In Europe, a lot of medical microbiological laboratories already apply these rules (Brown et al., 2015). Our package features their latest insights -on intrinsic resistance and unusual phenotypes (v3.3, 2021).
Moreover, the eucast_rules() function we use for this purpose can also apply additional rules, like forcing ampicillin = R in isolates when diff --git a/articles/MDR.html b/articles/MDR.html index 08b3ffa1..a61f70d6 100644 --- a/articles/MDR.html +++ b/articles/MDR.html @@ -38,7 +38,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 @@ -402,19 +402,19 @@ names or codes, this would have worked exactly the same way:
eucast_rules()
head(my_TB_data) #> rifampicin isoniazid gatifloxacin ethambutol pyrazinamide moxifloxacin -#> 1 R S S R R S -#> 2 R R I I S S -#> 3 S R S S I S -#> 4 R R S R R R -#> 5 I I I S R R -#> 6 S I R R S R +#> 1 R S R I I R +#> 2 I I I R S I +#> 3 R S I R I R +#> 4 S S I I S I +#> 5 I S R S I R +#> 6 R R I S S I #> kanamycin -#> 1 S -#> 2 S -#> 3 I -#> 4 R -#> 5 S -#> 6 R
We can now add the interpretation of MDR-TB to our data set. You can use:
@@ -455,40 +455,40 @@ Unique: 5 1 Mono-resistant -3225 -64.50% -3225 -64.50% +3262 +65.24% +3262 +65.24% 2 Negative -963 -19.26% -4188 -83.76% +923 +18.46% +4185 +83.70% 3 Multi-drug-resistant -478 -9.56% -4666 -93.32% +446 +8.92% +4631 +92.62% 4 Poly-resistant -228 -4.56% -4894 -97.88% +258 +5.16% +4889 +97.78% 5 Extensively drug-resistant -106 -2.12% +111 +2.22% 5000 100.00% diff --git a/articles/PCA.html b/articles/PCA.html index a30ee677..e37dbf8a 100644 --- a/articles/PCA.html +++ b/articles/PCA.html @@ -38,7 +38,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 @@ -307,7 +307,7 @@ function: #> [1] "Caryophanales" "Enterobacterales" "Lactobacillales" "Pseudomonadales" #> Importance of components: #> PC1 PC2 PC3 PC4 PC5 PC6 PC7 -#> Standard deviation 2.1539 1.6807 0.6138 0.33879 0.20808 0.03140 9.577e-17 +#> Standard deviation 2.1539 1.6807 0.6138 0.33879 0.20808 0.03140 1.232e-16 #> Proportion of Variance 0.5799 0.3531 0.0471 0.01435 0.00541 0.00012 0.000e+00 #> Cumulative Proportion 0.5799 0.9330 0.9801 0.99446 0.99988 1.00000 1.000e+00
#> Groups (n=4, named as 'order'): diff --git a/articles/WHONET.html b/articles/WHONET.html index 498d52e9..6041476f 100644 --- a/articles/WHONET.html +++ b/articles/WHONET.html @@ -38,7 +38,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/articles/datasets.html b/articles/datasets.html index 1ade146b..a8d251c1 100644 --- a/articles/datasets.html +++ b/articles/datasets.html @@ -38,7 +38,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 @@ -193,7 +193,7 @@ Data sets for download / own use - 27 May 2023 + 22 June 2023 Source: vignettes/datasets.Rmd datasets.Rmd @@ -913,68 +913,70 @@ inhibitors clinical_breakpoints: Interpretation from MIC values & disk diameters to SIR -A data set with 18 271 rows and 11 columns, containing the following +A data set with 42 599 rows and 12 columns, containing the following column names:guideline, method, site, mo, rank_index, ab, ref_tbl, disk_dose, -breakpoint_S, breakpoint_R, and uti. +breakpoint_S, breakpoint_R, ecoff, and +uti. This data set is in R available as clinical_breakpoints, after you load the AMR package. -It was last updated on 20 April 2023 13:20:41 UTC. Find more info +It was last updated on 22 June 2023 13:10:59 UTC. Find more info about the structure of this data set here. Direct download links: Download as original -R Data Structure (RDS) file (43 kB) +R Data Structure (RDS) file (82 kB) Download as tab-separated -text file (1.9 MB) +text file (4.4 MB) Download as Microsoft -Excel workbook (0.8 MB) +Excel workbook (1.8 MB) Download as Apache -Feather file (0.7 MB) +Feather file (1.6 MB) Download as Apache -Parquet file (88 kB) +Parquet file (0.2 MB) Download as SAS data (SAS) file (3.6 MB) Download as SAS -transport (XPT) file (3.4 MB) +transport (XPT) file (10.6 MB) Download as IBM -SPSS Statistics data file (2.3 MB) +SPSS Statistics data file (5.8 MB) Download as Stata -DTA file (3.3 MB) +DTA file (10.5 MB) Source This data set contains interpretation rules for MIC values and disk -diffusion diameters. Included guidelines are CLSI (2013-2022) and EUCAST -(2013-2022). +diffusion diameters. Included guidelines are CLSI (2011-2023) and EUCAST +(2011-2023). Example content - - + + - - + + + guideline @@ -989,11 +991,12 @@ diffusion diameters. Included guidelines are CLSI (2013-2022) and EUCAST disk_dose breakpoint_S breakpoint_R +ecoff uti -EUCAST 2022 +EUCAST 2023 MIC F_ASPRG_MGTS @@ -1005,10 +1008,11 @@ diffusion diameters. Included guidelines are CLSI (2013-2022) and EUCAST 1 1 + FALSE -EUCAST 2022 +EUCAST 2023 MIC F_ASPRG_NIGR @@ -1020,10 +1024,11 @@ diffusion diameters. Included guidelines are CLSI (2013-2022) and EUCAST 1 1 + FALSE -EUCAST 2022 +EUCAST 2023 MIC F_CANDD_ALBC @@ -1035,10 +1040,11 @@ diffusion diameters. Included guidelines are CLSI (2013-2022) and EUCAST 1 1 + FALSE -EUCAST 2022 +EUCAST 2023 MIC F_CANDD_DBLN @@ -1050,10 +1056,11 @@ diffusion diameters. Included guidelines are CLSI (2013-2022) and EUCAST 1 1 + FALSE -EUCAST 2022 +EUCAST 2023 MIC F_CANDD_GLBR @@ -1065,10 +1072,11 @@ diffusion diameters. Included guidelines are CLSI (2013-2022) and EUCAST 1 1 + FALSE -EUCAST 2022 +EUCAST 2023 MIC F_CANDD_KRUS @@ -1080,6 +1088,7 @@ diffusion diameters. Included guidelines are CLSI (2013-2022) and EUCAST 1 1 + FALSE @@ -1380,13 +1389,13 @@ v3.3 (2021). dosage: Dosage Guidelines from EUCAST -A data set with 336 rows and 9 columns, containing the following +A data set with 503 rows and 9 columns, containing the following column names:ab, name, type, dose, dose_times, administration, notes, original_txt, and eucast_version. This data set is in R available as dosage, after you load the AMR package. -It was last updated on 14 November 2022 14:20:39 UTC. Find more info +It was last updated on 22 June 2023 13:10:59 UTC. Find more info about the structure of this data set here. Direct download links: @@ -1394,28 +1403,28 @@ about the structure of this data set tab-separated -text file (29 kB) +text file (43 kB) Download as Microsoft -Excel workbook (19 kB) +Excel workbook (25 kB) Download as Apache -Feather file (16 kB) +Feather file (21 kB) Download as Apache -Parquet file (8 kB) +Parquet file (9 kB) Download as SAS data (SAS) file (92 kB) Download as SAS -transport (XPT) file (79 kB) +transport (XPT) file (0.1 MB) Download as IBM -SPSS Statistics data file (43 kB) +SPSS Statistics data file (64 kB) Download as Stata -DTA file (82 kB) +DTA file (0.1 MB) Source @@ -1423,8 +1432,9 @@ DTA file (82 kB) EUCAST breakpoints used in this package are based on the dosages in this data set. Currently included dosages in the data set are meant for: ‘EUCAST Clinical -Breakpoint Tables’ v11.0 (2021) and ‘EUCAST Clinical -Breakpoint Tables’ v12.0 (2022). +Breakpoint Tables’ v11.0 (2021), ‘EUCAST Clinical +Breakpoint Tables’ v12.0 (2022), and ‘EUCAST Clinical +Breakpoint Tables’ v13.0 (2023). Example content @@ -1462,7 +1472,7 @@ Breakpoint Tables’ v12.0 (2022). iv 25-30 mg/kg x 1 iv -12 +13 AMX @@ -1473,7 +1483,7 @@ Breakpoint Tables’ v12.0 (2022). iv 2 g x 6 iv -12 +13 AMX @@ -1484,7 +1494,7 @@ Breakpoint Tables’ v12.0 (2022). iv 1 g x 3-4 iv -12 +13 AMX @@ -1495,7 +1505,7 @@ Breakpoint Tables’ v12.0 (2022). oral 0.75-1 g x 3 oral -12 +13 AMX @@ -1506,7 +1516,7 @@ Breakpoint Tables’ v12.0 (2022). oral 0.5 g x 3 oral -12 +13 AMX @@ -1517,7 +1527,7 @@ Breakpoint Tables’ v12.0 (2022). oral 0.5 g x 3 oral -12 +13 diff --git a/articles/index.html b/articles/index.html index 15d41a8c..aed198b9 100644 --- a/articles/index.html +++ b/articles/index.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/articles/other_pkg.html b/articles/other_pkg.html index 18ef9b92..c47ca0dd 100644 --- a/articles/other_pkg.html +++ b/articles/other_pkg.html @@ -38,7 +38,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/articles/resistance_predict.html b/articles/resistance_predict.html index 10ed2fee..5f272370 100644 --- a/articles/resistance_predict.html +++ b/articles/resistance_predict.html @@ -38,7 +38,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/articles/welcome_to_AMR.html b/articles/welcome_to_AMR.html index 69062a3f..dbf384e2 100644 --- a/articles/welcome_to_AMR.html +++ b/articles/welcome_to_AMR.html @@ -38,7 +38,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/authors.html b/authors.html index fb6d7ca2..a39de688 100644 --- a/authors.html +++ b/authors.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/deps/bootstrap-5.2.2/bootstrap.min.css b/deps/bootstrap-5.2.2/bootstrap.min.css index 2bfad949..012754fb 100644 --- a/deps/bootstrap-5.2.2/bootstrap.min.css +++ b/deps/bootstrap-5.2.2/bootstrap.min.css @@ -3,4 +3,4 @@ * Copyright 2011-2022 The Bootstrap Authors * Copyright 2011-2022 Twitter, Inc. * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE) - */@import url("font.css");:root{--bs-blue: #2c3e50;--bs-indigo: #6610f2;--bs-purple: #6f42c1;--bs-pink: #e83e8c;--bs-red: #e74c3c;--bs-orange: #fd7e14;--bs-yellow: #f39c12;--bs-green: #18bc9c;--bs-teal: #20c997;--bs-cyan: #3498db;--bs-black: #000;--bs-white: #fff;--bs-gray: #95a5a6;--bs-gray-dark: #343a40;--bs-gray-100: #f8f9fa;--bs-gray-200: #ecf0f1;--bs-gray-300: #dee2e6;--bs-gray-400: #ced4da;--bs-gray-500: #b4bcc2;--bs-gray-600: #95a5a6;--bs-gray-700: #7b8a8b;--bs-gray-800: #343a40;--bs-gray-900: #212529;--bs-default: #95a5a6;--bs-primary: #2c3e50;--bs-secondary: #95a5a6;--bs-success: #128F76;--bs-info: #60A799;--bs-warning: #f39c12;--bs-danger: #e74c3c;--bs-light: rgba(18,143,118,0.65098);--bs-dark: #7b8a8b;--bs-default-rgb: 149,165,166;--bs-primary-rgb: 44,62,80;--bs-secondary-rgb: 149,165,166;--bs-success-rgb: 18,143,118;--bs-info-rgb: 96,167,153;--bs-warning-rgb: 243,156,18;--bs-danger-rgb: 231,76,60;--bs-light-rgb: 18,143,118;--bs-dark-rgb: 123,138,139;--bs-white-rgb: 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992px){.navbar-expand-lg{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand-lg .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand-lg .navbar-nav .dropdown-menu{position:absolute}.navbar-expand-lg .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-lg .navbar-nav-scroll{overflow:visible}.navbar-expand-lg .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand-lg .navbar-toggler{display:none}.navbar-expand-lg .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-lg .offcanvas .offcanvas-header{display:none}.navbar-expand-lg .offcanvas 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!important;transform:none !important;transition:none}.navbar-expand-xl .offcanvas .offcanvas-header{display:none}.navbar-expand-xl .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}@media (min-width: 1400px){.navbar-expand-xxl{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand-xxl .