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breakpoints UTI interpretation fix
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@ -1,6 +1,6 @@
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Package: AMR
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Version: 2.0.0.9028
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Date: 2023-07-08
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Version: 2.0.0.9029
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Date: 2023-07-10
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Title: Antimicrobial Resistance Data Analysis
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Description: Functions to simplify and standardise antimicrobial resistance (AMR)
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data analysis and to work with microbial and antimicrobial properties by
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2
NEWS.md
2
NEWS.md
@ -1,4 +1,4 @@
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# AMR 2.0.0.9028
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# AMR 2.0.0.9029
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## New
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* Clinical breakpoints and intrinsic resistance of EUCAST 2023 and CLSI 2023 have been added for `as.sir()`. EUCAST 2023 (v13.0) is now the new default guideline for all MIC and disks diffusion interpretations
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@ -1241,20 +1241,20 @@ font_red_bg <- function(..., collapse = " ") {
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}
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font_orange_bg <- function(..., collapse = " ") {
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# this is #f6d55c (picked to be colourblind-safe with other SIR colours)
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try_colour(font_black(..., collapse = collapse), before = "\033[48;5;222m", after = "\033[49m", collapse = collapse)
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try_colour(font_black(..., collapse = collapse, adapt = FALSE), before = "\033[48;5;222m", after = "\033[49m", collapse = collapse)
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}
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font_yellow_bg <- function(..., collapse = " ") {
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try_colour(font_black(..., collapse = collapse), before = "\033[48;5;228m", after = "\033[49m", collapse = collapse)
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try_colour(font_black(..., collapse = collapse, adapt = FALSE), before = "\033[48;5;228m", after = "\033[49m", collapse = collapse)
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}
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font_green_bg <- function(..., collapse = " ") {
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# this is #3caea3 (picked to be colourblind-safe with other SIR colours)
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try_colour(font_black(..., collapse = collapse), before = "\033[48;5;79m", after = "\033[49m", collapse = collapse)
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try_colour(font_black(..., collapse = collapse, adapt = FALSE), before = "\033[48;5;79m", after = "\033[49m", collapse = collapse)
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}
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font_purple_bg <- function(..., collapse = " ") {
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try_colour(font_black(..., collapse = collapse), before = "\033[48;5;89m", after = "\033[49m", collapse = collapse)
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try_colour(font_black(..., collapse = collapse, adapt = FALSE), before = "\033[48;5;89m", after = "\033[49m", collapse = collapse)
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}
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font_rose_bg <- function(..., collapse = " ") {
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try_colour(font_black(..., collapse = collapse), before = "\033[48;5;217m", after = "\033[49m", collapse = collapse)
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try_colour(font_black(..., collapse = collapse, adapt = FALSE), before = "\033[48;5;217m", after = "\033[49m", collapse = collapse)
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}
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font_na <- function(..., collapse = " ") {
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font_red(..., collapse = collapse)
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2
R/data.R
2
R/data.R
@ -176,7 +176,7 @@
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#' Data Set with `r format(nrow(microorganisms.groups), big.mark = " ")` Microorganisms In Species Groups
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#'
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#' A data set containing species groups and microbiological complexes, which are used in [the clinical breakpoints table][clinial_breakpoints].
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#' A data set containing species groups and microbiological complexes, which are used in [the clinical breakpoints table][clinical_breakpoints].
