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When a base beta-lactam column (e.g., piperacillin/PIP) is absent but a corresponding drug+inhibitor combination (e.g., piperacillin/tazobactam/TZP) is present and resistant, resistance in the base drug is now correctly inferred. This is clinically sound: resistance in a combination implies the inhibitor provided no benefit, so the base drug is also resistant. Susceptibility in a combination is NOT propagated to the base drug (the inhibitor may be responsible for susceptibility), so only R values are inferred; missing base drugs remain NA otherwise. Implementation details: - Uses AB_BETALACTAMS_WITH_INHIBITOR to identify all beta-lactam+inhibitor combinations present in the user's data - Derives base drug AB codes by stripping the "/inhibitor" part from names - Creates synthetic proxy columns (.sir_proxy_<AB>) in x, set to "R" when any matching combination is R, otherwise NA - Proxy columns are added to cols_ab before drug variable assignment, so all existing guideline logic benefits without any changes - Multiple combos for the same base drug are OR-ed (any R → R) - Adds internal ab_without_inhibitor() helper for the name->base mapping - Verbose mode reports which combinations are used for inference Bumps version: 3.0.1.9028 -> 3.0.1.9029 https://claude.ai/code/session_01Cp154UtssHg84bw38xiiTG
75 lines
4.6 KiB
Plaintext
75 lines
4.6 KiB
Plaintext
Package: AMR
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Version: 3.0.1.9029
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Date: 2026-03-06
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Title: Antimicrobial Resistance Data Analysis
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Description: Functions to simplify and standardise antimicrobial resistance (AMR)
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data analysis and to work with microbial and antimicrobial properties by
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using evidence-based methods, as described in <doi:10.18637/jss.v104.i03>.
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Authors@R: c(
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person(given = c("Matthijs", "S."), family = "Berends", role = c("aut", "cre"), comment = c(ORCID = "0000-0001-7620-1800"), email = "m.s.berends@umcg.nl"),
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person(given = c("Dennis"), family = "Souverein", role = c("aut", "ctb"), comment = c(ORCID = "0000-0003-0455-0336")),
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person(given = c("Erwin", "E.", "A."), family = "Hassing", role = c("aut", "ctb")),
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person(given = c("Aislinn"), family = "Cook", role = "ctb", comment = c(ORCID = "0000-0002-9189-7815")),
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person(given = c("Andrew", "P."), family = "Norgan", role = "ctb", comment = c(ORCID = "0000-0002-2955-2066")),
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person(given = c("Anita"), family = "Williams", role = "ctb", comment = c(ORCID = "0000-0002-5295-8451")),
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person(given = c("Annick"), family = "Lenglet", role = "ctb", comment = c(ORCID = "0000-0003-2013-8405")),
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person(given = c("Anthony"), family = "Underwood", role = "ctb", comment = c(ORCID = "0000-0002-8547-4277")),
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person(given = c("Anton"), family = "Mymrikov", role = "ctb"),
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person(given = c("Bart", "C."), family = "Meijer", role = "ctb"),
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person(given = c("Christian", "F."), family = "Luz", role = "ctb", comment = c(ORCID = "0000-0001-5809-5995")),
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person(given = c("Dmytro"), family = "Mykhailenko", role = "ctb"),
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person(given = c("Eric", "H.", "L.", "C.", "M."), family = "Hazenberg", role = "ctb"),
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person(given = c("Gwen"), family = "Knight", role = "ctb", comment = c(ORCID = "0000-0002-7263-9896")),
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person(given = c("Jane"), family = "Hawkey", role = "ctb", comment = c(ORCID = "0000-0001-9661-5293")),
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person(given = c("Jason"), family = "Stull", role = "ctb", comment = c(ORCID = "0000-0002-9028-8153")),
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person(given = c("Javier"), family = "Sanchez", role = "ctb", comment = c(ORCID = "0000-0003-2605-8094")),
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person(given = c("Jonas"), family = "Salm", role = "ctb"),
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person(given = c("Judith", "M."), family = "Fonville", role = "ctb"),
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person(given = c("Kathryn"), family = "Holt", role = "ctb", comment = c(ORCID = "0000-0003-3949-2471")),
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person(given = c("Larisse"), family = "Bolton", role = "ctb", comment = c(ORCID = "0000-0001-7879-2173")),
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person(given = c("Matthew"), family = "Saab", role = "ctb", comment = c(ORCID = "0009-0008-6626-7919")),
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person(given = c("Natacha"), family = "Couto", role = "ctb", comment = c(ORCID = "0000-0002-9152-5464")),
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person(given = c("Peter"), family = "Dutey-Magni", role = "ctb", comment = c(ORCID = "0000-0002-8942-9836")),
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person(given = c("Rogier", "P."), family = "Schade", role = "ctb", comment = c(ORCID = "0000-0002-9487-4467")),
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person(given = c("Sofia"), family = "Ny", role = "ctb", comment = c(ORCID = "0000-0002-2017-1363")),
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person(given = c("Alex", "W."), family = "Friedrich", role = "ths", comment = c(ORCID = "0000-0003-4881-038X")),
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person(given = c("Bhanu", "N.", "M."), family = "Sinha", role = "ths", comment = c(ORCID = "0000-0003-1634-0010")),
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person(given = c("Casper", "J."), family = "Albers", role = "ths", comment = c(ORCID = "0000-0002-9213-6743")),
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person(given = c("Corinna"), family = "Glasner", role = "ths", comment = c(ORCID = "0000-0003-1241-1328")))
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Depends: R (>= 3.0.0)
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Suggests:
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cleaner,
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cli,
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crayon,
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curl,
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data.table,
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dplyr,
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ggplot2,
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knitr,
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openxlsx,
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parallelly,
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pillar,
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progress,
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readxl,
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recipes,
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rlang,
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rmarkdown,
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rstudioapi,
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rvest,
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skimr,
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testthat,
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tibble,
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tidymodels,
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tidyselect,
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tinytest,
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vctrs,
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xml2
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VignetteBuilder: knitr,rmarkdown
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URL: https://amr-for-r.org, https://github.com/msberends/AMR
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BugReports: https://github.com/msberends/AMR/issues
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License: GPL-2 | file LICENSE
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Encoding: UTF-8
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LazyData: true
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RoxygenNote: 7.3.3
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Roxygen: list(markdown = TRUE, old_usage = TRUE)
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