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand-xxl .navbar-nav .dropdown-menu{position:absolute}.navbar-expand-xxl .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-xxl .navbar-nav-scroll{overflow:visible}.navbar-expand-xxl .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand-xxl .navbar-toggler{display:none}.navbar-expand-xxl .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-xxl .offcanvas .offcanvas-header{display:none}.navbar-expand-xxl .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}.navbar-expand{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand .navbar-nav .dropdown-menu{position:absolute}.navbar-expand .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand .navbar-nav-scroll{overflow:visible}.navbar-expand .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand .navbar-toggler{display:none}.navbar-expand .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand .offcanvas .offcanvas-header{display:none}.navbar-expand .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}.navbar-light{background-color:#2c3e50}.navbar-dark{background-color:#128F76;--bs-navbar-color: #fff;--bs-navbar-hover-color: #2c3e50;--bs-navbar-disabled-color: rgba(255,255,255,0.25);--bs-navbar-active-color: #2c3e50;--bs-navbar-brand-color: #fff;--bs-navbar-brand-hover-color: #fff;--bs-navbar-toggler-border-color: rgba(255,255,255,0.1);--bs-navbar-toggler-icon-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 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var(--bs-card-cap-padding-x);margin-bottom:0;color:var(--bs-card-cap-color);background-color:var(--bs-card-cap-bg);border-bottom:var(--bs-card-border-width) solid var(--bs-card-border-color)}.card-header:first-child{border-radius:var(--bs-card-inner-border-radius) var(--bs-card-inner-border-radius) 0 0}.card-footer{padding:var(--bs-card-cap-padding-y) var(--bs-card-cap-padding-x);color:var(--bs-card-cap-color);background-color:var(--bs-card-cap-bg);border-top:var(--bs-card-border-width) solid var(--bs-card-border-color)}.card-footer:last-child{border-radius:0 0 var(--bs-card-inner-border-radius) var(--bs-card-inner-border-radius)}.card-header-tabs{margin-right:calc(-.5 * var(--bs-card-cap-padding-x));margin-bottom:calc(-1 * var(--bs-card-cap-padding-y));margin-left:calc(-.5 * var(--bs-card-cap-padding-x));border-bottom:0}.card-header-tabs .nav-link.active{background-color:var(--bs-card-bg);border-bottom-color:var(--bs-card-bg)}.card-header-pills{margin-right:calc(-.5 * var(--bs-card-cap-padding-x));margin-left:calc(-.5 * var(--bs-card-cap-padding-x))}.card-img-overlay{position:absolute;top:0;right:0;bottom:0;left:0;padding:var(--bs-card-img-overlay-padding);border-radius:var(--bs-card-inner-border-radius)}.card-img,.card-img-top,.card-img-bottom{width:100%}.card-img,.card-img-top{border-top-left-radius:var(--bs-card-inner-border-radius);border-top-right-radius:var(--bs-card-inner-border-radius)}.card-img,.card-img-bottom{border-bottom-right-radius:var(--bs-card-inner-border-radius);border-bottom-left-radius:var(--bs-card-inner-border-radius)}.card-group>.card{margin-bottom:var(--bs-card-group-margin)}@media (min-width: 576px){.card-group{display:flex;display:-webkit-flex;flex-flow:row wrap;-webkit-flex-flow:row wrap}.card-group>.card{flex:1 0 0%;-webkit-flex:1 0 0%;margin-bottom:0}.card-group>.card+.card{margin-left:0;border-left:0}.card-group>.card:not(:last-child){border-top-right-radius:0;border-bottom-right-radius:0}.card-group>.card:not(:last-child) .card-img-top,.card-group>.card:not(:last-child) .card-header{border-top-right-radius:0}.card-group>.card:not(:last-child) .card-img-bottom,.card-group>.card:not(:last-child) .card-footer{border-bottom-right-radius:0}.card-group>.card:not(:first-child){border-top-left-radius:0;border-bottom-left-radius:0}.card-group>.card:not(:first-child) .card-img-top,.card-group>.card:not(:first-child) .card-header{border-top-left-radius:0}.card-group>.card:not(:first-child) .card-img-bottom,.card-group>.card:not(:first-child) .card-footer{border-bottom-left-radius:0}}.accordion{--bs-accordion-color: #212529;--bs-accordion-bg: #fff;--bs-accordion-transition: color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out,box-shadow 0.15s ease-in-out,border-radius 0.15s ease;--bs-accordion-border-color: var(--bs-border-color);--bs-accordion-border-width: 1px;--bs-accordion-border-radius: .375rem;--bs-accordion-inner-border-radius: calc(.375rem - 1px);--bs-accordion-btn-padding-x: 1.25rem;--bs-accordion-btn-padding-y: 1rem;--bs-accordion-btn-color: #212529;--bs-accordion-btn-bg: var(--bs-accordion-bg);--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23212529'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-icon-width: 1.25rem;--bs-accordion-btn-icon-transform: rotate(-180deg);--bs-accordion-btn-icon-transition: transform 0.2s ease-in-out;--bs-accordion-btn-active-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23283848'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-focus-border-color: #969fa8;--bs-accordion-btn-focus-box-shadow: 0 0 0 .25rem rgba(44,62,80,0.25);--bs-accordion-body-padding-x: 1.25rem;--bs-accordion-body-padding-y: 1rem;--bs-accordion-active-color: #283848;--bs-accordion-active-bg: #eaecee}.accordion-button{position:relative;display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;width:100%;padding:var(--bs-accordion-btn-padding-y) var(--bs-accordion-btn-padding-x);font-size:1rem;color:var(--bs-accordion-btn-color);text-align:left;background-color:var(--bs-accordion-btn-bg);border:0;border-radius:0;overflow-anchor:none;transition:var(--bs-accordion-transition)}@media (prefers-reduced-motion: reduce){.accordion-button{transition:none}}.accordion-button:not(.collapsed){color:var(--bs-accordion-active-color);background-color:var(--bs-accordion-active-bg);box-shadow:inset 0 calc(-1 * var(--bs-accordion-border-width)) 0 var(--bs-accordion-border-color)}.accordion-button:not(.collapsed)::after{background-image:var(--bs-accordion-btn-active-icon);transform:var(--bs-accordion-btn-icon-transform)}.accordion-button::after{flex-shrink:0;-webkit-flex-shrink:0;width:var(--bs-accordion-btn-icon-width);height:var(--bs-accordion-btn-icon-width);margin-left:auto;content:"";background-image:var(--bs-accordion-btn-icon);background-repeat:no-repeat;background-size:var(--bs-accordion-btn-icon-width);transition:var(--bs-accordion-btn-icon-transition)}@media (prefers-reduced-motion: reduce){.accordion-button::after{transition:none}}.accordion-button:hover{z-index:2}.accordion-button:focus{z-index:3;border-color:var(--bs-accordion-btn-focus-border-color);outline:0;box-shadow:var(--bs-accordion-btn-focus-box-shadow)}.accordion-header{margin-bottom:0}.accordion-item{color:var(--bs-accordion-color);background-color:var(--bs-accordion-bg);border:var(--bs-accordion-border-width) solid var(--bs-accordion-border-color)}.accordion-item:first-of-type{border-top-left-radius:var(--bs-accordion-border-radius);border-top-right-radius:var(--bs-accordion-border-radius)}.accordion-item:first-of-type .accordion-button{border-top-left-radius:var(--bs-accordion-inner-border-radius);border-top-right-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:not(:first-of-type){border-top:0}.accordion-item:last-of-type{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-item:last-of-type .accordion-button.collapsed{border-bottom-right-radius:var(--bs-accordion-inner-border-radius);border-bottom-left-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:last-of-type .accordion-collapse{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-body{padding:var(--bs-accordion-body-padding-y) var(--bs-accordion-body-padding-x)}.accordion-flush .accordion-collapse{border-width:0}.accordion-flush .accordion-item{border-right:0;border-left:0;border-radius:0}.accordion-flush .accordion-item:first-child{border-top:0}.accordion-flush .accordion-item:last-child{border-bottom:0}.accordion-flush .accordion-item .accordion-button,.accordion-flush .accordion-item .accordion-button.collapsed{border-radius:0}.breadcrumb{--bs-breadcrumb-padding-x: .75rem;--bs-breadcrumb-padding-y: .375rem;--bs-breadcrumb-margin-bottom: 1rem;--bs-breadcrumb-bg: ;--bs-breadcrumb-border-radius: .25rem;--bs-breadcrumb-divider-color: #95a5a6;--bs-breadcrumb-item-padding-x: .5rem;--bs-breadcrumb-item-active-color: #95a5a6;display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding:var(--bs-breadcrumb-padding-y) var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);list-style:none;background-color:var(--bs-breadcrumb-bg);border-radius:var(--bs-breadcrumb-border-radius)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, "/") /* rtl: var(--bs-breadcrumb-divider, "/") */}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.pagination{--bs-pagination-padding-x: .75rem;--bs-pagination-padding-y: .375rem;--bs-pagination-font-size:1rem;--bs-pagination-color: #fff;--bs-pagination-bg: #128F76;--bs-pagination-border-width: 0;--bs-pagination-border-color: rgba(0,0,0,0);--bs-pagination-border-radius: .375rem;--bs-pagination-hover-color: #fff;--bs-pagination-hover-bg: #094b3e;--bs-pagination-hover-border-color: rgba(0,0,0,0);--bs-pagination-focus-color: var(--bs-link-hover-color);--bs-pagination-focus-bg: #ecf0f1;--bs-pagination-focus-box-shadow: 0 0 0 .25rem rgba(44,62,80,0.25);--bs-pagination-active-color: #fff;--bs-pagination-active-bg: #094b3e;--bs-pagination-active-border-color: rgba(0,0,0,0);--bs-pagination-disabled-color: #ecf0f1;--bs-pagination-disabled-bg: #1bd3ae;--bs-pagination-disabled-border-color: rgba(0,0,0,0);display:flex;display:-webkit-flex;padding-left:0;list-style:none}.page-link{position:relative;display:block;padding:var(--bs-pagination-padding-y) var(--bs-pagination-padding-x);font-size:var(--bs-pagination-font-size);color:var(--bs-pagination-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-pagination-bg);border:var(--bs-pagination-border-width) solid var(--bs-pagination-border-color);transition:color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out,box-shadow 0.15s ease-in-out}@media (prefers-reduced-motion: reduce){.page-link{transition:none}}.page-link:hover{z-index:2;color:var(--bs-pagination-hover-color);background-color:var(--bs-pagination-hover-bg);border-color:var(--bs-pagination-hover-border-color)}.page-link:focus{z-index:3;color:var(--bs-pagination-focus-color);background-color:var(--bs-pagination-focus-bg);outline:0;box-shadow:var(--bs-pagination-focus-box-shadow)}.page-link.active,.active>.page-link{z-index:3;color:var(--bs-pagination-active-color);background-color:var(--bs-pagination-active-bg);border-color:var(--bs-pagination-active-border-color)}.page-link.disabled,.disabled>.page-link{color:var(--bs-pagination-disabled-color);pointer-events:none;background-color:var(--bs-pagination-disabled-bg);border-color:var(--bs-pagination-disabled-border-color)}.page-item:not(:first-child) .page-link{margin-left:0}.page-item:first-child .page-link{border-top-left-radius:var(--bs-pagination-border-radius);border-bottom-left-radius:var(--bs-pagination-border-radius)}.page-item:last-child .page-link{border-top-right-radius:var(--bs-pagination-border-radius);border-bottom-right-radius:var(--bs-pagination-border-radius)}.pagination-lg{--bs-pagination-padding-x: 1.5rem;--bs-pagination-padding-y: .75rem;--bs-pagination-font-size:1.25rem;--bs-pagination-border-radius: .5rem}.pagination-sm{--bs-pagination-padding-x: .5rem;--bs-pagination-padding-y: .25rem;--bs-pagination-font-size:.875rem;--bs-pagination-border-radius: .25rem}.badge{--bs-badge-padding-x: .65em;--bs-badge-padding-y: .35em;--bs-badge-font-size:.75em;--bs-badge-font-weight: 700;--bs-badge-color: #fff;--bs-badge-border-radius: .375rem;display:inline-block;padding:var(--bs-badge-padding-y) var(--bs-badge-padding-x);font-size:var(--bs-badge-font-size);font-weight:var(--bs-badge-font-weight);line-height:1;color:var(--bs-badge-color);text-align:center;white-space:nowrap;vertical-align:baseline;border-radius:var(--bs-badge-border-radius)}.badge:empty{display:none}.btn .badge{position:relative;top:-1px}.alert{--bs-alert-bg: transparent;--bs-alert-padding-x: 1rem;--bs-alert-padding-y: 1rem;--bs-alert-margin-bottom: 1rem;--bs-alert-color: inherit;--bs-alert-border-color: transparent;--bs-alert-border: 1px solid var(--bs-alert-border-color);--bs-alert-border-radius: .375rem;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border);border-radius:var(--bs-alert-border-radius)}.alert-heading{color:inherit}.alert-link{font-weight:700}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-default{--bs-alert-color: #596364;--bs-alert-bg: #eaeded;--bs-alert-border-color: #dfe4e4}.alert-default .alert-link{color:#474f50}.alert-primary{--bs-alert-color: #1a2530;--bs-alert-bg: #d5d8dc;--bs-alert-border-color: #c0c5cb}.alert-primary .alert-link{color:#151e26}.alert-secondary{--bs-alert-color: #596364;--bs-alert-bg: #eaeded;--bs-alert-border-color: #dfe4e4}.alert-secondary .alert-link{color:#474f50}.alert-success{--bs-alert-color: #0b5647;--bs-alert-bg: #d0e9e4;--bs-alert-border-color: #b8ddd6}.alert-success .alert-link{color:#094539}.alert-info{--bs-alert-color: #3a645c;--bs-alert-bg: #dfedeb;--bs-alert-border-color: #cfe5e0}.alert-info .alert-link{color:#2e504a}.alert-warning{--bs-alert-color: #925e0b;--bs-alert-bg: #fdebd0;--bs-alert-border-color: #fbe1b8}.alert-warning .alert-link{color:#754b09}.alert-danger{--bs-alert-color: #8b2e24;--bs-alert-bg: #fadbd8;--bs-alert-border-color: #f8c9c5}.alert-danger .alert-link{color:#6f251d}.alert-light{--bs-alert-color: rgba(8,60,50,0.790588);--bs-alert-bg: rgba(229,243,240,0.930196);--bs-alert-border-color: rgba(214,236,232,0.895294)}.alert-light .alert-link{color:rgba(6,43,36,0.832471)}.alert-dark{--bs-alert-color: #4a5353;--bs-alert-bg: #e5e8e8;--bs-alert-border-color: #d7dcdc}.alert-dark .alert-link{color:#3b4242}@keyframes progress-bar-stripes{0%{background-position-x:1rem}}.progress{--bs-progress-height: 1rem;--bs-progress-font-size:.75rem;--bs-progress-bg: #ecf0f1;--bs-progress-border-radius: .375rem;--bs-progress-box-shadow: inset 0 1px 2px rgba(0,0,0,0.075);--bs-progress-bar-color: #fff;--bs-progress-bar-bg: #2c3e50;--bs-progress-bar-transition: width 0.6s ease;display:flex;display:-webkit-flex;height:var(--bs-progress-height);overflow:hidden;font-size:var(--bs-progress-font-size);background-color:var(--bs-progress-bg);border-radius:var(--bs-progress-border-radius)}.progress-bar{display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;justify-content:center;-webkit-justify-content:center;overflow:hidden;color:var(--bs-progress-bar-color);text-align:center;white-space:nowrap;background-color:var(--bs-progress-bar-bg);transition:var(--bs-progress-bar-transition)}@media (prefers-reduced-motion: reduce){.progress-bar{transition:none}}.progress-bar-striped{background-image:linear-gradient(45deg, rgba(255,255,255,0.15) 25%, transparent 25%, transparent 50%, rgba(255,255,255,0.15) 50%, rgba(255,255,255,0.15) 75%, transparent 75%, transparent);background-size:var(--bs-progress-height) var(--bs-progress-height)}.progress-bar-animated{animation:1s linear infinite progress-bar-stripes}@media (prefers-reduced-motion: reduce){.progress-bar-animated{animation:none}}.list-group{--bs-list-group-color: #212529;--bs-list-group-bg: #fff;--bs-list-group-border-color: rgba(0,0,0,0.125);--bs-list-group-border-width: 1px;--bs-list-group-border-radius: .375rem;--bs-list-group-item-padding-x: 1rem;--bs-list-group-item-padding-y: .5rem;--bs-list-group-action-color: #7b8a8b;--bs-list-group-action-hover-color: #7b8a8b;--bs-list-group-action-hover-bg: #ecf0f1;--bs-list-group-action-active-color: #212529;--bs-list-group-action-active-bg: #ecf0f1;--bs-list-group-disabled-color: #95a5a6;--bs-list-group-disabled-bg: #ecf0f1;--bs-list-group-active-color: #fff;--bs-list-group-active-bg: #2c3e50;--bs-list-group-active-border-color: #2c3e50;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;padding-left:0;margin-bottom:0;border-radius:var(--bs-list-group-border-radius)}.list-group-numbered{list-style-type:none;counter-reset:section}.list-group-numbered>.list-group-item::before{content:counters(section, ".") ". ";counter-increment:section}.list-group-item-action{width:100%;color:var(--bs-list-group-action-color);text-align:inherit}.list-group-item-action:hover,.list-group-item-action:focus{z-index:1;color:var(--bs-list-group-action-hover-color);text-decoration:none;background-color:var(--bs-list-group-action-hover-bg)}.list-group-item-action:active{color:var(--bs-list-group-action-active-color);background-color:var(--bs-list-group-action-active-bg)}.list-group-item{position:relative;display:block;padding:var(--bs-list-group-item-padding-y) var(--bs-list-group-item-padding-x);color:var(--bs-list-group-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-list-group-bg);border:var(--bs-list-group-border-width) solid var(--bs-list-group-border-color)}.list-group-item:first-child{border-top-left-radius:inherit;border-top-right-radius:inherit}.list-group-item:last-child{border-bottom-right-radius:inherit;border-bottom-left-radius:inherit}.list-group-item.disabled,.list-group-item:disabled{color:var(--bs-list-group-disabled-color);pointer-events:none;background-color:var(--bs-list-group-disabled-bg)}.list-group-item.active{z-index:2;color:var(--bs-list-group-active-color);background-color:var(--bs-list-group-active-bg);border-color:var(--bs-list-group-active-border-color)}.list-group-item+.list-group-item{border-top-width:0}.list-group-item+.list-group-item.active{margin-top:calc(-1 * var(--bs-list-group-border-width));border-top-width:var(--bs-list-group-border-width)}.list-group-horizontal{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal>.list-group-item.active{margin-top:0}.list-group-horizontal>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}@media (min-width: 576px){.list-group-horizontal-sm{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-sm>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-sm>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-sm>.list-group-item.active{margin-top:0}.list-group-horizontal-sm>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-sm>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 768px){.list-group-horizontal-md{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-md>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-md>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-md>.list-group-item.active{margin-top:0}.list-group-horizontal-md>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-md>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 992px){.list-group-horizontal-lg{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-lg>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-lg>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-lg>.list-group-item.active{margin-top:0}.list-group-horizontal-lg>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-lg>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 1200px){.list-group-horizontal-xl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xl>.list-group-item.active{margin-top:0}.list-group-horizontal-xl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xl>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 1400px){.list-group-horizontal-xxl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xxl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xxl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xxl>.list-group-item.active{margin-top:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}.list-group-flush{border-radius:0}.list-group-flush>.list-group-item{border-width:0 0 var(--bs-list-group-border-width)}.list-group-flush>.list-group-item:last-child{border-bottom-width:0}.list-group-item-default{color:#596364;background-color:#eaeded}.list-group-item-default.list-group-item-action:hover,.list-group-item-default.list-group-item-action:focus{color:#596364;background-color:#d3d5d5}.list-group-item-default.list-group-item-action.active{color:#fff;background-color:#596364;border-color:#596364}.list-group-item-primary{color:#1a2530;background-color:#d5d8dc}.list-group-item-primary.list-group-item-action:hover,.list-group-item-primary.list-group-item-action:focus{color:#1a2530;background-color:#c0c2c6}.list-group-item-primary.list-group-item-action.active{color:#fff;background-color:#1a2530;border-color:#1a2530}.list-group-item-secondary{color:#596364;background-color:#eaeded}.list-group-item-secondary.list-group-item-action:hover,.list-group-item-secondary.list-group-item-action:focus{color:#596364;background-color:#d3d5d5}.list-group-item-secondary.list-group-item-action.active{color:#fff;background-color:#596364;border-color:#596364}.list-group-item-success{color:#0b5647;background-color:#d0e9e4}.list-group-item-success.list-group-item-action:hover,.list-group-item-success.list-group-item-action:focus{color:#0b5647;background-color:#bbd2cd}.list-group-item-success.list-group-item-action.active{color:#fff;background-color:#0b5647;border-color:#0b5647}.list-group-item-info{color:#3a645c;background-color:#dfedeb}.list-group-item-info.list-group-item-action:hover,.list-group-item-info.list-group-item-action:focus{color:#3a645c;background-color:#c9d5d4}.list-group-item-info.list-group-item-action.active{color:#fff;background-color:#3a645c;border-color:#3a645c}.list-group-item-warning{color:#925e0b;background-color:#fdebd0}.list-group-item-warning.list-group-item-action:hover,.list-group-item-warning.list-group-item-action:focus{color:#925e0b;background-color:#e4d4bb}.list-group-item-warning.list-group-item-action.active{color:#fff;background-color:#925e0b;border-color:#925e0b}.list-group-item-danger{color:#8b2e24;background-color:#fadbd8}.list-group-item-danger.list-group-item-action:hover,.list-group-item-danger.list-group-item-action:focus{color:#8b2e24;background-color:#e1c5c2}.list-group-item-danger.list-group-item-action.active{color:#fff;background-color:#8b2e24;border-color:#8b2e24}.list-group-item-light{color:rgba(8,60,50,0.790588);background-color:rgba(229,243,240,0.930196)}.list-group-item-light.list-group-item-action:hover,.list-group-item-light.list-group-item-action:focus{color:rgba(8,60,50,0.790588);background-color:rgba(203,215,213,0.937176)}.list-group-item-light.list-group-item-action.active{color:#fff;background-color:rgba(8,60,50,0.790588);border-color:rgba(8,60,50,0.790588)}.list-group-item-dark{color:#4a5353;background-color:#e5e8e8}.list-group-item-dark.list-group-item-action:hover,.list-group-item-dark.list-group-item-action:focus{color:#4a5353;background-color:#ced1d1}.list-group-item-dark.list-group-item-action.active{color:#fff;background-color:#4a5353;border-color:#4a5353}.btn-close{box-sizing:content-box;width:1em;height:1em;padding:.25em .25em;color:#fff;background:transparent url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23fff'%3e%3cpath d='M.293.293a1 1 0 0 1 1.414 0L8 6.586 14.293.293a1 1 0 1 1 1.414 1.414L9.414 8l6.293 6.293a1 1 0 0 1-1.414 1.414L8 9.414l-6.293 6.293a1 1 0 0 1-1.414-1.414L6.586 8 .293 1.707a1 1 0 0 1 0-1.414z'/%3e%3c/svg%3e") center/1em auto no-repeat;border:0;border-radius:.375rem;opacity:.4}.btn-close:hover{color:#fff;text-decoration:none;opacity:1}.btn-close:focus{outline:0;box-shadow:0 0 0 .25rem rgba(44,62,80,0.25);opacity:1}.btn-close:disabled,.btn-close.disabled{pointer-events:none;user-select:none;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;opacity:.25}.btn-close-white{filter:invert(1) grayscale(100%) brightness(200%)}.toast{--bs-toast-zindex: 1090;--bs-toast-padding-x: .75rem;--bs-toast-padding-y: .5rem;--bs-toast-spacing: 1.5rem;--bs-toast-max-width: 350px;--bs-toast-font-size:.875rem;--bs-toast-color: ;--bs-toast-bg: rgba(255,255,255,0.85);--bs-toast-border-width: 1px;--bs-toast-border-color: var(--bs-border-color-translucent);--bs-toast-border-radius: .375rem;--bs-toast-box-shadow: 0 0.5rem 1rem rgba(0,0,0,0.15);--bs-toast-header-color: #95a5a6;--bs-toast-header-bg: rgba(255,255,255,0.85);--bs-toast-header-border-color: rgba(0,0,0,0.05);width:var(--bs-toast-max-width);max-width:100%;font-size:var(--bs-toast-font-size);color:var(--bs-toast-color);pointer-events:auto;background-color:var(--bs-toast-bg);background-clip:padding-box;border:var(--bs-toast-border-width) solid var(--bs-toast-border-color);box-shadow:var(--bs-toast-box-shadow);border-radius:var(--bs-toast-border-radius)}.toast.showing{opacity:0}.toast:not(.show){display:none}.toast-container{--bs-toast-zindex: 1090;position:absolute;z-index:var(--bs-toast-zindex);width:max-content;width:-webkit-max-content;width:-moz-max-content;width:-ms-max-content;width:-o-max-content;max-width:100%;pointer-events:none}.toast-container>:not(:last-child){margin-bottom:var(--bs-toast-spacing)}.toast-header{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;padding:var(--bs-toast-padding-y) var(--bs-toast-padding-x);color:var(--bs-toast-header-color);background-color:var(--bs-toast-header-bg);background-clip:padding-box;border-bottom:var(--bs-toast-border-width) solid var(--bs-toast-header-border-color);border-top-left-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width));border-top-right-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width))}.toast-header .btn-close{margin-right:calc(-.5 * var(--bs-toast-padding-x));margin-left:var(--bs-toast-padding-x)}.toast-body{padding:var(--bs-toast-padding-x);word-wrap:break-word}.modal{--bs-modal-zindex: 1055;--bs-modal-width: 500px;--bs-modal-padding: 1rem;--bs-modal-margin: .5rem;--bs-modal-color: ;--bs-modal-bg: #fff;--bs-modal-border-color: var(--bs-border-color-translucent);--bs-modal-border-width: 1px;--bs-modal-border-radius: .5rem;--bs-modal-box-shadow: 0 0.125rem 0.25rem rgba(0,0,0,0.075);--bs-modal-inner-border-radius: calc(.5rem - 1px);--bs-modal-header-padding-x: 1rem;--bs-modal-header-padding-y: 1rem;--bs-modal-header-padding: 1rem 1rem;--bs-modal-header-border-color: var(--bs-border-color);--bs-modal-header-border-width: 1px;--bs-modal-title-line-height: 1.75;--bs-modal-footer-gap: .5rem;--bs-modal-footer-bg: ;--bs-modal-footer-border-color: var(--bs-border-color);--bs-modal-footer-border-width: 1px;position:fixed;top:0;left:0;z-index:var(--bs-modal-zindex);display:none;width:100%;height:100%;overflow-x:hidden;overflow-y:auto;outline:0}.modal-dialog{position:relative;width:auto;margin:var(--bs-modal-margin);pointer-events:none}.modal.fade .modal-dialog{transition:transform 0.3s ease-out;transform:translate(0, -50px)}@media (prefers-reduced-motion: reduce){.modal.fade .modal-dialog{transition:none}}.modal.show .modal-dialog{transform:none}.modal.modal-static .modal-dialog{transform:scale(1.02)}.modal-dialog-scrollable{height:calc(100% - var(--bs-modal-margin) * 2)}.modal-dialog-scrollable .modal-content{max-height:100%;overflow:hidden}.modal-dialog-scrollable .modal-body{overflow-y:auto}.modal-dialog-centered{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;min-height:calc(100% - var(--bs-modal-margin) * 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var(--bs-accordion-border-color)}.accordion-item:first-of-type{border-top-left-radius:var(--bs-accordion-border-radius);border-top-right-radius:var(--bs-accordion-border-radius)}.accordion-item:first-of-type .accordion-button{border-top-left-radius:var(--bs-accordion-inner-border-radius);border-top-right-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:not(:first-of-type){border-top:0}.accordion-item:last-of-type{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-item:last-of-type .accordion-button.collapsed{border-bottom-right-radius:var(--bs-accordion-inner-border-radius);border-bottom-left-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:last-of-type .accordion-collapse{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-body{padding:var(--bs-accordion-body-padding-y) var(--bs-accordion-body-padding-x)}.accordion-flush .accordion-collapse,.bslib-sidebar-layout>.sidebar>.sidebar-content>.accordion .accordion-collapse{border-width:0}.accordion-flush .accordion-item,.bslib-sidebar-layout>.sidebar>.sidebar-content>.accordion .accordion-item{border-right:0;border-left:0;border-radius:0}.accordion-flush .accordion-item:first-child,.bslib-sidebar-layout>.sidebar>.sidebar-content>.accordion .accordion-item:first-child{border-top:0}.accordion-flush .accordion-item:last-child,.bslib-sidebar-layout>.sidebar>.sidebar-content>.accordion .accordion-item:last-child{border-bottom:0}.accordion-flush .accordion-item .accordion-button,.bslib-sidebar-layout>.sidebar>.sidebar-content>.accordion .accordion-item .accordion-button,.accordion-flush .accordion-item .accordion-button.collapsed{border-radius:0}.breadcrumb{--bs-breadcrumb-padding-x: .75rem;--bs-breadcrumb-padding-y: .375rem;--bs-breadcrumb-margin-bottom: 1rem;--bs-breadcrumb-bg: ;--bs-breadcrumb-border-radius: .25rem;--bs-breadcrumb-divider-color: #95a5a6;--bs-breadcrumb-item-padding-x: .5rem;--bs-breadcrumb-item-active-color: #95a5a6;display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding:var(--bs-breadcrumb-padding-y) var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);list-style:none;background-color:var(--bs-breadcrumb-bg);border-radius:var(--bs-breadcrumb-border-radius)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, "/") /* rtl: var(--bs-breadcrumb-divider, "/") */}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.pagination{--bs-pagination-padding-x: .75rem;--bs-pagination-padding-y: .375rem;--bs-pagination-font-size:1rem;--bs-pagination-color: #fff;--bs-pagination-bg: #128F76;--bs-pagination-border-width: 0;--bs-pagination-border-color: rgba(0,0,0,0);--bs-pagination-border-radius: .375rem;--bs-pagination-hover-color: #fff;--bs-pagination-hover-bg: #094b3e;--bs-pagination-hover-border-color: rgba(0,0,0,0);--bs-pagination-focus-color: var(--bs-link-hover-color);--bs-pagination-focus-bg: #ecf0f1;--bs-pagination-focus-box-shadow: 0 0 0 .25rem rgba(44,62,80,0.25);--bs-pagination-active-color: #fff;--bs-pagination-active-bg: #094b3e;--bs-pagination-active-border-color: rgba(0,0,0,0);--bs-pagination-disabled-color: #ecf0f1;--bs-pagination-disabled-bg: #1bd3ae;--bs-pagination-disabled-border-color: rgba(0,0,0,0);display:flex;display:-webkit-flex;padding-left:0;list-style:none}.page-link{position:relative;display:block;padding:var(--bs-pagination-padding-y) 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.badge{position:relative;top:-1px}.alert{--bs-alert-bg: transparent;--bs-alert-padding-x: 1rem;--bs-alert-padding-y: 1rem;--bs-alert-margin-bottom: 1rem;--bs-alert-color: inherit;--bs-alert-border-color: transparent;--bs-alert-border: 1px solid var(--bs-alert-border-color);--bs-alert-border-radius: .375rem;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border);border-radius:var(--bs-alert-border-radius)}.alert-heading{color:inherit}.alert-link{font-weight:700}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-default{--bs-alert-color: #596364;--bs-alert-bg: #eaeded;--bs-alert-border-color: #dfe4e4}.alert-default .alert-link{color:#474f50}.alert-primary{--bs-alert-color: #1a2530;--bs-alert-bg: #d5d8dc;--bs-alert-border-color: 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#95a5a6;--bs-list-group-disabled-bg: #ecf0f1;--bs-list-group-active-color: #fff;--bs-list-group-active-bg: #2c3e50;--bs-list-group-active-border-color: #2c3e50;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;padding-left:0;margin-bottom:0;border-radius:var(--bs-list-group-border-radius)}.list-group-numbered{list-style-type:none;counter-reset:section}.list-group-numbered>.list-group-item::before{content:counters(section, ".") 