <code>diff</code> for frequency tables</li>
<li>Added longest en shortest character length in the frequency table (<code>freq</code>) header of class <code>character</code>
</li>
<li>
<p>Support for types (classes) list and matrix for <code>freq</code></p>
<div class="sourceCode" id="cb12"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb12-1" data-line-number="1">my_matrix =<span class="st"> </span><span class="kw"><a href="https://www.rdocumentation.org/packages/base/topics/with">with</a></span>(septic_patients, <span class="kw"><a href="https://www.rdocumentation.org/packages/base/topics/matrix">matrix</a></span>(<span class="kw"><a href="https://www.rdocumentation.org/packages/base/topics/c">c</a></span>(age, gender), <span class="dt">ncol =</span> <span class="dv">2</span>))</a>
<a class="sourceLine" id="cb12-2" data-line-number="2"><span class="kw"><a href="../reference/freq.html">freq</a></span>(my_matrix)</a></code></pre></div>
<p>For lists, subsetting is possible:</p>
<div class="sourceCode" id="cb13"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb13-1" data-line-number="1">my_list =<span class="st"> </span><span class="kw"><a href="https://www.rdocumentation.org/packages/base/topics/list">list</a></span>(<span class="dt">age =</span> septic_patients<span class="op">$</span>age, <span class="dt">gender =</span> septic_patients<span class="op">$</span>gender)</a>
<a class="sourceLine" id="cb13-2" data-line-number="2">my_list <span class="op">%&gt;%</span><span class="st"> </span><span class="kw"><a href="../reference/freq.html">freq</a></span>(age)</a>
<a class="sourceLine" id="cb13-3" data-line-number="3">my_list <span class="op">%&gt;%</span><span class="st"> </span><span class="kw"><a href="../reference/freq.html">freq</a></span>(gender)</a></code></pre></div>
</li>
</ul>
</div>
<div id="other-2" class="section level4">
<h4 class="hasAnchor">
<a href="#other-2" class="anchor"></a>Other</h4>
<ul>
<li>More unit tests to ensure better integrity of functions</li>
</ul>
</div>
</div>
<div id="amr-0-3-0" class="section level1">
<h1 class="page-header">
<a href="#amr-0-3-0" class="anchor"></a>AMR 0.3.0<small> 2018-08-14 </small>
</h1>
<div id="new-3" class="section level4">
<h4 class="hasAnchor">
<a href="#new-3" class="anchor"></a>New</h4>
<ul>
<li>
<strong>BREAKING</strong>: <code>rsi_df</code> was removed in favour of new functions <code>portion_R</code>, <code>portion_IR</code>, <code>portion_I</code>, <code>portion_SI</code> and <code>portion_S</code> to selectively calculate resistance or susceptibility. These functions are 20 to 30 times faster than the old <code>rsi</code> function. The old function still works, but is deprecated.
<ul>
<li>New function <code>portion_df</code> to get all portions of S, I and R of a data set with antibiotic columns, with support for grouped variables</li>
</ul>
</li>
<li>
<strong>BREAKING</strong>: the methodology for determining first weighted isolates was changed. The antibiotics that are compared between isolates (call <em>key antibiotics</em>) to include more first isolates (afterwards called first <em>weighted</em> isolates) are now as follows:
<ul>
<li>Universal: amoxicillin, amoxicillin/clavlanic acid, cefuroxime, piperacillin/tazobactam, ciprofloxacin, trimethoprim/sulfamethoxazole</li>
<li>Gram-positive: vancomycin, teicoplanin, tetracycline, erythromycin, oxacillin, rifampicin</li>
<li>Gram-negative: gentamicin, tobramycin, colistin, cefotaxime, ceftazidime, meropenem</li>
</ul>
</li>
<li>Support for <code>ggplot2</code>
<ul>
<li>New functions <code>geom_rsi</code>, <code>facet_rsi</code>, <code>scale_y_percent</code>, <code>scale_rsi_colours</code> and <code>theme_rsi</code>
</li>
<li>New wrapper function <code>ggplot_rsi</code> to apply all above functions on a data set:
<ul>
<li>
<code>septic_patients %&gt;% select(tobr, gent) %&gt;% ggplot_rsi</code> will show portions of S, I and R immediately in a pretty plot</li>
<li>Support for grouped variables, see <code><a href="../reference/ggplot_rsi.html">?ggplot_rsi</a></code>
</li>
</ul>
</li>
</ul>
</li>
<li>Determining bacterial ID:
<ul>
<li>New functions <code>as.bactid</code> and <code>is.bactid</code> to transform/ look up microbial ID’s.</li>
<li>The existing function <code>guess_bactid</code> is now an alias of <code>as.bactid</code>
</li>
<li>New Becker classification for <em>Staphylococcus</em> to categorise them into Coagulase Negative <em>Staphylococci</em> (CoNS) and Coagulase Positve <em>Staphylococci</em> (CoPS)</li>
<li>New Lancefield classification for <em>Streptococcus</em> to categorise them into Lancefield groups</li>
</ul>
</li>
<li>For convience, new descriptive statistical functions <code>kurtosis</code> and <code>skewness</code> that are lacking in base R - they are generic functions and have support for vectors, data.frames and matrices</li>
<li>Function <code>g.test</code> to perform the Χ<sup>2</sup> distributed <a href="https://en.wikipedia.org/wiki/G-test"><em>G</em>-test</a>, which use is the same as <code>chisq.test</code>
</li>
<li>
<del>Function <code>ratio</code> to transform a vector of values to a preset ratio</del>
<ul>
<li><del>For example: <code><a href="../reference/AMR-deprecated.html">ratio(c(10, 500, 10), ratio = "1:2:1")</a></code> would return <code>130, 260, 130</code></del></li>
</ul>
</li>
<li>Support for Addins menu in RStudio to quickly insert <code>%in%</code> or <code>%like%</code> (and give them keyboard shortcuts), or to view the datasets that come with this package</li>
<li>Function <code>p.symbol</code> to transform p values to their related symbols: <code>0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1</code>
</li>
<li>Functions <code>clipboard_import</code> and <code>clipboard_export</code> as helper functions to quickly copy and paste from/to software like Excel and SPSS. These functions use the <code>clipr</code> package, but are a little altered to also support headless Linux servers (so you can use it in RStudio Server)</li>
<li>New for frequency tables (function <code>freq</code>):
<ul>
<li>A vignette to explain its usage</li>
<li>Support for <code>rsi</code> (antimicrobial resistance) to use as input</li>
<li>Support for <code>table</code> to use as input: <code><a href="../reference/freq.html">freq(table(x, y))</a></code>
</li>
<li>Support for existing functions <code>hist</code> and <code>plot</code> to use a frequency table as input: <code><a href="https://www.rdocumentation.org/packages/graphics/topics/hist">hist(freq(df$age))</a></code>
</li>
<li>Support for <code>as.vector</code>, <code>as.data.frame</code>, <code>as_tibble</code> and <code>format</code>
</li>
<li>Support for quasiquotation: <code><a href="../reference/freq.html">freq(mydata, mycolumn)</a></code> is the same as <code>mydata %&gt;% freq(mycolumn)</code>
</li>
<li>Function <code>top_freq</code> function to return the top/below <em>n</em> items as vector</li>
<li>Header of frequency tables now also show Mean Absolute Deviaton (MAD) and Interquartile Range (IQR)</li>
<li>Possibility to globally set the default for the amount of items to print, with <code><a href="https://www.rdocumentation.org/packages/base/topics/options">options(max.print.freq = n)</a></code> where <em>n</em> is your preset value</li>
</ul>
</li>
</ul>
</div>
<div id="changed-3" class="section level4">
<h4 class="hasAnchor">
<a href="#changed-3" class="anchor"></a>Changed</h4>
<ul>
<li>Improvements for forecasting with <code>resistance_predict</code> and added more examples</li>
<li>More antibiotics added as parameters for EUCAST rules</li>
<li>Updated version of the <code>septic_patients</code> data set to better reflect the reality</li>
<li>Pretty printing for tibbles removed as it is not really the scope of this package</li>
<li>Printing of <code>mic</code> and <code>rsi</code> classes now returns all values - use <code>freq</code> to check distributions</li>
<li>Improved speed of key antibiotics comparison for determining first isolates</li>
<li>Column names for the <code>key_antibiotics</code> function are now generic: 6 for broadspectrum ABs, 6 for Gram-positive specific and 6 for Gram-negative specific ABs</li>
<li>Speed improvement for the <code>abname</code> function</li>
<li>
<code>%like%</code> now supports multiple patterns</li>
<li>Frequency tables are now actual <code>data.frame</code>s with altered console printing to make it look like a frequency table. Because of this, the parameter <code>toConsole</code> is not longer needed.</li>
<li>Fix for <code>freq</code> where the class of an item would be lost</li>
<li>Small translational improvements to the <code>septic_patients</code> dataset and the column <code>bactid</code> now has the new class <code>"bactid"</code>
</li>
<li>Small improvements to the <code>microorganisms</code> dataset (especially for <em>Salmonella</em>) and the column <code>bactid</code> now has the new class <code>"bactid"</code>
</li>
<li>Combined MIC/RSI values will now be coerced by the <code>rsi</code> and <code>mic</code> functions:
<ul>
<li>
<code><a href="../reference/as.rsi.html">as.rsi("&lt;=0.002; S")</a></code> will return <code>S</code>
</li>
<li>
<code><a href="../reference/as.mic.html">as.mic("&lt;=0.002; S")</a></code> will return <code>&lt;=0.002</code>
</li>
</ul>
</li>
<li>Now possible to coerce MIC values with a space between operator and value, i.e. <code><a href="../reference/as.mic.html">as.mic("&lt;= 0.002")</a></code> now works</li>
<li>Classes <code>rsi</code> and <code>mic</code> do not add the attribute <code>package.version</code> anymore</li>
<li>Added <code>"groups"</code> option for <code><a href="../reference/atc_property.html">atc_property(..., property)</a></code>. It will return a vector of the ATC hierarchy as defined by the <a href="https://www.whocc.no/atc/structure_and_principles/">WHO</a>. The new function <code>atc_groups</code> is a convenient wrapper around this.</li>
<li>Build-in host check for <code>atc_property</code> as it requires the host set by <code>url</code> to be responsive</li>
<li>Improved <code>first_isolate</code> algorithm to exclude isolates where bacteria ID or genus is unavailable</li>
<li>Fix for warning <em>hybrid evaluation forced for row_number</em> (<a href="https://github.com/tidyverse/dplyr/commit/924b62"><code>924b62</code></a>) from the <code>dplyr</code> package v0.7.5 and above</li>
<li>Support for empty values and for 1 or 2 columns as input for <code>guess_bactid</code> (now called <code>as.bactid</code>)
<ul>
<li>So <code>yourdata %&gt;% select(genus, species) %&gt;% as.bactid()</code> now also works</li>
</ul>
</li>
<li>Other small fixes</li>
</ul>
</div>
<div id="other-3" class="section level4">
<h4 class="hasAnchor">
<a href="#other-3" class="anchor"></a>Other</h4>
<ul>
<li>Added integration tests (check if everything works as expected) for all releases of R 3.1 and higher
<ul>
<li>Linux and macOS: <a href="https://travis-ci.org/msberends/AMR" class="uri">https://travis-ci.org/msberends/AMR</a>
</li>
<li>Windows: <a href="https://ci.appveyor.com/project/msberends/amr" class="uri">https://ci.appveyor.com/project/msberends/amr</a>
</li>
</ul>
</li>
<li>Added thesis advisors to DESCRIPTION file</li>
</ul>
</div>
</div>
<div id="amr-0-2-0" class="section level1">
<h1 class="page-header">
<a href="#amr-0-2-0" class="anchor"></a>AMR 0.2.0<small> 2018-05-03 </small>
</h1>
<div id="new-4" class="section level4">
<h4 class="hasAnchor">
<a href="#new-4" class="anchor"></a>New</h4>
<ul>
<li>Full support for Windows, Linux and macOS</li>
<li>Full support for old R versions, only R-3.0.0 (April 2013) or later is needed (needed packages may have other dependencies)</li>
<li>Function <code>n_rsi</code> to count cases where antibiotic test results were available, to be used in conjunction with <code><a href="http://dplyr.tidyverse.org/reference/summarise.html">dplyr::summarise</a></code>, see ?rsi</li>
<li>Function <code>guess_bactid</code> to <strong>determine the ID</strong> of a microorganism based on genus/species or known abbreviations like MRSA</li>
<li>Function <code>guess_atc</code> to <strong>determine the ATC</strong> of an antibiotic based on name, trade name, or known abbreviations</li>
<li>Function <code>freq</code> to create <strong>frequency tables</strong>, with additional info in a header</li>
<li>Function <code>MDRO</code> to <strong>determine Multi Drug Resistant Organisms (MDRO)</strong> with support for country-specific guidelines.
<ul>
<li>Suggest your own via <a href="https://github.com/msberends/AMR/issues/new?title=New%20guideline%20for%20MDRO&amp;body=%3C--%20Please%20add%20your%20country%20code,%20guideline%20name,%20version%20and%20source%20below%20and%20remove%20this%20line--%3E">https://github.com/msberends/AMR/issues/new</a>
</li>
<li>
<a href="http://www.eucast.org/expert_rules_and_intrinsic_resistance">Exceptional resistances defined by EUCAST</a> are also supported instead of countries alone</li>
<li>Functions <code>BRMO</code> and <code>MRGN</code> are wrappers for Dutch and German guidelines, respectively</li>
</ul>
</li>
<li>New algorithm to determine weighted isolates, can now be <code>"points"</code> or <code>"keyantibiotics"</code>, see <code><a href="../reference/first_isolate.html">?first_isolate</a></code>
</li>
<li>New print format for <code>tibble</code>s and <code>data.table</code>s</li>
</ul>
</div>
<div id="changed-4" class="section level4">
<h4 class="hasAnchor">
<a href="#changed-4" class="anchor"></a>Changed</h4>
<ul>
<li>Fixed <code>rsi</code> class for vectors that contain only invalid antimicrobial interpretations</li>
<li>Renamed dataset <code>ablist</code> to <code>antibiotics</code>
</li>
<li>Renamed dataset <code>bactlist</code> to <code>microorganisms</code>
</li>
<li>Added common abbreviations and trade names to the <code>antibiotics</code> dataset</li>
<li>Added more microorganisms to the <code>microorganisms</code> dataset</li>
<li>Added analysis examples on help page of dataset <code>septic_patients</code>
</li>
<li>Added support for character vector in <code>join</code> functions</li>
<li>Added warnings when a join results in more rows after than before the join</li>
<li>Altered <code>%like%</code> to make it case insensitive</li>
<li>For parameters of functions <code>first_isolate</code> and <code>EUCAST_rules</code> column names are now case-insensitive</li>
<li>Functions <code>as.rsi</code> and <code>as.mic</code> now add the package name and version as attributes</li>
</ul>
</div>
<div id="other-4" class="section level4">
<h4 class="hasAnchor">
<a href="#other-4" class="anchor"></a>Other</h4>
<ul>
<li>Expanded <code>README.md</code> with more examples</li>
<li>Added <a href="https://orcid.org">ORCID</a> of authors to DESCRIPTION file</li>
<li>Added unit testing with the <code>testthat</code> package</li>
<li>Added build tests for Linux and macOS using Travis CI (<a href="https://travis-ci.org/msberends/AMR" class="uri">https://travis-ci.org/msberends/AMR</a>)</li>
<li>Added line coverage checking using CodeCov (<a href="https://codecov.io/gh/msberends/AMR/tree/master/R" class="uri">https://codecov.io/gh/msberends/AMR/tree/master/R</a>)</li>
</ul>
</div>
</div>
<div id="amr-0-1-1" class="section level1">
<h1 class="page-header">
<a href="#amr-0-1-1" class="anchor"></a>AMR 0.1.1<small> 2018-03-14 </small>
</h1>
<ul>
<li>
<code>EUCAST_rules</code> applies for amoxicillin even if ampicillin is missing</li>
<li>Edited column names to comply with GLIMS, the laboratory information system</li>
<li>Added more valid MIC values</li>
<li>Renamed ‘Daily Defined Dose’ to ‘Defined Daily Dose’</li>
<li>Added barplots for <code>rsi</code> and <code>mic</code> classes</li>
</ul>
</div>
<div id="amr-0-1-0" class="section level1">
<h1 class="page-header">
<a href="#amr-0-1-0" class="anchor"></a>AMR 0.1.0<small> 2018-02-22 </small>
</h1>
<ul>
<li>First submission to CRAN.</li>
</ul>
</div>
</div>
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<li><a href="#amr-0-4-0">0.4.0</a></li>
<li><a href="#amr-0-3-0">0.3.0</a></li>
<li><a href="#amr-0-2-0">0.2.0</a></li>
<li><a href="#amr-0-1-1">0.1.1</a></li>
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@@ -0,0 +1,10 @@
pandoc: 2.3.1
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AMR: AMR.html
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105
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@@ -71,37 +88,64 @@
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@@ -147,6 +191,23 @@
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@@ -62,8 +79,8 @@
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@@ -166,7 +210,14 @@
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='fu'>ab_atc</span>(<span class='st'>"amcl"</span>) <span class='co'># J01CR02</span></div><div class='output co'>#&gt; [1] "J01CR02"</div><div class='input'><span class='fu'>ab_name</span>(<span class='st'>"amcl"</span>) <span class='co'># Amoxicillin and beta-lactamase inhibitor</span></div><div class='output co'>#&gt; [1] "Amoxicillin and beta-lactamase inhibitor"</div><div class='input'><span class='fu'>ab_name</span>(<span class='st'>"amcl"</span>, <span class='st'>"nl"</span>) <span class='co'># Amoxicilline met enzymremmer</span></div><div class='output co'>#&gt; [1] "Amoxicilline met enzymremmer"</div><div class='input'><span class='fu'>ab_trivial_nl</span>(<span class='st'>"amcl"</span>) <span class='co'># Amoxicilline/clavulaanzuur</span></div><div class='output co'>#&gt; [1] "Amoxicilline/clavulaanzuur"</div><div class='input'><span class='fu'>ab_certe</span>(<span class='st'>"amcl"</span>) <span class='co'># amcl</span></div><div class='output co'>#&gt; [1] "amcl"</div><div class='input'><span class='fu'>ab_umcg</span>(<span class='st'>"amcl"</span>) <span class='co'># AMCL</span></div><div class='output co'>#&gt; [1] "AMCL"</div></pre>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='fu'>ab_atc</span>(<span class='st'>"amcl"</span>) <span class='co'># J01CR02</span>
<span class='fu'>ab_name</span>(<span class='st'>"amcl"</span>) <span class='co'># Amoxicillin and beta-lactamase inhibitor</span>
<span class='fu'>ab_name</span>(<span class='st'>"amcl"</span>, <span class='st'>"nl"</span>) <span class='co'># Amoxicilline met enzymremmer</span>
<span class='fu'>ab_trivial_nl</span>(<span class='st'>"amcl"</span>) <span class='co'># Amoxicilline/clavulaanzuur</span>
<span class='fu'>ab_certe</span>(<span class='st'>"amcl"</span>) <span class='co'># amcl</span>
<span class='fu'>ab_umcg</span>(<span class='st'>"amcl"</span>) <span class='co'># AMCL</span>
<span class='co'># }</span></pre>
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@@ -185,7 +236,7 @@
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133
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@@ -6,13 +6,20 @@
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@@ -157,28 +201,36 @@
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='fu'>abname</span>(<span class='st'>"AMCL"</span>)</div><div class='output co'>#&gt; [1] "Amoxicillin and beta-lactamase inhibitor"</div><div class='input'><span class='co'># "Amoxicillin and beta-lactamase inhibitor"</span>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='fu'>abname</span>(<span class='st'>"AMCL"</span>)
