(Key) Antimicrobials for First Weighted Isolates

These functions can be used to determine first weighted isolates by considering the phenotype for isolate selection (see first_isolate()). Using a phenotype-based method to determine first isolates is more reliable than methods that disregard phenotypes.

key_antimicrobials(
  x = NULL,
  col_mo = NULL,
  universal = c("ampicillin", "amoxicillin/clavulanic acid", "cefuroxime",
    "piperacillin/tazobactam", "ciprofloxacin", "trimethoprim/sulfamethoxazole"),
  gram_negative = c("gentamicin", "tobramycin", "colistin", "cefotaxime",
    "ceftazidime", "meropenem"),
  gram_positive = c("vancomycin", "teicoplanin", "tetracycline", "erythromycin",
    "oxacillin", "rifampin"),
  antifungal = c("anidulafungin", "caspofungin", "fluconazole", "miconazole",
    "nystatin", "voriconazole"),
  only_rsi_columns = FALSE,
  ...
)

all_antimicrobials(x = NULL, only_rsi_columns = FALSE, ...)

antimicrobials_equal(
  y,
  z,
  type = c("points", "keyantimicrobials"),
  ignore_I = TRUE,
  points_threshold = 2,
  ...
)

Arguments

x: a data.frame with antibiotics columns, like AMX or amox. Can be left blank to determine automatically
col_mo: column name of the IDs of the microorganisms (see as.mo()), defaults to the first column of class mo. Values will be coerced using as.mo().
universal: names of broad-spectrum antimicrobial agents, case-insensitive. Set to NULL to ignore. See Details for the default agents.
gram_negative: names of antibiotic agents for Gram-positives, case-insensitive. Set to NULL to ignore. See Details for the default agents.
gram_positive: names of antibiotic agents for Gram-negatives, case-insensitive. Set to NULL to ignore. See Details for the default agents.
antifungal: names of antifungal agents for fungi, case-insensitive. Set to NULL to ignore. See Details for the default agents.
only_rsi_columns: a logical to indicate whether only columns must be included that were transformed to class <rsi> (see as.rsi()) on beforehand (defaults to FALSE)
...: ignored, only in place to allow future extensions
y, z: character vectors to compare
type: type to determine weighed isolates; can be "keyantimicrobials" or "points", see Details
ignore_I: logical to indicate whether antibiotic interpretations with "I" will be ignored when type = "keyantimicrobials", see Details
points_threshold: minimum number of points to require before differences in the antibiogram will lead to inclusion of an isolate when type = "points", see Details

Details

The key_antimicrobials() and all_antimicrobials() functions are context-aware. This means that the x argument can be left blank if used inside a data.frame call, see Examples.

The function key_antimicrobials() returns a character vector with 12 antimicrobial results for every isolate. The function all_antimicrobials() returns a character vector with all antimicrobial results for every isolate. These vectors can then be compared using antimicrobials_equal(), to check if two isolates have generally the same antibiogram. Missing and invalid values are replaced with a dot (".") by key_antimicrobials() and ignored by antimicrobials_equal().

Please see the first_isolate() function how these important functions enable the 'phenotype-based' method for determination of first isolates.

The default antimicrobial agents used for all rows (set in universal) are:

Ampicillin
Amoxicillin/clavulanic acid
Cefuroxime
Ciprofloxacin
Piperacillin/tazobactam
Trimethoprim/sulfamethoxazole

The default antimicrobial agents used for Gram-negative bacteria (set in gram_negative) are:

Cefotaxime
Ceftazidime
Colistin
Gentamicin
Meropenem
Tobramycin

The default antimicrobial agents used for Gram-positive bacteria (set in gram_positive) are:

Erythromycin
Oxacillin
Rifampin
Teicoplanin
Tetracycline
Vancomycin

The default antimicrobial agents used for fungi (set in antifungal) are:

Anidulafungin
Caspofungin
Fluconazole
Miconazole
Nystatin
Voriconazole

Stable Lifecycle

The lifecycle of this function is stable. In a stable function, major changes are unlikely. This means that the unlying code will generally evolve by adding new arguments; removing arguments or changing the meaning of existing arguments will be avoided.

If the unlying code needs breaking changes, they will occur gradually. For example, an argument will be deprecated and first continue to work, but will emit a message informing you of the change. Next, typically after at least one newly released version on CRAN, the message will be transformed to an error.

Examples

# `example_isolates` is a data set available in the AMR package.
# See ?example_isolates.

# output of the `key_antimicrobials()` function could be like this:
strainA <- "SSSRR.S.R..S"
strainB <- "SSSIRSSSRSSS"

# those strings can be compared with:
antimicrobials_equal(strainA, strainB, type = "keyantimicrobials")
# TRUE, because I is ignored (as well as missing values)

antimicrobials_equal(strainA, strainB, type = "keyantimicrobials", ignore_I = FALSE)
# FALSE, because I is not ignored and so the 4th [character] differs

# \donttest{
if (require("dplyr")) {
  # set key antibiotics to a new variable
  my_patients <- example_isolates %>%
    mutate(keyab = key_antimicrobials(antifungal = NULL)) %>% # no need to define `x`
    mutate(
      # now calculate first isolates
      first_regular = first_isolate(col_keyantimicrobials = FALSE),
      # and first WEIGHTED isolates
      first_weighted = first_isolate(col_keyantimicrobials = "keyab")
    )
 
  # Check the difference, in this data set it results in more isolates:
  sum(my_patients$first_regular, na.rm = TRUE)
  sum(my_patients$first_weighted, na.rm = TRUE)
}
# }

Arguments

Details

Stable Lifecycle

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See also

Examples