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style="font-style:italic;font-variant:normal;font-weight:300;font-size:7.44000006px;font-family:HelveticaNeue;-inkscape-font-specification:HelveticaNeue-LightItalic;writing-mode:lr-tb;fill:#231f20;fill-opacity:1;fill-rule:nonzero;stroke:none"
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x="0 5.5576801 9.4488001 13.47384 17.36496 19.72344 23.614559 24.9984 27.0816 28.748159 32.773201 34.990318 37.348801 41.515202 45.82296 49.848 53.73912 55.956242 57.34008 61.506481">General Introduction</tspan></text>
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x="0 5.6127362 9.1609917 11.561088 16.025663 21.638399 26.224417 28.624512 32.636448 38.249184 42.835201 47.421215 49.942753 54.528767 58.540703 60.9408 63.462337 69.075073 71.475166 74.681183 80.293922 84.879936 87.280029 92.892769 96.562462 102.0648 106.65082 110.32051 112.72061 118.33334 121.8816">of any species in the order of </tspan></text>
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id="tspan334"
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x="0 7.3316641 9.8498878 13.052592 18.662016 21.0588 25.531103 34.010929 39.620354 44.666737 47.184959 51.767666 54.285889 56.804111 59.322334 61.840561 67.449982 72.949005 77.531715 80.049934 84.52224 89.679024 95.06765 97.585869 102.05817 107.6676 110.18582 114.76853 117.16531 121.63762 126.22032 128.73854 134.23756">with amoxicillin/clavulanic acid </tspan></text>
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x="0 4.699728 10.315776 15.931824 20.510113 23.057039 28.551647 31.076496 35.544384 44.03083 48.609119 51.818447 56.396736 60.069744 62.616673 68.232719 71.784286 74.331215 79.483582">zone diameter of 19</tspan></text>
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y="0"
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x="0">-</tspan></text>
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id="g374"
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id="tspan370"
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y="0"
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x="0 5.1567841 10.313568 12.864912 21.344736">20 mm</tspan></text>
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transform="translate(-28.05536,-28.34277)" /><g
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style="font-variant:normal;font-weight:normal;font-size:11.03999996px;font-family:Garamond;-inkscape-font-specification:Garamond;writing-mode:lr-tb;fill:#231f20;fill-opacity:1;fill-rule:nonzero;stroke:none"
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transform="matrix(1,0,0,-1,257.6962,640.2834)"><tspan
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id="tspan378"
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y="0"
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x="0 2.5193281 8.1298561 10.682304 13.886112 19.496639 24.080448 26.632896 29.152224 33.625633 36.829441 41.413246 45.422977 48.626785 51.179234 58.4016 66.198051 73.188576 80.642784 85.911072 92.669762 95.222206 97.741539 103.35207 106.55587 111.13968 114.80717 120.41769 124.08518 128.66899 131.8728 136.34621 139.55002 142.06935 147.67987 153.29041 155.84285 160.76889 166.15863 168.67795 174.17809 178.76189 181.28122 183.80054 189.41107 193.99487">in the latest EUCAST interpretation guideline </tspan></text>
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id="tspan384"
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y="0"
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x="0 1.897296 5.1796322 8.4619684">[24]</tspan></text>
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id="tspan390"
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y="0"
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x="0 2.4067199">. </tspan></text>
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id="text398"
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transform="matrix(1,0,0,-1,70.79691,624.9234)"><tspan
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id="tspan396"
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y="0"
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x="0 7.2190561 15.012192 21.999409 29.450304 34.715279 41.481697 45.057552 49.527649 55.024464 60.179039 62.695057 66.712509 71.293007 75.310463 78.886322 82.097855 87.71611 91.291969 94.956146 99.536636 103.20081 108.58723 114.20549 117.78134 120.99288 126.61114 131.19164 134.76749 137.97902 142.55952 146.57698 149.78851 152.19412 155.76999 161.38824 165.96873 169.63292 173.18669 178.80495 182.46912 190.94673 194.5226 198.99269 204.61095 208.1868 212.65689 218.15372 223.65053 226.16655 229.37808 231.89409 237.51236 243.13062 247.60071 250.11671 253.69258 256.90411 261.48462 265.50208 268.71359 271.1192 274.69507 280.31332 283.97751 287.55338 290.76489 296.38315 299.95901 303.62317 308.20367 313.82193 319.44019 323.10437 326.31592 329.89175 333.1033 338.72156 341.23758 345.25504 348.83087 354.21729 359.83554 364.41605 368.99655 372.66071 375.87225 380.34235 382.85837 388.47662 391.68817 396.26865">EUCAST advises to rerun the test, perform an additional test, or to report this uncertainty </tspan></text>
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</g><g
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style="font-variant:normal;font-weight:normal;font-size:11.03999996px;font-family:Garamond;-inkscape-font-specification:Garamond;writing-mode:lr-tb;fill:#231f20;fill-opacity:1;fill-rule:nonzero;stroke:none"
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transform="matrix(1,0,0,-1,70.79691,609.3239)"><tspan
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y="0"
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x="0 7.3316641 9.8498878 13.052592 18.662016 21.412081 25.884384 28.634447 33.217152 35.735374 40.318081 44.790382 48.456768 51.206833 58.538494 63.010799 66.677185 72.286606 74.804832 80.414253 85.339203">with a clear warning </tspan></text>
