From 0ef4856e745af78a85ff4ee85efa88b30824ce0d Mon Sep 17 00:00:00 2001
From: Matthijs Berends <berendsms@gmail.com>
Date: Fri, 10 Sep 2021 22:22:38 +0200
Subject: [PATCH] Preamble

---
 01-introduction.Rmd                           |   4 +-
 0a. Title page.pdf                            | Bin 41599 -> 0 bytes
 .../figure-latex/nice-fig-1.pdf               | Bin 0 -> 5848 bytes
 docs/404.html                                 |   9 +-
 ...instrument_for_microbial_epidemiology.epub | Bin 0 -> 15830 bytes
 ..._instrument_for_microbial_epidemiology.pdf | Bin 0 -> 47929 bytes
 ..._instrument_for_microbial_epidemiology.tex | 242 +++++++++++
 docs/colophon.html                            | 237 +++++++++++
 docs/index.html                               |  26 +-
 docs/introduction.html                        | 400 ++++++++++++++++++
 docs/reference-keys.txt                       |   2 +-
 docs/search_index.json                        |   2 +-
 index.Rmd                                     |  24 +-
 13 files changed, 926 insertions(+), 20 deletions(-)
 delete mode 100644 0a. Title page.pdf
 create mode 100644 _bookdown_files/a_new_instrument_for_microbial_epidemiology_files/figure-latex/nice-fig-1.pdf
 create mode 100644 docs/a_new_instrument_for_microbial_epidemiology.epub
 create mode 100644 docs/a_new_instrument_for_microbial_epidemiology.pdf
 create mode 100644 docs/a_new_instrument_for_microbial_epidemiology.tex
 create mode 100644 docs/colophon.html
 create mode 100644 docs/introduction.html

diff --git a/01-introduction.Rmd b/01-introduction.Rmd
index 330dc5b..03d6b48 100644
--- a/01-introduction.Rmd
+++ b/01-introduction.Rmd
@@ -1,6 +1,6 @@
-# Introduction {#intro}
+# Introduction {#introduction}
 
-You can label chapter and section titles using `{#label}` after them, e.g., we can reference Chapter \@ref(intro). If you do not manually label them, there will be automatic labels anyway, e.g., Chapter \@ref(methods).
+You can label chapter and section titles using `{#label}` after them, e.g., we can reference Chapter \@ref(introduction).
 
 Figures and tables with captions will be placed in `figure` and `table` environments, respectively.
 
diff --git a/0a. Title page.pdf b/0a. Title page.pdf
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 <meta name="author" content="Matthijs S. Berends" />
 
 
-<meta name="date" content="2021-08-25" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1" />
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 <li><a href="./">A New Instrument for Microbial Epidemiology</a></li>
 
 <li class="divider"></li>
-<li class="chapter" data-level="" data-path="index.html"><a href="index.html"><i class="fa fa-check"></i>Prerequisites</a></li>
-<li class="chapter" data-level="1" data-path="intro.html"><a href="intro.html"><i class="fa fa-check"></i><b>1</b> Introduction</a></li>
+<li class="chapter" data-level="" data-path="index.html"><a href="index.html"><i class="fa fa-check"></i>Preamble</a>
+<ul>
+<li class="chapter" data-level="" data-path="index.html"><a href="index.html#short-summary-250-words"><i class="fa fa-check"></i>Short summary (250 words)</a></li>
+</ul></li>
+<li class="chapter" data-level="" data-path="colophon.html"><a href="colophon.html"><i class="fa fa-check"></i>Colophon</a></li>
+<li class="chapter" data-level="1" data-path="introduction.html"><a href="introduction.html"><i class="fa fa-check"></i><b>1</b> Introduction</a></li>
 <li class="divider"></li>
 <li><a href="https://github.com/rstudio/bookdown" target="blank">Published with bookdown</a></li>
 
