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+ + + + +
+
+

How to conduct AMR data analysis

+

Dr. Matthijs Berends

+ +

21 August 2022

+ + Source: vignettes/AMR.Rmd +
AMR.Rmd
+
+ + + +

Note: values on this page will change with every website update since they are based on randomly created values and the page was written in R Markdown. However, the methodology remains unchanged. This page was generated on 21 August 2022.

+
+

Introduction +

+

Conducting AMR data analysis unfortunately requires in-depth knowledge from different scientific fields, which makes it hard to do right. At least, it requires:

+
    +
  • Good questions (always start with those!)
    • +
  • A thorough understanding of (clinical) epidemiology, to understand the clinical and epidemiological relevance and possible bias of results
    • +
  • A thorough understanding of (clinical) microbiology/infectious diseases, to understand which microorganisms are causal to which infections and the implications of pharmaceutical treatment, as well as understanding intrinsic and acquired microbial resistance
    • +
  • Experience with data analysis with microbiological tests and their results, to understand the determination and limitations of MIC values and their interpretations to RSI values
    • +
  • Availability of the biological taxonomy of microorganisms and probably normalisation factors for pharmaceuticals, such as defined daily doses (DDD)
    • +
  • Available (inter-)national guidelines, and profound methods to apply them
    • +
+

Of course, we cannot instantly provide you with knowledge and experience. But with this AMR package, we aimed at providing (1) tools to simplify antimicrobial resistance data cleaning, transformation and analysis, (2) methods to easily incorporate international guidelines and (3) scientifically reliable reference data, including the requirements mentioned above.

+

The AMR package enables standardised and reproducible AMR data analysis, with the application of evidence-based rules, determination of first isolates, translation of various codes for microorganisms and antimicrobial agents, determination of (multi-drug) resistant microorganisms, and calculation of antimicrobial resistance, prevalence and future trends.

+
+
+

Preparation +

+

For this tutorial, we will create fake demonstration data to work with.

+

You can skip to Cleaning the data if you already have your own data ready. If you start your analysis, try to make the structure of your data generally look like this:

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
datepatient_idmoAMXCIP
2022-08-21abcdEscherichia coliSS
2022-08-21abcdEscherichia coliSR
2022-08-21efghEscherichia coliRS
+
+

Needed R packages +

+

As with many uses in R, we need some additional packages for AMR data analysis. Our package works closely together with the tidyverse packages dplyr and ggplot2 by RStudio. The tidyverse tremendously improves the way we conduct data science - it allows for a very natural way of writing syntaxes and creating beautiful plots in R.

+

We will also use the cleaner package, that can be used for cleaning data and creating frequency tables.

+
+library(dplyr)
+library(ggplot2)
+library(AMR)
+library(cleaner)
+
+# (if not yet installed, install with:)
+# install.packages(c("dplyr", "ggplot2", "AMR", "cleaner"))
+
+
+
+

Creation of data +

+

We will create some fake example data to use for analysis. For AMR data analysis, we need at least: a patient ID, name or code of a microorganism, a date and antimicrobial results (an antibiogram). It could also include a specimen type (e.g. to filter on blood or urine), the ward type (e.g. to filter on ICUs).

+

With additional columns (like a hospital name, the patients gender of even [well-defined] clinical properties) you can do a comparative analysis, as this tutorial will demonstrate too.

+
+

Patients +

+

To start with patients, we need a unique list of patients.

+
+patients <- unlist(lapply(LETTERS, paste0, 1:10))
+

The LETTERS object is available in R - it’s a vector with 26 characters: A to Z. The patients object we just created is now a vector of length 260, with values (patient IDs) varying from A1 to Z10. Now we we also set the gender of our patients, by putting the ID and the gender in a table:

+
+patients_table <- data.frame(patient_id = patients,
+                             gender = c(rep("M", 135),
+                                        rep("F", 125)))
+

The first 135 patient IDs are now male, the other 125 are female.

+
+
+

Dates +

+

Let’s pretend that our data consists of blood cultures isolates from between 1 January 2010 and 1 January 2018.

+
+dates <- seq(as.Date("2010-01-01"), as.Date("2018-01-01"), by = "day")
+

This dates object now contains all days in our date range.

+
+
Microorganisms +
+

For this tutorial, we will uses four different microorganisms: Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae:

+
+bacteria <- c("Escherichia coli", "Staphylococcus aureus",
+              "Streptococcus pneumoniae", "Klebsiella pneumoniae")
+
+
+
+

Put everything together +

+

Using the sample() function, we can randomly select items from all objects we defined earlier. To let our fake data reflect reality a bit, we will also approximately define the probabilities of bacteria and the antibiotic results, using the random_rsi() function.

+
+sample_size <- 20000
+data <- data.frame(date = sample(dates, size = sample_size, replace = TRUE),
+                   patient_id = sample(patients, size = sample_size, replace = TRUE),
+                   hospital = sample(c("Hospital A",
+                                       "Hospital B",
+                                       "Hospital C",
+                                       "Hospital D"),
+                                     size = sample_size, replace = TRUE,
+                                     prob = c(0.30, 0.35, 0.15, 0.20)),
+                   bacteria = sample(bacteria, size = sample_size, replace = TRUE,
+                                     prob = c(0.50, 0.25, 0.15, 0.10)),
+                   AMX = random_rsi(sample_size, prob_RSI = c(0.35, 0.60, 0.05)),
+                   AMC = random_rsi(sample_size, prob_RSI = c(0.15, 0.75, 0.10)),
+                   CIP = random_rsi(sample_size, prob_RSI = c(0.20, 0.80, 0.00)),
+                   GEN = random_rsi(sample_size, prob_RSI = c(0.08, 0.92, 0.00)))
+

Using the left_join() function from the dplyr package, we can ‘map’ the gender to the patient ID using the patients_table object we created earlier:

+
+data <- data %>% left_join(patients_table)
+

The resulting data set contains 20,000 blood culture isolates. With the head() function we can preview the first 6 rows of this data set:

+
+head(data)
+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
datepatient_idhospitalbacteriaAMXAMCCIPGENgender
2014-01-13A7Hospital CStaphylococcus aureusRSRSM
2010-07-17K10Hospital BEscherichia coliRRSSM
2013-12-06Z6Hospital AStreptococcus pneumoniaeRSRSF
2013-09-04U4Hospital CKlebsiella pneumoniaeRSRSF
2010-05-09B3Hospital AStaphylococcus aureusSSRSM
2013-12-21U3Hospital BEscherichia coliSRSRF
+

Now, let’s start the cleaning and the analysis!

+
+
+
+

Cleaning the data +

+

We also created a package dedicated to data cleaning and checking, called the cleaner package. It freq() function can be used to create frequency tables.

+

For example, for the gender variable:

+
+data %>% freq(gender)
+

Frequency table

+

Class: character
+Length: 20,000
+Available: 20,000 (100.0%, NA: 0 = 0.0%)
+Unique: 2

+

Shortest: 1
+Longest: 1

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +
ItemCountPercentCum. CountCum. Percent
1M10,40352.02%10,40352.02%
2F9,59747.99%20,000100.00%
+

So, we can draw at least two conclusions immediately. From a data scientists perspective, the data looks clean: only values M and F. From a researchers perspective: there are slightly more men. Nothing we didn’t already know.

+

The data is already quite clean, but we still need to transform some variables. The bacteria column now consists of text, and we want to add more variables based on microbial IDs later on. So, we will transform this column to valid IDs. The mutate() function of the dplyr package makes this really easy:

+
+data <- data %>%
+  mutate(bacteria = as.mo(bacteria))
+

We also want to transform the antibiotics, because in real life data we don’t know if they are really clean. The as.rsi() function ensures reliability and reproducibility in these kind of variables. The is.rsi.eligible() can check which columns are probably columns with R/SI test results. Using mutate() and across(), we can apply the transformation to the formal <rsi> class:

+
+is.rsi.eligible(data)
+# [1] FALSE FALSE FALSE FALSE  TRUE  TRUE  TRUE  TRUE FALSE
+colnames(data)[is.rsi.eligible(data)]
+# [1] "AMX" "AMC" "CIP" "GEN"
+
+data <- data %>%
+  mutate(across(where(is.rsi.eligible), as.rsi))
+

Finally, we will apply EUCAST rules on our antimicrobial results. In Europe, most medical microbiological laboratories already apply these rules. Our package features their latest insights on intrinsic resistance and exceptional phenotypes. Moreover, the eucast_rules() function can also apply additional rules, like forcing ampicillin = R when amoxicillin/clavulanic acid = R.

+

Because the amoxicillin (column AMX) and amoxicillin/clavulanic acid (column AMC) in our data were generated randomly, some rows will undoubtedly contain AMX = S and AMC = R, which is technically impossible. The eucast_rules() fixes this:

+
+data <- eucast_rules(data, col_mo = "bacteria", rules = "all")
+
+
+

Adding new variables +

+

Now that we have the microbial ID, we can add some taxonomic properties:

+
+data <- data %>% 
+  mutate(gramstain = mo_gramstain(bacteria),
+         genus = mo_genus(bacteria),
+         species = mo_species(bacteria))
+
+

First isolates +

+

We also need to know which isolates we can actually use for analysis.

+

To conduct an analysis of antimicrobial resistance, you must only include the first isolate of every patient per episode (Hindler et al., Clin Infect Dis. 2007). If you would not do this, you could easily get an overestimate or underestimate of the resistance of an antibiotic. Imagine that a patient was admitted with an MRSA and that it was found in 5 different blood cultures the following weeks (yes, some countries like the Netherlands have these blood drawing policies). The resistance percentage of oxacillin of all isolates would be overestimated, because you included this MRSA more than once. It would clearly be selection bias.

+

The Clinical and Laboratory Standards Institute (CLSI) appoints this as follows:

+
+

(…) When preparing a cumulative antibiogram to guide clinical decisions about empirical antimicrobial therapy of initial infections, only the first isolate of a given species per patient, per analysis period (eg, one year) should be included, irrespective of body site, antimicrobial susceptibility profile, or other phenotypical characteristics (eg, biotype). The first isolate is easily identified, and cumulative antimicrobial susceptibility test data prepared using the first isolate are generally comparable to cumulative antimicrobial susceptibility test data calculated by other methods, providing duplicate isolates are excluded.
M39-A4 Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data, 4th Edition. CLSI, 2014. Chapter 6.4

+
+

This AMR package includes this methodology with the first_isolate() function and is able to apply the four different methods as defined by Hindler et al. in 2007: phenotype-based, episode-based, patient-based, isolate-based. The right method depends on your goals and analysis, but the default phenotype-based method is in any case the method to properly correct for most duplicate isolates. This method also takes into account the antimicrobial susceptibility test results using all_microbials(). Read more about the methods on the first_isolate() page.

+

The outcome of the function can easily be added to our data:

+
+data <- data %>% 
+  mutate(first = first_isolate(info = TRUE))
+# Determining first isolates using an episode length of 365 days
+# ℹ Using column 'bacteria' as input for `col_mo`.
+# ℹ Using column 'date' as input for `col_date`.
+# ℹ Using column 'patient_id' as input for `col_patient_id`.
+# Basing inclusion on all antimicrobial results, using a points threshold of
+# 2
+# => Found 10,723 'phenotype-based' first isolates (53.6% of total where a
+#    microbial ID was available)
+

So only 53.6% is suitable for resistance analysis! We can now filter on it with the filter() function, also from the dplyr package:

+
+data_1st <- data %>% 
+  filter(first == TRUE)
+

For future use, the above two syntaxes can be shortened:

+
+data_1st <- data %>% 
+  filter_first_isolate()
+

So we end up with 10,723 isolates for analysis. Now our data looks like:

+
+head(data_1st)
+ ++++++++++++++++ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
datepatient_idhospitalbacteriaAMXAMCCIPGENgendergramstaingenusspeciesfirst
12014-01-13A7Hospital CB_STPHY_AURSRSRSMGram-positiveStaphylococcusaureusTRUE
32013-12-06Z6Hospital AB_STRPT_PNMNRRRRFGram-positiveStreptococcuspneumoniaeTRUE
52010-05-09B3Hospital AB_STPHY_AURSSSRSMGram-positiveStaphylococcusaureusTRUE
62013-12-21U3Hospital BB_ESCHR_COLIRRSRFGram-negativeEscherichiacoliTRUE
72011-06-10D8Hospital DB_STRPT_PNMNSSSRMGram-positiveStreptococcuspneumoniaeTRUE
92012-03-02K7Hospital BB_STRPT_PNMNRRSRMGram-positiveStreptococcuspneumoniaeTRUE
+

Time for the analysis!

+
+
+
+

Analysing the data +

+

You might want to start by getting an idea of how the data is distributed. It’s an important start, because it also decides how you will continue your analysis. Although this package contains a convenient function to make frequency tables, exploratory data analysis (EDA) is not the primary scope of this package. Use a package like DataExplorer for that, or read the free online book Exploratory Data Analysis with R by Roger D. Peng.

+
+

Dispersion of species +

+

To just get an idea how the species are distributed, create a frequency table with our freq() function. We created the genus and species column earlier based on the microbial ID. With paste(), we can concatenate them together.

+

The freq() function can be used like the base R language was intended:

+
+freq(paste(data_1st$genus, data_1st$species))
+

Or can be used like the dplyr way, which is easier readable:

+
+data_1st %>% freq(genus, species)
+

Frequency table

+

Class: character
+Length: 10,723
+Available: 10,723 (100.0%, NA: 0 = 0.0%)
+Unique: 4

+

Shortest: 16
+Longest: 24

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
ItemCountPercentCum. CountCum. Percent
1Escherichia coli4,68343.67%4,68343.67%
2Staphylococcus aureus2,72725.43%7,41069.10%
3Streptococcus pneumoniae2,10419.62%9,51488.73%
4Klebsiella pneumoniae1,20911.27%10,723100.00%
+
+
+

Overview of different bug/drug combinations +

+

Using tidyverse selections, you can also select or filter columns based on the antibiotic class they are in:

+
+data_1st %>% 
+  filter(any(aminoglycosides() == "R"))
+
# ℹ For `aminoglycosides()` using column 'GEN' (gentamicin)
+ +++++++++++++++ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
datepatient_idhospitalbacteriaAMXAMCCIPGENgendergramstaingenusspeciesfirst
2013-12-06Z6Hospital AB_STRPT_PNMNRRRRFGram-positiveStreptococcuspneumoniaeTRUE
2013-12-21U3Hospital BB_ESCHR_COLIRRSRFGram-negativeEscherichiacoliTRUE
2011-06-10D8Hospital DB_STRPT_PNMNSSSRMGram-positiveStreptococcuspneumoniaeTRUE
2012-03-02K7Hospital BB_STRPT_PNMNRRSRMGram-positiveStreptococcuspneumoniaeTRUE
2012-12-25W10Hospital BB_STRPT_PNMNSSSRFGram-positiveStreptococcuspneumoniaeTRUE
2011-02-13E5Hospital AB_STRPT_PNMNRRSRMGram-positiveStreptococcuspneumoniaeTRUE
+

If you want to get a quick glance of the number of isolates in different bug/drug combinations, you can use the bug_drug_combinations() function:

+
+data_1st %>% 
+  bug_drug_combinations() %>% 
+  head() # show first 6 rows
+
# ℹ Using column 'bacteria' as input for `col_mo`.
+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
moabSIRtotal
E. coliAMX222812123344683
E. coliAMC342315611044683
E. coliCIP3439012444683
E. coliGEN406406194683
K. pneumoniaeAMX0012091209
K. pneumoniaeAMC960462031209
+
+data_1st %>% 
+  select(bacteria, aminoglycosides()) %>% 
+  bug_drug_combinations()
+
# ℹ For `aminoglycosides()` using column 'GEN' (gentamicin)
+# ℹ Using column 'bacteria' as input for `col_mo`.
+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
moabSIRtotal
E. coliGEN406406194683
K. pneumoniaeGEN107501341209
S. aureusGEN242103062727
S. pneumoniaeGEN0021042104
+

This will only give you the crude numbers in the data. To calculate antimicrobial resistance in a more sensible way, also by correcting for too few results, we use the resistance() and susceptibility() functions.

+
+
+

Resistance percentages +

+

The functions resistance() and susceptibility() can be used to calculate antimicrobial resistance or susceptibility. For more specific analyses, the functions proportion_S(), proportion_SI(), proportion_I(), proportion_IR() and proportion_R() can be used to determine the proportion of a specific antimicrobial outcome.

+

All these functions contain a minimum argument, denoting the minimum required number of test results for returning a value. These functions will otherwise return NA. The default is minimum = 30, following the CLSI M39-A4 guideline for applying microbial epidemiology.

+

As per the EUCAST guideline of 2019, we calculate resistance as the proportion of R (proportion_R(), equal to resistance()) and susceptibility as the proportion of S and I (proportion_SI(), equal to susceptibility()). These functions can be used on their own:

+
+data_1st %>% resistance(AMX)
+# [1] 0.5465821
+

Or can be used in conjunction with group_by() and summarise(), both from the dplyr package:

+
+data_1st %>% 
+  group_by(hospital) %>% 
+  summarise(amoxicillin = resistance(AMX))
+ + + + + + + + + + + + + + + + + + + + + + + +
hospitalamoxicillin
Hospital A0.5332098
Hospital B0.5497618
Hospital C0.5499058
Hospital D0.5588652
+

Of course it would be very convenient to know the number of isolates responsible for the percentages. For that purpose the n_rsi() can be used, which works exactly like n_distinct() from the dplyr package. It counts all isolates available for every group (i.e. values S, I or R):

+
+data_1st %>% 
+  group_by(hospital) %>% 
+  summarise(amoxicillin = resistance(AMX),
+            available = n_rsi(AMX))
+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +
hospitalamoxicillinavailable
Hospital A0.53320983237
Hospital B0.54976183778
Hospital C0.54990581593
Hospital D0.55886522115
+

These functions can also be used to get the proportion of multiple antibiotics, to calculate empiric susceptibility of combination therapies very easily:

+
+data_1st %>% 
+  group_by(genus) %>% 
+  summarise(amoxiclav = susceptibility(AMC),
+            gentamicin = susceptibility(GEN),
+            amoxiclav_genta = susceptibility(AMC, GEN))
+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
genusamoxiclavgentamicinamoxiclav_genta
Escherichia0.76425370.86781980.9750160
Klebsiella0.83209260.88916460.9743590
Staphylococcus0.79207920.88778880.9845985
Streptococcus0.53612170.00000000.5361217
+

Or if you are curious for the resistance within certain antibiotic classes, use a antibiotic class selector such as penicillins(), which automatically will include the columns AMX and AMC of our data:

+
+data_1st %>% 
+  # group by hospital
+  group_by(hospital) %>% 
+  #                / -> select all penicillins in the data for calculation
+  #                |              / -> use resistance() for all peni's per hospital
+  #                |              |           / -> print as percentages
+  summarise(across(penicillins(), resistance, as_percent = TRUE)) %>% 
+  # format the antibiotic column names, using so-called snake case,
+  # so 'Amoxicillin/clavulanic acid' becomes 'amoxicillin_clavulanic_acid'
+  rename_with(set_ab_names, penicillins())
+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +
hospitalamoxicillinamoxicillin_clavulanic_acid
Hospital A53.3%26.2%
Hospital B55.0%27.0%
Hospital C55.0%25.5%
Hospital D55.9%27.3%
+

To make a transition to the next part, let’s see how differences in the previously calculated combination therapies could be plotted:

+
+data_1st %>% 
+  group_by(genus) %>% 
+  summarise("1. Amoxi/clav" = susceptibility(AMC),
+            "2. Gentamicin" = susceptibility(GEN),
+            "3. Amoxi/clav + genta" = susceptibility(AMC, GEN)) %>% 
+  # pivot_longer() from the tidyr package "lengthens" data:
+  tidyr::pivot_longer(-genus, names_to = "antibiotic") %>% 
+  ggplot(aes(x = genus,
+             y = value,
+             fill = antibiotic)) +
+  geom_col(position = "dodge2")
+

+
+
+

Plots +

+

To show results in plots, most R users would nowadays use the ggplot2 package. This package lets you create plots in layers. You can read more about it on their website. A quick example would look like these syntaxes:

+
+ggplot(data = a_data_set,
+       mapping = aes(x = year,
+                     y = value)) +
+  geom_col() +
+  labs(title = "A title",
+       subtitle = "A subtitle",
+       x = "My X axis",
+       y = "My Y axis")
+
+# or as short as:
+ggplot(a_data_set) +
+  geom_bar(aes(year))
+

The AMR package contains functions to extend this ggplot2 package, for example geom_rsi(). It automatically transforms data with count_df() or proportion_df() and show results in stacked bars. Its simplest and shortest example:

+
+ggplot(data_1st) +
+  geom_rsi(translate_ab = FALSE)
+

+

Omit the translate_ab = FALSE to have the antibiotic codes (AMX, AMC, CIP, GEN) translated to official WHO names (amoxicillin, amoxicillin/clavulanic acid, ciprofloxacin, gentamicin).

+

If we group on e.g. the genus column and add some additional functions from our package, we can create this:

+
+# group the data on `genus`
+ggplot(data_1st %>% group_by(genus)) + 
+  # create bars with genus on x axis
+  # it looks for variables with class `rsi`,
+  # of which we have 4 (earlier created with `as.rsi`)
+  geom_rsi(x = "genus") + 
+  # split plots on antibiotic
+  facet_rsi(facet = "antibiotic") +
+  # set colours to the R/SI interpretations (colour-blind friendly)
+  scale_rsi_colours() +
+  # show percentages on y axis
+  scale_y_percent(breaks = 0:4 * 25) +
+  # turn 90 degrees, to make it bars instead of columns
+  coord_flip() +
+  # add labels
+  labs(title = "Resistance per genus and antibiotic", 
+       subtitle = "(this is fake data)") +
+  # and print genus in italic to follow our convention
+  # (is now y axis because we turned the plot)
+  theme(axis.text.y = element_text(face = "italic"))
+

+

To simplify this, we also created the ggplot_rsi() function, which combines almost all above functions:

+
+data_1st %>% 
+  group_by(genus) %>%
+  ggplot_rsi(x = "genus",
+             facet = "antibiotic",
+             breaks = 0:4 * 25,
+             datalabels = FALSE) +
+  coord_flip()
+

+
+

Plotting MIC and disk diffusion values +

+

The AMR package also extends the plot() and ggplot2::autoplot() functions for plotting minimum inhibitory concentrations (MIC, created with as.mic()) and disk diffusion diameters (created with as.disk()).

+

With the random_mic() and random_disk() functions, we can generate sampled values for the new data types (S3 classes) <mic> and <disk>:

+
+mic_values <- random_mic(size = 100)
+mic_values
+# Class <mic>
+#   [1] 32      64      128     128     64      8       32      0.002   0.025  
+#  [10] 0.5     32      <=0.001 2       128     0.01    1       2       0.01   
+#  [19] 128     0.5     4       0.002   0.125   256     0.0625  4       0.002  
+#  [28] 0.005   4       0.002   32      0.01    0.0625  0.25    2       64     
+#  [37] 0.0625  0.5     256     4       1       0.025   128     0.0625  16     
+#  [46] 0.5     0.005   0.01    1       2       0.01    2       8       0.125  
+#  [55] 0.25    256     0.0625  0.025   0.002   8       <=0.001 1       0.002  
+#  [64] 256     8       4       0.005   0.025   4       0.002   <=0.001 2      
+#  [73] 256     0.005   256     2       4       16      128     256     <=0.001
+#  [82] 1       2       1       1       <=0.001 0.5     4       0.25    32     
+#  [91] 0.002   0.0625  0.01    32      0.005   0.01    2       64      64     
+# [100] 2
+
+# base R:
+plot(mic_values)
+

+
+# ggplot2:
+autoplot(mic_values)
+

+

But we could also be more specific, by generating MICs that are likely to be found in E. coli for ciprofloxacin:

+
+mic_values <- random_mic(size = 100, mo = "E. coli", ab = "cipro")
+

For the plot() and autoplot() function, we can define the microorganism and an antimicrobial agent the same way. This will add the interpretation of those values according to a chosen guidelines (defaults to the latest EUCAST guideline).

+

Default colours are colour-blind friendly, while maintaining the convention that e.g. ‘susceptible’ should be green and ‘resistant’ should be red:

+
+# base R:
+plot(mic_values, mo = "E. coli", ab = "cipro")
+

+
+# ggplot2:
+autoplot(mic_values, mo = "E. coli", ab = "cipro")
+

+

For disk diffusion values, there is not much of a difference in plotting:

+
+disk_values <- random_disk(size = 100, mo = "E. coli", ab = "cipro")
+# ℹ Function `as.mo()` is uncertain about "E. coli" (assuming Escherichia
+#   coli). Run `mo_uncertainties()` to review this.
+disk_values
+# Class <disk>
+#   [1] 28 22 30 19 23 20 17 21 22 18 18 27 18 20 24 28 30 20 29 31 22 31 23 24 17
+#  [26] 23 18 17 25 30 28 23 30 23 30 31 18 26 26 26 27 17 30 18 27 31 17 24 20 26
+#  [51] 30 21 26 27 20 23 28 29 17 29 27 24 22 27 28 27 22 30 18 28 25 18 25 18 31
+#  [76] 29 25 17 31 20 20 21 24 24 30 28 30 31 20 30 27 19 24 17 22 30 31 27 28 24
+
+# base R:
+plot(disk_values, mo = "E. coli", ab = "cipro")
+

+

And when using the ggplot2 package, but now choosing the latest implemented CLSI guideline (notice that the EUCAST-specific term “Susceptible, incr. exp.” has changed to “Intermediate”):

+
+autoplot(disk_values,
+       mo = "E. coli",
+       ab = "cipro",
+       guideline = "CLSI")
+

+
+
+
+

Independence test +

+

The next example uses the example_isolates data set. This is a data set included with this package and contains 2,000 microbial isolates with their full antibiograms. It reflects reality and can be used to practice AMR data analysis.

+

We will compare the resistance to fosfomycin (column FOS) in hospital A and D. The input for the fisher.test() can be retrieved with a transformation like this:

+
+# use package 'tidyr' to pivot data:
+library(tidyr)
+
+check_FOS <- example_isolates %>%
+  filter(hospital_id %in% c("A", "D")) %>% # filter on only hospitals A and D
+  select(hospital_id, FOS) %>%             # select the hospitals and fosfomycin
+  group_by(hospital_id) %>%                # group on the hospitals
+  count_df(combine_SI = TRUE) %>%          # count all isolates per group (hospital_id)
+  pivot_wider(names_from = hospital_id,    # transform output so A and D are columns
+              values_from = value) %>%     
+  select(A, D) %>%                         # and only select these columns
+  as.matrix()                              # transform to a good old matrix for fisher.test()
+
+check_FOS
+#       A  D
+# [1,] 25 77
+# [2,] 24 33
+

We can apply the test now with:

+
+# do Fisher's Exact Test
+fisher.test(check_FOS)                            
+# 
+#   Fisher's Exact Test for Count Data
+# 
+# data:  check_FOS
+# p-value = 0.03104
+# alternative hypothesis: true odds ratio is not equal to 1
+# 95 percent confidence interval:
+#  0.2111489 0.9485124
+# sample estimates:
+# odds ratio 
+#  0.4488318
+

As can be seen, the p value is 0.031, which means that the fosfomycin resistance found in isolates from patients in hospital A and D are really different.

+
+
+
+
+ + + + +
+ + + + + + + diff --git a/articles/AMR_files/figure-html/disk_plots-1.png b/articles/AMR_files/figure-html/disk_plots-1.png new file mode 100644 index 00000000..c29fbb45 Binary files /dev/null and b/articles/AMR_files/figure-html/disk_plots-1.png differ diff --git a/articles/AMR_files/figure-html/disk_plots_mo_ab-1.png b/articles/AMR_files/figure-html/disk_plots_mo_ab-1.png new file mode 100644 index 00000000..85292cff Binary files /dev/null and b/articles/AMR_files/figure-html/disk_plots_mo_ab-1.png differ diff --git a/articles/AMR_files/figure-html/mic_plots-1.png b/articles/AMR_files/figure-html/mic_plots-1.png new file mode 100644 index 00000000..b5a97d72 Binary files /dev/null and b/articles/AMR_files/figure-html/mic_plots-1.png differ diff --git a/articles/AMR_files/figure-html/mic_plots-2.png b/articles/AMR_files/figure-html/mic_plots-2.png new file mode 100644 index 00000000..ee500bbc Binary files /dev/null and b/articles/AMR_files/figure-html/mic_plots-2.png differ diff --git a/articles/AMR_files/figure-html/mic_plots_mo_ab-1.png b/articles/AMR_files/figure-html/mic_plots_mo_ab-1.png new file mode 100644 index 00000000..efdebadf Binary files /dev/null and b/articles/AMR_files/figure-html/mic_plots_mo_ab-1.png differ diff --git a/articles/AMR_files/figure-html/mic_plots_mo_ab-2.png b/articles/AMR_files/figure-html/mic_plots_mo_ab-2.png new file mode 100644 index 00000000..5e887406 Binary files /dev/null and b/articles/AMR_files/figure-html/mic_plots_mo_ab-2.png differ diff --git a/articles/AMR_files/figure-html/plot 1-1.png b/articles/AMR_files/figure-html/plot 1-1.png new file mode 100644 index 00000000..3a66ccbf Binary files /dev/null and b/articles/AMR_files/figure-html/plot 1-1.png differ diff --git a/articles/AMR_files/figure-html/plot 3-1.png b/articles/AMR_files/figure-html/plot 3-1.png new file mode 100644 index 00000000..64e71de3 Binary files /dev/null and b/articles/AMR_files/figure-html/plot 3-1.png differ diff --git a/articles/AMR_files/figure-html/plot 4-1.png b/articles/AMR_files/figure-html/plot 4-1.png new file mode 100644 index 00000000..9537609b Binary files /dev/null and b/articles/AMR_files/figure-html/plot 4-1.png differ diff --git a/articles/AMR_files/figure-html/plot 5-1.png b/articles/AMR_files/figure-html/plot 5-1.png new file mode 100644 index 00000000..afc85baa Binary files /dev/null and b/articles/AMR_files/figure-html/plot 5-1.png differ diff --git a/articles/EUCAST.html b/articles/EUCAST.html new file mode 100644 index 00000000..95697948 --- /dev/null +++ b/articles/EUCAST.html @@ -0,0 +1,385 @@ + + + + + + + + +How to apply EUCAST rules • AMR (for R) + + + + + + + + + + + + + + + + + + + + + + Skip to contents + + +
+ + + + +
+
+

How to apply EUCAST rules

+ + + Source: vignettes/EUCAST.Rmd +
EUCAST.Rmd
+
+ + + +
+

Introduction +

+

What are EUCAST rules? The European Committee on Antimicrobial Susceptibility Testing (EUCAST) states on their website:

+
+

EUCAST expert rules are a tabulated collection of expert knowledge on intrinsic resistances, exceptional resistance phenotypes and interpretive rules that may be applied to antimicrobial susceptibility testing in order to reduce errors and make appropriate recommendations for reporting particular resistances.

+
+

In Europe, a lot of medical microbiological laboratories already apply these rules (Brown et al., 2015). Our package features their latest insights on intrinsic resistance and unusual phenotypes (v3.3, 2021).

+

Moreover, the eucast_rules() function we use for this purpose can also apply additional rules, like forcing ampicillin = R in isolates when amoxicillin/clavulanic acid = R.

+
+
+

Examples +

+

These rules can be used to discard impossible bug-drug combinations in your data. For example, Klebsiella produces beta-lactamase that prevents ampicillin (or amoxicillin) from working against it. In other words, practically every strain of Klebsiella is resistant to ampicillin.

+

Sometimes, laboratory data can still contain such strains with ampicillin being susceptible to ampicillin. This could be because an antibiogram is available before an identification is available, and the antibiogram is then not re-interpreted based on the identification (namely, Klebsiella). EUCAST expert rules solve this, that can be applied using eucast_rules():

+
+oops <- data.frame(mo = c("Klebsiella", 
+                          "Escherichia"),
+                   ampicillin = "S")
+oops
+#            mo ampicillin
+# 1  Klebsiella          S
+# 2 Escherichia          S
+
+eucast_rules(oops, info = FALSE)
+#            mo ampicillin
+# 1  Klebsiella          R
+# 2 Escherichia          S
+

A more convenient function is mo_is_intrinsic_resistant() that uses the same guideline, but allows to check for one or more specific microorganisms or antibiotics:

+
+mo_is_intrinsic_resistant(c("Klebsiella", "Escherichia"),
+                          "ampicillin")
+# [1]  TRUE FALSE
+
+mo_is_intrinsic_resistant("Klebsiella",
+                          c("ampicillin", "kanamycin"))
+# [1]  TRUE FALSE
+

EUCAST rules can not only be used for correction, they can also be used for filling in known resistance and susceptibility based on results of other antimicrobials drugs. This process is called interpretive reading, is basically a form of imputation, and is part of the eucast_rules() function as well:

+
+data <- data.frame(mo = c("Staphylococcus aureus",
+                          "Enterococcus faecalis",
+                          "Escherichia coli",
+                          "Klebsiella pneumoniae",
+                          "Pseudomonas aeruginosa"),
+                   VAN = "-",       # Vancomycin
+                   AMX = "-",       # Amoxicillin
+                   COL = "-",       # Colistin
+                   CAZ = "-",       # Ceftazidime
+                   CXM = "-",       # Cefuroxime
+                   PEN = "S",       # Benzylenicillin
+                   FOX = "S",       # Cefoxitin
+                   stringsAsFactors = FALSE)
+
+data
+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
moVANAMXCOLCAZCXMPENFOX
Staphylococcus aureus-----SS
Enterococcus faecalis-----SS
Escherichia coli-----SS
Klebsiella pneumoniae-----SS
Pseudomonas aeruginosa-----SS
+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
moVANAMXCOLCAZCXMPENFOX
Staphylococcus aureus-SRRSSS
Enterococcus faecalis--RRRSR
Escherichia coliR----RS
Klebsiella pneumoniaeRR---RS
Pseudomonas aeruginosaRR--RRR
+
+
+
+ + + + +
+ + + + + + + diff --git a/articles/MDR.html b/articles/MDR.html new file mode 100644 index 00000000..32c61427 --- /dev/null +++ b/articles/MDR.html @@ -0,0 +1,423 @@ + + + + + + + + +How to determine multi-drug resistance (MDR) • AMR (for R) + + + + + + + + + + + + + + + + + + + + + + Skip to contents + + +
+ + + + +
+
+

How to determine multi-drug resistance (MDR)

+ + + Source: vignettes/MDR.Rmd +
MDR.Rmd
+
+ + + +

With the function mdro(), you can determine which micro-organisms are multi-drug resistant organisms (MDRO).

+
+

Type of input +

+

The mdro() function takes a data set as input, such as a regular data.frame. It tries to automatically determine the right columns for info about your isolates, such as the name of the species and all columns with results of antimicrobial agents. See the help page for more info about how to set the right settings for your data with the command ?mdro.

+

For WHONET data (and most other data), all settings are automatically set correctly.

+
+
+

Guidelines +

+

The mdro() function support multiple guidelines. You can select a guideline with the guideline parameter. Currently supported guidelines are (case-insensitive):

+
    +
  • +

    guideline = "CMI2012" (default)

    +

    Magiorakos AP, Srinivasan A et al. “Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance.” Clinical Microbiology and Infection (2012) (link)

    +
    • +
  • +

    guideline = "EUCAST3.2" (or simply guideline = "EUCAST")

    +

    The European international guideline - EUCAST Expert Rules Version 3.2 “Intrinsic Resistance and Unusual Phenotypes” (link)

    +
    • +
  • +

    guideline = "EUCAST3.1"

    +

    The European international guideline - EUCAST Expert Rules Version 3.1 “Intrinsic Resistance and Exceptional Phenotypes Tables” (link)

    +
    • +
  • +

    guideline = "TB"

    +

    The international guideline for multi-drug resistant tuberculosis - World Health Organization “Companion handbook to the WHO guidelines for the programmatic management of drug-resistant tuberculosis” (link)

    +
    • +
  • +

    guideline = "MRGN"

    +

    The German national guideline - Mueller et al. (2015) Antimicrobial Resistance and Infection Control 4:7. DOI: 10.1186/s13756-015-0047-6

    +
    • +
  • +

    guideline = "BRMO"

    +

    The Dutch national guideline - Rijksinstituut voor Volksgezondheid en Milieu “WIP-richtlijn BRMO (Bijzonder Resistente Micro-Organismen) (ZKH)” (link)

    +
    • +
+

Please suggest your own (country-specific) guidelines by letting us know: https://github.com/msberends/AMR/issues/new.

+
+

Custom Guidelines +

+

You can also use your own custom guideline. Custom guidelines can be set with the custom_mdro_guideline() function. This is of great importance if you have custom rules to determine MDROs in your hospital, e.g., rules that are dependent on ward, state of contact isolation or other variables in your data.

+

If you are familiar with case_when() of the dplyr package, you will recognise the input method to set your own rules. Rules must be set using what R considers to be the ‘formula notation’:

+
+custom <- custom_mdro_guideline(CIP == "R" & age > 60 ~ "Elderly Type A",
+                                ERY == "R" & age > 60 ~ "Elderly Type B")
+

If a row/an isolate matches the first rule, the value after the first ~ (in this case ‘Elderly Type A’) will be set as MDRO value. Otherwise, the second rule will be tried and so on. The maximum number of rules is unlimited.

+

You can print the rules set in the console for an overview. Colours will help reading it if your console supports colours.

+
+custom
+# A set of custom MDRO rules:
+#   1. If CIP is "R" and age is higher than 60 then: Elderly Type A
+#   2. If ERY is "R" and age is higher than 60 then: Elderly Type B
+#   3. Otherwise: Negative
+# 
+# Unmatched rows will return NA.
+# Results will be of class <factor>, with ordered levels: Negative < Elderly Type A < Elderly Type B
+

The outcome of the function can be used for the guideline argument in the mdro() function:

+
+x <- mdro(example_isolates, guideline = custom)
+table(x)
+# x
+#       Negative Elderly Type A Elderly Type B 
+#           1070            198            732
+

The rules set (the custom object in this case) could be exported to a shared file location using saveRDS() if you collaborate with multiple users. The custom rules set could then be imported using readRDS().

+
+
+
+

Examples +

+

The mdro() function always returns an ordered factor for predefined guidelines. For example, the output of the default guideline by Magiorakos et al. returns a factor with levels ‘Negative’, ‘MDR’, ‘XDR’ or ‘PDR’ in that order.