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x="0 1.897296 5.1796322 8.4619684">[23]</tspan></text>
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x="0 2.4067199">. </tspan></text>
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style="font-variant:normal;font-weight:bold;font-size:9.11999989px;font-family:Garamond;-inkscape-font-specification:Garamond-Bold;writing-mode:lr-tb;fill:#231f20;fill-opacity:1;fill-rule:nonzero;stroke:none"
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transform="matrix(1,0,0,-1,70.8,115.88)"><tspan
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id="tspan424"
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y="0"
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x="0 5.5331039 8.0657282 12.942192 17.909857 21.007919 25.227743">Figure </tspan></text>
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</g><g
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transform="matrix(1,0,0,-1,98.44272,115.88)"><tspan
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id="tspan430"
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y="0"
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x="0 4.2189121">3.</tspan></text>
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</g><g
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transform="matrix(1,0,0,-1,107.4259,115.88)"><tspan
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y="0"
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x="0 3.185616 7.775712 10.395888 14.146944 17.15016 21.740255 24.743471 28.494528 31.114704 34.774559 37.394737 39.458591 44.048687 48.638783 51.058319 55.648415 58.551311 60.970848 65.187027 69.403198 73.619377 76.03891 79.04213 82.701981 87.292084 91.790977 96.381073 103.32413 105.74367 112.68672 114.75057 119.34068 121.40453 128.34758 132.75528 139.69833 142.11787 144.18173 148.77182 153.36192 155.42578 160.01587 162.07973 164.69991 169.28999 172.29321 176.04427 178.46381 182.21486 186.80496 191.39505 195.14612 198.89717 203.48726 206.10744 209.11066 212.77051 215.39069 217.45454 222.04465 226.63474 229.92067 232.34021 234.96039 237.58057 242.17065 246.76076 249.38092 251.80046 255.46033 260.05042 264.54932 266.96884 271.18503 275.40121 279.61737 282.03693 285.04013 288.69998 293.29007 297.78897 302.37906 309.32211 311.74167 316.24057 318.30441 321.59036 325.80652 328.22607 332.72495 334.78882 337.69171 340.5946 345.00229 348.28824 350.35208 354.9422 359.53229">Interpretation of 100 random minimum inhibitory concentrations (top) and 100 random disk diffusion </tspan></text>
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</g><g
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id="tspan444"
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y="0"
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x="0 4.030128 7.029696 11.625264 17.625313 20.250959 24.846527 28.137936 30.198145 34.793713 39.389278 41.44949 46.045055 48.105263 50.730911 52.791119 57.386688 61.982258 65.273666 69.121391 73.716957 78.312531 82.059937 85.342224 88.633629 91.259277 95.854851 100.45042 103.07607 105.70171 110.29728 117.23669 119.86234 123.15375 127.74931 130.65768 133.94908 137.6965 139.7567 144.35226 147.35184 151.9474 154.85577 156.91599 161.51155 165.642 169.2982 173.04561 175.10582 179.70139 182.9928 185.05301 189.64857">growth inhibition zones (bottom) of ciprofloxacin in </tspan></text>
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</g><g
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style="font-style:italic;font-variant:normal;font-size:9.11999989px;font-family:Garamond;-inkscape-font-specification:Garamond-Italic;writing-mode:lr-tb;fill:#231f20;fill-opacity:1;fill-rule:nonzero;stroke:none"
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transform="matrix(1,0,0,-1,263.6424,105.5562)"><tspan
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id="tspan450"
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y="0"
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x="0 6.1879201 8.8099203 11.24952 15.0024 17.624399 20.34672 22.412399 24.851999 28.604879 30.670561 34.32312 37.610882 40.05048 43.237919 45.203281">Escherichia coli</tspan></text>
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</g><g
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transform="matrix(1,0,0,-1,310.8931,105.5562)"><tspan
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id="tspan456"
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y="0"
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x="0 1.969008 5.260416 7.3206239 11.916192 14.54184 18.289248 21.288816 25.884384 28.883951 32.631359 35.257008 39.004417 43.508785 46.800194 51.204239 54.486526">, interpreted usi</tspan></text>
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transform="matrix(1,0,0,-1,367.428,105.5562)"><tspan
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id="tspan462"
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transform="matrix(1,0,0,-1,70.79999,95.47856)"><tspan
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id="tspan468"
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y="0"
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x="0 5.9061122 12.286464 18.001057 24.098688 28.4088 33.94099 36.189983 40.408897 44.627808 48.846722 53.065632 55.314625 59.342014 63.752449 65.809921 70.311554 74.056221 76.113693 78.171165 82.764 86.508675 88.474945 90.723938 96.256126 100.84896 104.59364 107.87318 111.61786 113.86685 118.45968 120.51715 125.10999 127.73289 131.01245 133.26144 139.25876 143.00342 146.00937 149.75404 152.00304 156.03043 159.7751 164.36794 168.11261 171.11856 174.77203 177.39494 181.13962 185.64125 187.89024 193.88756 195.94502 198.56793 203.16077 205.40976 208.03267 212.6255 216.37018 218.61917 224.7168 232.21892 237.8423 240.09129 244.68413 248.3376 252.08228 256.30118 259.95465 263.98206 267.72672 269.97571 272.88135 277.47418 280.48013 282.72913 288.35251">EUCAST 2021 guideline. These plots were generated with the AMR package for R.</tspan></text>