<span class='co'># "Amoxicillin and beta-lactamase inhibitor"</span>
<span class='co'># It is quite flexible at default (having `from = "guess"`)</span>
<span class='fu'>abname</span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"amox"</span>, <span class='st'>"J01CA04"</span>, <span class='st'>"Trimox"</span>, <span class='st'>"dispermox"</span>, <span class='st'>"Amoxil"</span>))</div><div class='output co'>#&gt; [1] "Amoxicillin" "Amoxicillin" "Amoxicillin" "Amoxicillin" "Amoxicillin"</div><div class='input'><span class='co'># "Amoxicillin" "Amoxicillin" "Amoxicillin" "Amoxicillin" "Amoxicillin"</span>
<span class='fu'>abname</span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"amox"</span>, <span class='st'>"J01CA04"</span>, <span class='st'>"Trimox"</span>, <span class='st'>"dispermox"</span>, <span class='st'>"Amoxil"</span>))
<span class='co'># "Amoxicillin" "Amoxicillin" "Amoxicillin" "Amoxicillin" "Amoxicillin"</span>
<span class='co'># Multiple antibiotics can be combined with "+".</span>
<span class='co'># The second antibiotic will be set to lower case when `tolower` was not set:</span>
<span class='fu'>abname</span>(<span class='st'>"AMCL+GENT"</span>, <span class='kw'>textbetween</span> <span class='kw'>=</span> <span class='st'>"/"</span>)</div><div class='output co'>#&gt; [1] "Amoxicillin and beta-lactamase inhibitor/gentamicin"</div><div class='input'><span class='co'># "amoxicillin and enzyme inhibitor/gentamicin"</span>
<span class='fu'>abname</span>(<span class='st'>"AMCL+GENT"</span>, <span class='kw'>textbetween</span> <span class='kw'>=</span> <span class='st'>"/"</span>)
<span class='co'># "amoxicillin and enzyme inhibitor/gentamicin"</span>
<span class='fu'>abname</span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"AMCL"</span>, <span class='st'>"GENT"</span>))</div><div class='output co'>#&gt; [1] "Amoxicillin and beta-lactamase inhibitor"
#&gt; [2] "Gentamicin" </div><div class='input'><span class='co'># "Amoxicillin and beta-lactamase inhibitor" "Gentamicin"</span>
<span class='fu'>abname</span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"AMCL"</span>, <span class='st'>"GENT"</span>))
<span class='co'># "Amoxicillin and beta-lactamase inhibitor" "Gentamicin"</span>
<span class='fu'>abname</span>(<span class='st'>"AMCL"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"trivial_nl"</span>)</div><div class='output co'>#&gt; [1] "Amoxicilline/clavulaanzuur"</div><div class='input'><span class='co'># "Amoxicilline/clavulaanzuur"</span>
<span class='fu'>abname</span>(<span class='st'>"AMCL"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"trivial_nl"</span>)
<span class='co'># "Amoxicilline/clavulaanzuur"</span>
<span class='fu'>abname</span>(<span class='st'>"AMCL"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"atc"</span>)</div><div class='output co'>#&gt; [1] "J01CR02"</div><div class='input'><span class='co'># "J01CR02"</span>
<span class='fu'>abname</span>(<span class='st'>"AMCL"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"atc"</span>)
<span class='co'># "J01CR02"</span>
<span class='co'># specific codes for University Medical Center Groningen (UMCG):</span>
<span class='fu'>abname</span>(<span class='st'>"J01CR02"</span>, <span class='kw'>from</span> <span class='kw'>=</span> <span class='st'>"atc"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"umcg"</span>)</div><div class='output co'>#&gt; [1] "AMCL"</div><div class='input'><span class='co'># "AMCL"</span>
<span class='fu'>abname</span>(<span class='st'>"J01CR02"</span>, <span class='kw'>from</span> <span class='kw'>=</span> <span class='st'>"atc"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"umcg"</span>)
<span class='co'># "AMCL"</span>
<span class='co'># specific codes for Certe:</span>
<span class='fu'>abname</span>(<span class='st'>"J01CR02"</span>, <span class='kw'>from</span> <span class='kw'>=</span> <span class='st'>"atc"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"certe"</span>)</div><div class='output co'>#&gt; [1] "amcl"</div><div class='input'># "amcl"
</div></pre>
<span class='fu'>abname</span>(<span class='st'>"J01CR02"</span>, <span class='kw'>from</span> <span class='kw'>=</span> <span class='st'>"atc"</span>, <span class='kw'>to</span> <span class='kw'>=</span> <span class='st'>"certe"</span>)
<span class='co'># "amcl"</span>
<span class='co'># }</span></pre>
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@@ -197,7 +249,7 @@
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<p>Developed by <a href='https://www.rug.nl/staff/m.s.berends/'>Matthijs S. Berends</a>, <a href='https://www.rug.nl/staff/c.f.luz/'>Christian F. Luz</a>, <a href='https://www.rug.nl/staff/c.glasner/'>Corinna Glasner</a>, <a href='https://www.rug.nl/staff/a.w.friedrich/'>Alex W. Friedrich</a>, <a href='https://www.rug.nl/staff/b.sinha/'>Bhanu N. M. Sinha</a>.</p>
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105
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@@ -6,13 +6,20 @@
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@@ -62,8 +79,8 @@
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@@ -161,43 +205,39 @@
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='no'>ages</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='fl'>3</span>, <span class='fl'>8</span>, <span class='fl'>16</span>, <span class='fl'>54</span>, <span class='fl'>31</span>, <span class='fl'>76</span>, <span class='fl'>101</span>, <span class='fl'>43</span>, <span class='fl'>21</span>)
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='no'>ages</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='fl'>3</span>, <span class='fl'>8</span>, <span class='fl'>16</span>, <span class='fl'>54</span>, <span class='fl'>31</span>, <span class='fl'>76</span>, <span class='fl'>101</span>, <span class='fl'>43</span>, <span class='fl'>21</span>)
<span class='co'># split into 0-49 and 50+</span>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='fl'>50</span>)</div><div class='output co'>#&gt; [1] 0-49 0-49 0-49 50+ 0-49 50+ 50+ 0-49 0-49
#&gt; Levels: 0-49 &lt; 50+</div><div class='input'>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='fl'>50</span>)
<span class='co'># split into 0-19, 20-49 and 50+</span>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='fl'>20</span>, <span class='fl'>50</span>))</div><div class='output co'>#&gt; [1] 0-19 0-19 0-19 50+ 20-49 50+ 50+ 20-49 20-49
#&gt; Levels: 0-19 &lt; 20-49 &lt; 50+</div><div class='input'>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='fl'>20</span>, <span class='fl'>50</span>))
<span class='co'># split into groups of ten years</span>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='fl'>1</span>:<span class='fl'>10</span> * <span class='fl'>10</span>)</div><div class='output co'>#&gt; [1] 0-9 0-9 10-19 50-59 30-39 70-79 100+ 40-49 20-29
#&gt; 11 Levels: 0-9 &lt; 10-19 &lt; 20-29 &lt; 30-39 &lt; 40-49 &lt; 50-59 &lt; 60-69 &lt; ... &lt; 100+</div><div class='input'><span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='kw'>split_at</span> <span class='kw'>=</span> <span class='st'>"tens"</span>)</div><div class='output co'>#&gt; [1] 0-9 0-9 10-19 50-59 30-39 70-79 100+ 40-49 20-29
#&gt; 11 Levels: 0-9 &lt; 10-19 &lt; 20-29 &lt; 30-39 &lt; 40-49 &lt; 50-59 &lt; 60-69 &lt; ... &lt; 100+</div><div class='input'>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='fl'>1</span>:<span class='fl'>10</span> * <span class='fl'>10</span>)
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='kw'>split_at</span> <span class='kw'>=</span> <span class='st'>"tens"</span>)
<span class='co'># split into groups of five years</span>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='fl'>1</span>:<span class='fl'>20</span> * <span class='fl'>5</span>)</div><div class='output co'>#&gt; [1] 0-4 5-9 15-19 50-54 30-34 75-79 100+ 40-44 20-24
#&gt; 21 Levels: 0-4 &lt; 5-9 &lt; 10-14 &lt; 15-19 &lt; 20-24 &lt; 25-29 &lt; 30-34 &lt; ... &lt; 100+</div><div class='input'><span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='kw'>split_at</span> <span class='kw'>=</span> <span class='st'>"fives"</span>)</div><div class='output co'>#&gt; [1] 0-4 5-9 15-19 50-54 30-34 75-79 100+ 40-44 20-24
#&gt; 21 Levels: 0-4 &lt; 5-9 &lt; 10-14 &lt; 15-19 &lt; 20-24 &lt; 25-29 &lt; 30-34 &lt; ... &lt; 100+</div><div class='input'>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='fl'>1</span>:<span class='fl'>20</span> * <span class='fl'>5</span>)
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='kw'>split_at</span> <span class='kw'>=</span> <span class='st'>"fives"</span>)
<span class='co'># split specifically for children</span>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='st'>"children"</span>)</div><div class='output co'>#&gt; [1] 2-3 6-12 13-17 18+ 18+ 18+ 18+ 18+ 18+
#&gt; Levels: 0 &lt; 1 &lt; 2-3 &lt; 4-5 &lt; 6-12 &lt; 13-17 &lt; 18+</div><div class='input'><span class='co'># same:</span>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='fl'>1</span>, <span class='fl'>2</span>, <span class='fl'>4</span>, <span class='fl'>6</span>, <span class='fl'>13</span>, <span class='fl'>17</span>))</div><div class='output co'>#&gt; [1] 2-3 6-12 13-16 17+ 17+ 17+ 17+ 17+ 17+
#&gt; Levels: 0 &lt; 1 &lt; 2-3 &lt; 4-5 &lt; 6-12 &lt; 13-16 &lt; 17+</div><div class='input'>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='st'>"children"</span>)
<span class='co'># same:</span>
<span class='fu'>age_groups</span>(<span class='no'>ages</span>, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='fl'>1</span>, <span class='fl'>2</span>, <span class='fl'>4</span>, <span class='fl'>6</span>, <span class='fl'>13</span>, <span class='fl'>17</span>))
<span class='co'># resistance of ciprofloxacine per age group</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>dplyr</span>)</div><div class='output co'>#&gt; <span class='message'></span>
#&gt; <span class='message'>Attaching package: ‘dplyr’</span></div><div class='output co'>#&gt; <span class='message'>The following object is masked from ‘package:testthat’:</span>
#&gt; <span class='message'></span>
#&gt; <span class='message'> matches</span></div><div class='output co'>#&gt; <span class='message'>The following objects are masked from ‘package:stats’:</span>
#&gt; <span class='message'></span>
#&gt; <span class='message'> filter, lag</span></div><div class='output co'>#&gt; <span class='message'>The following objects are masked from ‘package:base’:</span>
#&gt; <span class='message'></span>
#&gt; <span class='message'> intersect, setdiff, setequal, union</span></div><div class='input'><span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>dplyr</span>)
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/mutate.html'>mutate</a></span>(<span class='kw'>first_isolate</span> <span class='kw'>=</span> <span class='fu'><a href='first_isolate.html'>first_isolate</a></span>(<span class='no'>.</span>)) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/filter.html'>filter</a></span>(<span class='no'>first_isolate</span> <span class='kw'>==</span> <span class='fl'>TRUE</span>,
<span class='no'>mo</span> <span class='kw'>==</span> <span class='fu'><a href='as.mo.html'>as.mo</a></span>(<span class='st'>"E. coli"</span>)) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span>(<span class='kw'>age_group</span> <span class='kw'>=</span> <span class='fu'>age_groups</span>(<span class='no'>age</span>)) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(<span class='no'>age_group</span>,
<span class='no'>cipr</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='ggplot_rsi.html'>ggplot_rsi</a></span>(<span class='kw'>x</span> <span class='kw'>=</span> <span class='st'>"age_group"</span>)</div><div class='output co'>#&gt; <span class='message'><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>mo</span><span style='color: #0000BB;'>` as input for `col_mo`.</span><span></span></div><div class='output co'>#&gt; <span class='message'></span><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>date</span><span style='color: #0000BB;'>` as input for `col_date`.</span><span></span></div><div class='output co'>#&gt; <span class='message'></span><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>patient_id</span><span style='color: #0000BB;'>` as input for `col_patient_id`.</span><span></span></div><div class='output co'>#&gt; <span class='message'>=&gt; Found </span><span style='font-weight: bold;'>1,315 first isolates</span><span> (65.8% of total)</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Removed 3 rows containing missing values (geom_bar).</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Removed 3 rows containing missing values (geom_text).</span></div><div class='img'><img src='age_groups-1.png' alt='' width='700' height='433' /></div></span></pre>
<span class='fu'><a href='ggplot_rsi.html'>ggplot_rsi</a></span>(<span class='kw'>x</span> <span class='kw'>=</span> <span class='st'>"age_group"</span>)
<span class='co'># }</span></pre>
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@@ -218,7 +258,7 @@
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@@ -6,13 +6,20 @@
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<meta property="og:description" content="A data set containing all antibiotics with a J0 code and some other antimicrobial agents, with their DDDs. Except for trade names and abbreviations, all properties were downloaded from the WHO, see Source." />
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@@ -71,37 +88,64 @@
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@@ -184,6 +228,23 @@
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@@ -29,10 +36,20 @@
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<meta property="og:title" content="Transform to ATC code — as.atc" />
<meta property="og:description" content="Use this function to determine the ATC code of one or more antibiotics. The data set antibiotics will be searched for abbreviations, official names and trade names." />
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@@ -62,8 +79,8 @@
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<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">0.5.0.9007</span>
<a class="navbar-link" href="../index.html">AMR (for R)</a>
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@@ -71,37 +88,64 @@
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@@ -154,20 +198,23 @@
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='co'># These examples all return "J01FA01", the ATC code of Erythromycin:</span>
<span class='fu'>as.atc</span>(<span class='st'>"J01FA01"</span>)</div><div class='output co'>#&gt; Class 'atc'
#&gt; [1] J01FA01</div><div class='input'><span class='fu'>as.atc</span>(<span class='st'>"Erythromycin"</span>)</div><div class='output co'>#&gt; Class 'atc'
#&gt; [1] J01FA01</div><div class='input'><span class='fu'>as.atc</span>(<span class='st'>"eryt"</span>)</div><div class='output co'>#&gt; Class 'atc'
#&gt; [1] J01FA01</div><div class='input'><span class='fu'>as.atc</span>(<span class='st'>" eryt 123"</span>)</div><div class='output co'>#&gt; Class 'atc'
#&gt; [1] J01FA01</div><div class='input'><span class='fu'>as.atc</span>(<span class='st'>"ERYT"</span>)</div><div class='output co'>#&gt; Class 'atc'
#&gt; [1] J01FA01</div><div class='input'><span class='fu'>as.atc</span>(<span class='st'>"ERY"</span>)</div><div class='output co'>#&gt; Class 'atc'
#&gt; [1] J01FA01</div><div class='input'><span class='fu'>as.atc</span>(<span class='st'>"Erythrocin"</span>) <span class='co'># Trade name</span></div><div class='output co'>#&gt; Class 'atc'
#&gt; [1] J01FA01</div><div class='input'><span class='fu'>as.atc</span>(<span class='st'>"Eryzole"</span>) <span class='co'># Trade name</span></div><div class='output co'>#&gt; Class 'atc'
#&gt; [1] J01FA01</div><div class='input'><span class='fu'>as.atc</span>(<span class='st'>"Pediamycin"</span>) <span class='co'># Trade name</span></div><div class='output co'>#&gt; Class 'atc'
#&gt; [1] J01FA01</div><div class='input'>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='co'># These examples all return "J01FA01", the ATC code of Erythromycin:</span>
<span class='fu'>as.atc</span>(<span class='st'>"J01FA01"</span>)
<span class='fu'>as.atc</span>(<span class='st'>"Erythromycin"</span>)
<span class='fu'>as.atc</span>(<span class='st'>"eryt"</span>)
<span class='fu'>as.atc</span>(<span class='st'>" eryt 123"</span>)
<span class='fu'>as.atc</span>(<span class='st'>"ERYT"</span>)
<span class='fu'>as.atc</span>(<span class='st'>"ERY"</span>)
<span class='fu'>as.atc</span>(<span class='st'>"Erythrocin"</span>) <span class='co'># Trade name</span>
<span class='fu'>as.atc</span>(<span class='st'>"Eryzole"</span>) <span class='co'># Trade name</span>
<span class='fu'>as.atc</span>(<span class='st'>"Pediamycin"</span>) <span class='co'># Trade name</span>
<span class='co'># Use ab_* functions to get a specific property based on an ATC code</span>
<span class='no'>Cipro</span> <span class='kw'>&lt;-</span> <span class='fu'>as.atc</span>(<span class='st'>"cipro"</span>) <span class='co'># returns `J01MA02`</span>
<span class='fu'><a href='ab_property.html'>ab_official</a></span>(<span class='no'>Cipro</span>) <span class='co'># returns "Ciprofloxacin"</span></div><div class='output co'>#&gt; [1] "Ciprofloxacin"</div><div class='input'><span class='fu'><a href='ab_property.html'>ab_umcg</a></span>(<span class='no'>Cipro</span>) <span class='co'># returns "CIPR", the code used in the UMCG</span></div><div class='output co'>#&gt; [1] "CIPR"</div></pre>
<span class='fu'><a href='ab_property.html'>ab_official</a></span>(<span class='no'>Cipro</span>) <span class='co'># returns "Ciprofloxacin"</span>
<span class='fu'><a href='ab_property.html'>ab_umcg</a></span>(<span class='no'>Cipro</span>) <span class='co'># returns "CIPR", the code used in the UMCG</span>
<span class='co'># }</span></pre>
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@@ -188,7 +235,7 @@
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@@ -198,6 +245,23 @@
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@@ -6,13 +6,20 @@
<meta http-equiv="X-UA-Compatible" content="IE=edge">
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<title>Class 'mic' — as.mic • AMR</title>
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@@ -29,10 +36,20 @@
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<meta property="og:title" content="Class 'mic' — as.mic" />
<meta property="og:description" content="This transforms a vector to a new class mic, which is an ordered factor with valid MIC values as levels. Invalid MIC values will be translated as NA with a warning." />
<meta property="og:image" content="https://msberends.gitlab.io/logo.png" />
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@@ -62,8 +79,8 @@
<span class="icon-bar"></span>
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<a class="navbar-link" href="../index.html">AMR</a>
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<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">0.5.0.9008</span>
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@@ -71,37 +88,64 @@
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@@ -150,24 +194,17 @@