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+\bibliographystyle{apalike}
+
+\title{A New Instrument for Microbial Epidemiology}
+\usepackage{etoolbox}
+\makeatletter
+\providecommand{\subtitle}[1]{% add subtitle to \maketitle
+  \apptocmd{\@title}{\par {\large #1 \par}}{}{}
+}
+\makeatother
+\subtitle{Empowering Antimicrobial Resistance Data Analysis}
+\author{Matthijs S. Berends}
+\date{}
+
+\begin{document}
+\maketitle
+
+{
+\setcounter{tocdepth}{1}
+\tableofcontents
+}
+\hypertarget{preamble}{%
+\chapter*{Preamble}\label{preamble}}
+\addcontentsline{toc}{chapter}{Preamble}
+
+This is the integral PhD thesis `A New Instrument for Microbial Epidemiology' (DOI \href{https://doi.org/10.33612/diss.177417131}{10.33612/diss.177417131}) by \href{https://www.rug.nl/staff/m.s.berends}{Matthijs S. Berends}, which was defended publicly at the University of Groningen, the Netherlands, on 25 August 2021.
+
+All texts were copied from the printed version `as is'; no modifications were made.
+
+\hypertarget{short-summary-250-words}{%
+\subsection*{Short summary (250 words)}\label{short-summary-250-words}}
+\addcontentsline{toc}{subsection}{Short summary (250 words)}
+
+Treating infectious diseases requires insights into the microorganisms causing infectious diseases. Antimicrobial resistance (AMR) in microorganisms limits treatment possibilities and poses an enormous healthcare problem worldwide. The spread and AMR patterns of microorganisms, risk factors for infection, and preventive and control measures of infectious disease are studied within the field of Microbial Epidemiology, a cross-over field between Epidemiology and Clinical Microbiology. For analysing the spread and AMR patterns of microorganisms, however, no standardised method previously existed. This thesis showcases the development and applied use of a new instrument to analyse AMR data: the AMR package for R. From multiple viewpoints, the AMR package and its advantages are put into perspective: from a technical viewpoint, from an infection management viewpoint and from a clinical viewpoint. These combined provide a common ground for comprehending what the AMR package could yield in the field and how it can set a new empowered starting point for future applications of microbial epidemiology, in clinical and research settings alike. This thesis subsequently elaborates on these multiple viewpoints by illustrating the use of this new instrument in epidemiological research projects in the Dutch-German cross-border region to better understand the occurrence and AMR patterns of microorganisms on a (eu)regional level. In conclusion, this thesis shows the added value of a consistent data-analytical instrument to prepare and analyse AMR data in a full-region approach, that can also be used in clinical settings to obtain novel insights on AMR patterns.
+
+\hypertarget{colophon}{%
+\chapter*{Colophon}\label{colophon}}
+\addcontentsline{toc}{chapter}{Colophon}
+
+Cover design: Matthijs Berends (images used with permission)\\
+Layout: Matthijs Berends\\
+Printing: Gildeprint -- www.gildeprint.nl
+
+The work described within this thesis was supported by (1) the Certe Medical Diagnostics and Advice Foundation, (2) the INTERREG V A (202085) funded project EurHealth-1Health (\url{http://www.eurhealth1health.eu}), part of a Dutch-German cross-border network supported by the European Commission, the Dutch Ministry of Health, Welfare and Sport, the Ministry of Economy, Innovation, Digitalisation and Energy of the German Federal State of North Rhine-Westphalia, and the Ministry for National and European Affairs and Regional Development of the German Federal State of Lower Saxony, (3) the European Union's Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement 713660 (MSCA-COFUND-2015-DP ``Pronkjewail''), and (4) the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) through the ESCMID Study Group for Antimicrobial Stewardship (ESGAP).
+
+Printing of this thesis was financially supported by the Certe Medical Diagnostics and Advice Foundation. This support is greatly appreciated.
+
+\textbf{Copyright © 2021 by Matthias Simeon Berends.} All rights reserved. Any unauthorised reprint or use of this material is prohibited. No parts of this thesis may be reproduced, stored, or transmitted in any form or by any means, without written permission of the author or, when appropriate, the publishers of the publications.
+
+\hypertarget{introduction}{%
+\chapter{Introduction}\label{introduction}}
+
+You can label chapter and section titles using \texttt{\{\#label\}} after them, e.g., we can reference Chapter \ref{introduction}.
+
