diff --git a/DESCRIPTION b/DESCRIPTION
index 93a2c9f72..1bfeea3a8 100644
--- a/DESCRIPTION
+++ b/DESCRIPTION
@@ -1,5 +1,5 @@
 Package: AMR
-Version: 2.1.1.9031
+Version: 2.1.1.9032
 Date: 2024-05-20
 Title: Antimicrobial Resistance Data Analysis
 Description: Functions to simplify and standardise antimicrobial resistance (AMR)
diff --git a/NEWS.md b/NEWS.md
index 52848c783..12d3dbfbd 100644
--- a/NEWS.md
+++ b/NEWS.md
@@ -1,4 +1,4 @@
-# AMR 2.1.1.9031
+# AMR 2.1.1.9032
 
 *(this beta version will eventually become v3.0. We're happy to reach a new major milestone soon, which will be all about the new One Health support!)*
 
@@ -21,6 +21,7 @@ This package now supports not only tools for AMR data analysis in clinical setti
 * Function `mo_group_members()` to retrieve the member microorganisms. For example, `mo_group_members("Strep group C")` returns a vector of all microorganisms that are in that group.
 
 ## Changed
+* For SIR interpretation, it is now possible to use column names for argument `ab` and `mo`: `as.sir(..., ab = "column1", mo = "column2")`. This greatly improves the flexibility for users.
 * For MICs:
   * Added as valid levels: 4096, 6 powers of 0.0625, and 5 powers of 192 (192, 384, 576, 768, 960)
   * Added new argument `keep_operators` to `as.mic()`. This can be `"all"` (default), `"none"`, or `"edges"`. This argument is also available in the new `limit_mic_range()` and `scale_*_mic()` functions.
diff --git a/R/aa_helper_functions.R b/R/aa_helper_functions.R
index e336aa4c4..509110a88 100644
--- a/R/aa_helper_functions.R
+++ b/R/aa_helper_functions.R
@@ -1049,10 +1049,15 @@ get_current_column <- function() {
     if (tryCatch(!is.null(env$i), error = function(e) FALSE)) {
       if (!is.null(env$tibble_vars)) {
         # for mutate_if()
+        # TODO remove later, was part of older dplyr versions (at least not in dplyr 1.1.4)
         env$tibble_vars[env$i]
       } else {
         # for mutate(across())
-        df <- tryCatch(get_current_data(NA, 0), error = function(e) NULL)
+        if (!is.null(env$data) && is.data.frame(env$data)) {
+          df <- env$data
+        } else {
+          df <- tryCatch(get_current_data(NA, 0), error = function(e) NULL)
+        }
         if (is.data.frame(df)) {
           colnames(df)[env$i]
         } else {
diff --git a/R/ab.R b/R/ab.R
index c53a6efcd..9bddfb895 100755
--- a/R/ab.R
+++ b/R/ab.R
@@ -322,13 +322,12 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
     }
 
     # INITIAL SEARCH - More uncertain results ----
-
     if (loop_time <= 2 && fast_mode == FALSE) {
       # only run on first and second try
 
       # try by removing all spaces
       if (x[i] %like% " ") {
-        found <- suppressWarnings(as.ab(gsub(" +", "", x[i], perl = TRUE), loop_time = loop_time + 1))
+        found <- suppressWarnings(as.ab(gsub(" +", "", x[i], perl = TRUE), loop_time = loop_time + 2))
         if (length(found) > 0 && !is.na(found)) {
           x_new[i] <- note_if_more_than_one_found(found, i, from_text)
           next
@@ -337,7 +336,7 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
 