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";counter-increment:section}.list-group-item-action{width:100%;color:var(--bs-list-group-action-color);text-align:inherit}.list-group-item-action:hover,.list-group-item-action:focus{z-index:1;color:var(--bs-list-group-action-hover-color);text-decoration:none;background-color:var(--bs-list-group-action-hover-bg)}.list-group-item-action:active{color:var(--bs-list-group-action-active-color);background-color:var(--bs-list-group-action-active-bg)}.list-group-item{position:relative;display:block;padding:var(--bs-list-group-item-padding-y) var(--bs-list-group-item-padding-x);color:var(--bs-list-group-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-list-group-bg);border:var(--bs-list-group-border-width) solid var(--bs-list-group-border-color)}.list-group-item:first-child{border-top-left-radius:inherit;border-top-right-radius:inherit}.list-group-item:last-child{border-bottom-right-radius:inherit;border-bottom-left-radius:inherit}.list-group-item.disabled,.list-group-item:disabled{color:var(--bs-list-group-disabled-color);pointer-events:none;background-color:var(--bs-list-group-disabled-bg)}.list-group-item.active{z-index:2;color:var(--bs-list-group-active-color);background-color:var(--bs-list-group-active-bg);border-color:var(--bs-list-group-active-border-color)}.list-group-item+.list-group-item{border-top-width:0}.list-group-item+.list-group-item.active{margin-top:calc(-1 * var(--bs-list-group-border-width));border-top-width:var(--bs-list-group-border-width)}.list-group-horizontal{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal>.list-group-item.active{margin-top:0}.list-group-horizontal>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}@media (min-width: 576px){.list-group-horizontal-sm{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-sm>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-sm>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-sm>.list-group-item.active{margin-top:0}.list-group-horizontal-sm>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-sm>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 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1200px){.list-group-horizontal-xl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xl>.list-group-item.active{margin-top:0}.list-group-horizontal-xl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xl>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 1400px){.list-group-horizontal-xxl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xxl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xxl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xxl>.list-group-item.active{margin-top:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}.list-group-flush{border-radius:0}.list-group-flush>.list-group-item{border-width:0 0 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.25em;color:#fff;background:transparent url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23fff'%3e%3cpath d='M.293.293a1 1 0 0 1 1.414 0L8 6.586 14.293.293a1 1 0 1 1 1.414 1.414L9.414 8l6.293 6.293a1 1 0 0 1-1.414 1.414L8 9.414l-6.293 6.293a1 1 0 0 1-1.414-1.414L6.586 8 .293 1.707a1 1 0 0 1 0-1.414z'/%3e%3c/svg%3e") center/1em auto no-repeat;border:0;border-radius:.375rem;opacity:.4}.btn-close:hover{color:#fff;text-decoration:none;opacity:1}.btn-close:focus{outline:0;box-shadow:0 0 0 .25rem rgba(44,62,80,0.25);opacity:1}.btn-close:disabled,.btn-close.disabled{pointer-events:none;user-select:none;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;opacity:.25}.btn-close-white{filter:invert(1) grayscale(100%) brightness(200%)}.toast{--bs-toast-zindex: 1090;--bs-toast-padding-x: .75rem;--bs-toast-padding-y: .5rem;--bs-toast-spacing: 1.5rem;--bs-toast-max-width: 350px;--bs-toast-font-size:.875rem;--bs-toast-color: ;--bs-toast-bg: rgba(255,255,255,0.85);--bs-toast-border-width: 1px;--bs-toast-border-color: var(--bs-border-color-translucent);--bs-toast-border-radius: .375rem;--bs-toast-box-shadow: 0 0.5rem 1rem rgba(0,0,0,0.15);--bs-toast-header-color: #95a5a6;--bs-toast-header-bg: rgba(255,255,255,0.85);--bs-toast-header-border-color: rgba(0,0,0,0.05);width:var(--bs-toast-max-width);max-width:100%;font-size:var(--bs-toast-font-size);color:var(--bs-toast-color);pointer-events:auto;background-color:var(--bs-toast-bg);background-clip:padding-box;border:var(--bs-toast-border-width) solid var(--bs-toast-border-color);box-shadow:var(--bs-toast-box-shadow);border-radius:var(--bs-toast-border-radius)}.toast.showing{opacity:0}.toast:not(.show){display:none}.toast-container{--bs-toast-zindex: 1090;position:absolute;z-index:var(--bs-toast-zindex);width:max-content;width:-webkit-max-content;width:-moz-max-content;width:-ms-max-content;width:-o-max-content;max-width:100%;pointer-events:none}.toast-container>:not(:last-child){margin-bottom:var(--bs-toast-spacing)}.toast-header{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;padding:var(--bs-toast-padding-y) var(--bs-toast-padding-x);color:var(--bs-toast-header-color);background-color:var(--bs-toast-header-bg);background-clip:padding-box;border-bottom:var(--bs-toast-border-width) solid var(--bs-toast-header-border-color);border-top-left-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width));border-top-right-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width))}.toast-header .btn-close{margin-right:calc(-.5 * var(--bs-toast-padding-x));margin-left:var(--bs-toast-padding-x)}.toast-body{padding:var(--bs-toast-padding-x);word-wrap:break-word}.modal{--bs-modal-zindex: 1055;--bs-modal-width: 500px;--bs-modal-padding: 1rem;--bs-modal-margin: .5rem;--bs-modal-color: ;--bs-modal-bg: #fff;--bs-modal-border-color: var(--bs-border-color-translucent);--bs-modal-border-width: 1px;--bs-modal-border-radius: .5rem;--bs-modal-box-shadow: 0 0.125rem 0.25rem rgba(0,0,0,0.075);--bs-modal-inner-border-radius: calc(.5rem - 1px);--bs-modal-header-padding-x: 1rem;--bs-modal-header-padding-y: 1rem;--bs-modal-header-padding: 1rem 1rem;--bs-modal-header-border-color: var(--bs-border-color);--bs-modal-header-border-width: 1px;--bs-modal-title-line-height: 1.75;--bs-modal-footer-gap: .5rem;--bs-modal-footer-bg: ;--bs-modal-footer-border-color: var(--bs-border-color);--bs-modal-footer-border-width: 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zero dependencies to simplify the analysis and prediction of Antimicrobial Resistance (AMR) and to work with microbial and antimicrobial data and properties, by using evidence-based methods. Our aim is to provide a standard for clean and reproducible AMR data analysis, that can therefore empower epidemiological analyses to continuously enable surveillance and treatment evaluation in any setting. Many different researchers from around the globe are continually helping us to make this a successful and durable project! This work was published in the Journal of Statistical Software (Volume 104(3); DOI 10.18637/jss.v104.i03) and formed the basis of two PhD theses (DOI 10.33612/diss.177417131 and DOI 10.33612/diss.192486375). -After installing this package, R knows ~52,000 distinct microbial species (updated December 2022) and all ~600 antibiotic, antimycotic and antiviral drugs by name and code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC and SNOMED CT), and knows all about valid SIR and MIC values. The integral breakpoint guidelines from CLSI and EUCAST are included from the last 10 years. It supports and can read any data format, including WHONET data. This package works on Windows, macOS and Linux with all versions of R since R-3.0 (April 2013). It was designed to work in any setting, including those with very limited resources. It was created for both routine data analysis and academic research at the Faculty of Medical Sciences of the University of Groningen, in collaboration with non-profit organisations Certe Medical Diagnostics and Advice Foundation and University Medical Center Groningen. +After installing this package, R knows ~52,000 distinct microbial species (updated December 2022) and all ~600 antibiotic, antimycotic and antiviral drugs by name and code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC and SNOMED CT), and knows all about valid SIR and MIC values. The integral clinical breakpoint guidelines from CLSI and EUCAST are included, even with epidemiological cut-off (ECOFF) values. It supports and can read any data format, including WHONET data. This package works on Windows, macOS and Linux with all versions of R since R-3.0 (April 2013). It was designed to work in any setting, including those with very limited resources. It was created for both routine data analysis and academic research at the Faculty of Medical Sciences of the University of Groningen, in collaboration with non-profit organisations Certe Medical Diagnostics and Advice Foundation and University Medical Center Groningen. Used in over 175 countries, translated into 20 languages @@ -738,7 +738,7 @@ This package was intended as a comprehensive toolbox for integrated AMR data analysis. This package can be used for: Reference for the taxonomy of microorganisms, since the package contains all microbial (sub)species from the List of Prokaryotic names with Standing in Nomenclature (LPSN) and the Global Biodiversity Information Facility (GBIF) (manual) -Interpreting raw MIC and disk diffusion values, based on any CLSI or EUCAST guideline from the last 10 years (manual) +Interpreting raw MIC and disk diffusion values, based on any CLSI or EUCAST guideline (manual) Retrieving antimicrobial drug names, doses and forms of administration from clinical health care records (manual) Determining first isolates to be used for AMR data analysis (manual) Calculating antimicrobial resistance (tutorial) @@ -779,7 +779,7 @@ Manually, using: install.packages("remotes") # if you haven't already -remotes::install_github("msberends/AMR") +remotes::install_github("msberends/AMR") Automatically, using the rOpenSci R-universe platform, by adding our R-universe address to your list of repositories (‘repos’): diff --git a/news/index.html b/news/index.html index 8a1cea99..25f416d3 100644 --- a/news/index.html +++ b/news/index.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 @@ -159,10 +159,13 @@ -AMR 2.0.0.9023 +AMR 2.0.0.9024 -Changed -Added oxygen tolerance from BacDive to over 25,000 bacteria in the microorganisms data set +New +Clinical breakpoints and intrinsic resistance of EUCAST 2023 and CLSI 2023 have been added for as.sir(). EUCAST 2023 (v13.0) is now the new default guideline for all MIC and disks diffusion interpretations, and for eucast_rules() to apply EUCAST Expert Rules. +The EUCAST dosage guideline of v13.0 has been added to the dosage data set +ECOFF: the clinical_breakpoints data set now contains the new column ecoff, in which the epidemiological cut-off (ECOFF) are available. These ECOFFs can be used for MIC/disk interpretation using as.sir(..., ecoff = TRUE), which is an important new addition for veterinary microbiology. +Added oxygen tolerance from BacDive to over 25,000 bacteria in the microorganisms data set Added mo_oxygen_tolerance() to retrieve the values Added mo_is_anaerobic() to determine which genera/species are obligate anaerobic bacteria @@ -170,7 +173,10 @@ Added SAS Transport files (file extension .xpt) to our download page to use in SAS software Added microbial codes for Gram-negative/positive anaerobic bacteria - + + +Changed + mo_rank() now returns NA for ‘unknown’ microorganisms (B_ANAER, B_ANAER-NEG, B_ANAER-POS, B_GRAMN, B_GRAMP, F_FUNGUS, F_YEAST, and UNKNOWN) Fixed formatting for sir_interpretation_history() @@ -179,7 +185,11 @@ Fixed a bug for as.mo() that led to coercion of NA values when using custom microorganism codes Fixed usage of icu_exclude in first_isolates() -Improved as.mo() algorithm for searching on only species names +Improved as.mo() algorithm: +Now allows searching on only species names +Fix for using the keep_synonyms argument when using MO codes as input +Fix for using the minimum_matching_score argument + Updated the code table in microorganisms.codes diff --git a/pkgdown.yml b/pkgdown.yml index cd7d5e13..4758f2c9 100644 --- a/pkgdown.yml +++ b/pkgdown.yml @@ -11,7 +11,7 @@ articles: other_pkg: other_pkg.html resistance_predict: resistance_predict.html welcome_to_AMR: welcome_to_AMR.html -last_built: 2023-05-27T08:50Z +last_built: 2023-06-22T13:15Z urls: reference: https://msberends.github.io/AMR/reference article: https://msberends.github.io/AMR/articles diff --git a/reference/AMR-deprecated.html b/reference/AMR-deprecated.html index 2e803f85..ad07454d 100644 --- a/reference/AMR-deprecated.html +++ b/reference/AMR-deprecated.