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#' @format A [tibble][tibble::tibble] with `r format(nrow(microorganisms.groups), big.mark = " ")` observations and `r ncol(microorganisms.groups)` variables:
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#' - `mo_group`\cr ID of the species group / microbiological complex
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#' - `mo`\cr ID of the microorganism belonging in the species group / microbiological complex
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35
R/mo.R
35
R/mo.R
@ -134,6 +134,10 @@
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#' "Ureaplasmium urealytica",
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#' "Ureaplazma urealitycium"
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#' ))
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#'
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#' # input will get cleaned up with the input given in the `cleaning_regex` argument,
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#' # which defaults to `mo_cleaning_regex()`:
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#' cat(mo_cleaning_regex(), "\n")
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#'
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#' as.mo("Streptococcus group A")
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#'
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@ -561,14 +565,17 @@ mo_reset_session <- function() {
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#' @rdname as.mo
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#' @export
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mo_cleaning_regex <- function() {
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parts_to_remove <- c("e?spp([^a-z]+|$)", "e?ssp([^a-z]+|$)", "e?ss([^a-z]+|$)", "e?sp([^a-z]+|$)", "e?subsp", "sube?species", "e?species",
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"biovar[a-z]*", "biotype", "serovar[a-z]*", "var([^a-z]+|$)", "serogr.?up[a-z]*",
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"titer", "dummy", "Ig[ADEGM]")
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paste0(
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"(",
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"[^A-Za-z- \\(\\)\\[\\]{}]+",
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"|",
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"([({]|\\[).+([})]|\\])",
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"|",
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"(^| )(e?spp|e?ssp|e?ss|e?sp|e?subsp|sube?species|biovar|biotype|serovar|var|serogr.?up|e?species|titer|dummy)[.]*|( Ig[ADEGM])( |$))"
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)
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"|(^| )(",
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paste0(parts_to_remove[order(1 - nchar(parts_to_remove))], collapse = "|"),
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"))")
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}
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# UNDOCUMENTED METHODS ----------------------------------------------------
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@ -832,10 +839,10 @@ print.mo_uncertainties <- function(x, n = 10, ...) {
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add_MO_lookup_to_AMR_env()
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col_red <- function(x) font_rose_bg(font_black(x, collapse = NULL, adapt = FALSE), collapse = NULL)
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col_orange <- function(x) font_orange_bg(font_black(x, collapse = NULL, adapt = FALSE), collapse = NULL)
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col_yellow <- function(x) font_yellow_bg(font_black(x, collapse = NULL, adapt = FALSE), collapse = NULL)
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col_green <- function(x) font_green_bg(font_black(x, collapse = NULL, adapt = FALSE), collapse = NULL)
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col_red <- function(x) font_rose_bg(x, collapse = NULL)
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col_orange <- function(x) font_orange_bg(x, collapse = NULL)
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col_yellow <- function(x) font_yellow_bg(x, collapse = NULL)
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col_green <- function(x) font_green_bg(x, collapse = NULL)
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if (has_colour()) {
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cat(word_wrap("Colour keys: ",
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@ -978,9 +985,9 @@ convert_colloquial_input <- function(x) {
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perl = TRUE
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)
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# Streptococci in different languages, like "estreptococos grupo B"
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out[x %like_case% "strepto[ck]o[ck][a-zA-Z]* [abcdefghijkl]$"] <- gsub(".*e?strepto[ck]o[ck].* ([abcdefghijkl])$",
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out[x %like_case% "strepto[ck]o[ck][a-zA-Z ]* [abcdefghijkl]$"] <- gsub(".*e?strepto[ck]o[ck].* ([abcdefghijkl])$",
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"B_STRPT_GRP\\U\\1",
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x[x %like_case% "strepto[ck]o[ck][a-zA-Z]* [abcdefghijkl]$"],
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x[x %like_case% "strepto[ck]o[ck][a-zA-Z ]* [abcdefghijkl]$"],
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perl = TRUE
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)
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out[x %like_case% "strep[a-z]* group [abcdefghijkl]$"] <- gsub(".* ([abcdefghijkl])$",
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@ -994,6 +1001,7 @@ convert_colloquial_input <- function(x) {
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perl = TRUE
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)
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out[x %like_case% "ha?emoly.*strep"] <- "B_STRPT_HAEM"