       # try by removing all spaces and numbers
       if (x[i] %like% " " || x[i] %like% "[0-9]") {
-        found <- suppressWarnings(as.ab(gsub("[ 0-9]", "", x[i], perl = TRUE), loop_time = loop_time + 1))
+        found <- suppressWarnings(as.ab(gsub("[ 0-9]", "", x[i], perl = TRUE), loop_time = loop_time + 2))
         if (length(found) > 0 && !is.na(found)) {
           x_new[i] <- note_if_more_than_one_found(found, i, from_text)
           next
@@ -363,7 +362,7 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
         )[[1]],
         collapse = "/"
       )
-      x_translated_guess <- suppressWarnings(as.ab(x_translated, loop_time = loop_time + 1))
+      x_translated_guess <- suppressWarnings(as.ab(x_translated, loop_time = loop_time + 2))
       if (!is.na(x_translated_guess)) {
         x_new[i] <- x_translated_guess
         next
@@ -375,7 +374,7 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
           strsplit(x_translated, "[^A-Z0-9 ]"),
           function(y) {
             for (i in seq_len(length(y))) {
-              y_name <- suppressWarnings(ab_name(y[i], language = NULL, loop_time = loop_time + 1))
+              y_name <- suppressWarnings(ab_name(y[i], language = NULL, loop_time = loop_time + 2))
               y[i] <- ifelse(!is.na(y_name),
                 y_name,
                 y[i]
@@ -386,7 +385,7 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
         )[[1]],
         collapse = "/"
       )
-      x_translated_guess <- suppressWarnings(as.ab(x_translated, loop_time = loop_time + 1))
+      x_translated_guess <- suppressWarnings(as.ab(x_translated, loop_time = loop_time + 2))
       if (!is.na(x_translated_guess)) {
         x_new[i] <- x_translated_guess
         next
@@ -394,7 +393,7 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
 
       # try by removing all trailing capitals
       if (x[i] %like_case% "[a-z]+[A-Z]+$") {
-        found <- suppressWarnings(as.ab(gsub("[A-Z]+$", "", x[i], perl = TRUE), loop_time = loop_time + 1))
+        found <- suppressWarnings(as.ab(gsub("[A-Z]+$", "", x[i], perl = TRUE), loop_time = loop_time + 2))
         if (!is.na(found)) {
           x_new[i] <- note_if_more_than_one_found(found, i, from_text)
           next
@@ -402,7 +401,7 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
       }
 
       # keep only letters
-      found <- suppressWarnings(as.ab(gsub("[^A-Z]", "", x[i], perl = TRUE), loop_time = loop_time + 1))
+      found <- suppressWarnings(as.ab(gsub("[^A-Z]", "", x[i], perl = TRUE), loop_time = loop_time + 2))
       if (!is.na(found)) {
         x_new[i] <- note_if_more_than_one_found(found, i, from_text)
         next
@@ -413,7 +412,7 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
       if (flag_multiple_results == TRUE) {
         found <- from_text[1L]
       } else {
-        found <- tryCatch(suppressWarnings(ab_from_text(x[i], loop_time = loop_time + 1, translate_ab = FALSE)[[1]][1L]),
+        found <- tryCatch(suppressWarnings(ab_from_text(x[i], loop_time = loop_time + 2, translate_ab = FALSE)[[1]][1L]),
           error = function(e) NA_character_
         )
       }
@@ -423,12 +422,12 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
       }
 
       # first 5 except for cephalosporins, then first 7 (those cephalosporins all start quite the same!)
-      found <- suppressWarnings(as.ab(substr(x[i], 1, 5), loop_time = loop_time + 1))
+      found <- suppressWarnings(as.ab(substr(x[i], 1, 5), loop_time = loop_time + 2))
       if (!is.na(found) && ab_group(found, loop_time = loop_time + 1) %unlike% "cephalosporins") {
         x_new[i] <- note_if_more_than_one_found(found, i, from_text)
         next
       }
-      found <- suppressWarnings(as.ab(substr(x[i], 1, 7), loop_time = loop_time + 1))
+      found <- suppressWarnings(as.ab(substr(x[i], 1, 7), loop_time = loop_time + 2))
       if (!is.na(found)) {
         x_new[i] <- note_if_more_than_one_found(found, i, from_text)
         next
@@ -436,7 +435,7 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
 
       # make all consonants facultative
       search_str <- gsub("([BCDFGHJKLMNPQRSTVWXZ])", "\\1*", x[i], perl = TRUE)
-      found <- suppressWarnings(as.ab(search_str, loop_time = loop_time + 1, already_regex = TRUE))
+      found <- suppressWarnings(as.ab(search_str, loop_time = loop_time + 2, already_regex = TRUE))
       # keep at least 4 normal characters
       if (nchar(gsub(".\\*", "", search_str, perl = TRUE)) < 4) {
         found <- NA
@@ -448,7 +447,7 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
 