+

The next example uses the example_isolates data set. This is a data set included with this package and contains full antibiograms of 2,000 microbial isolates. It reflects reality and can be used to practise AMR data analysis. If we test the MDR/XDR/PDR guideline on this data set, we get:

+
+library(dplyr)   # to support pipes: %>%
+library(cleaner) # to create frequency tables
+
+example_isolates %>% 
+  mdro() %>% 
+  freq() # show frequency table of the result
+# Warning: in `mdro()`: NA introduced for isolates where the available percentage of
+# antimicrobial classes was below 50% (set with `pct_required_classes`)
+

(16 isolates had no test results)

+

Frequency table

+

Class: factor > ordered (numeric)
+Length: 2,000
+Levels: 4: Negative < Multi-drug-resistant (MDR) < Extensively drug-resistant …
+Available: 1,729 (86.45%, NA: 271 = 13.55%)
+Unique: 2

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +
ItemCountPercentCum. CountCum. Percent
1Negative160192.60%160192.60%
2Multi-drug-resistant (MDR)1287.40%1729100.00%
+

For another example, I will create a data set to determine multi-drug resistant TB:

+
+# random_rsi() is a helper function to generate
+# a random vector with values S, I and R
+my_TB_data <- data.frame(rifampicin = random_rsi(5000),
+                         isoniazid = random_rsi(5000),
+                         gatifloxacin = random_rsi(5000),
+                         ethambutol = random_rsi(5000),
+                         pyrazinamide = random_rsi(5000),
+                         moxifloxacin = random_rsi(5000),
+                         kanamycin = random_rsi(5000))
+

Because all column names are automatically verified for valid drug names or codes, this would have worked exactly the same way:

+
+my_TB_data <- data.frame(RIF = random_rsi(5000),
+                         INH = random_rsi(5000),
+                         GAT = random_rsi(5000),
+                         ETH = random_rsi(5000),
+                         PZA = random_rsi(5000),
+                         MFX = random_rsi(5000),
+                         KAN = random_rsi(5000))
+

The data set now looks like this:

+
+head(my_TB_data)
+#   rifampicin isoniazid gatifloxacin ethambutol pyrazinamide moxifloxacin
+# 1          I         I            S          S            I            R
+# 2          I         R            R          S            I            I
+# 3          R         I            S          R            R            S
+# 4          I         S            I          S            I            S
+# 5          S         R            S          I            S            R
+# 6          I         S            I          I            S            S
+#   kanamycin
+# 1         I
+# 2         R
+# 3         S
+# 4         R
+# 5         S
+# 6         S
+

We can now add the interpretation of MDR-TB to our data set. You can use:

+
+mdro(my_TB_data, guideline = "TB")
+

or its shortcut mdr_tb():

+
+my_TB_data$mdr <- mdr_tb(my_TB_data)
+# ℹ No column found as input for `col_mo`, assuming all rows contain
+#   Mycobacterium tuberculosis.
+

Create a frequency table of the results:

+
+freq(my_TB_data$mdr)
+

Frequency table

+

Class: factor > ordered (numeric)
+Length: 5,000
+Levels: 5: Negative < Mono-resistant < Poly-resistant < Multi-drug-resistant <…
+Available: 5,000 (100.0%, NA: 0 = 0.0%)
+Unique: 5

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
ItemCountPercentCum. CountCum. Percent
1Mono-resistant319363.86%319363.86%
2Negative99619.92%418983.78%
3Multi-drug-resistant4509.00%463992.78%
4Poly-resistant2414.82%488097.60%
5Extensively drug-resistant1202.40%5000100.00%
+
+
+
+ + + + +
+ + + + + + + diff --git a/articles/PCA.html b/articles/PCA.html new file mode 100644 index 00000000..602506f8 --- /dev/null +++ b/articles/PCA.html @@ -0,0 +1,323 @@ + + + + + + + + +How to conduct principal component analysis (PCA) for AMR • AMR (for R) + + + + + + + + + + + + + + + + + + + + + + Skip to contents + + +
+ + + + +
+
+

How to conduct principal component analysis (PCA) for AMR

+ + + Source: vignettes/PCA.Rmd +
PCA.Rmd
+
+ + + +

NOTE: This page will be updated soon, as the pca() function is currently being developed.

+
+

Introduction +

+
+
+

Transforming +

+

For PCA, we need to transform our AMR data first. This is what the example_isolates data set in this package looks like:

+
+library(AMR)
+library(dplyr)
+glimpse(example_isolates)
+# Rows: 2,000
+# Columns: 49
+# $ date            <date> 2002-01-02, 2002-01-03, 2002-01-07, 2002-01-07, 2002-…
+# $ hospital_id     <fct> D, D, B, B, B, B, D, D, B, B, D, D, D, D, D, B, B, B, …
+# $ ward_icu        <lgl> FALSE, FALSE, TRUE, TRUE, TRUE, TRUE, FALSE, FALSE, TR…
+# $ ward_clinical   <lgl> TRUE, TRUE, FALSE, FALSE, FALSE, FALSE, TRUE, TRUE, FA…
+# $ ward_outpatient <lgl> FALSE, FALSE, FALSE, FALSE, FALSE, FALSE, FALSE, FALSE…
+# $ age             <dbl> 65, 65, 45, 45, 45, 45, 78, 78, 45, 79, 67, 67, 71, 71…
+# $ gender          <chr> "F", "F", "F", "F", "F", "F", "M", "M", "F", "F", "M",…
+# $ patient_id      <chr> "A77334", "A77334", "067927", "067927", "067927", "067…
+# $ mo              <mo> "B_ESCHR_COLI", "B_ESCHR_COLI", "B_STPHY_EPDR", "B_STPH…
+# $ PEN             <rsi> R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, …
+# $ OXA             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ FLC             <rsi> NA, NA, R, R, R, R, S, S, R, S, S, S, NA, NA, NA, NA, …
+# $ AMX             <rsi> NA, NA, NA, NA, NA, NA, R, R, NA, NA, NA, NA, NA, NA, …
+# $ AMC             <rsi> I, I, NA, NA, NA, NA, S, S, NA, NA, S, S, I, I, R, I, …
+# $ AMP             <rsi> NA, NA, NA, NA, NA, NA, R, R, NA, NA, NA, NA, NA, NA, …
+# $ TZP             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ CZO             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ FEP             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ CXM             <rsi> I, I, R, R, R, R, S, S, R, S, S, S, S, S, NA, S, S, R,…
+# $ FOX             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ CTX             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, S, S, …
+# $ CAZ             <rsi> NA, NA, R, R, R, R, R, R, R, R, R, R, NA, NA, NA, S, S…
+# $ CRO             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, S, S, …
+# $ GEN             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ TOB             <rsi> NA, NA, NA, NA, NA, NA, S, S, NA, NA, NA, NA, S, S, NA…
+# $ AMK             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ KAN             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ TMP             <rsi> R, R, S, S, R, R, R, R, S, S, NA, NA, S, S, S, S, S, R…
+# $ SXT             <rsi> R, R, S, S, NA, NA, NA, NA, S, S, NA, NA, S, S, S, S, …
+# $ NIT             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ FOS             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ LNZ             <rsi> R, R, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, R, R, R,…
+# $ CIP             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, S, S, NA, NA, NA, NA, …
+# $ MFX             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ VAN             <rsi> R, R, S, S, S, S, S, S, S, S, NA, NA, R, R, R, R, R, S…
+# $ TEC             <rsi> R, R, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, R, R, R,…
+# $ TCY             <rsi> R, R, S, S, S, S, S, S, S, I, S, S, NA, NA, I, R, R, S…
+# $ TGC             <rsi> NA, NA, S, S, S, S, S, S, S, NA, S, S, NA, NA, NA, R, …
+# $ DOX             <rsi> NA, NA, S, S, S, S, S, S, S, NA, S, S, NA, NA, NA, R, …
+# $ ERY             <rsi> R, R, R, R, R, R, S, S, R, S, S, S, R, R, R, R, R, R, …
+# $ CLI             <rsi> R, R, NA, NA, NA, R, NA, NA, NA, NA, NA, NA, R, R, R, …
+# $ AZM             <rsi> R, R, R, R, R, R, S, S, R, S, S, S, R, R, R, R, R, R, …
+# $ IPM             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, S, S, …
+# $ MEM             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ MTR             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ CHL             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ COL             <rsi> NA, NA, R, R, R, R, R, R, R, R, R, R, NA, NA, NA, R, R…
+# $ MUP             <rsi> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
+# $ RIF             <rsi> R, R, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, R, R, R,…
+

Now to transform this to a data set with only resistance percentages per taxonomic order and genus:

+
+resistance_data <- example_isolates %>% 
+  group_by(order = mo_order(mo),       # group on anything, like order
+           genus = mo_genus(mo)) %>%   #  and genus as we do here
+  summarise_if(is.rsi, resistance) %>% # then get resistance of all drugs
+  select(order, genus, AMC, CXM, CTX, 
+         CAZ, GEN, TOB, TMP, SXT)      # and select only relevant columns
+
+head(resistance_data)
+# # A tibble: 6 × 10
+# # Groups:   order [5]
+#   order             genus          AMC   CXM   CTX   CAZ   GEN   TOB   TMP   SXT
+#   <chr>             <chr>        <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl>
+# 1 (unknown order)   (unknown ge…    NA    NA    NA    NA    NA    NA    NA    NA
+# 2 Actinomycetales   Schaalia        NA    NA    NA    NA    NA    NA    NA    NA
+# 3 Bacteroidales     Bacteroides     NA    NA    NA    NA    NA    NA    NA    NA
+# 4 Campylobacterales Campylobact…    NA    NA    NA    NA    NA    NA    NA    NA
+# 5 Caryophanales     Gemella         NA    NA    NA    NA    NA    NA    NA    NA
+# 6 Caryophanales     Listeria        NA    NA    NA    NA    NA    NA    NA    NA
+
+
+

Perform principal component analysis +

+

The new pca() function will automatically filter on rows that contain numeric values in all selected variables, so we now only need to do:

+
+pca_result <- pca(resistance_data)
+# ℹ Columns selected for PCA: "AMC", "CAZ", "CTX", "CXM", "GEN", "SXT", "TMP"
+#   and "TOB". Total observations available: 7.
+

The result can be reviewed with the good old summary() function:

+
+summary(pca_result)
+# Groups (n=4, named as 'order'):
+# [1] "Caryophanales"    "Enterobacterales" "Lactobacillales"  "Pseudomonadales"
+# Importance of components:
+#                           PC1    PC2    PC3     PC4     PC5     PC6       PC7
+# Standard deviation     2.1539 1.6807 0.6138 0.33879 0.20808 0.03140 5.121e-17
+# Proportion of Variance 0.5799 0.3531 0.0471 0.01435 0.00541 0.00012 0.000e+00
+# Cumulative Proportion  0.5799 0.9330 0.9801 0.99446 0.99988 1.00000 1.000e+00
+
# Groups (n=4, named as 'order'):
+# [1] "Caryophanales"    "Enterobacterales" "Lactobacillales"  "Pseudomonadales"
+

Good news. The first two components explain a total of 93.3% of the variance (see the PC1 and PC2 values of the Proportion of Variance. We can create a so-called biplot with the base R biplot() function, to see which antimicrobial resistance per drug explain the difference per microorganism.

+
+
+

Plotting the results +

+
+biplot(pca_result)
+

+

But we can’t see the explanation of the points. Perhaps this works better with our new ggplot_pca() function, that automatically adds the right labels and even groups:

+
+ggplot_pca(pca_result)
+

+

You can also print an ellipse per group, and edit the appearance:

+
+ggplot_pca(pca_result, ellipse = TRUE) +
+  ggplot2::labs(title = "An AMR/PCA biplot!")
+

+
+
+
+ + + + +
+ + + + + + + diff --git a/articles/PCA_files/figure-html/unnamed-chunk-5-1.png b/articles/PCA_files/figure-html/unnamed-chunk-5-1.png new file mode 100644 index 00000000..34be1bb1 Binary files /dev/null and b/articles/PCA_files/figure-html/unnamed-chunk-5-1.png differ diff --git a/articles/PCA_files/figure-html/unnamed-chunk-6-1.png b/articles/PCA_files/figure-html/unnamed-chunk-6-1.png new file mode 100644 index 00000000..e4d7127e Binary files /dev/null and b/articles/PCA_files/figure-html/unnamed-chunk-6-1.png differ diff --git a/articles/PCA_files/figure-html/unnamed-chunk-7-1.png b/articles/PCA_files/figure-html/unnamed-chunk-7-1.png new file mode 100644 index 00000000..fa91144f Binary files /dev/null and b/articles/PCA_files/figure-html/unnamed-chunk-7-1.png differ diff --git a/articles/SPSS.html b/articles/SPSS.html new file mode 100644 index 00000000..53c77471 --- /dev/null +++ b/articles/SPSS.html @@ -0,0 +1,397 @@ + + + + + + + + +How to import data from SPSS / SAS / Stata • AMR (for R) + + + + + + + + + + + + + + + + + + + + + + Skip to contents + + +
+ + + + +
+
+

How to import data from SPSS / SAS / Stata

+

Dr. Matthijs Berends

+ +

21 August 2022

+ + Source: vignettes/SPSS.Rmd +
SPSS.Rmd
+
+ + + +
+

SPSS / SAS / Stata +

+

SPSS (Statistical Package for the Social Sciences) is probably the most well-known software package for statistical analysis. SPSS is easier to learn than R, because in SPSS you only have to click a menu to run parts of your analysis. Because of its user-friendliness, it is taught at universities and particularly useful for students who are new to statistics. From my experience, I would guess that pretty much all (bio)medical students know it at the time they graduate. SAS and Stata are comparable statistical packages popular in big industries.

+
+
+

Compared to R +

+

As said, SPSS is easier to learn than R. But SPSS, SAS and Stata come with major downsides when comparing it with R:

+
    +
  • +

    R is highly modular.

    +

    The official R network (CRAN) features more than 16,000 packages at the time of writing, our AMR package being one of them. All these packages were peer-reviewed before publication. Aside from this official channel, there are also developers who choose not to submit to CRAN, but rather keep it on their own public repository, like GitHub. So there may even be a lot more than 14,000 packages out there.

    +

    Bottom line is, you can really extend it yourself or ask somebody to do this for you. Take for example our AMR package. Among other things, it adds reliable reference data to R to help you with the data cleaning and analysis. SPSS, SAS and Stata will never know what a valid MIC value is or what the Gram stain of E. coli is. Or that all species of Klebiella are resistant to amoxicillin and that Floxapen® is a trade name of flucloxacillin. These facts and properties are often needed to clean existing data, which would be very inconvenient in a software package without reliable reference data. See below for a demonstration.

    +
    • +
  • +

    R is extremely flexible.

    +

    Because you write the syntax yourself, you can do anything you want. The flexibility in transforming, arranging, grouping and summarising data, or drawing plots, is endless - with SPSS, SAS or Stata you are bound to their algorithms and format styles. They may be a bit flexible, but you can probably never create that very specific publication-ready plot without using other (paid) software. If you sometimes write syntaxes in SPSS to run a complete analysis or to ‘automate’ some of your work, you could do this a lot less time in R. You will notice that writing syntaxes in R is a lot more nifty and clever than in SPSS. Still, as working with any statistical package, you will have to have knowledge about what you are doing (statistically) and what you are willing to accomplish.

    +
    • +
  • +

    R can be easily automated.

    +

    Over the last years, R Markdown has really made an interesting development. With R Markdown, you can very easily produce reports, whether the format has to be Word, PowerPoint, a website, a PDF document or just the raw data to Excel. It even allows the use of a reference file containing the layout style (e.g. fonts and colours) of your organisation. I use this a lot to generate weekly and monthly reports automatically. Just write the code once and enjoy the automatically updated reports at any interval you like.

    +

    For an even more professional environment, you could create Shiny apps: live manipulation of data using a custom made website. The webdesign knowledge needed (JavaScript, CSS, HTML) is almost zero.

    +
    • +
  • +

    R has a huge community.

    +

    Many R users just ask questions on websites like StackOverflow.com, the largest online community for programmers. At the time of writing, 460,146 R-related questions have already been asked on this platform (that covers questions and answers for any programming language). In my own experience, most questions are answered within a couple of minutes.

    +
    • +
  • +

    R understands any data type, including SPSS/SAS/Stata.

    +

    And that’s not vice versa I’m afraid. You can import data from any source into R. For example from SPSS, SAS and Stata (link), from Minitab, Epi Info and EpiData (link), from Excel (link), from flat files like CSV, TXT or TSV (link), or directly from databases and datawarehouses from anywhere on the world (link). You can even scrape websites to download tables that are live on the internet (link) or get the results of an API call and transform it into data in only one command (link).

    +

    And the best part - you can export from R to most data formats as well. So you can import an SPSS file, do your analysis neatly in R and export the resulting tables to Excel files for sharing.

    +
    • +
  • +

    R is completely free and open-source.

    +

    No strings attached. It was created and is being maintained by volunteers who believe that (data) science should be open and publicly available to everybody. SPSS, SAS and Stata are quite expensive. IBM SPSS Staticstics only comes with subscriptions nowadays, varying between USD 1,300 and USD 8,500 per user per year. SAS Analytics Pro costs around USD 10,000 per computer. Stata also has a business model with subscription fees, varying between USD 600 and USD 2,800 per computer per year, but lower prices come with a limitation of the number of variables you can work with. And still they do not offer the above benefits of R.

    +

    If you are working at a midsized or small company, you can save it tens of thousands of dollars by using R instead of e.g. SPSS - gaining even more functions and flexibility. And all R enthousiasts can do as much PR as they want (like I do here), because nobody is officially associated with or affiliated by R. It is really free.

    +
    • +
  • +

    R is (nowadays) the preferred analysis software in academic papers.

    +

    At present, R is among the world most powerful statistical languages, and it is generally very popular in science (Bollmann et al., 2017). For all the above reasons, the number of references to R as an analysis method in academic papers is rising continuously and has even surpassed SPSS for academic use (Muenchen, 2014).

    +

    I believe that the thing with SPSS is, that it has always had a great user interface which is very easy to learn and use. Back when they developed it, they had very little competition, let alone from R. R didn’t even had a professional user interface until the last decade (called RStudio, see below). How people used R between the nineties and 2010 is almost completely incomparable to how R is being used now. The language itself has been restyled completely by volunteers who are dedicated professionals in the field of data science. SPSS was great when there was nothing else that could compete. But now in 2022, I don’t see any reason why SPSS would be of any better use than R.

    +
    • +
+

To demonstrate the first point:

+
+# not all values are valid MIC values:
+as.mic(0.125)
+# Class <mic>
+# [1] 0.125
+as.mic("testvalue")
+# Class <mic>
+# [1] <NA>
+
+# the Gram stain is available for all bacteria:
+mo_gramstain("E. coli")
+# [1] "Gram-negative"
+
+# Klebsiella is intrinsic resistant to amoxicillin, according to EUCAST:
+klebsiella_test <- data.frame(mo = "klebsiella", 
+                              amox = "S",
+                              stringsAsFactors = FALSE)
+klebsiella_test # (our original data)
+#           mo amox
+# 1 klebsiella    S
+eucast_rules(klebsiella_test, info = FALSE) # (the edited data by EUCAST rules)
+#           mo amox
+# 1 klebsiella    R
+
+# hundreds of trade names can be translated to a name, trade name or an ATC code:
+ab_name("floxapen")
+# [1] "Flucloxacillin"
+ab_tradenames("floxapen")
+# [1] "floxacillin"          "floxapen"             "floxapen sodium salt"
+# [4] "fluclox"              "flucloxacilina"       "flucloxacillin"      
+# [7] "flucloxacilline"      "flucloxacillinum"     "fluorochloroxacillin"
+ab_atc("floxapen")
+# [1] "J01CF05"
+
+
+

Import data from SPSS/SAS/Stata +

+
+

RStudio +

+

To work with R, probably the best option is to use RStudio. It is an open-source and free desktop environment which not only allows you to run R code, but also supports project management, version management, package management and convenient import menus to work with other data sources. You can also install RStudio Server on a private or corporate server, which brings nothing less than the complete RStudio software to you as a website (at home or at work).

+

To import a data file, just click Import Dataset in the Environment tab:

+

+

If additional packages are needed, RStudio will ask you if they should be installed on beforehand.

+

In the the window that opens, you can define all options (parameters) that should be used for import and you’re ready to go:

+

+

If you want named variables to be imported as factors so it resembles SPSS more, use as_factor().

+

The difference is this:

+
+SPSS_data
+# # A tibble: 4,203 x 4
+#     v001 sex       status    statusage
+#    <dbl> <dbl+lbl> <dbl+lbl>     <dbl>
+#  1 10002 1         1              76.6
+#  2 10004 0         1              59.1
+#  3 10005 1         1              54.5
+#  4 10006 1         1              54.1
+#  5 10007 1         1              57.7
+#  6 10008 1         1              62.8
+#  7 10010 0         1              63.7
+#  8 10011 1         1              73.1
+#  9 10017 1         1              56.7
+# 10 10018 0         1              66.6
+# # ... with 4,193 more rows
+
+as_factor(SPSS_data)
+# # A tibble: 4,203 x 4
+#     v001 sex    status statusage
+#    <dbl> <fct>  <fct>      <dbl>
+#  1 10002 Male   alive       76.6
+#  2 10004 Female alive       59.1
+#  3 10005 Male   alive       54.5
+#  4 10006 Male   alive       54.1
+#  5 10007 Male   alive       57.7
+#  6 10008 Male   alive       62.8
+#  7 10010 Female alive       63.7
+#  8 10011 Male   alive       73.1
+#  9 10017 Male   alive       56.7
+# 10 10018 Female alive       66.6
+# # ... with 4,193 more rows
+
+
+

Base R +

+

To import data from SPSS, SAS or Stata, you can use the great haven package yourself:

+
+# download and install the latest version:
+install.packages("haven")
+# load the package you just installed:
+library(haven)
+

You can now import files as follows:

+
+

SPSS +

+

To read files from SPSS into R:

+
+# read any SPSS file based on file extension (best way):
+read_spss(file = "path/to/file")
+
+# read .sav or .zsav file:
+read_sav(file = "path/to/file")
+
+# read .por file:
+read_por(file = "path/to/file")
+

Do not forget about as_factor(), as mentioned above.

+

To export your R objects to the SPSS file format:

+
+# save as .sav file:
+write_sav(data = yourdata, path = "path/to/file")
+
+# save as compressed .zsav file:
+write_sav(data = yourdata, path = "path/to/file", compress = TRUE)
+
+
+

SAS +

+

To read files from SAS into R:

+
+# read .sas7bdat + .sas7bcat files:
+read_sas(data_file = "path/to/file", catalog_file = NULL)
+
+# read SAS transport files (version 5 and version 8):
+read_xpt(file = "path/to/file")
+

To export your R objects to the SAS file format:

+
+# save as regular SAS file:
+write_sas(data = yourdata, path = "path/to/file")
+
+# the SAS transport format is an open format 
+# (required for submission of the data to the FDA)
+write_xpt(data = yourdata, path = "path/to/file", version = 8)
+
+
+

Stata +

+

To read files from Stata into R:

+
+# read .dta file:
+read_stata(file = "/path/to/file")
+
+# works exactly the same:
+read_dta(file = "/path/to/file")
+

To export your R objects to the Stata file format:

+
+# save as .dta file, Stata version 14:
+# (supports Stata v8 until v15 at the time of writing)
+write_dta(data = yourdata, path = "/path/to/file", version = 14)
+
+
+
+
+
+ + + + +
+ + + + + + + diff --git a/articles/WHONET.html b/articles/WHONET.html new file mode 100644 index 00000000..45cdcc40 --- /dev/null +++ b/articles/WHONET.html @@ -0,0 +1,398 @@ + + + + + + + + +How to work with WHONET data • AMR (for R) + + + + + + + + + + + + + + + + + + + + + + Skip to contents + + +
+ + + + +
+
+

How to work with WHONET data

+ + + Source: vignettes/WHONET.Rmd +
WHONET.Rmd
+
+ + + +
+

Import of data +

+

This tutorial assumes you already imported the WHONET data with e.g. the readxl package. In RStudio, this can be done using the menu button ‘Import Dataset’ in the tab ‘Environment’. Choose the option ‘From Excel’ and select your exported file. Make sure date fields are imported correctly.

+

An example syntax could look like this:

+
+library(readxl)
+data <- read_excel(path = "path/to/your/file.xlsx")
+

This package comes with an example data set WHONET. We will use it for this analysis.

+
+
+

Preparation +

+

First, load the relevant packages if you did not yet did this. I use the tidyverse for all of my analyses. All of them. If you don’t know it yet, I suggest you read about it on their website: https://www.tidyverse.org/.

+
+library(dplyr)   # part of tidyverse
+library(ggplot2) # part of tidyverse
+library(AMR)     # this package
+library(cleaner) # to create frequency tables
+

We will have to transform some variables to simplify and automate the analysis:

+
    +
  • Microorganisms should be transformed to our own microorganism codes (called an mo) using our Catalogue of Life reference data set, which contains all ~70,000 microorganisms from the taxonomic kingdoms Bacteria, Fungi and Protozoa. We do the tranformation with as.mo(). This function also recognises almost all WHONET abbreviations of microorganisms.
    • +
  • Antimicrobial results or interpretations have to be clean and valid. In other words, they should only contain values "S", "I" or "R". That is exactly where the as.rsi() function is for.
    • +
+
+# transform variables
+data <- WHONET %>%
+  # get microbial ID based on given organism
+  mutate(mo = as.mo(Organism)) %>% 
+  # transform everything from "AMP_ND10" to "CIP_EE" to the new `rsi` class
+  mutate_at(vars(AMP_ND10:CIP_EE), as.rsi)
+

No errors or warnings, so all values are transformed succesfully.

+

We also created a package dedicated to data cleaning and checking, called the cleaner package. Its freq() function can be used to create frequency tables.

+

So let’s check our data, with a couple of frequency tables:

+
+# our newly created `mo` variable, put in the mo_name() function
+data %>% freq(mo_name(mo), nmax = 10)
+

Frequency table

+

Class: character
+Length: 500
+Available: 500 (100.0%, NA: 0 = 0.0%)
+Unique: 37

+

Shortest: 11
+Longest: 40

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
ItemCountPercentCum. CountCum. Percent
1Escherichia coli24549.0%24549.0%
2Coagulase-negative Staphylococcus (CoNS)7414.8%31963.8%
3Staphylococcus epidermidis387.6%35771.4%
4Streptococcus pneumoniae316.2%38877.6%
5Staphylococcus hominis214.2%40981.8%
6Proteus mirabilis91.8%41883.6%
7Enterococcus faecium81.6%42685.2%
8Staphylococcus capitis81.6%43486.8%
9Enterobacter cloacae51.0%43987.8%
10Streptococcus anginosus51.0%44488.8%
+

(omitted 27 entries, n = 56 [11.20%])

+
+# our transformed antibiotic columns
+# amoxicillin/clavulanic acid (J01CR02) as an example
+data %>% freq(AMC_ND2)
+

Frequency table

+

Class: factor > ordered > rsi (numeric)
+Length: 500
+Levels: 3: S < I < R
+Available: 481 (96.2%, NA: 19 = 3.8%)
+Unique: 3

+

Drug: Amoxicillin/clavulanic acid (AMC, J01CR02)
+Drug group: Beta-lactams/penicillins
+%SI: 78.59%

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
ItemCountPercentCum. CountCum. Percent
1S35674.01%35674.01%
2R10321.41%45995.43%
3I224.57%481100.00%
+
+
+

A first glimpse at results +

+

An easy ggplot will already give a lot of information, using the included ggplot_rsi() function:

+
+data %>%
+  group_by(Country) %>%
+  select(Country, AMP_ND2, AMC_ED20, CAZ_ED10, CIP_ED5) %>%
+  ggplot_rsi(translate_ab = 'ab', facet = "Country", datalabels = FALSE)
+

+
+
+
+ + + + +
+ + + + + + + diff --git a/articles/WHONET_files/figure-html/unnamed-chunk-7-1.png b/articles/WHONET_files/figure-html/unnamed-chunk-7-1.png new file mode 100644 index 00000000..cb1280db Binary files /dev/null and b/articles/WHONET_files/figure-html/unnamed-chunk-7-1.png differ diff --git a/articles/datasets.html b/articles/datasets.html new file mode 100644 index 00000000..366b416a --- /dev/null +++ b/articles/datasets.html @@ -0,0 +1,1320 @@ + + + + + + + + +Data sets for download / own use • AMR (for R) + + + + + + + + + + + + + + + + + + + + + + Skip to contents + + +
+ + + + +
+
+

Data sets for download / own use

+ +

21 August 2022

+ + Source: vignettes/datasets.Rmd +
datasets.Rmd
+
+ + + +

All reference data (about microorganisms, antibiotics, R/SI interpretation, EUCAST rules, etc.) in this AMR package are reliable, up-to-date and freely available. We continually export our data sets to formats for use in R, SPSS, SAS, Stata and Excel. We also supply tab separated files that are machine-readable and suitable for input in any software program, such as laboratory information systems.

+

On this page, we explain how to download them and how the structure of the data sets look like.

+

+If you are reading this page from within R, please visit our website, which is automatically updated with every code change. +

+
+

Microorganisms (currently accepted names) +

+

A data set with 70,764 rows and 16 columns, containing the following column names:
mo, fullname, kingdom, phylum, class, order, family, genus, species, subspecies, rank, ref, species_id, source, prevalence and snomed.

+

This data set is in R available as microorganisms, after you load the AMR package.

+

It was last updated on 21 August 2022 14:52:57 UTC. Find more info about the structure of this data set here.

+

Direct download links:

+ +

NOTE: The exported files for SAS, SPSS and Stata do not contain SNOMED codes, as their file size would exceed 100 MB; the file size limit of GitHub. Advice? Use R instead.

+
+

Source +

+

Our full taxonomy of microorganisms is based on the authoritative and comprehensive:

+ +
+
+

Example content +

+

Included (sub)species per taxonomic kingdom:

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
KingdomNumber of (sub)species
(unknown kingdom)5
Animalia2,153
Archaea694
Bacteria22,852
Chromista32,167
Fungi9,582
+

Example rows when filtering on genus Escherichia:

+ ++++++++++++++++++ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
mofullnamekingdomphylumclassorderfamilygenusspeciessubspeciesrankrefspecies_idsourceprevalencesnomed
B_ESCHREscherichiaBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichiagenus515602LPSN164735005
B_ESCHR_ALBREscherichia albertiiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichiaalbertiispeciesHuys et al., 2003776053LPSN1419388003
B_ESCHR_COLIEscherichia coliBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichiacolispeciesCastellani et al., 1919776057LPSN11095001000112106, 715307006, 737528008, …
B_ESCHR_FRGSEscherichia fergusoniiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichiafergusoniispeciesFarmer et al., 1985776059LPSN172461005
B_ESCHR_HRMNEscherichia hermanniiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichiahermanniispeciesBrenner et al., 1983776060LPSN185786000
B_ESCHR_MRMTEscherichia marmotaeBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichiamarmotaespeciesLiu et al., 2015792928LPSN114961000146107
+
+
+
+

Microorganisms (previously accepted names) +

+

A data set with 14,338 rows and 4 columns, containing the following column names:
fullname, fullname_new, ref and prevalence.

+

Note: remember that the ‘ref’ columns contains the scientific reference to the old taxonomic entries, i.e. of column ‘fullname’. For the scientific reference of the new names, i.e. of column ‘fullname_new’, see the microorganisms data set.

+

This data set is in R available as microorganisms.old, after you load the AMR package.

+

It was last updated on 21 August 2022 14:52:57 UTC. Find more info about the structure of this data set here.

+

Direct download links:

+ +
+

Source +

+

This data set contains old, previously accepted taxonomic names. The data sources are the same as the microorganisms data set:

+ +
+
+

Example content +

+

Example rows when filtering on Escherichia:

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +
fullnamefullname_newrefprevalence
Escherichia adecarboxylataLeclercia adecarboxylataLeclerc, 19621
Escherichia blattaeShimwellia blattaeBurgess et al., 19731
Escherichia vulnerisPseudescherichia vulnerisBrenner et al., 19831
+
+
+
+

Antibiotic agents +

+

A data set with 464 rows and 14 columns, containing the following column names:
ab, cid, name, group, atc, atc_group1, atc_group2, abbreviations, synonyms, oral_ddd, oral_units, iv_ddd, iv_units and loinc.

+

This data set is in R available as antibiotics, after you load the AMR package.

+

It was last updated on 21 August 2022 14:52:57 UTC. Find more info about the structure of this data set here.

+

Direct download links:

+ +
+

Source +

+

This data set contains all EARS-Net and ATC codes gathered from WHO and WHONET, and all compound IDs from PubChem. It also contains all brand names (synonyms) as found on PubChem and Defined Daily Doses (DDDs) for oral and parenteral administration.

+ +
+
+

Example content +

+ ++++++++++++++++ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
abcidnamegroupatcatc_group1atc_group2abbreviationssynonymsoral_dddoral_unitsiv_dddiv_unitsloinc
AMK37768AmikacinAminoglycosidesD06AX12, J01GB06, S01AA21Aminoglycoside antibacterialsOther aminoglycosidesak, ami, amik, …amicacin, amikacillin, amikacin, …1.0g13546-7, 15098-7, 17798-0, …
AMX33613AmoxicillinBeta-lactams/penicillinsJ01CA04Beta-lactam antibacterials, penicillinsPenicillins with extended spectrumac, amox, amxactimoxi, amoclen, amolin, …1.5g3.0g16365-9, 25274-2, 3344-9, …
AMC23665637Amoxicillin/clavulanic acidBeta-lactams/penicillinsJ01CR02Beta-lactam antibacterials, penicillinsCombinations of penicillins, incl. beta-lactamase inhibitorsa/c, amcl, aml, …amocla, amoclan, amoclav, …1.5g3.0g
AMP6249AmpicillinBeta-lactams/penicillinsJ01CA01, S01AA19Beta-lactam antibacterials, penicillinsPenicillins with extended spectrumam, amp, ampiacillin, adobacillin, amblosin, …2.0g6.0g21066-6, 3355-5, 33562-0, …
AZM447043AzithromycinMacrolides/lincosamidesJ01FA10, S01AA26Macrolides, lincosamides and streptograminsMacrolidesaz, azi, azit, …aritromicina, azasite, azenil, …0.3g0.5g16420-2, 25233-8
PEN5904BenzylpenicillinBeta-lactams/penicillinsJ01CE01, S01AA14Combinations of antibacterialsCombinations of antibacterialsbepe, pen, peni, …abbocillin, ayercillin, bencilpenicilina, …3.6g3913-1
+
+
+
+

Antiviral agents +

+

A data set with 102 rows and 9 columns, containing the following column names:
atc, cid, name, atc_group, synonyms, oral_ddd, oral_units, iv_ddd and iv_units.

+

This data set is in R available as antivirals, after you load the AMR package.

+

It was last updated on 21 August 2022 14:52:57 UTC. Find more info about the structure of this data set here.

+

Direct download links:

+ +
+

Source +

+

This data set contains all ATC codes gathered from WHO and all compound IDs from PubChem. It also contains all brand names (synonyms) as found on PubChem and Defined Daily Doses (DDDs) for oral and parenteral administration.

+ +
+
+

Example content +

+ +++++++++++ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
atccidnameatc_groupsynonymsoral_dddoral_unitsiv_dddiv_units
J05AF06441300AbacavirNucleoside and nucleotide reverse transcriptase inhibitorsAbacavir, Abacavir sulfate, Ziagen0.6g
J05AB01135398513AciclovirNucleosides and nucleotides excl. reverse transcriptase inhibitorsAcicloftal, Aciclovier, Aciclovir, …4.0g4g
J05AF0860871Adefovir dipivoxilNucleoside and nucleotide reverse transcriptase inhibitorsAdefovir di ester, Adefovir dipivoxil, Adefovir Dipivoxil, …10.0mg
J05AE0565016AmprenavirProtease inhibitorsAgenerase, Amprenavir, Amprenavirum, …1.2g
J05AP0616076883AsunaprevirAntivirals for treatment of HCV infectionsAsunaprevir, Sunvepra
J05AE08148192AtazanavirProtease inhibitorsAtazanavir, Atazanavir Base, Latazanavir, …0.3g
+
+
+
+

Interpretation from MIC values / disk diameters to R/SI +

+

A data set with 20,369 rows and 11 columns, containing the following column names:
guideline, method, site, mo, rank_index, ab, ref_tbl, disk_dose, breakpoint_S, breakpoint_R and uti.

+

This data set is in R available as rsi_translation, after you load the AMR package.

+

It was last updated on 21 August 2022 14:52:57 UTC. Find more info about the structure of this data set here.

+

Direct download links:

+ +
+

Source +

+

This data set contains interpretation rules for MIC values and disk diffusion diameters. Included guidelines are CLSI (2011-2022) and EUCAST (2011-2022).

+
+
+

Example content +

+ +++++++++++++++ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
guidelinemethodsitemomo_namerank_indexabab_nameref_tbldisk_dosebreakpoint_Sbreakpoint_Ruti
EUCAST 2022MICF_ASPRG_MGTSAspergillus fumigatus2AMBAmphotericin BAspergillus11FALSE
EUCAST 2022MICF_ASPRG_NIGRAspergillus niger2AMBAmphotericin BAspergillus11FALSE
EUCAST 2022MICF_CANDDCandida3AMBAmphotericin BCandida11FALSE
EUCAST 2022MICF_CANDD_ALBCCandida albicans2AMBAmphotericin BCandida11FALSE
EUCAST 2022MICF_CANDD_DBLNCandida dubliniensis2AMBAmphotericin BCandida11FALSE
EUCAST 2022MICF_CANDD_KRUSCandida krusei2AMBAmphotericin BCandida11FALSE
+
+
+
+

Intrinsic bacterial resistance +

+

A data set with 134,956 rows and 2 columns, containing the following column names:
mo and ab.

+

This data set is in R available as intrinsic_resistant, after you load the AMR package.

+

It was last updated on 21 August 2022 14:52:57 UTC. Find more info about the structure of this data set here.

+

Direct download links:

+ +
+

Source +

+

This data set contains all defined intrinsic resistance by EUCAST of all bug-drug combinations, and is based on ‘EUCAST Expert Rules’ and ‘EUCAST Intrinsic Resistance and Unusual Phenotypes’ v3.3 (2021).

