mirror of https://github.com/msberends/AMR.git
1268 lines
60 KiB
R
Executable File
1268 lines
60 KiB
R
Executable File
# ==================================================================== #
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# TITLE: #
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# AMR: An R Package for Working with Antimicrobial Resistance Data #
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# #
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# SOURCE CODE: #
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# https://github.com/msberends/AMR #
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# #
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# PLEASE CITE THIS SOFTWARE AS: #
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# Berends MS, Luz CF, Friedrich AW, Sinha BNM, Albers CJ, Glasner C #
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# (2022). AMR: An R Package for Working with Antimicrobial Resistance #
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# Data. Journal of Statistical Software, 104(3), 1-31. #
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# https://doi.org/10.18637/jss.v104.i03 #
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# #
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# Developed at the University of Groningen and the University Medical #
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# Center Groningen in The Netherlands, in collaboration with many #
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# colleagues from around the world, see our website. #
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# #
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# This R package is free software; you can freely use and distribute #
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# it for both personal and commercial purposes under the terms of the #
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# GNU General Public License version 2.0 (GNU GPL-2), as published by #
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# the Free Software Foundation. #
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# We created this package for both routine data analysis and academic #
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# research and it was publicly released in the hope that it will be #
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# useful, but it comes WITHOUT ANY WARRANTY OR LIABILITY. #
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# #
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# Visit our website for the full manual and a complete tutorial about #
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# how to conduct AMR data analysis: https://msberends.github.io/AMR/ #
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# ==================================================================== #
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#' Transform Arbitrary Input to Valid Microbial Taxonomy
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#'
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#' Use this function to get a valid microorganism code ([`mo`]) based on arbitrary user input. Determination is done using intelligent rules and the complete taxonomic tree of the kingdoms `r vector_and(unique(microorganisms$kingdom[which(!grepl("(unknown|Fungi)", microorganisms$kingdom))]), quotes = FALSE)`, and most microbial species from the kingdom Fungi (see *Source*). The input can be almost anything: a full name (like `"Staphylococcus aureus"`), an abbreviated name (such as `"S. aureus"`), an abbreviation known in the field (such as `"MRSA"`), or just a genus. See *Examples*.
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#' @param x a [character] vector or a [data.frame] with one or two columns
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#' @param Becker a [logical] to indicate whether staphylococci should be categorised into coagulase-negative staphylococci ("CoNS") and coagulase-positive staphylococci ("CoPS") instead of their own species, according to Karsten Becker *et al.* (see *Source*). Please see *Details* for a full list of staphylococcal species that will be converted.
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#'
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#' This excludes *Staphylococcus aureus* at default, use `Becker = "all"` to also categorise *S. aureus* as "CoPS".
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#' @param Lancefield a [logical] to indicate whether a beta-haemolytic *Streptococcus* should be categorised into Lancefield groups instead of their own species, according to Rebecca C. Lancefield (see *Source*). These streptococci will be categorised in their first group, e.g. *Streptococcus dysgalactiae* will be group C, although officially it was also categorised into groups G and L. . Please see *Details* for a full list of streptococcal species that will be converted.
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#'
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#' This excludes enterococci at default (who are in group D), use `Lancefield = "all"` to also categorise all enterococci as group D.
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#' @param minimum_matching_score a numeric value to set as the lower limit for the [MO matching score][mo_matching_score()]. When left blank, this will be determined automatically based on the character length of `x`, its [taxonomic kingdom][microorganisms] and [human pathogenicity][mo_matching_score()].
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#' @param keep_synonyms a [logical] to indicate if old, previously valid taxonomic names must be preserved and not be corrected to currently accepted names. The default is `FALSE`, which will return a note if old taxonomic names were processed. The default can be set with the [package option][AMR-options] [`AMR_keep_synonyms`][AMR-options], i.e. `options(AMR_keep_synonyms = TRUE)` or `options(AMR_keep_synonyms = FALSE)`.
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#' @param reference_df a [data.frame] to be used for extra reference when translating `x` to a valid [`mo`]. See [set_mo_source()] and [get_mo_source()] to automate the usage of your own codes (e.g. used in your analysis or organisation).
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#' @param ignore_pattern a Perl-compatible [regular expression][base::regex] (case-insensitive) of which all matches in `x` must return `NA`. This can be convenient to exclude known non-relevant input and can also be set with the [package option][AMR-options] [`AMR_ignore_pattern`][AMR-options], e.g. `options(AMR_ignore_pattern = "(not reported|contaminated flora)")`.
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#' @param cleaning_regex a Perl-compatible [regular expression][base::regex] (case-insensitive) to clean the input of `x`. Every matched part in `x` will be removed. At default, this is the outcome of [mo_cleaning_regex()], which removes texts between brackets and texts such as "species" and "serovar". The default can be set with the [package option][AMR-options] [`AMR_cleaning_regex`][AMR-options].
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#' @param language language to translate text like "no growth", which defaults to the system language (see [get_AMR_locale()])
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#' @param info a [logical] to indicate if a progress bar should be printed if more than 25 items are to be coerced - the default is `TRUE` only in interactive mode
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#' @param ... other arguments passed on to functions
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#' @rdname as.mo
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#' @aliases mo
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#' @details
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#' A microorganism (MO) code from this package (class: [`mo`]) is human readable and typically looks like these examples:
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#' ```
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#' Code Full name
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#' --------------- --------------------------------------
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#' B_KLBSL Klebsiella
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#' B_KLBSL_PNMN Klebsiella pneumoniae
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#' B_KLBSL_PNMN_RHNS Klebsiella pneumoniae rhinoscleromatis
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#' | | | |
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#' | | | |
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#' | | | \---> subspecies, a 3-5 letter acronym
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#' | | \----> species, a 3-6 letter acronym
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#' | \----> genus, a 4-8 letter acronym
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#' \----> taxonomic kingdom: A (Archaea), AN (Animalia), B (Bacteria),
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#' F (Fungi), PL (Plantae), P (Protozoa)
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#' ```
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#'
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#' Values that cannot be coerced will be considered 'unknown' and will be returned as the MO code `UNKNOWN` with a warning.
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#'
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#' Use the [`mo_*`][mo_property()] functions to get properties based on the returned code, see *Examples*.
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#'
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#' The [as.mo()] function uses a novel [matching score algorithm][mo_matching_score()] (see *Matching Score for Microorganisms* below) to match input against the [available microbial taxonomy][microorganisms] in this package. This will lead to the effect that e.g. `"E. coli"` (a microorganism highly prevalent in humans) will return the microbial ID of *Escherichia coli* and not *Entamoeba coli* (a microorganism less prevalent in humans), although the latter would alphabetically come first.
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#'
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#' With `Becker = TRUE`, the following `r length(MO_CONS[MO_CONS != "B_STPHY_CONS"])` staphylococci will be converted to the **coagulase-negative group**: `r vector_and(gsub("Staphylococcus", "S.", mo_name(MO_CONS[MO_CONS != "B_STPHY_CONS"], keep_synonyms = TRUE)), quotes = "*")`.\cr The following `r length(MO_COPS[MO_COPS != "B_STPHY_COPS"])` staphylococci will be converted to the **coagulase-positive group**: `r vector_and(gsub("Staphylococcus", "S.", mo_name(MO_COPS[MO_COPS != "B_STPHY_COPS"], keep_synonyms = TRUE)), quotes = "*")`.
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#'
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#' With `Lancefield = TRUE`, the following streptococci will be converted to their corresponding Lancefield group: `r vector_and(gsub("Streptococcus", "S.", paste0("*", mo_name(MO_LANCEFIELD, keep_synonyms = TRUE), "* (", mo_species(MO_LANCEFIELD, keep_synonyms = TRUE, Lancefield = TRUE), ")")), quotes = FALSE)`.
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#'
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#' ### Coping with Uncertain Results
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#'
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#' Results of non-exact taxonomic input are based on their [matching score][mo_matching_score()]. The lowest allowed score can be set with the `minimum_matching_score` argument. At default this will be determined based on the character length of the input, and the [taxonomic kingdom][microorganisms] and [human pathogenicity][mo_matching_score()] of the taxonomic outcome. If values are matched with uncertainty, a message will be shown to suggest the user to evaluate the results with [mo_uncertainties()], which returns a [data.frame] with all specifications.
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#'
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#' To increase the quality of matching, the `cleaning_regex` argument can be used to clean the input (i.e., `x`). This must be a [regular expression][base::regex] that matches parts of the input that should be removed before the input is matched against the [available microbial taxonomy][microorganisms]. It will be matched Perl-compatible and case-insensitive. The default value of `cleaning_regex` is the outcome of the helper function [mo_cleaning_regex()].
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#'
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#' There are three helper functions that can be run after using the [as.mo()] function:
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#' - Use [mo_uncertainties()] to get a [data.frame] that prints in a pretty format with all taxonomic names that were guessed. The output contains the matching score for all matches (see *Matching Score for Microorganisms* below).
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#' - Use [mo_failures()] to get a [character] [vector] with all values that could not be coerced to a valid value.
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#' - Use [mo_renamed()] to get a [data.frame] with all values that could be coerced based on old, previously accepted taxonomic names.
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#'
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#' ### Microbial Prevalence of Pathogens in Humans
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#'
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#' The coercion rules consider the prevalence of microorganisms in humans, which is available as the `prevalence` column in the [microorganisms] data set. The grouping into human pathogenic prevalence is explained in the section *Matching Score for Microorganisms* below.