+Figures and tables with captions will be placed in \texttt{figure} and \texttt{table} environments, respectively.
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+
+\begin{figure}
+
+{\centering \includegraphics[width=0.8\linewidth]{a_new_instrument_for_microbial_epidemiology_files/figure-latex/nice-fig-1} 
+
+}
+
+\caption{Here is a nice figure!}\label{fig:nice-fig}
+\end{figure}
+
+Reference a figure by its code chunk label with the \texttt{fig:} prefix, e.g., see Figure \ref{fig:nice-fig}. Similarly, you can reference tables generated from \texttt{knitr::kable()}, e.g., see Table \ref{tab:nice-tab}.
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+\centering
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+Sepal.Length & Sepal.Width & Petal.Length & Petal.Width & Species\\
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+5.1 & 3.5 & 1.4 & 0.2 & setosa\\
+4.9 & 3.0 & 1.4 & 0.2 & setosa\\
+4.7 & 3.2 & 1.3 & 0.2 & setosa\\
+4.6 & 3.1 & 1.5 & 0.2 & setosa\\
+5.0 & 3.6 & 1.4 & 0.2 & setosa\\
+\addlinespace
+5.4 & 3.9 & 1.7 & 0.4 & setosa\\
+4.6 & 3.4 & 1.4 & 0.3 & setosa\\
+5.0 & 3.4 & 1.5 & 0.2 & setosa\\
+4.4 & 2.9 & 1.4 & 0.2 & setosa\\
+4.9 & 3.1 & 1.5 & 0.1 & setosa\\
+\addlinespace
+5.4 & 3.7 & 1.5 & 0.2 & setosa\\
+4.8 & 3.4 & 1.6 & 0.2 & setosa\\
+4.8 & 3.0 & 1.4 & 0.1 & setosa\\
+4.3 & 3.0 & 1.1 & 0.1 & setosa\\
+5.8 & 4.0 & 1.2 & 0.2 & setosa\\
+\addlinespace
+5.7 & 4.4 & 1.5 & 0.4 & setosa\\
+5.4 & 3.9 & 1.3 & 0.4 & setosa\\
+5.1 & 3.5 & 1.4 & 0.3 & setosa\\
+5.7 & 3.8 & 1.7 & 0.3 & setosa\\
+5.1 & 3.8 & 1.5 & 0.3 & setosa\\
+\bottomrule
+\end{tabular}
+\end{table}
+
+  \bibliography{packages.bib}
+
+\end{document}
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+
+  <meta charset="utf-8" />
+  <meta http-equiv="X-UA-Compatible" content="IE=edge" />
+  <title>Colophon | A New Instrument for Microbial Epidemiology</title>
+  <meta name="description" content="This is the PhD thesis of the author." />
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+<li><a href="./">A New Instrument for Microbial Epidemiology</a></li>
+
+<li class="divider"></li>
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+<ul>
+<li class="chapter" data-level="" data-path="index.html"><a href="index.html#short-summary-250-words"><i class="fa fa-check"></i>Short summary (250 words)</a></li>
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+          <div class="page-inner">
+
+            <section class="normal" id="section-">
+<div id="colophon" class="section level1 unnumbered">
+<h1>Colophon</h1>
+<p>Cover design: Matthijs Berends (images used with permission)<br />
+Layout: Matthijs Berends<br />
+Printing: Gildeprint – www.gildeprint.nl</p>
+<p>The work described within this thesis was supported by (1) the Certe Medical Diagnostics and Advice Foundation, (2) the INTERREG V A (202085) funded project EurHealth-1Health (<a href="http://www.eurhealth1health.eu" class="uri">http://www.eurhealth1health.eu</a>), part of a Dutch-German cross-border network supported by the European Commission, the Dutch Ministry of Health, Welfare and Sport, the Ministry of Economy, Innovation, Digitalisation and Energy of the German Federal State of North Rhine-Westphalia, and the Ministry for National and European Affairs and Regional Development of the German Federal State of Lower Saxony, (3) the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement 713660 (MSCA-COFUND-2015-DP “Pronkjewail”), and (4) the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) through the ESCMID Study Group for Antimicrobial Stewardship (ESGAP).</p>
+<p>Printing of this thesis was financially supported by the Certe Medical Diagnostics and Advice Foundation. This support is greatly appreciated.</p>
+<p><strong>Copyright © 2021 by Matthias Simeon Berends.</strong> All rights reserved. Any unauthorised reprint or use of this material is prohibited. No parts of this thesis may be reproduced, stored, or transmitted in any form or by any means, without written permission of the author or, when appropriate, the publishers of the publications.</p>
+
+</div>
+            </section>
+
+          </div>
+        </div>
+      </div>
+<a href="index.html" class="navigation navigation-prev " aria-label="Previous page"><i class="fa fa-angle-left"></i></a>
+<a href="introduction.html" class="navigation navigation-next " aria-label="Next page"><i class="fa fa-angle-right"></i></a>
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diff --git a/docs/index.html b/docs/index.html
index b0403b1..dc3dd8e 100644
--- a/docs/index.html
+++ b/docs/index.html
@@ -24,7 +24,6 @@
 <meta name="author" content="Matthijs S. Berends" />
 
