diff --git a/DESCRIPTION b/DESCRIPTION
index 65dca906..8fa764c7 100644
--- a/DESCRIPTION
+++ b/DESCRIPTION
@@ -1,6 +1,6 @@
 Package: AMR
-Version: 2.1.1.9049
-Date: 2024-06-14
+Version: 2.1.1.9050
+Date: 2024-06-15
 Title: Antimicrobial Resistance Data Analysis
 Description: Functions to simplify and standardise antimicrobial resistance (AMR)
   data analysis and to work with microbial and antimicrobial properties by
diff --git a/NAMESPACE b/NAMESPACE
index b168cc8e..e81a07bd 100644
--- a/NAMESPACE
+++ b/NAMESPACE
@@ -84,6 +84,7 @@ S3method(plot,mic)
 S3method(plot,resistance_predict)
 S3method(plot,sir)
 S3method(print,ab)
+S3method(print,ab_selector)
 S3method(print,av)
 S3method(print,bug_drug_combinations)
 S3method(print,custom_eucast_rules)
diff --git a/NEWS.md b/NEWS.md
index aaab189e..d8d8df8e 100644
--- a/NEWS.md
+++ b/NEWS.md
@@ -1,4 +1,4 @@
-# AMR 2.1.1.9049
+# AMR 2.1.1.9050
 
 *(this beta version will eventually become v3.0. We're happy to reach a new major milestone soon, which will be all about the new One Health support!)*
 
