These functions determine which items in a vector can be considered (the start of) a new episode, based on the argument episode_days. This can be used to determine clinical episodes for any epidemiological analysis. The get_episode() function returns the index number of the episode per group, while the is_new_episode() function returns values TRUE/FALSE to indicate whether an item in a vector is the start of a new episode.
Arguments
- x
vector of dates (class
DateorPOSIXt), will be sorted internally to determine episodes- episode_days
required episode length in days, can also be less than a day or
Inf, see Details- ...
ignored, only in place to allow future extensions
Details
Dates are first sorted from old to new. The oldest date will mark the start of the first episode. After this date, the next date will be marked that is at least episode_days days later than the start of the first episode. From that second marked date on, the next date will be marked that is at least episode_days days later than the start of the second episode which will be the start of the third episode, and so on. Before the vector is being returned, the original order will be restored.
The first_isolate() function is a wrapper around the is_new_episode() function, but is more efficient for data sets containing microorganism codes or names and allows for different isolate selection methods.
The dplyr package is not required for these functions to work, but these functions do support variable grouping and work conveniently inside dplyr verbs such as filter(), mutate() and summarise().
Examples
# `example_isolates` is a data set available in the AMR package.
# See ?example_isolates
df <- example_isolates[sample(seq_len(2000), size = 200), ]
get_episode(df$date, episode_days = 60) # indices
#> [1] 56 61 60 30 16 51 17 7 8 2 14 22 30 19 38 31 30 47 27 23 10 58 41 64 15
#> [26] 39 9 28 40 35 37 57 4 10 29 61 53 2 56 27 56 13 62 28 46 9 45 43 4 16
#> [51] 53 52 6 18 35 57 8 48 10 18 11 26 31 40 34 17 19 18 32 17 1 39 9 5 25
#> [76] 5 51 52 33 45 14 4 12 6 38 62 7 9 9 45 49 40 33 30 12 13 4 47 39 60
#> [101] 60 20 8 2 13 51 57 62 36 38 34 38 14 16 1 54 42 28 59 23 29 3 36 43 8
#> [126] 27 9 48 1 40 9 24 57 22 59 33 7 30 7 60 32 37 36 13 35 10 32 49 41 62
#> [151] 30 8 19 26 44 24 46 63 47 56 54 22 33 50 30 55 49 12 55 57 50 24 9 54 27
#> [176] 30 40 26 58 39 9 58 25 13 60 21 44 39 26 28 41 29 35 10 18 3 46 38 61 20
is_new_episode(df$date, episode_days = 60) # TRUE/FALSE
#> [1] FALSE TRUE TRUE TRUE FALSE FALSE FALSE FALSE FALSE TRUE FALSE TRUE
#> [13] FALSE FALSE FALSE TRUE FALSE FALSE FALSE TRUE FALSE FALSE FALSE TRUE
#> [25] TRUE FALSE FALSE FALSE FALSE FALSE TRUE FALSE FALSE FALSE FALSE FALSE
#> [37] TRUE FALSE FALSE TRUE TRUE FALSE FALSE FALSE TRUE FALSE FALSE FALSE
#> [49] TRUE FALSE FALSE TRUE TRUE TRUE FALSE TRUE FALSE FALSE TRUE FALSE
#> [61] TRUE FALSE FALSE TRUE FALSE FALSE TRUE FALSE FALSE TRUE TRUE FALSE
#> [73] FALSE FALSE FALSE TRUE TRUE FALSE FALSE TRUE TRUE FALSE TRUE FALSE
#> [85] TRUE FALSE TRUE FALSE FALSE FALSE FALSE FALSE TRUE FALSE FALSE FALSE
#> [97] FALSE FALSE TRUE FALSE FALSE TRUE FALSE FALSE TRUE FALSE FALSE TRUE
#> [109] TRUE FALSE TRUE FALSE FALSE TRUE FALSE FALSE TRUE TRUE TRUE FALSE
#> [121] TRUE TRUE FALSE TRUE TRUE FALSE TRUE TRUE FALSE FALSE FALSE FALSE
#> [133] FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE FALSE
#> [145] FALSE FALSE TRUE TRUE TRUE FALSE FALSE FALSE FALSE FALSE TRUE TRUE
#> [157] FALSE TRUE TRUE FALSE TRUE FALSE FALSE FALSE FALSE TRUE FALSE FALSE
#> [169] FALSE FALSE TRUE FALSE FALSE FALSE FALSE FALSE FALSE TRUE TRUE FALSE
#> [181] FALSE FALSE TRUE FALSE FALSE TRUE FALSE FALSE FALSE FALSE FALSE FALSE
#> [193] TRUE FALSE FALSE FALSE FALSE FALSE FALSE FALSE
# filter on results from the third 60-day episode only, using base R
df[which(get_episode(df$date, 60) == 3), ]
#> # A tibble: 2 × 46
#> date patient age gender ward mo PEN OXA FLC AMX