+
+
+

Example content +

+

Example rows when filtering on Enterobacter cloacae:

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
microorganismantibiotic
Enterobacter cloacaeAcetylmidecamycin
Enterobacter cloacaeAcetylspiramycin
Enterobacter cloacaeAmoxicillin
Enterobacter cloacaeAmoxicillin/clavulanic acid
Enterobacter cloacaeAmpicillin
Enterobacter cloacaeAmpicillin/sulbactam
Enterobacter cloacaeAvoparcin
Enterobacter cloacaeAzithromycin
Enterobacter cloacaeBenzylpenicillin
Enterobacter cloacaeCadazolid
Enterobacter cloacaeCefadroxil
Enterobacter cloacaeCefazolin
Enterobacter cloacaeCefoxitin
Enterobacter cloacaeCephalexin
Enterobacter cloacaeCephalothin
Enterobacter cloacaeClarithromycin
Enterobacter cloacaeClindamycin
Enterobacter cloacaeCycloserine
Enterobacter cloacaeDalbavancin
Enterobacter cloacaeDirithromycin
Enterobacter cloacaeErythromycin
Enterobacter cloacaeFlurithromycin
Enterobacter cloacaeFusidic acid
Enterobacter cloacaeGamithromycin
Enterobacter cloacaeJosamycin
Enterobacter cloacaeKitasamycin
Enterobacter cloacaeLincomycin
Enterobacter cloacaeLinezolid
Enterobacter cloacaeMeleumycin
Enterobacter cloacaeMidecamycin
Enterobacter cloacaeMiocamycin
Enterobacter cloacaeNafithromycin
Enterobacter cloacaeNorvancomycin
Enterobacter cloacaeOleandomycin
Enterobacter cloacaeOritavancin
Enterobacter cloacaePirlimycin
Enterobacter cloacaePrimycin
Enterobacter cloacaePristinamycin
Enterobacter cloacaeQuinupristin/dalfopristin
Enterobacter cloacaeRamoplanin
Enterobacter cloacaeRifampicin
Enterobacter cloacaeRokitamycin
Enterobacter cloacaeRoxithromycin
Enterobacter cloacaeSolithromycin
Enterobacter cloacaeSpiramycin
Enterobacter cloacaeTedizolid
Enterobacter cloacaeTeicoplanin
Enterobacter cloacaeTelavancin
Enterobacter cloacaeTelithromycin
Enterobacter cloacaeThiacetazone
Enterobacter cloacaeTildipirosin
Enterobacter cloacaeTilmicosin
Enterobacter cloacaeTroleandomycin
Enterobacter cloacaeTulathromycin
Enterobacter cloacaeTylosin
Enterobacter cloacaeTylvalosin
Enterobacter cloacaeVancomycin
+
+
+
+

Dosage guidelines from EUCAST +

+

A data set with 169 rows and 9 columns, containing the following column names:
ab, name, type, dose, dose_times, administration, notes, original_txt and eucast_version.

+

This data set is in R available as dosage, after you load the AMR package.

+

It was last updated on 21 August 2022 14:52:57 UTC. Find more info about the structure of this data set here.

+

Direct download links:

+ +
+

Source +

+

EUCAST breakpoints used in this package are based on the dosages in this data set.

+

Currently included dosages in the data set are meant for: ‘EUCAST Clinical Breakpoint Tables’ v11.0 (2021).

+
+
+

Example content +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
abnametypedosedose_timesadministrationnotesoriginal_txteucast_version
AMKAmikacinstandard_dosage25-30 mg/kg1iv25-30 mg/kg x 1 iv11
AMXAmoxicillinhigh_dosage2 g6iv2 g x 6 iv11
AMXAmoxicillinstandard_dosage1 g3iv1 g x 3-4 iv11
AMXAmoxicillinhigh_dosage0.75-1 g3oral0.75-1 g x 3 oral11
AMXAmoxicillinstandard_dosage0.5 g3oral0.5 g x 3 oral11
AMXAmoxicillinuncomplicated_uti0.5 g3oral0.5 g x 3 oral11
+
+
+
+
+ + + + +
+ + + + + + + diff --git a/articles/index.html b/articles/index.html new file mode 100644 index 00000000..fead896b --- /dev/null +++ b/articles/index.html @@ -0,0 +1,174 @@ + +Articles • AMR (for R) + Skip to contents + + +
+
+
+

Articles

+
+ +
+

All vignettes

+

+ +
How to conduct AMR data analysis
+
+
How to apply EUCAST rules
+
+
How to determine multi-drug resistance (MDR)
+
+
How to conduct principal component analysis (PCA) for AMR
+
+
How to import data from SPSS / SAS / Stata
+
+
How to work with WHONET data
+
+
Data sets for download / own use
+
+
How to predict antimicrobial resistance
+
+
Welcome to the `AMR` package
+
+
+
+ + +
+ + + + + + + diff --git a/articles/resistance_predict.html b/articles/resistance_predict.html new file mode 100644 index 00000000..b0443783 --- /dev/null +++ b/articles/resistance_predict.html @@ -0,0 +1,354 @@ + + + + + + + + +How to predict antimicrobial resistance • AMR (for R) + + + + + + + + + + + + + + + + + + + + + + Skip to contents + + +
+ + + + +
+
+

How to predict antimicrobial resistance

+ + + Source: vignettes/resistance_predict.Rmd +
resistance_predict.Rmd
+
+ + + +
+

Needed R packages +

+

As with many uses in R, we need some additional packages for AMR data analysis. Our package works closely together with the tidyverse packages dplyr and ggplot2 by Dr Hadley Wickham. The tidyverse tremendously improves the way we conduct data science - it allows for a very natural way of writing syntaxes and creating beautiful plots in R.

+

Our AMR package depends on these packages and even extends their use and functions.

+
+library(dplyr)
+library(ggplot2)
+library(AMR)
+
+# (if not yet installed, install with:)
+# install.packages(c("tidyverse", "AMR"))
+
+
+

Prediction analysis +

+

Our package contains a function resistance_predict(), which takes the same input as functions for other AMR data analysis. Based on a date column, it calculates cases per year and uses a regression model to predict antimicrobial resistance.

+

It is basically as easy as:

+
# resistance prediction of piperacillin/tazobactam (TZP):
+resistance_predict(tbl = example_isolates, col_date = "date", col_ab = "TZP", model = "binomial")
+
+# or:
+example_isolates %>% 
+  resistance_predict(col_ab = "TZP",
+                     model  "binomial")
+
+# to bind it to object 'predict_TZP' for example:
+predict_TZP <- example_isolates %>% 
+  resistance_predict(col_ab = "TZP",
+                     model = "binomial")
+

The function will look for a date column itself if col_date is not set.

+

When running any of these commands, a summary of the regression model will be printed unless using resistance_predict(..., info = FALSE).

+
# ℹ Using column 'date' as input for `col_date`.
+

This text is only a printed summary - the actual result (output) of the function is a data.frame containing for each year: the number of observations, the actual observed resistance, the estimated resistance and the standard error below and above the estimation:

+
+predict_TZP
+#    year      value    se_min    se_max observations   observed  estimated
+# 1  2002 0.20000000        NA        NA           15 0.20000000 0.05616378
+# 2  2003 0.06250000        NA        NA           32 0.06250000 0.06163839
+# 3  2004 0.08536585        NA        NA           82 0.08536585 0.06760841
+# 4  2005 0.05000000        NA        NA           60 0.05000000 0.07411100
+# 5  2006 0.05084746        NA        NA           59 0.05084746 0.08118454
+# 6  2007 0.12121212        NA        NA           66 0.12121212 0.08886843
+# 7  2008 0.04166667        NA        NA           72 0.04166667 0.09720264
+# 8  2009 0.01639344        NA        NA           61 0.01639344 0.10622731
+# 9  2010 0.05660377        NA        NA           53 0.05660377 0.11598223
+# 10 2011 0.18279570        NA        NA           93 0.18279570 0.12650615
+# 11 2012 0.30769231        NA        NA           65 0.30769231 0.13783610
+# 12 2013 0.06896552        NA        NA           58 0.06896552 0.15000651
+# 13 2014 0.10000000        NA        NA           60 0.10000000 0.16304829
+# 14 2015 0.23636364        NA        NA           55 0.23636364 0.17698785
+# 15 2016 0.22619048        NA        NA           84 0.22619048 0.19184597
+# 16 2017 0.16279070        NA        NA           86 0.16279070 0.20763675
+# 17 2018 0.22436641 0.1938710 0.2548618           NA         NA 0.22436641
+# 18 2019 0.24203228 0.2062911 0.2777735           NA         NA 0.24203228
+# 19 2020 0.26062172 0.2191758 0.3020676           NA         NA 0.26062172
+# 20 2021 0.28011130 0.2325557 0.3276669           NA         NA 0.28011130
+# 21 2022 0.30046606 0.2464567 0.3544755           NA         NA 0.30046606
+# 22 2023 0.32163907 0.2609011 0.3823771           NA         NA 0.32163907
+# 23 2024 0.34357130 0.2759081 0.4112345           NA         NA 0.34357130
+# 24 2025 0.36619175 0.2914934 0.4408901           NA         NA 0.36619175
+# 25 2026 0.38941799 0.3076686 0.4711674           NA         NA 0.38941799
+# 26 2027 0.41315710 0.3244399 0.5018743           NA         NA 0.41315710
+# 27 2028 0.43730688 0.3418075 0.5328063           NA         NA 0.43730688
+# 28 2029 0.46175755 0.3597639 0.5637512           NA         NA 0.46175755
+# 29 2030 0.48639359 0.3782932 0.5944939           NA         NA 0.48639359
+# 30 2031 0.51109592 0.3973697 0.6248221           NA         NA 0.51109592
+# 31 2032 0.53574417 0.4169574 0.6545309           NA         NA 0.53574417
+

The function plot is available in base R, and can be extended by other packages to depend the output based on the type of input. We extended its function to cope with resistance predictions:

+
+plot(predict_TZP)
+

+

This is the fastest way to plot the result. It automatically adds the right axes, error bars, titles, number of available observations and type of model.

+

We also support the ggplot2 package with our custom function ggplot_rsi_predict() to create more appealing plots:

+
+ggplot_rsi_predict(predict_TZP)
+

+
+
+# choose for error bars instead of a ribbon
+ggplot_rsi_predict(predict_TZP, ribbon = FALSE)
+

+
+

Choosing the right model +

+

Resistance is not easily predicted; if we look at vancomycin resistance in Gram-positive bacteria, the spread (i.e. standard error) is enormous:

+
+example_isolates %>%
+  filter(mo_gramstain(mo, language = NULL) == "Gram-positive") %>%
+  resistance_predict(col_ab = "VAN", year_min = 2010, info = FALSE, model = "binomial") %>% 
+  ggplot_rsi_predict()
+# ℹ Using column 'date' as input for `col_date`.
+

+

Vancomycin resistance could be 100% in ten years, but might remain very low.

+

You can define the model with the model parameter. The model chosen above is a generalised linear regression model using a binomial distribution, assuming that a period of zero resistance was followed by a period of increasing resistance leading slowly to more and more resistance.

+

Valid values are:

+ +++++ + + + + + + + + + + + + + + + + + + + + + + +
Input valuesFunction used by RType of model
+"binomial" or "binom" or "logit" +glm(..., family = binomial)Generalised linear model with binomial distribution
+"loglin" or "poisson" +glm(..., family = poisson)Generalised linear model with poisson distribution
+"lin" or "linear" +lm()Linear model
+

For the vancomycin resistance in Gram-positive bacteria, a linear model might be more appropriate:

+
+example_isolates %>%
+  filter(mo_gramstain(mo, language = NULL) == "Gram-positive") %>%
+  resistance_predict(col_ab = "VAN", year_min = 2010, info = FALSE, model = "linear") %>% 
+  ggplot_rsi_predict()
+# ℹ Using column 'date' as input for `col_date`.
+

+

The model itself is also available from the object, as an attribute:

+
+model <- attributes(predict_TZP)$model
+
+summary(model)$family
+# 
+# Family: binomial 
+# Link function: logit
+
+summary(model)$coefficients
+#                  Estimate  Std. Error   z value     Pr(>|z|)
+# (Intercept) -200.67944891 46.17315349 -4.346237 1.384932e-05
+# year           0.09883005  0.02295317  4.305725 1.664395e-05
+
+
+
+
+ + + + +
+ + + + + + + diff --git a/articles/resistance_predict_files/figure-html/unnamed-chunk-4-1.png b/articles/resistance_predict_files/figure-html/unnamed-chunk-4-1.png new file mode 100644 index 00000000..b65784ad Binary files /dev/null and b/articles/resistance_predict_files/figure-html/unnamed-chunk-4-1.png differ diff --git a/articles/resistance_predict_files/figure-html/unnamed-chunk-5-1.png b/articles/resistance_predict_files/figure-html/unnamed-chunk-5-1.png new file mode 100644 index 00000000..a419c10d Binary files /dev/null and b/articles/resistance_predict_files/figure-html/unnamed-chunk-5-1.png differ diff --git a/articles/resistance_predict_files/figure-html/unnamed-chunk-5-2.png b/articles/resistance_predict_files/figure-html/unnamed-chunk-5-2.png new file mode 100644 index 00000000..17da220b Binary files /dev/null and b/articles/resistance_predict_files/figure-html/unnamed-chunk-5-2.png differ diff --git a/articles/resistance_predict_files/figure-html/unnamed-chunk-6-1.png b/articles/resistance_predict_files/figure-html/unnamed-chunk-6-1.png new file mode 100644 index 00000000..c0fea349 Binary files /dev/null and b/articles/resistance_predict_files/figure-html/unnamed-chunk-6-1.png differ diff --git a/articles/resistance_predict_files/figure-html/unnamed-chunk-7-1.png b/articles/resistance_predict_files/figure-html/unnamed-chunk-7-1.png new file mode 100644 index 00000000..01b47606 Binary files /dev/null and b/articles/resistance_predict_files/figure-html/unnamed-chunk-7-1.png differ diff --git a/articles/welcome_to_AMR.html b/articles/welcome_to_AMR.html new file mode 100644 index 00000000..35be9864 --- /dev/null +++ b/articles/welcome_to_AMR.html @@ -0,0 +1,226 @@ + + + + + + + + +Welcome to the `AMR` package • AMR (for R) + + + + + + + + + + + + + + + + + + + + + + Skip to contents + + +
+ + + + +
+
+

Welcome to the `AMR` package

+ + + Source: vignettes/welcome_to_AMR.Rmd +
welcome_to_AMR.Rmd
+
+ + + +

Note: to keep the package size as small as possible, we only included this vignette on CRAN. You can read more vignettes on our website about how to conduct AMR data analysis, determine MDRO’s, find explanation of EUCAST rules, and much more: https://msberends.github.io/AMR/articles/.

+
+

AMR is a free, open-source and independent R package (see Copyright) to simplify the analysis and prediction of Antimicrobial Resistance (AMR) and to work with microbial and antimicrobial data and properties, by using evidence-based methods. Our aim is to provide a standard for clean and reproducible antimicrobial resistance data analysis, that can therefore empower epidemiological analyses to continuously enable surveillance and treatment evaluation in any setting.

+

After installing this package, R knows ~71,000 distinct microbial species and all ~570 antibiotic, antimycotic and antiviral drugs by name and code (including ATC, EARS-Net, PubChem, LOINC and SNOMED CT), and knows all about valid R/SI and MIC values. It supports any data format, including WHONET/EARS-Net data.

+

The AMR package is available in Danish, Dutch, English, French, German, Italian, Portuguese, Russian, Spanish and Swedish. Antimicrobial drug (group) names and colloquial microorganism names are provided in these languages.

+

This package is fully independent of any other R package and works on Windows, macOS and Linux with all versions of R since R-3.0 (April 2013). It was designed to work in any setting, including those with very limited resources. Since its first public release in early 2018, this package has been downloaded from more than 175 countries.

+

This package can be used for:

+
    +
  • Reference for the taxonomy of microorganisms, since the package contains all microbial (sub)species from the Catalogue of Life and List of Prokaryotic names with Standing in Nomenclature
    • +
  • Interpreting raw MIC and disk diffusion values, based on the latest CLSI or EUCAST guidelines
    • +
  • Retrieving antimicrobial drug names, doses and forms of administration from clinical health care records
    • +
  • Determining first isolates to be used for AMR data analysis
    • +
  • Calculating antimicrobial resistance
    • +
  • Determining multi-drug resistance (MDR) / multi-drug resistant organisms (MDRO)
    • +
  • Calculating (empirical) susceptibility of both mono therapy and combination therapies
    • +
  • Predicting future antimicrobial resistance using regression models
    • +
  • Getting properties for any microorganism (like Gram stain, species, genus or family)
    • +
  • Getting properties for any antibiotic (like name, code of EARS-Net/ATC/LOINC/PubChem, defined daily dose or trade name)
    • +
  • Plotting antimicrobial resistance
    • +
  • Applying EUCAST expert rules
    • +
  • Getting SNOMED codes of a microorganism, or getting properties of a microorganism based on a SNOMED code
    • +
  • Getting LOINC codes of an antibiotic, or getting properties of an antibiotic based on a LOINC code
    • +
  • Machine reading the EUCAST and CLSI guidelines from 2011-2020 to translate MIC values and disk diffusion diameters to R/SI
    • +
  • Principal component analysis for AMR
    • +
+

All reference data sets (about microorganisms, antibiotics, R/SI interpretation, EUCAST rules, etc.) in this AMR package are publicly and freely available. We continually export our data sets to formats for use in R, SPSS, SAS, Stata and Excel. We also supply flat files that are machine-readable and suitable for input in any software program, such as laboratory information systems. Please find all download links on our website, which is automatically updated with every code change.

+

This R package was created for both routine data analysis and academic research at the Faculty of Medical Sciences of the University of Groningen, in collaboration with non-profit organisations Certe Medical Diagnostics and Advice Foundation and University Medical Center Groningen. This R package formed the basis of two PhD theses (DOI 10.33612/diss.177417131 and DOI 10.33612/diss.192486375) but is actively and durably maintained (see changelog)) by two public healthcare organisations in the Netherlands.

+
+
+ + + + +
+ + + + + + + diff --git a/authors.html b/authors.html new file mode 100644 index 00000000..3a65d6b6 --- /dev/null +++ b/authors.html @@ -0,0 +1,265 @@ + +Authors and Citation • AMR (for R) + Skip to contents + + +
+
+
+

Authors and Citation

+
+ +
+

Authors

+ +
  • +

    Matthijs S. Berends. Author, maintainer. +

    +
    • +
  • +

    Christian F. Luz. Author, contributor. +

    +
    • +
  • +

    Dennis Souverein. Author, contributor. +

    +
    • +
  • +

    Erwin E. A. Hassing. Author, contributor. +

    +
    • +
  • +

    Casper Albers. Thesis advisor. +

    +
    • +
  • +

    Peter Dutey-Magni. Contributor. +

    +
    • +
  • +

    Judith Fonville. Contributor. +

    +
    • +
  • +

    Alex Friedrich. Thesis advisor. +

    +
    • +
  • +

    Corinna Glasner. Thesis advisor. +

    +
    • +
  • +

    Eric Hazenberg. Contributor. +

    +
    • +
  • +

    Gwen Knight. Contributor. +

    +
    • +
  • +

    Annick Lenglet. Contributor. +

    +
    • +
  • +

    Bart Meijer. Contributor. +

    +
    • +
  • +

    Anton Mymrikov. Contributor. +

    +
    • +
  • +

    Sofia Ny. Contributor. +

    +
    • +
  • +

    Rogier Schade. Contributor. +

    +
    • +
  • +

    Bhanu Sinha. Thesis advisor. +

    +
    • +
  • +

    Anthony Underwood. Contributor. +

    +
    • +
+ +
+

Citation

+

Source: inst/CITATION

+ +

Berends MS, Luz CF, Friedrich AW, Sinha BNM, Albers CJ, Glasner C (2021). AMR - An R Package for Working with +Antimicrobial Resistance Data. Journal of Statistical Software (accepted for publication), https://www.biorxiv.org/content/10.1101/810622, doi: 10.1101/810622.

+ 
@Article{,
+  title = {AMR - An R Package for Working with Antimicrobial Resistance Data},
+  author = {M S Berends and C F Luz and A W Friedrich and B N M Sinha and C J Albers and C Glasner},
+  doi = {10.1101/810622},
+  journal = {Journal of Statistical Software},
+  pages = {Accepted for publication},
+  year = {2021},
+  url = {https://www.biorxiv.org/content/10.1101/810622},
+}
+

Berends, MS (2021). A New Instrument for Microbial Epidemiology: Empowering Antimicrobial Resistance Data Analysis (PhD thesis). University of Groningen, doi: 10.33612/diss.177417131.

+ 
@PhdThesis{,
+  title = {A New Instrument for Microbial Epidemiology: Empowering Antimicrobial Resistance Data Analysis},
+  author = {M S Berends},
+  publisher = {University of Groningen},
+  school = {University of Groningen},
+  doi = {10.33612/diss.177417131},
+  pages = {287},
+  year = {2021},
+}
+

Luz, CF (2021). Data Science for Infection Management & Antimicrobial Stewardship (PhD thesis). University of Groningen, doi: 10.33612/diss.192486375.