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/AMR-options.html b/reference/AMR-options.html index 557ccc8c..1d0f172b 100644 --- a/reference/AMR-options.html +++ b/reference/AMR-options.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 @@ -171,9 +171,10 @@ AMR_custom_ab Allows to use custom antimicrobial drugs with this package. This is explained in add_custom_antimicrobials(). AMR_custom_mo Allows to use custom microorganisms with this package. This is explained in add_custom_microorganisms(). AMR_eucastrules Used for setting the default types of rules for eucast_rules() function, must be one or more of: "breakpoints", "expert", "other", "custom", "all", and defaults to c("breakpoints", "expert"). -AMR_guideline Used for setting the default guideline for interpreting MIC values and disk diffusion diameters with as.sir(). Can be only the guideline name (e.g., "CLSI") or the name with a year (e.g. "CLSI 2019"). The default to the latest implemented EUCAST guideline, currently "EUCAST 2022". Supported guideline are currently EUCAST (2013-2022) and CLSI (2013-2022). +AMR_guideline Used for setting the default guideline for interpreting MIC values and disk diffusion diameters with as.sir(). Can be only the guideline name (e.g., "CLSI") or the name with a year (e.g. "CLSI 2019"). The default to the latest implemented EUCAST guideline, currently "EUCAST 2023". Supported guideline are currently EUCAST (2011-2023) and CLSI (2011-2023). AMR_ignore_pattern A regular expression to ignore (i.e., make NA) any match given in as.mo() and all mo_* functions. AMR_include_PKPD A logical to use in as.sir(), to indicate that PK/PD clinical breakpoints must be applied as a last resort - the default is TRUE. +AMR_ecoff A logical use in as.sir(), to indicate that ECOFF (Epidemiological Cut-Off) values must be used - the default is FALSE. AMR_include_screening A logical to use in as.sir(), to indicate that clinical breakpoints for screening are allowed - the default is FALSE. AMR_keep_synonyms A logical to use in as.mo() and all mo_* functions, to indicate if old, previously valid taxonomic names must be preserved and not be corrected to currently accepted names. The default is FALSE. AMR_cleaning_regex A regular expression (case-insensitive) to use in as.mo() and all mo_* functions, to clean the user input. The default is the outcome of mo_cleaning_regex(), which removes texts between brackets and texts such as "species" and "serovar". diff --git a/reference/AMR.html b/reference/AMR.html index fd5f416e..86ecbb8f 100644 --- a/reference/AMR.html +++ b/reference/AMR.html @@ -5,14 +5,14 @@ This work was published in the Journal of Statistical Software (Volume 104(3); d ) and formed the basis of two PhD theses (doi:10.33612/diss.177417131 and doi:10.33612/diss.192486375 ). -After installing this package, R knows ~52 000 microorganisms (updated December 2022) and all ~600 antibiotic, antimycotic and antiviral drugs by name and code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC and SNOMED CT), and knows all about valid SIR and MIC values. The integral breakpoint guidelines from CLSI and EUCAST are included from the last 10 years. It supports and can read any data format, including WHONET data. This package works on Windows, macOS and Linux with all versions of R since R-3.0 (April 2013). It was designed to work in any setting, including those with very limited resources. It was created for both routine data analysis and academic research at the Faculty of Medical Sciences of the University of Groningen, in collaboration with non-profit organisations Certe Medical Diagnostics and Advice Foundation and University Medical Center Groningen. +After installing this package, R knows ~52 000 microorganisms (updated December 2022) and all ~600 antibiotic, antimycotic and antiviral drugs by name and code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC and SNOMED CT), and knows all about valid SIR and MIC values. The integral clinical breakpoint guidelines from CLSI and EUCAST are included, even with epidemiological cut-off (ECOFF) values. It supports and can read any data format, including WHONET data. This package works on Windows, macOS and Linux with all versions of R since R-3.0 (April 2013). It was designed to work in any setting, including those with very limited resources. It was created for both routine data analysis and academic research at the Faculty of Medical Sciences of the University of Groningen, in collaboration with non-profit organisations Certe Medical Diagnostics and Advice Foundation and University Medical Center Groningen. The AMR package is available in English, Chinese, Czech, Danish, Dutch, Finnish, French, German, Greek, Italian, Japanese, Norwegian, Polish, Portuguese, Romanian, Russian, Spanish, Swedish, Turkish, and Ukrainian. Antimicrobial drug (group) names and colloquial microorganism names are provided in these languages.">The AMR Package — AMR • AMR (for R)Data Set with Clinical Breakpoints for SIR Interpretation — clinical_breakpoints • AMR (for R)Data Set with Clinical Breakpoints for SIR Interpretation — clinical_breakpoints • AMR (for R) @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 @@ -160,7 +160,7 @@ - Data set containing clinical breakpoints to interpret MIC and disk diffusion to SIR values, according to international guidelines. Currently implemented guidelines are EUCAST (2013-2022) and CLSI (2013-2022). Use as.sir() to transform MICs or disks measurements to SIR values. + Data set containing clinical breakpoints to interpret MIC and disk diffusion to SIR values, according to international guidelines. Currently implemented guidelines are EUCAST (2011-2023) and CLSI (2011-2023). Use as.sir() to transform MICs or disks measurements to SIR values. @@ -170,7 +170,7 @@ Format - A tibble with 18 271 observations and 11 variables:guideline Name of the guideline + A tibble with 42 599 observations and 12 variables:guideline Name of the guideline method Either "DISK" or "MIC" site Body site, e.g. "Oral" or "Respiratory" mo Microbial ID, see as.mo() @@ -180,11 +180,13 @@ disk_dose Dose of the used disk diffusion method breakpoint_S Lowest MIC value or highest number of millimetres that leads to "S" breakpoint_R Highest MIC value or lowest number of millimetres that leads to "R" +ecoff Epidemiological cut-off (ECOFF) value, used in antimicrobial susceptibility testing to differentiate between wild-type and non-wild-type strains of bacteria or fungi (use as.sir(..., ecoff = TRUE) to interpret raw data using ECOFF values) uti A logical value (TRUE/FALSE) to indicate whether the rule applies to a urinary tract infection (UTI) Details - Like all data sets in this package, this data set is publicly available for download in the following formats: R, MS Excel, Apache Feather, Apache Parquet, SPSS, SAS, and Stata. Please visit our website for the download links. The actual files are of course available on our GitHub repository. + Clinical breakpoints are validated through WHONET, a free desktop Windows application developed and supported by the WHO Collaborating Centre for Surveillance of Antimicrobial Resistance. More can be read on their website. +Like all data sets in this package, this data set is publicly available for download in the following formats: R, MS Excel, Apache Feather, Apache Parquet, SPSS, SAS, and Stata. Please visit our website for the download links. The actual files are of course available on our GitHub repository. They allow for machine reading EUCAST and CLSI guidelines, which is almost impossible with the MS Excel and PDF files distributed by EUCAST and CLSI. @@ -195,21 +197,22 @@ Examples clinical_breakpoints -#> # A tibble: 18,271 × 11 -#> guideline method site mo rank_index ab ref_tbl disk_dose -#> <chr> <chr> <chr> <mo> <dbl> <ab> <chr> <chr> -#> 1 EUCAST 2022 MIC NA F_ASPRG_MGTS 2 AMB Aspergil… NA -#> 2 EUCAST 2022 MIC NA F_ASPRG_NIGR 2 AMB Aspergil… NA -#> 3 EUCAST 2022 MIC NA F_CANDD_ALBC 2 AMB Candida NA -#> 4 EUCAST 2022 MIC NA F_CANDD_DBLN 2 AMB Candida NA -#> 5 EUCAST 2022 MIC NA F_CANDD_GLBR 2 AMB Candida NA -#> 6 EUCAST 2022 MIC NA F_CANDD_KRUS 2 AMB Candida NA -#> 7 EUCAST 2022 MIC NA F_CANDD_PRPS 2 AMB Candida NA -#> 8 EUCAST 2022 MIC NA F_CANDD_TRPC 2 AMB Candida NA -#> 9 EUCAST 2022 MIC NA F_CRYPT_NFRM 2 AMB Candida NA -#> 10 EUCAST 2022 DISK NA B_[ORD]_ENTRBCTR 5 AMC Enteroba… 20ug/10ug -#> # ℹ 18,261 more rows -#> # ℹ 3 more variables: breakpoint_S <dbl>, breakpoint_R <dbl>, uti <lgl> +#> # A tibble: 42,599 × 12 +#> guideline method site mo rank_index ab ref_tbl disk_dose +#> <chr> <chr> <chr> <mo> <dbl> <ab> <chr> <chr> +#> 1 EUCAST 2023 MIC NA F_ASPRG_MGTS 2 AMB Aspergillus NA +#> 2 EUCAST 2023 MIC NA F_ASPRG_NIGR 2 AMB Aspergillus NA +#> 3 EUCAST 2023 MIC NA F_CANDD_ALBC 2 AMB Candida NA +#> 4 EUCAST 2023 MIC NA F_CANDD_DBLN 2 AMB Candida NA +#> 5 EUCAST 2023 MIC NA F_CANDD_GLBR 2 AMB Candida NA +#> 6 EUCAST 2023 MIC NA F_CANDD_KRUS 2 AMB Candida NA +#> 7 EUCAST 2023 MIC NA F_CANDD_PRPS 2 AMB Candida NA +#> 8 EUCAST 2023 MIC NA F_CANDD_TRPC 2 AMB Candida NA +#> 9 EUCAST 2023 MIC NA F_CRYPT_NFRM 2 AMB Candida NA +#> 10 EUCAST 2023 MIC NA B_ANAER-NEG 6 AMC Gram-negativ… NA +#> # ℹ 42,589 more rows +#> # ℹ 4 more variables: breakpoint_S <dbl>, breakpoint_R <dbl>, ecoff <dbl>, +#> # uti <lgl> +eucast_dosage(ab, administration = "iv", version_breakpoints = 13) @@ -221,11 +222,15 @@ Leclercq et al. EUCAST expert rules in antimicrobial susceptibility test version_breakpoints -the version number to use for the EUCAST Clinical Breakpoints guideline. Can be either "12.0", "11.0", or "10.0". +the version number to use for the EUCAST Clinical Breakpoints guideline. Can be "13.0", "12.0", "11.0", or "10.0". version_expertrules -the version number to use for the EUCAST Expert Rules and Intrinsic Resistance guideline. Can be either "3.3", "3.2", or "3.1". +the version number to use for the EUCAST Expert Rules and Intrinsic Resistance guideline. Can be "3.3", "3.2", or "3.1". + + +version_resistant_phenotypes +the version number to use for the EUCAST Expected Resistant Phenotypes. Can be "1.2". ampc_cephalosporin_resistance @@ -381,7 +386,7 @@ Leclercq et al. EUCAST expert rules in antimicrobial susceptibility test eucast_dosage(c("tobra", "genta", "cipro"), "iv") #> ℹ Dosages for antimicrobial drugs, as meant for 'EUCAST Clinical Breakpoint -#> Tables' v12.0 (2022). This note will be shown once per session. +#> Tables' v13.0 (2023). This note will be shown once per session. #> # A tibble: 3 × 4 #> ab name standard_dosage high_dosage #> <ab> <chr> <chr> <chr> diff --git a/reference/example_isolates.html b/reference/example_isolates.html index 14afa39e..dc4a055c 100644 --- a/reference/example_isolates.html +++ b/reference/example_isolates.