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</g><g
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transform="matrix(1,0,0,-0.99992962,215.6152,379.164)"><tspan
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id="tspan634"
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x="0 13.996477 27.992102 41.988579 55.985058 74.60582 79.346054 95.600113 100.34035 116.5944 121.33463 137.58868 142.32892">0246811141720</tspan></text>
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id="tspan640"
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x="0 4.6166124 6.0361247 9.5913 11.720569 15.275743 17.053331 18.472843 21.836193 25.033293 28.588469 31.785568 33.205082">Ciprofloxacin</tspan></text>
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x="0">−</tspan></text>
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style="font-style:italic;font-variant:normal;font-size:6.39419985px;font-family:Helvetica;-inkscape-font-specification:Helvetica-Oblique;writing-mode:lr-tb;fill:#231f20;fill-opacity:1;fill-rule:nonzero;stroke:none"
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transform="matrix(1,0,0,-0.99993744,268.3443,588.1552)"><tspan
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id="tspan656"
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y="0"
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x="0 4.2649312 7.4620314 10.659131 14.214307 17.769482 19.994663 21.414175 24.611277 28.166451 29.585964 33.14114 34.918728 38.115826 41.671001 43.090515">Escherichia coli</tspan></text>
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</g><g
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id="g662"
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transform="translate(-28.05536,-28.34277)" /><g
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id="g668"
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transform="translate(-28.05536,-28.34277)"><text
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id="text666"
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style="font-variant:normal;font-weight:normal;font-size:6.39419985px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#231f20;fill-opacity:1;fill-rule:nonzero;stroke:none"
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transform="matrix(1,0,0,-0.99993744,314.4528,588.1552)"><tspan
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id="tspan664"
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y="0"
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x="0 2.1292686 6.3941998 11.010813 15.627425 19.892357 24.157288 28.064144 29.841732 33.396908 36.952084 40.507256 44.062431">(EUCAST 2021)</tspan></text>
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|
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</g></g></g><g
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id="g698"><g
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clip-path="url(#clipPath62)"><g
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id="g676"
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d="m 197.97,282.2 h 228.29 v 18.76 H 197.97 Z" /></g><g
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d="m 355.5,289.24 h 6.4 v 4.69 h -6.4 z" /></g><g
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id="g694"
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transform="translate(-28.05536,-28.34277)"><text
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id="text692"
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style="font-variant:normal;font-weight:normal;font-size:6.39419985px;font-family:Helvetica;-inkscape-font-specification:Helvetica;writing-mode:lr-tb;fill:#231f20;fill-opacity:1;fill-rule:nonzero;stroke:none"
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transform="matrix(1,0,0,-0.99993744,224.6314,570.7144)"><tspan
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id="tspan690"
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y="0"
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x="0 4.2649312 7.8201065 11.017206 14.214307 17.769482 21.324657 23.102245 24.521757 27.949049 29.368561 53.121735 54.899323 58.454498 61.651596 63.461155 65.238747 67.016335 70.379677 73.576782 77.131958 80.687134 83.884232 87.439407 89.568672 106.23579 110.85241 114.40759 117.60468 119.02419 122.2213 123.99889 127.55406 131.10924">SusceptibleIncr. exposureResistant</tspan></text>
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</g></g></g><g
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id="g870"><g
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d="m 77.79,73.44 h 26.33 V 223.87 H 77.79 Z" /></g><g
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id="tspan762"
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x="0 4.7670884 22.570791 27.337881 45.148441 49.915531 67.726952 72.494041 90.297745 95.064835 112.8754 117.64248 135.44618 140.21327 158.02383 162.79092 180.59464 185.36171 203.17314 207.94023 225.74393 230.51102 248.32158 253.08867 270.89923 275.66632 293.47003 298.23712 316.04852 320.81561">171819202122232425262728293031</tspan></text>
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transform="matrix(1,0,0,-0.99993002,239.3626,136.0855)"><tspan
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id="tspan768"
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x="0 6.1903558 8.0937614 12.380712 16.667662 19.051207 23.818295 25.721701 28.105244 30.488789 35.255878 39.542828 41.446232 46.213322 50.980408 53.363953 58.131042 60.034447 64.801537 71.943596 76.710686 79.094231 83.861313 86.716423 89.099968 91.955078 99.097137 106.2392">Disk diffusion diameter (mm)</tspan></text>
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x="0 2.1413231 6.4303999 11.073149 15.715898 20.004974 24.294052 28.223026 30.010677 33.585979 37.161282 40.736584 44.311886">(EUCAST 2021)</tspan></text>
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