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#' @inheritSection mo_matching_score Matching Score for Microorganisms
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#'
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# (source as a section here, so it can be inherited by other man pages)
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#' @section Source:
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#' 1. Berends MS *et al.* (2022). **AMR: An R Package for Working with Antimicrobial Resistance Data**. *Journal of Statistical Software*, 104(3), 1-31; \doi{10.18637/jss.v104.i03}
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#' 2. Becker K *et al.* (2014). **Coagulase-Negative Staphylococci.** *Clin Microbiol Rev.* 27(4): 870-926; \doi{10.1128/CMR.00109-13}
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#' 3. Becker K *et al.* (2019). **Implications of identifying the recently defined members of the *S. aureus* complex, *S. argenteus* and *S. schweitzeri*: A position paper of members of the ESCMID Study Group for staphylococci and Staphylococcal Diseases (ESGS).** *Clin Microbiol Infect*; \doi{10.1016/j.cmi.2019.02.028}
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#' 4. Becker K *et al.* (2020). **Emergence of coagulase-negative staphylococci.** *Expert Rev Anti Infect Ther.* 18(4):349-366; \doi{10.1080/14787210.2020.1730813}
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#' 5. Lancefield RC (1933). **A serological differentiation of human and other groups of hemolytic streptococci.** *J Exp Med.* 57(4): 571-95; \doi{10.1084/jem.57.4.571}
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#' 6. Berends MS *et al.* (2022). **Trends in Occurrence and Phenotypic Resistance of Coagulase-Negative Staphylococci (CoNS) Found in Human Blood in the Northern Netherlands between 2013 and 2019/** *Micro.rganisms* 10(9), 1801; \doi{10.3390/microorganisms10091801}
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#' 7. `r TAXONOMY_VERSION$LPSN$citation` Accessed from <`r TAXONOMY_VERSION$LPSN$url`> on `r documentation_date(TAXONOMY_VERSION$LPSN$accessed_date)`.
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#' 8. `r TAXONOMY_VERSION$GBIF$citation` Accessed from <`r TAXONOMY_VERSION$GBIF$url`> on `r documentation_date(TAXONOMY_VERSION$GBIF$accessed_date)`.
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#' 9. `r TAXONOMY_VERSION$BacDive$citation` Accessed from <`r TAXONOMY_VERSION$BacDive$url`> on `r documentation_date(TAXONOMY_VERSION$BacDive$accessed_date)`.
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#' 10. `r TAXONOMY_VERSION$SNOMED$citation` URL: <`r TAXONOMY_VERSION$SNOMED$url`>
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#' 11. Bartlett A *et al.* (2022). **A comprehensive list of bacterial pathogens infecting humans** *Microbiology* 168:001269; \doi{10.1099/mic.0.001269}
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#' @export
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#' @return A [character] [vector] with additional class [`mo`]
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#' @seealso [microorganisms] for the [data.frame] that is being used to determine ID's.
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#'
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#' The [`mo_*`][mo_property()] functions (such as [mo_genus()], [mo_gramstain()]) to get properties based on the returned code.
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#' @inheritSection AMR Reference Data Publicly Available
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#' @examples
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#' \donttest{
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#' # These examples all return "B_STPHY_AURS", the ID of S. aureus:
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#' as.mo(c(
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#' "sau", # WHONET code
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#' "stau",
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#' "STAU",
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#' "staaur",
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#' "S. aureus",
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#' "S aureus",
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#' "Sthafilokkockus aureus", # handles incorrect spelling
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#' "Staphylococcus aureus (MRSA)",
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#' "MRSA", # Methicillin Resistant S. aureus
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#' "VISA", # Vancomycin Intermediate S. aureus
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#' "VRSA", # Vancomycin Resistant S. aureus
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#' 115329001 # SNOMED CT code
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#' ))
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#'
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#' # Dyslexia is no problem - these all work:
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#' as.mo(c(
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#' "Ureaplasma urealyticum",
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#' "Ureaplasma urealyticus",
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#' "Ureaplasmium urealytica",
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#' "Ureaplazma urealitycium"
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#' ))
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#'
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#' # input will get cleaned up with the input given in the `cleaning_regex` argument,
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#' # which defaults to `mo_cleaning_regex()`:
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#' cat(mo_cleaning_regex(), "\n")
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#'
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#' as.mo("Streptococcus group A")
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#'
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#' as.mo("S. epidermidis") # will remain species: B_STPHY_EPDR
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#' as.mo("S. epidermidis", Becker = TRUE) # will not remain species: B_STPHY_CONS
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#'
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#' as.mo("S. pyogenes") # will remain species: B_STRPT_PYGN
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#' as.mo("S. pyogenes", Lancefield = TRUE) # will not remain species: B_STRPT_GRPA
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#'
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#' # All mo_* functions use as.mo() internally too (see ?mo_property):
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#' mo_genus("E. coli")
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#' mo_gramstain("ESCO")
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#' mo_is_intrinsic_resistant("ESCCOL", ab = "vanco")
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#' }
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as.mo <- function(x,
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Becker = FALSE,
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Lancefield = FALSE,
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minimum_matching_score = NULL,
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keep_synonyms = getOption("AMR_keep_synonyms", FALSE),
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reference_df = get_mo_source(),
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ignore_pattern = getOption("AMR_ignore_pattern", NULL),
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cleaning_regex = getOption("AMR_cleaning_regex", mo_cleaning_regex()),
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language = get_AMR_locale(),
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info = interactive(),
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...) {
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meet_criteria(x, allow_class = c("mo", "data.frame", "list", "character", "numeric", "integer", "factor"), allow_NA = TRUE)
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meet_criteria(Becker, allow_class = c("logical", "character"), has_length = 1)
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meet_criteria(Lancefield, allow_class = c("logical", "character"), has_length = 1)
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meet_criteria(minimum_matching_score, allow_class = c("numeric", "integer"), has_length = 1, allow_NULL = TRUE, is_positive_or_zero = TRUE, is_finite = TRUE)
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meet_criteria(keep_synonyms, allow_class = "logical", has_length = 1)
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meet_criteria(reference_df, allow_class = "data.frame", allow_NULL = TRUE)
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meet_criteria(ignore_pattern, allow_class = "character", has_length = 1, allow_NULL = TRUE)
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meet_criteria(cleaning_regex, allow_class = "character", has_length = 1, allow_NULL = TRUE)
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language <- validate_language(language)
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meet_criteria(info, allow_class = "logical", has_length = 1)
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add_MO_lookup_to_AMR_env()
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if (tryCatch(all(x %in% c(AMR_env$MO_lookup$mo, NA)), error = function(e) FALSE) &&
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isFALSE(Becker) &&
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isFALSE(Lancefield) &&
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isTRUE(keep_synonyms)) {
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# don't look into valid MO codes, just return them
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# is.mo() won't work - MO codes might change between package versions
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return(set_clean_class(x, new_class = c("mo", "character")))
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}
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# start off with replaced language-specific non-ASCII characters with ASCII characters
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x <- parse_and_convert(x)
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# replace mo codes used in older package versions
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x <- replace_old_mo_codes(x, property = "mo")
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# ignore cases that match the ignore pattern
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x <- replace_ignore_pattern(x, ignore_pattern)
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x_lower <- tolower(x)
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# WHONET: xxx = no growth
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x[x_lower %in% c("", "xxx", "na", "nan")] <- NA_character_
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out <- rep(NA_character_, length(x))
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# below we use base R's match(), known for powering '%in%', and incredibly fast!
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# From reference_df ----
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reference_df <- repair_reference_df(reference_df)
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if (!is.null(reference_df)) {
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out[x %in% reference_df[[1]]] <- reference_df[[2]][match(x[x %in% reference_df[[1]]], reference_df[[1]])]
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}
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# From MO code ----
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out[is.na(out) & toupper(x) %in% AMR_env$MO_lookup$mo] <- toupper(x[is.na(out) & toupper(x) %in% AMR_env$MO_lookup$mo])
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# From full name ----
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out[is.na(out) & x_lower %in% AMR_env$MO_lookup$fullname_lower] <- AMR_env$MO_lookup$mo[match(x_lower[is.na(out) & x_lower %in% AMR_env$MO_lookup$fullname_lower], AMR_env$MO_lookup$fullname_lower)]
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# one exception: "Fungi" matches the kingdom, but instead it should return the 'unknown' code for fungi
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out[out == "F_[KNG]_FUNGI"] <- "F_FUNGUS"
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# From known codes ----
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out[is.na(out) & toupper(x) %in% AMR::microorganisms.codes$code] <- AMR::microorganisms.codes$mo[match(toupper(x)[is.na(out) & toupper(x) %in% AMR::microorganisms.codes$code], AMR::microorganisms.codes$code)]
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# From SNOMED ----
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# based on this extremely fast gem: https://stackoverflow.com/a/11002456/4575331
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snomeds <- unlist(AMR_env$MO_lookup$snomed)
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snomeds <- snomeds[!is.na(snomeds)]
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out[is.na(out) & x %in% snomeds] <- AMR_env$MO_lookup$mo[rep(seq_along(AMR_env$MO_lookup$snomed), vapply(FUN.VALUE = double(1), AMR_env$MO_lookup$snomed, length))[match(x[is.na(out) & x %in% snomeds], snomeds)]]
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# From other familiar output ----
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# such as Salmonella groups, colloquial names, etc.