diff --git a/R/aa_helper_functions.R b/R/aa_helper_functions.R
index 91c5f59c..25938aa1 100644
--- a/R/aa_helper_functions.R
+++ b/R/aa_helper_functions.R
@@ -524,6 +524,9 @@ word_wrap <- function(...,
     # otherwise, give a 'click to run' popup
     parts[cmds & parts %unlike% "[.]"] <- font_url(url = paste0("ide:run:AMR::", parts[cmds & parts %unlike% "[.]"]),
                                                    txt = parts[cmds & parts %unlike% "[.]"])
+    # text starting with `?` must also lead to the help page
+    parts[parts %like% "^[?]"] <- font_url(url = paste0("ide:help:AMR::", gsub("()", "", gsub("^[?]", "", parts[parts %like% "^[?]"]), fixed = TRUE)),
+                                           txt = parts[parts %like% "^[?]"])
     msg <- paste0(parts, collapse = "`")
   }
   msg <- gsub("`(.+?)`", font_grey_bg("\\1"), msg)
diff --git a/R/ab_selectors.R b/R/ab_selectors.R
index 4a20fee6..56c6a7f8 100755
--- a/R/ab_selectors.R
+++ b/R/ab_selectors.R
@@ -57,59 +57,31 @@
 #' example_isolates
 #'
 #'
-#' # Examples sections below are split into 'base R', 'dplyr', and 'data.table':
-#'
-#'
-#' # base R ------------------------------------------------------------------
-#'
-#' # select columns 'IPM' (imipenem) and 'MEM' (meropenem)
-#' example_isolates[, carbapenems()]
-#'
-#' # select columns 'mo', 'AMK', 'GEN', 'KAN' and 'TOB'
-#' example_isolates[, c("mo", aminoglycosides())]
-#'
-#' # select only antibiotic columns with DDDs for oral treatment
-#' example_isolates[, administrable_per_os()]
-#'
-#' # filter using any() or all()
-#' example_isolates[any(carbapenems() == "R"), ]
-#' subset(example_isolates, any(carbapenems() == "R"))
-#'
-#' # filter on any or all results in the carbapenem columns (i.e., IPM, MEM):
-#' example_isolates[any(carbapenems()), ]
-#' example_isolates[all(carbapenems()), ]
-#'
-#' # filter with multiple antibiotic selectors using c()
-#' example_isolates[all(c(carbapenems(), aminoglycosides()) == "R"), ]
-#'
-#' # filter + select in one go: get penicillins in carbapenem-resistant strains
-#' example_isolates[any(carbapenems() == "R"), penicillins()]
-#'
-#' # You can combine selectors with '&' to be more specific. For example,
-#' # penicillins() would select benzylpenicillin ('peni G') and
-#' # administrable_per_os() would select erythromycin. Yet, when combined these
-#' # drugs are both omitted since benzylpenicillin is not administrable per os
-#' # and erythromycin is not a penicillin:
-#' example_isolates[, penicillins() & administrable_per_os()]
-#'
-#' # ab_selector() applies a filter in the `antibiotics` data set and is thus
-#' # very flexible. For instance, to select antibiotic columns with an oral DDD
-#' # of at least 1 gram:
-#' example_isolates[, ab_selector(oral_ddd > 1 & oral_units == "g")]
-#'
+#' # Examples sections below are split into 'dplyr', 'base R', and 'data.table':
+#' 
 #' \donttest{
 #' # dplyr -------------------------------------------------------------------
+#' 
+#' if (require("dplyr")) {
+#'.  example_isolates %>% select(carbapenems())
+#' }
 #'
 #' if (require("dplyr")) {
-#'   tibble(kefzol = random_sir(5)) %>%
-#'     select(cephalosporins())
+#'   # select columns 'mo', 'AMK', 'GEN', 'KAN' and 'TOB'
+#'   example_isolates %>% select(mo, aminoglycosides())
+#' }
+#'
+#' if (require("dplyr")) {
+#'   # select only antibiotic columns with DDDs for oral treatment
+#'.  example_isolates %>% select(administrable_per_os())
 #' }
 #'
 #' if (require("dplyr")) {
 #'   # get AMR for all aminoglycosides e.g., per ward:
 #'   example_isolates %>%
 #'     group_by(ward) %>%
-#'     summarise(across(aminoglycosides(), resistance))
+#'     summarise(across(aminoglycosides(),
+#'                      resistance))
 #' }
 #' if (require("dplyr")) {
 #'   # You can combine selectors with '&' to be more specific:
@@ -121,7 +93,8 @@
 #'   example_isolates %>%
 #'     filter(mo_genus() %in% c("Escherichia", "Klebsiella")) %>%
 #'     group_by(ward) %>%
-#'     summarise(across(not_intrinsic_resistant(), resistance))
+#'     summarise_at(not_intrinsic_resistant(),
+#'                  resistance)
 #' }
 #' if (require("dplyr")) {
 #'   # get susceptibility for antibiotics whose name contains "trim":
@@ -187,6 +160,44 @@
 #' }
 #'
 #'
+#' # base R ------------------------------------------------------------------
+#'
+#' # select columns 'IPM' (imipenem) and 'MEM' (meropenem)
+#' example_isolates[, carbapenems()]
+#'
+#' # select columns 'mo', 'AMK', 'GEN', 'KAN' and 'TOB'
+#' example_isolates[, c("mo", aminoglycosides())]
+#'
+#' # select only antibiotic columns with DDDs for oral treatment
+#' example_isolates[, administrable_per_os()]
+#'
+#' # filter using any() or all()
+#' example_isolates[any(carbapenems() == "R"), ]
+#' subset(example_isolates, any(carbapenems() == "R"))
+#'
+#' # filter on any or all results in the carbapenem columns (i.e., IPM, MEM):
+#' example_isolates[any(carbapenems()), ]
+#' example_isolates[all(carbapenems()), ]
+#'
+#' # filter with multiple antibiotic selectors using c()
+#' example_isolates[all(c(carbapenems(), aminoglycosides()) == "R"), ]
+#'
+#' # filter + select in one go: get penicillins in carbapenem-resistant strains
+#' example_isolates[any(carbapenems() == "R"), penicillins()]
+#'
+#' # You can combine selectors with '&' to be more specific. For example,
+#' # penicillins() would select benzylpenicillin ('peni G') and
+#' # administrable_per_os() would select erythromycin. Yet, when combined these
+#' # drugs are both omitted since benzylpenicillin is not administrable per os
+#' # and erythromycin is not a penicillin:
+#' example_isolates[, penicillins() & administrable_per_os()]
+#'
+#' # ab_selector() applies a filter in the `antibiotics` data set and is thus
+#' # very flexible. For instance, to select antibiotic columns with an oral DDD
+#' # of at least 1 gram:
+#' example_isolates[, ab_selector(oral_ddd > 1 & oral_units == "g")]
+#'
+#'
 #' # data.table --------------------------------------------------------------
 #'
 #' # data.table is supported as well, just use it in the same way as with
@@ -679,6 +690,16 @@ ab_select_exec <- function(function_name,
   )
 }
 