 
-<meta name="date" content="2021-08-25" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1" />
   <meta name="apple-mobile-web-app-capable" content="yes" />
@@ -32,7 +31,7 @@
   
   
 
-<link rel="next" href="intro.html"/>
+<link rel="next" href="colophon.html"/>
 <script src="libs/header-attrs-2.10/header-attrs.js"></script>
 <script src="libs/jquery-3.6.0/jquery-3.6.0.min.js"></script>
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@@ -137,8 +136,12 @@ code span.wa { color: #60a0b0; font-weight: bold; font-style: italic; } /* Warni
 <li><a href="./">A New Instrument for Microbial Epidemiology</a></li>
 
 <li class="divider"></li>
-<li class="chapter" data-level="" data-path="index.html"><a href="index.html"><i class="fa fa-check"></i>Prerequisites</a></li>
-<li class="chapter" data-level="1" data-path="intro.html"><a href="intro.html"><i class="fa fa-check"></i><b>1</b> Introduction</a></li>
+<li class="chapter" data-level="" data-path="index.html"><a href="index.html"><i class="fa fa-check"></i>Preamble</a>
+<ul>
+<li class="chapter" data-level="" data-path="index.html"><a href="index.html#short-summary-250-words"><i class="fa fa-check"></i>Short summary (250 words)</a></li>
+</ul></li>
+<li class="chapter" data-level="" data-path="colophon.html"><a href="colophon.html"><i class="fa fa-check"></i>Colophon</a></li>
+<li class="chapter" data-level="1" data-path="introduction.html"><a href="introduction.html"><i class="fa fa-check"></i><b>1</b> Introduction</a></li>
 <li class="divider"></li>
 <li><a href="https://github.com/rstudio/bookdown" target="blank">Published with bookdown</a></li>
 
@@ -163,12 +166,15 @@ code span.wa { color: #60a0b0; font-weight: bold; font-style: italic; } /* Warni
 <h1 class="title">A New Instrument for Microbial Epidemiology</h1>
 <h2 class="subtitle"><em>Empowering Antimicrobial Resistance Data Analysis</em></h2>
 <p class="author"><em>Matthijs S. Berends</em></p>
-<p class="date"><em>25 August 2021</em></p>
 </div>
-<div id="prerequisites" class="section level1 unnumbered">
-<h1>Prerequisites</h1>
-<p>txt</p>
-
+<div id="preamble" class="section level1 unnumbered">
+<h1>Preamble</h1>
+<p>This is the integral PhD thesis ‘A New Instrument for Microbial Epidemiology’ (DOI <a href="https://doi.org/10.33612/diss.177417131">10.33612/diss.177417131</a>) by <a href="https://www.rug.nl/staff/m.s.berends">Matthijs S. Berends</a>, which was defended publicly at the University of Groningen, the Netherlands, on 25 August 2021.</p>
+<p>All texts were copied from the printed version ‘as is’; no modifications were made.</p>
+<div id="short-summary-250-words" class="section level3 unnumbered">
+<h3>Short summary (250 words)</h3>
+<p>Treating infectious diseases requires insights into the microorganisms causing infectious diseases. Antimicrobial resistance (AMR) in microorganisms limits treatment possibilities and poses an enormous healthcare problem worldwide. The spread and AMR patterns of microorganisms, risk factors for infection, and preventive and control measures of infectious disease are studied within the field of Microbial Epidemiology, a cross-over field between Epidemiology and Clinical Microbiology. For analysing the spread and AMR patterns of microorganisms, however, no standardised method previously existed. This thesis showcases the development and applied use of a new instrument to analyse AMR data: the AMR package for R. From multiple viewpoints, the AMR package and its advantages are put into perspective: from a technical viewpoint, from an infection management viewpoint and from a clinical viewpoint. These combined provide a common ground for comprehending what the AMR package could yield in the field and how it can set a new empowered starting point for future applications of microbial epidemiology, in clinical and research settings alike. This thesis subsequently elaborates on these multiple viewpoints by illustrating the use of this new instrument in epidemiological research projects in the Dutch-German cross-border region to better understand the occurrence and AMR patterns of microorganisms on a (eu)regional level. In conclusion, this thesis shows the added value of a consistent data-analytical instrument to prepare and analyse AMR data in a full-region approach, that can also be used in clinical settings to obtain novel insights on AMR patterns.</p>
+</div>
 </div>
             </section>
 
@@ -176,7 +182,7 @@ code span.wa { color: #60a0b0; font-weight: bold; font-style: italic; } /* Warni
         </div>
       </div>
 