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out[is.na(out)] <- convert_colloquial_input(x[is.na(out)])
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# From previous hits in this session ----
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old <- out
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out[is.na(out) & paste(x, minimum_matching_score) %in% AMR_env$mo_previously_coerced$x] <- AMR_env$mo_previously_coerced$mo[match(paste(x, minimum_matching_score)[is.na(out) & paste(x, minimum_matching_score) %in% AMR_env$mo_previously_coerced$x], AMR_env$mo_previously_coerced$x)]
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new <- out
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if (isTRUE(info) && message_not_thrown_before("as.mo", old, new, entire_session = TRUE) && any(is.na(old) & !is.na(new), na.rm = TRUE)) {
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message_(
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"Returning previously coerced value", ifelse(sum(is.na(old) & !is.na(new)) > 1, "s", ""),
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" for ", vector_and(x[is.na(old) & !is.na(new)]), ". Run `mo_reset_session()` to reset this. This note will be shown once per session for this input."
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)
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}
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# For all other input ----
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if (any(is.na(out) & !is.na(x))) {
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# reset uncertainties
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AMR_env$mo_uncertainties <- AMR_env$mo_uncertainties[0, ]
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AMR_env$mo_failures <- NULL
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# Laboratory systems: remove (translated) entries like "no growth", "not E. coli", etc.
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x[trimws2(x) %like% translate_into_language("no .*growth", language = language)] <- NA_character_
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x[trimws2(x) %like% paste0("^(", translate_into_language("no|not", language = language), ") ")] <- NA_character_
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# groups are in our taxonomic table with a capital G
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x <- gsub(" group( |$)", " Group\\1", x, perl = TRUE)
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# run over all unique leftovers
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x_unique <- unique(x[is.na(out) & !is.na(x)])
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# set up progress bar
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progress <- progress_ticker(n = length(x_unique), n_min = 10, print = info, title = "Converting microorganism input")
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on.exit(close(progress))
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msg <- character(0)
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# run it
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x_coerced <- vapply(FUN.VALUE = character(1), x_unique, function(x_search) {
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progress$tick()
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# some required cleaning steps
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x_out <- trimws2(x_search)
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# this applies the `cleaning_regex` argument, which defaults to mo_cleaning_regex()
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x_out <- gsub(cleaning_regex, " ", x_out, ignore.case = TRUE, perl = TRUE)
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x_out <- trimws2(gsub(" +", " ", x_out, perl = TRUE))
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x_search_cleaned <- x_out
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x_out <- tolower(x_out)
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# when x_search_cleaned are only capitals (such as in codes), make them lowercase to increase matching score
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x_search_cleaned[x_search_cleaned == toupper(x_search_cleaned)] <- x_out[x_search_cleaned == toupper(x_search_cleaned)]
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# first check if cleaning led to an exact result, case-insensitive
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if (x_out %in% AMR_env$MO_lookup$fullname_lower) {
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return(as.character(AMR_env$MO_lookup$mo[match(x_out, AMR_env$MO_lookup$fullname_lower)]))
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}
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# input must not be too short
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if (nchar(x_out) < 3) {
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return("UNKNOWN")
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}
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# take out the parts, split by space
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x_parts <- strsplit(gsub("-", " ", x_out, fixed = TRUE), " ", fixed = TRUE)[[1]]
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# do a pre-match on first character (and if it contains a space, first chars of first two terms)
|
|
if (length(x_parts) %in% c(2, 3)) {
|
|
# for genus + species + subspecies
|
|
if (nchar(gsub("[^a-z]", "", x_parts[1], perl = TRUE)) <= 3) {
|
|
filtr <- which(AMR_env$MO_lookup$full_first == substr(x_parts[1], 1, 1) &
|
|
(AMR_env$MO_lookup$species_first == substr(x_parts[2], 1, 1) |
|
|
AMR_env$MO_lookup$subspecies_first == substr(x_parts[2], 1, 1) |
|
|
AMR_env$MO_lookup$subspecies_first == substr(x_parts[3], 1, 1)))
|
|
} else {
|
|
filtr <- which(AMR_env$MO_lookup$full_first == substr(x_parts[1], 1, 1) |
|
|
AMR_env$MO_lookup$species_first == substr(x_parts[2], 1, 1) |
|
|
AMR_env$MO_lookup$subspecies_first == substr(x_parts[2], 1, 1) |
|
|
AMR_env$MO_lookup$subspecies_first == substr(x_parts[3], 1, 1))
|
|
}
|
|
} else if (length(x_parts) > 3) {
|
|
first_chars <- paste0("(^| )[", paste(substr(x_parts, 1, 1), collapse = ""), "]")
|
|
filtr <- which(AMR_env$MO_lookup$full_first %like_case% first_chars)
|
|
} else if (nchar(x_out) == 3) {
|
|
# no space and 3 characters - probably a code such as SAU or ECO
|
|
msg <<- c(msg, paste0("Input \"", x_search, "\" was assumed to be a microorganism code - tried to match on \"", totitle(substr(x_out, 1, 1)), AMR_env$dots, " ", substr(x_out, 2, 3), AMR_env$dots, "\""))
|
|
filtr <- which(AMR_env$MO_lookup$fullname_lower %like_case% paste0("(^| )", substr(x_out, 1, 1), ".* ", substr(x_out, 2, 3)))
|
|
} else if (nchar(x_out) == 4) {
|
|
# no space and 4 characters - probably a code such as STAU or ESCO
|
|
msg <<- c(msg, paste0("Input \"", x_search, "\" was assumed to be a microorganism code - tried to match on \"", totitle(substr(x_out, 1, 2)), AMR_env$dots, " ", substr(x_out, 3, 4), AMR_env$dots, "\""))
|
|
filtr <- which(AMR_env$MO_lookup$fullname_lower %like_case% paste0("(^| )", substr(x_out, 1, 2), ".* ", substr(x_out, 3, 4)))
|
|
} else if (nchar(x_out) <= 6) {
|
|
# no space and 5-6 characters - probably a code such as STAAUR or ESCCOL
|
|
first_part <- paste0(substr(x_out, 1, 2), "[a-z]*", substr(x_out, 3, 3))
|
|
second_part <- substr(x_out, 4, nchar(x_out))
|
|
msg <<- c(msg, paste0("Input \"", x_search, "\" was assumed to be a microorganism code - tried to match on \"", gsub("[a-z]*", AMR_env$dots, totitle(first_part), fixed = TRUE), " ", second_part, AMR_env$dots, "\""))
|
|
filtr <- which(AMR_env$MO_lookup$fullname_lower %like_case% paste0("(^| )", first_part, ".* ", second_part))
|
|
} else {
|
|
# for genus or species or subspecies
|
|
filtr <- which(AMR_env$MO_lookup$full_first == substr(x_parts, 1, 1) |
|
|
AMR_env$MO_lookup$species_first == substr(x_parts, 1, 1) |
|
|
AMR_env$MO_lookup$subspecies_first == substr(x_parts, 1, 1))
|
|
}
|
|
if (length(filtr) == 0) {
|
|
mo_to_search <- AMR_env$MO_lookup$fullname
|
|
} else {
|
|
mo_to_search <- AMR_env$MO_lookup$fullname[filtr]
|
|
}
|
|
|
|
AMR_env$mo_to_search <- mo_to_search
|
|
# determine the matching score on the original search value
|
|
m <- mo_matching_score(x = x_search_cleaned, n = mo_to_search)
|
|
if (is.null(minimum_matching_score)) {
|
|
minimum_matching_score_current <- min(0.6, min(10, nchar(x_search_cleaned)) * 0.08)
|
|
# correct back for prevalence
|
|
minimum_matching_score_current <- minimum_matching_score_current / AMR_env$MO_lookup$prevalence[match(mo_to_search, AMR_env$MO_lookup$fullname)]
|
|
# correct back for kingdom
|
|
minimum_matching_score_current <- minimum_matching_score_current / AMR_env$MO_lookup$kingdom_index[match(mo_to_search, AMR_env$MO_lookup$fullname)]
|
|
minimum_matching_score_current <- pmax(minimum_matching_score_current, m)
|
|
if (length(x_parts) > 1 && all(m <= 0.55, na.rm = TRUE)) {
|
|
# if the highest score is 0.5, we have nothing serious - 0.5 is the lowest for pathogenic group 1
|
|
# make everything NA so the results will get removed below
|
|
# (we added length(x_parts) > 1 to exclude microbial codes from this rule, such as "STAU")
|
|
m[seq_len(length(m))] <- NA_real_
|
|
}
|
|
} else {
|
|
# minimum_matching_score was set, so remove everything below it
|
|
m[m < minimum_matching_score] <- NA_real_
|
|
minimum_matching_score_current <- minimum_matching_score
|
|
}
|
|
|
|
top_hits <- mo_to_search[order(m, decreasing = TRUE, na.last = NA)] # na.last = NA will remove the NAs
|
|
if (length(top_hits) == 0) {
|
|
warning_("No hits found for \"", x_search, "\" with minimum_matching_score = ", ifelse(is.null(minimum_matching_score), paste0("NULL (=", round(min(minimum_matching_score_current, na.rm = TRUE), 3), ")"), minimum_matching_score), ". Try setting this value lower or even to 0.", call = FALSE)
|
|
result_mo <- NA_character_
|
|
} else {
|
|
result_mo <- AMR_env$MO_lookup$mo[match(top_hits[1], AMR_env$MO_lookup$fullname)]
|
|
AMR_env$mo_uncertainties <- rbind_AMR(
|
|
AMR_env$mo_uncertainties,
|
|
data.frame(
|
|
original_input = x_search,
|
|
input = x_search_cleaned,
|
|
fullname = top_hits[1],
|
|
mo = result_mo,
|
|
candidates = ifelse(length(top_hits) > 1, paste(top_hits[2:min(99, length(top_hits))], collapse = ", "), ""),
|
|
minimum_matching_score = ifelse(is.null(minimum_matching_score), "NULL", minimum_matching_score),
|
|
keep_synonyms = keep_synonyms,
|
|
stringsAsFactors = FALSE
|
|
)
|
|
)
|
|
# save to package env to save time for next time
|
|
AMR_env$mo_previously_coerced <- unique(rbind_AMR(
|
|
AMR_env$mo_previously_coerced,
|
|
data.frame(
|
|
x = paste(x_search, minimum_matching_score),
|
|
mo = result_mo,
|
|
stringsAsFactors = FALSE
|
|
)
|
|
))
|
|
}
|
|
# the actual result:
|
|
as.character(result_mo)
|
|
})
|
|
|
|
# remove progress bar from console
|
|
close(progress)
|
|
# expand from unique again
|
|
out[is.na(out)] <- x_coerced[match(x[is.na(out)], x_unique)]
|
|
|
|
# Throw note about uncertainties ----
|
|
if (isTRUE(info) && NROW(AMR_env$mo_uncertainties) > 0) {
|
|
if (message_not_thrown_before("as.mo", "uncertainties", AMR_env$mo_uncertainties$original_input)) {
|
|
plural <- c("", "this")
|
|
if (length(AMR_env$mo_uncertainties$original_input) > 1) {
|
|
plural <- c("s", "these uncertainties")
|
|
}
|
|
if (length(AMR_env$mo_uncertainties$original_input) <= 3) {
|
|
examples <- vector_and(
|
|
paste0(
|
|
'"', AMR_env$mo_uncertainties$original_input,
|
|
'" (assumed ', italicise(AMR_env$mo_uncertainties$fullname), ")"
|
|
),
|
|
quotes = FALSE
|
|
)
|
|
} else {
|
|
examples <- paste0(nr2char(length(AMR_env$mo_uncertainties$original_input)), " microorganism", plural[1])
|
|
}
|
|
msg <- c(msg, paste0(
|
|
"Microorganism translation was uncertain for ", examples,
|
|
". Run `mo_uncertainties()` to review ", plural[2], ", or use `add_custom_microorganisms()` to add custom entries."