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out[x %like_case% "(strepto.* [abcg, ]{2,4}$)"] <- "B_STRPT_ABCG"
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out[x %like_case% "(strepto.* mil+er+i|^mgs[^a-z]*$)"] <- "B_STRPT_MILL"
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out[x %like_case% "mil+er+i gr"] <- "B_STRPT_MILL"
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out[x %like_case% "((strepto|^s).* viridans|^vgs[^a-z]*$)"] <- "B_STRPT_VIRI"
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@ -1024,6 +1032,9 @@ convert_colloquial_input <- function(x) {
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out[x %like_case% "anaerob[a-z]+ .*gram[ -]?pos.*"] <- "B_ANAER-POS"
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out[is.na(out) & x %like_case% "anaerob[a-z]+ (micro)?.*organism"] <- "B_ANAER"
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# coryneform bacteria
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out[x %like_case% "^coryneform"] <- "B_CORYNF"
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# yeasts and fungi
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out[x %like_case% "^yeast?"] <- "F_YEAST"
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out[x %like_case% "^fung(us|i)"] <- "F_FUNGUS"
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@ -1032,7 +1043,11 @@ convert_colloquial_input <- function(x) {
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out[x %like_case% "meningo[ck]o[ck]"] <- "B_NESSR_MNNG"
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out[x %like_case% "gono[ck]o[ck]"] <- "B_NESSR_GNRR"
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out[x %like_case% "pneumo[ck]o[ck]"] <- "B_STRPT_PNMN"
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out[x %like_case% "hacek"] <- "B_HACEK"
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out[x %like_case% "haemophilus" & x %like_case% "aggregatibacter" & x %like_case% "cardiobacterium" & x %like_case% "eikenella" & x %like_case% "kingella"] <- "B_HACEK"
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out[x %like_case% "slow.* grow.* mycobact"] <- "B_MYCBC_SGM"
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out[x %like_case% "rapid.* grow.* mycobact"] <- "B_MYCBC_RGM"
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# unexisting names (con is the WHONET code for contamination)
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out[x %in% c("con", "other", "none", "unknown") | x %like_case% "virus"] <- "UNKNOWN"
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@ -427,22 +427,13 @@ mo_pathogenicity <- function(x, language = get_AMR_locale(), keep_synonyms = get
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kngd <- AMR_env$MO_lookup$kingdom[match(x.mo, AMR_env$MO_lookup$mo)]
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rank <- AMR_env$MO_lookup$rank[match(x.mo, AMR_env$MO_lookup$mo)]
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out <- factor(
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ifelse(prev == 1 & kngd == "Bacteria" & rank != "genus",
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"Pathogenic",
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ifelse(prev < 2 & kngd == "Fungi",
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"Potentially pathogenic",
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ifelse(prev == 2 & kngd == "Bacteria",
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"Non-pathogenic",
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ifelse(kngd == "Bacteria",
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"Potentially pathogenic",
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"Unknown"
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)
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)
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)
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),
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levels = c("Pathogenic", "Potentially pathogenic", "Non-pathogenic", "Unknown"),
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ordered = TRUE
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out <- factor(case_when_AMR(prev == 1 & kngd == "Bacteria" & rank != "genus" ~ "Pathogenic",
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(prev < 2 & kngd == "Fungi") ~ "Potentially pathogenic",
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prev == 2 & kngd == "Bacteria" ~ "Non-pathogenic",
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kngd == "Bacteria" ~ "Potentially pathogenic",
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TRUE ~ "Unknown"),
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levels = c("Pathogenic", "Potentially pathogenic", "Non-pathogenic", "Unknown"),
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ordered = TRUE
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)
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load_mo_uncertainties(metadata)
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95
R/sir.R
95
R/sir.R
@ -105,7 +105,7 @@
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#'
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#' The function [is_sir_eligible()] returns `TRUE` when a columns contains at most 5% invalid antimicrobial interpretations (not S and/or I and/or R), and `FALSE` otherwise. The threshold of 5% can be set with the `threshold` argument. If the input is a [data.frame], it iterates over all columns and returns a [logical] vector.
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#' @section Interpretation of SIR:
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#' In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (<https://www.eucast.org/newsiandr/>):
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#' In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (<https://www.eucast.org/newsiandr>):
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#'
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#' - **S - Susceptible, standard dosing regimen**\cr
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#' A microorganism is categorised as "Susceptible, standard dosing regimen", when there is a high likelihood of therapeutic success using a standard dosing regimen of the agent.