#> <date> <chr> <dbl> <chr> <chr> <mo> <rsi> <rsi> <rsi> <rsi>
#> 1 2002-08-19 A49852 70 M Clinical B_ESCHR_COLI R NA NA NA
#> 2 2002-10-14 FCC668 54 F ICU B_STRPT_PNMN S NA NA S
#> # … with 36 more variables: AMC <rsi>, AMP <rsi>, TZP <rsi>, CZO <rsi>,
#> # FEP <rsi>, CXM <rsi>, FOX <rsi>, CTX <rsi>, CAZ <rsi>, CRO <rsi>,
#> # GEN <rsi>, TOB <rsi>, AMK <rsi>, KAN <rsi>, TMP <rsi>, SXT <rsi>,
#> # NIT <rsi>, FOS <rsi>, LNZ <rsi>, CIP <rsi>, MFX <rsi>, VAN <rsi>,
#> # TEC <rsi>, TCY <rsi>, TGC <rsi>, DOX <rsi>, ERY <rsi>, CLI <rsi>,
#> # AZM <rsi>, IPM <rsi>, MEM <rsi>, MTR <rsi>, CHL <rsi>, COL <rsi>,
#> # MUP <rsi>, RIF <rsi>
# the functions also work for less than a day, e.g. to include one per hour:
get_episode(c(
Sys.time(),
Sys.time() + 60 * 60
),
episode_days = 1 / 24
)
#> [1] 1 2
# \donttest{
if (require("dplyr")) {
# is_new_episode() can also be used in dplyr verbs to determine patient
# episodes based on any (combination of) grouping variables:
df %>%
mutate(condition = sample(
x = c("A", "B", "C"),
size = 200,
replace = TRUE
)) %>%
group_by(condition) %>%
mutate(new_episode = is_new_episode(date, 365)) %>%
select(patient, date, condition, new_episode)
}
#> # A tibble: 200 × 4
#> # Groups: condition [3]
#> patient date condition new_episode
#> <chr> <date> <chr> <lgl>
#> 1 329C35 2016-04-02 C TRUE
#> 2 694764 2017-03-30 A FALSE
#> 3 4B1971 2017-01-13 A TRUE
#> 4 B65162 2008-12-29 C FALSE
#> 5 B338BC 2005-07-02 B FALSE
#> 6 F67089 2014-10-24 B FALSE
#> 7 969581 2005-10-18 B TRUE
#> 8 F35553 2003-08-13 C FALSE
#> 9 82C90B 2003-09-19 C FALSE
#> 10 D10443 2002-04-26 C FALSE
#> # … with 190 more rows
if (require("dplyr")) {
df %>%
group_by(ward, patient) %>%
transmute(date,
patient,
new_index = get_episode(date, 60),
new_logical = is_new_episode(date, 60)
)
}
#> # A tibble: 200 × 5
#> # Groups: ward, patient [189]
#> ward date patient new_index new_logical
#> <chr> <date> <chr> <dbl> <lgl>
#> 1 Clinical 2016-04-02 329C35 1 TRUE
#> 2 ICU 2017-03-30 694764 1 TRUE
#> 3 ICU 2017-01-13 4B1971 1 TRUE
#> 4 Clinical 2008-12-29 B65162 1 TRUE
#> 5 Clinical 2005-07-02 B338BC 1 TRUE
#> 6 Clinical 2014-10-24 F67089 1 TRUE
#> 7 Clinical 2005-10-18 969581 1 TRUE
#> 8 ICU 2003-08-13 F35553 2 TRUE
#> 9 Clinical 2003-09-19 82C90B 1 TRUE
#> 10 Clinical 2002-04-26 D10443 1 TRUE
#> # … with 190 more rows
if (require("dplyr")) {
df %>%
group_by(ward) %>%
summarise(
n_patients = n_distinct(patient),
n_episodes_365 = sum(is_new_episode(date, episode_days = 365)),
n_episodes_60 = sum(is_new_episode(date, episode_days = 60)),
n_episodes_30 = sum(is_new_episode(date, episode_days = 30))
)
}
#> # A tibble: 3 × 5
#> ward n_patients n_episodes_365 n_episodes_60 n_episodes_30
#> <chr> <int> <int> <int> <int>
#> 1 Clinical 117 14 52 63
#> 2 ICU 59 14 39 50
#> 3 Outpatient 13 8 12 13
if (require("dplyr")) {
# grouping on patients and microorganisms leads to the same
# results as first_isolate() when using 'episode-based':
x <- df %>%
filter_first_isolate(
include_unknown = TRUE,
method = "episode-based"
)
y <- df %>%
group_by(patient, mo) %>%
filter(is_new_episode(date, 365)) %>%
ungroup()
identical(x, y)
}
#> Including isolates from ICU.
#> [1] FALSE
if (require("dplyr")) {
# but is_new_episode() has a lot more flexibility than first_isolate(),
# since you can now group on anything that seems relevant:
df %>%
group_by(patient, mo, ward) %>%
mutate(flag_episode = is_new_episode(date, 365)) %>%
select(group_vars(.), flag_episode)
}
#> # A tibble: 200 × 4
#> # Groups: patient, mo, ward [191]
#> patient mo ward flag_episode
#> <chr> <mo> <chr> <lgl>
#> 1 329C35 B_ESCHR_COLI Clinical TRUE
#> 2 694764 B_STPHY_HMNS ICU TRUE
#> 3 4B1971 B_ESCHR_COLI ICU TRUE
#> 4 B65162 B_STRPT_PNMN Clinical TRUE
#> 5 B338BC B_ENTRC Clinical TRUE
#> 6 F67089 B_STPHY_AURS Clinical TRUE
#> 7 969581 B_STPHY_CONS Clinical TRUE
#> 8 F35553 B_ENTRC_FCLS ICU TRUE
#> 9 82C90B B_STPHY_EPDR Clinical TRUE
#> 10 D10443 B_KLBSL_PNMN Clinical TRUE
#> # … with 190 more rows
# }