+#' @method print ab_selector
+#' @export
+#' @noRd
+print.ab_selector <- function(x, ...) {
+  warning_("It should never be needed to print an antibiotic selector class. Are you using data.table? Then add the argument `with = FALSE`, see our examples at `?ab_selector`.",
+           immediate = TRUE)
+  cat("Class 'ab_selector'\n")
+  print(as.character(x), quote = FALSE)
+}
+
 #' @method c ab_selector
 #' @export
 #' @noRd
diff --git a/R/eucast_rules.R b/R/eucast_rules.R
index c74c05d8..ce330387 100755
--- a/R/eucast_rules.R
+++ b/R/eucast_rules.R
@@ -462,7 +462,7 @@ eucast_rules <- function(x,
           font_red(paste0(
             "v", utils::packageDescription("AMR")$Version, ", ",
             format(as.Date(utils::packageDescription("AMR")$Date), format = "%Y")
-          )), "), see ?eucast_rules\n"
+          )), "), see `?eucast_rules`\n"
         ))
       ))
     }
diff --git a/R/key_antimicrobials.R b/R/key_antimicrobials.R
index fbae1a3f..2916c13c 100755
--- a/R/key_antimicrobials.R
+++ b/R/key_antimicrobials.R
@@ -188,7 +188,7 @@ key_antimicrobials <- function(x = NULL,
           "No columns available ",
           paste0("Only using ", values_new_length, " out of ", values_old_length, " defined columns ")
         ),
-        "as key antimicrobials for ", name, "s. See ?key_antimicrobials."
+        "as key antimicrobials for ", name, "s. See `?key_antimicrobials`."
       )
     }
 
diff --git a/R/pca.R b/R/pca.R
index 7c13a348..802a058c 100755
--- a/R/pca.R
+++ b/R/pca.R
@@ -113,7 +113,7 @@ pca <- function(x,
 
     x <- as.data.frame(new_list, stringsAsFactors = FALSE)
     if (any(vapply(FUN.VALUE = logical(1), x, function(y) !is.numeric(y)))) {
-      warning_("in `pca()`: be sure to first calculate the resistance (or susceptibility) of variables with antimicrobial test results, since PCA works with numeric variables only. See Examples in ?pca.", call = FALSE)
+      warning_("in `pca()`: be sure to first calculate the resistance (or susceptibility) of variables with antimicrobial test results, since PCA works with numeric variables only. See Examples in `?pca`.", call = FALSE)
     }
 
     # set column names
diff --git a/R/resistance_predict.R b/R/resistance_predict.R
index 2c50a36c..c4221e68 100755
--- a/R/resistance_predict.R
+++ b/R/resistance_predict.R
@@ -231,7 +231,7 @@ resistance_predict <- function(x,
     prediction <- predictmodel$fit
     se <- predictmodel$se.fit
   } else {
-    stop("no valid model selected. See ?resistance_predict.")
+    stop("no valid model selected. See `?resistance_predict`.")
   }
 