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='no'>mic_data</span> <span class='kw'>&lt;-</span> <span class='fu'>as.mic</span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"&gt;=32"</span>, <span class='st'>"1.0"</span>, <span class='st'>"1"</span>, <span class='st'>"1.00"</span>, <span class='fl'>8</span>, <span class='st'>"&lt;=0.128"</span>, <span class='st'>"8"</span>, <span class='st'>"16"</span>, <span class='st'>"16"</span>))</div><div class='output co'>#&gt; <span class='warning'>Warning: 1 results truncated (11%) that were invalid MICs: "1.00"</span></div><div class='input'><span class='fu'>is.mic</span>(<span class='no'>mic_data</span>)</div><div class='output co'>#&gt; [1] TRUE</div><div class='input'>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='no'>mic_data</span> <span class='kw'>&lt;-</span> <span class='fu'>as.mic</span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"&gt;=32"</span>, <span class='st'>"1.0"</span>, <span class='st'>"1"</span>, <span class='st'>"1.00"</span>, <span class='fl'>8</span>, <span class='st'>"&lt;=0.128"</span>, <span class='st'>"8"</span>, <span class='st'>"16"</span>, <span class='st'>"16"</span>))
<span class='fu'>is.mic</span>(<span class='no'>mic_data</span>)
<span class='co'># this can also coerce combined MIC/RSI values:</span>
<span class='fu'>as.mic</span>(<span class='st'>"&lt;=0.002; S"</span>) <span class='co'># will return &lt;=0.002</span></div><div class='output co'>#&gt; Class 'mic'
#&gt; [1] &lt;=0.002</div><div class='input'>
<span class='fu'><a href='https://www.rdocumentation.org/packages/graphics/topics/plot'>plot</a></span>(<span class='no'>mic_data</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Factor `mic` contains implicit NA, consider using `forcats::fct_explicit_na`</span></div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/graphics/topics/barplot'>barplot</a></span>(<span class='no'>mic_data</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: Factor `mic` contains implicit NA, consider using `forcats::fct_explicit_na`</span></div><div class='img'><img src='as.mic-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'><a href='freq.html'>freq</a></span>(<span class='no'>mic_data</span>)</div><div class='output co'>#&gt;
#&gt;
#&gt; **Frequency table**
#&gt;
#&gt;
#&gt; | |Item | Count| Percent| Cum. Count| Cum. Percent|
#&gt; |:--|:-------|-----:|-------:|----------:|------------:|
#&gt; |1 |1 | 2| 25.0%| 2| 25.0%|
#&gt; |2 |8 | 2| 25.0%| 4| 50.0%|
#&gt; |3 |16 | 2| 25.0%| 6| 75.0%|
#&gt; |4 |&lt;=0.128 | 1| 12.5%| 7| 87.5%|
#&gt; |5 |&gt;=32 | 1| 12.5%| 8| 100.0%|
#&gt;
#&gt; </div></pre>
<span class='fu'>as.mic</span>(<span class='st'>"&lt;=0.002; S"</span>) <span class='co'># will return &lt;=0.002</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/graphics/topics/plot'>plot</a></span>(<span class='no'>mic_data</span>)
<span class='fu'><a href='https://www.rdocumentation.org/packages/graphics/topics/barplot'>barplot</a></span>(<span class='no'>mic_data</span>)
<span class='fu'><a href='freq.html'>freq</a></span>(<span class='no'>mic_data</span>)
<span class='co'># }</span></pre>
</div>
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<h2>Contents</h2>
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<meta property="og:description" content="Use this function to determine a valid microorganism ID (mo). Determination is done using Artificial Intelligence (AI) and the complete taxonomic kingdoms Bacteria, Fungi and Protozoa (see Source), so the input can be almost anything: a full name (like &quot;Staphylococcus aureus&quot;), an abbreviated name (like &quot;S. aureus&quot;), an abbreviation known in the field (like &quot;MRSA&quot;), or just a genus. You could also select a genus and species column, zie Examples." />
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@@ -219,37 +263,41 @@ The <code><a href='mo_property.html'>mo_property</a></code> functions (like <cod
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='co'># These examples all return "B_STPHY_AUR", the ID of S. aureus:</span>
<span class='fu'>as.mo</span>(<span class='st'>"stau"</span>)</div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_AUR</div><div class='input'><span class='fu'>as.mo</span>(<span class='st'>"STAU"</span>)</div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_AUR</div><div class='input'><span class='fu'>as.mo</span>(<span class='st'>"staaur"</span>)</div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_AUR</div><div class='input'><span class='fu'>as.mo</span>(<span class='st'>"S. aureus"</span>)</div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_AUR</div><div class='input'><span class='fu'>as.mo</span>(<span class='st'>"S aureus"</span>)</div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_AUR</div><div class='input'><span class='fu'>as.mo</span>(<span class='st'>"Staphylococcus aureus"</span>)</div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_AUR</div><div class='input'><span class='fu'>as.mo</span>(<span class='st'>"Staphylococcus aureus (MRSA)"</span>)</div><div class='output co'>#&gt; <span class='warning'>Warning: <span style='color: #BB0000;'>UNCERTAIN - "Staphylococcus aureus (MRSA)" -&gt; </span><span style='color: #BB0000;font-style: italic;'>Staphylococcus aureus</span><span style='color: #BB0000;'> (B_STPHY_AUR)</span><span></span></div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_AUR</div><div class='input'><span class='fu'>as.mo</span>(<span class='st'>"MRSA"</span>) <span class='co'># Methicillin Resistant S. aureus</span></div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_AUR</div><div class='input'><span class='fu'>as.mo</span>(<span class='st'>"VISA"</span>) <span class='co'># Vancomycin Intermediate S. aureus</span></div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_AUR</div><div class='input'><span class='fu'>as.mo</span>(<span class='st'>"VRSA"</span>) <span class='co'># Vancomycin Resistant S. aureus</span></div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_AUR</div><div class='input'><span class='fu'>as.mo</span>(<span class='fl'>369</span>) <span class='co'># Search on TSN (Taxonomic Serial Number), a unique identifier</span></div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_AUR</div><div class='input'> <span class='co'># for the Integrated Taxonomic Information System (ITIS)</span>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='co'># These examples all return "B_STPHY_AUR", the ID of S. aureus:</span>
<span class='fu'>as.mo</span>(<span class='st'>"stau"</span>)
<span class='fu'>as.mo</span>(<span class='st'>"STAU"</span>)
<span class='fu'>as.mo</span>(<span class='st'>"staaur"</span>)
<span class='fu'>as.mo</span>(<span class='st'>"S. aureus"</span>)
<span class='fu'>as.mo</span>(<span class='st'>"S aureus"</span>)
<span class='fu'>as.mo</span>(<span class='st'>"Staphylococcus aureus"</span>)
<span class='fu'>as.mo</span>(<span class='st'>"Staphylococcus aureus (MRSA)"</span>)
<span class='fu'>as.mo</span>(<span class='st'>"MRSA"</span>) <span class='co'># Methicillin Resistant S. aureus</span>
<span class='fu'>as.mo</span>(<span class='st'>"VISA"</span>) <span class='co'># Vancomycin Intermediate S. aureus</span>
<span class='fu'>as.mo</span>(<span class='st'>"VRSA"</span>) <span class='co'># Vancomycin Resistant S. aureus</span>
<span class='fu'>as.mo</span>(<span class='fl'>369</span>) <span class='co'># Search on TSN (Taxonomic Serial Number), a unique identifier</span>
<span class='co'># for the Integrated Taxonomic Information System (ITIS)</span>
<span class='fu'>as.mo</span>(<span class='st'>"Streptococcus group A"</span>)
<span class='fu'>as.mo</span>(<span class='st'>"GAS"</span>) <span class='co'># Group A Streptococci</span>
<span class='fu'>as.mo</span>(<span class='st'>"GBS"</span>) <span class='co'># Group B Streptococci</span>
<span class='fu'>as.mo</span>(<span class='st'>"Streptococcus group A"</span>)</div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STRPTC_GRA</div><div class='input'><span class='fu'>as.mo</span>(<span class='st'>"GAS"</span>) <span class='co'># Group A Streptococci</span></div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STRPTC_GRA</div><div class='input'><span class='fu'>as.mo</span>(<span class='st'>"GBS"</span>) <span class='co'># Group B Streptococci</span></div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STRPTC_GRB</div><div class='input'>
<span class='co'># guess_mo is an alias of as.mo and works the same</span>
<span class='fu'>guess_mo</span>(<span class='st'>"S. epidermidis"</span>) <span class='co'># will remain species: B_STPHY_EPI</span></div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_EPI</div><div class='input'><span class='fu'>guess_mo</span>(<span class='st'>"S. epidermidis"</span>, <span class='kw'>Becker</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>) <span class='co'># will not remain species: B_STPHY_CNS</span></div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STPHY_CNS</div><div class='input'>
<span class='fu'>guess_mo</span>(<span class='st'>"S. pyogenes"</span>) <span class='co'># will remain species: B_STRPTC_PYO</span></div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STRPTC_PYO</div><div class='input'><span class='fu'>guess_mo</span>(<span class='st'>"S. pyogenes"</span>, <span class='kw'>Lancefield</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>) <span class='co'># will not remain species: B_STRPTC_GRA</span></div><div class='output co'>#&gt; Class 'mo'
#&gt; [1] B_STRPTC_GRA</div><div class='input'>
<span class='fu'>guess_mo</span>(<span class='st'>"S. epidermidis"</span>) <span class='co'># will remain species: B_STPHY_EPI</span>
<span class='fu'>guess_mo</span>(<span class='st'>"S. epidermidis"</span>, <span class='kw'>Becker</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>) <span class='co'># will not remain species: B_STPHY_CNS</span>
<span class='fu'>guess_mo</span>(<span class='st'>"S. pyogenes"</span>) <span class='co'># will remain species: B_STRPTC_PYO</span>
<span class='fu'>guess_mo</span>(<span class='st'>"S. pyogenes"</span>, <span class='kw'>Lancefield</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>) <span class='co'># will not remain species: B_STRPTC_GRA</span>
<span class='co'># Use mo_* functions to get a specific property based on `mo`</span>
<span class='no'>Ecoli</span> <span class='kw'>&lt;-</span> <span class='fu'>as.mo</span>(<span class='st'>"E. coli"</span>) <span class='co'># returns `B_ESCHR_COL`</span>
<span class='fu'><a href='mo_property.html'>mo_genus</a></span>(<span class='no'>Ecoli</span>) <span class='co'># returns "Escherichia"</span></div><div class='output co'>#&gt; [1] "Escherichia"</div><div class='input'><span class='fu'><a href='mo_property.html'>mo_gramstain</a></span>(<span class='no'>Ecoli</span>) <span class='co'># returns "Gram negative"</span></div><div class='output co'>#&gt; [1] "Gram-negatief"</div><div class='input'><span class='co'># but it uses as.mo internally too, so you could also just use:</span>
<span class='fu'><a href='mo_property.html'>mo_genus</a></span>(<span class='st'>"E. coli"</span>) <span class='co'># returns "Escherichia"</span></div><div class='output co'>#&gt; [1] "Escherichia"</div><div class='input'>
<span class='fu'><a href='mo_property.html'>mo_genus</a></span>(<span class='no'>Ecoli</span>) <span class='co'># returns "Escherichia"</span>
<span class='fu'><a href='mo_property.html'>mo_gramstain</a></span>(<span class='no'>Ecoli</span>) <span class='co'># returns "Gram negative"</span>
<span class='co'># but it uses as.mo internally too, so you could also just use:</span>
<span class='fu'><a href='mo_property.html'>mo_genus</a></span>(<span class='st'>"E. coli"</span>) <span class='co'># returns "Escherichia"</span>
</div></span><span class='co'># NOT RUN {</span>
<span class='co'># }</span><span class='co'># NOT RUN {</span>
<span class='no'>df</span>$<span class='no'>mo</span> <span class='kw'>&lt;-</span> <span class='fu'>as.mo</span>(<span class='no'>df</span>$<span class='no'>microorganism_name</span>)
<span class='co'># the select function of tidyverse is also supported:</span>
@@ -290,7 +338,7 @@ The <code><a href='mo_property.html'>mo_property</a></code> functions (like <cod
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@@ -300,6 +348,23 @@ The <code><a href='mo_property.html'>mo_property</a></code> functions (like <cod
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<h1>Class 'rsi'</h1>
<div class="hidden name"><code>as.rsi.Rd</code></div>
</div>
<div class="ref-description">
<p>This transforms a vector to a new class <code>rsi</code>, which is an ordered factor with levels <code>S &lt; I &lt; R</code>. Invalid antimicrobial interpretations will be translated as <code>NA</code> with a warning.</p>
</div>
<pre class="usage"><span class='fu'>as.rsi</span>(<span class='no'>x</span>)
<span class='fu'>is.rsi</span>(<span class='no'>x</span>)
<span class='fu'>is.rsi.eligible</span>(<span class='no'>x</span>)</pre>
<h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
<table class="ref-arguments">
<colgroup><col class="name" /><col class="desc" /></colgroup>
<tr>
<th>x</th>
<td><p>vector</p></td>
</tr>
</table>
<h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
<p>Ordered factor with new class <code>rsi</code></p>
<h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2>
<p>The function <code>is.rsi.eligible</code> returns <code>TRUE</code> when a columns contains only valid antimicrobial interpretations (S and/or I and/or R), and <code>FALSE</code> otherwise.</p>
<h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2>
<div class='dont-index'><p><code><a href='as.mic.html'>as.mic</a></code></p></div>
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='no'>rsi_data</span> <span class='kw'>&lt;-</span> <span class='fu'>as.rsi</span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/rep'>rep</a></span>(<span class='st'>"S"</span>, <span class='fl'>474</span>), <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/rep'>rep</a></span>(<span class='st'>"I"</span>, <span class='fl'>36</span>), <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/rep'>rep</a></span>(<span class='st'>"R"</span>, <span class='fl'>370</span>)))
<span class='no'>rsi_data</span> <span class='kw'>&lt;-</span> <span class='fu'>as.rsi</span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/rep'>rep</a></span>(<span class='st'>"S"</span>, <span class='fl'>474</span>), <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/rep'>rep</a></span>(<span class='st'>"I"</span>, <span class='fl'>36</span>), <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/rep'>rep</a></span>(<span class='st'>"R"</span>, <span class='fl'>370</span>), <span class='st'>"A"</span>, <span class='st'>"B"</span>, <span class='st'>"C"</span>))
<span class='fu'>is.rsi</span>(<span class='no'>rsi_data</span>)
<span class='co'># this can also coerce combined MIC/RSI values:</span>
<span class='fu'>as.rsi</span>(<span class='st'>"&lt;= 0.002; S"</span>) <span class='co'># will return S</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/graphics/topics/plot'>plot</a></span>(<span class='no'>rsi_data</span>) <span class='co'># for percentages</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/graphics/topics/barplot'>barplot</a></span>(<span class='no'>rsi_data</span>) <span class='co'># for frequencies</span>
<span class='fu'><a href='freq.html'>freq</a></span>(<span class='no'>rsi_data</span>) <span class='co'># frequency table with informative header</span>
<span class='co'># using dplyr's mutate</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>dplyr</span>)
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/summarise_all.html'>mutate_at</a></span>(<span class='fu'><a href='http://dplyr.tidyverse.org/reference/vars.html'>vars</a></span>(<span class='no'>peni</span>:<span class='no'>rifa</span>), <span class='no'>as.rsi</span>)
<span class='co'># fastest way to transform all columns with already valid AB results to class `rsi`:</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/summarise_all.html'>mutate_if</a></span>(<span class='no'>is.rsi.eligible</span>,
<span class='no'>as.rsi</span>)
<span class='co'># }</span></pre>
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@@ -186,21 +230,22 @@
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='co'># What's the ATC of amoxicillin?</span>
<span class='fu'><a href='as.atc.html'>guess_atc</a></span>(<span class='st'>"Amoxicillin"</span>)</div><div class='output co'>#&gt; Class 'atc'
#&gt; [1] J01CA04</div><div class='input'><span class='co'># [1] "J01CA04"</span>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='co'># What's the ATC of amoxicillin?</span>
<span class='fu'><a href='as.atc.html'>guess_atc</a></span>(<span class='st'>"Amoxicillin"</span>)
<span class='co'># [1] "J01CA04"</span>
<span class='co'># oral DDD (Defined Daily Dose) of amoxicillin</span>
<span class='fu'>atc_property</span>(<span class='st'>"J01CA04"</span>, <span class='st'>"DDD"</span>, <span class='st'>"O"</span>)</div><div class='output co'>#&gt; [1] 1.5</div><div class='input'><span class='co'># parenteral DDD (Defined Daily Dose) of amoxicillin</span>
<span class='fu'>atc_property</span>(<span class='st'>"J01CA04"</span>, <span class='st'>"DDD"</span>, <span class='st'>"P"</span>)</div><div class='output co'>#&gt; [1] 3</div><div class='input'>
<span class='fu'>atc_property</span>(<span class='st'>"J01CA04"</span>, <span class='kw'>property</span> <span class='kw'>=</span> <span class='st'>"groups"</span>) <span class='co'># search hierarchical groups of amoxicillin</span></div><div class='output co'>#&gt; [1] "ANTIINFECTIVES FOR SYSTEMIC USE"
#&gt; [2] "ANTIBACTERIALS FOR SYSTEMIC USE"
#&gt; [3] "BETA-LACTAM ANTIBACTERIALS, PENICILLINS"
#&gt; [4] "Penicillins with extended spectrum" </div><div class='input'># [1] "ANTIINFECTIVES FOR SYSTEMIC USE"
# [2] "ANTIBACTERIALS FOR SYSTEMIC USE"
# [3] "BETA-LACTAM ANTIBACTERIALS, PENICILLINS"
# [4] "Penicillins with extended spectrum"
</div></pre>
<span class='fu'>atc_property</span>(<span class='st'>"J01CA04"</span>, <span class='st'>"DDD"</span>, <span class='st'>"O"</span>)
<span class='co'># parenteral DDD (Defined Daily Dose) of amoxicillin</span>
<span class='fu'>atc_property</span>(<span class='st'>"J01CA04"</span>, <span class='st'>"DDD"</span>, <span class='st'>"P"</span>)
<span class='fu'>atc_property</span>(<span class='st'>"J01CA04"</span>, <span class='kw'>property</span> <span class='kw'>=</span> <span class='st'>"groups"</span>) <span class='co'># search hierarchical groups of amoxicillin</span>
<span class='co'># [1] "ANTIINFECTIVES FOR SYSTEMIC USE"</span>
<span class='co'># [2] "ANTIBACTERIALS FOR SYSTEMIC USE"</span>
<span class='co'># [3] "BETA-LACTAM ANTIBACTERIALS, PENICILLINS"</span>
<span class='co'># [4] "Penicillins with extended spectrum"</span>
<span class='co'># }</span></pre>
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<meta property="og:description" content="These functions can be used to count resistant/susceptible microbial isolates. All functions support quasiquotation with pipes, can be used in dplyrs summarise and support grouped variables, see Examples.