+ 
@PhdThesis{,
+  title = {Data Science for Infection Management & Antimicrobial Stewardship},
+  author = {C F Luz},
+  publisher = {University of Groningen},
+  school = {University of Groningen},
+  doi = {10.33612/diss.192486375},
+  pages = {326},
+  year = {2021},
+}
+
+
+ + +
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document.documentElement&&[].concat(...document.body.children).forEach((t=>j.off(t,"mouseover",d))),this._popper&&this._popper.destroy(),this._menu.classList.remove(Je),this._element.classList.remove(Je),this._element.setAttribute("aria-expanded","false"),U.removeDataAttribute(this._menu,"popper"),j.trigger(this._element,"hidden.bs.dropdown",t))}_getConfig(t){if(t={...this.constructor.Default,...U.getDataAttributes(this._element),...t},a(Ue,t,this.constructor.DefaultType),"object"==typeof t.reference&&!o(t.reference)&&"function"!=typeof t.reference.getBoundingClientRect)throw new TypeError(`${Ue.toUpperCase()}: Option "reference" provided type "object" without a required "getBoundingClientRect" method.`);return t}_createPopper(t){if(void 0===Fe)throw new TypeError("Bootstrap's dropdowns require Popper (https://popper.js.org)");let e=this._element;"parent"===this._config.reference?e=t:o(this._config.reference)?e=r(this._config.reference):"object"==typeof this._config.reference&&(e=this._config.reference);const i=this._getPopperConfig(),n=i.modifiers.find((t=>"applyStyles"===t.name&&!1===t.enabled));this._popper=qe(e,this._menu,i),n&&U.setDataAttribute(this._menu,"popper","static")}_isShown(t=this._element){return t.classList.contains(Je)}_getMenuElement(){return V.next(this._element,ei)[0]}_getPlacement(){const t=this._element.parentNode;if(t.classList.contains("dropend"))return ri;if(t.classList.contains("dropstart"))return ai;const e="end"===getComputedStyle(this._menu).getPropertyValue("--bs-position").trim();return t.classList.contains("dropup")?e?ni:ii:e?oi:si}_detectNavbar(){return null!==this._element.closest(".navbar")}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_getPopperConfig(){const t={placement:this._getPlacement(),modifiers:[{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"offset",options:{offset:this._getOffset()}}]};return"static"===this._config.display&&(t.modifiers=[{name:"applyStyles",enabled:!1}]),{...t,..."function"==typeof this._config.popperConfig?this._config.popperConfig(t):this._config.popperConfig}}_selectMenuItem({key:t,target:e}){const i=V.find(".dropdown-menu .dropdown-item:not(.disabled):not(:disabled)",this._menu).filter(l);i.length&&v(i,e,t===Ye,!i.includes(e)).focus()}static jQueryInterface(t){return this.each((function(){const e=hi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}static clearMenus(t){if(t&&(2===t.button||"keyup"===t.type&&"Tab"!==t.key))return;const e=V.find(ti);for(let i=0,n=e.length;ie+t)),this._setElementAttributes(di,"paddingRight",(e=>e+t)),this._setElementAttributes(ui,"marginRight",(e=>e-t))}_disableOverFlow(){this._saveInitialAttribute(this._element,"overflow"),this._element.style.overflow="hidden"}_setElementAttributes(t,e,i){const n=this.getWidth();this._applyManipulationCallback(t,(t=>{if(t!==this._element&&window.innerWidth>t.clientWidth+n)return;this._saveInitialAttribute(t,e);const s=window.getComputedStyle(t)[e];t.style[e]=`${i(Number.parseFloat(s))}px`}))}reset(){this._resetElementAttributes(this._element,"overflow"),this._resetElementAttributes(this._element,"paddingRight"),this._resetElementAttributes(di,"paddingRight"),this._resetElementAttributes(ui,"marginRight")}_saveInitialAttribute(t,e){const i=t.style[e];i&&U.setDataAttribute(t,e,i)}_resetElementAttributes(t,e){this._applyManipulationCallback(t,(t=>{const i=U.getDataAttribute(t,e);void 0===i?t.style.removeProperty(e):(U.removeDataAttribute(t,e),t.style[e]=i)}))}_applyManipulationCallback(t,e){o(t)?e(t):V.find(t,this._element).forEach(e)}isOverflowing(){return this.getWidth()>0}}const pi={className:"modal-backdrop",isVisible:!0,isAnimated:!1,rootElement:"body",clickCallback:null},mi={className:"string",isVisible:"boolean",isAnimated:"boolean",rootElement:"(element|string)",clickCallback:"(function|null)"},gi="show",_i="mousedown.bs.backdrop";class bi{constructor(t){this._config=this._getConfig(t),this._isAppended=!1,this._element=null}show(t){this._config.isVisible?(this._append(),this._config.isAnimated&&u(this._getElement()),this._getElement().classList.add(gi),this._emulateAnimation((()=>{_(t)}))):_(t)}hide(t){this._config.isVisible?(this._getElement().classList.remove(gi),this._emulateAnimation((()=>{this.dispose(),_(t)}))):_(t)}_getElement(){if(!this._element){const t=document.createElement("div");t.className=this._config.className,this._config.isAnimated&&t.classList.add("fade"),this._element=t}return this._element}_getConfig(t){return(t={...pi,..."object"==typeof t?t:{}}).rootElement=r(t.rootElement),a("backdrop",t,mi),t}_append(){this._isAppended||(this._config.rootElement.append(this._getElement()),j.on(this._getElement(),_i,(()=>{_(this._config.clickCallback)})),this._isAppended=!0)}dispose(){this._isAppended&&(j.off(this._element,_i),this._element.remove(),this._isAppended=!1)}_emulateAnimation(t){b(t,this._getElement(),this._config.isAnimated)}}const vi={trapElement:null,autofocus:!0},yi={trapElement:"element",autofocus:"boolean"},wi=".bs.focustrap",Ei="backward";class Ai{constructor(t){this._config=this._getConfig(t),this._isActive=!1,this._lastTabNavDirection=null}activate(){const{trapElement:t,autofocus:e}=this._config;this._isActive||(e&&t.focus(),j.off(document,wi),j.on(document,"focusin.bs.focustrap",(t=>this._handleFocusin(t))),j.on(document,"keydown.tab.bs.focustrap",(t=>this._handleKeydown(t))),this._isActive=!0)}deactivate(){this._isActive&&(this._isActive=!1,j.off(document,wi))}_handleFocusin(t){const{target:e}=t,{trapElement:i}=this._config;if(e===document||e===i||i.contains(e))return;const n=V.focusableChildren(i);0===n.length?i.focus():this._lastTabNavDirection===Ei?n[n.length-1].focus():n[0].focus()}_handleKeydown(t){"Tab"===t.key&&(this._lastTabNavDirection=t.shiftKey?Ei:"forward")}_getConfig(t){return t={...vi,..."object"==typeof t?t:{}},a("focustrap",t,yi),t}}const Ti="modal",Oi="Escape",Ci={backdrop:!0,keyboard:!0,focus:!0},ki={backdrop:"(boolean|string)",keyboard:"boolean",focus:"boolean"},Li="hidden.bs.modal",xi="show.bs.modal",Di="resize.bs.modal",Si="click.dismiss.bs.modal",Ni="keydown.dismiss.bs.modal",Ii="mousedown.dismiss.bs.modal",Pi="modal-open",ji="show",Mi="modal-static";class Hi extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._dialog=V.findOne(".modal-dialog",this._element),this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._isShown=!1,this._ignoreBackdropClick=!1,this._isTransitioning=!1,this._scrollBar=new fi}static get Default(){return Ci}static get NAME(){return Ti}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||this._isTransitioning||j.trigger(this._element,xi,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._isAnimated()&&(this._isTransitioning=!0),this._scrollBar.hide(),document.body.classList.add(Pi),this._adjustDialog(),this._setEscapeEvent(),this._setResizeEvent(),j.on(this._dialog,Ii,(()=>{j.one(this._element,"mouseup.dismiss.bs.modal",(t=>{t.target===this._element&&(this._ignoreBackdropClick=!0)}))})),this._showBackdrop((()=>this._showElement(t))))}hide(){if(!this._isShown||this._isTransitioning)return;if(j.trigger(this._element,"hide.bs.modal").defaultPrevented)return;this._isShown=!1;const t=this._isAnimated();t&&(this._isTransitioning=!0),this._setEscapeEvent(),this._setResizeEvent(),this._focustrap.deactivate(),this._element.classList.remove(ji),j.off(this._element,Si),j.off(this._dialog,Ii),this._queueCallback((()=>this._hideModal()),this._element,t)}dispose(){[window,this._dialog].forEach((t=>j.off(t,".bs.modal"))),this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}handleUpdate(){this._adjustDialog()}_initializeBackDrop(){return new bi({isVisible:Boolean(this._config.backdrop),isAnimated:this._isAnimated()})}_initializeFocusTrap(){return new Ai({trapElement:this._element})}_getConfig(t){return t={...Ci,...U.getDataAttributes(this._element),..."object"==typeof t?t:{}},a(Ti,t,ki),t}_showElement(t){const e=this._isAnimated(),i=V.findOne(".modal-body",this._dialog);this._element.parentNode&&this._element.parentNode.nodeType===Node.ELEMENT_NODE||document.body.append(this._element),this._element.style.display="block",this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.scrollTop=0,i&&(i.scrollTop=0),e&&u(this._element),this._element.classList.add(ji),this._queueCallback((()=>{this._config.focus&&this._focustrap.activate(),this._isTransitioning=!1,j.trigger(this._element,"shown.bs.modal",{relatedTarget:t})}),this._dialog,e)}_setEscapeEvent(){this._isShown?j.on(this._element,Ni,(t=>{this._config.keyboard&&t.key===Oi?(t.preventDefault(),this.hide()):this._config.keyboard||t.key!==Oi||this._triggerBackdropTransition()})):j.off(this._element,Ni)}_setResizeEvent(){this._isShown?j.on(window,Di,(()=>this._adjustDialog())):j.off(window,Di)}_hideModal(){this._element.style.display="none",this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._isTransitioning=!1,this._backdrop.hide((()=>{document.body.classList.remove(Pi),this._resetAdjustments(),this._scrollBar.reset(),j.trigger(this._element,Li)}))}_showBackdrop(t){j.on(this._element,Si,(t=>{this._ignoreBackdropClick?this._ignoreBackdropClick=!1:t.target===t.currentTarget&&(!0===this._config.backdrop?this.hide():"static"===this._config.backdrop&&this._triggerBackdropTransition())})),this._backdrop.show(t)}_isAnimated(){return this._element.classList.contains("fade")}_triggerBackdropTransition(){if(j.trigger(this._element,"hidePrevented.bs.modal").defaultPrevented)return;const{classList:t,scrollHeight:e,style:i}=this._element,n=e>document.documentElement.clientHeight;!n&&"hidden"===i.overflowY||t.contains(Mi)||(n||(i.overflowY="hidden"),t.add(Mi),this._queueCallback((()=>{t.remove(Mi),n||this._queueCallback((()=>{i.overflowY=""}),this._dialog)}),this._dialog),this._element.focus())}_adjustDialog(){const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._scrollBar.getWidth(),i=e>0;(!i&&t&&!m()||i&&!t&&m())&&(this._element.style.paddingLeft=`${e}px`),(i&&!t&&!m()||!i&&t&&m())&&(this._element.style.paddingRight=`${e}px`)}_resetAdjustments(){this._element.style.paddingLeft="",this._element.style.paddingRight=""}static jQueryInterface(t,e){return this.each((function(){const i=Hi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===i[t])throw new TypeError(`No method named "${t}"`);i[t](e)}}))}}j.on(document,"click.bs.modal.data-api",'[data-bs-toggle="modal"]',(function(t){const e=n(this);["A","AREA"].includes(this.tagName)&&t.preventDefault(),j.one(e,xi,(t=>{t.defaultPrevented||j.one(e,Li,(()=>{l(this)&&this.focus()}))}));const i=V.findOne(".modal.show");i&&Hi.getInstance(i).hide(),Hi.getOrCreateInstance(e).toggle(this)})),R(Hi),g(Hi);const Bi="offcanvas",Ri={backdrop:!0,keyboard:!0,scroll:!1},Wi={backdrop:"boolean",keyboard:"boolean",scroll:"boolean"},$i="show",zi=".offcanvas.show",qi="hidden.bs.offcanvas";class Fi extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._isShown=!1,this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._addEventListeners()}static get NAME(){return Bi}static get Default(){return Ri}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||j.trigger(this._element,"show.bs.offcanvas",{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._element.style.visibility="visible",this._backdrop.show(),this._config.scroll||(new fi).hide(),this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.classList.add($i),this._queueCallback((()=>{this._config.scroll||this._focustrap.activate(),j.trigger(this._element,"shown.bs.offcanvas",{relatedTarget:t})}),this._element,!0))}hide(){this._isShown&&(j.trigger(this._element,"hide.bs.offcanvas").defaultPrevented||(this._focustrap.deactivate(),this._element.blur(),this._isShown=!1,this._element.classList.remove($i),this._backdrop.hide(),this._queueCallback((()=>{this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._element.style.visibility="hidden",this._config.scroll||(new fi).reset(),j.trigger(this._element,qi)}),this._element,!0)))}dispose(){this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}_getConfig(t){return t={...Ri,...U.getDataAttributes(this._element),..."object"==typeof t?t:{}},a(Bi,t,Wi),t}_initializeBackDrop(){return new bi({className:"offcanvas-backdrop",isVisible:this._config.backdrop,isAnimated:!0,rootElement:this._element.parentNode,clickCallback:()=>this.hide()})}_initializeFocusTrap(){return new Ai({trapElement:this._element})}_addEventListeners(){j.on(this._element,"keydown.dismiss.bs.offcanvas",(t=>{this._config.keyboard&&"Escape"===t.key&&this.hide()}))}static jQueryInterface(t){return this.each((function(){const e=Fi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}j.on(document,"click.bs.offcanvas.data-api",'[data-bs-toggle="offcanvas"]',(function(t){const e=n(this);if(["A","AREA"].includes(this.tagName)&&t.preventDefault(),c(this))return;j.one(e,qi,(()=>{l(this)&&this.focus()}));const i=V.findOne(zi);i&&i!==e&&Fi.getInstance(i).hide(),Fi.getOrCreateInstance(e).toggle(this)})),j.on(window,"load.bs.offcanvas.data-api",(()=>V.find(zi).forEach((t=>Fi.getOrCreateInstance(t).show())))),R(Fi),g(Fi);const Ui=new Set(["background","cite","href","itemtype","longdesc","poster","src","xlink:href"]),Vi=/^(?:(?:https?|mailto|ftp|tel|file|sms):|[^#&/:?]*(?:[#/?]|$))/i,Ki=/^data:(?:image\/(?:bmp|gif|jpeg|jpg|png|tiff|webp)|video\/(?:mpeg|mp4|ogg|webm)|audio\/(?:mp3|oga|ogg|opus));base64,[\d+/a-z]+=*$/i,Xi=(t,e)=>{const i=t.nodeName.toLowerCase();if(e.includes(i))return!Ui.has(i)||Boolean(Vi.test(t.nodeValue)||Ki.test(t.nodeValue));const n=e.filter((t=>t instanceof RegExp));for(let t=0,e=n.length;t{Xi(t,r)||i.removeAttribute(t.nodeName)}))}return n.body.innerHTML}const Qi="tooltip",Gi=new Set(["sanitize","allowList","sanitizeFn"]),Zi={animation:"boolean",template:"string",title:"(string|element|function)",trigger:"string",delay:"(number|object)",html:"boolean",selector:"(string|boolean)",placement:"(string|function)",offset:"(array|string|function)",container:"(string|element|boolean)",fallbackPlacements:"array",boundary:"(string|element)",customClass:"(string|function)",sanitize:"boolean",sanitizeFn:"(null|function)",allowList:"object",popperConfig:"(null|object|function)"},Ji={AUTO:"auto",TOP:"top",RIGHT:m()?"left":"right",BOTTOM:"bottom",LEFT:m()?"right":"left"},tn={animation:!0,template:'',trigger:"hover focus",title:"",delay:0,html:!1,selector:!1,placement:"top",offset:[0,0],container:!1,fallbackPlacements:["top","right","bottom","left"],boundary:"clippingParents",customClass:"",sanitize:!0,sanitizeFn:null,allowList:{"*":["class","dir","id","lang","role",/^aria-[\w-]*$/i],a:["target","href","title","rel"],area:[],b:[],br:[],col:[],code:[],div:[],em:[],hr:[],h1:[],h2:[],h3:[],h4:[],h5:[],h6:[],i:[],img:["src","srcset","alt","title","width","height"],li:[],ol:[],p:[],pre:[],s:[],small:[],span:[],sub:[],sup:[],strong:[],u:[],ul:[]},popperConfig:null},en={HIDE:"hide.bs.tooltip",HIDDEN:"hidden.bs.tooltip",SHOW:"show.bs.tooltip",SHOWN:"shown.bs.tooltip",INSERTED:"inserted.bs.tooltip",CLICK:"click.bs.tooltip",FOCUSIN:"focusin.bs.tooltip",FOCUSOUT:"focusout.bs.tooltip",MOUSEENTER:"mouseenter.bs.tooltip",MOUSELEAVE:"mouseleave.bs.tooltip"},nn="fade",sn="show",on="show",rn="out",an=".tooltip-inner",ln=".modal",cn="hide.bs.modal",hn="hover",dn="focus";class un extends B{constructor(t,e){if(void 0===Fe)throw new TypeError("Bootstrap's tooltips require Popper (https://popper.js.org)");super(t),this._isEnabled=!0,this._timeout=0,this._hoverState="",this._activeTrigger={},this._popper=null,this._config=this._getConfig(e),this.tip=null,this._setListeners()}static get Default(){return tn}static get NAME(){return Qi}static get Event(){return en}static get DefaultType(){return Zi}enable(){this._isEnabled=!0}disable(){this._isEnabled=!1}toggleEnabled(){this._isEnabled=!this._isEnabled}toggle(t){if(this._isEnabled)if(t){const e=this._initializeOnDelegatedTarget(t);e._activeTrigger.click=!e._activeTrigger.click,e._isWithActiveTrigger()?e._enter(null,e):e._leave(null,e)}else{if(this.getTipElement().classList.contains(sn))return void this._leave(null,this);this._enter(null,this)}}dispose(){clearTimeout(this._timeout),j.off(this._element.closest(ln),cn,this._hideModalHandler),this.tip&&this.tip.remove(),this._disposePopper(),super.dispose()}show(){if("none"===this._element.style.display)throw new Error("Please use show on visible elements");if(!this.isWithContent()||!this._isEnabled)return;const t=j.trigger(this._element,this.constructor.Event.SHOW),e=h(this._element),i=null===e?this._element.ownerDocument.documentElement.contains(this._element):e.contains(this._element);if(t.defaultPrevented||!i)return;"tooltip"===this.constructor.NAME&&this.tip&&this.getTitle()!==this.tip.querySelector(an).innerHTML&&(this._disposePopper(),this.tip.remove(),this.tip=null);const n=this.getTipElement(),s=(t=>{do{t+=Math.floor(1e6*Math.random())}while(document.getElementById(t));return t})(this.constructor.NAME);n.setAttribute("id",s),this._element.setAttribute("aria-describedby",s),this._config.animation&&n.classList.add(nn);const o="function"==typeof this._config.placement?this._config.placement.call(this,n,this._element):this._config.placement,r=this._getAttachment(o);this._addAttachmentClass(r);const{container:a}=this._config;H.set(n,this.constructor.DATA_KEY,this),this._element.ownerDocument.documentElement.contains(this.tip)||(a.append(n),j.trigger(this._element,this.constructor.Event.INSERTED)),this._popper?this._popper.update():this._popper=qe(this._element,n,this._getPopperConfig(r)),n.classList.add(sn);const l=this._resolvePossibleFunction(this._config.customClass);l&&n.classList.add(...l.split(" ")),"ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>{j.on(t,"mouseover",d)}));const c=this.tip.classList.contains(nn);this._queueCallback((()=>{const t=this._hoverState;this._hoverState=null,j.trigger(this._element,this.constructor.Event.SHOWN),t===rn&&this._leave(null,this)}),this.tip,c)}hide(){if(!this._popper)return;const t=this.getTipElement();if(j.trigger(this._element,this.constructor.Event.HIDE).defaultPrevented)return;t.classList.remove(sn),"ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>j.off(t,"mouseover",d))),this._activeTrigger.click=!1,this._activeTrigger.focus=!1,this._activeTrigger.hover=!1;const e=this.tip.classList.contains(nn);this._queueCallback((()=>{this._isWithActiveTrigger()||(this._hoverState!==on&&t.remove(),this._cleanTipClass(),this._element.removeAttribute("aria-describedby"),j.trigger(this._element,this.constructor.Event.HIDDEN),this._disposePopper())}),this.tip,e),this._hoverState=""}update(){null!==this._popper&&this._popper.update()}isWithContent(){return Boolean(this.getTitle())}getTipElement(){if(this.tip)return this.tip;const t=document.createElement("div");t.innerHTML=this._config.template;const e=t.children[0];return this.setContent(e),e.classList.remove(nn,sn),this.tip=e,this.tip}setContent(t){this._sanitizeAndSetContent(t,this.getTitle(),an)}_sanitizeAndSetContent(t,e,i){const n=V.findOne(i,t);e||!n?this.setElementContent(n,e):n.remove()}setElementContent(t,e){if(null!==t)return o(e)?(e=r(e),void(this._config.html?e.parentNode!==t&&(t.innerHTML="",t.append(e)):t.textContent=e.textContent)):void(this._config.html?(this._config.sanitize&&(e=Yi(e,this._config.allowList,this._config.sanitizeFn)),t.innerHTML=e):t.textContent=e)}getTitle(){const t=this._element.getAttribute("data-bs-original-title")||this._config.title;return this._resolvePossibleFunction(t)}updateAttachment(t){return"right"===t?"end":"left"===t?"start":t}_initializeOnDelegatedTarget(t,e){return e||this.constructor.getOrCreateInstance(t.delegateTarget,this._getDelegateConfig())}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_resolvePossibleFunction(t){return"function"==typeof t?t.call(this._element):t}_getPopperConfig(t){const e={placement:t,modifiers:[{name:"flip",options:{fallbackPlacements:this._config.fallbackPlacements}},{name:"offset",options:{offset:this._getOffset()}},{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"arrow",options:{element:`.${this.constructor.NAME}-arrow`}},{name:"onChange",enabled:!0,phase:"afterWrite",fn:t=>this._handlePopperPlacementChange(t)}],onFirstUpdate:t=>{t.options.placement!==t.placement&&this._handlePopperPlacementChange(t)}};return{...e,..."function"==typeof this._config.popperConfig?this._config.popperConfig(e):this._config.popperConfig}}_addAttachmentClass(t){this.getTipElement().classList.add(`${this._getBasicClassPrefix()}-${this.updateAttachment(t)}`)}_getAttachment(t){return Ji[t.toUpperCase()]}_setListeners(){this._config.trigger.split(" 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this._element.getAttribute("data-bs-original-title");(t||"string"!==e)&&(this._element.setAttribute("data-bs-original-title",t||""),!t||this._element.getAttribute("aria-label")||this._element.textContent||this._element.setAttribute("aria-label",t),this._element.setAttribute("title",""))}_enter(t,e){e=this._initializeOnDelegatedTarget(t,e),t&&(e._activeTrigger["focusin"===t.type?dn:hn]=!0),e.getTipElement().classList.contains(sn)||e._hoverState===on?e._hoverState=on:(clearTimeout(e._timeout),e._hoverState=on,e._config.delay&&e._config.delay.show?e._timeout=setTimeout((()=>{e._hoverState===on&&e.show()}),e._config.delay.show):e.show())}_leave(t,e){e=this._initializeOnDelegatedTarget(t,e),t&&(e._activeTrigger["focusout"===t.type?dn:hn]=e._element.contains(t.relatedTarget)),e._isWithActiveTrigger()||(clearTimeout(e._timeout),e._hoverState=rn,e._config.delay&&e._config.delay.hide?e._timeout=setTimeout((()=>{e._hoverState===rn&&e.hide()}),e._config.delay.hide):e.hide())}_isWithActiveTrigger(){for(const 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* --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): util/index.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nconst MAX_UID = 1000000\nconst MILLISECONDS_MULTIPLIER = 1000\nconst TRANSITION_END = 'transitionend'\n\n// Shoutout AngusCroll (https://goo.gl/pxwQGp)\nconst toType = obj => {\n if (obj === null || obj === undefined) {\n return `${obj}`\n }\n\n return {}.toString.call(obj).match(/\\s([a-z]+)/i)[1].toLowerCase()\n}\n\n/**\n * --------------------------------------------------------------------------\n * Public Util Api\n * --------------------------------------------------------------------------\n */\n\nconst getUID = prefix => {\n do {\n prefix += Math.floor(Math.random() * MAX_UID)\n } while (document.getElementById(prefix))\n\n return prefix\n}\n\nconst getSelector = element => {\n let selector = element.getAttribute('data-bs-target')\n\n if (!selector || selector === '#') {\n let hrefAttr = element.getAttribute('href')\n\n // The only valid content that could double as a selector are IDs or classes,\n // so everything starting with `#` or `.`. If a \"real\" URL is used as the selector,\n // `document.querySelector` will rightfully complain it is invalid.\n // See https://github.com/twbs/bootstrap/issues/32273\n if (!hrefAttr || (!hrefAttr.includes('#') && !hrefAttr.startsWith('.'))) {\n return null\n }\n\n // Just in case some CMS puts out a full URL with the anchor appended\n if (hrefAttr.includes('#') && !hrefAttr.startsWith('#')) {\n hrefAttr = `#${hrefAttr.split('#')[1]}`\n }\n\n selector = hrefAttr && hrefAttr !== '#' ? hrefAttr.trim() : null\n }\n\n return selector\n}\n\nconst getSelectorFromElement = element => {\n const selector = getSelector(element)\n\n if (selector) {\n return document.querySelector(selector) ? selector : null\n }\n\n return null\n}\n\nconst getElementFromSelector = element => {\n const selector = getSelector(element)\n\n return selector ? document.querySelector(selector) : null\n}\n\nconst getTransitionDurationFromElement = element => {\n if (!element) {\n return 0\n }\n\n // Get transition-duration of the element\n let { transitionDuration, transitionDelay } = window.getComputedStyle(element)\n\n const floatTransitionDuration = Number.parseFloat(transitionDuration)\n const floatTransitionDelay = Number.parseFloat(transitionDelay)\n\n // Return 0 if element or transition duration is not found\n if (!floatTransitionDuration && !floatTransitionDelay) {\n return 0\n }\n\n // If multiple durations are defined, take the first\n transitionDuration = transitionDuration.split(',')[0]\n transitionDelay = transitionDelay.split(',')[0]\n\n return (Number.parseFloat(transitionDuration) + Number.parseFloat(transitionDelay)) * MILLISECONDS_MULTIPLIER\n}\n\nconst triggerTransitionEnd = element => {\n element.dispatchEvent(new Event(TRANSITION_END))\n}\n\nconst isElement = obj => {\n if (!obj || typeof obj !== 'object') {\n return false\n }\n\n if (typeof obj.jquery !== 'undefined') {\n obj = obj[0]\n }\n\n return typeof obj.nodeType !== 'undefined'\n}\n\nconst getElement = obj => {\n if (isElement(obj)) { // it's a jQuery object or a node element\n return obj.jquery ? obj[0] : obj\n }\n\n if (typeof obj === 'string' && obj.length > 0) {\n return document.querySelector(obj)\n }\n\n return null\n}\n\nconst typeCheckConfig = (componentName, config, configTypes) => {\n Object.keys(configTypes).forEach(property => {\n const expectedTypes = configTypes[property]\n const value = config[property]\n const valueType = value && isElement(value) ? 'element' : toType(value)\n\n if (!new RegExp(expectedTypes).test(valueType)) {\n throw new TypeError(\n `${componentName.toUpperCase()}: Option \"${property}\" provided type \"${valueType}\" but expected type \"${expectedTypes}\".`\n )\n }\n })\n}\n\nconst isVisible = element => {\n if (!isElement(element) || element.getClientRects().length === 0) {\n return false\n }\n\n return getComputedStyle(element).getPropertyValue('visibility') === 'visible'\n}\n\nconst isDisabled = element => {\n if (!element || element.nodeType !== Node.ELEMENT_NODE) {\n return true\n }\n\n if (element.classList.contains('disabled')) {\n return true\n }\n\n if (typeof element.disabled !== 'undefined') {\n return element.disabled\n }\n\n return element.hasAttribute('disabled') && element.getAttribute('disabled') !== 'false'\n}\n\nconst findShadowRoot = element => {\n if (!document.documentElement.attachShadow) {\n return null\n }\n\n // Can find the shadow root otherwise it'll return the document\n if (typeof element.getRootNode === 'function') {\n const root = element.getRootNode()\n return root instanceof ShadowRoot ? root : null\n }\n\n if (element instanceof ShadowRoot) {\n return element\n }\n\n // when we don't find a shadow root\n if (!element.parentNode) {\n return null\n }\n\n return findShadowRoot(element.parentNode)\n}\n\nconst noop = () => {}\n\n/**\n * Trick to restart an element's animation\n *\n * @param {HTMLElement} element\n * @return void\n *\n * @see https://www.charistheo.io/blog/2021/02/restart-a-css-animation-with-javascript/#restarting-a-css-animation\n */\nconst reflow = element => {\n // eslint-disable-next-line no-unused-expressions\n element.offsetHeight\n}\n\nconst getjQuery = () => {\n const { jQuery } = window\n\n if (jQuery && !document.body.hasAttribute('data-bs-no-jquery')) {\n return jQuery\n }\n\n return null\n}\n\nconst DOMContentLoadedCallbacks = []\n\nconst onDOMContentLoaded = callback => {\n if (document.readyState === 'loading') {\n // add listener on the first call when the document is in loading state\n if (!DOMContentLoadedCallbacks.length) {\n document.addEventListener('DOMContentLoaded', () => {\n DOMContentLoadedCallbacks.forEach(callback => callback())\n })\n }\n\n DOMContentLoadedCallbacks.push(callback)\n } else {\n callback()\n }\n}\n\nconst isRTL = () => document.documentElement.dir === 'rtl'\n\nconst defineJQueryPlugin = plugin => {\n onDOMContentLoaded(() => {\n const $ = getjQuery()\n /* istanbul ignore if */\n if ($) {\n const name = plugin.NAME\n const JQUERY_NO_CONFLICT = $.fn[name]\n $.fn[name] = plugin.jQueryInterface\n $.fn[name].Constructor = plugin\n $.fn[name].noConflict = () => {\n $.fn[name] = JQUERY_NO_CONFLICT\n return plugin.jQueryInterface\n }\n }\n })\n}\n\nconst execute = callback => {\n if (typeof callback === 'function') {\n callback()\n }\n}\n\nconst executeAfterTransition = (callback, transitionElement, waitForTransition = true) => {\n if (!waitForTransition) {\n execute(callback)\n return\n }\n\n const durationPadding = 5\n const emulatedDuration = getTransitionDurationFromElement(transitionElement) + durationPadding\n\n let called = false\n\n const handler = ({ target }) => {\n if (target !== transitionElement) {\n return\n }\n\n called = true\n transitionElement.removeEventListener(TRANSITION_END, handler)\n execute(callback)\n }\n\n transitionElement.addEventListener(TRANSITION_END, handler)\n setTimeout(() => {\n if (!called) {\n triggerTransitionEnd(transitionElement)\n }\n }, emulatedDuration)\n}\n\n/**\n * Return the previous/next element of a list.\n *\n * @param {array} list The list of elements\n * @param activeElement The active element\n * @param shouldGetNext Choose to get next or previous element\n * @param isCycleAllowed\n * @return {Element|elem} The proper element\n */\nconst getNextActiveElement = (list, activeElement, shouldGetNext, isCycleAllowed) => {\n let index = list.indexOf(activeElement)\n\n // if the element does not exist in the list return an element depending on the direction and if cycle is allowed\n if (index === -1) {\n return list[!shouldGetNext && isCycleAllowed ? list.length - 1 : 0]\n }\n\n const listLength = list.length\n\n index += shouldGetNext ? 1 : -1\n\n if (isCycleAllowed) {\n index = (index + listLength) % listLength\n }\n\n return list[Math.max(0, Math.min(index, listLength - 1))]\n}\n\nexport {\n getElement,\n getUID,\n getSelectorFromElement,\n getElementFromSelector,\n getTransitionDurationFromElement,\n triggerTransitionEnd,\n isElement,\n typeCheckConfig,\n isVisible,\n isDisabled,\n findShadowRoot,\n noop,\n getNextActiveElement,\n reflow,\n getjQuery,\n onDOMContentLoaded,\n isRTL,\n defineJQueryPlugin,\n execute,\n executeAfterTransition\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): dom/event-handler.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { getjQuery } from '../util/index'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst namespaceRegex = /[^.]*(?=\\..*)\\.|.*/\nconst stripNameRegex = /\\..*/\nconst stripUidRegex = /::\\d+$/\nconst eventRegistry = {} // Events storage\nlet uidEvent = 1\nconst customEvents = {\n mouseenter: 'mouseover',\n mouseleave: 'mouseout'\n}\nconst customEventsRegex = /^(mouseenter|mouseleave)/i\nconst nativeEvents = new Set([\n 'click',\n 'dblclick',\n 'mouseup',\n 'mousedown',\n 'contextmenu',\n 'mousewheel',\n 'DOMMouseScroll',\n 'mouseover',\n 'mouseout',\n 'mousemove',\n 'selectstart',\n 'selectend',\n 'keydown',\n 'keypress',\n 'keyup',\n 'orientationchange',\n 'touchstart',\n 'touchmove',\n 'touchend',\n 'touchcancel',\n 'pointerdown',\n 'pointermove',\n 'pointerup',\n 'pointerleave',\n 'pointercancel',\n 'gesturestart',\n 'gesturechange',\n 'gestureend',\n 'focus',\n 'blur',\n 'change',\n 'reset',\n 'select',\n 'submit',\n 'focusin',\n 'focusout',\n 'load',\n 'unload',\n 'beforeunload',\n 'resize',\n 'move',\n 'DOMContentLoaded',\n 'readystatechange',\n 'error',\n 'abort',\n 'scroll'\n])\n\n/**\n * ------------------------------------------------------------------------\n * Private methods\n * ------------------------------------------------------------------------\n */\n\nfunction getUidEvent(element, uid) {\n return (uid && `${uid}::${uidEvent++}`) || element.uidEvent || uidEvent++\n}\n\nfunction getEvent(element) {\n const uid = getUidEvent(element)\n\n element.uidEvent = uid\n eventRegistry[uid] = eventRegistry[uid] || {}\n\n return eventRegistry[uid]\n}\n\nfunction bootstrapHandler(element, fn) {\n return function handler(event) {\n event.delegateTarget = element\n\n if (handler.oneOff) {\n EventHandler.off(element, event.type, fn)\n }\n\n return fn.apply(element, [event])\n }\n}\n\nfunction bootstrapDelegationHandler(element, selector, fn) {\n return function handler(event) {\n const domElements = element.querySelectorAll(selector)\n\n for (let { target } = event; target && target !== this; target = target.parentNode) {\n for (let i = domElements.length; i--;) {\n if (domElements[i] === target) {\n event.delegateTarget = target\n\n if (handler.oneOff) {\n EventHandler.off(element, event.type, selector, fn)\n }\n\n return fn.apply(target, [event])\n }\n }\n }\n\n // To please ESLint\n return null\n }\n}\n\nfunction findHandler(events, handler, delegationSelector = null) {\n const uidEventList = Object.keys(events)\n\n for (let i = 0, len = uidEventList.length; i < len; i++) {\n const event = events[uidEventList[i]]\n\n if (event.originalHandler === handler && event.delegationSelector === delegationSelector) {\n return event\n }\n }\n\n return null\n}\n\nfunction normalizeParams(originalTypeEvent, handler, delegationFn) {\n const delegation = typeof handler === 'string'\n const originalHandler = delegation ? delegationFn : handler\n\n let typeEvent = getTypeEvent(originalTypeEvent)\n const isNative = nativeEvents.has(typeEvent)\n\n if (!isNative) {\n typeEvent = originalTypeEvent\n }\n\n return [delegation, originalHandler, typeEvent]\n}\n\nfunction addHandler(element, originalTypeEvent, handler, delegationFn, oneOff) {\n if (typeof originalTypeEvent !== 'string' || !element) {\n return\n }\n\n if (!handler) {\n handler = delegationFn\n delegationFn = null\n }\n\n // in case of mouseenter or mouseleave wrap the handler within a function that checks for its DOM position\n // this prevents the handler from being dispatched the same way as mouseover or mouseout does\n if (customEventsRegex.test(originalTypeEvent)) {\n const wrapFn = fn => {\n return function (event) {\n if (!event.relatedTarget || (event.relatedTarget !== event.delegateTarget && !event.delegateTarget.contains(event.relatedTarget))) {\n return fn.call(this, event)\n }\n }\n }\n\n if (delegationFn) {\n delegationFn = wrapFn(delegationFn)\n } else {\n handler = wrapFn(handler)\n }\n }\n\n const [delegation, originalHandler, typeEvent] = normalizeParams(originalTypeEvent, handler, delegationFn)\n const events = getEvent(element)\n const handlers = events[typeEvent] || (events[typeEvent] = {})\n const previousFn = findHandler(handlers, originalHandler, delegation ? handler : null)\n\n if (previousFn) {\n previousFn.oneOff = previousFn.oneOff && oneOff\n\n return\n }\n\n const uid = getUidEvent(originalHandler, originalTypeEvent.replace(namespaceRegex, ''))\n const fn = delegation ?\n bootstrapDelegationHandler(element, handler, delegationFn) :\n bootstrapHandler(element, handler)\n\n fn.delegationSelector = delegation ? handler : null\n fn.originalHandler = originalHandler\n fn.oneOff = oneOff\n fn.uidEvent = uid\n handlers[uid] = fn\n\n element.addEventListener(typeEvent, fn, delegation)\n}\n\nfunction removeHandler(element, events, typeEvent, handler, delegationSelector) {\n const fn = findHandler(events[typeEvent], handler, delegationSelector)\n\n if (!fn) {\n return\n }\n\n element.removeEventListener(typeEvent, fn, Boolean(delegationSelector))\n delete events[typeEvent][fn.uidEvent]\n}\n\nfunction removeNamespacedHandlers(element, events, typeEvent, namespace) {\n const storeElementEvent = events[typeEvent] || {}\n\n Object.keys(storeElementEvent).forEach(handlerKey => {\n if (handlerKey.includes(namespace)) {\n const event = storeElementEvent[handlerKey]\n\n removeHandler(element, events, typeEvent, event.originalHandler, event.delegationSelector)\n }\n })\n}\n\nfunction getTypeEvent(event) {\n // allow to get the native events from namespaced events ('click.bs.button' --> 'click')\n event = event.replace(stripNameRegex, '')\n return customEvents[event] || event\n}\n\nconst EventHandler = {\n on(element, event, handler, delegationFn) {\n addHandler(element, event, handler, delegationFn, false)\n },\n\n one(element, event, handler, delegationFn) {\n addHandler(element, event, handler, delegationFn, true)\n },\n\n off(element, originalTypeEvent, handler, delegationFn) {\n if (typeof originalTypeEvent !== 'string' || !element) {\n return\n }\n\n const [delegation, originalHandler, typeEvent] = normalizeParams(originalTypeEvent, handler, delegationFn)\n const inNamespace = typeEvent !== originalTypeEvent\n const events = getEvent(element)\n const isNamespace = originalTypeEvent.startsWith('.')\n\n if (typeof originalHandler !== 'undefined') {\n // Simplest case: handler is passed, remove that listener ONLY.\n if (!events || !events[typeEvent]) {\n return\n }\n\n removeHandler(element, events, typeEvent, originalHandler, delegation ? handler : null)\n return\n }\n\n if (isNamespace) {\n Object.keys(events).forEach(elementEvent => {\n removeNamespacedHandlers(element, events, elementEvent, originalTypeEvent.slice(1))\n })\n }\n\n const storeElementEvent = events[typeEvent] || {}\n Object.keys(storeElementEvent).forEach(keyHandlers => {\n const handlerKey = keyHandlers.replace(stripUidRegex, '')\n\n if (!inNamespace || originalTypeEvent.includes(handlerKey)) {\n const event = storeElementEvent[keyHandlers]\n\n removeHandler(element, events, typeEvent, event.originalHandler, event.delegationSelector)\n }\n })\n },\n\n trigger(element, event, args) {\n if (typeof event !== 'string' || !element) {\n return null\n }\n\n const $ = getjQuery()\n const typeEvent = getTypeEvent(event)\n const inNamespace = event !== typeEvent\n const isNative = nativeEvents.has(typeEvent)\n\n let jQueryEvent\n let bubbles = true\n let nativeDispatch = true\n let defaultPrevented = false\n let evt = null\n\n if (inNamespace && $) {\n jQueryEvent = $.Event(event, args)\n\n $(element).trigger(jQueryEvent)\n bubbles = !jQueryEvent.isPropagationStopped()\n nativeDispatch = !jQueryEvent.isImmediatePropagationStopped()\n defaultPrevented = jQueryEvent.isDefaultPrevented()\n }\n\n if (isNative) {\n evt = document.createEvent('HTMLEvents')\n evt.initEvent(typeEvent, bubbles, true)\n } else {\n evt = new CustomEvent(event, {\n bubbles,\n cancelable: true\n })\n }\n\n // merge custom information in our event\n if (typeof args !== 'undefined') {\n Object.keys(args).forEach(key => {\n Object.defineProperty(evt, key, {\n get() {\n return args[key]\n }\n })\n })\n }\n\n if (defaultPrevented) {\n evt.preventDefault()\n }\n\n if (nativeDispatch) {\n element.dispatchEvent(evt)\n }\n\n if (evt.defaultPrevented && typeof jQueryEvent !== 'undefined') {\n jQueryEvent.preventDefault()\n }\n\n return evt\n }\n}\n\nexport default EventHandler\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): dom/data.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst elementMap = new Map()\n\nexport default {\n set(element, key, instance) {\n if (!elementMap.has(element)) {\n elementMap.set(element, new Map())\n }\n\n const instanceMap = elementMap.get(element)\n\n // make it clear we only want one instance per element\n // can be removed later when multiple key/instances are fine to be used\n if (!instanceMap.has(key) && instanceMap.size !== 0) {\n // eslint-disable-next-line no-console\n console.error(`Bootstrap doesn't allow more than one instance per element. Bound instance: ${Array.from(instanceMap.keys())[0]}.`)\n return\n }\n\n instanceMap.set(key, instance)\n },\n\n get(element, key) {\n if (elementMap.has(element)) {\n return elementMap.get(element).get(key) || null\n }\n\n return null\n },\n\n remove(element, key) {\n if (!elementMap.has(element)) {\n return\n }\n\n const instanceMap = elementMap.get(element)\n\n instanceMap.delete(key)\n\n // free up element references if there are no instances left for an element\n if (instanceMap.size === 0) {\n elementMap.delete(element)\n }\n }\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): base-component.