# ==================================================================== # # TITLE # # Antimicrobial Resistance (AMR) Data Analysis for R # # # # SOURCE # # https://github.com/msberends/AMR # # # # LICENCE # # (c) 2018-2022 Berends MS, Luz CF et al. # # Developed at the University of Groningen, the Netherlands, in # # collaboration with non-profit organisations Certe Medical # # Diagnostics & Advice, and University Medical Center Groningen. # # # # This R package is free software; you can freely use and distribute # # it for both personal and commercial purposes under the terms of the # # GNU General Public License version 2.0 (GNU GPL-2), as published by # # the Free Software Foundation. # # We created this package for both routine data analysis and academic # # research and it was publicly released in the hope that it will be # # useful, but it comes WITHOUT ANY WARRANTY OR LIABILITY. # # # # Visit our website for the full manual and a complete tutorial about # # how to conduct AMR data analysis: https://msberends.github.io/AMR/ # # ==================================================================== # #' Calculate the Matching Score for Microorganisms #' #' This algorithm is used by [as.mo()] and all the [`mo_*`][mo_property()] functions to determine the most probable match of taxonomic records based on user input. #' @author Dr. Matthijs Berends #' @param x Any user input value(s) #' @param n A full taxonomic name, that exists in [`microorganisms$fullname`][microorganisms] #' @section Matching Score for Microorganisms: #' With ambiguous user input in [as.mo()] and all the [`mo_*`][mo_property()] functions, the returned results are chosen based on their matching score using [mo_matching_score()]. This matching score \eqn{m}, is calculated as: #' #' \ifelse{latex}{\deqn{m_{(x, n)} = \frac{l_{n} - 0.5 \cdot \min \begin{cases}l_{n} \\ \textrm{lev}(x, n)\end{cases}}{l_{n} \cdot p_{n} \cdot k_{n}}}}{\ifelse{html}{\figure{mo_matching_score.png}{options: width="300" alt="mo matching score"}}{m(x, n) = ( l_n * min(l_n, lev(x, n) ) ) / ( l_n * p_n * k_n )}} #' #' where: #' #' * \ifelse{html}{\out{x is the user input;}}{\eqn{x} is the user input;} #' * \ifelse{html}{\out{n is a taxonomic name (genus, species, and subspecies);}}{\eqn{n} is a taxonomic name (genus, species, and subspecies);} #' * \ifelse{html}{\out{ln is the length of n;}}{l_n is the length of \eqn{n};} #' * \ifelse{html}{\out{lev is the Levenshtein distance function, which counts any insertion, deletion and substitution as 1 that is needed to change x into n;}}{lev is the Levenshtein distance function, which counts any insertion, deletion and substitution as 1 that is needed to change \eqn{x} into \eqn{n};} #' * \ifelse{html}{\out{pn is the human pathogenic prevalence group of n, as described below;}}{p_n is the human pathogenic prevalence group of \eqn{n}, as described below;} #' * \ifelse{html}{\out{kn is the taxonomic kingdom of n, set as Bacteria = 1, Fungi = 2, Protozoa = 3, Archaea = 4, others = 5.}}{l_n is the taxonomic kingdom of \eqn{n}, set as Bacteria = 1, Fungi = 2, Protozoa = 3, Archaea = 4, others = 5.} #' #' The grouping into human pathogenic prevalence (\eqn{p}) is based on experience from several microbiological laboratories in the Netherlands in conjunction with international reports on pathogen prevalence: #' #' **Group 1** (most prevalent microorganisms) consists of all microorganisms where the taxonomic class is Gammaproteobacteria or where the taxonomic genus is *Enterococcus*, *Staphylococcus* or *Streptococcus*. This group consequently contains all common Gram-negative bacteria, such as *Pseudomonas* and *Legionella* and all species within the order Enterobacterales. #' #' **Group 2** consists of all microorganisms where the taxonomic phylum is Proteobacteria, Firmicutes, Actinobacteria or Sarcomastigophora, or where the taxonomic genus is `r vector_or(MO_PREVALENT_GENERA, quotes = "*")`. #' #' **Group 3** consists of all other microorganisms. #' #' All characters in \eqn{x} and \eqn{n} are ignored that are other than A-Z, a-z, 0-9, spaces and parentheses. #' #' All matches are sorted descending on their matching score and for all user input values, the top match will be returned. This will lead to the effect that e.g., `"E. coli"` will return the microbial ID of *Escherichia coli* (\eqn{m = `r round(mo_matching_score("E. coli", "Escherichia coli"), 3)`}, a highly prevalent microorganism found in humans) and not *Entamoeba coli* (\eqn{m = `r round(mo_matching_score("E. coli", "Entamoeba coli"), 3)`}, a less prevalent microorganism in humans), although the latter would alphabetically come first. #' @export #' @inheritSection AMR Reference Data Publicly Available #' @examples #' as.mo("E. coli") #' mo_uncertainties() #' #' mo_matching_score( #' x = "E. coli", #' n = c("Escherichia coli", "Entamoeba coli") #' ) mo_matching_score <- function(x, n) { meet_criteria(x, allow_class = c("character", "data.frame", "list")) meet_criteria(n, allow_class = "character") x <- parse_and_convert(x) # no dots and other non-whitespace characters x <- gsub("[^a-zA-Z0-9 \\(\\)]+", "", x) # only keep one space x <- gsub(" +", " ", x) # n is always a taxonomically valid full name if (length(n) == 1) { n <- rep(n, length(x)) } if (length(x) == 1) { x <- rep(x, length(n)) } # length of fullname l_n <- nchar(n) lev <- double(length = length(x)) l_n.lev <- double(length = length(x)) lev <- unlist(Map( f = utils::adist, x, n, ignore.case = FALSE, USE.NAMES = FALSE, fixed = TRUE )) l_n.lev[l_n < lev] <- l_n[l_n < lev] l_n.lev[lev < l_n] <- lev[lev < l_n] l_n.lev[lev == l_n] <- lev[lev == l_n] # human pathogenic prevalence (1 to 3), see ?as.mo p_n <- MO_lookup[match(n, MO_lookup$fullname), "prevalence", drop = TRUE] # kingdom index (Bacteria = 1, Fungi = 2, Protozoa = 3, Archaea = 4, others = 5) k_n <- MO_lookup[match(n, MO_lookup$fullname), "kingdom_index", drop = TRUE] # matching score: (l_n - 0.5 * l_n.lev) / (l_n * p_n * k_n) }