       # make all vowels facultative
       search_str <- gsub("([AEIOUY])", "\\1*", x[i], perl = TRUE)
-      found <- suppressWarnings(as.ab(search_str, loop_time = loop_time + 1, already_regex = TRUE))
+      found <- suppressWarnings(as.ab(search_str, loop_time = loop_time + 2, already_regex = TRUE))
       # keep at least 5 normal characters
       if (nchar(gsub(".\\*", "", search_str, perl = TRUE)) < 5) {
         found <- NA
@@ -464,7 +463,7 @@ as.ab <- function(x, flag_multiple_results = TRUE, info = interactive(), ...) {
       x_spelling <- gsub("I+", "[AEIOU]+", x_spelling, fixed = TRUE)
       x_spelling <- gsub("O+", "[AEIOU]+", x_spelling, fixed = TRUE)
       x_spelling <- gsub("U+", "[AEIOU]+", x_spelling, fixed = TRUE)
-      found <- suppressWarnings(as.ab(x_spelling, loop_time = loop_time + 1, already_regex = TRUE))
+      found <- suppressWarnings(as.ab(x_spelling, loop_time = loop_time + 2, already_regex = TRUE))
       if (!is.na(found)) {
         x_new[i] <- note_if_more_than_one_found(found, i, from_text)
         next
diff --git a/R/ab_from_text.R b/R/ab_from_text.R
index 43336c80f..f2d7469a6 100755
--- a/R/ab_from_text.R
+++ b/R/ab_from_text.R
@@ -129,6 +129,10 @@ ab_from_text <- function(text,
       text_split_all <- text_split_all[nchar(text_split_all) >= 4 & grepl("[a-z]+", text_split_all)]
       result <- lapply(text_split_all, function(text_split) {
         progress$tick()
+        text_split <- text_split[text_split %like% "[A-Z]" & text_split %unlike% "[0-9]"]
+        if (length(text_split) == 0) {
+          return(as.ab(NA_character_))
+        }
         suppressWarnings(
           as.ab(text_split, ...)
         )
diff --git a/R/count.R b/R/count.R
index b58179960..772ff43b7 100755
--- a/R/count.R
+++ b/R/count.R
@@ -135,7 +135,7 @@ count_resistant <- function(..., only_all_tested = FALSE) {
 count_susceptible <- function(..., only_all_tested = FALSE) {
   tryCatch(
     sir_calc(...,
-      ab_result = c("S", "I"),
+      ab_result = c("S", "SDD", "I"),
       only_all_tested = only_all_tested,
       only_count = TRUE
     ),
diff --git a/R/sir.R b/R/sir.R
index 1f3146356..d5ab34d72 100755
--- a/R/sir.R
+++ b/R/sir.R
@@ -39,8 +39,8 @@
 #' All breakpoints used for interpretation are available in our [clinical_breakpoints] data set.
 #' @rdname as.sir
 #' @param x vector of values (for class [`mic`]: MIC values in mg/L, for class [`disk`]: a disk diffusion radius in millimetres)
-#' @param mo any (vector of) text that can be coerced to valid microorganism codes with [as.mo()], can be left empty to determine it automatically
-#' @param ab any (vector of) text that can be coerced to a valid antimicrobial drug code with [as.ab()]
+#' @param mo a vector (or column name) with [character]s that can be coerced to valid microorganism codes with [as.mo()], can be left empty to determine it automatically
+#' @param ab a vector (or column name) with [character]s that can be coerced to a valid antimicrobial drug code with [as.ab()]
 #' @param uti (Urinary Tract Infection) A vector with [logical]s (`TRUE` or `FALSE`) to specify whether a UTI specific interpretation from the guideline should be chosen. For using [as.sir()] on a [data.frame], this can also be a column containing [logical]s or when left blank, the data set will be searched for a column 'specimen', and rows within this column containing 'urin' (such as 'urine', 'urina') will be regarded isolates from a UTI. See *Examples*.
 #' @inheritParams first_isolate
 #' @param guideline defaults to EUCAST `r  max(as.integer(gsub("[^0-9]", "", subset(AMR::clinical_breakpoints, guideline %like% "EUCAST")$guideline)))` (the latest implemented EUCAST guideline in the [AMR::clinical_breakpoints] data set), but can be set with the [package option][AMR-options] [`AMR_guideline`][AMR-options]. Currently supports EUCAST (`r min(as.integer(gsub("[^0-9]", "", subset(AMR::clinical_breakpoints, guideline %like% "EUCAST")$guideline)))`-`r max(as.integer(gsub("[^0-9]", "", subset(AMR::clinical_breakpoints, guideline %like% "EUCAST")$guideline)))`) and CLSI (`r min(as.integer(gsub("[^0-9]", "", subset(AMR::clinical_breakpoints, guideline %like% "CLSI")$guideline)))`-`r max(as.integer(gsub("[^0-9]", "", subset(AMR::clinical_breakpoints, guideline %like% "CLSI")$guideline)))`), see *Details*.
@@ -191,7 +191,7 @@
 #'   df %>% mutate(across(AMP:TOB, as.sir))
 #'
 #'   df %>%
-#'     mutate_at(vars(AMP:TOB), as.sir, mo = .$microorganism)
+#'     mutate_at(vars(AMP:TOB), as.sir, mo = "microorganism")
 #'
 #'   # to include information about urinary tract infections (UTI)
 #'   data.frame(
@@ -759,7 +759,7 @@ as_sir_method <- function(method_short,
                           ...) {
   meet_criteria(x, allow_NA = TRUE, .call_depth = -2)
   meet_criteria(mo, allow_class = c("mo", "character"), allow_NULL = TRUE, .call_depth = -2)
-  meet_criteria(ab, allow_class = c("ab", "character"), has_length = 1, .call_depth = -2)
+  meet_criteria(ab, allow_class = c("ab", "character"), .call_depth = -2)
   meet_criteria(guideline, allow_class = "character", has_length = 1, .call_depth = -2)
   meet_criteria(uti, allow_class = "logical", has_length = c(1, length(x)), allow_NULL = TRUE, allow_NA = TRUE, .call_depth = -2)
   meet_criteria(conserve_capped_values, allow_class = "logical", has_length = 1, .call_depth = -2)
@@ -808,37 +808,49 @@ as_sir_method <- function(method_short,
     message_("Please note that in the absence of specific veterinary breakpoints for certain animal hosts, breakpoints for dogs, cattle, swine, cats, horse, aquatic, and poultry, in that order, are used as substitutes.\n\n")
   }
   