count_R and count_IR can be used to count resistant isolates, count_S and count_SI can be used to count susceptible isolates." />
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@@ -72,37 +89,64 @@ count_R and count_IR can be used to count resistant isolates, count_S and count_
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@@ -187,18 +231,28 @@ count_R and count_IR can be used to count resistant isolates, count_S and count_
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='co'># septic_patients is a data set available in the AMR package. It is true, genuine data.</span>
?<span class='no'>septic_patients</span></div><div class='output co'>#&gt; <span class='message'>Rendering development documentation for 'septic_patients'</span></div><div class='input'>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='co'># septic_patients is a data set available in the AMR package. It is true, genuine data.</span>
?<span class='no'>septic_patients</span>
<span class='co'># Count resistant isolates</span>
<span class='fu'>count_R</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)</div><div class='output co'>#&gt; [1] 683</div><div class='input'><span class='fu'>count_IR</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)</div><div class='output co'>#&gt; [1] 686</div><div class='input'>
<span class='fu'>count_R</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)
<span class='fu'>count_IR</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)
<span class='co'># Or susceptible isolates</span>
<span class='fu'>count_S</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)</div><div class='output co'>#&gt; [1] 486</div><div class='input'><span class='fu'>count_SI</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)</div><div class='output co'>#&gt; [1] 489</div><div class='input'>
<span class='fu'>count_S</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)
<span class='fu'>count_SI</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)
<span class='co'># Count all available isolates</span>
<span class='fu'>count_all</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)</div><div class='output co'>#&gt; [1] 1172</div><div class='input'><span class='fu'>n_rsi</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)</div><div class='output co'>#&gt; [1] 1172</div><div class='input'>
<span class='fu'>count_all</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)
<span class='fu'>n_rsi</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)
<span class='co'># Since n_rsi counts available isolates, you can</span>
<span class='co'># calculate back to count e.g. non-susceptible isolates.</span>
<span class='co'># This results in the same:</span>
<span class='fu'>count_IR</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)</div><div class='output co'>#&gt; [1] 686</div><div class='input'><span class='fu'><a href='portion.html'>portion_IR</a></span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>) * <span class='fu'>n_rsi</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)</div><div class='output co'>#&gt; [1] 686</div><div class='input'>
<span class='fu'>count_IR</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)
<span class='fu'><a href='portion.html'>portion_IR</a></span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>) * <span class='fu'>n_rsi</span>(<span class='no'>septic_patients</span>$<span class='no'>amox</span>)
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>dplyr</span>)
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span>(<span class='no'>hospital_id</span>) <span class='kw'>%&gt;%</span>
@@ -207,50 +261,34 @@ count_R and count_IR can be used to count resistant isolates, count_S and count_
<span class='kw'>S</span> <span class='kw'>=</span> <span class='fu'>count_S</span>(<span class='no'>cipr</span>),
<span class='kw'>n1</span> <span class='kw'>=</span> <span class='fu'>count_all</span>(<span class='no'>cipr</span>), <span class='co'># the actual total; sum of all three</span>
<span class='kw'>n2</span> <span class='kw'>=</span> <span class='fu'>n_rsi</span>(<span class='no'>cipr</span>), <span class='co'># same - analogous to n_distinct</span>
<span class='kw'>total</span> <span class='kw'>=</span> <span class='fu'><a href='http://dplyr.tidyverse.org/reference/n.html'>n</a></span>()) <span class='co'># NOT the amount of tested isolates!</span></div><div class='output co'>#&gt; <span style='color: #949494;'># A tibble: 4 x 7</span><span>
#&gt; hospital_id R I S n1 n2 total
#&gt; </span><span style='color: #949494;font-style: italic;'>&lt;fct&gt;</span><span> </span><span style='color: #949494;font-style: italic;'>&lt;int&gt;</span><span> </span><span style='color: #949494;font-style: italic;'>&lt;int&gt;</span><span> </span><span style='color: #949494;font-style: italic;'>&lt;int&gt;</span><span> </span><span style='color: #949494;font-style: italic;'>&lt;int&gt;</span><span> </span><span style='color: #949494;font-style: italic;'>&lt;int&gt;</span><span> </span><span style='color: #949494;font-style: italic;'>&lt;int&gt;</span><span>
#&gt; </span><span style='color: #BCBCBC;'>1</span><span> A 26 3 178 207 207 321
#&gt; </span><span style='color: #BCBCBC;'>2</span><span> B 85 35 379 499 499 663
#&gt; </span><span style='color: #BCBCBC;'>3</span><span> C 41 22 139 202 202 254
#&gt; </span><span style='color: #BCBCBC;'>4</span><span> D 76 9 416 501 501 762</div><div class='input'>
<span class='kw'>total</span> <span class='kw'>=</span> <span class='fu'><a href='http://dplyr.tidyverse.org/reference/n.html'>n</a></span>()) <span class='co'># NOT the amount of tested isolates!</span>
<span class='co'># Count co-resistance between amoxicillin/clav acid and gentamicin,</span>
<span class='co'># so we can see that combination therapy does a lot more than mono therapy.</span>
<span class='co'># Please mind that `portion_S` calculates percentages right away instead.</span>
<span class='fu'>count_S</span>(<span class='no'>septic_patients</span>$<span class='no'>amcl</span>) <span class='co'># S = 1057 (67.1%)</span></div><div class='output co'>#&gt; [1] 1291</div><div class='input'><span class='fu'>count_all</span>(<span class='no'>septic_patients</span>$<span class='no'>amcl</span>) <span class='co'># n = 1576</span></div><div class='output co'>#&gt; [1] 1828</div><div class='input'>
<span class='fu'>count_S</span>(<span class='no'>septic_patients</span>$<span class='no'>gent</span>) <span class='co'># S = 1372 (74.0%)</span></div><div class='output co'>#&gt; [1] 1372</div><div class='input'><span class='fu'>count_all</span>(<span class='no'>septic_patients</span>$<span class='no'>gent</span>) <span class='co'># n = 1855</span></div><div class='output co'>#&gt; [1] 1855</div><div class='input'>
<span class='fu'>count_S</span>(<span class='no'>septic_patients</span>$<span class='no'>amcl</span>) <span class='co'># S = 1057 (67.1%)</span>
<span class='fu'>count_all</span>(<span class='no'>septic_patients</span>$<span class='no'>amcl</span>) <span class='co'># n = 1576</span>
<span class='fu'>count_S</span>(<span class='no'>septic_patients</span>$<span class='no'>gent</span>) <span class='co'># S = 1372 (74.0%)</span>
<span class='fu'>count_all</span>(<span class='no'>septic_patients</span>$<span class='no'>gent</span>) <span class='co'># n = 1855</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/with'>with</a></span>(<span class='no'>septic_patients</span>,
<span class='fu'>count_S</span>(<span class='no'>amcl</span>, <span class='no'>gent</span>)) <span class='co'># S = 1396 (92.0%)</span></div><div class='output co'>#&gt; [1] 1609</div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/with'>with</a></span>(<span class='no'>septic_patients</span>, <span class='co'># n = 1517</span>
<span class='fu'>n_rsi</span>(<span class='no'>amcl</span>, <span class='no'>gent</span>))</div><div class='output co'>#&gt; [1] 1747</div><div class='input'>
<span class='fu'>count_S</span>(<span class='no'>amcl</span>, <span class='no'>gent</span>)) <span class='co'># S = 1396 (92.0%)</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/with'>with</a></span>(<span class='no'>septic_patients</span>, <span class='co'># n = 1517</span>
<span class='fu'>n_rsi</span>(<span class='no'>amcl</span>, <span class='no'>gent</span>))
<span class='co'># Get portions S/I/R immediately of all rsi columns</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(<span class='no'>amox</span>, <span class='no'>cipr</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>count_df</span>(<span class='kw'>translate</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>)</div><div class='output co'>#&gt; Interpretation Antibiotic Value
#&gt; 1 S amox 486
#&gt; 2 I amox 3
#&gt; 3 R amox 683
#&gt; 4 S cipr 1112
#&gt; 5 I cipr 69
#&gt; 6 R cipr 228</div><div class='input'>
<span class='fu'>count_df</span>(<span class='kw'>translate</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>)
<span class='co'># It also supports grouping variables</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(<span class='no'>hospital_id</span>, <span class='no'>amox</span>, <span class='no'>cipr</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span>(<span class='no'>hospital_id</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>count_df</span>(<span class='kw'>translate</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>)</div><div class='output co'>#&gt; </span><span style='color: #949494;'># A tibble: 24 x 4</span><span>
#&gt; Interpretation hospital_id Antibiotic Value
#&gt; </span><span style='color: #949494;font-style: italic;'>&lt;ord&gt;</span><span> </span><span style='color: #949494;font-style: italic;'>&lt;fct&gt;</span><span> </span><span style='color: #949494;font-style: italic;'>&lt;chr&gt;</span><span> </span><span style='color: #949494;font-style: italic;'>&lt;int&gt;</span><span>
#&gt; </span><span style='color: #BCBCBC;'> 1</span><span> S A amox 63
#&gt; </span><span style='color: #BCBCBC;'> 2</span><span> S B amox 141
#&gt; </span><span style='color: #BCBCBC;'> 3</span><span> S C amox 59
#&gt; </span><span style='color: #BCBCBC;'> 4</span><span> S D amox 223
#&gt; </span><span style='color: #BCBCBC;'> 5</span><span> I A amox 0
#&gt; </span><span style='color: #BCBCBC;'> 6</span><span> I B amox 1
#&gt; </span><span style='color: #BCBCBC;'> 7</span><span> I C amox 0
#&gt; </span><span style='color: #BCBCBC;'> 8</span><span> I D amox 2
#&gt; </span><span style='color: #BCBCBC;'> 9</span><span> R A amox 87
#&gt; </span><span style='color: #BCBCBC;'>10</span><span> R B amox 231
#&gt; </span><span style='color: #949494;'># ... with 14 more rows</span><span></div><div class='input'>
</div></span></pre>
<span class='fu'>count_df</span>(<span class='kw'>translate</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>)
<span class='co'># }</span></pre>
</div>
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<h2>Contents</h2>
@@ -273,7 +311,7 @@ count_R and count_IR can be used to count resistant isolates, count_S and count_
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<p>Developed by <a href='https://www.rug.nl/staff/m.s.berends/'>Matthijs S. Berends</a>, <a href='https://www.rug.nl/staff/c.f.luz/'>Christian F. Luz</a>, <a href='https://www.rug.nl/staff/c.glasner/'>Corinna Glasner</a>, <a href='https://www.rug.nl/staff/a.w.friedrich/'>Alex W. Friedrich</a>, <a href='https://www.rug.nl/staff/b.sinha/'>Bhanu N. M. Sinha</a>.</p>
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@@ -283,6 +321,23 @@ count_R and count_IR can be used to count resistant isolates, count_S and count_
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<meta property="og:description" content="Apply susceptibility rules as defined by the European Committee on Antimicrobial Susceptibility Testing (EUCAST, http://eucast.org), see Source. This includes (1) expert rules, (2) intrinsic resistance and (3) inferred resistance as defined in their breakpoint tables." />
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@@ -265,48 +309,9 @@
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='no'>a</span> <span class='kw'>&lt;-</span> <span class='fu'>eucast_rules</span>(<span class='no'>septic_patients</span>)</div><div class='output co'>#&gt; <span class='message'><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>mo</span><span style='color: #0000BB;'>` as input for `col_mo`.</span><span></span></div><div class='output co'>#&gt; <span class='warning'>Warning: These columns do not exist and will be ignored: azlo, aztr, cefa, cfra, clar, dapt, erta, fusi, levo, linc, mezl, mino, nali, neom, neti, novo, norf, oflo, pipe, poly, pris, qida, roxi, siso, tica.</span>
#&gt; <span class='warning'>THIS MAY STRONGLY INFLUENCE THE OUTCOME.</span></div><div class='output co'>#&gt; Rules by the European Committee on Antimicrobial Susceptibility Testing (EUCAST)
#&gt; </span><span style='font-weight: bold;'>
#&gt; EUCAST Clinical Breakpoints (v8.1, 2018)
#&gt; </span><span>Enterobacteriales (Order)</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Staphylococcus</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Enterococcus</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Streptococcus</span><span> groups A, B, C, G</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Streptococcus pneumoniae</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Viridans group streptococci</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Haemophilus influenzae</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Moraxella catarrhalis</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Anaerobic Gram positives</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Anaerobic Gram negatives</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Pasteurella multocida</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Campylobacter jejuni</span><span> and </span><span style='font-style: italic;'>C. coli</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Aerococcus sanguinicola</span><span> and </span><span style='font-style: italic;'>A. urinae</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Kingella kingae</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-weight: bold;'>
#&gt; EUCAST Expert Rules, Intrinsic Resistance and Exceptional Phenotypes (v3.1, 2016)
#&gt; </span><span>Table 1: Intrinsic resistance in </span><span style='font-style: italic;'>Enterobacteriaceae</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 2: Intrinsic resistance in non-fermentative Gram-negative bacteria</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 3: Intrinsic resistance in other Gram-negative bacteria</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 4: Intrinsic resistance in Gram-positive bacteria</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 8: Interpretive rules for B-lactam agents and Gram-positive cocci</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 9: Interpretive rules for B-lactam agents and Gram-negative rods</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 10: Interpretive rules for B-lactam agents and other Gram-negative bacteria</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 11: Interpretive rules for macrolides, lincosamides, and streptogramins</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 12: Interpretive rules for aminoglycosides</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 13: Interpretive rules for quinolones</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-weight: bold;'>
#&gt; Other rules
#&gt; </span><span>Non-EUCAST: ampicillin = R where amoxicillin/clav acid = R</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Non-EUCAST: piperacillin = R where piperacillin/tazobactam = R</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Non-EUCAST: trimethoprim = R where trimethoprim/sulfa = R</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Non-EUCAST: amoxicillin/clav acid = S where ampicillin = S</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Non-EUCAST: piperacillin/tazobactam = S where piperacillin = S</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Non-EUCAST: trimethoprim/sulfa = S where trimethoprim = S</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-weight: bold;'>
#&gt; =&gt; EUCAST rules affected 1,980 out of 2,000 rows -&gt; </span><span style='color: #00BB00;font-weight: bold;'>changed 0 test results.
#&gt;
#&gt; </span><span></div><div class='input'>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='no'>a</span> <span class='kw'>&lt;-</span> <span class='fu'>eucast_rules</span>(<span class='no'>septic_patients</span>)
<span class='no'>a</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/data.frame'>data.frame</a></span>(<span class='kw'>mo</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"Staphylococcus aureus"</span>,
<span class='st'>"Enterococcus faecalis"</span>,
<span class='st'>"Escherichia coli"</span>,
@@ -321,72 +326,24 @@
<span class='kw'>cfox</span> <span class='kw'>=</span> <span class='st'>"S"</span>, <span class='co'># Cefoxitin</span>
<span class='kw'>stringsAsFactors</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>)
<span class='no'>a</span></div><div class='output co'>#&gt; mo vanc amox coli cfta cfur peni cfox
#&gt; 1 Staphylococcus aureus - - - - - S S
#&gt; 2 Enterococcus faecalis - - - - - S S
#&gt; 3 Escherichia coli - - - - - S S
#&gt; 4 Klebsiella pneumoniae - - - - - S S
#&gt; 5 Pseudomonas aeruginosa - - - - - S S</div><div class='input'><span class='co'># mo vanc amox coli cfta cfur peni cfox</span>
<span class='no'>a</span>
<span class='co'># mo vanc amox coli cfta cfur peni cfox</span>
<span class='co'># 1 Staphylococcus aureus - - - - - S S</span>
<span class='co'># 2 Enterococcus faecalis - - - - - S S</span>
<span class='co'># 3 Escherichia coli - - - - - S S</span>
<span class='co'># 4 Klebsiella pneumoniae - - - - - S S</span>
<span class='co'># 5 Pseudomonas aeruginosa - - - - - S S</span>
<span class='no'>b</span> <span class='kw'>&lt;-</span> <span class='fu'>eucast_rules</span>(<span class='no'>a</span>, <span class='st'>"mo"</span>) <span class='co'># 18 results are forced as R or S</span></div><div class='output co'>#&gt; <span class='warning'>Warning: These columns do not exist and will be ignored: amcl, amik, ampi, azit, azlo, aztr, cefa, cfra, cfep, cfot, cftr, chlo, cipr, clar, clin, clox, czol, dapt, doxy, erta, eryt, fosf, fusi, gent, imip, kana, levo, linc, line, mero, mezl, mino, moxi, nali, neom, neti, nitr, novo, norf, oflo, oxac, pipe, pita, poly, pris, qida, rifa, roxi, siso, teic, tetr, tica, tige, tobr, trim, trsu.</span>
#&gt; <span class='warning'>THIS MAY STRONGLY INFLUENCE THE OUTCOME.</span></div><div class='output co'>#&gt; Rules by the European Committee on Antimicrobial Susceptibility Testing (EUCAST)
#&gt; </span><span style='font-weight: bold;'>
#&gt; EUCAST Clinical Breakpoints (v8.1, 2018)
#&gt; </span><span>Enterobacteriales (Order)</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Staphylococcus</span><span style='color: #0000BB;'> (2 changes)
#&gt; </span><span style='font-style: italic;'>Enterococcus</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Streptococcus</span><span> groups A, B, C, G</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Streptococcus pneumoniae</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Viridans group streptococci</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Haemophilus influenzae</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Moraxella catarrhalis</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Anaerobic Gram positives</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Anaerobic Gram negatives</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Pasteurella multocida</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Campylobacter jejuni</span><span> and </span><span style='font-style: italic;'>C. coli</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Aerococcus sanguinicola</span><span> and </span><span style='font-style: italic;'>A. urinae</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-style: italic;'>Kingella kingae</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-weight: bold;'>
#&gt; EUCAST Expert Rules, Intrinsic Resistance and Exceptional Phenotypes (v3.1, 2016)
#&gt; </span><span>Table 1: Intrinsic resistance in </span><span style='font-style: italic;'>Enterobacteriaceae</span><span style='color: #0000BB;'> (5 changes)
#&gt; </span><span>Table 2: Intrinsic resistance in non-fermentative Gram-negative bacteria</span><span style='color: #0000BB;'> (5 changes)
#&gt; </span><span>Table 3: Intrinsic resistance in other Gram-negative bacteria</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 4: Intrinsic resistance in Gram-positive bacteria</span><span style='color: #0000BB;'> (6 changes)
#&gt; </span><span>Table 8: Interpretive rules for B-lactam agents and Gram-positive cocci</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 9: Interpretive rules for B-lactam agents and Gram-negative rods</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 10: Interpretive rules for B-lactam agents and other Gram-negative bacteria</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 11: Interpretive rules for macrolides, lincosamides, and streptogramins</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 12: Interpretive rules for aminoglycosides</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Table 13: Interpretive rules for quinolones</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-weight: bold;'>
#&gt; Other rules
#&gt; </span><span>Non-EUCAST: ampicillin = R where amoxicillin/clav acid = R</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Non-EUCAST: piperacillin = R where piperacillin/tazobactam = R</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Non-EUCAST: trimethoprim = R where trimethoprim/sulfa = R</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Non-EUCAST: amoxicillin/clav acid = S where ampicillin = S</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Non-EUCAST: piperacillin/tazobactam = S where piperacillin = S</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span>Non-EUCAST: trimethoprim/sulfa = S where trimethoprim = S</span><span style='color: #00BB00;'> (no changes)
#&gt; </span><span style='font-weight: bold;'>
#&gt; =&gt; EUCAST rules affected 5 out of 5 rows -&gt; </span><span style='color: #0000BB;font-weight: bold;'>changed 18 test results.