|
|
))
|
|
|
|
for (m in msg) {
|
|
message_(m)
|
|
}
|
|
}
|
|
}
|
|
} # end of loop over all yet unknowns
|
|
|
|
# Keep or replace synonyms ----
|
|
lpsn_matches <- AMR_env$MO_lookup$lpsn_renamed_to[match(out, AMR_env$MO_lookup$mo)]
|
|
lpsn_matches[!lpsn_matches %in% AMR_env$MO_lookup$lpsn] <- NA
|
|
# GBIF only for non-bacteria, since we use LPSN as primary source for bacteria
|
|
# (an example is Strep anginosus, renamed according to GBIF, not according to LPSN)
|
|
gbif_matches <- AMR_env$MO_lookup$gbif_renamed_to[AMR_env$MO_lookup$kingdom != "Bacteria"][match(out, AMR_env$MO_lookup$mo[AMR_env$MO_lookup$kingdom != "Bacteria"])]
|
|
gbif_matches[!gbif_matches %in% AMR_env$MO_lookup$gbif] <- NA
|
|
AMR_env$mo_renamed <- list(
|
|
old = out[!is.na(gbif_matches) | !is.na(lpsn_matches)],
|
|
gbif_matches = gbif_matches[!is.na(gbif_matches) | !is.na(lpsn_matches)],
|
|
lpsn_matches = lpsn_matches[!is.na(gbif_matches) | !is.na(lpsn_matches)]
|
|
)
|
|
if (isFALSE(keep_synonyms)) {
|
|
out[which(!is.na(gbif_matches))] <- AMR_env$MO_lookup$mo[match(gbif_matches[which(!is.na(gbif_matches))], AMR_env$MO_lookup$gbif)]
|
|
out[which(!is.na(lpsn_matches))] <- AMR_env$MO_lookup$mo[match(lpsn_matches[which(!is.na(lpsn_matches))], AMR_env$MO_lookup$lpsn)]
|
|
if (isTRUE(info) && length(AMR_env$mo_renamed$old) > 0) {
|
|
print(mo_renamed(), extra_txt = " (use `keep_synonyms = TRUE` to leave uncorrected)")
|
|
}
|
|
} else if (is.null(getOption("AMR_keep_synonyms")) && length(AMR_env$mo_renamed$old) > 0 && message_not_thrown_before("as.mo", "keep_synonyms_warning", entire_session = TRUE)) {
|
|
# keep synonyms is TRUE, so check if any do have synonyms
|
|
warning_("Function `as.mo()` returned ", nr2char(length(unique(AMR_env$mo_renamed$old))), " old taxonomic name", ifelse(length(unique(AMR_env$mo_renamed$old)) > 1, "s", ""), ". Use `as.mo(..., keep_synonyms = FALSE)` to clean the input to currently accepted taxonomic names, or set the R option `AMR_keep_synonyms` to `FALSE`. This warning will be shown once per session.", call = FALSE)
|
|
}
|
|
|
|
# Apply Becker ----
|
|
if (isTRUE(Becker) || Becker == "all") {
|
|
# warn when species found that are not in:
|
|
# - Becker et al. 2014, PMID 25278577
|
|
# - Becker et al. 2019, PMID 30872103
|
|
# - Becker et al. 2020, PMID 32056452
|
|
|
|
# comment below code if all staphylococcal species are categorised as CoNS/CoPS
|
|
post_Becker <- paste(
|
|
"Staphylococcus",
|
|
c("caledonicus", "canis", "durrellii", "lloydii", "ratti", "roterodami", "singaporensis", "taiwanensis")
|
|
)
|
|
if (any(out %in% AMR_env$MO_lookup$mo[match(post_Becker, AMR_env$MO_lookup$fullname)])) {
|
|
if (message_not_thrown_before("as.mo", "becker")) {
|
|
warning_("in `as.mo()`: Becker ", font_italic("et al."), " (2014, 2019, 2020) does not contain these species named after their publication: ",
|
|
vector_and(font_italic(gsub("Staphylococcus", "S.", post_Becker, fixed = TRUE), collapse = NULL), quotes = FALSE),
|
|
". Categorisation to CoNS/CoPS was taken from the original scientific publication(s).",
|
|
immediate = TRUE, call = FALSE
|
|
)
|
|
}
|
|
}
|
|
|
|
# 'MO_CONS' and 'MO_COPS' are 'mo' vectors created in R/_pre_commit_checks.R
|
|
out[out %in% MO_CONS] <- "B_STPHY_CONS"
|
|
out[out %in% MO_COPS] <- "B_STPHY_COPS"
|
|
if (Becker == "all") {
|
|
out[out == "B_STPHY_AURS"] <- "B_STPHY_COPS"
|
|
}
|
|
}
|
|
|
|
# Apply Lancefield ----
|
|
if (isTRUE(Lancefield) || Lancefield == "all") {
|
|
# (using `%like_case%` to also match subspecies)
|
|
|
|
# group A - S. pyogenes
|
|
out[out %like_case% "^B_STRPT_PYGN(_|$)"] <- "B_STRPT_GRPA"
|
|
# group B - S. agalactiae
|
|
out[out %like_case% "^B_STRPT_AGLC(_|$)"] <- "B_STRPT_GRPB"
|
|
# group C - all subspecies within S. dysgalactiae and S. equi (such as S. equi zooepidemicus)
|
|
out[out %like_case% "^B_STRPT_(DYSG|EQUI)(_|$)"] <- "B_STRPT_GRPC"
|
|
if (Lancefield == "all") {
|
|
# group D - all enterococci
|
|
out[out %like_case% "^B_ENTRC(_|$)"] <- "B_STRPT_GRPD"
|
|
}
|
|
# group F - Milleri group == S. anginosus group, which incl. S. anginosus, S. constellatus, S. intermedius
|
|
out[out %like_case% "^B_STRPT_(ANGN|CNST|INTR)(_|$)"] <- "B_STRPT_GRPF"
|
|
# group G - S. dysgalactiae and S. canis (though dysgalactiae is also group C and will be matched there)
|
|
out[out %like_case% "^B_STRPT_(DYSG|CANS)(_|$)"] <- "B_STRPT_GRPG"
|
|
# group H - S. sanguinis
|
|
out[out %like_case% "^B_STRPT_SNGN(_|$)"] <- "B_STRPT_GRPH"
|
|
# group K - S. salivarius, incl. S. salivarius salivarius and S. salivarius thermophilus
|
|
out[out %like_case% "^B_STRPT_SLVR(_|$)"] <- "B_STRPT_GRPK"
|
|
# group L - only S. dysgalactiae which is also group C & G, so ignore it here
|
|
}
|
|
|
|
# All unknowns ----
|
|
out[is.na(out) & !is.na(x)] <- "UNKNOWN"
|
|
AMR_env$mo_failures <- unique(x[out == "UNKNOWN" & !toupper(x) %in% c("UNKNOWN", "CON", "UNK") & !x %like_case% "^[(]unknown [a-z]+[)]$" & !is.na(x)])
|
|
if (length(AMR_env$mo_failures) > 0) {
|
|
warning_("The following input could not be coerced and was returned as \"UNKNOWN\": ", vector_and(AMR_env$mo_failures, quotes = TRUE), ".\nYou can retrieve this list with `mo_failures()`.", call = FALSE)
|
|
}
|
|
|
|
# Return class ----
|
|
set_clean_class(out,
|
|
new_class = c("mo", "character")
|
|
)
|
|
}
|
|
|
|
# OTHER DOCUMENTED FUNCTIONS ----------------------------------------------
|
|
|
|
#' @rdname as.mo
|
|
#' @export
|
|
is.mo <- function(x) {
|
|
inherits(x, "mo")
|
|
}
|
|
|
|
#' @rdname as.mo
|
|
#' @export
|
|
mo_uncertainties <- function() {
|
|
set_clean_class(AMR_env$mo_uncertainties, new_class = c("mo_uncertainties", "data.frame"))
|
|
}
|
|
|
|
#' @rdname as.mo
|
|
#' @export
|
|
mo_renamed <- function() {
|
|
add_MO_lookup_to_AMR_env()
|
|
x <- AMR_env$mo_renamed
|
|
|
|
x$new <- synonym_mo_to_accepted_mo(x$old)
|
|
mo_old <- AMR_env$MO_lookup$fullname[match(x$old, AMR_env$MO_lookup$mo)]
|
|
mo_new <- AMR_env$MO_lookup$fullname[match(x$new, AMR_env$MO_lookup$mo)]
|
|
ref_old <- AMR_env$MO_lookup$ref[match(x$old, AMR_env$MO_lookup$mo)]
|
|
ref_new <- AMR_env$MO_lookup$ref[match(x$new, AMR_env$MO_lookup$mo)]
|
|
|
|
df_renamed <- data.frame(
|
|
old = mo_old,
|
|
new = mo_new,
|
|
ref_old = ref_old,
|
|
ref_new = ref_new,
|
|
stringsAsFactors = FALSE
|
|
)
|
|
df_renamed <- unique(df_renamed)
|
|
df_renamed <- df_renamed[order(df_renamed$old), , drop = FALSE]
|
|
set_clean_class(df_renamed, new_class = c("mo_renamed", "data.frame"))
|
|
}
|
|
|
|
#' @rdname as.mo
|
|
#' @export
|
|
mo_failures <- function() {
|
|
AMR_env$mo_failures
|
|
}
|
|
|
|
#' @rdname as.mo
|
|
#' @export
|
|
mo_reset_session <- function() {
|
|
if (NROW(AMR_env$mo_previously_coerced) > 0) {
|
|
message_("Reset ", nr2char(NROW(AMR_env$mo_previously_coerced)), " previously matched input value", ifelse(NROW(AMR_env$mo_previously_coerced) > 1, "s", ""), ".")