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@ -850,7 +850,7 @@ as_sir_method <- function(method_short,
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messages[i] <- word_wrap(extra_indent = 5, messages[i])
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}
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message(
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font_yellow(font_bold(paste0(" Note", ifelse(length(messages) > 1, "s", ""), ":\n"))),
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font_yellow_bg(paste0(" NOTE", ifelse(length(messages) > 1, "S", ""), " \n")),
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paste0(" ", font_black(AMR_env$bullet_icon), " ", font_black(messages, collapse = NULL), collapse = "\n")
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)
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}
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@ -873,6 +873,7 @@ as_sir_method <- function(method_short,
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# when as.sir.disk is called directly
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df$values <- as.disk(df$values)
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}
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df_unique <- unique(df[ , c("mo", "uti"), drop = FALSE])
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rise_warning <- FALSE
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rise_note <- FALSE
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@ -906,15 +907,6 @@ as_sir_method <- function(method_short,
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breakpoints <- breakpoints %pm>%
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subset(mo != "UNKNOWN" & ref_tbl %unlike% "PK.*PD")
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}
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if (all(uti == FALSE, na.rm = TRUE)) {
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# remove UTI breakpoints
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breakpoints <- breakpoints %pm>%
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subset(is.na(uti) | uti == FALSE)
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} else if (all(uti == TRUE, na.rm = TRUE)) {
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# remove UTI breakpoints
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breakpoints <- breakpoints %pm>%
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subset(uti == TRUE)
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}
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msgs <- character(0)
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if (nrow(breakpoints) == 0) {
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@ -933,32 +925,39 @@ as_sir_method <- function(method_short,
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add_intrinsic_resistance_to_AMR_env()
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}
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p <- progress_ticker(n = length(unique(df$mo)), n_min = 10, title = font_blue(intro_txt), only_bar_percent = TRUE)
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p <- progress_ticker(n = nrow(df_unique), n_min = 10, title = font_blue(intro_txt), only_bar_percent = TRUE)
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has_progress_bar <- !is.null(import_fn("progress_bar", "progress", error_on_fail = FALSE)) && nrow(df_unique) >= 10
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on.exit(close(p))
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# run the rules
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for (mo_currrent in unique(df$mo)) {
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for (i in seq_len(nrow(df_unique))) {
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p$tick()
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rows <- which(df$mo == mo_currrent)
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mo_current <- df_unique[i, "mo", drop = TRUE]
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uti_current <- df_unique[i, "uti", drop = TRUE]
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if (is.na(uti_current)) {
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# preference, so no filter on UTIs
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rows <- which(df$mo == mo_current)
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} else {
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rows <- which(df$mo == mo_current & df$uti == uti_current)
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}
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values <- df[rows, "values", drop = TRUE]
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uti <- df[rows, "uti", drop = TRUE]
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new_sir <- rep(NA_sir_, length(rows))
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# find different mo properties
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mo_current_genus <- as.mo(mo_genus(mo_currrent, language = NULL))
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mo_current_family <- as.mo(mo_family(mo_currrent, language = NULL))
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mo_current_order <- as.mo(mo_order(mo_currrent, language = NULL))
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mo_current_class <- as.mo(mo_class(mo_currrent, language = NULL))
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if (mo_currrent %in% AMR::microorganisms.groups$mo) {
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mo_current_genus <- as.mo(mo_genus(mo_current, language = NULL))
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mo_current_family <- as.mo(mo_family(mo_current, language = NULL))
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mo_current_order <- as.mo(mo_order(mo_current, language = NULL))
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mo_current_class <- as.mo(mo_class(mo_current, language = NULL))
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if (mo_current %in% AMR::microorganisms.groups$mo) {
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# get the species group
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mo_current_species_group <- AMR::microorganisms.groups$mo_group[match(mo_currrent, AMR::microorganisms.groups$mo)]