#&gt;
#&gt; </span><span></div><div class='input'>
<span class='no'>b</span></div><div class='output co'>#&gt; mo vanc amox coli cfta cfur peni cfox
#&gt; 1 Staphylococcus aureus - S R R S S S
#&gt; 2 Enterococcus faecalis - - R R R S R
#&gt; 3 Escherichia coli R - - - - R S
#&gt; 4 Klebsiella pneumoniae R R - - - R S
#&gt; 5 Pseudomonas aeruginosa R R - - R R R</div><div class='input'># mo vanc amox coli cfta cfur peni cfox
# 1 Staphylococcus aureus - S R R S S S
# 2 Enterococcus faecalis - - R R R S R
# 3 Escherichia coli R - - - - R S
# 4 Klebsiella pneumoniae R R - - - R S
# 5 Pseudomonas aeruginosa R R - - R R R
</div></span></pre>
<span class='no'>b</span> <span class='kw'>&lt;-</span> <span class='fu'>eucast_rules</span>(<span class='no'>a</span>, <span class='st'>"mo"</span>) <span class='co'># 18 results are forced as R or S</span>
<span class='no'>b</span>
<span class='co'># mo vanc amox coli cfta cfur peni cfox</span>
<span class='co'># 1 Staphylococcus aureus - S R R S S S</span>
<span class='co'># 2 Enterococcus faecalis - - R R R S R</span>
<span class='co'># 3 Escherichia coli R - - - - R S</span>
<span class='co'># 4 Klebsiella pneumoniae R R - - - R S</span>
<span class='co'># 5 Pseudomonas aeruginosa R R - - R R R</span>
<span class='co'># }</span></pre>
</div>
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<h2>Contents</h2>
@@ -407,7 +364,7 @@
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<h1>Determine first (weighted) isolates</h1>
<div class="hidden name"><code>first_isolate.Rd</code></div>
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<p>Determine first (weighted) isolates of all microorganisms of every patient per episode and (if needed) per specimen type.</p>
</div>
<pre class="usage"><span class='fu'>first_isolate</span>(<span class='no'>tbl</span>, <span class='kw'>col_date</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>col_patient_id</span> <span class='kw'>=</span> <span class='kw'>NULL</span>,
<span class='kw'>col_mo</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>col_testcode</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>col_specimen</span> <span class='kw'>=</span> <span class='kw'>NULL</span>,
<span class='kw'>col_icu</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>col_keyantibiotics</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>episode_days</span> <span class='kw'>=</span> <span class='fl'>365</span>,
<span class='kw'>testcodes_exclude</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>icu_exclude</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>,
<span class='kw'>specimen_group</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>type</span> <span class='kw'>=</span> <span class='st'>"keyantibiotics"</span>, <span class='kw'>ignore_I</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>,
<span class='kw'>points_threshold</span> <span class='kw'>=</span> <span class='fl'>2</span>, <span class='kw'>info</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>, <span class='no'>...</span>)
<span class='fu'>filter_first_isolate</span>(<span class='no'>tbl</span>, <span class='kw'>col_date</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>col_patient_id</span> <span class='kw'>=</span> <span class='kw'>NULL</span>,
<span class='kw'>col_mo</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='no'>...</span>)
<span class='fu'>filter_first_weighted_isolate</span>(<span class='no'>tbl</span>, <span class='kw'>col_date</span> <span class='kw'>=</span> <span class='kw'>NULL</span>,
<span class='kw'>col_patient_id</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>col_mo</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>col_keyantibiotics</span> <span class='kw'>=</span> <span class='kw'>NULL</span>,
<span class='no'>...</span>)</pre>
<h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
<table class="ref-arguments">
<colgroup><col class="name" /><col class="desc" /></colgroup>
<tr>
<th>tbl</th>
<td><p>a <code>data.frame</code> containing isolates.</p></td>
</tr>
<tr>
<th>col_date</th>
<td><p>column name of the result date (or date that is was received on the lab), defaults to the first column of class <code>Date</code></p></td>
</tr>
<tr>
<th>col_patient_id</th>
<td><p>column name of the unique IDs of the patients, defaults to the first column that starts with 'patient' or 'patid' (case insensitive)</p></td>
</tr>
<tr>
<th>col_mo</th>
<td><p>column name of the unique IDs of the microorganisms (see <code><a href='as.mo.html'>mo</a></code>), defaults to the first column of class <code>mo</code>. Values will be coerced using <code><a href='as.mo.html'>as.mo</a></code>.</p></td>
</tr>
<tr>
<th>col_testcode</th>
<td><p>column name of the test codes. Use <code>col_testcode = NULL</code> to <strong>not</strong> exclude certain test codes (like test codes for screening). In that case <code>testcodes_exclude</code> will be ignored.</p></td>
</tr>
<tr>
<th>col_specimen</th>
<td><p>column name of the specimen type or group</p></td>
</tr>
<tr>
<th>col_icu</th>
<td><p>column name of the logicals (<code>TRUE</code>/<code>FALSE</code>) whether a ward or department is an Intensive Care Unit (ICU)</p></td>
</tr>
<tr>
<th>col_keyantibiotics</th>
<td><p>column name of the key antibiotics to determine first <em>weighted</em> isolates, see <code><a href='key_antibiotics.html'>key_antibiotics</a></code>. Defaults to the first column that starts with 'key' followed by 'ab' or 'antibiotics' (case insensitive). Use <code>col_keyantibiotics = FALSE</code> to prevent this.</p></td>
</tr>
<tr>
<th>episode_days</th>
<td><p>episode in days after which a genus/species combination will be determined as 'first isolate' again</p></td>
</tr>
<tr>
<th>testcodes_exclude</th>
<td><p>character vector with test codes that should be excluded (case-insensitive)</p></td>
</tr>
<tr>
<th>icu_exclude</th>
<td><p>logical whether ICU isolates should be excluded (rows with value <code>TRUE</code> in column <code>col_icu</code>)</p></td>
</tr>
<tr>
<th>specimen_group</th>
<td><p>value in column <code>col_specimen</code> to filter on</p></td>
</tr>
<tr>
<th>type</th>
<td><p>type to determine weighed isolates; can be <code>"keyantibiotics"</code> or <code>"points"</code>, see Details</p></td>
</tr>
<tr>
<th>ignore_I</th>
<td><p>logical to determine whether antibiotic interpretations with <code>"I"</code> will be ignored when <code>type = "keyantibiotics"</code>, see Details</p></td>
</tr>
<tr>
<th>points_threshold</th>
<td><p>points until the comparison of key antibiotics will lead to inclusion of an isolate when <code>type = "points"</code>, see Details</p></td>
</tr>
<tr>
<th>info</th>
<td><p>print progress</p></td>
</tr>
<tr>
<th>...</th>
<td><p>parameters passed on to the <code>first_isolate</code> function</p></td>
</tr>
</table>
<h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2>
<p>Methodology of this function is based on: <strong>M39 Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data, 4th Edition</strong>, 2014, <em>Clinical and Laboratory Standards Institute (CLSI)</em>. <a href='https://clsi.org/standards/products/microbiology/documents/m39/'>https://clsi.org/standards/products/microbiology/documents/m39/</a>.</p>
<h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
<p>Logical vector</p>
<h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2>
<p><strong>WHY THIS IS SO IMPORTANT</strong> <br />
To conduct an analysis of antimicrobial resistance, you should only include the first isolate of every patient per episode <a href='https://www.ncbi.nlm.nih.gov/pubmed/17304462'>[1]</a>. If you would not do this, you could easily get an overestimate or underestimate of the resistance of an antibiotic. Imagine that a patient was admitted with an MRSA and that it was found in 5 different blood cultures the following week. The resistance percentage of oxacillin of all <em>S. aureus</em> isolates would be overestimated, because you included this MRSA more than once. It would be <a href='https://en.wikipedia.org/wiki/Selection_bias'>selection bias</a>.</p>
<p>The function <code>filter_first_isolate</code> is essentially equal to:</p><pre>
tbl %&gt;%
mutate(only_firsts = first_isolate(tbl, ...)) %&gt;%
filter(only_firsts == TRUE) %&gt;%
select(-only_firsts)
</pre><p>The function <code>filter_first_weighted_isolate</code> is essentially equal to:</p><pre>
tbl %&gt;%
mutate(keyab = key_antibiotics(.)) %&gt;%
mutate(only_weighted_firsts = first_isolate(tbl,
col_keyantibiotics = "keyab", ...)) %&gt;%
filter(only_weighted_firsts == TRUE) %&gt;%
select(-only_weighted_firsts)
</pre>
<h2 class="hasAnchor" id="key-antibiotics"><a class="anchor" href="#key-antibiotics"></a>Key antibiotics</h2>
<p>There are two ways to determine whether isolates can be included as first <em>weighted</em> isolates which will give generally the same results: <br /></p>
<p><strong>1. Using</strong> <code>type = "keyantibiotics"</code> <strong>and parameter</strong> <code>ignore_I</code> <br />
Any difference from S to R (or vice versa) will (re)select an isolate as a first weighted isolate. With <code>ignore_I = FALSE</code>, also differences from I to S|R (or vice versa) will lead to this. This is a reliable method and 30-35 times faster than method 2. <br /></p>
<p><strong>2. Using</strong> <code>type = "points"</code> <strong>and parameter</strong> <code>points_threshold</code> <br />
A difference from I to S|R (or vice versa) means 0.5 points, a difference from S to R (or vice versa) means 1 point. When the sum of points exceeds <code>points_threshold</code>, an isolate will be (re)selected as a first weighted isolate.</p>
<h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2>
<div class='dont-index'><p><code><a href='key_antibiotics.html'>key_antibiotics</a></code></p></div>
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='co'># septic_patients is a dataset available in the AMR package. It is true, genuine data.</span>
?<span class='no'>septic_patients</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>dplyr</span>)
<span class='co'># Filter on first isolates:</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/mutate.html'>mutate</a></span>(<span class='kw'>first_isolate</span> <span class='kw'>=</span> <span class='fu'>first_isolate</span>(<span class='no'>.</span>,
<span class='kw'>col_date</span> <span class='kw'>=</span> <span class='st'>"date"</span>,
<span class='kw'>col_patient_id</span> <span class='kw'>=</span> <span class='st'>"patient_id"</span>,
<span class='kw'>col_mo</span> <span class='kw'>=</span> <span class='st'>"mo"</span>)) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/filter.html'>filter</a></span>(<span class='no'>first_isolate</span> <span class='kw'>==</span> <span class='fl'>TRUE</span>)
<span class='co'># Which can be shortened to:</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'>filter_first_isolate</span>()
<span class='co'># or for first weighted isolates:</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'>filter_first_weighted_isolate</span>()
<span class='co'># Now let's see if first isolates matter:</span>
<span class='no'>A</span> <span class='kw'>&lt;-</span> <span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span>(<span class='no'>hospital_id</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/summarise.html'>summarise</a></span>(<span class='kw'>count</span> <span class='kw'>=</span> <span class='fu'><a href='count.html'>n_rsi</a></span>(<span class='no'>gent</span>), <span class='co'># gentamicin availability</span>
<span class='kw'>resistance</span> <span class='kw'>=</span> <span class='fu'><a href='portion.html'>portion_IR</a></span>(<span class='no'>gent</span>)) <span class='co'># gentamicin resistance</span>
<span class='no'>B</span> <span class='kw'>&lt;-</span> <span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'>filter_first_weighted_isolate</span>() <span class='kw'>%&gt;%</span> <span class='co'># the 1st isolate filter</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span>(<span class='no'>hospital_id</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/summarise.html'>summarise</a></span>(<span class='kw'>count</span> <span class='kw'>=</span> <span class='fu'><a href='count.html'>n_rsi</a></span>(<span class='no'>gent</span>), <span class='co'># gentamicin availability</span>
<span class='kw'>resistance</span> <span class='kw'>=</span> <span class='fu'><a href='portion.html'>portion_IR</a></span>(<span class='no'>gent</span>)) <span class='co'># gentamicin resistance</span>
<span class='co'># Have a look at A and B.</span>
<span class='co'># B is more reliable because every isolate is only counted once.</span>
<span class='co'># Gentamicin resitance in hospital D appears to be 5.4% higher than</span>
<span class='co'># when you (erroneously) would have used all isolates!</span>
<span class='co'>## OTHER EXAMPLES:</span>
<span class='co'># }</span><span class='co'># NOT RUN {</span>
<span class='co'># set key antibiotics to a new variable</span>
<span class='no'>tbl</span>$<span class='no'>keyab</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='key_antibiotics.html'>key_antibiotics</a></span>(<span class='no'>tbl</span>)
<span class='no'>tbl</span>$<span class='no'>first_isolate</span> <span class='kw'>&lt;-</span>
<span class='fu'>first_isolate</span>(<span class='no'>tbl</span>)
<span class='no'>tbl</span>$<span class='no'>first_isolate_weighed</span> <span class='kw'>&lt;-</span>
<span class='fu'>first_isolate</span>(<span class='no'>tbl</span>,
<span class='kw'>col_keyantibiotics</span> <span class='kw'>=</span> <span class='st'>'keyab'</span>)
<span class='no'>tbl</span>$<span class='no'>first_blood_isolate</span> <span class='kw'>&lt;-</span>
<span class='fu'>first_isolate</span>(<span class='no'>tbl</span>,
<span class='kw'>specimen_group</span> <span class='kw'>=</span> <span class='st'>'Blood'</span>)
<span class='no'>tbl</span>$<span class='no'>first_blood_isolate_weighed</span> <span class='kw'>&lt;-</span>
<span class='fu'>first_isolate</span>(<span class='no'>tbl</span>,
<span class='kw'>specimen_group</span> <span class='kw'>=</span> <span class='st'>'Blood'</span>,
<span class='kw'>col_keyantibiotics</span> <span class='kw'>=</span> <span class='st'>'keyab'</span>)
<span class='no'>tbl</span>$<span class='no'>first_urine_isolate</span> <span class='kw'>&lt;-</span>
<span class='fu'>first_isolate</span>(<span class='no'>tbl</span>,
<span class='kw'>specimen_group</span> <span class='kw'>=</span> <span class='st'>'Urine'</span>)
<span class='no'>tbl</span>$<span class='no'>first_urine_isolate_weighed</span> <span class='kw'>&lt;-</span>
<span class='fu'>first_isolate</span>(<span class='no'>tbl</span>,
<span class='kw'>specimen_group</span> <span class='kw'>=</span> <span class='st'>'Urine'</span>,
<span class='kw'>col_keyantibiotics</span> <span class='kw'>=</span> <span class='st'>'keyab'</span>)
<span class='no'>tbl</span>$<span class='no'>first_resp_isolate</span> <span class='kw'>&lt;-</span>
<span class='fu'>first_isolate</span>(<span class='no'>tbl</span>,
<span class='kw'>specimen_group</span> <span class='kw'>=</span> <span class='st'>'Respiratory'</span>)
<span class='no'>tbl</span>$<span class='no'>first_resp_isolate_weighed</span> <span class='kw'>&lt;-</span>
<span class='fu'>first_isolate</span>(<span class='no'>tbl</span>,
<span class='kw'>specimen_group</span> <span class='kw'>=</span> <span class='st'>'Respiratory'</span>,
<span class='kw'>col_keyantibiotics</span> <span class='kw'>=</span> <span class='st'>'keyab'</span>)
<span class='co'># }</span></pre>
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<ul class="nav nav-pills nav-stacked">
<li><a href="#arguments">Arguments</a></li>
<li><a href="#source">Source</a></li>
<li><a href="#value">Value</a></li>
<li><a href="#details">Details</a></li>
<li><a href="#key-antibiotics">Key antibiotics</a></li>
<li><a href="#see-also">See also</a></li>
<li><a href="#examples">Examples</a></li>
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<h1>Frequency table</h1>
<div class="hidden name"><code>freq.Rd</code></div>
</div>
<div class="ref-description">
<p>Create a frequency table of a vector with items or a data frame. Supports quasiquotation and markdown for reports. <code>top_freq</code> can be used to get the top/bottom <em>n</em> items of a frequency table, with counts as names.</p>
</div>
<pre class="usage"><span class='fu'>frequency_tbl</span>(<span class='no'>x</span>, <span class='no'>...</span>, <span class='kw'>sort.count</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>,
<span class='kw'>nmax</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/options'>getOption</a></span>(<span class='st'>"max.print.freq"</span>), <span class='kw'>na.rm</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>, <span class='kw'>row.names</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>,
<span class='kw'>markdown</span> <span class='kw'>=</span> !<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/interactive'>interactive</a></span>(), <span class='kw'>digits</span> <span class='kw'>=</span> <span class='fl'>2</span>, <span class='kw'>quote</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>,
<span class='kw'>header</span> <span class='kw'>=</span> !<span class='no'>markdown</span>, <span class='kw'>title</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>na</span> <span class='kw'>=</span> <span class='st'>"&lt;NA&gt;"</span>, <span class='kw'>droplevels</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>,
<span class='kw'>sep</span> <span class='kw'>=</span> <span class='st'>" "</span>, <span class='kw'>decimal.mark</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/options'>getOption</a></span>(<span class='st'>"OutDec"</span>),