-<a href="intro.html" class="navigation navigation-next navigation-unique" aria-label="Next page"><i class="fa fa-angle-right"></i></a>
+<a href="colophon.html" class="navigation navigation-next navigation-unique" aria-label="Next page"><i class="fa fa-angle-right"></i></a>
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new file mode 100644
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+<!DOCTYPE html>
+<html lang="" xml:lang="">
+<head>
+
+  <meta charset="utf-8" />
+  <meta http-equiv="X-UA-Compatible" content="IE=edge" />
+  <title>1 Introduction | A New Instrument for Microbial Epidemiology</title>
+  <meta name="description" content="This is the PhD thesis of the author." />
+  <meta name="generator" content="bookdown 0.24 and GitBook 2.6.7" />
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+  <meta property="og:title" content="1 Introduction | A New Instrument for Microbial Epidemiology" />
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+  <meta property="og:description" content="This is the PhD thesis of the author." />
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+  <div class="book without-animation with-summary font-size-2 font-family-1" data-basepath=".">
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+    <div class="book-summary">
+      <nav role="navigation">
+
+<ul class="summary">
+<li><a href="./">A New Instrument for Microbial Epidemiology</a></li>
+
+<li class="divider"></li>
+<li class="chapter" data-level="" data-path="index.html"><a href="index.html"><i class="fa fa-check"></i>Preamble</a>
+<ul>
+<li class="chapter" data-level="" data-path="index.html"><a href="index.html#short-summary-250-words"><i class="fa fa-check"></i>Short summary (250 words)</a></li>
+</ul></li>
+<li class="chapter" data-level="" data-path="colophon.html"><a href="colophon.html"><i class="fa fa-check"></i>Colophon</a></li>
+<li class="chapter" data-level="1" data-path="introduction.html"><a href="introduction.html"><i class="fa fa-check"></i><b>1</b> Introduction</a></li>
+<li class="divider"></li>
+<li><a href="https://github.com/rstudio/bookdown" target="blank">Published with bookdown</a></li>
+
+</ul>
+
+      </nav>
+    </div>
+
+    <div class="book-body">
+      <div class="body-inner">
+        <div class="book-header" role="navigation">
+          <h1>
+            <i class="fa fa-circle-o-notch fa-spin"></i><a href="./">A New Instrument for Microbial Epidemiology</a>
+          </h1>
+        </div>
+
+        <div class="page-wrapper" tabindex="-1" role="main">
+          <div class="page-inner">
+
+            <section class="normal" id="section-">
+<div id="introduction" class="section level1" number="1">
+<h1><span class="header-section-number">1</span> Introduction</h1>
+<p>You can label chapter and section titles using <code>{#label}</code> after them, e.g., we can reference Chapter <a href="introduction.html#introduction">1</a>.</p>
+<p>Figures and tables with captions will be placed in <code>figure</code> and <code>table</code> environments, respectively.</p>
+<div class="sourceCode" id="cb1"><pre class="sourceCode r"><code class="sourceCode r"><span id="cb1-1"><a href="introduction.html#cb1-1" aria-hidden="true" tabindex="-1"></a><span class="fu">par</span>(<span class="at">mar =</span> <span class="fu">c</span>(<span class="dv">4</span>, <span class="dv">4</span>, .<span class="dv">1</span>, .<span class="dv">1</span>))</span>
+<span id="cb1-2"><a href="introduction.html#cb1-2" aria-hidden="true" tabindex="-1"></a><span class="fu">plot</span>(pressure, <span class="at">type =</span> <span class="st">&#39;b&#39;</span>, <span class="at">pch =</span> <span class="dv">19</span>)</span></code></pre></div>
+<div class="figure" style="text-align: center"><span style="display:block;" id="fig:nice-fig"></span>
+<img src="a_new_instrument_for_microbial_epidemiology_files/figure-html/nice-fig-1.png" alt="Here is a nice figure!" width="80%" />
+<p class="caption">
+Figure 1.1: Here is a nice figure!
+</p>
+</div>
+<p>Reference a figure by its code chunk label with the <code>fig:</code> prefix, e.g., see Figure <a href="introduction.html#fig:nice-fig">1.1</a>. Similarly, you can reference tables generated from <code>knitr::kable()</code>, e.g., see Table <a href="introduction.html#tab:nice-tab">1.1</a>.</p>
+<div class="sourceCode" id="cb2"><pre class="sourceCode r"><code class="sourceCode r"><span id="cb2-1"><a href="introduction.html#cb2-1" aria-hidden="true" tabindex="-1"></a>knitr<span class="sc">::</span><span class="fu">kable</span>(</span>
+<span id="cb2-2"><a href="introduction.html#cb2-2" aria-hidden="true" tabindex="-1"></a>  <span class="fu">head</span>(iris, <span class="dv">20</span>), <span class="at">caption =</span> <span class="st">&#39;Here is a nice table!&#39;</span>,</span>
+<span id="cb2-3"><a href="introduction.html#cb2-3" aria-hidden="true" tabindex="-1"></a>  <span class="at">booktabs =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-4"><a href="introduction.html#cb2-4" aria-hidden="true" tabindex="-1"></a>)</span></code></pre></div>
+<table>
+<caption><span id="tab:nice-tab">Table 1.1: </span>Here is a nice table!</caption>
+<thead>
+<tr class="header">
+<th align="right">Sepal.Length</th>
+<th align="right">Sepal.Width</th>
+<th align="right">Petal.Length</th>
+<th align="right">Petal.Width</th>
+<th align="left">Species</th>
+</tr>
+</thead>
+<tbody>
+<tr class="odd">
+<td align="right">5.1</td>
+<td align="right">3.5</td>
+<td align="right">1.4</td>
+<td align="right">0.2</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="even">
+<td align="right">4.9</td>