   # prepare the output dataframe
diff --git a/R/sir.R b/R/sir.R
index c797635e..affb5ce0 100755
--- a/R/sir.R
+++ b/R/sir.R
@@ -158,6 +158,51 @@
 #'
 #' # For INTERPRETING disk diffusion and MIC values -----------------------
 #'
+#' \donttest{
+#' ## Using dplyr -------------------------------------------------
+#' if (require("dplyr")) {
+#'   # approaches that all work without additional arguments:
+#'   df %>% mutate_if(is.mic, as.sir)
+#'   df %>% mutate_if(function(x) is.mic(x) | is.disk(x), as.sir)
+#'   df %>% mutate(across(where(is.mic), as.sir))
+#'   df %>% mutate_at(vars(AMP:TOB), as.sir)
+#'   df %>% mutate(across(AMP:TOB, as.sir))
+#'   
+#'   # approaches that all work with additional arguments:
+#'   df %>% mutate_if(is.mic, as.sir, mo = "column1", guideline = "CLSI")
+#'   df %>% mutate(across(where(is.mic),
+#'                        function(x) as.sir(x, mo = "column1", guideline = "CLSI")))
+#'   df %>% mutate_at(vars(AMP:TOB), as.sir, mo = "column1", guideline = "CLSI")
+#'   df %>% mutate(across(AMP:TOB,
+#'                        function(x) as.sir(x, mo = "column1", guideline = "CLSI")))
+#'                        
+#'   # for veterinary breakpoints, add 'host':
+#'   df %>% mutate_if(is.mic, as.sir, guideline = "CLSI", host = "species_column")
+#'   df %>% mutate_if(is.mic, as.sir, guideline = "CLSI", host = "horse")
+#'   df %>% mutate(across(where(is.mic),
+#'                        function(x) as.sir(x, guideline = "CLSI", host = "species_column")))
+#'   df %>% mutate_at(vars(AMP:TOB), as.sir, guideline = "CLSI", host = "species_column")
+#'   df %>% mutate(across(AMP:TOB,
+#'                        function(x) as.sir(x, mo = "column1", guideline = "CLSI")))
+#'   
+#'   # to include information about urinary tract infections (UTI)
+#'   data.frame(mo = "E. coli",
+#'              nitrofuratoin = c("<= 2", 32),
+#'              from_the_bladder = c(TRUE, FALSE)) %>%
+#'     as.sir(uti = "from_the_bladder")
+#'
+#'   data.frame(mo = "E. coli",
+#'              nitrofuratoin = c("<= 2", 32),
+#'              specimen = c("urine", "blood")) %>%
+#'     as.sir() # automatically determines urine isolates
+#'
+#'   df %>%
+#'     mutate_at(vars(AMP:TOB), as.sir, mo = "E. coli", uti = TRUE)
+#' }
+#'
+#'
+#' ## Using base R ------------------------------------------------
+#'
 #' # a whole data set, even with combined MIC values and disk zones
 #' df <- data.frame(
 #'   microorganism = "Escherichia coli",
@@ -187,36 +232,6 @@
 #'   guideline = "EUCAST"
 #' )
 #'
-#' \donttest{
-#' # the dplyr way
-#' if (require("dplyr")) {
-#'   df %>% mutate_if(is.mic, as.sir)
-#'   df %>% mutate_if(function(x) is.mic(x) | is.disk(x), as.sir)
-#'   df %>% mutate(across(where(is.mic), as.sir))
-#'   df %>% mutate_at(vars(AMP:TOB), as.sir)
-#'   df %>% mutate(across(AMP:TOB, as.sir))
-#'
-#'   df %>%
-#'     mutate_at(vars(AMP:TOB), as.sir, mo = "microorganism")
-#'
-#'   # to include information about urinary tract infections (UTI)
-#'   data.frame(
-#'     mo = "E. coli",
-#'     NIT = c("<= 2", 32),
-#'     from_the_bladder = c(TRUE, FALSE)
-#'   ) %>%
-#'     as.sir(uti = "from_the_bladder")
-#'
-#'   data.frame(
-#'     mo = "E. coli",
-#'     NIT = c("<= 2", 32),
-#'     specimen = c("urine", "blood")
-#'   ) %>%
-#'     as.sir() # automatically determines urine isolates
-#'
-#'   df %>%
-#'     mutate_at(vars(AMP:TOB), as.sir, mo = "E. coli", uti = TRUE)
-#' }
 #'
 #' # For CLEANING existing SIR values ------------------------------------
 #'
@@ -1121,6 +1136,7 @@ as_sir_method <- function(method_short,
       suppressMessages(suppressWarnings(ab_name(ab_current, language = NULL, tolower = TRUE))),
       " (", ab_current, ")"
     )
+    notes <- character(0)
    
     # gather all available breakpoints for current MO
     breakpoints_current <- breakpoints %pm>%
@@ -1165,7 +1181,8 @@ as_sir_method <- function(method_short,
           subset(host_match == TRUE)
       } else {
         # no breakpoint found for this host, so sort on mostly available guidelines
-        msgs <- c(msgs, paste0("No breakpoints available for ", font_bold(host_current), " for ", ab_formatted, " in ", mo_formatted, " - using ", font_bold(breakpoints_current$host[1]), " instead."))
+        notes <- c(notes, paste0("No breakpoints available for ", font_bold(host_current), " for ", ab_formatted, " in ", mo_formatted, " - using ", font_bold(breakpoints_current$host[1]), " instead."))
+        # msgs <- c(msgs, paste0("No breakpoints available for ", font_bold(host_current), " for ", ab_formatted, " in ", mo_formatted, " - using ", font_bold(breakpoints_current$host[1]), " instead."))
       }
     }
  