<span class='kw'>big.mark</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/ifelse'>ifelse</a></span>(<span class='no'>decimal.mark</span> <span class='kw'>!=</span> <span class='st'>","</span>, <span class='st'>","</span>, <span class='st'>"."</span>))
<span class='fu'>freq</span>(<span class='no'>x</span>, <span class='no'>...</span>, <span class='kw'>sort.count</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>, <span class='kw'>nmax</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/options'>getOption</a></span>(<span class='st'>"max.print.freq"</span>),
<span class='kw'>na.rm</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>, <span class='kw'>row.names</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>, <span class='kw'>markdown</span> <span class='kw'>=</span> !<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/interactive'>interactive</a></span>(),
<span class='kw'>digits</span> <span class='kw'>=</span> <span class='fl'>2</span>, <span class='kw'>quote</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>, <span class='kw'>header</span> <span class='kw'>=</span> !<span class='no'>markdown</span>, <span class='kw'>title</span> <span class='kw'>=</span> <span class='kw'>NULL</span>,
<span class='kw'>na</span> <span class='kw'>=</span> <span class='st'>"&lt;NA&gt;"</span>, <span class='kw'>droplevels</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>, <span class='kw'>sep</span> <span class='kw'>=</span> <span class='st'>" "</span>,
<span class='kw'>decimal.mark</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/options'>getOption</a></span>(<span class='st'>"OutDec"</span>), <span class='kw'>big.mark</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/ifelse'>ifelse</a></span>(<span class='no'>decimal.mark</span> <span class='kw'>!=</span>
<span class='st'>","</span>, <span class='st'>","</span>, <span class='st'>"."</span>))
<span class='fu'>top_freq</span>(<span class='no'>f</span>, <span class='no'>n</span>)
<span class='fu'>header</span>(<span class='no'>f</span>, <span class='kw'>property</span> <span class='kw'>=</span> <span class='kw'>NULL</span>)
<span class='co'># S3 method for frequency_tbl</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='no'>x</span>, <span class='kw'>nmax</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/options'>getOption</a></span>(<span class='st'>"max.print.freq"</span>,
<span class='kw'>default</span> <span class='kw'>=</span> <span class='fl'>15</span>), <span class='kw'>markdown</span> <span class='kw'>=</span> !<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/interactive'>interactive</a></span>(), <span class='kw'>header</span> <span class='kw'>=</span> !<span class='no'>markdown</span>,
<span class='kw'>decimal.mark</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/options'>getOption</a></span>(<span class='st'>"OutDec"</span>), <span class='kw'>big.mark</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/ifelse'>ifelse</a></span>(<span class='no'>decimal.mark</span> <span class='kw'>!=</span>
<span class='st'>","</span>, <span class='st'>","</span>, <span class='st'>"."</span>), <span class='no'>...</span>)</pre>
<h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
<table class="ref-arguments">
<colgroup><col class="name" /><col class="desc" /></colgroup>
<tr>
<th>x</th>
<td><p>vector of any class or a <code><a href='https://www.rdocumentation.org/packages/base/topics/data.frame'>data.frame</a></code>, <code>tibble</code> (may contain a grouping variable) or <code><a href='https://www.rdocumentation.org/packages/base/topics/table'>table</a></code></p></td>
</tr>
<tr>
<th>...</th>
<td><p>up to nine different columns of <code>x</code> when <code>x</code> is a <code>data.frame</code> or <code>tibble</code>, to calculate frequencies from - see Examples</p></td>
</tr>
<tr>
<th>sort.count</th>
<td><p>sort on count, i.e. frequencies. This will be <code>TRUE</code> at default for everything except when using grouping variables.</p></td>
</tr>
<tr>
<th>nmax</th>
<td><p>number of row to print. The default, <code>15</code>, uses <code><a href='https://www.rdocumentation.org/packages/base/topics/options'>getOption</a>("max.print.freq")</code>. Use <code>nmax = 0</code>, <code>nmax = Inf</code>, <code>nmax = NULL</code> or <code>nmax = NA</code> to print all rows.</p></td>
</tr>
<tr>
<th>na.rm</th>
<td><p>a logical value indicating whether <code>NA</code> values should be removed from the frequency table. The header (if set) will always print the amount of <code>NA</code>s.</p></td>
</tr>
<tr>
<th>row.names</th>
<td><p>a logical value indicating whether row indices should be printed as <code>1:nrow(x)</code></p></td>
</tr>
<tr>
<th>markdown</th>
<td><p>a logical value indicating whether the frequency table should be printed in markdown format. This will print all rows (except when <code>nmax</code> is defined) and is default behaviour in non-interactive R sessions (like when knitting RMarkdown files).</p></td>
</tr>
<tr>
<th>digits</th>
<td><p>how many significant digits are to be used for numeric values in the header (not for the items themselves, that depends on <code><a href='https://www.rdocumentation.org/packages/base/topics/options'>getOption</a>("digits")</code>)</p></td>
</tr>
<tr>
<th>quote</th>
<td><p>a logical value indicating whether or not strings should be printed with surrounding quotes</p></td>
</tr>
<tr>
<th>header</th>
<td><p>a logical value indicating whether an informative header should be printed</p></td>
</tr>
<tr>
<th>title</th>
<td><p>text to show above frequency table, at default to tries to coerce from the variables passed to <code>x</code></p></td>
</tr>
<tr>
<th>na</th>
<td><p>a character string to should be used to show empty (<code>NA</code>) values (only useful when <code>na.rm = FALSE</code>)</p></td>
</tr>
<tr>
<th>droplevels</th>
<td><p>a logical value indicating whether in factors empty levels should be dropped</p></td>
</tr>
<tr>
<th>sep</th>
<td><p>a character string to separate the terms when selecting multiple columns</p></td>
</tr>
<tr>
<th>decimal.mark</th>
<td><p><!-- % -->
used for prettying (longish) numerical and complex sequences.
Passed to <code><a href='https://www.rdocumentation.org/packages/base/topics/formatc'>prettyNum</a></code>: that help page explains the details.</p></td>
</tr>
<tr>
<th>big.mark</th>
<td><p><!-- % -->
used for prettying (longish) numerical and complex sequences.
Passed to <code><a href='https://www.rdocumentation.org/packages/base/topics/formatc'>prettyNum</a></code>: that help page explains the details.</p></td>
</tr>
<tr>
<th>f</th>
<td><p>a frequency table</p></td>
</tr>
<tr>
<th>n</th>
<td><p>number of top <em>n</em> items to return, use -n for the bottom <em>n</em> items. It will include more than <code>n</code> rows if there are ties.</p></td>
</tr>
<tr>
<th>property</th>
<td><p>property in header to return this value directly</p></td>
</tr>
</table>
<h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
<p>A <code>data.frame</code> (with an additional class <code>"frequency_tbl"</code>) with five columns: <code>item</code>, <code>count</code>, <code>percent</code>, <code>cum_count</code> and <code>cum_percent</code>.</p>
<h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2>
<p>Frequency tables (or frequency distributions) are summaries of the distribution of values in a sample. With the `freq` function, you can create univariate frequency tables. Multiple variables will be pasted into one variable, so it forces a univariate distribution. This package also has a vignette available to explain the use of this function further, run <code><a href='https://www.rdocumentation.org/packages/utils/topics/browseVignettes'>browseVignettes("AMR")</a></code> to read it.</p>
<p>For numeric values of any class, these additional values will all be calculated with <code>na.rm = TRUE</code> and shown into the header:</p><ul>
<li><p>Mean, using <code><a href='https://www.rdocumentation.org/packages/base/topics/mean'>mean</a></code></p></li>
<li><p>Standard Deviation, using <code><a href='https://www.rdocumentation.org/packages/stats/topics/sd'>sd</a></code></p></li>
<li><p>Coefficient of Variation (CV), the standard deviation divided by the mean</p></li>
<li><p>Mean Absolute Deviation (MAD), using <code><a href='https://www.rdocumentation.org/packages/stats/topics/mad'>mad</a></code></p></li>
<li><p>Tukey Five-Number Summaries (minimum, Q1, median, Q3, maximum), using <code><a href='https://www.rdocumentation.org/packages/stats/topics/fivenum'>fivenum</a></code></p></li>
<li><p>Interquartile Range (IQR) calculated as <code>Q3 - Q1</code> using the Tukey Five-Number Summaries, i.e. <strong>not</strong> using the <code><a href='https://www.rdocumentation.org/packages/stats/topics/quantile'>quantile</a></code> function</p></li>
<li><p>Coefficient of Quartile Variation (CQV, sometimes called coefficient of dispersion), calculated as <code>(Q3 - Q1) / (Q3 + Q1)</code> using the Tukey Five-Number Summaries</p></li>
<li><p>Outliers (total count and unique count), using <code><a href='https://www.rdocumentation.org/packages/grDevices/topics/boxplot.stats'>boxplot.stats</a></code></p></li>
</ul>
<p>For dates and times of any class, these additional values will be calculated with <code>na.rm = TRUE</code> and shown into the header:</p><ul>
<li><p>Oldest, using <code><a href='https://www.rdocumentation.org/packages/base/topics/Extremes'>min</a></code></p></li>
<li><p>Newest, using <code><a href='https://www.rdocumentation.org/packages/base/topics/Extremes'>max</a></code>, with difference between newest and oldest</p></li>
<li><p>Median, using <code><a href='https://www.rdocumentation.org/packages/stats/topics/median'>median</a></code>, with percentage since oldest</p></li>
</ul>
<p>In factors, all factor levels that are not existing in the input data will be dropped.</p>
<p>The function <code>top_freq</code> uses <code><a href='http://dplyr.tidyverse.org/reference/top_n.html'>top_n</a></code> internally and will include more than <code>n</code> rows if there are ties.</p>
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>dplyr</span>)
<span class='co'># this all gives the same result:</span>
<span class='fu'>freq</span>(<span class='no'>septic_patients</span>$<span class='no'>hospital_id</span>)
<span class='fu'>freq</span>(<span class='no'>septic_patients</span>[, <span class='st'>"hospital_id"</span>])
<span class='no'>septic_patients</span>$<span class='no'>hospital_id</span> <span class='kw'>%&gt;%</span> <span class='fu'>freq</span>()
<span class='no'>septic_patients</span>[, <span class='st'>"hospital_id"</span>] <span class='kw'>%&gt;%</span> <span class='fu'>freq</span>()
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span> <span class='fu'>freq</span>(<span class='st'>"hospital_id"</span>)
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span> <span class='fu'>freq</span>(<span class='no'>hospital_id</span>) <span class='co'>#&lt;- easiest to remember (tidyverse)</span>
<span class='co'># you could also use `select` or `pull` to get your variables</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/filter.html'>filter</a></span>(<span class='no'>hospital_id</span> <span class='kw'>==</span> <span class='st'>"A"</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(<span class='no'>mo</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>()
<span class='co'># multiple selected variables will be pasted together</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='no'>left_join_microorganisms</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/filter.html'>filter</a></span>(<span class='no'>hospital_id</span> <span class='kw'>==</span> <span class='st'>"A"</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='no'>genus</span>, <span class='no'>species</span>)
<span class='co'># group a variable and analyse another</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span>(<span class='no'>hospital_id</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='no'>gender</span>)
<span class='co'># get top 10 bugs of hospital A as a vector</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/filter.html'>filter</a></span>(<span class='no'>hospital_id</span> <span class='kw'>==</span> <span class='st'>"A"</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='no'>mo</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>top_freq</span>(<span class='fl'>10</span>)
<span class='co'># save frequency table to an object</span>
<span class='no'>years</span> <span class='kw'>&lt;-</span> <span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/mutate.html'>mutate</a></span>(<span class='kw'>year</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/format'>format</a></span>(<span class='no'>date</span>, <span class='st'>"%Y"</span>)) <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='no'>year</span>)
<span class='co'># show only the top 5</span>
<span class='no'>years</span> <span class='kw'>%&gt;%</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/print'>print</a></span>(<span class='kw'>nmax</span> <span class='kw'>=</span> <span class='fl'>5</span>)
<span class='co'># save to an object with formatted percentages</span>
<span class='no'>years</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/format'>format</a></span>(<span class='no'>years</span>)
<span class='co'># print a histogram of numeric values</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='no'>age</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/graphics/topics/hist'>hist</a></span>()
<span class='co'># or print all points to a regular plot</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='no'>age</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/graphics/topics/plot'>plot</a></span>()
<span class='co'># transform to a data.frame or tibble</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='no'>age</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/as.data.frame'>as.data.frame</a></span>()
<span class='co'># or transform (back) to a vector</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='no'>age</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/vector'>as.vector</a></span>()
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/identical'>identical</a></span>(<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='no'>age</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/vector'>as.vector</a></span>() <span class='kw'>%&gt;%</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/sort'>sort</a></span>(),
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/sort'>sort</a></span>(<span class='no'>septic_patients</span>$<span class='no'>age</span>)) <span class='co'># TRUE</span>
<span class='co'># it also supports `table` objects</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/table'>table</a></span>(<span class='no'>septic_patients</span>$<span class='no'>gender</span>,
<span class='no'>septic_patients</span>$<span class='no'>age</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='kw'>sep</span> <span class='kw'>=</span> <span class='st'>" **sep** "</span>)
<span class='co'># only get selected columns</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='no'>hospital_id</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(<span class='no'>item</span>, <span class='no'>percent</span>)
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'>freq</span>(<span class='no'>hospital_id</span>) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(-<span class='no'>count</span>, -<span class='no'>cum_count</span>)
<span class='co'># check differences between frequency tables</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/diff'>diff</a></span>(<span class='fu'>freq</span>(<span class='no'>septic_patients</span>$<span class='no'>trim</span>),
<span class='fu'>freq</span>(<span class='no'>septic_patients</span>$<span class='no'>trsu</span>))
<span class='co'># }</span></pre>
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</ul>
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<meta property="og:description" content="g.test performs chi-squared contingency table tests and goodness-of-fit tests, just like chisq.test but is more reliable [1]. A G-test can be used to see whether the number of observations in each category fits a theoretical expectation (called a G-test of goodness-of-fit), or to see whether the proportions of one variable are different for different values of the other variable (called a G-test of independence)." />
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@@ -226,7 +270,8 @@
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='co'># = EXAMPLE 1 =</span>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='co'># = EXAMPLE 1 =</span>
<span class='co'># Shivrain et al. (2006) crossed clearfield rice (which are resistant</span>
<span class='co'># to the herbicide imazethapyr) with red rice (which are susceptible to</span>
<span class='co'># imazethapyr). They then crossed the hybrid offspring and examined the</span>
@@ -252,17 +297,13 @@
<span class='co'># observed 1752 right-billed and 1895 left-billed crossbills.</span>
<span class='no'>x</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='fl'>1752</span>, <span class='fl'>1895</span>)
<span class='fu'>g.test</span>(<span class='no'>x</span>)</div><div class='output co'>#&gt;
#&gt; G-test of goodness-of-fit (likelihood ratio test)
#&gt;
#&gt; data: x
#&gt; X-squared = 5.6085, df = 1, p-value = 0.01787
#&gt; </div><div class='input'># p = 0.01787343
<span class='fu'>g.test</span>(<span class='no'>x</span>)