+<td align="right">3.0</td>
+<td align="right">1.4</td>
+<td align="right">0.2</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="odd">
+<td align="right">4.7</td>
+<td align="right">3.2</td>
+<td align="right">1.3</td>
+<td align="right">0.2</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="even">
+<td align="right">4.6</td>
+<td align="right">3.1</td>
+<td align="right">1.5</td>
+<td align="right">0.2</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="odd">
+<td align="right">5.0</td>
+<td align="right">3.6</td>
+<td align="right">1.4</td>
+<td align="right">0.2</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="even">
+<td align="right">5.4</td>
+<td align="right">3.9</td>
+<td align="right">1.7</td>
+<td align="right">0.4</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="odd">
+<td align="right">4.6</td>
+<td align="right">3.4</td>
+<td align="right">1.4</td>
+<td align="right">0.3</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="even">
+<td align="right">5.0</td>
+<td align="right">3.4</td>
+<td align="right">1.5</td>
+<td align="right">0.2</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="odd">
+<td align="right">4.4</td>
+<td align="right">2.9</td>
+<td align="right">1.4</td>
+<td align="right">0.2</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="even">
+<td align="right">4.9</td>
+<td align="right">3.1</td>
+<td align="right">1.5</td>
+<td align="right">0.1</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="odd">
+<td align="right">5.4</td>
+<td align="right">3.7</td>
+<td align="right">1.5</td>
+<td align="right">0.2</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="even">
+<td align="right">4.8</td>
+<td align="right">3.4</td>
+<td align="right">1.6</td>
+<td align="right">0.2</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="odd">
+<td align="right">4.8</td>
+<td align="right">3.0</td>
+<td align="right">1.4</td>
+<td align="right">0.1</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="even">
+<td align="right">4.3</td>
+<td align="right">3.0</td>
+<td align="right">1.1</td>
+<td align="right">0.1</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="odd">
+<td align="right">5.8</td>
+<td align="right">4.0</td>
+<td align="right">1.2</td>
+<td align="right">0.2</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="even">
+<td align="right">5.7</td>
+<td align="right">4.4</td>
+<td align="right">1.5</td>
+<td align="right">0.4</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="odd">
+<td align="right">5.4</td>
+<td align="right">3.9</td>
+<td align="right">1.3</td>
+<td align="right">0.4</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="even">
+<td align="right">5.1</td>
+<td align="right">3.5</td>
+<td align="right">1.4</td>
+<td align="right">0.3</td>
+<td align="left">setosa</td>
+</tr>
+<tr class="odd">
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+<td align="right">3.8</td>
+<td align="right">1.7</td>
+<td align="right">0.3</td>
+<td align="left">setosa</td>
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+<td align="right">5.1</td>
+<td align="right">3.8</td>
+<td align="right">1.5</td>
+<td align="right">0.3</td>
+<td align="left">setosa</td>
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+
+</div>
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+
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diff --git a/docs/reference-keys.txt b/docs/reference-keys.txt
index 75c6f22..e94587b 100644
--- a/docs/reference-keys.txt
+++ b/docs/reference-keys.txt
@@ -1,3 +1,3 @@
 fig:nice-fig
 tab:nice-tab
-intro
+introduction
diff --git a/docs/search_index.json b/docs/search_index.json
index c92bd31..fc38b91 100644
--- a/docs/search_index.json
+++ b/docs/search_index.json
@@ -1 +1 @@
-[["index.html", "A New Instrument for Microbial Epidemiology Empowering Antimicrobial Resistance Data Analysis Prerequisites", " A New Instrument for Microbial Epidemiology Empowering Antimicrobial Resistance Data Analysis Matthijs S. Berends 25 August 2021 Prerequisites txt "],["intro.html", "1 Introduction", " 1 Introduction You can label chapter and section titles using {#label} after them, e.g., we can reference Chapter 1. If you do not manually label them, there will be automatic labels anyway, e.g., Chapter ??. Figures and tables with captions will be placed in figure and table environments, respectively. par(mar = c(4, 4, .1, .1)) plot(pressure, type = &#39;b&#39;, pch = 19) Figure 1.1: Here is a nice figure! Reference a figure by its code chunk label with the fig: prefix, e.g., see Figure 1.1. Similarly, you can reference tables generated from knitr::kable(), e.g., see Table 1.1. knitr::kable( head(iris, 20), caption = &#39;Here is a nice table!&#39;, booktabs = TRUE ) Table 1.1: Here is a nice table! Sepal.Length Sepal.Width Petal.Length Petal.Width Species 5.1 3.5 1.4 0.2 setosa 4.9 3.0 1.4 0.2 setosa 4.7 3.2 1.3 0.2 setosa 4.6 3.1 1.5 0.2 setosa 5.0 3.6 1.4 0.2 setosa 5.4 3.9 1.7 0.4 setosa 4.6 3.4 1.4 0.3 setosa 5.0 3.4 1.5 0.2 setosa 4.4 2.9 1.4 0.2 setosa 4.9 3.1 1.5 0.1 setosa 5.4 3.7 1.5 0.2 setosa 4.8 3.4 1.6 0.2 setosa 4.8 3.0 1.4 0.1 setosa 4.3 3.0 1.1 0.1 setosa 5.8 4.0 1.2 0.2 setosa 5.7 4.4 1.5 0.4 setosa 5.4 3.9 1.3 0.4 setosa 5.1 3.5 1.4 0.3 setosa 5.7 3.8 1.7 0.3 setosa 5.1 3.8 1.5 0.3 setosa "],["404.html", "Page not found", " Page not found The page you requested cannot be found (perhaps it was moved or renamed). You may want to try searching to find the page's new location, or use the table of contents to find the page you are looking for. "]]