|
|
AMR_env$mo_previously_coerced <- AMR_env$mo_previously_coerced[0, , drop = FALSE]
|
|
AMR_env$mo_uncertainties <- AMR_env$mo_uncertainties[0, , drop = FALSE]
|
|
} else {
|
|
message_("No previously matched input values to reset.")
|
|
}
|
|
}
|
|
|
|
#' @rdname as.mo
|
|
#' @export
|
|
mo_cleaning_regex <- function() {
|
|
parts_to_remove <- c("e?spp([^a-z]+|$)", "e?ssp([^a-z]+|$)", "e?ss([^a-z]+|$)", "e?sp([^a-z]+|$)", "e?subsp", "sube?species", "e?species",
|
|
"biovar[a-z]*", "biotype", "serovar[a-z]*", "var([^a-z]+|$)", "serogr.?up[a-z]*",
|
|
"titer", "dummy", "Ig[ADEGM]")
|
|
paste0(
|
|
"(",
|
|
"[^A-Za-z- \\(\\)\\[\\]{}]+",
|
|
"|",
|
|
"([({]|\\[).+([})]|\\])",
|
|
"|(^| )(",
|
|
paste0(parts_to_remove[order(1 - nchar(parts_to_remove))], collapse = "|"),
|
|
"))")
|
|
}
|
|
|
|
# UNDOCUMENTED METHODS ----------------------------------------------------
|
|
|
|
# will be exported using s3_register() in R/zzz.R
|
|
pillar_shaft.mo <- function(x, ...) {
|
|
add_MO_lookup_to_AMR_env()
|
|
out <- trimws(format(x))
|
|
# grey out the kingdom (part until first "_")
|
|
out[!is.na(x)] <- gsub("^([A-Z]+_)(.*)", paste0(font_subtle("\\1"), "\\2"), out[!is.na(x)], perl = TRUE)
|
|
# and grey out every _
|
|
out[!is.na(x)] <- gsub("_", font_subtle("_"), out[!is.na(x)])
|
|
|
|
# markup NA and UNKNOWN
|
|
out[is.na(x)] <- font_na(" NA")
|
|
out[x == "UNKNOWN"] <- font_na(" UNKNOWN")
|
|
|
|
# markup manual codes
|
|
out[x %in% AMR_env$MO_lookup$mo & !x %in% AMR::microorganisms$mo] <- font_blue(out[x %in% AMR_env$MO_lookup$mo & !x %in% AMR::microorganisms$mo], collapse = NULL)
|
|
|
|
df <- tryCatch(get_current_data(arg_name = "x", call = 0),
|
|
error = function(e) NULL
|
|
)
|
|
if (!is.null(df)) {
|
|
mo_cols <- vapply(FUN.VALUE = logical(1), df, is.mo)
|
|
} else {
|
|
mo_cols <- NULL
|
|
}
|
|
|
|
all_mos <- c(AMR_env$MO_lookup$mo, NA)
|
|
if (!all(x %in% all_mos) ||
|
|
(!is.null(df) && !all(unlist(df[, which(mo_cols), drop = FALSE]) %in% all_mos))) {
|
|
# markup old mo codes
|
|
out[!x %in% all_mos] <- font_italic(
|
|
font_na(x[!x %in% all_mos],
|
|
collapse = NULL
|
|
),
|
|
collapse = NULL
|
|
)
|
|
# throw a warning with the affected column name(s)
|
|
if (!is.null(mo_cols)) {
|
|
col <- paste0("Column ", vector_or(colnames(df)[mo_cols], quotes = TRUE, sort = FALSE))
|
|
} else {
|
|
col <- "The data"
|
|
}
|
|
warning_(
|
|
col, " contains old MO codes (from a previous AMR package version). ",
|
|
"Please update your MO codes with `as.mo()`.",
|
|
call = FALSE
|
|
)
|
|
}
|
|
|
|
# add the names to the bugs as mouse-over!
|
|
if (tryCatch(isTRUE(getExportedValue("ansi_has_hyperlink_support", ns = asNamespace("cli"))()), error = function(e) FALSE)) {
|
|
out[!x %in% c("UNKNOWN", NA)] <- font_url(url = paste0(x[!x %in% c("UNKNOWN", NA)], ": ",
|
|
mo_name(x[!x %in% c("UNKNOWN", NA)], keep_synonyms = TRUE)),
|
|
txt = out[!x %in% c("UNKNOWN", NA)])
|
|
}
|
|
|
|
# make it always fit exactly
|
|
max_char <- max(nchar(x))
|
|
if (is.na(max_char)) {
|
|
max_char <- 12
|
|
}
|
|
create_pillar_column(out,
|
|
align = "left",
|
|
width = max_char + ifelse(any(x %in% c(NA, "UNKNOWN")), 2, 0)
|
|
)
|
|
}
|
|
|
|
# will be exported using s3_register() in R/zzz.R
|
|
type_sum.mo <- function(x, ...) {
|
|
"mo"
|
|
}
|
|
|
|
# will be exported using s3_register() in R/zzz.R
|
|
freq.mo <- function(x, ...) {
|
|
x_noNA <- as.mo(x[!is.na(x)]) # as.mo() to get the newest mo codes
|
|
grams <- mo_gramstain(x_noNA, language = NULL)
|
|
digits <- list(...)$digits
|
|
if (is.null(digits)) {
|
|
digits <- 2
|
|
}
|
|
cleaner::freq.default(
|
|
x = x,
|
|
...,
|
|
.add_header = list(
|
|
`Gram-negative` = paste0(
|
|
format(sum(grams == "Gram-negative", na.rm = TRUE),
|
|
big.mark = " ",
|
|
decimal.mark = "."
|
|
),
|
|
" (", percentage(sum(grams == "Gram-negative", na.rm = TRUE) / length(grams),
|
|
digits = digits
|
|
),
|
|
")"
|
|
),
|
|
`Gram-positive` = paste0(
|
|
format(sum(grams == "Gram-positive", na.rm = TRUE),
|
|
big.mark = " ",
|
|
decimal.mark = "."