<span class='co'># p = 0.01787343</span>
# There is a significant difference from a 1:1 ratio.
# Meaning: there are significantly more left-billed birds.
<span class='co'># There is a significant difference from a 1:1 ratio.</span>
<span class='co'># Meaning: there are significantly more left-billed birds.</span>
</div></pre>
<span class='co'># }</span></pre>
</div>
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<title>AMR bar plots with <code>ggplot</code> — ggplot_rsi • AMR (for R)</title>
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@@ -219,12 +263,14 @@
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>dplyr</span>)
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>dplyr</span>)
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>ggplot2</span>)
<span class='co'># get antimicrobial results for drugs against a UTI:</span>
<span class='fu'><a href='https://ggplot2.tidyverse.org/reference/ggplot.html'>ggplot</a></span>(<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span> <span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(<span class='no'>amox</span>, <span class='no'>nitr</span>, <span class='no'>fosf</span>, <span class='no'>trim</span>, <span class='no'>cipr</span>)) +
<span class='fu'>geom_rsi</span>()</div><div class='img'><img src='ggplot_rsi-1.png' alt='' width='700' height='433' /></div><div class='input'>
<span class='fu'>geom_rsi</span>()
<span class='co'># prettify the plot using some additional functions:</span>
<span class='no'>df</span> <span class='kw'>&lt;-</span> <span class='no'>septic_patients</span>[, <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"amox"</span>, <span class='st'>"nitr"</span>, <span class='st'>"fosf"</span>, <span class='st'>"trim"</span>, <span class='st'>"cipr"</span>)]
<span class='fu'><a href='https://ggplot2.tidyverse.org/reference/ggplot.html'>ggplot</a></span>(<span class='no'>df</span>) +
@@ -232,15 +278,18 @@
<span class='fu'>scale_y_percent</span>() +
<span class='fu'>scale_rsi_colours</span>() +
<span class='fu'>labels_rsi_count</span>() +
<span class='fu'>theme_rsi</span>()</div><div class='img'><img src='ggplot_rsi-2.png' alt='' width='700' height='433' /></div><div class='input'>
<span class='fu'>theme_rsi</span>()
<span class='co'># or better yet, simplify this using the wrapper function - a single command:</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(<span class='no'>amox</span>, <span class='no'>nitr</span>, <span class='no'>fosf</span>, <span class='no'>trim</span>, <span class='no'>cipr</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>ggplot_rsi</span>()</div><div class='img'><img src='ggplot_rsi-3.png' alt='' width='700' height='433' /></div><div class='input'>
<span class='fu'>ggplot_rsi</span>()
<span class='co'># get only portions and no counts:</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(<span class='no'>amox</span>, <span class='no'>nitr</span>, <span class='no'>fosf</span>, <span class='no'>trim</span>, <span class='no'>cipr</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>ggplot_rsi</span>(<span class='kw'>fun</span> <span class='kw'>=</span> <span class='no'>portion_df</span>)</div><div class='img'><img src='ggplot_rsi-4.png' alt='' width='700' height='433' /></div><div class='input'>
<span class='fu'>ggplot_rsi</span>(<span class='kw'>fun</span> <span class='kw'>=</span> <span class='no'>portion_df</span>)
<span class='co'># add other ggplot2 parameters as you like:</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(<span class='no'>amox</span>, <span class='no'>nitr</span>, <span class='no'>fosf</span>, <span class='no'>trim</span>, <span class='no'>cipr</span>) <span class='kw'>%&gt;%</span>
@@ -248,7 +297,8 @@
<span class='kw'>colour</span> <span class='kw'>=</span> <span class='st'>"black"</span>,
<span class='kw'>size</span> <span class='kw'>=</span> <span class='fl'>1</span>,
<span class='kw'>linetype</span> <span class='kw'>=</span> <span class='fl'>2</span>,
<span class='kw'>alpha</span> <span class='kw'>=</span> <span class='fl'>0.25</span>)</div><div class='img'><img src='ggplot_rsi-5.png' alt='' width='700' height='433' /></div><div class='input'>
<span class='kw'>alpha</span> <span class='kw'>=</span> <span class='fl'>0.25</span>)
<span class='co'># resistance of ciprofloxacine per age group</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/mutate.html'>mutate</a></span>(<span class='kw'>first_isolate</span> <span class='kw'>=</span> <span class='fu'><a href='first_isolate.html'>first_isolate</a></span>(<span class='no'>.</span>)) <span class='kw'>%&gt;%</span>
@@ -258,12 +308,13 @@
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span>(<span class='kw'>age_group</span> <span class='kw'>=</span> <span class='fu'><a href='age_groups.html'>age_groups</a></span>(<span class='no'>age</span>)) <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(<span class='no'>age_group</span>,
<span class='no'>cipr</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>ggplot_rsi</span>(<span class='kw'>x</span> <span class='kw'>=</span> <span class='st'>"age_group"</span>)</div><div class='output co'>#&gt; <span class='message'><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>mo</span><span style='color: #0000BB;'>` as input for `col_mo`.</span><span></span></div><div class='output co'>#&gt; <span class='message'></span><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>date</span><span style='color: #0000BB;'>` as input for `col_date`.</span><span></span></div><div class='output co'>#&gt; <span class='message'></span><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>patient_id</span><span style='color: #0000BB;'>` as input for `col_patient_id`.</span><span></span></div><div class='output co'>#&gt; <span class='message'>=&gt; Found </span><span style='font-weight: bold;'>1,315 first isolates</span><span> (65.8% of total)</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Removed 3 rows containing missing values (geom_bar).</span></div><div class='output co'>#&gt; <span class='warning'>Warning: Removed 3 rows containing missing values (geom_text).</span></div><div class='img'><img src='ggplot_rsi-6.png' alt='' width='700' height='433' /></div></span><div class='input'>
<span class='fu'>ggplot_rsi</span>(<span class='kw'>x</span> <span class='kw'>=</span> <span class='st'>"age_group"</span>)
<span class='co'># }</span><span class='co'># NOT RUN {</span>
<span class='co'># for colourblind mode, use divergent colours from the viridis package:</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/select.html'>select</a></span>(<span class='no'>amox</span>, <span class='no'>nitr</span>, <span class='no'>fosf</span>, <span class='no'>trim</span>, <span class='no'>cipr</span>) <span class='kw'>%&gt;%</span>
<span class='fu'>ggplot_rsi</span>() + <span class='fu'><a href='https://ggplot2.tidyverse.org/reference/scale_viridis.html'>scale_fill_viridis_d</a></span>()</div><div class='output co'>#&gt; <span class='message'>Scale for 'fill' is already present. Adding another scale for 'fill', which</span>
#&gt; <span class='message'>will replace the existing scale.</span></div><div class='img'><img src='ggplot_rsi-7.png' alt='' width='700' height='433' /></div><div class='input'>
<span class='fu'>ggplot_rsi</span>() + <span class='fu'><a href='https://ggplot2.tidyverse.org/reference/scale_viridis.html'>scale_fill_viridis_d</a></span>()
<span class='co'># it also supports groups (don't forget to use the group var on `x` or `facet`):</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
@@ -273,7 +324,8 @@
<span class='kw'>facet</span> <span class='kw'>=</span> <span class='no'>Antibiotic</span>,
<span class='kw'>nrow</span> <span class='kw'>=</span> <span class='fl'>1</span>) +
<span class='fu'><a href='https://ggplot2.tidyverse.org/reference/labs.html'>labs</a></span>(<span class='kw'>title</span> <span class='kw'>=</span> <span class='st'>"AMR of Anti-UTI Drugs Per Hospital"</span>,
<span class='kw'>x</span> <span class='kw'>=</span> <span class='st'>"Hospital"</span>)</div><div class='output co'>#&gt; <span class='error'>Error in ggplot_rsi(., x = hospital_id, facet = Antibiotic, nrow = 1): object 'hospital_id' not found</span></div><div class='input'>
<span class='kw'>x</span> <span class='kw'>=</span> <span class='st'>"Hospital"</span>)
<span class='co'># genuine analysis: check 2 most prevalent microorganisms</span>
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='co'># create new bacterial ID's, with all CoNS under the same group (Becker et al.)</span>
@@ -300,7 +352,8 @@
<span class='kw'>nrow</span> <span class='kw'>=</span> <span class='fl'>1</span>) +
<span class='fu'><a href='https://ggplot2.tidyverse.org/reference/labs.html'>labs</a></span>(<span class='kw'>title</span> <span class='kw'>=</span> <span class='st'>"AMR of Top Three Microorganisms In Blood Culture Isolates"</span>,
<span class='kw'>subtitle</span> <span class='kw'>=</span> <span class='st'>"Only First Isolates, CoNS grouped according to Becker et al. (2014)"</span>,
<span class='kw'>x</span> <span class='kw'>=</span> <span class='st'>"Microorganisms"</span>)</div><div class='output co'>#&gt; <span class='message'>=&gt; Found <span style='font-weight: bold;'>780 first isolates</span><span> (59.8% of total)</span></div><div class='output co'>#&gt; <span class='error'>Error in ggplot_rsi(., x = Antibiotic, facet = mo, translate_ab = FALSE, nrow = 1): object 'Antibiotic' not found</span></div></span></pre>
<span class='kw'>x</span> <span class='kw'>=</span> <span class='st'>"Microorganisms"</span>)
<span class='co'># }</span></pre>
</div>
<div class="col-md-3 hidden-xs hidden-sm" id="sidebar">
<h2>Contents</h2>
@@ -317,7 +370,7 @@
<footer>
<div class="copyright">
<p>Developed by Matthijs S. Berends, Christian F. Luz.</p>
<p>Developed by <a href='https://www.rug.nl/staff/m.s.berends/'>Matthijs S. Berends</a>, <a href='https://www.rug.nl/staff/c.f.luz/'>Christian F. Luz</a>, <a href='https://www.rug.nl/staff/c.glasner/'>Corinna Glasner</a>, <a href='https://www.rug.nl/staff/a.w.friedrich/'>Alex W. Friedrich</a>, <a href='https://www.rug.nl/staff/b.sinha/'>Bhanu N. M. Sinha</a>.</p>
</div>
<div class="pkgdown">
@@ -327,6 +380,23 @@
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392
public/reference/index.html → docs/reference/index.html
View File

@@ -6,13 +6,20 @@
<meta http-equiv="X-UA-Compatible" content="IE=edge">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title>Function reference • AMR</title>
<title>Function reference • AMR (for R)</title>
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@@ -29,9 +36,20 @@
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@@ -59,8 +77,8 @@
<span class="icon-bar"></span>
</button>
<span class="navbar-brand">
<a class="navbar-link" href="../index.html">AMR</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">0.5.0.9007</span>
<a class="navbar-link" href="../index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">0.5.0.9008</span>
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@@ -68,37 +86,64 @@
<ul class="nav navbar-nav">
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<a href="../news/index.html">Changelog</a>
<a href="../reference/">
<span class="fa fa-book-open"></span>
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@@ -123,48 +168,12 @@
<tbody>
<tr>
<th colspan="2">
<h2 id="section-all-functions" class="hasAnchor"><a href="#section-all-functions" class="anchor"></a>All functions</h2>
<p class="section-desc"></p>
<h2 id="section-cleaning-your-data" class="hasAnchor"><a href="#section-cleaning-your-data" class="anchor"></a>Cleaning your data</h2>
<p class="section-desc"><p>Functions for cleaning and optimising your data, to be able to add variables later on (like taxonomic properties) or to fix and extend antibiotic interpretations by applying EUCAST rules.</p></p>
</th>
</tr>
<tr>
<td>
<p><code><a href="AMR.html">AMR</a></code> </p>
</td>
<td><p>The <code>AMR</code> Package</p></td>
</tr><tr>
<td>
<p><code><a href="ab_property.html">ab_property()</a></code> <code><a href="ab_property.html">ab_atc()</a></code> <code><a href="ab_property.html">ab_official()</a></code> <code><a href="ab_property.html">ab_name()</a></code> <code><a href="ab_property.html">ab_trivial_nl()</a></code> <code><a href="ab_property.html">ab_certe()</a></code> <code><a href="ab_property.html">ab_umcg()</a></code> <code><a href="ab_property.html">ab_tradenames()</a></code> </p>
</td>
<td><p>Property of an antibiotic</p></td>
</tr><tr>
<td>
<p><code><a href="abname.html">abname()</a></code> </p>
</td>
<td><p>Name of an antibiotic</p></td>
</tr><tr>
<td>
<p><code><a href="age.html">age()</a></code> </p>
</td>
<td><p>Age in years of individuals</p></td>
</tr><tr>
<td>
<p><code><a href="age_groups.html">age_groups()</a></code> </p>
</td>
<td><p>Split ages into age groups</p></td>
</tr><tr>
<td>
<p><code><a href="antibiotics.html">antibiotics</a></code> </p>
</td>
<td><p>Data set with 423 antibiotics</p></td>
</tr><tr>
<td>
<p><code><a href="as.atc.html">as.atc()</a></code> <code><a href="as.atc.html">guess_atc()</a></code> <code><a href="as.atc.html">is.atc()</a></code> </p>
</td>
@@ -189,24 +198,26 @@
<td><p>Class 'rsi'</p></td>
</tr><tr>
<td>
<p><code><a href="atc_property.html">atc_property()</a></code> <code><a href="atc_property.html">atc_groups()</a></code> <code><a href="atc_property.html">atc_ddd()</a></code> </p>
</td>
<td><p>Properties of an ATC code</p></td>
</tr><tr>
<td>
<p><code><a href="count.html">count_R()</a></code> <code><a href="count.html">count_IR()</a></code> <code><a href="count.html">count_I()</a></code> <code><a href="count.html">count_SI()</a></code> <code><a href="count.html">count_S()</a></code> <code><a href="count.html">count_all()</a></code> <code><a href="count.html">n_rsi()</a></code> <code><a href="count.html">count_df()</a></code> </p>
</td>
<td><p>Count isolates</p></td>
</tr><tr>
<td>
<p><code><a href="eucast_rules.html">eucast_rules()</a></code> <code><a href="eucast_rules.html">EUCAST_rules()</a></code> <code><a href="eucast_rules.html">interpretive_reading()</a></code> </p>
</td>
<td><p>EUCAST rules</p></td>
</tr><tr>
<td>
<p><code><a href="read.4D.html">read.4D()</a></code> </p>
</td>
<td><p>Read data from 4D database</p></td>
</tr>
</tbody><tbody>
<tr>
<th colspan="2">
<h2 id="section-adding-variables-to-your-data" class="hasAnchor"><a href="#section-adding-variables-to-your-data" class="anchor"></a>Adding variables to your data</h2>
<p class="section-desc"><p>Functions to add new data to existing data, like the determination of first isolates,</p></p>
</th>
</tr>
<tr>
<td>
<p><code><a href="first_isolate.html">first_isolate()</a></code> <code><a href="first_isolate.html">filter_first_isolate()</a></code> <code><a href="first_isolate.html">filter_first_weighted_isolate()</a></code> </p>
</td>
@@ -214,7 +225,87 @@
</tr><tr>
<td>
<p><code><a href="freq.html">frequency_tbl()</a></code> <code><a href="freq.html">freq()</a></code> <code><a href="freq.html">top_freq()</a></code> <code><a href="freq.html">print(<i>&lt;frequency_tbl&gt;</i>)</a></code> </p>
<p><code><a href="mdro.html">mdro()</a></code> <code><a href="mdro.html">brmo()</a></code> <code><a href="mdro.html">mrgn()</a></code> <code><a href="mdro.html">eucast_exceptional_phenotypes()</a></code> </p>
</td>
<td><p>Determine multidrug-resistant organisms (MDRO)</p></td>
</tr><tr>
<td>
<p><code><a href="key_antibiotics.html">key_antibiotics()</a></code> <code><a href="key_antibiotics.html">key_antibiotics_equal()</a></code> </p>
</td>
<td><p>Key antibiotics for first <em>weighted</em> isolates</p></td>
</tr><tr>
<td>
<p><code><a href="mo_property.html">mo_fullname()</a></code> <code><a href="mo_property.html">mo_shortname()</a></code> <code><a href="mo_property.html">mo_subspecies()</a></code> <code><a href="mo_property.html">mo_species()</a></code> <code><a href="mo_property.html">mo_genus()</a></code> <code><a href="mo_property.html">mo_family()</a></code> <code><a href="mo_property.html">mo_order()</a></code> <code><a href="mo_property.html">mo_class()</a></code> <code><a href="mo_property.html">mo_phylum()</a></code> <code><a href="mo_property.html">mo_subkingdom()</a></code> <code><a href="mo_property.html">mo_kingdom()</a></code> <code><a href="mo_property.html">mo_type()</a></code> <code><a href="mo_property.html">mo_gramstain()</a></code> <code><a href="mo_property.html">mo_TSN()</a></code> <code><a href="mo_property.html">mo_ref()</a></code> <code><a href="mo_property.html">mo_authors()</a></code> <code><a href="mo_property.html">mo_year()</a></code> <code><a href="mo_property.html">mo_taxonomy()</a></code> <code><a href="mo_property.html">mo_property()</a></code> </p>
</td>
<td><p>Property of a microorganism</p></td>
</tr><tr>
<td>
<p><code><a href="ab_property.html">ab_property()</a></code> <code><a href="ab_property.html">ab_atc()</a></code> <code><a href="ab_property.html">ab_official()</a></code> <code><a href="ab_property.html">ab_name()</a></code> <code><a href="ab_property.html">ab_trivial_nl()</a></code> <code><a href="ab_property.html">ab_certe()</a></code> <code><a href="ab_property.html">ab_umcg()</a></code> <code><a href="ab_property.html">ab_tradenames()</a></code> </p>
</td>
<td><p>Property of an antibiotic</p></td>
</tr><tr>
<td>
<p><code><a href="atc_property.html">atc_property()</a></code> <code><a href="atc_property.html">atc_groups()</a></code> <code><a href="atc_property.html">atc_ddd()</a></code> </p>
</td>
<td><p>Properties of an ATC code</p></td>
</tr><tr>
<td>
<p><code><a href="abname.html">abname()</a></code> </p>
</td>
<td><p>Name of an antibiotic</p></td>
</tr><tr>
<td>
<p><code><a href="age.html">age()</a></code> </p>
</td>
<td><p>Age in years of individuals</p></td>
</tr><tr>
<td>
<p><code><a href="age_groups.html">age_groups()</a></code> </p>
</td>
<td><p>Split ages into age groups</p></td>
</tr><tr>
<td>
<p><code><a href="p.symbol.html">p.symbol()</a></code> </p>
</td>
<td><p>Symbol of a p value</p></td>
</tr><tr>
<td>
<p><code><a href="join.html">inner_join_microorganisms()</a></code> <code><a href="join.html">left_join_microorganisms()</a></code> <code><a href="join.html">right_join_microorganisms()</a></code> <code><a href="join.html">full_join_microorganisms()</a></code> <code><a href="join.html">semi_join_microorganisms()</a></code> <code><a href="join.html">anti_join_microorganisms()</a></code> </p>
</td>
<td><p>Join a table with <code>microorganisms</code></p></td>
</tr>
</tbody><tbody>
<tr>
<th colspan="2">
<h2 id="section-analysing-the-data" class="hasAnchor"><a href="#section-analysing-the-data" class="anchor"></a>Analysing the data</h2>
<p class="section-desc"><p>Functions for conducting AMR analysis</p></p>
</th>
</tr>
<tr>
<td>
<p><code><a href="count.html">count_R()</a></code> <code><a href="count.html">count_IR()</a></code> <code><a href="count.html">count_I()</a></code> <code><a href="count.html">count_SI()</a></code> <code><a href="count.html">count_S()</a></code> <code><a href="count.html">count_all()</a></code> <code><a href="count.html">n_rsi()</a></code> <code><a href="count.html">count_df()</a></code> </p>
</td>
<td><p>Count isolates</p></td>
</tr><tr>
<td>
<p><code><a href="portion.html">portion_R()</a></code> <code><a href="portion.html">portion_IR()</a></code> <code><a href="portion.html">portion_I()</a></code> <code><a href="portion.html">portion_SI()</a></code> <code><a href="portion.html">portion_S()</a></code> <code><a href="portion.html">portion_df()</a></code> </p>
</td>
<td><p>Calculate resistance of isolates</p></td>
</tr><tr>
<td>
<p><code><a href="freq.html">frequency_tbl()</a></code> <code><a href="freq.html">freq()</a></code> <code><a href="freq.html">top_freq()</a></code> <code><a href="freq.html">header()</a></code> <code><a href="freq.html">print(<i>&lt;frequency_tbl&gt;</i>)</a></code> </p>
</td>
<td><p>Frequency table</p></td>
</tr><tr>
@@ -225,30 +316,12 @@
<td><p><em>G</em>-test for Count Data</p></td>
</tr><tr>
<td>
<p><code><a href="get_locale.html">get_locale()</a></code> </p>
</td>
<td><p>Get language for AMR</p></td>
</tr><tr>
<td>