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Data from './dom/data'\nimport {\n executeAfterTransition,\n getElement\n} from './util/index'\nimport EventHandler from './dom/event-handler'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst VERSION = '5.1.3'\n\nclass BaseComponent {\n constructor(element) {\n element = getElement(element)\n\n if (!element) {\n return\n }\n\n this._element = element\n Data.set(this._element, this.constructor.DATA_KEY, this)\n }\n\n dispose() {\n Data.remove(this._element, this.constructor.DATA_KEY)\n EventHandler.off(this._element, this.constructor.EVENT_KEY)\n\n Object.getOwnPropertyNames(this).forEach(propertyName => {\n this[propertyName] = null\n })\n }\n\n _queueCallback(callback, element, isAnimated = true) {\n executeAfterTransition(callback, element, isAnimated)\n }\n\n /** Static */\n\n static getInstance(element) {\n return Data.get(getElement(element), this.DATA_KEY)\n }\n\n static getOrCreateInstance(element, config = {}) {\n return this.getInstance(element) || new this(element, typeof config === 'object' ? config : null)\n }\n\n static get VERSION() {\n return VERSION\n }\n\n static get NAME() {\n throw new Error('You have to implement the static method \"NAME\", for each component!')\n }\n\n static get DATA_KEY() {\n return `bs.${this.NAME}`\n }\n\n static get EVENT_KEY() {\n return `.${this.DATA_KEY}`\n }\n}\n\nexport default BaseComponent\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): util/component-functions.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler'\nimport { getElementFromSelector, isDisabled } from './index'\n\nconst enableDismissTrigger = (component, method = 'hide') => {\n const clickEvent = `click.dismiss${component.EVENT_KEY}`\n const name = component.NAME\n\n EventHandler.on(document, clickEvent, `[data-bs-dismiss=\"${name}\"]`, function (event) {\n if (['A', 'AREA'].includes(this.tagName)) {\n event.preventDefault()\n }\n\n if (isDisabled(this)) {\n return\n }\n\n const target = getElementFromSelector(this) || this.closest(`.${name}`)\n const instance = component.getOrCreateInstance(target)\n\n // Method argument is left, for Alert and only, as it doesn't implement the 'hide' method\n instance[method]()\n })\n}\n\nexport {\n enableDismissTrigger\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): alert.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { defineJQueryPlugin } from './util/index'\nimport EventHandler from './dom/event-handler'\nimport BaseComponent from './base-component'\nimport { enableDismissTrigger } from './util/component-functions'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'alert'\nconst DATA_KEY = 'bs.alert'\nconst EVENT_KEY = `.${DATA_KEY}`\n\nconst EVENT_CLOSE = `close${EVENT_KEY}`\nconst EVENT_CLOSED = `closed${EVENT_KEY}`\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Alert extends BaseComponent {\n // Getters\n\n static get NAME() {\n return NAME\n }\n\n // Public\n\n close() {\n const closeEvent = EventHandler.trigger(this._element, EVENT_CLOSE)\n\n if (closeEvent.defaultPrevented) {\n return\n }\n\n this._element.classList.remove(CLASS_NAME_SHOW)\n\n const isAnimated = this._element.classList.contains(CLASS_NAME_FADE)\n this._queueCallback(() => this._destroyElement(), this._element, isAnimated)\n }\n\n // Private\n _destroyElement() {\n this._element.remove()\n EventHandler.trigger(this._element, EVENT_CLOSED)\n this.dispose()\n }\n\n // Static\n\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Alert.getOrCreateInstance(this)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config](this)\n })\n }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nenableDismissTrigger(Alert, 'close')\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Alert to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Alert)\n\nexport default Alert\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): button.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { defineJQueryPlugin } from './util/index'\nimport EventHandler from './dom/event-handler'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'button'\nconst DATA_KEY = 'bs.button'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst CLASS_NAME_ACTIVE = 'active'\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"button\"]'\n\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Button extends BaseComponent {\n // Getters\n\n static get NAME() {\n return NAME\n }\n\n // Public\n\n toggle() {\n // Toggle class and sync the `aria-pressed` attribute with the return value of the `.toggle()` method\n this._element.setAttribute('aria-pressed', this._element.classList.toggle(CLASS_NAME_ACTIVE))\n }\n\n // Static\n\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Button.getOrCreateInstance(this)\n\n if (config === 'toggle') {\n data[config]()\n }\n })\n }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, event => {\n event.preventDefault()\n\n const button = event.target.closest(SELECTOR_DATA_TOGGLE)\n const data = Button.getOrCreateInstance(button)\n\n data.toggle()\n})\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Button to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Button)\n\nexport default Button\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): dom/manipulator.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nfunction normalizeData(val) {\n if (val === 'true') {\n return true\n }\n\n if (val === 'false') {\n return false\n }\n\n if (val === Number(val).toString()) {\n return Number(val)\n }\n\n if (val === '' || val === 'null') {\n return null\n }\n\n return val\n}\n\nfunction normalizeDataKey(key) {\n return key.replace(/[A-Z]/g, chr => `-${chr.toLowerCase()}`)\n}\n\nconst Manipulator = {\n setDataAttribute(element, key, value) {\n element.setAttribute(`data-bs-${normalizeDataKey(key)}`, value)\n },\n\n removeDataAttribute(element, key) {\n element.removeAttribute(`data-bs-${normalizeDataKey(key)}`)\n },\n\n getDataAttributes(element) {\n if (!element) {\n return {}\n }\n\n const attributes = {}\n\n Object.keys(element.dataset)\n .filter(key => key.startsWith('bs'))\n .forEach(key => {\n let pureKey = key.replace(/^bs/, '')\n pureKey = pureKey.charAt(0).toLowerCase() + pureKey.slice(1, pureKey.length)\n attributes[pureKey] = normalizeData(element.dataset[key])\n })\n\n return attributes\n },\n\n getDataAttribute(element, key) {\n return normalizeData(element.getAttribute(`data-bs-${normalizeDataKey(key)}`))\n },\n\n offset(element) {\n const rect = element.getBoundingClientRect()\n\n return {\n top: rect.top + window.pageYOffset,\n left: rect.left + window.pageXOffset\n }\n },\n\n position(element) {\n return {\n top: element.offsetTop,\n left: element.offsetLeft\n }\n }\n}\n\nexport default Manipulator\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): dom/selector-engine.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nimport { isDisabled, isVisible } from '../util/index'\n\nconst NODE_TEXT = 3\n\nconst SelectorEngine = {\n find(selector, element = document.documentElement) {\n return [].concat(...Element.prototype.querySelectorAll.call(element, selector))\n },\n\n findOne(selector, element = document.documentElement) {\n return Element.prototype.querySelector.call(element, selector)\n },\n\n children(element, selector) {\n return [].concat(...element.children)\n .filter(child => child.matches(selector))\n },\n\n parents(element, selector) {\n const parents = []\n\n let ancestor = element.parentNode\n\n while (ancestor && ancestor.nodeType === Node.ELEMENT_NODE && ancestor.nodeType !== NODE_TEXT) {\n if (ancestor.matches(selector)) {\n parents.push(ancestor)\n }\n\n ancestor = ancestor.parentNode\n }\n\n return parents\n },\n\n prev(element, selector) {\n let previous = element.previousElementSibling\n\n while (previous) {\n if (previous.matches(selector)) {\n return [previous]\n }\n\n previous = previous.previousElementSibling\n }\n\n return []\n },\n\n next(element, selector) {\n let next = element.nextElementSibling\n\n while (next) {\n if (next.matches(selector)) {\n return [next]\n }\n\n next = next.nextElementSibling\n }\n\n return []\n },\n\n focusableChildren(element) {\n const focusables = [\n 'a',\n 'button',\n 'input',\n 'textarea',\n 'select',\n 'details',\n '[tabindex]',\n '[contenteditable=\"true\"]'\n ].map(selector => `${selector}:not([tabindex^=\"-\"])`).join(', ')\n\n return this.find(focusables, element).filter(el => !isDisabled(el) && isVisible(el))\n }\n}\n\nexport default SelectorEngine\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): carousel.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n defineJQueryPlugin,\n getElementFromSelector,\n isRTL,\n isVisible,\n getNextActiveElement,\n reflow,\n triggerTransitionEnd,\n typeCheckConfig\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'carousel'\nconst DATA_KEY = 'bs.carousel'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ARROW_LEFT_KEY = 'ArrowLeft'\nconst ARROW_RIGHT_KEY = 'ArrowRight'\nconst TOUCHEVENT_COMPAT_WAIT = 500 // Time for mouse compat events to fire after touch\nconst SWIPE_THRESHOLD = 40\n\nconst Default = {\n interval: 5000,\n keyboard: true,\n slide: false,\n pause: 'hover',\n wrap: true,\n touch: true\n}\n\nconst DefaultType = {\n interval: '(number|boolean)',\n keyboard: 'boolean',\n slide: '(boolean|string)',\n pause: '(string|boolean)',\n wrap: 'boolean',\n touch: 'boolean'\n}\n\nconst ORDER_NEXT = 'next'\nconst ORDER_PREV = 'prev'\nconst DIRECTION_LEFT = 'left'\nconst DIRECTION_RIGHT = 'right'\n\nconst KEY_TO_DIRECTION = {\n [ARROW_LEFT_KEY]: DIRECTION_RIGHT,\n [ARROW_RIGHT_KEY]: DIRECTION_LEFT\n}\n\nconst EVENT_SLIDE = `slide${EVENT_KEY}`\nconst EVENT_SLID = `slid${EVENT_KEY}`\nconst EVENT_KEYDOWN = `keydown${EVENT_KEY}`\nconst EVENT_MOUSEENTER = `mouseenter${EVENT_KEY}`\nconst EVENT_MOUSELEAVE = `mouseleave${EVENT_KEY}`\nconst EVENT_TOUCHSTART = `touchstart${EVENT_KEY}`\nconst EVENT_TOUCHMOVE = `touchmove${EVENT_KEY}`\nconst EVENT_TOUCHEND = `touchend${EVENT_KEY}`\nconst EVENT_POINTERDOWN = `pointerdown${EVENT_KEY}`\nconst EVENT_POINTERUP = `pointerup${EVENT_KEY}`\nconst EVENT_DRAG_START = `dragstart${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_CAROUSEL = 'carousel'\nconst CLASS_NAME_ACTIVE = 'active'\nconst CLASS_NAME_SLIDE = 'slide'\nconst CLASS_NAME_END = 'carousel-item-end'\nconst CLASS_NAME_START = 'carousel-item-start'\nconst CLASS_NAME_NEXT = 'carousel-item-next'\nconst CLASS_NAME_PREV = 'carousel-item-prev'\nconst CLASS_NAME_POINTER_EVENT = 'pointer-event'\n\nconst SELECTOR_ACTIVE = '.active'\nconst SELECTOR_ACTIVE_ITEM = '.active.carousel-item'\nconst SELECTOR_ITEM = '.carousel-item'\nconst SELECTOR_ITEM_IMG = '.carousel-item img'\nconst SELECTOR_NEXT_PREV = '.carousel-item-next, .carousel-item-prev'\nconst SELECTOR_INDICATORS = '.carousel-indicators'\nconst SELECTOR_INDICATOR = '[data-bs-target]'\nconst SELECTOR_DATA_SLIDE = '[data-bs-slide], [data-bs-slide-to]'\nconst SELECTOR_DATA_RIDE = '[data-bs-ride=\"carousel\"]'\n\nconst POINTER_TYPE_TOUCH = 'touch'\nconst POINTER_TYPE_PEN = 'pen'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\nclass Carousel extends BaseComponent {\n constructor(element, config) {\n super(element)\n\n this._items = null\n this._interval = null\n this._activeElement = null\n this._isPaused = false\n this._isSliding = false\n this.touchTimeout = null\n this.touchStartX = 0\n this.touchDeltaX = 0\n\n this._config = this._getConfig(config)\n this._indicatorsElement = SelectorEngine.findOne(SELECTOR_INDICATORS, this._element)\n this._touchSupported = 'ontouchstart' in document.documentElement || navigator.maxTouchPoints > 0\n this._pointerEvent = Boolean(window.PointerEvent)\n\n this._addEventListeners()\n }\n\n // Getters\n\n static get Default() {\n return Default\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n\n next() {\n this._slide(ORDER_NEXT)\n }\n\n nextWhenVisible() {\n // Don't call next when the page isn't visible\n // or the carousel or its parent isn't visible\n if (!document.hidden && isVisible(this._element)) {\n this.next()\n }\n }\n\n prev() {\n this._slide(ORDER_PREV)\n }\n\n pause(event) {\n if (!event) {\n this._isPaused = true\n }\n\n if (SelectorEngine.findOne(SELECTOR_NEXT_PREV, this._element)) {\n triggerTransitionEnd(this._element)\n this.cycle(true)\n }\n\n clearInterval(this._interval)\n this._interval = null\n }\n\n cycle(event) {\n if (!event) {\n this._isPaused = false\n }\n\n if (this._interval) {\n clearInterval(this._interval)\n this._interval = null\n }\n\n if (this._config && this._config.interval && !this._isPaused) {\n this._updateInterval()\n\n this._interval = setInterval(\n (document.visibilityState ? this.nextWhenVisible : this.next).bind(this),\n this._config.interval\n )\n }\n }\n\n to(index) {\n this._activeElement = SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element)\n const activeIndex = this._getItemIndex(this._activeElement)\n\n if (index > this._items.length - 1 || index < 0) {\n return\n }\n\n if (this._isSliding) {\n EventHandler.one(this._element, EVENT_SLID, () => this.to(index))\n return\n }\n\n if (activeIndex === index) {\n this.pause()\n this.cycle()\n return\n }\n\n const order = index > activeIndex ?\n ORDER_NEXT :\n ORDER_PREV\n\n this._slide(order, this._items[index])\n }\n\n // Private\n\n _getConfig(config) {\n config = {\n ...Default,\n ...Manipulator.getDataAttributes(this._element),\n ...(typeof config === 'object' ? config : {})\n }\n typeCheckConfig(NAME, config, DefaultType)\n return config\n }\n\n _handleSwipe() {\n const absDeltax = Math.abs(this.touchDeltaX)\n\n if (absDeltax <= SWIPE_THRESHOLD) {\n return\n }\n\n const direction = absDeltax / this.touchDeltaX\n\n this.touchDeltaX = 0\n\n if (!direction) {\n return\n }\n\n this._slide(direction > 0 ? DIRECTION_RIGHT : DIRECTION_LEFT)\n }\n\n _addEventListeners() {\n if (this._config.keyboard) {\n EventHandler.on(this._element, EVENT_KEYDOWN, event => this._keydown(event))\n }\n\n if (this._config.pause === 'hover') {\n EventHandler.on(this._element, EVENT_MOUSEENTER, event => this.pause(event))\n EventHandler.on(this._element, EVENT_MOUSELEAVE, event => this.cycle(event))\n }\n\n if (this._config.touch && this._touchSupported) {\n this._addTouchEventListeners()\n }\n }\n\n _addTouchEventListeners() {\n const hasPointerPenTouch = event => {\n return this._pointerEvent &&\n (event.pointerType === POINTER_TYPE_PEN || event.pointerType === POINTER_TYPE_TOUCH)\n }\n\n const start = event => {\n if (hasPointerPenTouch(event)) {\n this.touchStartX = event.clientX\n } else if (!this._pointerEvent) {\n this.touchStartX = event.touches[0].clientX\n }\n }\n\n const move = event => {\n // ensure swiping with one touch and not pinching\n this.touchDeltaX = event.touches && event.touches.length > 1 ?\n 0 :\n event.touches[0].clientX - this.touchStartX\n }\n\n const end = event => {\n if (hasPointerPenTouch(event)) {\n this.touchDeltaX = event.clientX - this.touchStartX\n }\n\n this._handleSwipe()\n if (this._config.pause === 'hover') {\n // If it's a touch-enabled device, mouseenter/leave are fired as\n // part of the mouse compatibility events on first tap - the carousel\n // would stop cycling until user tapped out of it;\n // here, we listen for touchend, explicitly pause the carousel\n // (as if it's the second time we tap on it, mouseenter compat event\n // is NOT fired) and after a timeout (to allow for mouse compatibility\n // events to fire) we explicitly restart cycling\n\n this.pause()\n if (this.touchTimeout) {\n clearTimeout(this.touchTimeout)\n }\n\n this.touchTimeout = setTimeout(event => this.cycle(event), TOUCHEVENT_COMPAT_WAIT + this._config.interval)\n }\n }\n\n SelectorEngine.find(SELECTOR_ITEM_IMG, this._element).forEach(itemImg => {\n EventHandler.on(itemImg, EVENT_DRAG_START, event => event.preventDefault())\n })\n\n if (this._pointerEvent) {\n EventHandler.on(this._element, EVENT_POINTERDOWN, event => start(event))\n EventHandler.on(this._element, EVENT_POINTERUP, event => end(event))\n\n this._element.classList.add(CLASS_NAME_POINTER_EVENT)\n } else {\n EventHandler.on(this._element, EVENT_TOUCHSTART, event => start(event))\n EventHandler.on(this._element, EVENT_TOUCHMOVE, event => move(event))\n EventHandler.on(this._element, EVENT_TOUCHEND, event => end(event))\n }\n }\n\n _keydown(event) {\n if (/input|textarea/i.test(event.target.tagName)) {\n return\n }\n\n const direction = KEY_TO_DIRECTION[event.key]\n if (direction) {\n event.preventDefault()\n this._slide(direction)\n }\n }\n\n _getItemIndex(element) {\n this._items = element && element.parentNode ?\n SelectorEngine.find(SELECTOR_ITEM, element.parentNode) :\n []\n\n return this._items.indexOf(element)\n }\n\n _getItemByOrder(order, activeElement) {\n const isNext = order === ORDER_NEXT\n return getNextActiveElement(this._items, activeElement, isNext, this._config.wrap)\n }\n\n _triggerSlideEvent(relatedTarget, eventDirectionName) {\n const targetIndex = this._getItemIndex(relatedTarget)\n const fromIndex = this._getItemIndex(SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element))\n\n return EventHandler.trigger(this._element, EVENT_SLIDE, {\n relatedTarget,\n direction: eventDirectionName,\n from: fromIndex,\n to: targetIndex\n })\n }\n\n _setActiveIndicatorElement(element) {\n if (this._indicatorsElement) {\n const activeIndicator = SelectorEngine.findOne(SELECTOR_ACTIVE, this._indicatorsElement)\n\n activeIndicator.classList.remove(CLASS_NAME_ACTIVE)\n activeIndicator.removeAttribute('aria-current')\n\n const indicators = SelectorEngine.find(SELECTOR_INDICATOR, this._indicatorsElement)\n\n for (let i = 0; i < indicators.length; i++) {\n if (Number.parseInt(indicators[i].getAttribute('data-bs-slide-to'), 10) === this._getItemIndex(element)) {\n indicators[i].classList.add(CLASS_NAME_ACTIVE)\n indicators[i].setAttribute('aria-current', 'true')\n break\n }\n }\n }\n }\n\n _updateInterval() {\n const element = this._activeElement || SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element)\n\n if (!element) {\n return\n }\n\n const elementInterval = Number.parseInt(element.getAttribute('data-bs-interval'), 10)\n\n if (elementInterval) {\n this._config.defaultInterval = this._config.defaultInterval || this._config.interval\n this._config.interval = elementInterval\n } else {\n this._config.interval = this._config.defaultInterval || this._config.interval\n }\n }\n\n _slide(directionOrOrder, element) {\n const order = this._directionToOrder(directionOrOrder)\n const activeElement = SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element)\n const activeElementIndex = this._getItemIndex(activeElement)\n const nextElement = element || this._getItemByOrder(order, activeElement)\n\n const nextElementIndex = this._getItemIndex(nextElement)\n const isCycling = Boolean(this._interval)\n\n const isNext = order === ORDER_NEXT\n const directionalClassName = isNext ? CLASS_NAME_START : CLASS_NAME_END\n const orderClassName = isNext ? CLASS_NAME_NEXT : CLASS_NAME_PREV\n const eventDirectionName = this._orderToDirection(order)\n\n if (nextElement && nextElement.classList.contains(CLASS_NAME_ACTIVE)) {\n this._isSliding = false\n return\n }\n\n if (this._isSliding) {\n return\n }\n\n const slideEvent = this._triggerSlideEvent(nextElement, eventDirectionName)\n if (slideEvent.defaultPrevented) {\n return\n }\n\n if (!activeElement || !nextElement) {\n // Some weirdness is happening, so we bail\n return\n }\n\n this._isSliding = true\n\n if (isCycling) {\n this.pause()\n }\n\n this._setActiveIndicatorElement(nextElement)\n this._activeElement = nextElement\n\n const triggerSlidEvent = () => {\n EventHandler.trigger(this._element, EVENT_SLID, {\n relatedTarget: nextElement,\n direction: eventDirectionName,\n from: activeElementIndex,\n to: nextElementIndex\n })\n }\n\n if (this._element.classList.contains(CLASS_NAME_SLIDE)) {\n nextElement.classList.add(orderClassName)\n\n reflow(nextElement)\n\n activeElement.classList.add(directionalClassName)\n nextElement.classList.add(directionalClassName)\n\n const completeCallBack = () => {\n nextElement.classList.remove(directionalClassName, orderClassName)\n nextElement.classList.add(CLASS_NAME_ACTIVE)\n\n activeElement.classList.remove(CLASS_NAME_ACTIVE, orderClassName, directionalClassName)\n\n this._isSliding = false\n\n setTimeout(triggerSlidEvent, 0)\n }\n\n this._queueCallback(completeCallBack, activeElement, true)\n } else {\n activeElement.classList.remove(CLASS_NAME_ACTIVE)\n nextElement.classList.add(CLASS_NAME_ACTIVE)\n\n this._isSliding = false\n triggerSlidEvent()\n }\n\n if (isCycling) {\n this.cycle()\n }\n }\n\n _directionToOrder(direction) {\n if (![DIRECTION_RIGHT, DIRECTION_LEFT].includes(direction)) {\n return direction\n }\n\n if (isRTL()) {\n return direction === DIRECTION_LEFT ? ORDER_PREV : ORDER_NEXT\n }\n\n return direction === DIRECTION_LEFT ? ORDER_NEXT : ORDER_PREV\n }\n\n _orderToDirection(order) {\n if (![ORDER_NEXT, ORDER_PREV].includes(order)) {\n return order\n }\n\n if (isRTL()) {\n return order === ORDER_PREV ? DIRECTION_LEFT : DIRECTION_RIGHT\n }\n\n return order === ORDER_PREV ? DIRECTION_RIGHT : DIRECTION_LEFT\n }\n\n // Static\n\n static carouselInterface(element, config) {\n const data = Carousel.getOrCreateInstance(element, config)\n\n let { _config } = data\n if (typeof config === 'object') {\n _config = {\n ..._config,\n ...config\n }\n }\n\n const action = typeof config === 'string' ? config : _config.slide\n\n if (typeof config === 'number') {\n data.to(config)\n } else if (typeof action === 'string') {\n if (typeof data[action] === 'undefined') {\n throw new TypeError(`No method named \"${action}\"`)\n }\n\n data[action]()\n } else if (_config.interval && _config.ride) {\n data.pause()\n data.cycle()\n }\n }\n\n static jQueryInterface(config) {\n return this.each(function () {\n Carousel.carouselInterface(this, config)\n })\n }\n\n static dataApiClickHandler(event) {\n const target = getElementFromSelector(this)\n\n if (!target || !target.classList.contains(CLASS_NAME_CAROUSEL)) {\n return\n }\n\n const config = {\n ...Manipulator.getDataAttributes(target),\n ...Manipulator.getDataAttributes(this)\n }\n const slideIndex = this.getAttribute('data-bs-slide-to')\n\n if (slideIndex) {\n config.interval = false\n }\n\n Carousel.carouselInterface(target, config)\n\n if (slideIndex) {\n Carousel.getInstance(target).to(slideIndex)\n }\n\n event.preventDefault()\n }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_SLIDE, Carousel.dataApiClickHandler)\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n const carousels = SelectorEngine.find(SELECTOR_DATA_RIDE)\n\n for (let i = 0, len = carousels.length; i < len; i++) {\n Carousel.carouselInterface(carousels[i], Carousel.getInstance(carousels[i]))\n }\n})\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Carousel to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Carousel)\n\nexport default Carousel\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): collapse.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n defineJQueryPlugin,\n getElement,\n getSelectorFromElement,\n getElementFromSelector,\n reflow,\n typeCheckConfig\n} from './util/index'\nimport Data from './dom/data'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'collapse'\nconst DATA_KEY = 'bs.collapse'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst Default = {\n toggle: true,\n parent: null\n}\n\nconst DefaultType = {\n toggle: 'boolean',\n parent: '(null|element)'\n}\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_COLLAPSE = 'collapse'\nconst CLASS_NAME_COLLAPSING = 'collapsing'\nconst CLASS_NAME_COLLAPSED = 'collapsed'\nconst CLASS_NAME_DEEPER_CHILDREN = `:scope .${CLASS_NAME_COLLAPSE} .${CLASS_NAME_COLLAPSE}`\nconst CLASS_NAME_HORIZONTAL = 'collapse-horizontal'\n\nconst WIDTH = 'width'\nconst HEIGHT = 'height'\n\nconst SELECTOR_ACTIVES = '.collapse.show, .collapse.collapsing'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"collapse\"]'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Collapse extends BaseComponent {\n constructor(element, config) {\n super(element)\n\n this._isTransitioning = false\n this._config = this._getConfig(config)\n this._triggerArray = []\n\n const toggleList = SelectorEngine.find(SELECTOR_DATA_TOGGLE)\n\n for (let i = 0, len = toggleList.length; i < len; i++) {\n const elem = toggleList[i]\n const selector = getSelectorFromElement(elem)\n const filterElement = SelectorEngine.find(selector)\n .filter(foundElem => foundElem === this._element)\n\n if (selector !== null && filterElement.length) {\n this._selector = selector\n this._triggerArray.push(elem)\n }\n }\n\n this._initializeChildren()\n\n if (!this._config.parent) {\n this._addAriaAndCollapsedClass(this._triggerArray, this._isShown())\n }\n\n if (this._config.toggle) {\n this.toggle()\n }\n }\n\n // Getters\n\n static get Default() {\n return Default\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n\n toggle() {\n if (this._isShown()) {\n this.hide()\n } else {\n this.show()\n }\n }\n\n show() {\n if (this._isTransitioning || this._isShown()) {\n return\n }\n\n let actives = []\n let activesData\n\n if (this._config.parent) {\n const children = SelectorEngine.find(CLASS_NAME_DEEPER_CHILDREN, this._config.parent)\n actives = SelectorEngine.find(SELECTOR_ACTIVES, this._config.parent).filter(elem => !children.includes(elem)) // remove children if greater depth\n }\n\n const container = SelectorEngine.findOne(this._selector)\n if (actives.length) {\n const tempActiveData = actives.find(elem => container !== elem)\n activesData = tempActiveData ? Collapse.getInstance(tempActiveData) : null\n\n if (activesData && activesData._isTransitioning) {\n return\n }\n }\n\n const startEvent = EventHandler.trigger(this._element, EVENT_SHOW)\n if (startEvent.defaultPrevented) {\n return\n }\n\n actives.forEach(elemActive => {\n if (container !== elemActive) {\n Collapse.getOrCreateInstance(elemActive, { toggle: false }).hide()\n }\n\n if (!activesData) {\n Data.set(elemActive, DATA_KEY, null)\n }\n })\n\n const dimension = this._getDimension()\n\n this._element.classList.remove(CLASS_NAME_COLLAPSE)\n this._element.classList.add(CLASS_NAME_COLLAPSING)\n\n this._element.style[dimension] = 0\n\n this._addAriaAndCollapsedClass(this._triggerArray, true)\n this._isTransitioning = true\n\n const complete = () => {\n this._isTransitioning = false\n\n this._element.classList.remove(CLASS_NAME_COLLAPSING)\n this._element.classList.add(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n this._element.style[dimension] = ''\n\n EventHandler.trigger(this._element, EVENT_SHOWN)\n }\n\n const capitalizedDimension = dimension[0].toUpperCase() + dimension.slice(1)\n const scrollSize = `scroll${capitalizedDimension}`\n\n this._queueCallback(complete, this._element, true)\n this._element.style[dimension] = `${this._element[scrollSize]}px`\n }\n\n hide() {\n if (this._isTransitioning || !this._isShown()) {\n return\n }\n\n const startEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n if (startEvent.defaultPrevented) {\n return\n }\n\n const dimension = this._getDimension()\n\n this._element.style[dimension] = `${this._element.getBoundingClientRect()[dimension]}px`\n\n reflow(this._element)\n\n this._element.classList.add(CLASS_NAME_COLLAPSING)\n this._element.classList.remove(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n const triggerArrayLength = this._triggerArray.length\n for (let i = 0; i < triggerArrayLength; i++) {\n const trigger = this._triggerArray[i]\n const elem = getElementFromSelector(trigger)\n\n if (elem && !this._isShown(elem)) {\n this._addAriaAndCollapsedClass([trigger], false)\n }\n }\n\n this._isTransitioning = true\n\n const complete = () => {\n this._isTransitioning = false\n this._element.classList.remove(CLASS_NAME_COLLAPSING)\n this._element.classList.add(CLASS_NAME_COLLAPSE)\n EventHandler.trigger(this._element, EVENT_HIDDEN)\n }\n\n this._element.style[dimension] = ''\n\n this._queueCallback(complete, this._element, true)\n }\n\n _isShown(element = this._element) {\n return element.classList.contains(CLASS_NAME_SHOW)\n }\n\n // Private\n\n _getConfig(config) {\n config = {\n ...Default,\n ...Manipulator.getDataAttributes(this._element),\n ...config\n }\n config.toggle = Boolean(config.toggle) // Coerce string values\n config.parent = getElement(config.parent)\n typeCheckConfig(NAME, config, DefaultType)\n return config\n }\n\n _getDimension() {\n return this._element.classList.contains(CLASS_NAME_HORIZONTAL) ? WIDTH : HEIGHT\n }\n\n _initializeChildren() {\n if (!this._config.parent) {\n return\n }\n\n const children = SelectorEngine.find(CLASS_NAME_DEEPER_CHILDREN, this._config.parent)\n SelectorEngine.find(SELECTOR_DATA_TOGGLE, this._config.parent).filter(elem => !children.includes(elem))\n .forEach(element => {\n const selected = getElementFromSelector(element)\n\n if (selected) {\n this._addAriaAndCollapsedClass([element], this._isShown(selected))\n }\n })\n }\n\n _addAriaAndCollapsedClass(triggerArray, isOpen) {\n if (!triggerArray.length) {\n return\n }\n\n triggerArray.forEach(elem => {\n if (isOpen) {\n elem.classList.remove(CLASS_NAME_COLLAPSED)\n } else {\n elem.classList.add(CLASS_NAME_COLLAPSED)\n }\n\n elem.setAttribute('aria-expanded', isOpen)\n })\n }\n\n // Static\n\n static jQueryInterface(config) {\n return this.each(function () {\n const _config = {}\n if (typeof config === 'string' && /show|hide/.test(config)) {\n _config.toggle = false\n }\n\n const data = Collapse.getOrCreateInstance(this, _config)\n\n if (typeof config === 'string') {\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n }\n })\n }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n // preventDefault only for elements (which change the URL) not inside the collapsible element\n if (event.target.tagName === 'A' || (event.delegateTarget && event.delegateTarget.tagName === 'A')) {\n event.preventDefault()\n }\n\n const selector = getSelectorFromElement(this)\n const selectorElements = SelectorEngine.find(selector)\n\n selectorElements.forEach(element => {\n Collapse.getOrCreateInstance(element, { toggle: false }).toggle()\n })\n})\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Collapse to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Collapse)\n\nexport default Collapse\n","export var top = 'top';\nexport var bottom = 'bottom';\nexport var right = 'right';\nexport var left = 'left';\nexport var auto = 'auto';\nexport var basePlacements = [top, bottom, right, left];\nexport var start = 'start';\nexport var end = 'end';\nexport var clippingParents = 'clippingParents';\nexport var viewport = 'viewport';\nexport var popper = 'popper';\nexport var reference = 'reference';\nexport var variationPlacements = /*#__PURE__*/basePlacements.reduce(function (acc, placement) {\n return acc.concat([placement + \"-\" + start, placement + \"-\" + end]);\n}, []);\nexport var placements = /*#__PURE__*/[].concat(basePlacements, [auto]).reduce(function (acc, placement) {\n return acc.concat([placement, placement + \"-\" + start, placement + \"-\" + end]);\n}, []); // modifiers that need to read the DOM\n\nexport var beforeRead = 'beforeRead';\nexport var read = 'read';\nexport var afterRead = 'afterRead'; // pure-logic modifiers\n\nexport var beforeMain = 'beforeMain';\nexport var main = 'main';\nexport var afterMain = 'afterMain'; // modifier with the purpose to write to the DOM (or write into a framework state)\n\nexport var beforeWrite = 'beforeWrite';\nexport var write = 'write';\nexport var afterWrite = 'afterWrite';\nexport var modifierPhases = [beforeRead, read, afterRead, beforeMain, main, afterMain, beforeWrite, write, afterWrite];","export default function getNodeName(element) {\n return element ? (element.nodeName || '').toLowerCase() : null;\n}","export default function getWindow(node) {\n if (node == null) {\n return window;\n }\n\n if (node.toString() !== '[object Window]') {\n var ownerDocument = node.ownerDocument;\n return ownerDocument ? ownerDocument.defaultView || window : window;\n }\n\n return node;\n}","import getWindow from \"./getWindow.js\";\n\nfunction isElement(node) {\n var OwnElement = getWindow(node).Element;\n return node instanceof OwnElement || node instanceof Element;\n}\n\nfunction isHTMLElement(node) {\n var OwnElement = getWindow(node).HTMLElement;\n return node instanceof OwnElement || node instanceof HTMLElement;\n}\n\nfunction isShadowRoot(node) {\n // IE 11 has no ShadowRoot\n if (typeof ShadowRoot === 'undefined') {\n return false;\n }\n\n var OwnElement = getWindow(node).ShadowRoot;\n return node instanceof OwnElement || node instanceof ShadowRoot;\n}\n\nexport { isElement, isHTMLElement, isShadowRoot };","import getNodeName from \"../dom-utils/getNodeName.js\";\nimport { isHTMLElement } from \"../dom-utils/instanceOf.js\"; // This modifier takes the styles prepared by the `computeStyles` modifier\n// and applies them to the HTMLElements such as popper and arrow\n\nfunction applyStyles(_ref) {\n var state = _ref.state;\n Object.keys(state.elements).forEach(function (name) {\n var style = state.styles[name] || {};\n var attributes = state.attributes[name] || {};\n var element = state.elements[name]; // arrow is optional + virtual elements\n\n if (!isHTMLElement(element) || !getNodeName(element)) {\n return;\n } // Flow doesn't support to extend this property, but it's the most\n // effective way to apply styles to an HTMLElement\n // $FlowFixMe[cannot-write]\n\n\n Object.assign(element.style, style);\n Object.keys(attributes).forEach(function (name) {\n var value = attributes[name];\n\n if (value === false) {\n element.removeAttribute(name);\n } else {\n element.setAttribute(name, value === true ? '' : value);\n }\n });\n });\n}\n\nfunction effect(_ref2) {\n var state = _ref2.state;\n var initialStyles = {\n popper: {\n position: state.options.strategy,\n left: '0',\n top: '0',\n margin: '0'\n },\n arrow: {\n position: 'absolute'\n },\n reference: {}\n };\n Object.assign(state.elements.popper.style, initialStyles.popper);\n state.styles = initialStyles;\n\n if (state.elements.arrow) {\n Object.assign(state.elements.arrow.style, initialStyles.arrow);\n }\n\n return function () {\n Object.keys(state.elements).forEach(function (name) {\n var element = state.elements[name];\n var attributes = state.attributes[name] || {};\n var styleProperties = Object.keys(state.styles.hasOwnProperty(name) ? state.styles[name] : initialStyles[name]); // Set all values to an empty string to unset them\n\n var style = styleProperties.reduce(function (style, property) {\n style[property] = '';\n return style;\n }, {}); // arrow is optional + virtual elements\n\n if (!isHTMLElement(element) || !getNodeName(element)) {\n return;\n }\n\n Object.assign(element.style, style);\n Object.keys(attributes).forEach(function (attribute) {\n element.removeAttribute(attribute);\n });\n });\n };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'applyStyles',\n enabled: true,\n phase: 'write',\n fn: applyStyles,\n effect: effect,\n requires: ['computeStyles']\n};","import { auto } from \"../enums.js\";\nexport default function getBasePlacement(placement) {\n return placement.split('-')[0];\n}","// import { isHTMLElement } from './instanceOf';\nexport default function getBoundingClientRect(element, // eslint-disable-next-line unused-imports/no-unused-vars\nincludeScale) {\n if (includeScale === void 0) {\n includeScale = false;\n }\n\n var rect = element.getBoundingClientRect();\n var scaleX = 1;\n var scaleY = 1; // FIXME:\n // `offsetWidth` returns an integer while `getBoundingClientRect`\n // returns a float. This results in `scaleX` or `scaleY` being\n // non-1 when it should be for elements that aren't a full pixel in\n // width or height.\n // if (isHTMLElement(element) && includeScale) {\n // const offsetHeight = element.offsetHeight;\n // const offsetWidth = element.offsetWidth;\n // // Do not attempt to divide by 0, otherwise we get `Infinity` as scale\n // // Fallback to 1 in case both values are `0`\n // if (offsetWidth > 0) {\n // scaleX = rect.width / offsetWidth || 1;\n // }\n // if (offsetHeight > 0) {\n // scaleY = rect.height / offsetHeight || 1;\n // }\n // }\n\n return {\n width: rect.width / scaleX,\n height: rect.height / scaleY,\n top: rect.top / scaleY,\n right: rect.right / scaleX,\n bottom: rect.bottom / scaleY,\n left: rect.left / scaleX,\n x: rect.left / scaleX,\n y: rect.top / scaleY\n };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\"; // Returns the layout rect of an element relative to its offsetParent. Layout\n// means it doesn't take into account transforms.\n\nexport default function getLayoutRect(element) {\n var clientRect = getBoundingClientRect(element); // Use the clientRect sizes if it's not been transformed.\n // Fixes https://github.com/popperjs/popper-core/issues/1223\n\n var width = element.offsetWidth;\n var height = element.offsetHeight;\n\n if (Math.abs(clientRect.width - width) <= 1) {\n width = clientRect.width;\n }\n\n if (Math.abs(clientRect.height - height) <= 1) {\n height = clientRect.height;\n }\n\n return {\n x: element.offsetLeft,\n y: element.offsetTop,\n width: width,\n height: height\n };\n}","import { isShadowRoot } from \"./instanceOf.js\";\nexport default function contains(parent, child) {\n var rootNode = child.getRootNode && child.getRootNode(); // First, attempt with faster native method\n\n if (parent.contains(child)) {\n return true;\n } // then fallback to custom implementation with Shadow DOM support\n else if (rootNode && isShadowRoot(rootNode)) {\n var next = child;\n\n do {\n if (next && parent.isSameNode(next)) {\n return true;\n } // $FlowFixMe[prop-missing]: need a better way to handle this...\n\n\n next = next.parentNode || next.host;\n } while (next);\n } // Give up, the result is false\n\n\n return false;\n}","import getWindow from \"./getWindow.js\";\nexport default function getComputedStyle(element) {\n return getWindow(element).getComputedStyle(element);\n}","import getNodeName from \"./getNodeName.js\";\nexport default function isTableElement(element) {\n return ['table', 'td', 'th'].indexOf(getNodeName(element)) >= 0;\n}","import { isElement } from \"./instanceOf.js\";\nexport default function getDocumentElement(element) {\n // $FlowFixMe[incompatible-return]: assume body is always available\n return ((isElement(element) ? element.ownerDocument : // $FlowFixMe[prop-missing]\n element.document) || window.document).documentElement;\n}","import getNodeName from \"./getNodeName.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport { isShadowRoot } from \"./instanceOf.js\";\nexport default function getParentNode(element) {\n if (getNodeName(element) === 'html') {\n return element;\n }\n\n return (// this is a quicker (but less type safe) way to save quite some bytes from the bundle\n // $FlowFixMe[incompatible-return]\n // $FlowFixMe[prop-missing]\n element.assignedSlot || // step into the shadow DOM of the parent of a slotted node\n element.parentNode || ( // DOM Element detected\n isShadowRoot(element) ? element.host : null) || // ShadowRoot detected\n // $FlowFixMe[incompatible-call]: HTMLElement is a Node\n getDocumentElement(element) // fallback\n\n );\n}","import getWindow from \"./getWindow.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport isTableElement from \"./isTableElement.js\";\nimport getParentNode from \"./getParentNode.js\";\n\nfunction getTrueOffsetParent(element) {\n if (!isHTMLElement(element) || // https://github.com/popperjs/popper-core/issues/837\n getComputedStyle(element).position === 'fixed') {\n return null;\n }\n\n return element.offsetParent;\n} // `.offsetParent` reports `null` for fixed elements, while absolute elements\n// return the containing block\n\n\nfunction getContainingBlock(element) {\n var isFirefox = navigator.userAgent.toLowerCase().indexOf('firefox') !== -1;\n var isIE = navigator.userAgent.indexOf('Trident') !== -1;\n\n if (isIE && isHTMLElement(element)) {\n // In IE 9, 10 and 11 fixed elements containing block is always established by the viewport\n var elementCss = getComputedStyle(element);\n\n if (elementCss.position === 'fixed') {\n return null;\n }\n }\n\n var currentNode = getParentNode(element);\n\n while (isHTMLElement(currentNode) && ['html', 'body'].indexOf(getNodeName(currentNode)) < 0) {\n var css = getComputedStyle(currentNode); // This is non-exhaustive but covers the most common CSS properties that\n // create a containing block.