|
|
),
|
|
" (", percentage(sum(grams == "Gram-positive", na.rm = TRUE) / length(grams),
|
|
digits = digits
|
|
),
|
|
")"
|
|
),
|
|
`Nr. of genera` = pm_n_distinct(mo_genus(x_noNA, language = NULL)),
|
|
`Nr. of species` = pm_n_distinct(paste(
|
|
mo_genus(x_noNA, language = NULL),
|
|
mo_species(x_noNA, language = NULL)
|
|
))
|
|
)
|
|
)
|
|
}
|
|
|
|
# will be exported using s3_register() in R/zzz.R
|
|
get_skimmers.mo <- function(column) {
|
|
skimr::sfl(
|
|
skim_type = "mo",
|
|
unique_total = ~ length(unique(stats::na.omit(.))),
|
|
gram_negative = ~ sum(mo_is_gram_negative(.), na.rm = TRUE),
|
|
gram_positive = ~ sum(mo_is_gram_positive(.), na.rm = TRUE),
|
|
top_genus = ~ names(sort(-table(mo_genus(stats::na.omit(.), language = NULL))))[1L],
|
|
top_species = ~ names(sort(-table(mo_name(stats::na.omit(.), language = NULL))))[1L]
|
|
)
|
|
}
|
|
|
|
#' @method print mo
|
|
#' @export
|
|
#' @noRd
|
|
print.mo <- function(x, print.shortnames = FALSE, ...) {
|
|
add_MO_lookup_to_AMR_env()
|
|
cat("Class 'mo'\n")
|
|
x_names <- names(x)
|
|
if (is.null(x_names) & print.shortnames == TRUE) {
|
|
x_names <- tryCatch(mo_shortname(x, ...), error = function(e) NULL)
|
|
}
|
|
x <- as.character(x)
|
|
names(x) <- x_names
|
|
if (!all(x %in% c(AMR_env$MO_lookup$mo, NA))) {
|
|
warning_(
|
|
"Some MO codes are from a previous AMR package version. ",
|
|
"Please update the MO codes with `as.mo()`.",
|
|
call = FALSE
|
|
)
|
|
}
|
|
print.default(x, quote = FALSE)
|
|
}
|
|
|
|
#' @method summary mo
|
|
#' @export
|
|
#' @noRd
|
|
summary.mo <- function(object, ...) {
|
|
# unique and top 1-3
|
|
x <- object
|
|
top_3 <- names(sort(-table(x[!is.na(x)])))[1:3]
|
|
out <- c(
|
|
"Class" = "mo",
|
|
"<NA>" = length(x[is.na(x)]),
|
|
"Unique" = length(unique(x[!is.na(x)])),
|
|
"#1" = top_3[1],
|
|
"#2" = top_3[2],
|
|
"#3" = top_3[3]
|
|
)
|
|
class(out) <- c("summaryDefault", "table")
|
|
out
|
|
}
|
|
|
|
#' @method as.data.frame mo
|
|
#' @export
|
|
#' @noRd
|
|
as.data.frame.mo <- function(x, ...) {
|
|
add_MO_lookup_to_AMR_env()
|
|
if (!all(x %in% c(AMR_env$MO_lookup$mo, NA))) {
|
|
warning_(
|
|
"The data contains old MO codes (from a previous AMR package version). ",
|
|
"Please update your MO codes with `as.mo()`."
|
|
)
|
|
}
|
|
nm <- deparse1(substitute(x))
|
|
if (!"nm" %in% names(list(...))) {
|
|
as.data.frame.vector(x, ..., nm = nm)
|
|
} else {
|
|
as.data.frame.vector(x, ...)
|
|
}
|
|
}
|
|
|
|
#' @method [ mo
|
|
#' @export
|
|
#' @noRd
|
|
"[.mo" <- function(x, ...) {
|
|
y <- NextMethod()
|
|
attributes(y) <- attributes(x)
|
|
y
|
|
}
|
|
#' @method [[ mo
|
|
#' @export
|
|
#' @noRd
|
|
"[[.mo" <- function(x, ...) {
|
|
y <- NextMethod()
|
|
attributes(y) <- attributes(x)
|
|
y
|
|
}
|
|
#' @method [<- mo
|
|
#' @export
|
|
#' @noRd
|
|
"[<-.mo" <- function(i, j, ..., value) {
|
|
y <- NextMethod()
|
|
attributes(y) <- attributes(i)
|
|
# must only contain valid MOs
|
|
add_MO_lookup_to_AMR_env()
|
|
return_after_integrity_check(y, "microorganism code", as.character(AMR_env$MO_lookup$mo))
|
|
}
|
|
#' @method [[<- mo
|
|
#' @export
|
|
#' @noRd
|
|
"[[<-.mo" <- function(i, j, ..., value) {
|
|
y <- NextMethod()
|
|
attributes(y) <- attributes(i)
|
|
# must only contain valid MOs
|
|
add_MO_lookup_to_AMR_env()
|
|
return_after_integrity_check(y, "microorganism code", as.character(AMR_env$MO_lookup$mo))
|
|
}
|
|
#' @method c mo
|
|
#' @export
|
|
#' @noRd
|
|
c.mo <- function(...) {
|
|
x <- list(...)[[1L]]
|
|
y <- NextMethod()
|
|
attributes(y) <- attributes(x)
|
|
add_MO_lookup_to_AMR_env()
|
|
return_after_integrity_check(y, "microorganism code", as.character(AMR_env$MO_lookup$mo))
|
|
}
|
|
|
|
#' @method unique mo
|
|
#' @export
|
|
#' @noRd
|
|
unique.mo <- function(x, incomparables = FALSE, ...) {
|
|
y <- NextMethod()
|
|
attributes(y) <- attributes(x)
|
|
y
|
|
}
|
|
|
|
#' @method rep mo
|
|
#' @export
|
|
#' @noRd
|
|
rep.mo <- function(x, ...) {
|
|
y <- NextMethod()
|
|
attributes(y) <- attributes(x)
|
|
y
|
|
}
|
|
|
|
#' @method print mo_uncertainties
|
|
#' @export
|
|
#' @noRd
|
|
print.mo_uncertainties <- function(x, n = 10, ...) {
|
|
more_than_50 <- FALSE
|
|
if (NROW(x) == 0) {
|
|
cat(word_wrap("No uncertainties to show. Only uncertainties of the last call to `as.mo()` or any `mo_*()` function are stored.\n\n", add_fn = font_blue))
|
|
return(invisible(NULL))
|
|
} else if (NROW(x) > 50) {
|
|
more_than_50 <- TRUE
|
|
x <- x[1:50, , drop = FALSE]
|
|
}
|
|
|
|
cat(word_wrap("Matching scores are based on the resemblance between the input and the full taxonomic name, and the pathogenicity in humans. See `?mo_matching_score`.\n\n", add_fn = font_blue))
|
|
|
|
add_MO_lookup_to_AMR_env()
|
|
|
|
col_red <- function(x) font_rose_bg(x, collapse = NULL)
|
|
col_orange <- function(x) font_orange_bg(x, collapse = NULL)
|
|
col_yellow <- function(x) font_yellow_bg(x, collapse = NULL)
|
|
col_green <- function(x) font_green_bg(x, collapse = NULL)
|
|
|
|
if (has_colour()) {
|
|
cat(word_wrap("Colour keys: ",
|
|
col_red(" 0.000-0.549 "),
|
|
col_orange(" 0.550-0.649 "),
|
|
col_yellow(" 0.650-0.749 "),
|
|
col_green(" 0.750-1.000"),
|
|
add_fn = font_blue
|
|
), font_green_bg(" "), "\n", sep = "")
|
|
}
|
|
|
|
score_set_colour <- function(text, scores) {
|
|
# set colours to scores
|
|
text[scores >= 0.75] <- col_green(text[scores >= 0.75])
|
|
text[scores >= 0.65 & scores < 0.75] <- col_yellow(text[scores >= 0.65 & scores < 0.75])
|
|
text[scores >= 0.55 & scores < 0.65] <- col_orange(text[scores >= 0.55 & scores < 0.65])
|
|
text[scores < 0.55] <- col_red(text[scores < 0.55])
|
|
text
|
|
}
|
|
|
|
txt <- ""
|
|
any_maxed_out <- FALSE
|
|
for (i in seq_len(nrow(x))) {
|
|
if (x[i, ]$candidates != "") {
|
|
candidates <- unlist(strsplit(x[i, ]$candidates, ", ", fixed = TRUE))
|
|
if (length(candidates) > n) {
|
|
any_maxed_out <- TRUE
|
|
candidates <- candidates[seq_len(n)]
|
|
}
|
|
scores <- mo_matching_score(x = x[i, ]$input, n = candidates)
|
|
n_candidates <- length(candidates)
|
|
|
|
candidates_formatted <- italicise(candidates)
|
|
scores_formatted <- trimws(formatC(round(scores, 3), format = "f", digits = 3))
|
|
scores_formatted <- score_set_colour(scores_formatted, scores)
|
|
|
|
# sort on descending scores
|
|
candidates_formatted <- candidates_formatted[order(1 - scores)]
|
|
scores_formatted <- scores_formatted[order(1 - scores)]
|
|
|
|
candidates <- word_wrap(
|
|
paste0(
|
|
"Also matched: ",
|
|
vector_and(
|
|
paste0(
|
|
candidates_formatted,
|
|
font_blue(paste0(" (", scores_formatted, ")"), collapse = NULL)
|
|
),
|
|
quotes = FALSE, sort = FALSE
|
|
)
|
|
),
|
|
extra_indent = nchar("Also matched: "),
|
|
width = 0.9 * getOption("width", 100)
|
|
)
|
|
} else {
|
|
candidates <- ""
|
|
}
|
|
|
|
score <- mo_matching_score(
|
|
x = x[i, ]$input,
|
|
n = x[i, ]$fullname
|
|
)
|
|
score_formatted <- trimws(formatC(round(score, 3), format = "f", digits = 3))
|
|
txt <- paste(txt,
|
|
paste0(
|
|
paste0(
|
|
"", strrep(font_grey("-"), times = getOption("width", 100)), "\n",
|
|
'"', x[i, ]$original_input, '"',
|
|
" -> ",
|
|
paste0(
|
|
font_bold(italicise(x[i, ]$fullname)),
|
|
" (", x[i, ]$mo, ", ", score_set_colour(score_formatted, score), ")"
|
|
)
|
|
),
|
|
collapse = "\n"
|
|
),
|
|
# Add note if result was coerced to accepted taxonomic name
|
|
ifelse(x[i, ]$keep_synonyms == FALSE & x[i, ]$mo %in% AMR_env$MO_lookup$mo[which(AMR_env$MO_lookup$status == "synonym")],
|
|
paste0(
|
|
strrep(" ", nchar(x[i, ]$original_input) + 6),
|
|
font_red(paste0("This old taxonomic name was converted to ", font_italic(AMR_env$MO_lookup$fullname[match(synonym_mo_to_accepted_mo(x[i, ]$mo), AMR_env$MO_lookup$mo)], collapse = NULL), " (", synonym_mo_to_accepted_mo(x[i, ]$mo), ")."), collapse = NULL)
|
|
),
|
|
""
|
|
),
|
|
candidates,
|
|
sep = "\n"
|
|
)
|
|
txt <- gsub("[\n]+", "\n", txt)
|
|
# remove first and last break
|
|
txt <- gsub("(^[\n]|[\n]$)", "", txt)
|
|
txt <- paste0("\n", txt, "\n")
|
|
}
|
|
|
|
cat(txt)
|
|
if (isTRUE(any_maxed_out)) {
|
|
cat(font_blue(word_wrap("\nOnly the first ", n, " other matches of each record are shown. Run `print(mo_uncertainties(), n = ...)` to view more entries, or save `mo_uncertainties()` to an object.")))