<p><code><a href="ggplot_rsi.html">ggplot_rsi()</a></code> <code><a href="ggplot_rsi.html">geom_rsi()</a></code> <code><a href="ggplot_rsi.html">facet_rsi()</a></code> <code><a href="ggplot_rsi.html">scale_y_percent()</a></code> <code><a href="ggplot_rsi.html">scale_rsi_colours()</a></code> <code><a href="ggplot_rsi.html">theme_rsi()</a></code> <code><a href="ggplot_rsi.html">labels_rsi_count()</a></code> </p>
</td>
<td><p>AMR bar plots with <code>ggplot</code></p></td>
</tr><tr>
<td>
<p><code><a href="join.html">inner_join_microorganisms()</a></code> <code><a href="join.html">left_join_microorganisms()</a></code> <code><a href="join.html">right_join_microorganisms()</a></code> <code><a href="join.html">full_join_microorganisms()</a></code> <code><a href="join.html">semi_join_microorganisms()</a></code> <code><a href="join.html">anti_join_microorganisms()</a></code> </p>
</td>
<td><p>Join a table with <code>microorganisms</code></p></td>
</tr><tr>
<td>
<p><code><a href="key_antibiotics.html">key_antibiotics()</a></code> <code><a href="key_antibiotics.html">key_antibiotics_equal()</a></code> </p>
</td>
<td><p>Key antibiotics for first <em>weighted</em> isolates</p></td>
</tr><tr>
<td>
<p><code><a href="kurtosis.html">kurtosis()</a></code> </p>
</td>
@@ -256,15 +329,35 @@
</tr><tr>
<td>
<p><code><a href="like.html">like()</a></code> <code><a href="like.html">`%like%`</a></code> </p>
<p><code><a href="resistance_predict.html">resistance_predict()</a></code> <code><a href="resistance_predict.html">rsi_predict()</a></code> </p>
</td>
<td><p>Pattern Matching</p></td>
<td><p>Predict antimicrobial resistance</p></td>
</tr><tr>
<td>
<p><code><a href="mdro.html">mdro()</a></code> <code><a href="mdro.html">brmo()</a></code> <code><a href="mdro.html">mrgn()</a></code> <code><a href="mdro.html">eucast_exceptional_phenotypes()</a></code> </p>
<p><code><a href="rsi.html">rsi()</a></code> </p>
</td>
<td><p>Determine multidrug-resistant organisms (MDRO)</p></td>
<td><p>Calculate resistance of isolates</p></td>
</tr><tr>
<td>
<p><code><a href="skewness.html">skewness()</a></code> </p>
</td>
<td><p>Skewness of the sample</p></td>
</tr>
</tbody><tbody>
<tr>
<th colspan="2">
<h2 id="section-included-data-sets" class="hasAnchor"><a href="#section-included-data-sets" class="anchor"></a>Included data sets</h2>
<p class="section-desc"><p>References for microorganisms and antibiotics, and even a genuine data set with isolates from septic patients.</p></p>
</th>
</tr>
<tr>
<td>
<p><code><a href="antibiotics.html">antibiotics</a></code> </p>
</td>
<td><p>Data set with 423 antibiotics</p></td>
</tr><tr>
<td>
@@ -273,6 +366,12 @@
<td><p>Data set with taxonomic data from ITIS</p></td>
</tr><tr>
<td>
<p><code><a href="septic_patients.html">septic_patients</a></code> </p>
</td>
<td><p>Data set with 2000 blood culture isolates of septic patients</p></td>
</tr><tr>
<td>
<p><code><a href="microorganisms.certe.html">microorganisms.certe</a></code> </p>
</td>
@@ -291,70 +390,42 @@
<td><p>Translation table for UMCG</p></td>
</tr><tr>
<td>
<p><code><a href="supplementary_data.html">microorganismsDT</a></code> <code><a href="supplementary_data.html">microorganisms.prevDT</a></code> <code><a href="supplementary_data.html">microorganisms.unprevDT</a></code> <code><a href="supplementary_data.html">microorganisms.oldDT</a></code> </p>
</td>
<td><p>Supplementary Data</p></td>
</tr>
</tbody><tbody>
<tr>
<th colspan="2">
<h2 id="section-other" class="hasAnchor"><a href="#section-other" class="anchor"></a>Other</h2>
<p class="section-desc"></p>
</th>
</tr>
<tr>
<td>
<p><code><a href="get_locale.html">get_locale()</a></code> </p>
</td>
<td><p>Get language for AMR</p></td>
</tr><tr>
<td>
<p><code><a href="like.html">like()</a></code> <code><a href="like.html">`%like%`</a></code> </p>
</td>
<td><p>Pattern Matching</p></td>
</tr><tr>
<td>
<p><code><a href="mo_failures.html">mo_failures()</a></code> </p>
</td>
<td><p>Vector of failed coercion attempts</p></td>
</tr><tr>
<td>
<p><code><a href="mo_property.html">mo_fullname()</a></code> <code><a href="mo_property.html">mo_shortname()</a></code> <code><a href="mo_property.html">mo_subspecies()</a></code> <code><a href="mo_property.html">mo_species()</a></code> <code><a href="mo_property.html">mo_genus()</a></code> <code><a href="mo_property.html">mo_family()</a></code> <code><a href="mo_property.html">mo_order()</a></code> <code><a href="mo_property.html">mo_class()</a></code> <code><a href="mo_property.html">mo_phylum()</a></code> <code><a href="mo_property.html">mo_subkingdom()</a></code> <code><a href="mo_property.html">mo_kingdom()</a></code> <code><a href="mo_property.html">mo_type()</a></code> <code><a href="mo_property.html">mo_gramstain()</a></code> <code><a href="mo_property.html">mo_TSN()</a></code> <code><a href="mo_property.html">mo_ref()</a></code> <code><a href="mo_property.html">mo_authors()</a></code> <code><a href="mo_property.html">mo_year()</a></code> <code><a href="mo_property.html">mo_taxonomy()</a></code> <code><a href="mo_property.html">mo_property()</a></code> </p>
</td>
<td><p>Property of a microorganism</p></td>
</tr><tr>
<td>
<p><code><a href="mo_renamed.html">mo_renamed()</a></code> </p>
</td>
<td><p>Vector of taxonomic renamed items</p></td>
</tr><tr>
<td>
<p><code><a href="p.symbol.html">p.symbol()</a></code> </p>
</td>
<td><p>Symbol of a p value</p></td>
</tr><tr>
<td>
<p><code><a href="portion.html">portion_R()</a></code> <code><a href="portion.html">portion_IR()</a></code> <code><a href="portion.html">portion_I()</a></code> <code><a href="portion.html">portion_SI()</a></code> <code><a href="portion.html">portion_S()</a></code> <code><a href="portion.html">portion_df()</a></code> </p>
</td>
<td><p>Calculate resistance of isolates</p></td>
</tr><tr>
<td>
<p><code><a href="read.4D.html">read.4D()</a></code> </p>
</td>
<td><p>Read data from 4D database</p></td>
</tr><tr>
<td>
<p><code><a href="resistance_predict.html">resistance_predict()</a></code> <code><a href="resistance_predict.html">rsi_predict()</a></code> </p>
</td>
<td><p>Predict antimicrobial resistance</p></td>
</tr><tr>
<td>
<p><code><a href="rsi.html">rsi()</a></code> </p>
</td>
<td><p>Calculate resistance of isolates</p></td>
</tr><tr>
<td>
<p><code><a href="septic_patients.html">septic_patients</a></code> </p>
</td>
<td><p>Data set with 2000 blood culture isolates of septic patients</p></td>
</tr><tr>
<td>
<p><code><a href="skewness.html">skewness()</a></code> </p>
</td>
<td><p>Skewness of the sample</p></td>
</tr><tr>
<td>
<p><code><a href="supplementary_data.html">microorganismsDT</a></code> <code><a href="supplementary_data.html">microorganisms.prevDT</a></code> <code><a href="supplementary_data.html">microorganisms.unprevDT</a></code> <code><a href="supplementary_data.html">microorganisms.oldDT</a></code> </p>
</td>
<td><p>Supplementary Data</p></td>
</tr>
</tbody>
</table>
@@ -363,14 +434,18 @@
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<h2>Contents</h2>
<ul class="nav nav-pills nav-stacked">
<li><a href="#section-all-functions">All functions</a></li>
<li><a href="#section-cleaning-your-data">Cleaning your data</a></li>
<li><a href="#section-adding-variables-to-your-data">Adding variables to your data</a></li>
<li><a href="#section-analysing-the-data">Analysing the data</a></li>
<li><a href="#section-included-data-sets">Included data sets</a></li>
<li><a href="#section-other">Other</a></li>
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<p>Developed by Matthijs S. Berends, Christian F. Luz.</p>
<p>Developed by <a href='https://www.rug.nl/staff/m.s.berends/'>Matthijs S. Berends</a>, <a href='https://www.rug.nl/staff/c.f.luz/'>Christian F. Luz</a>, <a href='https://www.rug.nl/staff/c.glasner/'>Corinna Glasner</a>, <a href='https://www.rug.nl/staff/a.w.friedrich/'>Alex W. Friedrich</a>, <a href='https://www.rug.nl/staff/b.sinha/'>Bhanu N. M. Sinha</a>.</p>
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@@ -380,6 +455,23 @@
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<h1>Join a table with <code>microorganisms</code></h1>
<div class="hidden name"><code>join.Rd</code></div>
</div>
<div class="ref-description">
<p>Join the dataset <code><a href='microorganisms.html'>microorganisms</a></code> easily to an existing table or character vector.</p>
</div>
<pre class="usage"><span class='fu'>inner_join_microorganisms</span>(<span class='no'>x</span>, <span class='kw'>by</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>suffix</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"2"</span>, <span class='st'>""</span>), <span class='no'>...</span>)
<span class='fu'>left_join_microorganisms</span>(<span class='no'>x</span>, <span class='kw'>by</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>suffix</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"2"</span>, <span class='st'>""</span>), <span class='no'>...</span>)
<span class='fu'>right_join_microorganisms</span>(<span class='no'>x</span>, <span class='kw'>by</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>suffix</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"2"</span>, <span class='st'>""</span>), <span class='no'>...</span>)
<span class='fu'>full_join_microorganisms</span>(<span class='no'>x</span>, <span class='kw'>by</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='kw'>suffix</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"2"</span>, <span class='st'>""</span>), <span class='no'>...</span>)
<span class='fu'>semi_join_microorganisms</span>(<span class='no'>x</span>, <span class='kw'>by</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='no'>...</span>)
<span class='fu'>anti_join_microorganisms</span>(<span class='no'>x</span>, <span class='kw'>by</span> <span class='kw'>=</span> <span class='kw'>NULL</span>, <span class='no'>...</span>)</pre>
<h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
<table class="ref-arguments">
<colgroup><col class="name" /><col class="desc" /></colgroup>
<tr>
<th>x</th>
<td><p>existing table to join, or character vector</p></td>
</tr>
<tr>
<th>by</th>
<td><p>a variable to join by - if left empty will search for a column with class <code>mo</code> (created with <code><a href='as.mo.html'>as.mo</a></code>) or will be <code>"mo"</code> if that column name exists in <code>x</code>, could otherwise be a column name of <code>x</code> with values that exist in <code>microorganisms$mo</code> (like <code>by = "bacteria_id"</code>), or another column in <code><a href='microorganisms.html'>microorganisms</a></code> (but then it should be named, like <code>by = c("my_genus_species" = "fullname")</code>)</p></td>
</tr>
<tr>
<th>suffix</th>
<td><p>if there are non-joined duplicate variables in <code>x</code> and <code>y</code>, these suffixes will be added to the output to disambiguate them. Should be a character vector of length 2.</p></td>
</tr>
<tr>
<th>...</th>
<td><p>other parameters to pass on to <code>dplyr::<a href='http://dplyr.tidyverse.org/reference/join.html'>join</a></code>.</p></td>
</tr>
</table>
<h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2>
<p><strong>Note:</strong> As opposed to the <code><a href='http://dplyr.tidyverse.org/reference/join.html'>join</a></code> functions of <code>dplyr</code>, characters vectors are supported and at default existing columns will get a suffix <code>"2"</code> and the newly joined columns will not get a suffix. See <code><a href='http://dplyr.tidyverse.org/reference/join.html'>join</a></code> for more information.</p>
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='fu'>left_join_microorganisms</span>(<span class='fu'><a href='as.mo.html'>as.mo</a></span>(<span class='st'>"K. pneumoniae"</span>))
<span class='fu'>left_join_microorganisms</span>(<span class='st'>"B_KLBSL_PNE"</span>)
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>dplyr</span>)
<span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span> <span class='fu'>left_join_microorganisms</span>()
<span class='no'>df</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/data.frame'>data.frame</a></span>(<span class='kw'>date</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/seq'>seq</a></span>(<span class='kw'>from</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/as.Date'>as.Date</a></span>(<span class='st'>"2018-01-01"</span>),
<span class='kw'>to</span> <span class='kw'>=</span> <span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/as.Date'>as.Date</a></span>(<span class='st'>"2018-01-07"</span>),
<span class='kw'>by</span> <span class='kw'>=</span> <span class='fl'>1</span>),
<span class='kw'>bacteria</span> <span class='kw'>=</span> <span class='fu'><a href='as.mo.html'>as.mo</a></span>(<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/c'>c</a></span>(<span class='st'>"S. aureus"</span>, <span class='st'>"MRSA"</span>, <span class='st'>"MSSA"</span>, <span class='st'>"STAAUR"</span>,
<span class='st'>"E. coli"</span>, <span class='st'>"E. coli"</span>, <span class='st'>"E. coli"</span>)),
<span class='kw'>stringsAsFactors</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>)
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/colnames'>colnames</a></span>(<span class='no'>df</span>)
<span class='no'>df_joined</span> <span class='kw'>&lt;-</span> <span class='fu'>left_join_microorganisms</span>(<span class='no'>df</span>, <span class='st'>"bacteria"</span>)
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/colnames'>colnames</a></span>(<span class='no'>df_joined</span>)
<span class='co'># }</span></pre>
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@@ -211,8 +255,10 @@
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='co'># septic_patients is a dataset available in the AMR package</span>
?<span class='no'>septic_patients</span></div><div class='output co'>#&gt; <span class='message'>Rendering development documentation for 'septic_patients'</span></div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>dplyr</span>)
<pre class="examples"><span class='co'># NOT RUN {</span>
<span class='co'># septic_patients is a dataset available in the AMR package</span>
?<span class='no'>septic_patients</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/library'>library</a></span>(<span class='no'>dplyr</span>)
<span class='co'># set key antibiotics to a new variable</span>
<span class='no'>my_patients</span> <span class='kw'>&lt;-</span> <span class='no'>septic_patients</span> <span class='kw'>%&gt;%</span>
<span class='fu'><a href='http://dplyr.tidyverse.org/reference/mutate.html'>mutate</a></span>(<span class='kw'>keyab</span> <span class='kw'>=</span> <span class='fu'>key_antibiotics</span>(<span class='no'>.</span>)) <span class='kw'>%&gt;%</span>
@@ -221,18 +267,23 @@
<span class='kw'>first_regular</span> <span class='kw'>=</span> <span class='fu'><a href='first_isolate.html'>first_isolate</a></span>(<span class='no'>.</span>, <span class='kw'>col_keyantibiotics</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>),
<span class='co'># and first WEIGHTED isolates</span>
<span class='kw'>first_weighted</span> <span class='kw'>=</span> <span class='fu'><a href='first_isolate.html'>first_isolate</a></span>(<span class='no'>.</span>, <span class='kw'>col_keyantibiotics</span> <span class='kw'>=</span> <span class='st'>"keyab"</span>)
)</div><div class='output co'>#&gt; <span class='message'><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>mo</span><span style='color: #0000BB;'>` as input for `col_mo`.</span><span></span></div><div class='output co'>#&gt; <span class='message'></span><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>mo</span><span style='color: #0000BB;'>` as input for `col_mo`.</span><span></span></div><div class='output co'>#&gt; <span class='message'></span><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>date</span><span style='color: #0000BB;'>` as input for `col_date`.</span><span></span></div><div class='output co'>#&gt; <span class='message'></span><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>patient_id</span><span style='color: #0000BB;'>` as input for `col_patient_id`.</span><span></span></div><div class='output co'>#&gt; <span class='message'>=&gt; Found </span><span style='font-weight: bold;'>1,315 first isolates</span><span> (65.8% of total)</span></div><div class='output co'>#&gt; <span class='message'></span><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>mo</span><span style='color: #0000BB;'>` as input for `col_mo`.</span><span></span></div><div class='output co'>#&gt; <span class='message'></span><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>date</span><span style='color: #0000BB;'>` as input for `col_date`.</span><span></span></div><div class='output co'>#&gt; <span class='message'></span><span style='color: #0000BB;'>NOTE: Using column `</span><span style='color: #0000BB;font-weight: bold;'>patient_id</span><span style='color: #0000BB;'>` as input for `col_patient_id`.</span><span></span></div><div class='output co'>#&gt; [Criterion] Inclusion based on key antibiotics, ignoring I.</div><div class='output co'>#&gt; <span class='message'>=&gt; Found </span><span style='font-weight: bold;'>1,411 first weighted isolates</span><span> (70.6% of total)</span></div><div class='input'>
)
<span class='co'># Check the difference, in this data set it results in 7% more isolates:</span>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/sum'>sum</a></span>(<span class='no'>my_patients</span>$<span class='no'>first_regular</span>, <span class='kw'>na.rm</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; [1] 1315</div><div class='input'><span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/sum'>sum</a></span>(<span class='no'>my_patients</span>$<span class='no'>first_weighted</span>, <span class='kw'>na.rm</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt; [1] 1411</div><div class='input'>
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/sum'>sum</a></span>(<span class='no'>my_patients</span>$<span class='no'>first_regular</span>, <span class='kw'>na.rm</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)
<span class='fu'><a href='https://www.rdocumentation.org/packages/base/topics/sum'>sum</a></span>(<span class='no'>my_patients</span>$<span class='no'>first_weighted</span>, <span class='kw'>na.rm</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)
<span class='co'># output of the `key_antibiotics` function could be like this:</span>
<span class='no'>strainA</span> <span class='kw'>&lt;-</span> <span class='st'>"SSSRR.S.R..S"</span>
<span class='no'>strainB</span> <span class='kw'>&lt;-</span> <span class='st'>"SSSIRSSSRSSS"</span>
<span class='fu'>key_antibiotics_equal</span>(<span class='no'>strainA</span>, <span class='no'>strainB</span>)</div><div class='output co'>#&gt; [1] TRUE</div><div class='input'><span class='co'># TRUE, because I is ignored (as well as missing values)</span>
<span class='fu'>key_antibiotics_equal</span>(<span class='no'>strainA</span>, <span class='no'>strainB</span>)
<span class='co'># TRUE, because I is ignored (as well as missing values)</span>
<span class='fu'>key_antibiotics_equal</span>(<span class='no'>strainA</span>, <span class='no'>strainB</span>, <span class='kw'>ignore_I</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>)</div><div class='output co'>#&gt; [1] FALSE</div><div class='input'># FALSE, because I is not ignored and so the 4th value differs
</div></span></pre>
<span class='fu'>key_antibiotics_equal</span>(<span class='no'>strainA</span>, <span class='no'>strainB</span>, <span class='kw'>ignore_I</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>)
<span class='co'># FALSE, because I is not ignored and so the 4th value differs</span>
<span class='co'># }</span></pre>
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@@ -166,7 +210,7 @@
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<p>Developed by <a href='https://www.rug.nl/staff/m.s.berends/'>Matthijs S. Berends</a>, <a href='https://www.rug.nl/staff/c.f.luz/'>Christian F. Luz</a>, <a href='https://www.rug.nl/staff/c.glasner/'>Corinna Glasner</a>, <a href='https://www.rug.nl/staff/a.w.friedrich/'>Alex W. Friedrich</a>, <a href='https://www.rug.nl/staff/b.sinha/'>Bhanu N. M. Sinha</a>.</p>
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