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/example_isolates_unclean.html b/reference/example_isolates_unclean.html index a2624a12..d769f107 100644 --- a/reference/example_isolates_unclean.html +++ b/reference/example_isolates_unclean.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/first_isolate.html b/reference/first_isolate.html index b0914b9b..7ca9b946 100644 --- a/reference/first_isolate.html +++ b/reference/first_isolate.html @@ -12,7 +12,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/g.test.html b/reference/g.test.html index 38d0042c..b2a6e6eb 100644 --- a/reference/g.test.html +++ b/reference/g.test.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/get_episode.html b/reference/get_episode.html index 98dac5d3..5589b938 100644 --- a/reference/get_episode.html +++ b/reference/get_episode.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 @@ -263,27 +263,29 @@ df <- example_isolates[sample(seq_len(2000), size = 100), ] get_episode(df$date, episode_days = 60) # indices -#> [1] 34 32 18 15 11 8 45 29 7 7 46 31 27 44 20 38 47 11 42 3 46 4 13 37 4 -#> [26] 9 35 5 46 26 44 40 16 20 21 20 24 27 14 41 20 41 28 27 42 24 22 35 30 22 -#> [51] 16 44 25 35 30 6 12 13 38 8 33 46 29 6 23 6 34 47 11 1 16 40 27 46 5 -#> [76] 10 2 39 48 4 23 46 25 36 19 12 43 17 22 9 47 11 2 45 17 15 42 37 28 8 +#> [1] 12 24 43 42 22 36 23 19 6 36 30 18 2 25 41 27 13 45 31 16 4 6 21 29 18 +#> [26] 10 29 30 35 28 9 2 14 31 38 24 20 33 37 35 33 9 46 23 1 44 30 2 48 3 +#> [51] 41 17 31 40 36 40 17 43 42 38 8 36 40 3 47 29 34 37 10 43 6 7 22 32 10 +#> [76] 31 12 14 34 39 1 35 42 45 26 11 38 5 15 3 28 39 45 8 15 9 7 1 41 32 is_new_episode(df$date, episode_days = 60) # TRUE/FALSE #> [1] TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE TRUE -#> [13] TRUE TRUE TRUE TRUE TRUE FALSE TRUE TRUE FALSE TRUE TRUE TRUE -#> [25] FALSE TRUE TRUE TRUE FALSE TRUE FALSE TRUE TRUE FALSE TRUE FALSE -#> [37] TRUE FALSE TRUE TRUE FALSE FALSE TRUE FALSE FALSE FALSE TRUE FALSE -#> [49] TRUE FALSE FALSE FALSE TRUE FALSE FALSE TRUE TRUE FALSE FALSE FALSE -#> [61] TRUE FALSE FALSE FALSE TRUE FALSE FALSE FALSE FALSE TRUE FALSE FALSE -#> [73] FALSE FALSE FALSE TRUE TRUE TRUE TRUE FALSE FALSE FALSE FALSE TRUE -#> [85] TRUE FALSE TRUE TRUE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE +#> [13] TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE TRUE FALSE TRUE TRUE +#> [25] FALSE TRUE FALSE FALSE TRUE TRUE TRUE FALSE TRUE FALSE TRUE FALSE +#> [37] TRUE TRUE TRUE FALSE FALSE FALSE TRUE FALSE TRUE TRUE FALSE FALSE +#> [49] TRUE TRUE FALSE TRUE FALSE TRUE FALSE FALSE FALSE FALSE FALSE FALSE +#> [61] TRUE FALSE FALSE FALSE TRUE FALSE TRUE FALSE FALSE FALSE FALSE TRUE +#> [73] FALSE TRUE FALSE FALSE FALSE FALSE FALSE TRUE FALSE FALSE FALSE FALSE +#> [85] TRUE TRUE FALSE TRUE TRUE FALSE FALSE FALSE FALSE FALSE FALSE FALSE #> [97] FALSE FALSE FALSE FALSE # filter on results from the third 60-day episode only, using base R df[which(get_episode(df$date, 60) == 3), ] -#> # A tibble: 1 × 46 -#> date patient age gender ward mo PEN OXA FLC AMX -#> <date> <chr> <dbl> <chr> <chr> <mo> <sir> <sir> <sir> <sir> -#> 1 2002-08-19 A49852 70 M Clinical B_ESCHR_COLI R NA NA NA +#> # A tibble: 3 × 46 +#> date patient age gender ward mo PEN OXA FLC AMX +#> <date> <chr> <dbl> <chr> <chr> <mo> <sir> <sir> <sir> <sir> +#> 1 2002-12-13 285137 78 F ICU B_ESCHR_COLI R NA NA NA +#> 2 2002-11-11 D80753 74 F Outpatie… B_STPHY_CONS R NA R R +#> 3 2003-01-08 783073 83 M Clinical B_STPHY_CONS R NA S NA #> # ℹ 36 more variables: AMC <sir>, AMP <sir>, TZP <sir>, CZO <sir>, FEP <sir>, #> # CXM <sir>, FOX <sir>, CTX <sir>, CAZ <sir>, CRO <sir>, GEN <sir>, #> # TOB <sir>, AMK <sir>, KAN <sir>, TMP <sir>, SXT <sir>, NIT <sir>, @@ -317,19 +319,19 @@ arrange(patient, condition, date) } #> # A tibble: 100 × 4 -#> # Groups: patient, condition [99] +#> # Groups: patient, condition [98] #> patient date condition new_episode #> <chr> <date> <chr> <lgl> -#> 1 006827 2009-07-24 B TRUE -#> 2 021648 2004-08-21 A TRUE -#> 3 023456 2011-04-25 C TRUE -#> 4 032343 2003-06-09 C TRUE -#> 5 074321 2015-09-20 C TRUE -#> 6 0D7D34 2011-03-19 B TRUE -#> 7 0E2483 2007-08-10 B TRUE -#> 8 164466 2009-10-07 B TRUE -#> 9 16DC39 2015-11-19 C TRUE -#> 10 189564 2009-12-22 C TRUE +#> 1 005088 2007-08-22 C TRUE +#> 2 008268 2007-02-20 C TRUE +#> 3 097186 2015-10-28 B TRUE +#> 4 0C0688 2014-09-05 A TRUE +#> 5 0DBB93 2009-05-08 C TRUE +#> 6 0E2483 2007-05-29 C TRUE +#> 7 0F9638 2014-09-22 A TRUE +#> 8 12CB58 2017-09-23 C TRUE +#> 9 1343BD 2016-04-02 C TRUE +#> 10 141061 2014-10-22 B TRUE #> # ℹ 90 more rows if (require("dplyr")) { @@ -343,19 +345,19 @@ arrange(patient, ward, date) } #> # A tibble: 100 × 5 -#> # Groups: ward, patient [97] +#> # Groups: ward, patient [95] #> ward date patient new_index new_logical #> <chr> <date> <chr> <int> <lgl> -#> 1 Clinical 2009-07-24 006827 1 TRUE -#> 2 Clinical 2004-08-21 021648 1 TRUE -#> 3 Clinical 2011-04-25 023456 1 TRUE -#> 4 Clinical 2003-06-09 032343 1 TRUE -#> 5 ICU 2015-09-20 074321 1 TRUE -#> 6 ICU 2011-03-19 0D7D34 1 TRUE -#> 7 ICU 2007-08-10 0E2483 1 TRUE -#> 8 Clinical 2009-10-07 164466 1 TRUE -#> 9 ICU 2015-11-19 16DC39 1 TRUE -#> 10 ICU 2009-12-22 189564 1 TRUE +#> 1 Clinical 2007-08-22 005088 1 TRUE +#> 2 ICU 2007-02-20 008268 1 TRUE +#> 3 Clinical 2015-10-28 097186 1 TRUE +#> 4 Clinical 2014-09-05 0C0688 1 TRUE +#> 5 Clinical 2009-05-08 0DBB93 1 TRUE +#> 6 Clinical 2007-05-29 0E2483 1 TRUE +#> 7 Clinical 2014-09-22 0F9638 1 TRUE +#> 8 ICU 2017-09-23 12CB58 1 TRUE +#> 9 Clinical 2016-04-02 1343BD 1 TRUE +#> 10 Clinical 2014-10-22 141061 1 TRUE #> # ℹ 90 more rows if (require("dplyr")) { @@ -371,9 +373,9 @@ #> # A tibble: 3 × 5 #> ward n_patients n_episodes_365 n_episodes_60 n_episodes_30 #> <chr> <int> <int> <int> <int> -#> 1 Clinical 60 13 37 45 -#> 2 ICU 31 12 22 27 -#> 3 Outpatient 6 3 5 5 +#> 1 Clinical 67 13 41 51 +#> 2 ICU 23 10 19 21 +#> 3 Outpatient 5 5 5 5 # grouping on patients and microorganisms leads to the same # results as first_isolate() when using 'episode-based': @@ -403,18 +405,18 @@ } #> # A tibble: 100 × 4 #> # Groups: patient, mo, ward [98] -#> patient mo ward flag_episode -#> <chr> <mo> <chr> <lgl> -#> 1 451000 B_ESCHR_COLI Clinical TRUE -#> 2 741413 B_ESCHR_COLI Clinical TRUE -#> 3 8BBC46 B_ENTRC_FACM Clinical TRUE -#> 4 F09078 B_ESCHR_COLI Clinical TRUE -#> 5 C56827 B_ESCHR_COLI Clinical TRUE -#> 6 D27410 B_BCTRD_FRGL Outpatient TRUE -#> 7 D38469 UNKNOWN ICU TRUE -#> 8 023456 B_PROTS_MRBL Clinical TRUE -#> 9 2FC253 B_ESCHR_COLI ICU TRUE -#> 10 EB1709 B_STRPT_PNMN ICU TRUE +#> patient mo ward flag_episode +#> <chr> <mo> <chr> <lgl> +#> 1 838694 B_ACNTB Clinical TRUE +#> 2 699321 B_STPHY_CONS Clinical TRUE +#> 3 C6F894 B_STPHY_EPDR Clinical TRUE +#> 4 D10538 B_ESCHR_COLI ICU TRUE +#> 5 164466 B_STPHY_CONS Clinical TRUE +#> 6 0C0688 B_ESCHR_COLI Clinical TRUE +#> 7 317826 B_ESCHR_COLI ICU TRUE +#> 8 195736 B_STPHY_AURS Clinical TRUE +#> 9 288260 B_STPHY_EPDR ICU TRUE +#> 10 141061 B_STPHY_HMNS Clinical TRUE #> # ℹ 90 more rows # } diff --git a/reference/ggplot_pca.html b/reference/ggplot_pca.html index c0bd455a..6c50516e 100644 --- a/reference/ggplot_pca.html +++ b/reference/ggplot_pca.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/ggplot_sir.html b/reference/ggplot_sir.html index 3797b430..3fa552e1 100644 --- a/reference/ggplot_sir.html +++ b/reference/ggplot_sir.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/guess_ab_col.html b/reference/guess_ab_col.html index 622c021e..3e64d59c 100644 --- a/reference/guess_ab_col.html +++ b/reference/guess_ab_col.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/index.html b/reference/index.html index b3cef810..c60f3261 100644 --- a/reference/index.html +++ b/reference/index.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 @@ -413,7 +413,7 @@ microorganisms.codes - Data Set with 4 909 Common Microorganism Codes + Data Set with 4 942 Common Microorganism Codes antibiotics antivirals diff --git a/reference/intrinsic_resistant.html b/reference/intrinsic_resistant.html index 4f7ecf01..3e50456e 100644 --- a/reference/intrinsic_resistant.html +++ b/reference/intrinsic_resistant.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/italicise_taxonomy.html b/reference/italicise_taxonomy.html index cb21c220..a206c274 100644 --- a/reference/italicise_taxonomy.html +++ b/reference/italicise_taxonomy.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/join.html b/reference/join.html index 05dbc34d..3394f872 100644 --- a/reference/join.html +++ b/reference/join.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/key_antimicrobials.html b/reference/key_antimicrobials.html index 5d7f7028..e4ac08d1 100644 --- a/reference/key_antimicrobials.html +++ b/reference/key_antimicrobials.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 diff --git a/reference/kurtosis.html b/reference/kurtosis.html index a4a83e71..90bd2f5b 100644 --- a/reference/kurtosis.html +++ b/reference/kurtosis.html @@ -10,7 +10,7 @@ AMR (for R) - 2.0.0.9023 + 2.0.0.9024 @@ -199,9 +199,9 @@ Examples kurtosis(rnorm(10000)) -#> [1] 3.010824 +#> [1] 2.980956 kurtosis(rnorm(10000), excess = TRUE) -#> [1] 0.1430003 +#> [1] -0.02318823
vignettes/datasets.Rmd
datasets.Rmd
clinical_breakpoints
A data set with 18 271 rows and 11 columns, containing the following +
A data set with 42 599 rows and 12 columns, containing the following column names:guideline, method, site, mo, rank_index, ab, ref_tbl, disk_dose, -breakpoint_S, breakpoint_R, and uti.
This data set is in R available as clinical_breakpoints, after you load the AMR package.
AMR
It was last updated on 20 April 2023 13:20:41 UTC. Find more info +
It was last updated on 22 June 2023 13:10:59 UTC. Find more info about the structure of this data set here.