@@ -1243,14 +1260,15 @@ as_sir_method <- function(method_short,
           mo_user = rep(mo.bak[match(mo_current, df$mo)][1], length(rows)),
           ab = rep(ab_current, length(rows)),
           mo = rep(breakpoints_current[, "mo", drop = TRUE], length(rows)),
+          method = rep(method_coerced, length(rows)),
           input = as.double(values),
           outcome = as.sir(new_sir),
-          method = rep(method_coerced, length(rows)),
-          breakpoint_S_R = rep(paste0(breakpoints_current[, "breakpoint_S", drop = TRUE], "-", breakpoints_current[, "breakpoint_R", drop = TRUE]), length(rows)),
-          guideline = rep(guideline_coerced, length(rows)),
           host = rep(breakpoints_current[, "host", drop = TRUE], length(rows)),
+          notes = rep(paste0(notes, collapse = " "), length(rows)),
+          guideline = rep(guideline_coerced, length(rows)),
           ref_table = rep(breakpoints_current[, "ref_tbl", drop = TRUE], length(rows)),
           uti = rep(breakpoints_current[, "uti", drop = TRUE], length(rows)),
+          breakpoint_S_R = rep(paste0(breakpoints_current[, "breakpoint_S", drop = TRUE], "-", breakpoints_current[, "breakpoint_R", drop = TRUE]), length(rows)),
           stringsAsFactors = FALSE
         )
       )
@@ -1268,6 +1286,8 @@ as_sir_method <- function(method_short,
   }
   if (isTRUE(rise_warning)) {
     message(font_rose_bg(" WARNING "))
+  } else if (length(notes) > 0) {
+    message(font_yellow_bg(" NOTES "))
   } else if (length(msgs) == 0) {
     message(font_green_bg(" OK "))
   } else {
diff --git a/R/vctrs.R b/R/vctrs.R
index db8855cd..36483276 100755
--- a/R/vctrs.R
+++ b/R/vctrs.R
@@ -109,10 +109,13 @@ vec_ptype_abbr.disk <- function(x, ...) {
   "dsk"
 }
 vec_ptype2.disk.default <- function (x, y, ..., x_arg = "", y_arg = "") {
-  x
+  NA_disk_[0]
 }
 vec_ptype2.disk.disk <- function(x, y, ...) {
-  x
+  NA_disk_[0]
+}
+vec_cast.disk.disk <- function(x, to, ...) {
+  as.disk(x)
 }
 vec_cast.integer.disk <- function(x, to, ...) {
   unclass(x)
@@ -136,11 +139,11 @@ vec_cast.disk.character <- function(x, to, ...) {
 # S3: mic ----
 vec_ptype2.mic.default <- function (x, y, ..., x_arg = "", y_arg = "") {
   # this will make sure that currently implemented MIC levels are returned
-  as.mic(x)
+  NA_mic_[0]
 }
 vec_ptype2.mic.mic <- function(x, y, ...) {
   # this will make sure that currently implemented MIC levels are returned
-  as.mic(x)
+  NA_mic_[0]
 }
 vec_cast.mic.mic <- function(x, to, ...) {
   # this will make sure that currently implemented MIC levels are returned
@@ -187,6 +190,10 @@ vec_ptype2.sir.sir <- function(x, y, ...) {
 vec_ptype2.character.sir <- function(x, y, ...) {
   NA_sir_[0]
 }
+vec_cast.sir.sir <- function(x, to, ...) {
+  # this makes sure that old SIR objects (with S/I/R) are converted to the current structure (S/SDD/I/R/NI)
+  as.sir(x)
+}
 vec_cast.character.sir <- function(x, to, ...) {
   as.character(x)
 }
diff --git a/R/zzz.R b/R/zzz.R
index 8af3068b..39cfcf78 100755
--- a/R/zzz.R
+++ b/R/zzz.R
@@ -62,13 +62,15 @@ AMR_env$sir_interpretation_history <- data.frame(
   mo_user = character(0),
   ab = set_clean_class(character(0), c("ab", "character")),
   mo = set_clean_class(character(0), c("mo", "character")),
+  method = character(0),
   input = double(0),
   outcome = NA_sir_[0],
-  method = character(0),
-  breakpoint_S_R = character(0),
-  guideline = character(0),
   host = character(0),
+  notes = character(0),
+  guideline = character(0),
   ref_table = character(0),
+  uti = logical(0),
+  breakpoint_S_R = character(0),
   stringsAsFactors = FALSE
 )
 
