Predict antimicrobial resistance

Create a prediction model to predict antimicrobial resistance for the next years on statistical solid ground. Standard errors (SE) will be returned as columns se_min and se_max. See Examples for a real live example.

resistance_predict(tbl, col_ab, col_date, year_min = NULL,
  year_max = NULL, year_every = 1, minimum = 30,
  model = "binomial", I_as_R = TRUE, preserve_measurements = TRUE,
  info = TRUE)

rsi_predict(tbl, col_ab, col_date, year_min = NULL, year_max = NULL,
  year_every = 1, minimum = 30, model = "binomial", I_as_R = TRUE,
  preserve_measurements = TRUE, info = TRUE)

Arguments

tbl	a data.frame containing isolates.
col_ab	column name of tbl with antimicrobial interpretations (R, I and S)
col_date	column name of the date, will be used to calculate years if this column doesn't consist of years already
year_min	lowest year to use in the prediction model, dafaults to the lowest year in col_date
year_max	highest year to use in the prediction model, defaults to 10 years after today
year_every	unit of sequence between lowest year found in the data and year_max
minimum	minimal amount of available isolates per year to include. Years containing less observations will be estimated by the model.
model	the statistical model of choice. Valid values are "binomial" (or "binom" or "logit") or "loglin" or "linear" (or "lin").
I_as_R	a logical to indicate whether values I should be treated as R
preserve_measurements	a logical to indicate whether predictions of years that are actually available in the data should be overwritten by the original data. The standard errors of those years will be NA.
info	a logical to indicate whether textual analysis should be printed with the name and summary of the statistical model.

Value

data.frame with columns:

• year

• value, the same as estimated when preserve_measurements = FALSE, and a combination of observed and estimated otherwise

• se_min, the lower bound of the standard error with a minimum of 0 (so the standard error will never go below 0%)

• se_max the upper bound of the standard error with a maximum of 1 (so the standard error will never go above 100%)

• observations, the total number of available observations in that year, i.e. S + I + R

• observed, the original observed resistant percentages

• estimated, the estimated resistant percentages, calculated by the model

Read more on our website!

On our website https://msberends.gitlab.io/AMR you can find a omprehensive tutorial about how to conduct AMR analysis and find the complete documentation of all functions, which reads a lot easier than in R.

See also

The portion function to calculate resistance,
lm glm

Examples

# NOT RUN {
# use it with base R:
resistance_predict(tbl = tbl[which(first_isolate == TRUE & genus == "Haemophilus"),],
                   col_ab = "amcl", col_date = "date")

# or use dplyr so you can actually read it:
library(dplyr)
tbl %>%
  filter(first_isolate == TRUE,
         genus == "Haemophilus") %>%
  resistance_predict(amcl, date)
# }# NOT RUN {

# real live example:
library(dplyr)
septic_patients %>%
  # get bacteria properties like genus and species
  left_join_microorganisms("mo") %>%
  # calculate first isolates
  mutate(first_isolate = first_isolate(.)) %>%
  # filter on first E. coli isolates
  filter(genus == "Escherichia",
         species == "coli",
         first_isolate == TRUE) %>%
  # predict resistance of cefotaxime for next years
  resistance_predict(col_ab = "cfot",
                     col_date = "date",
                     year_max = 2025,
                     preserve_measurements = TRUE,
                     minimum = 0)

# create nice plots with ggplot
if (!require(ggplot2)) {

  data <- septic_patients %>%
    filter(mo == as.mo("E. coli")) %>%
    resistance_predict(col_ab = "amox",
                       col_date = "date",
                       info = FALSE,
                        minimum = 15)

  ggplot(data,
         aes(x = year)) +
    geom_col(aes(y = value),
             fill = "grey75") +
    geom_errorbar(aes(ymin = se_min,
                      ymax = se_max),
                  colour = "grey50") +
    scale_y_continuous(limits = c(0, 1),
                       breaks = seq(0, 1, 0.1),
                       labels = paste0(seq(0, 100, 10), "%")) +
    labs(title = expression(paste("Forecast of amoxicillin resistance in ",
                                  italic("E. coli"))),
         y = "%IR",
         x = "Year") +
    theme_minimal(base_size = 13)
}
# }