|
|
}
|
|
if (isTRUE(more_than_50)) {
|
|
cat(font_blue(word_wrap("\nOnly the first 50 uncertainties are shown. Run `View(mo_uncertainties())` to view all entries, or save `mo_uncertainties()` to an object.")))
|
|
}
|
|
}
|
|
|
|
#' @method print mo_renamed
|
|
#' @export
|
|
#' @noRd
|
|
print.mo_renamed <- function(x, extra_txt = "", n = 25, ...) {
|
|
if (NROW(x) == 0) {
|
|
cat(word_wrap("No renamed taxonomy to show. Only renamed taxonomy of the last call of `as.mo()` or any `mo_*()` function are stored.\n", add_fn = font_blue))
|
|
return(invisible(NULL))
|
|
}
|
|
|
|
x$ref_old[!is.na(x$ref_old)] <- paste0(" (", gsub("et al.", font_italic("et al."), x$ref_old[!is.na(x$ref_old)], fixed = TRUE), ")")
|
|
x$ref_new[!is.na(x$ref_new)] <- paste0(" (", gsub("et al.", font_italic("et al."), x$ref_new[!is.na(x$ref_new)], fixed = TRUE), ")")
|
|
x$ref_old[is.na(x$ref_old)] <- " (author unknown)"
|
|
x$ref_new[is.na(x$ref_new)] <- " (author unknown)"
|
|
|
|
rows <- seq_len(min(NROW(x), n))
|
|
|
|
message_(
|
|
"The following microorganism", ifelse(NROW(x) > 1, "s were", " was"), " taxonomically renamed", extra_txt, ":\n",
|
|
paste0(" ", AMR_env$bullet_icon, " ", font_italic(x$old[rows], collapse = NULL), x$ref_old[rows],
|
|
" -> ", font_italic(x$new[rows], collapse = NULL), x$ref_new[rows],
|
|
collapse = "\n"
|
|
),
|
|
ifelse(NROW(x) > n, paste0("\n\nOnly the first ", n, " (out of ", NROW(x), ") are shown. Run `print(mo_renamed(), n = ...)` to view more entries (might be slow), or save `mo_renamed()` to an object."), "")
|
|
)
|
|
}
|
|
|
|
# UNDOCUMENTED HELPER FUNCTIONS -------------------------------------------
|
|
|
|
convert_colloquial_input <- function(x) {
|
|
x.bak <- trimws2(x)
|
|
x <- trimws2(tolower(x))
|
|
out <- rep(NA_character_, length(x))
|
|
|
|
# Streptococci, like GBS = Group B Streptococci (B_STRPT_GRPB)
|
|
out[x %like_case% "^g[abcdefghijkl]s$"] <- gsub("g([abcdefghijkl])s",
|
|
"B_STRPT_GRP\\U\\1",
|
|
x[x %like_case% "^g[abcdefghijkl]s$"],
|
|
perl = TRUE
|
|
)
|
|
# Streptococci in different languages, like "estreptococos grupo B"
|
|
out[x %like_case% "strepto[ck]o[ck][a-zA-Z ]* [abcdefghijkl]$"] <- gsub(".*e?strepto[ck]o[ck].* ([abcdefghijkl])$",
|
|
"B_STRPT_GRP\\U\\1",
|
|
x[x %like_case% "strepto[ck]o[ck][a-zA-Z ]* [abcdefghijkl]$"],
|
|
perl = TRUE
|
|
)
|
|
out[x %like_case% "strep[a-z]* group [abcdefghijkl]$"] <- gsub(".* ([abcdefghijkl])$",
|
|
"B_STRPT_GRP\\U\\1",
|
|
x[x %like_case% "strep[a-z]* group [abcdefghijkl]$"],
|
|
perl = TRUE
|
|
)
|
|
out[x %like_case% "group [abcdefghijkl] strepto[ck]o[ck]"] <- gsub(".*group ([abcdefghijkl]) strepto[ck]o[ck].*",
|
|
"B_STRPT_GRP\\U\\1",
|
|
x[x %like_case% "group [abcdefghijkl] strepto[ck]o[ck]"],
|
|
perl = TRUE
|
|
)
|
|
out[x %like_case% "ha?emoly.*strep"] <- "B_STRPT_HAEM"
|
|
out[x %like_case% "(strepto.* [abcg, ]{2,4}$)"] <- "B_STRPT_ABCG"
|
|
out[x %like_case% "(strepto.* mil+er+i|^mgs[^a-z]*$)"] <- "B_STRPT_MILL"
|
|
out[x %like_case% "mil+er+i gr"] <- "B_STRPT_MILL"
|
|
out[x %like_case% "((strepto|^s).* viridans|^vgs[^a-z]*$)"] <- "B_STRPT_VIRI"
|
|
out[x %like_case% "(viridans.* (strepto|^s).*|^vgs[^a-z]*$)"] <- "B_STRPT_VIRI"
|
|
|
|
# Salmonella in different languages, like "Salmonella grupo B"
|
|
out[x %like_case% "salmonella.* [abcdefgh]$"] <- gsub(".*salmonella.* ([abcdefgh])$",
|
|
"B_SLMNL_GRP\\U\\1",
|
|
x[x %like_case% "salmonella.* [abcdefgh]$"],
|
|
perl = TRUE
|
|
)
|
|
out[x %like_case% "group [abcdefgh] salmonella"] <- gsub(".*group ([abcdefgh]) salmonella*",
|
|
"B_SLMNL_GRP\\U\\1",
|
|
x[x %like_case% "group [abcdefgh] salmonella"],
|
|
perl = TRUE
|
|
)
|
|
|
|
# CoNS/CoPS in different languages (support for German, Dutch, Spanish, Portuguese)
|
|
out[x %like_case% "([ck]oagulas[ea].negatie?[vf]|^[ck]o?ns[^a-z]*$)"] <- "B_STPHY_CONS"
|
|
out[x %like_case% "([ck]oagulas[ea].positie?[vf]|^[ck]o?ps[^a-z]*$)"] <- "B_STPHY_COPS"
|
|
|
|
# Gram stains
|
|
out[x %like_case% "gram[ -]?neg.*"] <- "B_GRAMN"
|
|
out[x %like_case% "( |^)gram[-]( |$)"] <- "B_GRAMN"
|
|
out[x %like_case% "gram[ -]?pos.*"] <- "B_GRAMP"
|
|
out[x %like_case% "( |^)gram[+]( |$)"] <- "B_GRAMP"
|
|
out[x %like_case% "anaerob[a-z]+ .*gram[ -]?neg.*"] <- "B_ANAER-NEG"
|
|
out[x %like_case% "anaerob[a-z]+ .*gram[ -]?pos.*"] <- "B_ANAER-POS"
|
|
out[is.na(out) & x %like_case% "anaerob[a-z]+ (micro)?.*organism"] <- "B_ANAER"
|
|
|
|
# coryneform bacteria
|
|
out[x %like_case% "^coryneform"] <- "B_CORYNF"
|
|
|
|
# yeasts and fungi
|
|
out[x %like_case% "^yeast?"] <- "F_YEAST"
|
|
out[x %like_case% "^fung(us|i)"] <- "F_FUNGUS"
|
|
|
|
# trivial names known to the field
|
|
out[x %like_case% "meningo[ck]o[ck]"] <- "B_NESSR_MNNG"
|
|
out[x %like_case% "gono[ck]o[ck]"] <- "B_NESSR_GNRR"
|
|
out[x %like_case% "pneumo[ck]o[ck]"] <- "B_STRPT_PNMN"
|
|
out[x %like_case% "hacek"] <- "B_HACEK"
|
|
out[x %like_case% "haemophilus" & x %like_case% "aggregatibacter" & x %like_case% "cardiobacterium" & x %like_case% "eikenella" & x %like_case% "kingella"] <- "B_HACEK"
|
|
out[x %like_case% "slow.* grow.* mycobact"] <- "B_MYCBC_SGM"
|
|
out[x %like_case% "rapid.* grow.* mycobact"] <- "B_MYCBC_RGM"
|
|
|
|
# unexisting names (con is the WHONET code for contamination)
|
|
out[x %in% c("con", "other", "none", "unknown") | x %like_case% "virus"] <- "UNKNOWN"
|
|
|
|
# WHONET has a lot of E. coli and Vibrio cholerae names
|
|
out[x %like_case% "escherichia coli"] <- "B_ESCHR_COLI"
|
|
out[x %like_case% "vibrio cholerae"] <- "B_VIBRI_CHLR"
|
|
|
|
out
|
|
}
|
|
|
|
italicise <- function(x) {
|
|
if (!has_colour()) {
|
|
return(x)
|
|
}
|
|
out <- font_italic(x, collapse = NULL)
|
|
# city-like serovars of Salmonella (start with a capital)
|
|
out[x %like_case% "Salmonella [A-Z]"] <- paste(
|
|
font_italic("Salmonella"),
|
|
gsub("Salmonella ", "", x[x %like_case% "Salmonella [A-Z]"])
|
|
)
|
|
# streptococcal groups
|
|
out[x %like_case% "Streptococcus [A-Z]"] <- paste(
|
|
font_italic("Streptococcus"),
|
|
gsub("Streptococcus ", "", x[x %like_case% "Streptococcus [A-Z]"])
|
|
)
|
|
# be sure not to make these italic
|
|
out <- gsub("([ -]*)(Group|group|Complex|complex)(\033\\[23m)?", "\033[23m\\1\\2", out, perl = TRUE)
|
|
out <- gsub("(\033\\[3m)?(Beta[-]haemolytic|Coagulase[-](postive|negative)) ", "\\2 \033[3m", out, perl = TRUE)