-  # for dplyr's across()
-  cur_column_dplyr <- import_fn("cur_column", "dplyr", error_on_fail = FALSE)
-  if (!is.null(cur_column_dplyr) && tryCatch(is.data.frame(get_current_data("ab", call = 0)), error = function(e) FALSE)) {
-    # try to get current column, which will only be available when in across()
-    ab <- tryCatch(cur_column_dplyr(),
-      error = function(e) ab
-    )
-  }
+  current_df <- tryCatch(get_current_data(NA, 0), error = function(e) NULL)
 
-  # for auto-determining mo
-  mo_var_found <- ""
-  if (is.null(mo)) {
-    tryCatch(
-      {
-        df <- get_current_data(arg_name = "mo", call = -3) # will return an error if not found
-        mo <- NULL
-        try(
-          {
-            mo <- suppressMessages(search_type_in_df(df, "mo"))
-          },
-          silent = TRUE
-        )
-        if (!is.null(df) && !is.null(mo) && is.data.frame(df)) {
-          mo_var_found <- paste0(" based on column '", font_bold(mo), "'")
-          mo <- df[, mo, drop = TRUE]
+  # get ab
+  if (!is.null(current_df) && length(ab) == 1 && ab %in% colnames(current_df) && any(current_df[[ab]] %like% "[A-Z]", na.rm = TRUE)) {
+    ab <- current_df[[ab]]
+  } else {
+    # for dplyr's across()
+    cur_column_dplyr <- import_fn("cur_column", "dplyr", error_on_fail = FALSE)
+    if (!is.null(cur_column_dplyr) && is.data.frame(current_df)) {
+      # try to get current column, which will only be available when in across()
+      ab <- tryCatch(cur_column_dplyr(),
+                     error = function(e) ab
+      )
+    }
+  }
+  
+  # get mo
+  if (!is.null(current_df) && length(mo) == 1 && mo %in% colnames(current_df)) {
+    mo_var_found <- paste0(" based on column '", font_bold(mo), "'")
+    mo <- current_df[[mo]]
+  } else {
+    mo_var_found <- ""
+    if (is.null(mo)) {
+      tryCatch(
+        {
+          df <- get_current_data(arg_name = "mo", call = -3) # will return an error if not found
+          mo <- NULL
+          try(
+            {
+              mo <- suppressMessages(search_type_in_df(df, "mo"))
+            },
+            silent = TRUE
+          )
+          if (!is.null(df) && !is.null(mo) && is.data.frame(df)) {
+            mo_var_found <- paste0(" based on column '", font_bold(mo), "'")
+            mo <- df[, mo, drop = TRUE]
+          }
+        },
+        error = function(e) {
+          mo <- NULL
         }
-      },
-      error = function(e) {
-        mo <- NULL
-      }
-    )
+      )
+    }
   }
   if (is.null(mo)) {
     stop_("No information was supplied about the microorganisms (missing argument `mo` and no column of class 'mo' found). See ?as.sir.\n\n",
@@ -861,9 +873,9 @@ as_sir_method <- function(method_short,
   }
   # be sure to take current taxonomy, as the 'clinical_breakpoints' data set only contains current taxonomy
   mo <- suppressWarnings(suppressMessages(as.mo(mo, keep_synonyms = FALSE, info = FALSE)))
-  if (is.na(ab)) {
-    message_("Returning NAs for unknown antibiotic: '", font_bold(ab.bak),
-      "'. Rename this column to a valid name or code, and check the output with `as.ab()`.",
+  if (all(is.na(ab))) {
+    message_("Returning NAs for unknown antibiotic: ", vector_and(ab.bak, sort = FALSE, quotes = TRUE),
+      ". Rename this column to a valid name or code, and check the output with `as.ab()`.",
       add_fn = font_red,
       as_note = FALSE
     )
@@ -887,25 +899,20 @@ as_sir_method <- function(method_short,
     }
   }
 