\n // https://developer.mozilla.org/en-US/docs/Web/CSS/Containing_block#identifying_the_containing_block\n\n if (css.transform !== 'none' || css.perspective !== 'none' || css.contain === 'paint' || ['transform', 'perspective'].indexOf(css.willChange) !== -1 || isFirefox && css.willChange === 'filter' || isFirefox && css.filter && css.filter !== 'none') {\n return currentNode;\n } else {\n currentNode = currentNode.parentNode;\n }\n }\n\n return null;\n} // Gets the closest ancestor positioned element. Handles some edge cases,\n// such as table ancestors and cross browser bugs.\n\n\nexport default function getOffsetParent(element) {\n var window = getWindow(element);\n var offsetParent = getTrueOffsetParent(element);\n\n while (offsetParent && isTableElement(offsetParent) && getComputedStyle(offsetParent).position === 'static') {\n offsetParent = getTrueOffsetParent(offsetParent);\n }\n\n if (offsetParent && (getNodeName(offsetParent) === 'html' || getNodeName(offsetParent) === 'body' && getComputedStyle(offsetParent).position === 'static')) {\n return window;\n }\n\n return offsetParent || getContainingBlock(element) || window;\n}","export default function getMainAxisFromPlacement(placement) {\n return ['top', 'bottom'].indexOf(placement) >= 0 ? 'x' : 'y';\n}","export var max = Math.max;\nexport var min = Math.min;\nexport var round = Math.round;","import { max as mathMax, min as mathMin } from \"./math.js\";\nexport default function within(min, value, max) {\n return mathMax(min, mathMin(value, max));\n}","import getFreshSideObject from \"./getFreshSideObject.js\";\nexport default function mergePaddingObject(paddingObject) {\n return Object.assign({}, getFreshSideObject(), paddingObject);\n}","export default function getFreshSideObject() {\n return {\n top: 0,\n right: 0,\n bottom: 0,\n left: 0\n };\n}","export default function expandToHashMap(value, keys) {\n return keys.reduce(function (hashMap, key) {\n hashMap[key] = value;\n return hashMap;\n }, {});\n}","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport contains from \"../dom-utils/contains.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport within from \"../utils/within.js\";\nimport mergePaddingObject from \"../utils/mergePaddingObject.js\";\nimport expandToHashMap from \"../utils/expandToHashMap.js\";\nimport { left, right, basePlacements, top, bottom } from \"../enums.js\";\nimport { isHTMLElement } from \"../dom-utils/instanceOf.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar toPaddingObject = function toPaddingObject(padding, state) {\n padding = typeof padding === 'function' ? padding(Object.assign({}, state.rects, {\n placement: state.placement\n })) : padding;\n return mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n};\n\nfunction arrow(_ref) {\n var _state$modifiersData$;\n\n var state = _ref.state,\n name = _ref.name,\n options = _ref.options;\n var arrowElement = state.elements.arrow;\n var popperOffsets = state.modifiersData.popperOffsets;\n var basePlacement = getBasePlacement(state.placement);\n var axis = getMainAxisFromPlacement(basePlacement);\n var isVertical = [left, right].indexOf(basePlacement) >= 0;\n var len = isVertical ? 'height' : 'width';\n\n if (!arrowElement || !popperOffsets) {\n return;\n }\n\n var paddingObject = toPaddingObject(options.padding, state);\n var arrowRect = getLayoutRect(arrowElement);\n var minProp = axis === 'y' ? top : left;\n var maxProp = axis === 'y' ? bottom : right;\n var endDiff = state.rects.reference[len] + state.rects.reference[axis] - popperOffsets[axis] - state.rects.popper[len];\n var startDiff = popperOffsets[axis] - state.rects.reference[axis];\n var arrowOffsetParent = getOffsetParent(arrowElement);\n var clientSize = arrowOffsetParent ? axis === 'y' ? arrowOffsetParent.clientHeight || 0 : arrowOffsetParent.clientWidth || 0 : 0;\n var centerToReference = endDiff / 2 - startDiff / 2; // Make sure the arrow doesn't overflow the popper if the center point is\n // outside of the popper bounds\n\n var min = paddingObject[minProp];\n var max = clientSize - arrowRect[len] - paddingObject[maxProp];\n var center = clientSize / 2 - arrowRect[len] / 2 + centerToReference;\n var offset = within(min, center, max); // Prevents breaking syntax highlighting...\n\n var axisProp = axis;\n state.modifiersData[name] = (_state$modifiersData$ = {}, _state$modifiersData$[axisProp] = offset, _state$modifiersData$.centerOffset = offset - center, _state$modifiersData$);\n}\n\nfunction effect(_ref2) {\n var state = _ref2.state,\n options = _ref2.options;\n var _options$element = options.element,\n arrowElement = _options$element === void 0 ? '[data-popper-arrow]' : _options$element;\n\n if (arrowElement == null) {\n return;\n } // CSS selector\n\n\n if (typeof arrowElement === 'string') {\n arrowElement = state.elements.popper.querySelector(arrowElement);\n\n if (!arrowElement) {\n return;\n }\n }\n\n if (process.env.NODE_ENV !== \"production\") {\n if (!isHTMLElement(arrowElement)) {\n console.error(['Popper: \"arrow\" element must be an HTMLElement (not an SVGElement).', 'To use an SVG arrow, wrap it in an HTMLElement that will be used as', 'the arrow.'].join(' '));\n }\n }\n\n if (!contains(state.elements.popper, arrowElement)) {\n if (process.env.NODE_ENV !== \"production\") {\n console.error(['Popper: \"arrow\" modifier\\'s `element` must be a child of the popper', 'element.'].join(' '));\n }\n\n return;\n }\n\n state.elements.arrow = arrowElement;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'arrow',\n enabled: true,\n phase: 'main',\n fn: arrow,\n effect: effect,\n requires: ['popperOffsets'],\n requiresIfExists: ['preventOverflow']\n};","export default function getVariation(placement) {\n return placement.split('-')[1];\n}","import { top, left, right, bottom, end } from \"../enums.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getWindow from \"../dom-utils/getWindow.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getComputedStyle from \"../dom-utils/getComputedStyle.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport { round } from \"../utils/math.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar unsetSides = {\n top: 'auto',\n right: 'auto',\n bottom: 'auto',\n left: 'auto'\n}; // Round the offsets to the nearest suitable subpixel based on the DPR.\n// Zooming can change the DPR, but it seems to report a value that will\n// cleanly divide the values into the appropriate subpixels.\n\nfunction roundOffsetsByDPR(_ref) {\n var x = _ref.x,\n y = _ref.y;\n var win = window;\n var dpr = win.devicePixelRatio || 1;\n return {\n x: round(round(x * dpr) / dpr) || 0,\n y: round(round(y * dpr) / dpr) || 0\n };\n}\n\nexport function mapToStyles(_ref2) {\n var _Object$assign2;\n\n var popper = _ref2.popper,\n popperRect = _ref2.popperRect,\n placement = _ref2.placement,\n variation = _ref2.variation,\n offsets = _ref2.offsets,\n position = _ref2.position,\n gpuAcceleration = _ref2.gpuAcceleration,\n adaptive = _ref2.adaptive,\n roundOffsets = _ref2.roundOffsets;\n\n var _ref3 = roundOffsets === true ? roundOffsetsByDPR(offsets) : typeof roundOffsets === 'function' ? roundOffsets(offsets) : offsets,\n _ref3$x = _ref3.x,\n x = _ref3$x === void 0 ? 0 : _ref3$x,\n _ref3$y = _ref3.y,\n y = _ref3$y === void 0 ? 0 : _ref3$y;\n\n var hasX = offsets.hasOwnProperty('x');\n var hasY = offsets.hasOwnProperty('y');\n var sideX = left;\n var sideY = top;\n var win = window;\n\n if (adaptive) {\n var offsetParent = getOffsetParent(popper);\n var heightProp = 'clientHeight';\n var widthProp = 'clientWidth';\n\n if (offsetParent === getWindow(popper)) {\n offsetParent = getDocumentElement(popper);\n\n if (getComputedStyle(offsetParent).position !== 'static' && position === 'absolute') {\n heightProp = 'scrollHeight';\n widthProp = 'scrollWidth';\n }\n } // $FlowFixMe[incompatible-cast]: force type refinement, we compare offsetParent with window above, but Flow doesn't detect it\n\n\n offsetParent = offsetParent;\n\n if (placement === top || (placement === left || placement === right) && variation === end) {\n sideY = bottom; // $FlowFixMe[prop-missing]\n\n y -= offsetParent[heightProp] - popperRect.height;\n y *= gpuAcceleration ? 1 : -1;\n }\n\n if (placement === left || (placement === top || placement === bottom) && variation === end) {\n sideX = right; // $FlowFixMe[prop-missing]\n\n x -= offsetParent[widthProp] - popperRect.width;\n x *= gpuAcceleration ? 1 : -1;\n }\n }\n\n var commonStyles = Object.assign({\n position: position\n }, adaptive && unsetSides);\n\n if (gpuAcceleration) {\n var _Object$assign;\n\n return Object.assign({}, commonStyles, (_Object$assign = {}, _Object$assign[sideY] = hasY ? '0' : '', _Object$assign[sideX] = hasX ? '0' : '', _Object$assign.transform = (win.devicePixelRatio || 1) <= 1 ? \"translate(\" + x + \"px, \" + y + \"px)\" : \"translate3d(\" + x + \"px, \" + y + \"px, 0)\", _Object$assign));\n }\n\n return Object.assign({}, commonStyles, (_Object$assign2 = {}, _Object$assign2[sideY] = hasY ? y + \"px\" : '', _Object$assign2[sideX] = hasX ? x + \"px\" : '', _Object$assign2.transform = '', _Object$assign2));\n}\n\nfunction computeStyles(_ref4) {\n var state = _ref4.state,\n options = _ref4.options;\n var _options$gpuAccelerat = options.gpuAcceleration,\n gpuAcceleration = _options$gpuAccelerat === void 0 ? true : _options$gpuAccelerat,\n _options$adaptive = options.adaptive,\n adaptive = _options$adaptive === void 0 ? true : _options$adaptive,\n _options$roundOffsets = options.roundOffsets,\n roundOffsets = _options$roundOffsets === void 0 ? true : _options$roundOffsets;\n\n if (process.env.NODE_ENV !== \"production\") {\n var transitionProperty = getComputedStyle(state.elements.popper).transitionProperty || '';\n\n if (adaptive && ['transform', 'top', 'right', 'bottom', 'left'].some(function (property) {\n return transitionProperty.indexOf(property) >= 0;\n })) {\n console.warn(['Popper: Detected CSS transitions on at least one of the following', 'CSS properties: \"transform\", \"top\", \"right\", \"bottom\", \"left\".', '\\n\\n', 'Disable the \"computeStyles\" modifier\\'s `adaptive` option to allow', 'for smooth transitions, or remove these properties from the CSS', 'transition declaration on the popper element if only transitioning', 'opacity or background-color for example.', '\\n\\n', 'We recommend using the popper element as a wrapper around an inner', 'element that can have any CSS property transitioned for animations.'].join(' '));\n }\n }\n\n var commonStyles = {\n placement: getBasePlacement(state.placement),\n variation: getVariation(state.placement),\n popper: state.elements.popper,\n popperRect: state.rects.popper,\n gpuAcceleration: gpuAcceleration\n };\n\n if (state.modifiersData.popperOffsets != null) {\n state.styles.popper = Object.assign({}, state.styles.popper, mapToStyles(Object.assign({}, commonStyles, {\n offsets: state.modifiersData.popperOffsets,\n position: state.options.strategy,\n adaptive: adaptive,\n roundOffsets: roundOffsets\n })));\n }\n\n if (state.modifiersData.arrow != null) {\n state.styles.arrow = Object.assign({}, state.styles.arrow, mapToStyles(Object.assign({}, commonStyles, {\n offsets: state.modifiersData.arrow,\n position: 'absolute',\n adaptive: false,\n roundOffsets: roundOffsets\n })));\n }\n\n state.attributes.popper = Object.assign({}, state.attributes.popper, {\n 'data-popper-placement': state.placement\n });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'computeStyles',\n enabled: true,\n phase: 'beforeWrite',\n fn: computeStyles,\n data: {}\n};","import getWindow from \"../dom-utils/getWindow.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar passive = {\n passive: true\n};\n\nfunction effect(_ref) {\n var state = _ref.state,\n instance = _ref.instance,\n options = _ref.options;\n var _options$scroll = options.scroll,\n scroll = _options$scroll === void 0 ? true : _options$scroll,\n _options$resize = options.resize,\n resize = _options$resize === void 0 ? true : _options$resize;\n var window = getWindow(state.elements.popper);\n var scrollParents = [].concat(state.scrollParents.reference, state.scrollParents.popper);\n\n if (scroll) {\n scrollParents.forEach(function (scrollParent) {\n scrollParent.addEventListener('scroll', instance.update, passive);\n });\n }\n\n if (resize) {\n window.addEventListener('resize', instance.update, passive);\n }\n\n return function () {\n if (scroll) {\n scrollParents.forEach(function (scrollParent) {\n scrollParent.removeEventListener('scroll', instance.update, passive);\n });\n }\n\n if (resize) {\n window.removeEventListener('resize', instance.update, passive);\n }\n };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'eventListeners',\n enabled: true,\n phase: 'write',\n fn: function fn() {},\n effect: effect,\n data: {}\n};","var hash = {\n left: 'right',\n right: 'left',\n bottom: 'top',\n top: 'bottom'\n};\nexport default function getOppositePlacement(placement) {\n return placement.replace(/left|right|bottom|top/g, function (matched) {\n return hash[matched];\n });\n}","var hash = {\n start: 'end',\n end: 'start'\n};\nexport default function getOppositeVariationPlacement(placement) {\n return placement.replace(/start|end/g, function (matched) {\n return hash[matched];\n });\n}","import getWindow from \"./getWindow.js\";\nexport default function getWindowScroll(node) {\n var win = getWindow(node);\n var scrollLeft = win.pageXOffset;\n var scrollTop = win.pageYOffset;\n return {\n scrollLeft: scrollLeft,\n scrollTop: scrollTop\n };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nexport default function getWindowScrollBarX(element) {\n // If has a CSS width greater than the viewport, then this will be\n // incorrect for RTL.\n // Popper 1 is broken in this case and never had a bug report so let's assume\n // it's not an issue. I don't think anyone ever specifies width on \n // anyway.\n // Browsers where the left scrollbar doesn't cause an issue report `0` for\n // this (e.g. Edge 2019, IE11, Safari)\n return getBoundingClientRect(getDocumentElement(element)).left + getWindowScroll(element).scrollLeft;\n}","import getComputedStyle from \"./getComputedStyle.js\";\nexport default function isScrollParent(element) {\n // Firefox wants us to check `-x` and `-y` variations as well\n var _getComputedStyle = getComputedStyle(element),\n overflow = _getComputedStyle.overflow,\n overflowX = _getComputedStyle.overflowX,\n overflowY = _getComputedStyle.overflowY;\n\n return /auto|scroll|overlay|hidden/.test(overflow + overflowY + overflowX);\n}","import getParentNode from \"./getParentNode.js\";\nimport isScrollParent from \"./isScrollParent.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nexport default function getScrollParent(node) {\n if (['html', 'body', '#document'].indexOf(getNodeName(node)) >= 0) {\n // $FlowFixMe[incompatible-return]: assume body is always available\n return node.ownerDocument.body;\n }\n\n if (isHTMLElement(node) && isScrollParent(node)) {\n return node;\n }\n\n return getScrollParent(getParentNode(node));\n}","import getScrollParent from \"./getScrollParent.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport getWindow from \"./getWindow.js\";\nimport isScrollParent from \"./isScrollParent.js\";\n/*\ngiven a DOM element, return the list of all scroll parents, up the list of ancesors\nuntil we get to the top window object. This list is what we attach scroll listeners\nto, because if any of these parent elements scroll, we'll need to re-calculate the\nreference element's position.\n*/\n\nexport default function listScrollParents(element, list) {\n var _element$ownerDocumen;\n\n if (list === void 0) {\n list = [];\n }\n\n var scrollParent = getScrollParent(element);\n var isBody = scrollParent === ((_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body);\n var win = getWindow(scrollParent);\n var target = isBody ? [win].concat(win.visualViewport || [], isScrollParent(scrollParent) ? scrollParent : []) : scrollParent;\n var updatedList = list.concat(target);\n return isBody ? updatedList : // $FlowFixMe[incompatible-call]: isBody tells us target will be an HTMLElement here\n updatedList.concat(listScrollParents(getParentNode(target)));\n}","export default function rectToClientRect(rect) {\n return Object.assign({}, rect, {\n left: rect.x,\n top: rect.y,\n right: rect.x + rect.width,\n bottom: rect.y + rect.height\n });\n}","import { viewport } from \"../enums.js\";\nimport getViewportRect from \"./getViewportRect.js\";\nimport getDocumentRect from \"./getDocumentRect.js\";\nimport listScrollParents from \"./listScrollParents.js\";\nimport getOffsetParent from \"./getOffsetParent.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isElement, isHTMLElement } from \"./instanceOf.js\";\nimport getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport contains from \"./contains.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport rectToClientRect from \"../utils/rectToClientRect.js\";\nimport { max, min } from \"../utils/math.js\";\n\nfunction getInnerBoundingClientRect(element) {\n var rect = getBoundingClientRect(element);\n rect.top = rect.top + element.clientTop;\n rect.left = rect.left + element.clientLeft;\n rect.bottom = rect.top + element.clientHeight;\n rect.right = rect.left + element.clientWidth;\n rect.width = element.clientWidth;\n rect.height = element.clientHeight;\n rect.x = rect.left;\n rect.y = rect.top;\n return rect;\n}\n\nfunction getClientRectFromMixedType(element, clippingParent) {\n return clippingParent === viewport ? rectToClientRect(getViewportRect(element)) : isHTMLElement(clippingParent) ? getInnerBoundingClientRect(clippingParent) : rectToClientRect(getDocumentRect(getDocumentElement(element)));\n} // A \"clipping parent\" is an overflowable container with the characteristic of\n// clipping (or hiding) overflowing elements with a position different from\n// `initial`\n\n\nfunction getClippingParents(element) {\n var clippingParents = listScrollParents(getParentNode(element));\n var canEscapeClipping = ['absolute', 'fixed'].indexOf(getComputedStyle(element).position) >= 0;\n var clipperElement = canEscapeClipping && isHTMLElement(element) ? getOffsetParent(element) : element;\n\n if (!isElement(clipperElement)) {\n return [];\n } // $FlowFixMe[incompatible-return]: https://github.com/facebook/flow/issues/1414\n\n\n return clippingParents.filter(function (clippingParent) {\n return isElement(clippingParent) && contains(clippingParent, clipperElement) && getNodeName(clippingParent) !== 'body';\n });\n} // Gets the maximum area that the element is visible in due to any number of\n// clipping parents\n\n\nexport default function getClippingRect(element, boundary, rootBoundary) {\n var mainClippingParents = boundary === 'clippingParents' ? getClippingParents(element) : [].concat(boundary);\n var clippingParents = [].concat(mainClippingParents, [rootBoundary]);\n var firstClippingParent = clippingParents[0];\n var clippingRect = clippingParents.reduce(function (accRect, clippingParent) {\n var rect = getClientRectFromMixedType(element, clippingParent);\n accRect.top = max(rect.top, accRect.top);\n accRect.right = min(rect.right, accRect.right);\n accRect.bottom = min(rect.bottom, accRect.bottom);\n accRect.left = max(rect.left, accRect.left);\n return accRect;\n }, getClientRectFromMixedType(element, firstClippingParent));\n clippingRect.width = clippingRect.right - clippingRect.left;\n clippingRect.height = clippingRect.bottom - clippingRect.top;\n clippingRect.x = clippingRect.left;\n clippingRect.y = clippingRect.top;\n return clippingRect;\n}","import getWindow from \"./getWindow.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nexport default function getViewportRect(element) {\n var win = getWindow(element);\n var html = getDocumentElement(element);\n var visualViewport = win.visualViewport;\n var width = html.clientWidth;\n var height = html.clientHeight;\n var x = 0;\n var y = 0; // NB: This isn't supported on iOS <= 12. If the keyboard is open, the popper\n // can be obscured underneath it.\n // Also, `html.clientHeight` adds the bottom bar height in Safari iOS, even\n // if it isn't open, so if this isn't available, the popper will be detected\n // to overflow the bottom of the screen too early.\n\n if (visualViewport) {\n width = visualViewport.width;\n height = visualViewport.height; // Uses Layout Viewport (like Chrome; Safari does not currently)\n // In Chrome, it returns a value very close to 0 (+/-) but contains rounding\n // errors due to floating point numbers, so we need to check precision.\n // Safari returns a number <= 0, usually < -1 when pinch-zoomed\n // Feature detection fails in mobile emulation mode in Chrome.\n // Math.abs(win.innerWidth / visualViewport.scale - visualViewport.width) <\n // 0.001\n // Fallback here: \"Not Safari\" userAgent\n\n if (!/^((?!chrome|android).)*safari/i.test(navigator.userAgent)) {\n x = visualViewport.offsetLeft;\n y = visualViewport.offsetTop;\n }\n }\n\n return {\n width: width,\n height: height,\n x: x + getWindowScrollBarX(element),\n y: y\n };\n}","import getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nimport { max } from \"../utils/math.js\"; // Gets the entire size of the scrollable document area, even extending outside\n// of the `` and `` rect bounds if horizontally scrollable\n\nexport default function getDocumentRect(element) {\n var _element$ownerDocumen;\n\n var html = getDocumentElement(element);\n var winScroll = getWindowScroll(element);\n var body = (_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body;\n var width = max(html.scrollWidth, html.clientWidth, body ? body.scrollWidth : 0, body ? body.clientWidth : 0);\n var height = max(html.scrollHeight, html.clientHeight, body ? body.scrollHeight : 0, body ? body.clientHeight : 0);\n var x = -winScroll.scrollLeft + getWindowScrollBarX(element);\n var y = -winScroll.scrollTop;\n\n if (getComputedStyle(body || html).direction === 'rtl') {\n x += max(html.clientWidth, body ? body.clientWidth : 0) - width;\n }\n\n return {\n width: width,\n height: height,\n x: x,\n y: y\n };\n}","import getBasePlacement from \"./getBasePlacement.js\";\nimport getVariation from \"./getVariation.js\";\nimport getMainAxisFromPlacement from \"./getMainAxisFromPlacement.js\";\nimport { top, right, bottom, left, start, end } from \"../enums.js\";\nexport default function computeOffsets(_ref) {\n var reference = _ref.reference,\n element = _ref.element,\n placement = _ref.placement;\n var basePlacement = placement ? getBasePlacement(placement) : null;\n var variation = placement ? getVariation(placement) : null;\n var commonX = reference.x + reference.width / 2 - element.width / 2;\n var commonY = reference.y + reference.height / 2 - element.height / 2;\n var offsets;\n\n switch (basePlacement) {\n case top:\n offsets = {\n x: commonX,\n y: reference.y - element.height\n };\n break;\n\n case bottom:\n offsets = {\n x: commonX,\n y: reference.y + reference.height\n };\n break;\n\n case right:\n offsets = {\n x: reference.x + reference.width,\n y: commonY\n };\n break;\n\n case left:\n offsets = {\n x: reference.x - element.width,\n y: commonY\n };\n break;\n\n default:\n offsets = {\n x: reference.x,\n y: reference.y\n };\n }\n\n var mainAxis = basePlacement ? getMainAxisFromPlacement(basePlacement) : null;\n\n if (mainAxis != null) {\n var len = mainAxis === 'y' ? 'height' : 'width';\n\n switch (variation) {\n case start:\n offsets[mainAxis] = offsets[mainAxis] - (reference[len] / 2 - element[len] / 2);\n break;\n\n case end:\n offsets[mainAxis] = offsets[mainAxis] + (reference[len] / 2 - element[len] / 2);\n break;\n\n default:\n }\n }\n\n return offsets;\n}","import getClippingRect from \"../dom-utils/getClippingRect.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getBoundingClientRect from \"../dom-utils/getBoundingClientRect.js\";\nimport computeOffsets from \"./computeOffsets.js\";\nimport rectToClientRect from \"./rectToClientRect.js\";\nimport { clippingParents, reference, popper, bottom, top, right, basePlacements, viewport } from \"../enums.js\";\nimport { isElement } from \"../dom-utils/instanceOf.js\";\nimport mergePaddingObject from \"./mergePaddingObject.js\";\nimport expandToHashMap from \"./expandToHashMap.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport default function detectOverflow(state, options) {\n if (options === void 0) {\n options = {};\n }\n\n var _options = options,\n _options$placement = _options.placement,\n placement = _options$placement === void 0 ? state.placement : _options$placement,\n _options$boundary = _options.boundary,\n boundary = _options$boundary === void 0 ? clippingParents : _options$boundary,\n _options$rootBoundary = _options.rootBoundary,\n rootBoundary = _options$rootBoundary === void 0 ? viewport : _options$rootBoundary,\n _options$elementConte = _options.elementContext,\n elementContext = _options$elementConte === void 0 ? popper : _options$elementConte,\n _options$altBoundary = _options.altBoundary,\n altBoundary = _options$altBoundary === void 0 ? false : _options$altBoundary,\n _options$padding = _options.padding,\n padding = _options$padding === void 0 ? 0 : _options$padding;\n var paddingObject = mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n var altContext = elementContext === popper ? reference : popper;\n var popperRect = state.rects.popper;\n var element = state.elements[altBoundary ? altContext : elementContext];\n var clippingClientRect = getClippingRect(isElement(element) ? element : element.contextElement || getDocumentElement(state.elements.popper), boundary, rootBoundary);\n var referenceClientRect = getBoundingClientRect(state.elements.reference);\n var popperOffsets = computeOffsets({\n reference: referenceClientRect,\n element: popperRect,\n strategy: 'absolute',\n placement: placement\n });\n var popperClientRect = rectToClientRect(Object.assign({}, popperRect, popperOffsets));\n var elementClientRect = elementContext === popper ? popperClientRect : referenceClientRect; // positive = overflowing the clipping rect\n // 0 or negative = within the clipping rect\n\n var overflowOffsets = {\n top: clippingClientRect.top - elementClientRect.top + paddingObject.top,\n bottom: elementClientRect.bottom - clippingClientRect.bottom + paddingObject.bottom,\n left: clippingClientRect.left - elementClientRect.left + paddingObject.left,\n right: elementClientRect.right - clippingClientRect.right + paddingObject.right\n };\n var offsetData = state.modifiersData.offset; // Offsets can be applied only to the popper element\n\n if (elementContext === popper && offsetData) {\n var offset = offsetData[placement];\n Object.keys(overflowOffsets).forEach(function (key) {\n var multiply = [right, bottom].indexOf(key) >= 0 ? 1 : -1;\n var axis = [top, bottom].indexOf(key) >= 0 ? 'y' : 'x';\n overflowOffsets[key] += offset[axis] * multiply;\n });\n }\n\n return overflowOffsets;\n}","import getVariation from \"./getVariation.js\";\nimport { variationPlacements, basePlacements, placements as allPlacements } from \"../enums.js\";\nimport detectOverflow from \"./detectOverflow.js\";\nimport getBasePlacement from \"./getBasePlacement.js\";\nexport default function computeAutoPlacement(state, options) {\n if (options === void 0) {\n options = {};\n }\n\n var _options = options,\n placement = _options.placement,\n boundary = _options.boundary,\n rootBoundary = _options.rootBoundary,\n padding = _options.padding,\n flipVariations = _options.flipVariations,\n _options$allowedAutoP = _options.allowedAutoPlacements,\n allowedAutoPlacements = _options$allowedAutoP === void 0 ? allPlacements : _options$allowedAutoP;\n var variation = getVariation(placement);\n var placements = variation ? flipVariations ? variationPlacements : variationPlacements.filter(function (placement) {\n return getVariation(placement) === variation;\n }) : basePlacements;\n var allowedPlacements = placements.filter(function (placement) {\n return allowedAutoPlacements.indexOf(placement) >= 0;\n });\n\n if (allowedPlacements.length === 0) {\n allowedPlacements = placements;\n\n if (process.env.NODE_ENV !== \"production\") {\n console.error(['Popper: The `allowedAutoPlacements` option did not allow any', 'placements. Ensure the `placement` option matches the variation', 'of the allowed placements.', 'For example, \"auto\" cannot be used to allow \"bottom-start\".', 'Use \"auto-start\" instead.'].join(' '));\n }\n } // $FlowFixMe[incompatible-type]: Flow seems to have problems with two array unions...\n\n\n var overflows = allowedPlacements.reduce(function (acc, placement) {\n acc[placement] = detectOverflow(state, {\n placement: placement,\n boundary: boundary,\n rootBoundary: rootBoundary,\n padding: padding\n })[getBasePlacement(placement)];\n return acc;\n }, {});\n return Object.keys(overflows).sort(function (a, b) {\n return overflows[a] - overflows[b];\n });\n}","import getOppositePlacement from \"../utils/getOppositePlacement.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getOppositeVariationPlacement from \"../utils/getOppositeVariationPlacement.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport computeAutoPlacement from \"../utils/computeAutoPlacement.js\";\nimport { bottom, top, start, right, left, auto } from \"../enums.js\";\nimport getVariation from \"../utils/getVariation.js\"; // eslint-disable-next-line import/no-unused-modules\n\nfunction getExpandedFallbackPlacements(placement) {\n if (getBasePlacement(placement) === auto) {\n return [];\n }\n\n var oppositePlacement = getOppositePlacement(placement);\n return [getOppositeVariationPlacement(placement), oppositePlacement, getOppositeVariationPlacement(oppositePlacement)];\n}\n\nfunction flip(_ref) {\n var state = _ref.state,\n options = _ref.options,\n name = _ref.name;\n\n if (state.modifiersData[name]._skip) {\n return;\n }\n\n var _options$mainAxis = options.mainAxis,\n checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n _options$altAxis = options.altAxis,\n checkAltAxis = _options$altAxis === void 0 ? true : _options$altAxis,\n specifiedFallbackPlacements = options.fallbackPlacements,\n padding = options.padding,\n boundary = options.boundary,\n rootBoundary = options.rootBoundary,\n altBoundary = options.altBoundary,\n _options$flipVariatio = options.flipVariations,\n flipVariations = _options$flipVariatio === void 0 ? true : _options$flipVariatio,\n allowedAutoPlacements = options.allowedAutoPlacements;\n var preferredPlacement = state.options.placement;\n var basePlacement = getBasePlacement(preferredPlacement);\n var isBasePlacement = basePlacement === preferredPlacement;\n var fallbackPlacements = specifiedFallbackPlacements || (isBasePlacement || !flipVariations ? [getOppositePlacement(preferredPlacement)] : getExpandedFallbackPlacements(preferredPlacement));\n var placements = [preferredPlacement].concat(fallbackPlacements).reduce(function (acc, placement) {\n return acc.concat(getBasePlacement(placement) === auto ? computeAutoPlacement(state, {\n placement: placement,\n boundary: boundary,\n rootBoundary: rootBoundary,\n padding: padding,\n flipVariations: flipVariations,\n allowedAutoPlacements: allowedAutoPlacements\n }) : placement);\n }, []);\n var referenceRect = state.rects.reference;\n var popperRect = state.rects.popper;\n var checksMap = new Map();\n var makeFallbackChecks = true;\n var firstFittingPlacement = placements[0];\n\n for (var i = 0; i < placements.length; i++) {\n var placement = placements[i];\n\n var _basePlacement = getBasePlacement(placement);\n\n var isStartVariation = getVariation(placement) === start;\n var isVertical = [top, bottom].indexOf(_basePlacement) >= 0;\n var len = isVertical ? 'width' : 'height';\n var overflow = detectOverflow(state, {\n placement: placement,\n boundary: boundary,\n rootBoundary: rootBoundary,\n altBoundary: altBoundary,\n padding: padding\n });\n var mainVariationSide = isVertical ? isStartVariation ? right : left : isStartVariation ? bottom : top;\n\n if (referenceRect[len] > popperRect[len]) {\n mainVariationSide = getOppositePlacement(mainVariationSide);\n }\n\n var altVariationSide = getOppositePlacement(mainVariationSide);\n var checks = [];\n\n if (checkMainAxis) {\n checks.push(overflow[_basePlacement] <= 0);\n }\n\n if (checkAltAxis) {\n checks.push(overflow[mainVariationSide] <= 0, overflow[altVariationSide] <= 0);\n }\n\n if (checks.every(function (check) {\n return check;\n })) {\n firstFittingPlacement = placement;\n makeFallbackChecks = false;\n break;\n }\n\n checksMap.set(placement, checks);\n }\n\n if (makeFallbackChecks) {\n // `2` may be desired in some cases – research later\n var numberOfChecks = flipVariations ? 3 : 1;\n\n var _loop = function _loop(_i) {\n var fittingPlacement = placements.find(function (placement) {\n var checks = checksMap.get(placement);\n\n if (checks) {\n return checks.slice(0, _i).every(function (check) {\n return check;\n });\n }\n });\n\n if (fittingPlacement) {\n firstFittingPlacement = fittingPlacement;\n return \"break\";\n }\n };\n\n for (var _i = numberOfChecks; _i > 0; _i--) {\n var _ret = _loop(_i);\n\n if (_ret === \"break\") break;\n }\n }\n\n if (state.placement !== firstFittingPlacement) {\n state.modifiersData[name]._skip = true;\n state.placement = firstFittingPlacement;\n state.reset = true;\n }\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'flip',\n enabled: true,\n phase: 'main',\n fn: flip,\n requiresIfExists: ['offset'],\n data: {\n _skip: false\n }\n};","import { top, bottom, left, right } from \"../enums.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\n\nfunction getSideOffsets(overflow, rect, preventedOffsets) {\n if (preventedOffsets === void 0) {\n preventedOffsets = {\n x: 0,\n y: 0\n };\n }\n\n return {\n top: overflow.top - rect.height - preventedOffsets.y,\n right: overflow.right - rect.width + preventedOffsets.x,\n bottom: overflow.bottom - rect.height + preventedOffsets.y,\n left: overflow.left - rect.width - preventedOffsets.x\n };\n}\n\nfunction isAnySideFullyClipped(overflow) {\n return [top, right, bottom, left].some(function (side) {\n return overflow[side] >= 0;\n });\n}\n\nfunction hide(_ref) {\n var state = _ref.state,\n name = _ref.name;\n var referenceRect = state.rects.reference;\n var popperRect = state.rects.popper;\n var preventedOffsets = state.modifiersData.preventOverflow;\n var referenceOverflow = detectOverflow(state, {\n elementContext: 'reference'\n });\n var popperAltOverflow = detectOverflow(state, {\n altBoundary: true\n });\n var referenceClippingOffsets = getSideOffsets(referenceOverflow, referenceRect);\n var popperEscapeOffsets = getSideOffsets(popperAltOverflow, popperRect, preventedOffsets);\n var isReferenceHidden = isAnySideFullyClipped(referenceClippingOffsets);\n var hasPopperEscaped = isAnySideFullyClipped(popperEscapeOffsets);\n state.modifiersData[name] = {\n referenceClippingOffsets: referenceClippingOffsets,\n popperEscapeOffsets: popperEscapeOffsets,\n isReferenceHidden: isReferenceHidden,\n hasPopperEscaped: hasPopperEscaped\n };\n state.attributes.popper = Object.assign({}, state.attributes.popper, {\n 'data-popper-reference-hidden': isReferenceHidden,\n 'data-popper-escaped': hasPopperEscaped\n });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'hide',\n enabled: true,\n phase: 'main',\n requiresIfExists: ['preventOverflow'],\n fn: hide\n};","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport { top, left, right, placements } from \"../enums.js\";\nexport function distanceAndSkiddingToXY(placement, rects, offset) {\n var basePlacement = getBasePlacement(placement);\n var invertDistance = [left, top].indexOf(basePlacement) >= 0 ? -1 : 1;\n\n var _ref = typeof offset === 'function' ? offset(Object.assign({}, rects, {\n placement: placement\n })) : offset,\n skidding = _ref[0],\n distance = _ref[1];\n\n skidding = skidding || 0;\n distance = (distance || 0) * invertDistance;\n return [left, right].indexOf(basePlacement) >= 0 ? {\n x: distance,\n y: skidding\n } : {\n x: skidding,\n y: distance\n };\n}\n\nfunction offset(_ref2) {\n var state = _ref2.state,\n options = _ref2.options,\n name = _ref2.name;\n var _options$offset = options.offset,\n offset = _options$offset === void 0 ? [0, 0] : _options$offset;\n var data = placements.reduce(function (acc, placement) {\n acc[placement] = distanceAndSkiddingToXY(placement, state.rects, offset);\n return acc;\n }, {});\n var _data$state$placement = data[state.placement],\n x = _data$state$placement.x,\n y = _data$state$placement.y;\n\n if (state.modifiersData.popperOffsets != null) {\n state.modifiersData.popperOffsets.x += x;\n state.modifiersData.popperOffsets.y += y;\n }\n\n state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'offset',\n enabled: true,\n phase: 'main',\n requires: ['popperOffsets'],\n fn: offset\n};","import computeOffsets from \"../utils/computeOffsets.js\";\n\nfunction popperOffsets(_ref) {\n var state = _ref.state,\n name = _ref.name;\n // Offsets are the actual position the popper needs to have to be\n // properly positioned near its reference element\n // This is the most basic placement, and will be adjusted by\n // the modifiers in the next step\n state.modifiersData[name] = computeOffsets({\n reference: state.rects.reference,\n element: state.rects.popper,\n strategy: 'absolute',\n placement: state.placement\n });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'popperOffsets',\n enabled: true,\n phase: 'read',\n fn: popperOffsets,\n data: {}\n};","import { top, left, right, bottom, start } from \"../enums.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport getAltAxis from \"../utils/getAltAxis.js\";\nimport within from \"../utils/within.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport getFreshSideObject from \"../utils/getFreshSideObject.js\";\nimport { max as mathMax, min as mathMin } from \"../utils/math.js\";\n\nfunction preventOverflow(_ref) {\n var state = _ref.state,\n options = _ref.options,\n name = _ref.name;\n var _options$mainAxis = options.mainAxis,\n checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n _options$altAxis = options.altAxis,\n checkAltAxis = _options$altAxis === void 0 ? false : _options$altAxis,\n boundary = options.boundary,\n rootBoundary = options.rootBoundary,\n altBoundary = options.altBoundary,\n padding = options.padding,\n _options$tether = options.tether,\n tether = _options$tether === void 0 ? true : _options$tether,\n _options$tetherOffset = options.tetherOffset,\n tetherOffset = _options$tetherOffset === void 0 ? 0 : _options$tetherOffset;\n var overflow = detectOverflow(state, {\n boundary: boundary,\n rootBoundary: rootBoundary,\n padding: padding,\n altBoundary: altBoundary\n });\n var basePlacement = getBasePlacement(state.placement);\n var variation = getVariation(state.placement);\n var isBasePlacement = !variation;\n var mainAxis = getMainAxisFromPlacement(basePlacement);\n var altAxis = getAltAxis(mainAxis);\n var popperOffsets = state.modifiersData.popperOffsets;\n var referenceRect = state.rects.reference;\n var popperRect = state.rects.popper;\n var tetherOffsetValue = typeof tetherOffset === 'function' ? tetherOffset(Object.assign({}, state.rects, {\n placement: state.placement\n })) : tetherOffset;\n var data = {\n x: 0,\n y: 0\n };\n\n if (!popperOffsets) {\n return;\n }\n\n if (checkMainAxis || checkAltAxis) {\n var mainSide = mainAxis === 'y' ? top : left;\n var altSide = mainAxis === 'y' ? bottom : right;\n var len = mainAxis === 'y' ? 