+[["index.html", "A New Instrument for Microbial Epidemiology Empowering Antimicrobial Resistance Data Analysis Preamble", " A New Instrument for Microbial Epidemiology Empowering Antimicrobial Resistance Data Analysis Matthijs S. Berends Preamble This is the integral PhD thesis ‘A New Instrument for Microbial Epidemiology’ (DOI 10.33612/diss.177417131) by Matthijs S. Berends, which was defended publicly at the University of Groningen, the Netherlands, on 25 August 2021. All texts were copied from the printed version ‘as is’; no modifications were made. Short summary (250 words) Treating infectious diseases requires insights into the microorganisms causing infectious diseases. Antimicrobial resistance (AMR) in microorganisms limits treatment possibilities and poses an enormous healthcare problem worldwide. The spread and AMR patterns of microorganisms, risk factors for infection, and preventive and control measures of infectious disease are studied within the field of Microbial Epidemiology, a cross-over field between Epidemiology and Clinical Microbiology. For analysing the spread and AMR patterns of microorganisms, however, no standardised method previously existed. This thesis showcases the development and applied use of a new instrument to analyse AMR data: the AMR package for R. From multiple viewpoints, the AMR package and its advantages are put into perspective: from a technical viewpoint, from an infection management viewpoint and from a clinical viewpoint. These combined provide a common ground for comprehending what the AMR package could yield in the field and how it can set a new empowered starting point for future applications of microbial epidemiology, in clinical and research settings alike. This thesis subsequently elaborates on these multiple viewpoints by illustrating the use of this new instrument in epidemiological research projects in the Dutch-German cross-border region to better understand the occurrence and AMR patterns of microorganisms on a (eu)regional level. In conclusion, this thesis shows the added value of a consistent data-analytical instrument to prepare and analyse AMR data in a full-region approach, that can also be used in clinical settings to obtain novel insights on AMR patterns. "],["colophon.html", "Colophon", " Colophon Cover design: Matthijs Berends (images used with permission) Layout: Matthijs Berends Printing: Gildeprint – www.gildeprint.nl The work described within this thesis was supported by (1) the Certe Medical Diagnostics and Advice Foundation, (2) the INTERREG V A (202085) funded project EurHealth-1Health (http://www.eurhealth1health.eu), part of a Dutch-German cross-border network supported by the European Commission, the Dutch Ministry of Health, Welfare and Sport, the Ministry of Economy, Innovation, Digitalisation and Energy of the German Federal State of North Rhine-Westphalia, and the Ministry for National and European Affairs and Regional Development of the German Federal State of Lower Saxony, (3) the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement 713660 (MSCA-COFUND-2015-DP “Pronkjewail”), and (4) the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) through the ESCMID Study Group for Antimicrobial Stewardship (ESGAP). Printing of this thesis was financially supported by the Certe Medical Diagnostics and Advice Foundation. This support is greatly appreciated. Copyright © 2021 by Matthias Simeon Berends. All rights reserved. Any unauthorised reprint or use of this material is prohibited. No parts of this thesis may be reproduced, stored, or transmitted in any form or by any means, without written permission of the author or, when appropriate, the publishers of the publications. "],["introduction.html", "1 Introduction", " 1 Introduction You can label chapter and section titles using {#label} after them, e.g., we can reference Chapter 1. Figures and tables with captions will be placed in figure and table environments, respectively. par(mar = c(4, 4, .1, .1)) plot(pressure, type = &#39;b&#39;, pch = 19) Figure 1.1: Here is a nice figure! Reference a figure by its code chunk label with the fig: prefix, e.g., see Figure 1.1. Similarly, you can reference tables generated from knitr::kable(), e.g., see Table 1.1. knitr::kable( head(iris, 20), caption = &#39;Here is a nice table!&#39;, booktabs = TRUE ) Table 1.1: Here is a nice table! Sepal.Length Sepal.Width Petal.Length Petal.Width Species 5.1 3.5 1.4 0.2 setosa 4.9 3.0 1.4 0.2 setosa 4.7 3.2 1.3 0.2 setosa 4.6 3.1 1.5 0.2 setosa 5.0 3.6 1.4 0.2 setosa 5.4 3.9 1.7 0.4 setosa 4.6 3.4 1.4 0.3 setosa 5.0 3.4 1.5 0.2 setosa 4.4 2.9 1.4 0.2 setosa 4.9 3.1 1.5 0.1 setosa 5.4 3.7 1.5 0.2 setosa 4.8 3.4 1.6 0.2 setosa 4.8 3.0 1.4 0.1 setosa 4.3 3.0 1.1 0.1 setosa 5.8 4.0 1.2 0.2 setosa 5.7 4.4 1.5 0.4 setosa 5.4 3.9 1.3 0.4 setosa 5.1 3.5 1.4 0.3 setosa 5.7 3.8 1.7 0.3 setosa 5.1 3.8 1.5 0.3 setosa "],["404.html", "Page not found", " Page not found The page you requested cannot be found (perhaps it was moved or renamed). You may want to try searching to find the page's new location, or use the table of contents to find the page you are looking for. "]]
diff --git a/index.Rmd b/index.Rmd
index ff39d9e..3771d83 100644
--- a/index.Rmd
+++ b/index.Rmd
@@ -2,7 +2,7 @@
 title: "A New Instrument for Microbial Epidemiology"
 subtitle: "Empowering Antimicrobial Resistance Data Analysis"
 author: "Matthijs S. Berends"
-date: "25 August 2021"
+# date: "25 August 2021"
 site: bookdown::bookdown_site
 output: bookdown::gitbook
 documentclass: book
@@ -14,6 +14,24 @@ github-repo: msberends/a_new_instrument_for_microbial_epidemiology
 description: "This is the PhD thesis of the author."
 ---
 