-  agent_formatted <- paste0("'", font_bold(ab.bak), "'")
+  agent_formatted <- paste0("'", font_bold(ab.bak, collapse = NULL), "'")
   agent_name <- ab_name(ab, tolower = TRUE, language = NULL)
-  if (generalise_antibiotic_name(ab.bak) == generalise_antibiotic_name(agent_name)) {
-    agent_formatted <- paste0(
-      agent_formatted,
-      " (", ab, ")"
-    )
-  } else if (generalise_antibiotic_name(ab) != generalise_antibiotic_name(agent_name)) {
-    agent_formatted <- paste0(
-      agent_formatted,
-      " (", ifelse(ab.bak == ab, "",
-        paste0(ab, ", ")
-      ), agent_name, ")"
-    )
-  }
-  
+  same_ab <- generalise_antibiotic_name(ab) == generalise_antibiotic_name(agent_name)
+  same_ab.bak <- generalise_antibiotic_name(ab.bak) == generalise_antibiotic_name(agent_name)
+  agent_formatted[same_ab.bak] <- paste0(agent_formatted[same_ab.bak], " (", ab, ")")
+  agent_formatted[same_ab.bak & !same_ab] <- paste0(agent_formatted[same_ab.bak & !same_ab], 
+                                                    " (", ifelse(ab.bak[same_ab.bak & !same_ab] == ab[same_ab.bak & !same_ab],
+                                                                 "",
+                                                                 paste0(ab[same_ab.bak & !same_ab], ", ")),
+                                                    agent_name[same_ab.bak & !same_ab],
+                                                    ")")
   # this intro text will also be printed in the progress bar in the `progress` package is installed
   intro_txt <- paste0("Interpreting ", method_long, ": ", ifelse(isTRUE(list(...)$is_data.frame), "column ", ""),
-                      agent_formatted,
+                      ifelse(length(agent_formatted) == 1, agent_formatted, ""),
                       mo_var_found,
                       ifelse(identical(reference_data, AMR::clinical_breakpoints),
                              paste0(", ", font_bold(guideline_coerced)),
@@ -928,23 +935,6 @@ as_sir_method <- function(method_short,
 
   metadata_mo <- get_mo_uncertainties()
 
-  df <- data.frame(
-    values = x,
-    mo = mo,
-    result = NA_sir_,
-    uti = uti,
-    host = host,
-    stringsAsFactors = FALSE
-  )
-  if (method == "mic") {
-    # when as.sir.mic is called directly
-    df$values <- as.mic(df$values)
-  } else if (method == "disk") {
-    # when as.sir.disk is called directly
-    df$values <- as.disk(df$values)
-  }
-  df_unique <- unique(df[ , c("mo", "uti", "host"), drop = FALSE])
-
   rise_warning <- FALSE
   rise_note <- FALSE
   method_coerced <- toupper(method)
@@ -952,20 +942,41 @@ as_sir_method <- function(method_short,
   