|
|
out
|
|
}
|
|
|
|
nr2char <- function(x) {
|
|
if (x %in% c(1:10)) {
|
|
v <- c(
|
|
"one" = 1, "two" = 2, "three" = 3, "four" = 4, "five" = 5,
|
|
"six" = 6, "seven" = 7, "eight" = 8, "nine" = 9, "ten" = 10
|
|
)
|
|
names(v[x])
|
|
} else {
|
|
x
|
|
}
|
|
}
|
|
|
|
parse_and_convert <- function(x) {
|
|
if (tryCatch(is.character(x) && all(Encoding(x) == "unknown", na.rm = TRUE), error = function(e) FALSE)) {
|
|
out <- x
|
|
} else {
|
|
out <- tryCatch(
|
|
{
|
|
if (!is.null(dim(x))) {
|
|
if (NCOL(x) > 2) {
|
|
stop("a maximum of two columns is allowed", call. = FALSE)
|
|
} else if (NCOL(x) == 2) {
|
|
# support Tidyverse selection like: df %>% select(colA, colB)
|
|
# paste these columns together
|
|
x <- as.data.frame(x, stringsAsFactors = FALSE)
|
|
colnames(x) <- c("A", "B")
|
|
x <- paste(x$A, x$B)
|
|
} else {
|
|
# support Tidyverse selection like: df %>% select(colA)
|
|
x <- as.data.frame(x, stringsAsFactors = FALSE)[[1]]
|
|
}
|
|
}
|
|
parsed <- iconv(as.character(x), to = "UTF-8")
|
|
parsed[is.na(parsed) & !is.na(x)] <- iconv(x[is.na(parsed) & !is.na(x)], from = "Latin1", to = "ASCII//TRANSLIT")
|
|
parsed <- gsub('"', "", parsed, fixed = TRUE)
|
|
parsed
|
|
},
|
|
error = function(e) stop(e$message, call. = FALSE)
|
|
) # this will also be thrown when running `as.mo(no_existing_object)`
|
|
}
|
|
out <- trimws2(out)
|
|
out <- gsub(" +", " ", out, perl = TRUE)
|
|
out <- gsub(" ?/ ? ", "/", out, perl = TRUE)
|
|
out
|
|
}
|
|
|
|
replace_old_mo_codes <- function(x, property) {
|
|
# this function transform old MO codes to current codes, such as:
|
|
# B_ESCH_COL (AMR v0.5.0) -> B_ESCHR_COLI
|
|
ind <- x %like_case% "^[A-Z]_[A-Z_]+$" & !x %in% AMR_env$MO_lookup$mo
|
|
if (any(ind, na.rm = TRUE)) {
|
|
add_MO_lookup_to_AMR_env()
|
|
# get the ones that match
|
|
affected <- x[ind]
|
|
affected_unique <- unique(affected)
|
|
all_direct_matches <- TRUE
|
|
# find their new codes, once per code
|
|
solved_unique <- unlist(lapply(
|
|
strsplit(affected_unique, ""),
|
|
function(m) {
|
|
kingdom <- paste0("^", m[1])
|
|
name <- m[3:length(m)]
|
|
name[name == "_"] <- " "
|
|
name <- tolower(paste0(name, ".*", collapse = ""))
|
|
name <- gsub(" .*", " ", name, fixed = TRUE)
|
|
name <- paste0("^", name)
|
|
results <- AMR_env$MO_lookup$mo[AMR_env$MO_lookup$kingdom %like_case% kingdom &
|
|
AMR_env$MO_lookup$fullname_lower %like_case% name]
|
|
if (length(results) > 1) {
|
|
all_direct_matches <<- FALSE
|
|
}
|
|
results[1L]
|
|
}
|
|
), use.names = FALSE)
|
|
solved <- solved_unique[match(affected, affected_unique)]
|
|
# assign on places where a match was found
|
|
x[ind] <- solved
|
|
n_matched <- length(affected[!is.na(affected)])
|
|
n_solved <- length(affected[!is.na(solved)])
|
|
n_unsolved <- length(affected[is.na(solved)])
|
|
n_unique <- length(affected_unique[!is.na(affected_unique)])
|
|
if (n_unique < n_matched) {
|
|
n_unique <- paste0(n_unique, " unique, ")
|
|
} else {
|
|
n_unique <- ""
|
|
}
|
|
if (property != "mo") {
|
|
warning_(
|
|
"in `mo_", property, "()`: the input contained ", n_matched,
|
|
" old MO code", ifelse(n_matched == 1, "", "s"),
|
|
" (", n_unique, "from a previous AMR package version). ",
|
|
"Please update your MO codes with `as.mo()` to increase speed."
|
|
)
|
|
} else {
|
|
warning_(
|
|
"in `as.mo()`: the input contained ", n_matched,
|
|
" old MO code", ifelse(n_matched == 1, "", "s"),
|
|
" (", n_unique, "from a previous AMR package version). ",
|
|
n_solved, " old MO code", ifelse(n_solved == 1, "", "s"),
|
|
ifelse(n_solved == 1, " was", " were"),
|
|
ifelse(all_direct_matches, " updated ", font_bold(" guessed ")),
|
|
"to ", ifelse(n_solved == 1, "a ", ""),
|
|
"currently used MO code", ifelse(n_solved == 1, "", "s"),
|
|
ifelse(n_unsolved > 0,
|
|
paste0(" and ", n_unsolved, " old MO code", ifelse(n_unsolved == 1, "", "s"), " could not be updated."),
|
|
"."
|
|
)
|
|
)
|
|
}
|
|
}
|
|
x
|
|
}
|
|
|
|
replace_ignore_pattern <- function(x, ignore_pattern) {
|
|
if (!is.null(ignore_pattern) && !identical(trimws2(ignore_pattern), "")) {
|
|
ignore_cases <- x %like% ignore_pattern
|
|
if (sum(ignore_cases) > 0) {
|
|
message_(
|
|
"The following input was ignored by `ignore_pattern = \"", ignore_pattern, "\"`: ",
|
|
vector_and(x[ignore_cases], quotes = TRUE)
|
|
)
|
|
x[ignore_cases] <- NA_character_
|
|
}
|
|
}
|
|
x
|
|
}
|
|
|
|
repair_reference_df <- function(reference_df) {
|
|
if (is.null(reference_df)) {
|
|
return(NULL)
|
|
}
|
|
# has valid own reference_df
|
|
reference_df <- reference_df %pm>%
|
|
pm_filter(!is.na(mo))
|
|
|
|
# keep only first two columns, second must be mo
|
|
if (colnames(reference_df)[1] == "mo") {
|
|
reference_df <- reference_df %pm>% pm_select(2, "mo")
|
|
} else {
|
|
reference_df <- reference_df %pm>% pm_select(1, "mo")
|
|
}
|
|
|
|
# remove factors, just keep characters
|
|
colnames(reference_df)[1] <- "x"
|
|
reference_df[, "x"] <- as.character(reference_df[, "x", drop = TRUE])
|
|
reference_df[, "mo"] <- as.character(reference_df[, "mo", drop = TRUE])
|
|
|
|
# some MO codes might be old
|
|
reference_df[, "mo"] <- as.mo(reference_df[, "mo", drop = TRUE], reference_df = NULL)
|
|
reference_df
|
|
}
|
|
|
|
get_mo_uncertainties <- function() {
|
|
remember <- list(uncertainties = AMR_env$mo_uncertainties)
|
|
# empty them, otherwise e.g. mo_shortname("Chlamydophila psittaci") will give 3 notes
|
|
AMR_env$mo_uncertainties <- NULL
|
|
remember
|
|
}
|
|
|
|
load_mo_uncertainties <- function(metadata) {
|
|
AMR_env$mo_uncertainties <- metadata$uncertainties
|
|
}
|
|
|
|
synonym_mo_to_accepted_mo <- function(x, fill_in_accepted = FALSE) {
|
|
x_gbif <- AMR_env$MO_lookup$gbif_renamed_to[match(x, AMR_env$MO_lookup$mo)]
|
|
x_lpsn <- AMR_env$MO_lookup$lpsn_renamed_to[match(x, AMR_env$MO_lookup$mo)]
|
|
x_gbif[!x_gbif %in% AMR_env$MO_lookup$gbif] <- NA
|
|
x_lpsn[!x_lpsn %in% AMR_env$MO_lookup$lpsn] <- NA
|
|
|
|
out <- ifelse(is.na(x_lpsn),
|
|
AMR_env$MO_lookup$mo[match(x_gbif, AMR_env$MO_lookup$gbif)],
|
|
AMR_env$MO_lookup$mo[match(x_lpsn, AMR_env$MO_lookup$lpsn)]
|
|
)
|
|
if (isTRUE(fill_in_accepted)) {
|
|
x_accepted <- which(AMR_env$MO_lookup$status[match(x, AMR_env$MO_lookup$mo)] == "accepted")
|
|
out[x_accepted] <- x[x_accepted]
|
|
}
|
|
out
|
|
}
|