@@ -95,6 +97,7 @@ AMR_env$sup_1_icon <- import_fn("symbol", "cli", error_on_fail = FALSE)$sup_1 %o
   s3_register("pillar::pillar_shaft", "sir")
   s3_register("pillar::pillar_shaft", "mic")
   s3_register("pillar::pillar_shaft", "disk")
+  # no type_sum of disk, that's now in vctrs::vec_ptype_full
   s3_register("pillar::type_sum", "ab")
   s3_register("pillar::type_sum", "av")
   s3_register("pillar::type_sum", "mo")
@@ -153,6 +156,7 @@ AMR_env$sup_1_icon <- import_fn("symbol", "cli", error_on_fail = FALSE)$sup_1 %o
   s3_register("vctrs::vec_ptype_abbr", "disk")
   s3_register("vctrs::vec_ptype2", "disk.default")
   s3_register("vctrs::vec_ptype2", "disk.disk")
+  s3_register("vctrs::vec_cast", "disk.disk")
   s3_register("vctrs::vec_cast", "integer.disk")
   s3_register("vctrs::vec_cast", "disk.integer")
   s3_register("vctrs::vec_cast", "double.disk")
@@ -179,6 +183,7 @@ AMR_env$sup_1_icon <- import_fn("symbol", "cli", error_on_fail = FALSE)$sup_1 %o
   s3_register("vctrs::vec_ptype2", "character.sir")
   s3_register("vctrs::vec_cast", "character.sir")
   s3_register("vctrs::vec_cast", "sir.character")
+  s3_register("vctrs::vec_cast", "sir.sir")
 
   # if mo source exists, fire it up (see mo_source())
   if (tryCatch(file.exists(getOption("AMR_mo_source", "~/mo_source.rds")), error = function(e) FALSE)) {
diff --git a/data/example_isolates.rda b/data/example_isolates.rda
index 3a5d7af1..bb130884 100644
Binary files a/data/example_isolates.rda and b/data/example_isolates.rda differ
diff --git a/man/antibiotic_class_selectors.Rd b/man/antibiotic_class_selectors.Rd
index cb69f8b5..93ba5fa3 100644
--- a/man/antibiotic_class_selectors.Rd
+++ b/man/antibiotic_class_selectors.Rd
@@ -185,59 +185,31 @@ All data sets in this \code{AMR} package (about microorganisms, antibiotics, SIR
 example_isolates
 
 
-# Examples sections below are split into 'base R', 'dplyr', and 'data.table':
-
-
-# base R ------------------------------------------------------------------
-
-# select columns 'IPM' (imipenem) and 'MEM' (meropenem)
-example_isolates[, carbapenems()]
-
-# select columns 'mo', 'AMK', 'GEN', 'KAN' and 'TOB'
-example_isolates[, c("mo", aminoglycosides())]
-
-# select only antibiotic columns with DDDs for oral treatment
-example_isolates[, administrable_per_os()]
-
-# filter using any() or all()
-example_isolates[any(carbapenems() == "R"), ]
-subset(example_isolates, any(carbapenems() == "R"))
-
-# filter on any or all results in the carbapenem columns (i.e., IPM, MEM):
-example_isolates[any(carbapenems()), ]
-example_isolates[all(carbapenems()), ]
-
-# filter with multiple antibiotic selectors using c()
-example_isolates[all(c(carbapenems(), aminoglycosides()) == "R"), ]
-
-# filter + select in one go: get penicillins in carbapenem-resistant strains
-example_isolates[any(carbapenems() == "R"), penicillins()]
-
-# You can combine selectors with '&' to be more specific. For example,
-# penicillins() would select benzylpenicillin ('peni G') and
-# administrable_per_os() would select erythromycin. Yet, when combined these
-# drugs are both omitted since benzylpenicillin is not administrable per os
-# and erythromycin is not a penicillin:
-example_isolates[, penicillins() & administrable_per_os()]
-
-# ab_selector() applies a filter in the `antibiotics` data set and is thus
-# very flexible. For instance, to select antibiotic columns with an oral DDD
-# of at least 1 gram:
-example_isolates[, ab_selector(oral_ddd > 1 & oral_units == "g")]
+# Examples sections below are split into 'dplyr', 'base R', and 'data.table':
 