   if (identical(reference_data, AMR::clinical_breakpoints)) {
     breakpoints <- reference_data %pm>%
-      subset(guideline == guideline_coerced & method == method_coerced & ab == ab_coerced)
-    if (ab_coerced == "AMX" && nrow(breakpoints) == 0) {
-      ab_coerced <- "AMP"
+      subset(guideline == guideline_coerced & method == method_coerced & ab %in% ab_coerced)
+    if (any(ab_coerced == "AMX") && nrow(breakpoints[breakpoints$ab == "AMX", , drop = FALSE]) == 0) {
+      ab_coerced[ab_coerced == "AMX"] <- "AMP"
       breakpoints <- reference_data %pm>%
-        subset(guideline == guideline_coerced & method == method_coerced & ab == ab_coerced)
+        subset(guideline == guideline_coerced & method == method_coerced & ab %in% ab_coerced)
     }
   } else {
     breakpoints <- reference_data %pm>%
-      subset(method == method_coerced & ab == ab_coerced)
+      subset(method == method_coerced & ab %in% ab_coerced)
   }
-
+  
+  # create the unique data frame to be filled to save time
+  df <- data.frame(
+    values = x,
+    mo = mo,
+    ab = ab,
+    result = NA_sir_,
+    uti = uti,
+    host = host,
+    stringsAsFactors = FALSE
+  )
+  
+  if (method == "mic") {
+    # when as.sir.mic is called directly
+    df$values <- as.mic(df$values)
+  } else if (method == "disk") {
+    # when as.sir.disk is called directly
+    df$values <- as.disk(df$values)
+  }
+  df_unique <- unique(df[ , c("mo", "ab", "uti", "host"), drop = FALSE])
+  
+  # get all breakpoints
   breakpoints <- breakpoints %pm>%
     subset(type == breakpoint_type)
-
+  
   if (isFALSE(include_screening)) {
     # remove screening rules from the breakpoints table
     breakpoints <- breakpoints %pm>%
@@ -1003,6 +1014,7 @@ as_sir_method <- function(method_short,
   for (i in seq_len(nrow(df_unique))) {
     p$tick()
     mo_current <- df_unique[i, "mo", drop = TRUE]
+    ab_current <- df_unique[i, "ab", drop = TRUE]
     uti_current <- df_unique[i, "uti", drop = TRUE]
     if (is.na(uti_current)) {
       # no preference, so no filter on UTIs
@@ -1030,16 +1042,17 @@ as_sir_method <- function(method_short,
     # formatted for notes
     mo_formatted <- mo_current_name
     if (!mo_current_rank %in% c("kingdom", "phylum", "class", "order")) {
-      mo_formatted <- font_italic(mo_formatted)
+      mo_formatted <- font_italic(mo_formatted, collapse = NULL)
     }
     ab_formatted <- paste0(
-      suppressMessages(suppressWarnings(ab_name(ab_coerced, language = NULL, tolower = TRUE))),
-      " (", ab_coerced, ")"
+      suppressMessages(suppressWarnings(ab_name(ab_current, language = NULL, tolower = TRUE))),
+      " (", ab_current, ")"
     )
     
    
     # gather all available breakpoints for current MO
     breakpoints_current <- breakpoints %pm>%
+      subset(ab == ab_current) %pm>%
       subset(mo %in% c(
         mo_current, mo_current_genus, mo_current_family,
         mo_current_order, mo_current_class,
@@ -1155,9 +1168,9 @@ as_sir_method <- function(method_short,
         data.frame(
           datetime = rep(Sys.time(), length(rows)),
           index = rows,
-          ab_user = rep(ab.bak, length(rows)),
+          ab_user = rep(ab.bak[match(ab_current, df$ab)][1], length(rows)),
           mo_user = rep(mo.bak[match(mo_current, df$mo)][1], length(rows)),
-          ab = rep(ab_coerced, length(rows)),
+          ab = rep(ab_current, length(rows)),
           mo = rep(breakpoints_current[, "mo", drop = TRUE], length(rows)),
           input = as.double(values),
           outcome = as.sir(new_sir),
diff --git a/R/sir_calc.R b/R/sir_calc.R
index ec30b45d7..8a962dc51 100755
--- a/R/sir_calc.R
+++ b/R/sir_calc.R
@@ -135,13 +135,20 @@ sir_calc <- function(...,
 