'height' : 'width';\n var offset = popperOffsets[mainAxis];\n var min = popperOffsets[mainAxis] + overflow[mainSide];\n var max = popperOffsets[mainAxis] - overflow[altSide];\n var additive = tether ? -popperRect[len] / 2 : 0;\n var minLen = variation === start ? referenceRect[len] : popperRect[len];\n var maxLen = variation === start ? -popperRect[len] : -referenceRect[len]; // We need to include the arrow in the calculation so the arrow doesn't go\n // outside the reference bounds\n\n var arrowElement = state.elements.arrow;\n var arrowRect = tether && arrowElement ? getLayoutRect(arrowElement) : {\n width: 0,\n height: 0\n };\n var arrowPaddingObject = state.modifiersData['arrow#persistent'] ? state.modifiersData['arrow#persistent'].padding : getFreshSideObject();\n var arrowPaddingMin = arrowPaddingObject[mainSide];\n var arrowPaddingMax = arrowPaddingObject[altSide]; // If the reference length is smaller than the arrow length, we don't want\n // to include its full size in the calculation. If the reference is small\n // and near the edge of a boundary, the popper can overflow even if the\n // reference is not overflowing as well (e.g. virtual elements with no\n // width or height)\n\n var arrowLen = within(0, referenceRect[len], arrowRect[len]);\n var minOffset = isBasePlacement ? referenceRect[len] / 2 - additive - arrowLen - arrowPaddingMin - tetherOffsetValue : minLen - arrowLen - arrowPaddingMin - tetherOffsetValue;\n var maxOffset = isBasePlacement ? -referenceRect[len] / 2 + additive + arrowLen + arrowPaddingMax + tetherOffsetValue : maxLen + arrowLen + arrowPaddingMax + tetherOffsetValue;\n var arrowOffsetParent = state.elements.arrow && getOffsetParent(state.elements.arrow);\n var clientOffset = arrowOffsetParent ? mainAxis === 'y' ? arrowOffsetParent.clientTop || 0 : arrowOffsetParent.clientLeft || 0 : 0;\n var offsetModifierValue = state.modifiersData.offset ? state.modifiersData.offset[state.placement][mainAxis] : 0;\n var tetherMin = popperOffsets[mainAxis] + minOffset - offsetModifierValue - clientOffset;\n var tetherMax = popperOffsets[mainAxis] + maxOffset - offsetModifierValue;\n\n if (checkMainAxis) {\n var preventedOffset = within(tether ? mathMin(min, tetherMin) : min, offset, tether ? mathMax(max, tetherMax) : max);\n popperOffsets[mainAxis] = preventedOffset;\n data[mainAxis] = preventedOffset - offset;\n }\n\n if (checkAltAxis) {\n var _mainSide = mainAxis === 'x' ? top : left;\n\n var _altSide = mainAxis === 'x' ? bottom : right;\n\n var _offset = popperOffsets[altAxis];\n\n var _min = _offset + overflow[_mainSide];\n\n var _max = _offset - overflow[_altSide];\n\n var _preventedOffset = within(tether ? mathMin(_min, tetherMin) : _min, _offset, tether ? mathMax(_max, tetherMax) : _max);\n\n popperOffsets[altAxis] = _preventedOffset;\n data[altAxis] = _preventedOffset - _offset;\n }\n }\n\n state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n name: 'preventOverflow',\n enabled: true,\n phase: 'main',\n fn: preventOverflow,\n requiresIfExists: ['offset']\n};","export default function getAltAxis(axis) {\n return axis === 'x' ? 'y' : 'x';\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getNodeScroll from \"./getNodeScroll.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport isScrollParent from \"./isScrollParent.js\";\n\nfunction isElementScaled(element) {\n var rect = element.getBoundingClientRect();\n var scaleX = rect.width / element.offsetWidth || 1;\n var scaleY = rect.height / element.offsetHeight || 1;\n return scaleX !== 1 || scaleY !== 1;\n} // Returns the composite rect of an element relative to its offsetParent.\n// Composite means it takes into account transforms as well as layout.\n\n\nexport default function getCompositeRect(elementOrVirtualElement, offsetParent, isFixed) {\n if (isFixed === void 0) {\n isFixed = false;\n }\n\n var isOffsetParentAnElement = isHTMLElement(offsetParent);\n var offsetParentIsScaled = isHTMLElement(offsetParent) && isElementScaled(offsetParent);\n var documentElement = getDocumentElement(offsetParent);\n var rect = getBoundingClientRect(elementOrVirtualElement, offsetParentIsScaled);\n var scroll = {\n scrollLeft: 0,\n scrollTop: 0\n };\n var offsets = {\n x: 0,\n y: 0\n };\n\n if (isOffsetParentAnElement || !isOffsetParentAnElement && !isFixed) {\n if (getNodeName(offsetParent) !== 'body' || // https://github.com/popperjs/popper-core/issues/1078\n isScrollParent(documentElement)) {\n scroll = getNodeScroll(offsetParent);\n }\n\n if (isHTMLElement(offsetParent)) {\n offsets = getBoundingClientRect(offsetParent, true);\n offsets.x += offsetParent.clientLeft;\n offsets.y += offsetParent.clientTop;\n } else if (documentElement) {\n offsets.x = getWindowScrollBarX(documentElement);\n }\n }\n\n return {\n x: rect.left + scroll.scrollLeft - offsets.x,\n y: rect.top + scroll.scrollTop - offsets.y,\n width: rect.width,\n height: rect.height\n };\n}","import getWindowScroll from \"./getWindowScroll.js\";\nimport getWindow from \"./getWindow.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getHTMLElementScroll from \"./getHTMLElementScroll.js\";\nexport default function getNodeScroll(node) {\n if (node === getWindow(node) || !isHTMLElement(node)) {\n return getWindowScroll(node);\n } else {\n return getHTMLElementScroll(node);\n }\n}","export default function getHTMLElementScroll(element) {\n return {\n scrollLeft: element.scrollLeft,\n scrollTop: element.scrollTop\n };\n}","import { modifierPhases } from \"../enums.js\"; // source: https://stackoverflow.com/questions/49875255\n\nfunction order(modifiers) {\n var map = new Map();\n var visited = new Set();\n var result = [];\n modifiers.forEach(function (modifier) {\n map.set(modifier.name, modifier);\n }); // On visiting object, check for its dependencies and visit them recursively\n\n function sort(modifier) {\n visited.add(modifier.name);\n var requires = [].concat(modifier.requires || [], modifier.requiresIfExists || []);\n requires.forEach(function (dep) {\n if (!visited.has(dep)) {\n var depModifier = map.get(dep);\n\n if (depModifier) {\n sort(depModifier);\n }\n }\n });\n result.push(modifier);\n }\n\n modifiers.forEach(function (modifier) {\n if (!visited.has(modifier.name)) {\n // check for visited object\n sort(modifier);\n }\n });\n return result;\n}\n\nexport default function orderModifiers(modifiers) {\n // order based on dependencies\n var orderedModifiers = order(modifiers); // order based on phase\n\n return modifierPhases.reduce(function (acc, phase) {\n return acc.concat(orderedModifiers.filter(function (modifier) {\n return modifier.phase === phase;\n }));\n }, []);\n}","import getCompositeRect from \"./dom-utils/getCompositeRect.js\";\nimport getLayoutRect from \"./dom-utils/getLayoutRect.js\";\nimport listScrollParents from \"./dom-utils/listScrollParents.js\";\nimport getOffsetParent from \"./dom-utils/getOffsetParent.js\";\nimport getComputedStyle from \"./dom-utils/getComputedStyle.js\";\nimport orderModifiers from \"./utils/orderModifiers.js\";\nimport debounce from \"./utils/debounce.js\";\nimport validateModifiers from \"./utils/validateModifiers.js\";\nimport uniqueBy from \"./utils/uniqueBy.js\";\nimport getBasePlacement from \"./utils/getBasePlacement.js\";\nimport mergeByName from \"./utils/mergeByName.js\";\nimport detectOverflow from \"./utils/detectOverflow.js\";\nimport { isElement } from \"./dom-utils/instanceOf.js\";\nimport { auto } from \"./enums.js\";\nvar INVALID_ELEMENT_ERROR = 'Popper: Invalid reference or popper argument provided. They must be either a DOM element or virtual element.';\nvar INFINITE_LOOP_ERROR = 'Popper: An infinite loop in the modifiers cycle has been detected! The cycle has been interrupted to prevent a browser crash.';\nvar DEFAULT_OPTIONS = {\n placement: 'bottom',\n modifiers: [],\n strategy: 'absolute'\n};\n\nfunction areValidElements() {\n for (var _len = arguments.length, args = new Array(_len), _key = 0; _key < _len; _key++) {\n args[_key] = arguments[_key];\n }\n\n return !args.some(function (element) {\n return !(element && typeof element.getBoundingClientRect === 'function');\n });\n}\n\nexport function popperGenerator(generatorOptions) {\n if (generatorOptions === void 0) {\n generatorOptions = {};\n }\n\n var _generatorOptions = generatorOptions,\n _generatorOptions$def = _generatorOptions.defaultModifiers,\n defaultModifiers = _generatorOptions$def === void 0 ? [] : _generatorOptions$def,\n _generatorOptions$def2 = _generatorOptions.defaultOptions,\n defaultOptions = _generatorOptions$def2 === void 0 ? DEFAULT_OPTIONS : _generatorOptions$def2;\n return function createPopper(reference, popper, options) {\n if (options === void 0) {\n options = defaultOptions;\n }\n\n var state = {\n placement: 'bottom',\n orderedModifiers: [],\n options: Object.assign({}, DEFAULT_OPTIONS, defaultOptions),\n modifiersData: {},\n elements: {\n reference: reference,\n popper: popper\n },\n attributes: {},\n styles: {}\n };\n var effectCleanupFns = [];\n var isDestroyed = false;\n var instance = {\n state: state,\n setOptions: function setOptions(setOptionsAction) {\n var options = typeof setOptionsAction === 'function' ? setOptionsAction(state.options) : setOptionsAction;\n cleanupModifierEffects();\n state.options = Object.assign({}, defaultOptions, state.options, options);\n state.scrollParents = {\n reference: isElement(reference) ? listScrollParents(reference) : reference.contextElement ? listScrollParents(reference.contextElement) : [],\n popper: listScrollParents(popper)\n }; // Orders the modifiers based on their dependencies and `phase`\n // properties\n\n var orderedModifiers = orderModifiers(mergeByName([].concat(defaultModifiers, state.options.modifiers))); // Strip out disabled modifiers\n\n state.orderedModifiers = orderedModifiers.filter(function (m) {\n return m.enabled;\n }); // Validate the provided modifiers so that the consumer will get warned\n // if one of the modifiers is invalid for any reason\n\n if (process.env.NODE_ENV !== \"production\") {\n var modifiers = uniqueBy([].concat(orderedModifiers, state.options.modifiers), function (_ref) {\n var name = _ref.name;\n return name;\n });\n validateModifiers(modifiers);\n\n if (getBasePlacement(state.options.placement) === auto) {\n var flipModifier = state.orderedModifiers.find(function (_ref2) {\n var name = _ref2.name;\n return name === 'flip';\n });\n\n if (!flipModifier) {\n console.error(['Popper: \"auto\" placements require the \"flip\" modifier be', 'present and enabled to work.'].join(' '));\n }\n }\n\n var _getComputedStyle = getComputedStyle(popper),\n marginTop = _getComputedStyle.marginTop,\n marginRight = _getComputedStyle.marginRight,\n marginBottom = _getComputedStyle.marginBottom,\n marginLeft = _getComputedStyle.marginLeft; // We no longer take into account `margins` on the popper, and it can\n // cause bugs with positioning, so we'll warn the consumer\n\n\n if ([marginTop, marginRight, marginBottom, marginLeft].some(function (margin) {\n return parseFloat(margin);\n })) {\n console.warn(['Popper: CSS \"margin\" styles cannot be used to apply padding', 'between the popper and its reference element or boundary.', 'To replicate margin, use the `offset` modifier, as well as', 'the `padding` option in the `preventOverflow` and `flip`', 'modifiers.'].join(' '));\n }\n }\n\n runModifierEffects();\n return instance.update();\n },\n // Sync update – it will always be executed, even if not necessary. This\n // is useful for low frequency updates where sync behavior simplifies the\n // logic.\n // For high frequency updates (e.g. `resize` and `scroll` events), always\n // prefer the async Popper#update method\n forceUpdate: function forceUpdate() {\n if (isDestroyed) {\n return;\n }\n\n var _state$elements = state.elements,\n reference = _state$elements.reference,\n popper = _state$elements.popper; // Don't proceed if `reference` or `popper` are not valid elements\n // anymore\n\n if (!areValidElements(reference, popper)) {\n if (process.env.NODE_ENV !== \"production\") {\n console.error(INVALID_ELEMENT_ERROR);\n }\n\n return;\n } // Store the reference and popper rects to be read by modifiers\n\n\n state.rects = {\n reference: getCompositeRect(reference, getOffsetParent(popper), state.options.strategy === 'fixed'),\n popper: getLayoutRect(popper)\n }; // Modifiers have the ability to reset the current update cycle. The\n // most common use case for this is the `flip` modifier changing the\n // placement, which then needs to re-run all the modifiers, because the\n // logic was previously ran for the previous placement and is therefore\n // stale/incorrect\n\n state.reset = false;\n state.placement = state.options.placement; // On each update cycle, the `modifiersData` property for each modifier\n // is filled with the initial data specified by the modifier. This means\n // it doesn't persist and is fresh on each update.\n // To ensure persistent data, use `${name}#persistent`\n\n state.orderedModifiers.forEach(function (modifier) {\n return state.modifiersData[modifier.name] = Object.assign({}, modifier.data);\n });\n var __debug_loops__ = 0;\n\n for (var index = 0; index < state.orderedModifiers.length; index++) {\n if (process.env.NODE_ENV !== \"production\") {\n __debug_loops__ += 1;\n\n if (__debug_loops__ > 100) {\n console.error(INFINITE_LOOP_ERROR);\n break;\n }\n }\n\n if (state.reset === true) {\n state.reset = false;\n index = -1;\n continue;\n }\n\n var _state$orderedModifie = state.orderedModifiers[index],\n fn = _state$orderedModifie.fn,\n _state$orderedModifie2 = _state$orderedModifie.options,\n _options = _state$orderedModifie2 === void 0 ? {} : _state$orderedModifie2,\n name = _state$orderedModifie.name;\n\n if (typeof fn === 'function') {\n state = fn({\n state: state,\n options: _options,\n name: name,\n instance: instance\n }) || state;\n }\n }\n },\n // Async and optimistically optimized update – it will not be executed if\n // not necessary (debounced to run at most once-per-tick)\n update: debounce(function () {\n return new Promise(function (resolve) {\n instance.forceUpdate();\n resolve(state);\n });\n }),\n destroy: function destroy() {\n cleanupModifierEffects();\n isDestroyed = true;\n }\n };\n\n if (!areValidElements(reference, popper)) {\n if (process.env.NODE_ENV !== \"production\") {\n console.error(INVALID_ELEMENT_ERROR);\n }\n\n return instance;\n }\n\n instance.setOptions(options).then(function (state) {\n if (!isDestroyed && options.onFirstUpdate) {\n options.onFirstUpdate(state);\n }\n }); // Modifiers have the ability to execute arbitrary code before the first\n // update cycle runs. They will be executed in the same order as the update\n // cycle. This is useful when a modifier adds some persistent data that\n // other modifiers need to use, but the modifier is run after the dependent\n // one.\n\n function runModifierEffects() {\n state.orderedModifiers.forEach(function (_ref3) {\n var name = _ref3.name,\n _ref3$options = _ref3.options,\n options = _ref3$options === void 0 ? {} : _ref3$options,\n effect = _ref3.effect;\n\n if (typeof effect === 'function') {\n var cleanupFn = effect({\n state: state,\n name: name,\n instance: instance,\n options: options\n });\n\n var noopFn = function noopFn() {};\n\n effectCleanupFns.push(cleanupFn || noopFn);\n }\n });\n }\n\n function cleanupModifierEffects() {\n effectCleanupFns.forEach(function (fn) {\n return fn();\n });\n effectCleanupFns = [];\n }\n\n return instance;\n };\n}\nexport var createPopper = /*#__PURE__*/popperGenerator(); // eslint-disable-next-line import/no-unused-modules\n\nexport { detectOverflow };","export default function debounce(fn) {\n var pending;\n return function () {\n if (!pending) {\n pending = new Promise(function (resolve) {\n Promise.resolve().then(function () {\n pending = undefined;\n resolve(fn());\n });\n });\n }\n\n return pending;\n };\n}","export default function mergeByName(modifiers) {\n var merged = modifiers.reduce(function (merged, current) {\n var existing = merged[current.name];\n merged[current.name] = existing ? Object.assign({}, existing, current, {\n options: Object.assign({}, existing.options, current.options),\n data: Object.assign({}, existing.data, current.data)\n }) : current;\n return merged;\n }, {}); // IE11 does not support Object.values\n\n return Object.keys(merged).map(function (key) {\n return merged[key];\n });\n}","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles];\nvar createPopper = /*#__PURE__*/popperGenerator({\n defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow };","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nimport offset from \"./modifiers/offset.js\";\nimport flip from \"./modifiers/flip.js\";\nimport preventOverflow from \"./modifiers/preventOverflow.js\";\nimport arrow from \"./modifiers/arrow.js\";\nimport hide from \"./modifiers/hide.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles, offset, flip, preventOverflow, arrow, hide];\nvar createPopper = /*#__PURE__*/popperGenerator({\n defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow }; // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper as createPopperLite } from \"./popper-lite.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport * from \"./modifiers/index.js\";","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): dropdown.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\n\nimport {\n defineJQueryPlugin,\n getElement,\n getElementFromSelector,\n getNextActiveElement,\n isDisabled,\n isElement,\n isRTL,\n isVisible,\n noop,\n typeCheckConfig\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'dropdown'\nconst DATA_KEY = 'bs.dropdown'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ESCAPE_KEY = 'Escape'\nconst SPACE_KEY = 'Space'\nconst TAB_KEY = 'Tab'\nconst ARROW_UP_KEY = 'ArrowUp'\nconst ARROW_DOWN_KEY = 'ArrowDown'\nconst RIGHT_MOUSE_BUTTON = 2 // MouseEvent.button value for the secondary button, usually the right button\n\nconst REGEXP_KEYDOWN = new RegExp(`${ARROW_UP_KEY}|${ARROW_DOWN_KEY}|${ESCAPE_KEY}`)\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DATA_API = `keydown${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYUP_DATA_API = `keyup${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_DROPUP = 'dropup'\nconst CLASS_NAME_DROPEND = 'dropend'\nconst CLASS_NAME_DROPSTART = 'dropstart'\nconst CLASS_NAME_NAVBAR = 'navbar'\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"dropdown\"]'\nconst SELECTOR_MENU = '.dropdown-menu'\nconst SELECTOR_NAVBAR_NAV = '.navbar-nav'\nconst SELECTOR_VISIBLE_ITEMS = '.dropdown-menu .dropdown-item:not(.disabled):not(:disabled)'\n\nconst PLACEMENT_TOP = isRTL() ? 'top-end' : 'top-start'\nconst PLACEMENT_TOPEND = isRTL() ? 'top-start' : 'top-end'\nconst PLACEMENT_BOTTOM = isRTL() ? 'bottom-end' : 'bottom-start'\nconst PLACEMENT_BOTTOMEND = isRTL() ? 'bottom-start' : 'bottom-end'\nconst PLACEMENT_RIGHT = isRTL() ? 'left-start' : 'right-start'\nconst PLACEMENT_LEFT = isRTL() ? 'right-start' : 'left-start'\n\nconst Default = {\n offset: [0, 2],\n boundary: 'clippingParents',\n reference: 'toggle',\n display: 'dynamic',\n popperConfig: null,\n autoClose: true\n}\n\nconst DefaultType = {\n offset: '(array|string|function)',\n boundary: '(string|element)',\n reference: '(string|element|object)',\n display: 'string',\n popperConfig: '(null|object|function)',\n autoClose: '(boolean|string)'\n}\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Dropdown extends BaseComponent {\n constructor(element, config) {\n super(element)\n\n this._popper = null\n this._config = this._getConfig(config)\n this._menu = this._getMenuElement()\n this._inNavbar = this._detectNavbar()\n }\n\n // Getters\n\n static get Default() {\n return Default\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n\n toggle() {\n return this._isShown() ? this.hide() : this.show()\n }\n\n show() {\n if (isDisabled(this._element) || this._isShown(this._menu)) {\n return\n }\n\n const relatedTarget = {\n relatedTarget: this._element\n }\n\n const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, relatedTarget)\n\n if (showEvent.defaultPrevented) {\n return\n }\n\n const parent = Dropdown.getParentFromElement(this._element)\n // Totally disable Popper for Dropdowns in Navbar\n if (this._inNavbar) {\n Manipulator.setDataAttribute(this._menu, 'popper', 'none')\n } else {\n this._createPopper(parent)\n }\n\n // If this is a touch-enabled device we add extra\n // empty mouseover listeners to the body's immediate children;\n // only needed because of broken event delegation on iOS\n // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n if ('ontouchstart' in document.documentElement &&\n !parent.closest(SELECTOR_NAVBAR_NAV)) {\n [].concat(...document.body.children)\n .forEach(elem => EventHandler.on(elem, 'mouseover', noop))\n }\n\n this._element.focus()\n this._element.setAttribute('aria-expanded', true)\n\n this._menu.classList.add(CLASS_NAME_SHOW)\n this._element.classList.add(CLASS_NAME_SHOW)\n EventHandler.trigger(this._element, EVENT_SHOWN, relatedTarget)\n }\n\n hide() {\n if (isDisabled(this._element) || !this._isShown(this._menu)) {\n return\n }\n\n const relatedTarget = {\n relatedTarget: this._element\n }\n\n this._completeHide(relatedTarget)\n }\n\n dispose() {\n if (this._popper) {\n this._popper.destroy()\n }\n\n super.dispose()\n }\n\n update() {\n this._inNavbar = this._detectNavbar()\n if (this._popper) {\n this._popper.update()\n }\n }\n\n // Private\n\n _completeHide(relatedTarget) {\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE, relatedTarget)\n if (hideEvent.defaultPrevented) {\n return\n }\n\n // If this is a touch-enabled device we remove the extra\n // empty mouseover listeners we added for iOS support\n if ('ontouchstart' in document.documentElement) {\n [].concat(...document.body.children)\n .forEach(elem => EventHandler.off(elem, 'mouseover', noop))\n }\n\n if (this._popper) {\n this._popper.destroy()\n }\n\n this._menu.classList.remove(CLASS_NAME_SHOW)\n this._element.classList.remove(CLASS_NAME_SHOW)\n this._element.setAttribute('aria-expanded', 'false')\n Manipulator.removeDataAttribute(this._menu, 'popper')\n EventHandler.trigger(this._element, EVENT_HIDDEN, relatedTarget)\n }\n\n _getConfig(config) {\n config = {\n ...this.constructor.Default,\n ...Manipulator.getDataAttributes(this._element),\n ...config\n }\n\n typeCheckConfig(NAME, config, this.constructor.DefaultType)\n\n if (typeof config.reference === 'object' && !isElement(config.reference) &&\n typeof config.reference.getBoundingClientRect !== 'function'\n ) {\n // Popper virtual elements require a getBoundingClientRect method\n throw new TypeError(`${NAME.toUpperCase()}: Option \"reference\" provided type \"object\" without a required \"getBoundingClientRect\" method.`)\n }\n\n return config\n }\n\n _createPopper(parent) {\n if (typeof Popper === 'undefined') {\n throw new TypeError('Bootstrap\\'s dropdowns require Popper (https://popper.js.org)')\n }\n\n let referenceElement = this._element\n\n if (this._config.reference === 'parent') {\n referenceElement = parent\n } else if (isElement(this._config.reference)) {\n referenceElement = getElement(this._config.reference)\n } else if (typeof this._config.reference === 'object') {\n referenceElement = this._config.reference\n }\n\n const popperConfig = this._getPopperConfig()\n const isDisplayStatic = popperConfig.modifiers.find(modifier => modifier.name === 'applyStyles' && modifier.enabled === false)\n\n this._popper = Popper.createPopper(referenceElement, this._menu, popperConfig)\n\n if (isDisplayStatic) {\n Manipulator.setDataAttribute(this._menu, 'popper', 'static')\n }\n }\n\n _isShown(element = this._element) {\n return element.classList.contains(CLASS_NAME_SHOW)\n }\n\n _getMenuElement() {\n return SelectorEngine.next(this._element, SELECTOR_MENU)[0]\n }\n\n _getPlacement() {\n const parentDropdown = this._element.parentNode\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPEND)) {\n return PLACEMENT_RIGHT\n }\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPSTART)) {\n return PLACEMENT_LEFT\n }\n\n // We need to trim the value because custom properties can also include spaces\n const isEnd = getComputedStyle(this._menu).getPropertyValue('--bs-position').trim() === 'end'\n\n if (parentDropdown.classList.contains(CLASS_NAME_DROPUP)) {\n return isEnd ? PLACEMENT_TOPEND : PLACEMENT_TOP\n }\n\n return isEnd ? PLACEMENT_BOTTOMEND : PLACEMENT_BOTTOM\n }\n\n _detectNavbar() {\n return this._element.closest(`.${CLASS_NAME_NAVBAR}`) !== null\n }\n\n _getOffset() {\n const { offset } = this._config\n\n if (typeof offset === 'string') {\n return offset.split(',').map(val => Number.parseInt(val, 10))\n }\n\n if (typeof offset === 'function') {\n return popperData => offset(popperData, this._element)\n }\n\n return offset\n }\n\n _getPopperConfig() {\n const defaultBsPopperConfig = {\n placement: this._getPlacement(),\n modifiers: [{\n name: 'preventOverflow',\n options: {\n boundary: this._config.boundary\n }\n },\n {\n name: 'offset',\n options: {\n offset: this._getOffset()\n }\n }]\n }\n\n // Disable Popper if we have a static display\n if (this._config.display === 'static') {\n defaultBsPopperConfig.modifiers = [{\n name: 'applyStyles',\n enabled: false\n }]\n }\n\n return {\n ...defaultBsPopperConfig,\n ...(typeof this._config.popperConfig === 'function' ? this._config.popperConfig(defaultBsPopperConfig) : this._config.popperConfig)\n }\n }\n\n _selectMenuItem({ key, target }) {\n const items = SelectorEngine.find(SELECTOR_VISIBLE_ITEMS, this._menu).filter(isVisible)\n\n if (!items.length) {\n return\n }\n\n // if target isn't included in items (e.g. when expanding the dropdown)\n // allow cycling to get the last item in case key equals ARROW_UP_KEY\n getNextActiveElement(items, target, key === ARROW_DOWN_KEY, !items.includes(target)).focus()\n }\n\n // Static\n\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Dropdown.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n })\n }\n\n static clearMenus(event) {\n if (event && (event.button === RIGHT_MOUSE_BUTTON || (event.type === 'keyup' && event.key !== TAB_KEY))) {\n return\n }\n\n const toggles = SelectorEngine.find(SELECTOR_DATA_TOGGLE)\n\n for (let i = 0, len = toggles.length; i < len; i++) {\n const context = Dropdown.getInstance(toggles[i])\n if (!context || context._config.autoClose === false) {\n continue\n }\n\n if (!context._isShown()) {\n continue\n }\n\n const relatedTarget = {\n relatedTarget: context._element\n }\n\n if (event) {\n const composedPath = event.composedPath()\n const isMenuTarget = composedPath.includes(context._menu)\n if (\n composedPath.includes(context._element) ||\n (context._config.autoClose === 'inside' && !isMenuTarget) ||\n (context._config.autoClose === 'outside' && isMenuTarget)\n ) {\n continue\n }\n\n // Tab navigation through the dropdown menu or events from contained inputs shouldn't close the menu\n if (context._menu.contains(event.target) && ((event.type === 'keyup' && event.key === TAB_KEY) || /input|select|option|textarea|form/i.test(event.target.tagName))) {\n continue\n }\n\n if (event.type === 'click') {\n relatedTarget.clickEvent = event\n }\n }\n\n context._completeHide(relatedTarget)\n }\n }\n\n static getParentFromElement(element) {\n return getElementFromSelector(element) || element.parentNode\n }\n\n static dataApiKeydownHandler(event) {\n // If not input/textarea:\n // - And not a key in REGEXP_KEYDOWN => not a dropdown command\n // If input/textarea:\n // - If space key => not a dropdown command\n // - If key is other than escape\n // - If key is not up or down => not a dropdown command\n // - If trigger inside the menu => not a dropdown command\n if (/input|textarea/i.test(event.target.tagName) ?\n event.key === SPACE_KEY || (event.key !== ESCAPE_KEY &&\n ((event.key !== ARROW_DOWN_KEY && event.key !== ARROW_UP_KEY) ||\n event.target.closest(SELECTOR_MENU))) :\n !REGEXP_KEYDOWN.test(event.key)) {\n return\n }\n\n const isActive = this.classList.contains(CLASS_NAME_SHOW)\n\n if (!isActive && event.key === ESCAPE_KEY) {\n return\n }\n\n event.preventDefault()\n event.stopPropagation()\n\n if (isDisabled(this)) {\n return\n }\n\n const getToggleButton = this.matches(SELECTOR_DATA_TOGGLE) ? this : SelectorEngine.prev(this, SELECTOR_DATA_TOGGLE)[0]\n const instance = Dropdown.getOrCreateInstance(getToggleButton)\n\n if (event.key === ESCAPE_KEY) {\n instance.hide()\n return\n }\n\n if (event.key === ARROW_UP_KEY || event.key === ARROW_DOWN_KEY) {\n if (!isActive) {\n instance.show()\n }\n\n instance._selectMenuItem(event)\n return\n }\n\n if (!isActive || event.key === SPACE_KEY) {\n Dropdown.clearMenus()\n }\n }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_DATA_TOGGLE, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_MENU, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_CLICK_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_KEYUP_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n event.preventDefault()\n Dropdown.getOrCreateInstance(this).toggle()\n})\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Dropdown to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Dropdown)\n\nexport default Dropdown\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): util/scrollBar.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport SelectorEngine from '../dom/selector-engine'\nimport Manipulator from '../dom/manipulator'\nimport { isElement } from './index'\n\nconst SELECTOR_FIXED_CONTENT = '.fixed-top, .fixed-bottom, .is-fixed, .sticky-top'\nconst SELECTOR_STICKY_CONTENT = '.sticky-top'\n\nclass ScrollBarHelper {\n constructor() {\n this._element = document.body\n }\n\n getWidth() {\n // https://developer.mozilla.org/en-US/docs/Web/API/Window/innerWidth#usage_notes\n const documentWidth = document.documentElement.clientWidth\n return Math.abs(window.innerWidth - documentWidth)\n }\n\n hide() {\n const width = this.getWidth()\n this._disableOverFlow()\n // give padding to element to balance the hidden scrollbar width\n this._setElementAttributes(this._element, 'paddingRight', calculatedValue => calculatedValue + width)\n // trick: We adjust positive paddingRight and negative marginRight to sticky-top elements to keep showing fullwidth\n this._setElementAttributes(SELECTOR_FIXED_CONTENT, 'paddingRight', calculatedValue => calculatedValue + width)\n this._setElementAttributes(SELECTOR_STICKY_CONTENT, 'marginRight', calculatedValue => calculatedValue - width)\n }\n\n _disableOverFlow() {\n this._saveInitialAttribute(this._element, 'overflow')\n this._element.style.overflow = 'hidden'\n }\n\n _setElementAttributes(selector, styleProp, callback) {\n const scrollbarWidth = this.getWidth()\n const manipulationCallBack = element => {\n if (element !== this._element && window.innerWidth > element.clientWidth + scrollbarWidth) {\n return\n }\n\n this._saveInitialAttribute(element, styleProp)\n const calculatedValue = window.getComputedStyle(element)[styleProp]\n element.style[styleProp] = `${callback(Number.parseFloat(calculatedValue))}px`\n }\n\n this._applyManipulationCallback(selector, manipulationCallBack)\n }\n\n reset() {\n this._resetElementAttributes(this._element, 'overflow')\n this._resetElementAttributes(this._element, 'paddingRight')\n this._resetElementAttributes(SELECTOR_FIXED_CONTENT, 'paddingRight')\n this._resetElementAttributes(SELECTOR_STICKY_CONTENT, 'marginRight')\n }\n\n _saveInitialAttribute(element, styleProp) {\n const actualValue = element.style[styleProp]\n if (actualValue) {\n Manipulator.setDataAttribute(element, styleProp, actualValue)\n }\n }\n\n _resetElementAttributes(selector, styleProp) {\n const manipulationCallBack = element => {\n const value = Manipulator.getDataAttribute(element, styleProp)\n if (typeof value === 'undefined') {\n element.style.removeProperty(styleProp)\n } else {\n Manipulator.removeDataAttribute(element, styleProp)\n element.style[styleProp] = value\n }\n }\n\n this._applyManipulationCallback(selector, manipulationCallBack)\n }\n\n _applyManipulationCallback(selector, callBack) {\n if (isElement(selector)) {\n callBack(selector)\n } else {\n SelectorEngine.find(selector, this._element).forEach(callBack)\n }\n }\n\n isOverflowing() {\n return this.getWidth() > 0\n }\n}\n\nexport default ScrollBarHelper\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): util/backdrop.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler'\nimport { execute, executeAfterTransition, getElement, reflow, typeCheckConfig } from './index'\n\nconst Default = {\n className: 'modal-backdrop',\n isVisible: true, // if false, we use the backdrop helper without adding any element to the dom\n isAnimated: false,\n rootElement: 'body', // give the choice to place backdrop under different elements\n clickCallback: null\n}\n\nconst DefaultType = {\n className: 'string',\n isVisible: 'boolean',\n isAnimated: 'boolean',\n rootElement: '(element|string)',\n clickCallback: '(function|null)'\n}\nconst NAME = 'backdrop'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\n\nconst EVENT_MOUSEDOWN = `mousedown.bs.${NAME}`\n\nclass Backdrop {\n constructor(config) {\n this._config = this._getConfig(config)\n this._isAppended = false\n this._element = null\n }\n\n show(callback) {\n if (!this._config.isVisible) {\n execute(callback)\n return\n }\n\n this._append()\n\n if (this._config.isAnimated) {\n reflow(this._getElement())\n }\n\n this._getElement().classList.add(CLASS_NAME_SHOW)\n\n this._emulateAnimation(() => {\n execute(callback)\n })\n }\n\n hide(callback) {\n if (!this._config.isVisible) {\n execute(callback)\n return\n }\n\n this._getElement().classList.remove(CLASS_NAME_SHOW)\n\n this._emulateAnimation(() => {\n this.dispose()\n execute(callback)\n })\n }\n\n // Private\n\n _getElement() {\n if (!this._element) {\n const backdrop = document.createElement('div')\n backdrop.className = this._config.className\n if (this._config.isAnimated) {\n backdrop.classList.add(CLASS_NAME_FADE)\n }\n\n this._element = backdrop\n }\n\n return this._element\n }\n\n _getConfig(config) {\n config = {\n ...Default,\n ...(typeof config === 'object' ? config : {})\n }\n\n // use getElement() with the default \"body\" to get a fresh Element on each instantiation\n config.rootElement = getElement(config.rootElement)\n typeCheckConfig(NAME, config, DefaultType)\n return config\n }\n\n _append() {\n if (this._isAppended) {\n return\n }\n\n this._config.rootElement.append(this._getElement())\n\n EventHandler.on(this._getElement(), EVENT_MOUSEDOWN, () => {\n execute(this._config.clickCallback)\n })\n\n this._isAppended = true\n }\n\n dispose() {\n if (!this._isAppended) {\n return\n }\n\n EventHandler.off(this._element, EVENT_MOUSEDOWN)\n\n this._element.remove()\n this._isAppended = false\n }\n\n _emulateAnimation(callback) {\n executeAfterTransition(callback, this._getElement(), this._config.isAnimated)\n }\n}\n\nexport default Backdrop\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): util/focustrap.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler'\nimport SelectorEngine from '../dom/selector-engine'\nimport { typeCheckConfig } from './index'\n\nconst Default = {\n trapElement: null, // The element to trap focus inside of\n autofocus: true\n}\n\nconst DefaultType = {\n trapElement: 'element',\n autofocus: 'boolean'\n}\n\nconst NAME = 'focustrap'\nconst DATA_KEY = 'bs.focustrap'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst EVENT_FOCUSIN = `focusin${EVENT_KEY}`\nconst EVENT_KEYDOWN_TAB = `keydown.tab${EVENT_KEY}`\n\nconst TAB_KEY = 'Tab'\nconst TAB_NAV_FORWARD = 'forward'\nconst TAB_NAV_BACKWARD = 'backward'\n\nclass FocusTrap {\n constructor(config) {\n this._config = this._getConfig(config)\n this._isActive = false\n this._lastTabNavDirection = null\n }\n\n activate() {\n const { trapElement, autofocus } = this._config\n\n if (this._isActive) {\n return\n }\n\n if (autofocus) {\n trapElement.focus()\n }\n\n EventHandler.off(document, EVENT_KEY) // guard against infinite focus loop\n EventHandler.on(document, EVENT_FOCUSIN, event => this._handleFocusin(event))\n EventHandler.on(document, EVENT_KEYDOWN_TAB, event => this._handleKeydown(event))\n\n this._isActive = true\n }\n\n deactivate() {\n if (!this._isActive) {\n return\n }\n\n this._isActive = false\n EventHandler.off(document, EVENT_KEY)\n }\n\n // Private\n\n _handleFocusin(event) {\n const { target } = event\n const { trapElement } = this._config\n\n if (target === document || target === trapElement || trapElement.contains(target)) {\n return\n }\n\n const elements = SelectorEngine.focusableChildren(trapElement)\n\n if (elements.length === 0) {\n trapElement.focus()\n } else if (this._lastTabNavDirection === TAB_NAV_BACKWARD) {\n elements[elements.length - 1].focus()\n } else {\n elements[0].focus()\n }\n }\n\n _handleKeydown(event) {\n if (event.key !== TAB_KEY) {\n return\n }\n\n this._lastTabNavDirection = event.shiftKey ? TAB_NAV_BACKWARD : TAB_NAV_FORWARD\n }\n\n _getConfig(config) {\n config = {\n ...Default,\n ...(typeof config === 'object' ? config : {})\n }\n typeCheckConfig(NAME, config, DefaultType)\n return config\n }\n}\n\nexport default FocusTrap\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): modal.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n defineJQueryPlugin,\n getElementFromSelector,\n isRTL,\n isVisible,\n reflow,\n typeCheckConfig\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport ScrollBarHelper from './util/scrollbar'\nimport BaseComponent from './base-component'\nimport Backdrop from './util/backdrop'\nimport FocusTrap from './util/focustrap'\nimport { enableDismissTrigger } from './util/component-functions'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'modal'\nconst DATA_KEY = 'bs.modal'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst ESCAPE_KEY = 'Escape'\n\nconst Default = {\n backdrop: true,\n keyboard: true,\n focus: true\n}\n\nconst DefaultType = {\n backdrop: '(boolean|string)',\n keyboard: 'boolean',\n focus: 'boolean'\n}\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDE_PREVENTED = `hidePrevented${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_RESIZE = `resize${EVENT_KEY}`\nconst EVENT_CLICK_DISMISS = `click.dismiss${EVENT_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\nconst EVENT_MOUSEUP_DISMISS = `mouseup.dismiss${EVENT_KEY}`\nconst EVENT_MOUSEDOWN_DISMISS = `mousedown.dismiss${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_OPEN = 'modal-open'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_STATIC = 'modal-static'\n\nconst OPEN_SELECTOR = '.modal.show'\nconst SELECTOR_DIALOG = '.modal-dialog'\nconst SELECTOR_MODAL_BODY = '.modal-body'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"modal\"]'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Modal extends BaseComponent {\n constructor(element, config) {\n super(element)\n\n this._config = this._getConfig(config)\n this._dialog = SelectorEngine.findOne(SELECTOR_DIALOG, this._element)\n this._backdrop = this._initializeBackDrop()\n this._focustrap = this._initializeFocusTrap()\n this._isShown = false\n this._ignoreBackdropClick = false\n this._isTransitioning = false\n this._scrollBar = new ScrollBarHelper()\n }\n\n // Getters\n\n static get Default() {\n return Default\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n\n toggle(relatedTarget) {\n return this._isShown ? this.hide() : this.show(relatedTarget)\n }\n\n show(relatedTarget) {\n if (this._isShown || this._isTransitioning) {\n return\n }\n\n const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, {\n relatedTarget\n })\n\n if (showEvent.defaultPrevented) {\n return\n }\n\n this._isShown = true\n\n if (this._isAnimated()) {\n this._isTransitioning = true\n }\n\n this._scrollBar.hide()\n\n document.body.classList.add(CLASS_NAME_OPEN)\n\n this._adjustDialog()\n\n this._setEscapeEvent()\n this._setResizeEvent()\n\n EventHandler.on(this._dialog, EVENT_MOUSEDOWN_DISMISS, () => {\n EventHandler.one(this._element, EVENT_MOUSEUP_DISMISS, event => {\n if (event.target === this._element) {\n this._ignoreBackdropClick = true\n }\n })\n })\n\n this._showBackdrop(() => this._showElement(relatedTarget))\n }\n\n hide() {\n if (!this._isShown || this._isTransitioning) {\n return\n }\n\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n if (hideEvent.defaultPrevented) {\n return\n }\n\n this._isShown = false\n const isAnimated = this._isAnimated()\n\n if (isAnimated) {\n this._isTransitioning = true\n }\n\n this._setEscapeEvent()\n this._setResizeEvent()\n\n this._focustrap.deactivate()\n\n this._element.classList.remove(CLASS_NAME_SHOW)\n\n EventHandler.off(this._element, EVENT_CLICK_DISMISS)\n EventHandler.off(this._dialog, EVENT_MOUSEDOWN_DISMISS)\n\n this._queueCallback(() => this._hideModal(), this._element, isAnimated)\n }\n\n dispose() {\n [window, this._dialog]\n .forEach(htmlElement => EventHandler.off(htmlElement, EVENT_KEY))\n\n this._backdrop.dispose()\n this._focustrap.deactivate()\n super.dispose()\n }\n\n handleUpdate() {\n this._adjustDialog()\n }\n\n // Private\n\n _initializeBackDrop() {\n return new Backdrop({\n isVisible: Boolean(this._config.backdrop), // 'static' option will be translated to true, and booleans will keep their value\n isAnimated: this._isAnimated()\n })\n }\n\n _initializeFocusTrap() {\n return new FocusTrap({\n trapElement: this._element\n })\n }\n\n _getConfig(config) {\n config = {\n ...Default,\n ...Manipulator.getDataAttributes(this._element),\n ...