 \donttest{
 # dplyr -------------------------------------------------------------------
 
 if (require("dplyr")) {
-  tibble(kefzol = random_sir(5)) \%>\%
-    select(cephalosporins())
+.  example_isolates \%>\% select(carbapenems())
+}
+
+if (require("dplyr")) {
+  # select columns 'mo', 'AMK', 'GEN', 'KAN' and 'TOB'
+  example_isolates \%>\% select(mo, aminoglycosides())
+}
+
+if (require("dplyr")) {
+  # select only antibiotic columns with DDDs for oral treatment
+.  example_isolates \%>\% select(administrable_per_os())
 }
 
 if (require("dplyr")) {
   # get AMR for all aminoglycosides e.g., per ward:
   example_isolates \%>\%
     group_by(ward) \%>\%
-    summarise(across(aminoglycosides(), resistance))
+    summarise(across(aminoglycosides(),
+                     resistance))
 }
 if (require("dplyr")) {
   # You can combine selectors with '&' to be more specific:
@@ -249,7 +221,8 @@ if (require("dplyr")) {
   example_isolates \%>\%
     filter(mo_genus() \%in\% c("Escherichia", "Klebsiella")) \%>\%
     group_by(ward) \%>\%
-    summarise(across(not_intrinsic_resistant(), resistance))
+    summarise_at(not_intrinsic_resistant(),
+                 resistance)
 }
 if (require("dplyr")) {
   # get susceptibility for antibiotics whose name contains "trim":
@@ -315,6 +288,44 @@ if (require("dplyr")) {
 }
 
 
+# base R ------------------------------------------------------------------
+
+# select columns 'IPM' (imipenem) and 'MEM' (meropenem)
+example_isolates[, carbapenems()]
+
+# select columns 'mo', 'AMK', 'GEN', 'KAN' and 'TOB'
+example_isolates[, c("mo", aminoglycosides())]
+
+# select only antibiotic columns with DDDs for oral treatment
+example_isolates[, administrable_per_os()]
+
+# filter using any() or all()
+example_isolates[any(carbapenems() == "R"), ]
+subset(example_isolates, any(carbapenems() == "R"))
+
+# filter on any or all results in the carbapenem columns (i.e., IPM, MEM):
+example_isolates[any(carbapenems()), ]
+example_isolates[all(carbapenems()), ]
+
+# filter with multiple antibiotic selectors using c()
+example_isolates[all(c(carbapenems(), aminoglycosides()) == "R"), ]
+
+# filter + select in one go: get penicillins in carbapenem-resistant strains
+example_isolates[any(carbapenems() == "R"), penicillins()]
+
+# You can combine selectors with '&' to be more specific. For example,
+# penicillins() would select benzylpenicillin ('peni G') and
+# administrable_per_os() would select erythromycin. Yet, when combined these
+# drugs are both omitted since benzylpenicillin is not administrable per os
+# and erythromycin is not a penicillin:
+example_isolates[, penicillins() & administrable_per_os()]
+
+# ab_selector() applies a filter in the `antibiotics` data set and is thus
+# very flexible. For instance, to select antibiotic columns with an oral DDD
+# of at least 1 gram:
+example_isolates[, ab_selector(oral_ddd > 1 & oral_units == "g")]
+
+
 # data.table --------------------------------------------------------------
 