-# Prerequisites {-}
+# Preamble {-}
 
-txt
+This is the integral PhD thesis 'A New Instrument for Microbial Epidemiology' (DOI [10.33612/diss.177417131](https://doi.org/10.33612/diss.177417131)) by [Matthijs S. Berends](https://www.rug.nl/staff/m.s.berends), which was defended publicly at the University of Groningen, the Netherlands, on 25 August 2021.
+
+All texts were copied from the printed version 'as is'; no modifications were made.
+
+### Short summary (250 words) {-}
+
+Treating infectious diseases requires insights into the microorganisms causing infectious diseases. Antimicrobial resistance (AMR) in microorganisms limits treatment possibilities and poses an enormous healthcare problem worldwide. The spread and AMR patterns of microorganisms, risk factors for infection, and preventive and control measures of infectious disease are studied within the field of Microbial Epidemiology, a cross-over field between Epidemiology and Clinical Microbiology. For analysing the spread and AMR patterns of microorganisms, however, no standardised method previously existed. This thesis showcases the development and applied use of a new instrument to analyse AMR data: the AMR package for R. From multiple viewpoints, the AMR package and its advantages are put into perspective: from a technical viewpoint, from an infection management viewpoint and from a clinical viewpoint. These combined provide a common ground for comprehending what the AMR package could yield in the field and how it can set a new empowered starting point for future applications of microbial epidemiology, in clinical and research settings alike. This thesis subsequently elaborates on these multiple viewpoints by illustrating the use of this new instrument in epidemiological research projects in the Dutch-German cross-border region to better understand the occurrence and AMR patterns of microorganisms on a (eu)regional level. In conclusion, this thesis shows the added value of a consistent data-analytical instrument to prepare and analyse AMR data in a full-region approach, that can also be used in clinical settings to obtain novel insights on AMR patterns.
+
+# Colophon {-}
+
+Cover design: Matthijs Berends (images used with permission)  
+Layout: Matthijs Berends  
+Printing: Gildeprint – www.gildeprint.nl
+
+The work described within this thesis was supported by (1) the Certe Medical Diagnostics and Advice Foundation, (2) the INTERREG V A (202085) funded project EurHealth-1Health (http://www.eurhealth1health.eu), part of a Dutch-German cross-border network supported by the European Commission, the Dutch Ministry of Health, Welfare and Sport, the Ministry of Economy, Innovation, Digitalisation and Energy of the German Federal State of North Rhine-Westphalia, and the Ministry for National and European Affairs and Regional Development of the German Federal State of Lower Saxony, (3) the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement 713660 (MSCA-COFUND-2015-DP “Pronkjewail”), and (4) the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) through the ESCMID Study Group for Antimicrobial Stewardship (ESGAP).
+
+Printing of this thesis was financially supported by the Certe Medical Diagnostics and Advice Foundation. This support is greatly appreciated.
+
+**Copyright © 2021 by Matthias Simeon Berends.** All rights reserved. Any unauthorised reprint or use of this material is prohibited. No parts of this thesis may be reproduced, stored, or transmitted in any form or by any means, without written permission of the author or, when appropriate, the publishers of the publications.