Direct download links:
This data set contains interpretation rules for MIC values and disk -diffusion diameters. Included guidelines are CLSI (2013-2022) and EUCAST -(2013-2022).
dosage
A data set with 336 rows and 9 columns, containing the following +
A data set with 503 rows and 9 columns, containing the following column names:ab, name, type, dose, dose_times, administration, notes, original_txt, and eucast_version.
This data set is in R available as dosage, after you load the AMR package.
It was last updated on 14 November 2022 14:20:39 UTC. Find more info +
EUCAST breakpoints used in this package are based on the dosages in this data set.
Currently included dosages in the data set are meant for: ‘EUCAST Clinical -Breakpoint Tables’ v11.0 (2021) and ‘EUCAST Clinical -Breakpoint Tables’ v12.0 (2022).
The AMR package is a free and open-source R package with zero dependencies to simplify the analysis and prediction of Antimicrobial Resistance (AMR) and to work with microbial and antimicrobial data and properties, by using evidence-based methods. Our aim is to provide a standard for clean and reproducible AMR data analysis, that can therefore empower epidemiological analyses to continuously enable surveillance and treatment evaluation in any setting. Many different researchers from around the globe are continually helping us to make this a successful and durable project!
This work was published in the Journal of Statistical Software (Volume 104(3); DOI 10.18637/jss.v104.i03) and formed the basis of two PhD theses (DOI 10.33612/diss.177417131 and DOI 10.33612/diss.192486375).
After installing this package, R knows ~52,000 distinct microbial species (updated December 2022) and all ~600 antibiotic, antimycotic and antiviral drugs by name and code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC and SNOMED CT), and knows all about valid SIR and MIC values. The integral breakpoint guidelines from CLSI and EUCAST are included from the last 10 years. It supports and can read any data format, including WHONET data. This package works on Windows, macOS and Linux with all versions of R since R-3.0 (April 2013). It was designed to work in any setting, including those with very limited resources. It was created for both routine data analysis and academic research at the Faculty of Medical Sciences of the University of Groningen, in collaboration with non-profit organisations Certe Medical Diagnostics and Advice Foundation and University Medical Center Groningen.
After installing this package, R knows ~52,000 distinct microbial species (updated December 2022) and all ~600 antibiotic, antimycotic and antiviral drugs by name and code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC and SNOMED CT), and knows all about valid SIR and MIC values. The integral clinical breakpoint guidelines from CLSI and EUCAST are included, even with epidemiological cut-off (ECOFF) values. It supports and can read any data format, including WHONET data. This package works on Windows, macOS and Linux with all versions of R since R-3.0 (April 2013). It was designed to work in any setting, including those with very limited resources. It was created for both routine data analysis and academic research at the Faculty of Medical Sciences of the University of Groningen, in collaboration with non-profit organisations Certe Medical Diagnostics and Advice Foundation and University Medical Center Groningen.
This package was intended as a comprehensive toolbox for integrated AMR data analysis. This package can be used for:
Manually, using:
install.packages("remotes") # if you haven't already -remotes::install_github("msberends/AMR")
Automatically, using the rOpenSci R-universe platform, by adding our R-universe address to your list of repositories (‘repos’):
microorganisms
as.sir()
ecoff
as.sir(..., ecoff = TRUE)
mo_oxygen_tolerance()
mo_is_anaerobic()
.xpt
mo_rank()
NA
B_ANAER
B_ANAER-NEG
B_ANAER-POS
B_GRAMN
B_GRAMP
F_FUNGUS
F_YEAST
UNKNOWN
sir_interpretation_history()
as.mo()
icu_exclude
first_isolates()
keep_synonyms
minimum_matching_score
microorganisms.codes
AMR_custom_ab Allows to use custom antimicrobial drugs with this package. This is explained in add_custom_antimicrobials().
AMR_custom_ab
add_custom_antimicrobials()
AMR_custom_mo Allows to use custom microorganisms with this package. This is explained in add_custom_microorganisms().
AMR_custom_mo
add_custom_microorganisms()
AMR_eucastrules Used for setting the default types of rules for eucast_rules() function, must be one or more of: "breakpoints", "expert", "other", "custom", "all", and defaults to c("breakpoints", "expert").
AMR_eucastrules
"breakpoints"
"expert"
"other"
"custom"
"all"
c("breakpoints", "expert")
AMR_guideline Used for setting the default guideline for interpreting MIC values and disk diffusion diameters with as.sir(). Can be only the guideline name (e.g., "CLSI") or the name with a year (e.g. "CLSI 2019"). The default to the latest implemented EUCAST guideline, currently "EUCAST 2022". Supported guideline are currently EUCAST (2013-2022) and CLSI (2013-2022).
AMR_guideline
"CLSI"
"CLSI 2019"
"EUCAST 2022"
AMR_guideline Used for setting the default guideline for interpreting MIC values and disk diffusion diameters with as.sir(). Can be only the guideline name (e.g., "CLSI") or the name with a year (e.g. "CLSI 2019"). The default to the latest implemented EUCAST guideline, currently "EUCAST 2023". Supported guideline are currently EUCAST (2011-2023) and CLSI (2011-2023).
"EUCAST 2023"
AMR_ignore_pattern A regular expression to ignore (i.e., make NA) any match given in as.mo() and all mo_* functions.
AMR_ignore_pattern
mo_*
AMR_include_PKPD A logical to use in as.sir(), to indicate that PK/PD clinical breakpoints must be applied as a last resort - the default is TRUE.
AMR_include_PKPD
TRUE
AMR_ecoff A logical use in as.sir(), to indicate that ECOFF (Epidemiological Cut-Off) values must be used - the default is FALSE.
AMR_ecoff
FALSE
AMR_include_screening A logical to use in as.sir(), to indicate that clinical breakpoints for screening are allowed - the default is FALSE.
AMR_include_screening
AMR_keep_synonyms A logical to use in as.mo() and all mo_* functions, to indicate if old, previously valid taxonomic names must be preserved and not be corrected to currently accepted names. The default is FALSE.
AMR_keep_synonyms
AMR_cleaning_regex A regular expression (case-insensitive) to use in as.mo() and all mo_* functions, to clean the user input. The default is the outcome of mo_cleaning_regex(), which removes texts between brackets and texts such as "species" and "serovar".
AMR_cleaning_regex
mo_cleaning_regex()
Data set containing clinical breakpoints to interpret MIC and disk diffusion to SIR values, according to international guidelines. Currently implemented guidelines are EUCAST (2013-2022) and CLSI (2013-2022). Use as.sir() to transform MICs or disks measurements to SIR values.
Data set containing clinical breakpoints to interpret MIC and disk diffusion to SIR values, according to international guidelines. Currently implemented guidelines are EUCAST (2011-2023) and CLSI (2011-2023). Use as.sir() to transform MICs or disks measurements to SIR values.
A tibble with 18 271 observations and 11 variables:
guideline Name of the guideline
guideline
A tibble with 42 599 observations and 12 variables:
method Either "DISK" or "MIC"
method
site Body site, e.g. "Oral" or "Respiratory"
site
mo Microbial ID, see as.mo()
mo
disk_dose Dose of the used disk diffusion method
disk_dose
breakpoint_S Lowest MIC value or highest number of millimetres that leads to "S"
breakpoint_S
breakpoint_R Highest MIC value or lowest number of millimetres that leads to "R"
breakpoint_R
ecoff Epidemiological cut-off (ECOFF) value, used in antimicrobial susceptibility testing to differentiate between wild-type and non-wild-type strains of bacteria or fungi (use as.sir(..., ecoff = TRUE) to interpret raw data using ECOFF values)
uti A logical value (TRUE/FALSE) to indicate whether the rule applies to a urinary tract infection (UTI)
uti
Like all data sets in this package, this data set is publicly available for download in the following formats: R, MS Excel, Apache Feather, Apache Parquet, SPSS, SAS, and Stata. Please visit our website for the download links. The actual files are of course available on our GitHub repository.
Clinical breakpoints are validated through WHONET, a free desktop Windows application developed and supported by the WHO Collaborating Centre for Surveillance of Antimicrobial Resistance. More can be read on their website.
They allow for machine reading EUCAST and CLSI guidelines, which is almost impossible with the MS Excel and PDF files distributed by EUCAST and CLSI.
clinical_breakpoints -#> # A tibble: 18,271 × 11 -#> guideline method site mo rank_index ab ref_tbl disk_dose -#> <chr> <chr> <chr> <mo> <dbl> <ab> <chr> <chr> -#> 1 EUCAST 2022 MIC NA F_ASPRG_MGTS 2 AMB Aspergil… NA -#> 2 EUCAST 2022 MIC NA F_ASPRG_NIGR 2 AMB Aspergil… NA -#> 3 EUCAST 2022 MIC NA F_CANDD_ALBC 2 AMB Candida NA -#> 4 EUCAST 2022 MIC NA F_CANDD_DBLN 2 AMB Candida NA -#> 5 EUCAST 2022 MIC NA F_CANDD_GLBR 2 AMB Candida NA -#> 6 EUCAST 2022 MIC NA F_CANDD_KRUS 2 AMB Candida NA -#> 7 EUCAST 2022 MIC NA F_CANDD_PRPS 2 AMB Candida NA -#> 8 EUCAST 2022 MIC NA F_CANDD_TRPC 2 AMB Candida NA -#> 9 EUCAST 2022 MIC NA F_CRYPT_NFRM 2 AMB Candida NA -#> 10 EUCAST 2022 DISK NA B_[ORD]_ENTRBCTR 5 AMC Enteroba… 20ug/10ug -#> # ℹ 18,261 more rows -#> # ℹ 3 more variables: breakpoint_S <dbl>, breakpoint_R <dbl>, uti <lgl> +#> # A tibble: 42,599 × 12 +#> guideline method site mo rank_index ab ref_tbl disk_dose +#> <chr> <chr> <chr> <mo> <dbl> <ab> <chr> <chr> +#> 1 EUCAST 2023 MIC NA F_ASPRG_MGTS 2 AMB Aspergillus NA +#> 2 EUCAST 2023 MIC NA F_ASPRG_NIGR 2 AMB Aspergillus NA +#> 3 EUCAST 2023 MIC NA F_CANDD_ALBC 2 AMB Candida NA +#> 4 EUCAST 2023 MIC NA F_CANDD_DBLN 2 AMB Candida NA +#> 5 EUCAST 2023 MIC NA F_CANDD_GLBR 2 AMB Candida NA +#> 6 EUCAST 2023 MIC NA F_CANDD_KRUS 2 AMB Candida NA +#> 7 EUCAST 2023 MIC NA F_CANDD_PRPS 2 AMB Candida NA +#> 8 EUCAST 2023 MIC NA F_CANDD_TRPC 2 AMB Candida NA +#> 9 EUCAST 2023 MIC NA F_CRYPT_NFRM 2 AMB Candida NA +#> 10 EUCAST 2023 MIC NA B_ANAER-NEG 6 AMC Gram-negativ… NA +#> # ℹ 42,589 more rows +#> # ℹ 4 more variables: breakpoint_S <dbl>, breakpoint_R <dbl>, ecoff <dbl>, +#> # uti <lgl>
the version number to use for the EUCAST Clinical Breakpoints guideline. Can be either "12.0", "11.0", or "10.0".
the version number to use for the EUCAST Clinical Breakpoints guideline. Can be "13.0", "12.0", "11.0", or "10.0".
the version number to use for the EUCAST Expert Rules and Intrinsic Resistance guideline. Can be either "3.3", "3.2", or "3.1".
the version number to use for the EUCAST Expert Rules and Intrinsic Resistance guideline. Can be "3.3", "3.2", or "3.1".
the version number to use for the EUCAST Expected Resistant Phenotypes. Can be "1.2".
antibiotics
antivirals
kurtosis(rnorm(10000)) -#> [1] 3.010824 +#> [1] 2.980956 kurtosis(rnorm(10000), excess = TRUE) -#> [1] 0.1430003 +#> [1] -0.02318823