 # data.table is supported as well, just use it in the same way as with
diff --git a/man/as.sir.Rd b/man/as.sir.Rd
index 6384a13a..2ea89c64 100644
--- a/man/as.sir.Rd
+++ b/man/as.sir.Rd
@@ -251,6 +251,51 @@ summary(example_isolates) # see all SIR results at a glance
 
 # For INTERPRETING disk diffusion and MIC values -----------------------
 
+\donttest{
+## Using dplyr -------------------------------------------------
+if (require("dplyr")) {
+  # approaches that all work without additional arguments:
+  df \%>\% mutate_if(is.mic, as.sir)
+  df \%>\% mutate_if(function(x) is.mic(x) | is.disk(x), as.sir)
+  df \%>\% mutate(across(where(is.mic), as.sir))
+  df \%>\% mutate_at(vars(AMP:TOB), as.sir)
+  df \%>\% mutate(across(AMP:TOB, as.sir))
+  
+  # approaches that all work with additional arguments:
+  df \%>\% mutate_if(is.mic, as.sir, mo = "column1", guideline = "CLSI")
+  df \%>\% mutate(across(where(is.mic),
+                       function(x) as.sir(x, mo = "column1", guideline = "CLSI")))
+  df \%>\% mutate_at(vars(AMP:TOB), as.sir, mo = "column1", guideline = "CLSI")
+  df \%>\% mutate(across(AMP:TOB,
+                       function(x) as.sir(x, mo = "column1", guideline = "CLSI")))
+                       
+  # for veterinary breakpoints, add 'host':
+  df \%>\% mutate_if(is.mic, as.sir, guideline = "CLSI", host = "species_column")
+  df \%>\% mutate_if(is.mic, as.sir, guideline = "CLSI", host = "horse")
+  df \%>\% mutate(across(where(is.mic),
+                       function(x) as.sir(x, guideline = "CLSI", host = "species_column")))
+  df \%>\% mutate_at(vars(AMP:TOB), as.sir, guideline = "CLSI", host = "species_column")
+  df \%>\% mutate(across(AMP:TOB,
+                       function(x) as.sir(x, mo = "column1", guideline = "CLSI")))
+  
+  # to include information about urinary tract infections (UTI)
+  data.frame(mo = "E. coli",
+             nitrofuratoin = c("<= 2", 32),
+             from_the_bladder = c(TRUE, FALSE)) \%>\%
+    as.sir(uti = "from_the_bladder")
+
+  data.frame(mo = "E. coli",
+             nitrofuratoin = c("<= 2", 32),
+             specimen = c("urine", "blood")) \%>\%
+    as.sir() # automatically determines urine isolates
+
+  df \%>\%
+    mutate_at(vars(AMP:TOB), as.sir, mo = "E. coli", uti = TRUE)
+}
+
+
+## Using base R ------------------------------------------------
+
 # a whole data set, even with combined MIC values and disk zones
 df <- data.frame(
   microorganism = "Escherichia coli",
@@ -280,36 +325,6 @@ as.sir(
   guideline = "EUCAST"
 )
 
-\donttest{
-# the dplyr way
-if (require("dplyr")) {
-  df \%>\% mutate_if(is.mic, as.sir)
-  df \%>\% mutate_if(function(x) is.mic(x) | is.disk(x), as.sir)
-  df \%>\% mutate(across(where(is.mic), as.sir))
-  df \%>\% mutate_at(vars(AMP:TOB), as.sir)
-  df \%>\% mutate(across(AMP:TOB, as.sir))
-
-  df \%>\%
-    mutate_at(vars(AMP:TOB), as.sir, mo = "microorganism")
-
-  # to include information about urinary tract infections (UTI)
-  data.frame(
-    mo = "E. coli",
-    NIT = c("<= 2", 32),
-    from_the_bladder = c(TRUE, FALSE)
-  ) \%>\%
-    as.sir(uti = "from_the_bladder")
-
-  data.frame(
-    mo = "E. coli",
-    NIT = c("<= 2", 32),
-    specimen = c("urine", "blood")
-  ) \%>\%
-    as.sir() # automatically determines urine isolates
-
-  df \%>\%
-    mutate_at(vars(AMP:TOB), as.sir, mo = "E. coli", uti = TRUE)
-}
 
 # For CLEANING existing SIR values ------------------------------------