(typeof config === 'object' ? config : {})\n }\n typeCheckConfig(NAME, config, DefaultType)\n return config\n }\n\n _showElement(relatedTarget) {\n const isAnimated = this._isAnimated()\n const modalBody = SelectorEngine.findOne(SELECTOR_MODAL_BODY, this._dialog)\n\n if (!this._element.parentNode || this._element.parentNode.nodeType !== Node.ELEMENT_NODE) {\n // Don't move modal's DOM position\n document.body.append(this._element)\n }\n\n this._element.style.display = 'block'\n this._element.removeAttribute('aria-hidden')\n this._element.setAttribute('aria-modal', true)\n this._element.setAttribute('role', 'dialog')\n this._element.scrollTop = 0\n\n if (modalBody) {\n modalBody.scrollTop = 0\n }\n\n if (isAnimated) {\n reflow(this._element)\n }\n\n this._element.classList.add(CLASS_NAME_SHOW)\n\n const transitionComplete = () => {\n if (this._config.focus) {\n this._focustrap.activate()\n }\n\n this._isTransitioning = false\n EventHandler.trigger(this._element, EVENT_SHOWN, {\n relatedTarget\n })\n }\n\n this._queueCallback(transitionComplete, this._dialog, isAnimated)\n }\n\n _setEscapeEvent() {\n if (this._isShown) {\n EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n if (this._config.keyboard && event.key === ESCAPE_KEY) {\n event.preventDefault()\n this.hide()\n } else if (!this._config.keyboard && event.key === ESCAPE_KEY) {\n this._triggerBackdropTransition()\n }\n })\n } else {\n EventHandler.off(this._element, EVENT_KEYDOWN_DISMISS)\n }\n }\n\n _setResizeEvent() {\n if (this._isShown) {\n EventHandler.on(window, EVENT_RESIZE, () => this._adjustDialog())\n } else {\n EventHandler.off(window, EVENT_RESIZE)\n }\n }\n\n _hideModal() {\n this._element.style.display = 'none'\n this._element.setAttribute('aria-hidden', true)\n this._element.removeAttribute('aria-modal')\n this._element.removeAttribute('role')\n this._isTransitioning = false\n this._backdrop.hide(() => {\n document.body.classList.remove(CLASS_NAME_OPEN)\n this._resetAdjustments()\n this._scrollBar.reset()\n EventHandler.trigger(this._element, EVENT_HIDDEN)\n })\n }\n\n _showBackdrop(callback) {\n EventHandler.on(this._element, EVENT_CLICK_DISMISS, event => {\n if (this._ignoreBackdropClick) {\n this._ignoreBackdropClick = false\n return\n }\n\n if (event.target !== event.currentTarget) {\n return\n }\n\n if (this._config.backdrop === true) {\n this.hide()\n } else if (this._config.backdrop === 'static') {\n this._triggerBackdropTransition()\n }\n })\n\n this._backdrop.show(callback)\n }\n\n _isAnimated() {\n return this._element.classList.contains(CLASS_NAME_FADE)\n }\n\n _triggerBackdropTransition() {\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n if (hideEvent.defaultPrevented) {\n return\n }\n\n const { classList, scrollHeight, style } = this._element\n const isModalOverflowing = scrollHeight > document.documentElement.clientHeight\n\n // return if the following background transition hasn't yet completed\n if ((!isModalOverflowing && style.overflowY === 'hidden') || classList.contains(CLASS_NAME_STATIC)) {\n return\n }\n\n if (!isModalOverflowing) {\n style.overflowY = 'hidden'\n }\n\n classList.add(CLASS_NAME_STATIC)\n this._queueCallback(() => {\n classList.remove(CLASS_NAME_STATIC)\n if (!isModalOverflowing) {\n this._queueCallback(() => {\n style.overflowY = ''\n }, this._dialog)\n }\n }, this._dialog)\n\n this._element.focus()\n }\n\n // ----------------------------------------------------------------------\n // the following methods are used to handle overflowing modals\n // ----------------------------------------------------------------------\n\n _adjustDialog() {\n const isModalOverflowing = this._element.scrollHeight > document.documentElement.clientHeight\n const scrollbarWidth = this._scrollBar.getWidth()\n const isBodyOverflowing = scrollbarWidth > 0\n\n if ((!isBodyOverflowing && isModalOverflowing && !isRTL()) || (isBodyOverflowing && !isModalOverflowing && isRTL())) {\n this._element.style.paddingLeft = `${scrollbarWidth}px`\n }\n\n if ((isBodyOverflowing && !isModalOverflowing && !isRTL()) || (!isBodyOverflowing && isModalOverflowing && isRTL())) {\n this._element.style.paddingRight = `${scrollbarWidth}px`\n }\n }\n\n _resetAdjustments() {\n this._element.style.paddingLeft = ''\n this._element.style.paddingRight = ''\n }\n\n // Static\n\n static jQueryInterface(config, relatedTarget) {\n return this.each(function () {\n const data = Modal.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config](relatedTarget)\n })\n }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n const target = getElementFromSelector(this)\n\n if (['A', 'AREA'].includes(this.tagName)) {\n event.preventDefault()\n }\n\n EventHandler.one(target, EVENT_SHOW, showEvent => {\n if (showEvent.defaultPrevented) {\n // only register focus restorer if modal will actually get shown\n return\n }\n\n EventHandler.one(target, EVENT_HIDDEN, () => {\n if (isVisible(this)) {\n this.focus()\n }\n })\n })\n\n // avoid conflict when clicking moddal toggler while another one is open\n const allReadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n if (allReadyOpen) {\n Modal.getInstance(allReadyOpen).hide()\n }\n\n const data = Modal.getOrCreateInstance(target)\n\n data.toggle(this)\n})\n\nenableDismissTrigger(Modal)\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Modal to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Modal)\n\nexport default Modal\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): offcanvas.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n defineJQueryPlugin,\n getElementFromSelector,\n isDisabled,\n isVisible,\n typeCheckConfig\n} from './util/index'\nimport ScrollBarHelper from './util/scrollbar'\nimport EventHandler from './dom/event-handler'\nimport BaseComponent from './base-component'\nimport SelectorEngine from './dom/selector-engine'\nimport Manipulator from './dom/manipulator'\nimport Backdrop from './util/backdrop'\nimport FocusTrap from './util/focustrap'\nimport { enableDismissTrigger } from './util/component-functions'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'offcanvas'\nconst DATA_KEY = 'bs.offcanvas'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst ESCAPE_KEY = 'Escape'\n\nconst Default = {\n backdrop: true,\n keyboard: true,\n scroll: false\n}\n\nconst DefaultType = {\n backdrop: 'boolean',\n keyboard: 'boolean',\n scroll: 'boolean'\n}\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_BACKDROP = 'offcanvas-backdrop'\nconst OPEN_SELECTOR = '.offcanvas.show'\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"offcanvas\"]'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Offcanvas extends BaseComponent {\n constructor(element, config) {\n super(element)\n\n this._config = this._getConfig(config)\n this._isShown = false\n this._backdrop = this._initializeBackDrop()\n this._focustrap = this._initializeFocusTrap()\n this._addEventListeners()\n }\n\n // Getters\n\n static get NAME() {\n return NAME\n }\n\n static get Default() {\n return Default\n }\n\n // Public\n\n toggle(relatedTarget) {\n return this._isShown ? this.hide() : this.show(relatedTarget)\n }\n\n show(relatedTarget) {\n if (this._isShown) {\n return\n }\n\n const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, { relatedTarget })\n\n if (showEvent.defaultPrevented) {\n return\n }\n\n this._isShown = true\n this._element.style.visibility = 'visible'\n\n this._backdrop.show()\n\n if (!this._config.scroll) {\n new ScrollBarHelper().hide()\n }\n\n this._element.removeAttribute('aria-hidden')\n this._element.setAttribute('aria-modal', true)\n this._element.setAttribute('role', 'dialog')\n this._element.classList.add(CLASS_NAME_SHOW)\n\n const completeCallBack = () => {\n if (!this._config.scroll) {\n this._focustrap.activate()\n }\n\n EventHandler.trigger(this._element, EVENT_SHOWN, { relatedTarget })\n }\n\n this._queueCallback(completeCallBack, this._element, true)\n }\n\n hide() {\n if (!this._isShown) {\n return\n }\n\n const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n if (hideEvent.defaultPrevented) {\n return\n }\n\n this._focustrap.deactivate()\n this._element.blur()\n this._isShown = false\n this._element.classList.remove(CLASS_NAME_SHOW)\n this._backdrop.hide()\n\n const completeCallback = () => {\n this._element.setAttribute('aria-hidden', true)\n this._element.removeAttribute('aria-modal')\n this._element.removeAttribute('role')\n this._element.style.visibility = 'hidden'\n\n if (!this._config.scroll) {\n new ScrollBarHelper().reset()\n }\n\n EventHandler.trigger(this._element, EVENT_HIDDEN)\n }\n\n this._queueCallback(completeCallback, this._element, true)\n }\n\n dispose() {\n this._backdrop.dispose()\n this._focustrap.deactivate()\n super.dispose()\n }\n\n // Private\n\n _getConfig(config) {\n config = {\n ...Default,\n ...Manipulator.getDataAttributes(this._element),\n ...(typeof config === 'object' ? config : {})\n }\n typeCheckConfig(NAME, config, DefaultType)\n return config\n }\n\n _initializeBackDrop() {\n return new Backdrop({\n className: CLASS_NAME_BACKDROP,\n isVisible: this._config.backdrop,\n isAnimated: true,\n rootElement: this._element.parentNode,\n clickCallback: () => this.hide()\n })\n }\n\n _initializeFocusTrap() {\n return new FocusTrap({\n trapElement: this._element\n })\n }\n\n _addEventListeners() {\n EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n if (this._config.keyboard && event.key === ESCAPE_KEY) {\n this.hide()\n }\n })\n }\n\n // Static\n\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Offcanvas.getOrCreateInstance(this, config)\n\n if (typeof config !== 'string') {\n return\n }\n\n if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config](this)\n })\n }\n}\n\n/**\n * ------------------------------------------------------------------------\n * Data Api implementation\n * ------------------------------------------------------------------------\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n const target = getElementFromSelector(this)\n\n if (['A', 'AREA'].includes(this.tagName)) {\n event.preventDefault()\n }\n\n if (isDisabled(this)) {\n return\n }\n\n EventHandler.one(target, EVENT_HIDDEN, () => {\n // focus on trigger when it is closed\n if (isVisible(this)) {\n this.focus()\n }\n })\n\n // avoid conflict when clicking a toggler of an offcanvas, while another is open\n const allReadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n if (allReadyOpen && allReadyOpen !== target) {\n Offcanvas.getInstance(allReadyOpen).hide()\n }\n\n const data = Offcanvas.getOrCreateInstance(target)\n data.toggle(this)\n})\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () =>\n SelectorEngine.find(OPEN_SELECTOR).forEach(el => Offcanvas.getOrCreateInstance(el).show())\n)\n\nenableDismissTrigger(Offcanvas)\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n */\n\ndefineJQueryPlugin(Offcanvas)\n\nexport default Offcanvas\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): util/sanitizer.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nconst uriAttributes = new Set([\n 'background',\n 'cite',\n 'href',\n 'itemtype',\n 'longdesc',\n 'poster',\n 'src',\n 'xlink:href'\n])\n\nconst ARIA_ATTRIBUTE_PATTERN = /^aria-[\\w-]*$/i\n\n/**\n * A pattern that recognizes a commonly useful subset of URLs that are safe.\n *\n * Shoutout to Angular https://github.com/angular/angular/blob/12.2.x/packages/core/src/sanitization/url_sanitizer.ts\n */\nconst SAFE_URL_PATTERN = /^(?:(?:https?|mailto|ftp|tel|file|sms):|[^#&/:?]*(?:[#/?]|$))/i\n\n/**\n * A pattern that matches safe data URLs. Only matches image, video and audio types.\n *\n * Shoutout to Angular https://github.com/angular/angular/blob/12.2.x/packages/core/src/sanitization/url_sanitizer.ts\n */\nconst DATA_URL_PATTERN = /^data:(?:image\\/(?:bmp|gif|jpeg|jpg|png|tiff|webp)|video\\/(?:mpeg|mp4|ogg|webm)|audio\\/(?:mp3|oga|ogg|opus));base64,[\\d+/a-z]+=*$/i\n\nconst allowedAttribute = (attribute, allowedAttributeList) => {\n const attributeName = attribute.nodeName.toLowerCase()\n\n if (allowedAttributeList.includes(attributeName)) {\n if (uriAttributes.has(attributeName)) {\n return Boolean(SAFE_URL_PATTERN.test(attribute.nodeValue) || DATA_URL_PATTERN.test(attribute.nodeValue))\n }\n\n return true\n }\n\n const regExp = allowedAttributeList.filter(attributeRegex => attributeRegex instanceof RegExp)\n\n // Check if a regular expression validates the attribute.\n for (let i = 0, len = regExp.length; i < len; i++) {\n if (regExp[i].test(attributeName)) {\n return true\n }\n }\n\n return false\n}\n\nexport const DefaultAllowlist = {\n // Global attributes allowed on any supplied element below.\n '*': ['class', 'dir', 'id', 'lang', 'role', ARIA_ATTRIBUTE_PATTERN],\n a: ['target', 'href', 'title', 'rel'],\n area: [],\n b: [],\n br: [],\n col: [],\n code: [],\n div: [],\n em: [],\n hr: [],\n h1: [],\n h2: [],\n h3: [],\n h4: [],\n h5: [],\n h6: [],\n i: [],\n img: ['src', 'srcset', 'alt', 'title', 'width', 'height'],\n li: [],\n ol: [],\n p: [],\n pre: [],\n s: [],\n small: [],\n span: [],\n sub: [],\n sup: [],\n strong: [],\n u: [],\n ul: []\n}\n\nexport function sanitizeHtml(unsafeHtml, allowList, sanitizeFn) {\n if (!unsafeHtml.length) {\n return unsafeHtml\n }\n\n if (sanitizeFn && typeof sanitizeFn === 'function') {\n return sanitizeFn(unsafeHtml)\n }\n\n const domParser = new window.DOMParser()\n const createdDocument = domParser.parseFromString(unsafeHtml, 'text/html')\n const elements = [].concat(...createdDocument.body.querySelectorAll('*'))\n\n for (let i = 0, len = elements.length; i < len; i++) {\n const element = elements[i]\n const elementName = element.nodeName.toLowerCase()\n\n if (!Object.keys(allowList).includes(elementName)) {\n element.remove()\n\n continue\n }\n\n const attributeList = [].concat(...element.attributes)\n const allowedAttributes = [].concat(allowList['*'] || [], allowList[elementName] || [])\n\n attributeList.forEach(attribute => {\n if (!allowedAttribute(attribute, allowedAttributes)) {\n element.removeAttribute(attribute.nodeName)\n }\n })\n }\n\n return createdDocument.body.innerHTML\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): tooltip.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\n\nimport {\n defineJQueryPlugin,\n findShadowRoot,\n getElement,\n getUID,\n isElement,\n isRTL,\n noop,\n typeCheckConfig\n} from './util/index'\nimport { DefaultAllowlist, sanitizeHtml } from './util/sanitizer'\nimport Data from './dom/data'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'tooltip'\nconst DATA_KEY = 'bs.tooltip'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst CLASS_PREFIX = 'bs-tooltip'\nconst DISALLOWED_ATTRIBUTES = new Set(['sanitize', 'allowList', 'sanitizeFn'])\n\nconst DefaultType = {\n animation: 'boolean',\n template: 'string',\n title: '(string|element|function)',\n trigger: 'string',\n delay: '(number|object)',\n html: 'boolean',\n selector: '(string|boolean)',\n placement: '(string|function)',\n offset: '(array|string|function)',\n container: '(string|element|boolean)',\n fallbackPlacements: 'array',\n boundary: '(string|element)',\n customClass: '(string|function)',\n sanitize: 'boolean',\n sanitizeFn: '(null|function)',\n allowList: 'object',\n popperConfig: '(null|object|function)'\n}\n\nconst AttachmentMap = {\n AUTO: 'auto',\n TOP: 'top',\n RIGHT: isRTL() ? 'left' : 'right',\n BOTTOM: 'bottom',\n LEFT: isRTL() ? 'right' : 'left'\n}\n\nconst Default = {\n animation: true,\n template: '
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',\n trigger: 'hover focus',\n title: '',\n delay: 0,\n html: false,\n selector: false,\n placement: 'top',\n offset: [0, 0],\n container: false,\n fallbackPlacements: ['top', 'right', 'bottom', 'left'],\n boundary: 'clippingParents',\n customClass: '',\n sanitize: true,\n sanitizeFn: null,\n allowList: DefaultAllowlist,\n popperConfig: null\n}\n\nconst Event = {\n HIDE: `hide${EVENT_KEY}`,\n HIDDEN: `hidden${EVENT_KEY}`,\n SHOW: `show${EVENT_KEY}`,\n SHOWN: `shown${EVENT_KEY}`,\n INSERTED: `inserted${EVENT_KEY}`,\n CLICK: `click${EVENT_KEY}`,\n FOCUSIN: `focusin${EVENT_KEY}`,\n FOCUSOUT: `focusout${EVENT_KEY}`,\n MOUSEENTER: `mouseenter${EVENT_KEY}`,\n MOUSELEAVE: `mouseleave${EVENT_KEY}`\n}\n\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_MODAL = 'modal'\nconst CLASS_NAME_SHOW = 'show'\n\nconst HOVER_STATE_SHOW = 'show'\nconst HOVER_STATE_OUT = 'out'\n\nconst SELECTOR_TOOLTIP_INNER = '.tooltip-inner'\nconst SELECTOR_MODAL = `.${CLASS_NAME_MODAL}`\n\nconst EVENT_MODAL_HIDE = 'hide.bs.modal'\n\nconst TRIGGER_HOVER = 'hover'\nconst TRIGGER_FOCUS = 'focus'\nconst TRIGGER_CLICK = 'click'\nconst TRIGGER_MANUAL = 'manual'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Tooltip extends BaseComponent {\n constructor(element, config) {\n if (typeof Popper === 'undefined') {\n throw new TypeError('Bootstrap\\'s tooltips require Popper (https://popper.js.org)')\n }\n\n super(element)\n\n // private\n this._isEnabled = true\n this._timeout = 0\n this._hoverState = ''\n this._activeTrigger = {}\n this._popper = null\n\n // Protected\n this._config = this._getConfig(config)\n this.tip = null\n\n this._setListeners()\n }\n\n // Getters\n\n static get Default() {\n return Default\n }\n\n static get NAME() {\n return NAME\n }\n\n static get Event() {\n return Event\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n // Public\n\n enable() {\n this._isEnabled = true\n }\n\n disable() {\n this._isEnabled = false\n }\n\n toggleEnabled() {\n this._isEnabled = !this._isEnabled\n }\n\n toggle(event) {\n if (!this._isEnabled) {\n return\n }\n\n if (event) {\n const context = this._initializeOnDelegatedTarget(event)\n\n context._activeTrigger.click = !context._activeTrigger.click\n\n if (context._isWithActiveTrigger()) {\n context._enter(null, context)\n } else {\n context._leave(null, context)\n }\n } else {\n if (this.getTipElement().classList.contains(CLASS_NAME_SHOW)) {\n this._leave(null, this)\n return\n }\n\n this._enter(null, this)\n }\n }\n\n dispose() {\n clearTimeout(this._timeout)\n\n EventHandler.off(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n\n if (this.tip) {\n this.tip.remove()\n }\n\n this._disposePopper()\n super.dispose()\n }\n\n show() {\n if (this._element.style.display === 'none') {\n throw new Error('Please use show on visible elements')\n }\n\n if (!(this.isWithContent() && this._isEnabled)) {\n return\n }\n\n const showEvent = EventHandler.trigger(this._element, this.constructor.Event.SHOW)\n const shadowRoot = findShadowRoot(this._element)\n const isInTheDom = shadowRoot === null ?\n this._element.ownerDocument.documentElement.contains(this._element) :\n shadowRoot.contains(this._element)\n\n if (showEvent.defaultPrevented || !isInTheDom) {\n return\n }\n\n // A trick to recreate a tooltip in case a new title is given by using the NOT documented `data-bs-original-title`\n // This will be removed later in favor of a `setContent` method\n if (this.constructor.NAME === 'tooltip' && this.tip && this.getTitle() !== this.tip.querySelector(SELECTOR_TOOLTIP_INNER).innerHTML) {\n this._disposePopper()\n this.tip.remove()\n this.tip = null\n }\n\n const tip = this.getTipElement()\n const tipId = getUID(this.constructor.NAME)\n\n tip.setAttribute('id', tipId)\n this._element.setAttribute('aria-describedby', tipId)\n\n if (this._config.animation) {\n tip.classList.add(CLASS_NAME_FADE)\n }\n\n const placement = typeof this._config.placement === 'function' ?\n this._config.placement.call(this, tip, this._element) :\n this._config.placement\n\n const attachment = this._getAttachment(placement)\n this._addAttachmentClass(attachment)\n\n const { container } = this._config\n Data.set(tip, this.constructor.DATA_KEY, this)\n\n if (!this._element.ownerDocument.documentElement.contains(this.tip)) {\n container.append(tip)\n EventHandler.trigger(this._element, this.constructor.Event.INSERTED)\n }\n\n if (this._popper) {\n this._popper.update()\n } else {\n this._popper = Popper.createPopper(this._element, tip, this._getPopperConfig(attachment))\n }\n\n tip.classList.add(CLASS_NAME_SHOW)\n\n const customClass = this._resolvePossibleFunction(this._config.customClass)\n if (customClass) {\n tip.classList.add(...customClass.split(' '))\n }\n\n // If this is a touch-enabled device we add extra\n // empty mouseover listeners to the body's immediate children;\n // only needed because of broken event delegation on iOS\n // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n if ('ontouchstart' in document.documentElement) {\n [].concat(...document.body.children).forEach(element => {\n EventHandler.on(element, 'mouseover', noop)\n })\n }\n\n const complete = () => {\n const prevHoverState = this._hoverState\n\n this._hoverState = null\n EventHandler.trigger(this._element, this.constructor.Event.SHOWN)\n\n if (prevHoverState === HOVER_STATE_OUT) {\n this._leave(null, this)\n }\n }\n\n const isAnimated = this.tip.classList.contains(CLASS_NAME_FADE)\n this._queueCallback(complete, this.tip, isAnimated)\n }\n\n hide() {\n if (!this._popper) {\n return\n }\n\n const tip = this.getTipElement()\n const complete = () => {\n if (this._isWithActiveTrigger()) {\n return\n }\n\n if (this._hoverState !== HOVER_STATE_SHOW) {\n tip.remove()\n }\n\n this._cleanTipClass()\n this._element.removeAttribute('aria-describedby')\n EventHandler.trigger(this._element, this.constructor.Event.HIDDEN)\n\n this._disposePopper()\n }\n\n const hideEvent = EventHandler.trigger(this._element, this.constructor.Event.HIDE)\n if (hideEvent.defaultPrevented) {\n return\n }\n\n tip.classList.remove(CLASS_NAME_SHOW)\n\n // If this is a touch-enabled device we remove the extra\n // empty mouseover listeners we added for iOS support\n if ('ontouchstart' in document.documentElement) {\n [].concat(...document.body.children)\n .forEach(element => EventHandler.off(element, 'mouseover', noop))\n }\n\n this._activeTrigger[TRIGGER_CLICK] = false\n this._activeTrigger[TRIGGER_FOCUS] = false\n this._activeTrigger[TRIGGER_HOVER] = false\n\n const isAnimated = this.tip.classList.contains(CLASS_NAME_FADE)\n this._queueCallback(complete, this.tip, isAnimated)\n this._hoverState = ''\n }\n\n update() {\n if (this._popper !== null) {\n this._popper.update()\n }\n }\n\n // Protected\n\n isWithContent() {\n return Boolean(this.getTitle())\n }\n\n getTipElement() {\n if (this.tip) {\n return this.tip\n }\n\n const element = document.createElement('div')\n element.innerHTML = this._config.template\n\n const tip = element.children[0]\n this.setContent(tip)\n tip.classList.remove(CLASS_NAME_FADE, CLASS_NAME_SHOW)\n\n this.tip = tip\n return this.tip\n }\n\n setContent(tip) {\n this._sanitizeAndSetContent(tip, this.getTitle(), SELECTOR_TOOLTIP_INNER)\n }\n\n _sanitizeAndSetContent(template, content, selector) {\n const templateElement = SelectorEngine.findOne(selector, template)\n\n if (!content && templateElement) {\n templateElement.remove()\n return\n }\n\n // we use append for html objects to maintain js events\n this.setElementContent(templateElement, content)\n }\n\n setElementContent(element, content) {\n if (element === null) {\n return\n }\n\n if (isElement(content)) {\n content = getElement(content)\n\n // content is a DOM node or a jQuery\n if (this._config.html) {\n if (content.parentNode !== element) {\n element.innerHTML = ''\n element.append(content)\n }\n } else {\n element.textContent = content.textContent\n }\n\n return\n }\n\n if (this._config.html) {\n if (this._config.sanitize) {\n content = sanitizeHtml(content, this._config.allowList, this._config.sanitizeFn)\n }\n\n element.innerHTML = content\n } else {\n element.textContent = content\n }\n }\n\n getTitle() {\n const title = this._element.getAttribute('data-bs-original-title') || this._config.title\n\n return this._resolvePossibleFunction(title)\n }\n\n updateAttachment(attachment) {\n if (attachment === 'right') {\n return 'end'\n }\n\n if (attachment === 'left') {\n return 'start'\n }\n\n return attachment\n }\n\n // Private\n\n _initializeOnDelegatedTarget(event, context) {\n return context || this.constructor.getOrCreateInstance(event.delegateTarget, this._getDelegateConfig())\n }\n\n _getOffset() {\n const { offset } = this._config\n\n if (typeof offset === 'string') {\n return offset.split(',').map(val => Number.parseInt(val, 10))\n }\n\n if (typeof offset === 'function') {\n return popperData => offset(popperData, this._element)\n }\n\n return offset\n }\n\n _resolvePossibleFunction(content) {\n return typeof content === 'function' ? content.call(this._element) : content\n }\n\n _getPopperConfig(attachment) {\n const defaultBsPopperConfig = {\n placement: attachment,\n modifiers: [\n {\n name: 'flip',\n options: {\n fallbackPlacements: this._config.fallbackPlacements\n }\n },\n {\n name: 'offset',\n options: {\n offset: this._getOffset()\n }\n },\n {\n name: 'preventOverflow',\n options: {\n boundary: this._config.boundary\n }\n },\n {\n name: 'arrow',\n options: {\n element: `.${this.constructor.NAME}-arrow`\n }\n },\n {\n name: 'onChange',\n enabled: true,\n phase: 'afterWrite',\n fn: data => this._handlePopperPlacementChange(data)\n }\n ],\n onFirstUpdate: data => {\n if (data.options.placement !== data.placement) {\n this._handlePopperPlacementChange(data)\n }\n }\n }\n\n return {\n ...defaultBsPopperConfig,\n ...(typeof this._config.popperConfig === 'function' ? this._config.popperConfig(defaultBsPopperConfig) : this._config.popperConfig)\n }\n }\n\n _addAttachmentClass(attachment) {\n this.getTipElement().classList.add(`${this._getBasicClassPrefix()}-${this.updateAttachment(attachment)}`)\n }\n\n _getAttachment(placement) {\n return AttachmentMap[placement.toUpperCase()]\n }\n\n _setListeners() {\n const triggers = this._config.trigger.split(' ')\n\n triggers.forEach(trigger => {\n if (trigger === 'click') {\n EventHandler.on(this._element, this.constructor.Event.CLICK, this._config.selector, event => this.toggle(event))\n } else if (trigger !== TRIGGER_MANUAL) {\n const eventIn = trigger === TRIGGER_HOVER ?\n this.constructor.Event.MOUSEENTER :\n this.constructor.Event.FOCUSIN\n const eventOut = trigger === TRIGGER_HOVER ?\n this.constructor.Event.MOUSELEAVE :\n this.constructor.Event.FOCUSOUT\n\n EventHandler.on(this._element, eventIn, this._config.selector, event => this._enter(event))\n EventHandler.on(this._element, eventOut, this._config.selector, event => this._leave(event))\n }\n })\n\n this._hideModalHandler = () => {\n if (this._element) {\n this.hide()\n }\n }\n\n EventHandler.on(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n\n if (this._config.selector) {\n this._config = {\n ...this._config,\n trigger: 'manual',\n selector: ''\n }\n } else {\n this._fixTitle()\n }\n }\n\n _fixTitle() {\n const title = this._element.getAttribute('title')\n const originalTitleType = typeof this._element.getAttribute('data-bs-original-title')\n\n if (title || originalTitleType !== 'string') {\n this._element.setAttribute('data-bs-original-title', title || '')\n if (title && !this._element.getAttribute('aria-label') && !this._element.textContent) {\n this._element.setAttribute('aria-label', title)\n }\n\n this._element.setAttribute('title', '')\n }\n }\n\n _enter(event, context) {\n context = this._initializeOnDelegatedTarget(event, context)\n\n if (event) {\n context._activeTrigger[\n event.type === 'focusin' ? TRIGGER_FOCUS : TRIGGER_HOVER\n ] = true\n }\n\n if (context.getTipElement().classList.contains(CLASS_NAME_SHOW) || context._hoverState === HOVER_STATE_SHOW) {\n context._hoverState = HOVER_STATE_SHOW\n return\n }\n\n clearTimeout(context._timeout)\n\n context._hoverState = HOVER_STATE_SHOW\n\n if (!context._config.delay || !context._config.delay.show) {\n context.show()\n return\n }\n\n context._timeout = setTimeout(() => {\n if (context._hoverState === HOVER_STATE_SHOW) {\n context.show()\n }\n }, context._config.delay.show)\n }\n\n _leave(event, context) {\n context = this._initializeOnDelegatedTarget(event, context)\n\n if (event) {\n context._activeTrigger[\n event.type === 'focusout' ? TRIGGER_FOCUS : TRIGGER_HOVER\n ] = context._element.contains(event.relatedTarget)\n }\n\n if (context._isWithActiveTrigger()) {\n return\n }\n\n clearTimeout(context._timeout)\n\n context._hoverState = HOVER_STATE_OUT\n\n if (!context._config.delay || !context._config.delay.hide) {\n context.hide()\n return\n }\n\n context._timeout = setTimeout(() => {\n if (context._hoverState === HOVER_STATE_OUT) {\n context.hide()\n }\n }, context._config.delay.hide)\n }\n\n _isWithActiveTrigger() {\n for (const trigger in this._activeTrigger) {\n if (this._activeTrigger[trigger]) {\n return true\n }\n }\n\n return false\n }\n\n _getConfig(config) {\n const dataAttributes = Manipulator.getDataAttributes(this._element)\n\n Object.keys(dataAttributes).forEach(dataAttr => {\n if (DISALLOWED_ATTRIBUTES.has(dataAttr)) {\n delete dataAttributes[dataAttr]\n }\n })\n\n config = {\n ...this.constructor.Default,\n ...dataAttributes,\n ...(typeof config === 'object' && config ? config : {})\n }\n\n config.container = config.container === false ? document.body : getElement(config.container)\n\n if (typeof config.delay === 'number') {\n config.delay = {\n show: config.delay,\n hide: config.delay\n }\n }\n\n if (typeof config.title === 'number') {\n config.title = config.title.toString()\n }\n\n if (typeof config.content === 'number') {\n config.content = config.content.toString()\n }\n\n typeCheckConfig(NAME, config, this.constructor.DefaultType)\n\n if (config.sanitize) {\n config.template = sanitizeHtml(config.template, config.allowList, config.sanitizeFn)\n }\n\n return config\n }\n\n _getDelegateConfig() {\n const config = {}\n\n for (const key in this._config) {\n if (this.constructor.Default[key] !== this._config[key]) {\n config[key] = this._config[key]\n }\n }\n\n // In the future can be replaced with:\n // const keysWithDifferentValues = Object.entries(this._config).filter(entry => this.constructor.Default[entry[0]] !== this._config[entry[0]])\n // `Object.fromEntries(keysWithDifferentValues)`\n return config\n }\n\n _cleanTipClass() {\n const tip = this.getTipElement()\n const basicClassPrefixRegex = new RegExp(`(^|\\\\s)${this._getBasicClassPrefix()}\\\\S+`, 'g')\n const tabClass = tip.getAttribute('class').match(basicClassPrefixRegex)\n if (tabClass !== null && tabClass.length > 0) {\n tabClass.map(token => token.trim())\n .forEach(tClass => tip.classList.remove(tClass))\n }\n }\n\n _getBasicClassPrefix() {\n return CLASS_PREFIX\n }\n\n _handlePopperPlacementChange(popperData) {\n const { state } = popperData\n\n if (!state) {\n return\n }\n\n this.tip = state.elements.popper\n this._cleanTipClass()\n this._addAttachmentClass(this._getAttachment(state.placement))\n }\n\n _disposePopper() {\n if (this._popper) {\n this._popper.destroy()\n this._popper = null\n }\n }\n\n // Static\n\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Tooltip.getOrCreateInstance(this, config)\n\n if (typeof config === 'string') {\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n }\n })\n }\n}\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Tooltip to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Tooltip)\n\nexport default Tooltip\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): popover.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { defineJQueryPlugin } from './util/index'\nimport Tooltip from './tooltip'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'popover'\nconst DATA_KEY = 'bs.popover'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst CLASS_PREFIX = 'bs-popover'\n\nconst Default = {\n ...Tooltip.Default,\n placement: 'right',\n offset: [0, 8],\n trigger: 'click',\n content: '',\n template: '
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' +\n '
' +\n '
'\n}\n\nconst DefaultType = {\n ...Tooltip.DefaultType,\n content: '(string|element|function)'\n}\n\nconst Event = {\n HIDE: `hide${EVENT_KEY}`,\n HIDDEN: `hidden${EVENT_KEY}`,\n SHOW: `show${EVENT_KEY}`,\n SHOWN: `shown${EVENT_KEY}`,\n INSERTED: `inserted${EVENT_KEY}`,\n CLICK: `click${EVENT_KEY}`,\n FOCUSIN: `focusin${EVENT_KEY}`,\n FOCUSOUT: `focusout${EVENT_KEY}`,\n MOUSEENTER: `mouseenter${EVENT_KEY}`,\n MOUSELEAVE: `mouseleave${EVENT_KEY}`\n}\n\nconst SELECTOR_TITLE = '.popover-header'\nconst SELECTOR_CONTENT = '.popover-body'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass Popover extends Tooltip {\n // Getters\n\n static get Default() {\n return Default\n }\n\n static get NAME() {\n return NAME\n }\n\n static get Event() {\n return Event\n }\n\n static get DefaultType() {\n return DefaultType\n }\n\n // Overrides\n\n isWithContent() {\n return this.getTitle() || this._getContent()\n }\n\n setContent(tip) {\n this._sanitizeAndSetContent(tip, this.getTitle(), SELECTOR_TITLE)\n this._sanitizeAndSetContent(tip, this._getContent(), SELECTOR_CONTENT)\n }\n\n // Private\n\n _getContent() {\n return this._resolvePossibleFunction(this._config.content)\n }\n\n _getBasicClassPrefix() {\n return CLASS_PREFIX\n }\n\n // Static\n\n static jQueryInterface(config) {\n return this.each(function () {\n const data = Popover.getOrCreateInstance(this, config)\n\n if (typeof config === 'string') {\n if (typeof data[config] === 'undefined') {\n throw new TypeError(`No method named \"${config}\"`)\n }\n\n data[config]()\n }\n })\n }\n}\n\n/**\n * ------------------------------------------------------------------------\n * jQuery\n * ------------------------------------------------------------------------\n * add .Popover to jQuery only if jQuery is present\n */\n\ndefineJQueryPlugin(Popover)\n\nexport default Popover\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap (v5.1.3): scrollspy.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport {\n defineJQueryPlugin,\n getElement,\n getSelectorFromElement,\n typeCheckConfig\n} from './util/index'\nimport EventHandler from './dom/event-handler'\nimport Manipulator from './dom/manipulator'\nimport SelectorEngine from './dom/selector-engine'\nimport BaseComponent from './base-component'\n\n/**\n * ------------------------------------------------------------------------\n * Constants\n * ------------------------------------------------------------------------\n */\n\nconst NAME = 'scrollspy'\nconst DATA_KEY = 'bs.scrollspy'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst Default = {\n offset: 10,\n method: 'auto',\n target: ''\n}\n\nconst DefaultType = {\n offset: 'number',\n method: 'string',\n target: '(string|element)'\n}\n\nconst EVENT_ACTIVATE = `activate${EVENT_KEY}`\nconst EVENT_SCROLL = `scroll${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_DROPDOWN_ITEM = 'dropdown-item'\nconst CLASS_NAME_ACTIVE = 'active'\n\nconst SELECTOR_DATA_SPY = '[data-bs-spy=\"scroll\"]'\nconst SELECTOR_NAV_LIST_GROUP = '.nav, .list-group'\nconst SELECTOR_NAV_LINKS = '.nav-link'\nconst SELECTOR_NAV_ITEMS = '.nav-item'\nconst SELECTOR_LIST_ITEMS = '.list-group-item'\nconst SELECTOR_LINK_ITEMS = `${SELECTOR_NAV_LINKS}, ${SELECTOR_LIST_ITEMS}, .${CLASS_NAME_DROPDOWN_ITEM}`\nconst SELECTOR_DROPDOWN = '.dropdown'\nconst SELECTOR_DROPDOWN_TOGGLE = '.dropdown-toggle'\n\nconst METHOD_OFFSET = 'offset'\nconst METHOD_POSITION = 'position'\n\n/**\n * ------------------------------------------------------------------------\n * Class Definition\n * ------------------------------------------------------------------------\n */\n\nclass ScrollSpy extends BaseComponent {\n constructor(element, config) {\n super(element)\n this._scrollElement = this._element.tagName === 'BODY' ? window : this._element\n this._config = this._getConfig(config)\n this._offsets = []\n this._targets = []\n this._activeTarget = null\n this._scrollHeight = 0\n\n EventHandler.on(this._scrollElement, EVENT_SCROLL, () => this._process())\n\n this.refresh()\n this._process()\n }\n\n // Getters\n\n static get Default() {\n return Default\n }\n\n static get NAME() {\n return NAME\n }\n\n // Public\n\n refresh() {\n const autoMethod = this._scrollElement === this._scrollElement.window ?\n METHOD_OFFSET :\n METHOD_POSITION\n\n const offsetMethod = this._config.method === 'auto' ?\n autoMethod :\n this._config.method\n\n const offsetBase = offsetMethod === METHOD_POSITION ?\n this._getScrollTop() :\n 0\n\n this._offsets = []\n this._targets = []\n this._scrollHeight = this._getScrollHeight()\n\n const targets = SelectorEngine.find(SELECTOR_LINK_ITEMS, this._config.target)\n\n targets.map(element => {\n const targetSelector = getSelectorFromElement(element)\n const target = targetSelector ? SelectorEngine.findOne(targetSelector) : null\n\n if (target) {\n const targetBCR = target.getBoundingClientRect()\n if (targetBCR.width || targetBCR.height) {\n return [\n Manipulator[offsetMethod](target).top + offsetBase,\n targetSelector\n ]\n }\n }\n\n return null\n })\n .filter(item => item)\n .sort((a, b) => a[0] - b[0])\n .forEach(item => {\n this._offsets.push(item[0])\n this._targets.push(item[1])\n })\n }\n\n dispose() {\n EventHandler.off(this._scrollElement, EVENT_KEY)\n super.dispose()\n }\n\n // Private\n\n _getConfig(config) {\n config = {\n ...Default,\n ...Manipulator.getDataAttributes(this._element),\n ...(typeof config === 'object' && config ? config : {})\n }\n\n config.target = getElement(config.target) || document.documentElement\n\n typeCheckConfig(NAME, config, DefaultType)\n\n return config\n }\n\n _getScrollTop() {\n return this._scrollElement === window ?\n this._scrollElement.pageYOffset :\n this._scrollElement.scrollTop\n }\n\n _getScrollHeight() {\n return this._scrollElement.scrollHeight || Math.max(\n document.body.scrollHeight,\n document.documentElement.scrollHeight\n )\n }\n\n _getOffsetHeight() {\n return this._scrollElement === window ?\n window.innerHeight :\n this._scrollElement.getBoundingClientRect().height\n }\n\n _process() {\n const scrollTop = this._getScrollTop() + this._config.offset\n const scrollHeight = this._getScrollHeight()\n const maxScroll = this._config.offset + scrollHeight - this._getOffsetHeight()\n\n if (this._scrollHeight !== scrollHeight) {\n this.refresh()\n }\n\n if (scrollTop >= maxScroll) {\n const target = this._targets[this._targets.length - 1]\n\n if (this._activeTarget !== target) {\n this._activate(target)\n }\n\n return\n }\n\n if (this._activeTarget && scrollTop < this._offsets[0] && this._offsets[0] > 0) {\n this._activeTarget = null\n this._clear()\n return\n }\n\n for (let i = this._offsets.length; i--;) {\n const isActiveTarget = this._activeTarget !== this._targets[i] &&\n scrollTop >= this._offsets[i] &&\n (typeof this._offsets[i + 1] === 'undefined' || scrollTop < this._offsets[i + 1])\n\n if (isActiveTarget) {\n this._activate(this._targets[i])\n }\n }\n }\n\n _activate(target) {\n this._activeTarget = target\n\n this._clear()\n\n const queries = SELECTOR_LINK_ITEMS.split(',')\n .map(selector => `${selector}[data-bs-target=\"${target}\"],${selector}[href=\"${target}\"]`)\n\n const link = SelectorEngine.findOne(queries.join(','), this._config.target)\n\n link.classList.add(CLASS_NAME_ACTIVE)\n if (link.classList.contains(CLASS_NAME_DROPDOWN_ITEM)) {\n SelectorEngine.findOne(SELECTOR_DROPDOWN_TOGGLE, link.closest(SELECTOR_DROPDOWN))\n .classList.add(CLASS_NAME_ACTIVE)\n } else {\n SelectorEngine.parents(link, SELECTOR_NAV_LIST_GROUP)\n .forEach(listGroup => {\n // Set triggered links parents as active\n // With both
    and