     x_transposed <- as.list(as.data.frame(t(x), stringsAsFactors = FALSE))
     if (isTRUE(only_all_tested)) {
+      get_integers <- function(x) {
+        ints <- rep(NA_integer_, length(x))
+        ints[x == "S"] <- 1L
+        ints[x %in% c("SDD", "I")] <- 2L
+        ints[x == "R"] <- 3L
+        ints
+      }
       # no NAs in any column
       y <- apply(
-        X = as.data.frame(lapply(x, as.integer), stringsAsFactors = FALSE),
+        X = as.data.frame(lapply(x, get_integers), stringsAsFactors = FALSE),
         MARGIN = 1,
         FUN = min
       )
-      numerator <- sum(as.integer(y) %in% as.integer(ab_result), na.rm = TRUE)
+      numerator <- sum(!is.na(y) & y %in% get_integers(ab_result), na.rm = TRUE)
       denominator <- sum(vapply(FUN.VALUE = logical(1), x_transposed, function(y) !(anyNA(y))))
     } else {
       # may contain NAs in any column
@@ -359,6 +366,8 @@ sir_calc_df <- function(type, # "proportion", "count" or "both"
     # the same data structure as output, regardless of input
     out$interpretation <- factor(out$interpretation, levels = c("S", "SDD", "I", "R", "N"), ordered = TRUE)
   }
+  
+  out <- out[!is.na(out$interpretation), , drop = FALSE]
 
   if (data_has_groups) {
     # ordering by the groups and two more: "antibiotic" and "interpretation"
diff --git a/inst/tinytest/test-count.R b/inst/tinytest/test-count.R
index 604ac3071..ea82baa51 100644
--- a/inst/tinytest/test-count.R
+++ b/inst/tinytest/test-count.R
@@ -69,7 +69,7 @@ if (AMR:::pkg_is_available("dplyr", min_version = "1.0.0", also_load = TRUE)) {
     example_isolates %>% count_susceptible(AMC, GEN, only_all_tested = TRUE) +
       example_isolates %>% count_resistant(AMC, GEN, only_all_tested = TRUE)
   )
-
+  
   # count of cases
   expect_equal(
     example_isolates %>%
@@ -95,8 +95,10 @@ if (AMR:::pkg_is_available("dplyr", min_version = "1.0.0", also_load = TRUE)) {
     example_isolates %>% select(AMX) %>% count_df(combine_SI = FALSE) %>% pull(value),
     c(
       suppressWarnings(example_isolates$AMX %>% count_S()),
+      0,
       example_isolates$AMX %>% count_I(),
-      example_isolates$AMX %>% count_R()
+      example_isolates$AMX %>% count_R(),
+      0
     )
   )
 
diff --git a/man/as.sir.Rd b/man/as.sir.Rd
index 8e2ae050f..1a468a2a0 100644
--- a/man/as.sir.Rd
+++ b/man/as.sir.Rd
@@ -98,9 +98,9 @@ sir_interpretation_history(clean = FALSE)
 
 \item{S, I, R, N, SDD}{a case-indepdendent \link[base:regex]{regular expression} to translate input to this result. This regular expression will be run \emph{after} all non-letters are removed from the input.}
 
-\item{mo}{any (vector of) text that can be coerced to valid microorganism codes with \code{\link[=as.mo]{as.mo()}}, can be left empty to determine it automatically}
+\item{mo}{a vector (or column name) with \link{character}s that can be coerced to valid microorganism codes with \code{\link[=as.mo]{as.mo()}}, can be left empty to determine it automatically}
 
-\item{ab}{any (vector of) text that can be coerced to a valid antimicrobial drug code with \code{\link[=as.ab]{as.ab()}}}
+\item{ab}{a vector (or column name) with \link{character}s that can be coerced to a valid antimicrobial drug code with \code{\link[=as.ab]{as.ab()}}}
 
 \item{guideline}{defaults to EUCAST 2023 (the latest implemented EUCAST guideline in the \link{clinical_breakpoints} data set), but can be set with the \link[=AMR-options]{package option} \code{\link[=AMR-options]{AMR_guideline}}. Currently supports EUCAST (2011-2023) and CLSI (2011-2023), see \emph{Details}.}
 
@@ -284,7 +284,7 @@ if (require("dplyr")) {
   df \%>\% mutate(across(AMP:TOB, as.sir))
 
   df \%>\%
-    mutate_at(vars(AMP:TOB), as.sir, mo = .$microorganism)
+    mutate_at(vars(AMP:TOB), as.sir, mo = "microorganism")
 
   # to include information about urinary tract infections (UTI)
   data.frame(