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mo_current_species_group <- AMR::microorganisms.groups$mo_group[match(mo_current, AMR::microorganisms.groups$mo)]
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} else {
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mo_current_species_group <- mo_currrent
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mo_current_species_group <- mo_current
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}
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mo_current_other <- as.mo("UNKNOWN")
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# formatted for notes
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mo_formatted <- suppressMessages(suppressWarnings(mo_fullname(mo_currrent, language = NULL, keep_synonyms = FALSE)))
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if (!mo_rank(mo_currrent) %in% c("kingdom", "phylum", "class", "order")) {
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mo_formatted <- suppressMessages(suppressWarnings(mo_fullname(mo_current, language = NULL, keep_synonyms = FALSE)))
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if (!mo_rank(mo_current) %in% c("kingdom", "phylum", "class", "order")) {
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mo_formatted <- font_italic(mo_formatted)
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}
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ab_formatted <- paste0(
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@ -976,40 +975,45 @@ as_sir_method <- function(method_short,
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mo_current_other
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))
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if (any(uti, na.rm = TRUE)) {
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if (is.na(unique(uti_current))) {
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breakpoints_current <- breakpoints_current %pm>%
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# this will put UTI = FALSE first, then UTI = TRUE, then UTI = NA
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pm_arrange(rank_index, uti) # 'uti' is a column in data set 'clinical_breakpoints'
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} else if (unique(uti_current) == TRUE) {
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breakpoints_current <- breakpoints_current %pm>%
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subset(uti == TRUE) %pm>%
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# be as specific as possible (i.e. prefer species over genus):
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# the below `pm_desc(uti)` will put `TRUE` on top and FALSE on bottom
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pm_arrange(rank_index, pm_desc(uti)) # 'uti' is a column in data set 'clinical_breakpoints'
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} else {
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pm_arrange(rank_index)
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} else if (unique(uti_current) == FALSE) {
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breakpoints_current <- breakpoints_current %pm>%
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# sort UTI = FALSE first, then UTI = TRUE
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pm_arrange(rank_index, uti)
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subset(uti == FALSE) %pm>%
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# be as specific as possible (i.e. prefer species over genus):
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pm_arrange(rank_index)
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}
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# throw notes for different body sites
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if (nrow(breakpoints_current) == 1 && all(breakpoints_current$uti == TRUE) && any(uti %in% c(FALSE, NA)) && message_not_thrown_before("as.sir", "uti", ab_coerced)) {
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site <- breakpoints_current[1L, "site", drop = FALSE] # this is the one we'll take
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if (is.na(site)) {
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site <- paste0("an unspecified body site")
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} else {
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site <- paste0("body site '", site, "'")
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}
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if (nrow(breakpoints_current) == 1 && all(breakpoints_current$uti == TRUE) && any(uti_current %in% c(FALSE, NA)) && message_not_thrown_before("as.sir", "uti", ab_coerced)) {
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# only UTI breakpoints available
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warning_("in `as.sir()`: interpretation of ", font_bold(ab_formatted), " is only available for (uncomplicated) urinary tract infections (UTI) for some microorganisms, thus assuming `uti = TRUE`. See `?as.sir`.")
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rise_warning <- TRUE
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} else if (nrow(breakpoints_current) > 1 && length(unique(breakpoints_current$site)) > 1 && any(is.na(uti)) && all(c(TRUE, FALSE) %in% breakpoints_current$uti, na.rm = TRUE) && message_not_thrown_before("as.sir", "siteUTI", mo_currrent, ab_coerced)) {
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} else if (nrow(breakpoints_current) > 1 && length(unique(breakpoints_current$site)) > 1 && any(is.na(uti_current)) && all(c(TRUE, FALSE) %in% breakpoints_current$uti, na.rm = TRUE) && message_not_thrown_before("as.sir", "siteUTI", mo_current, ab_coerced)) {
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# both UTI and Non-UTI breakpoints available
|
||||
msgs <- c(msgs, paste0("Breakpoints for UTI ", font_underline("and"), " non-UTI available for ", ab_formatted, " in ", mo_formatted, " - assuming non-UTI. Use argument `uti` to set which isolates are from urine. See `?as.sir`."))
|
||||
msgs <- c(msgs, paste0("Breakpoints for UTI ", font_underline("and"), " non-UTI available for ", ab_formatted, " in ", mo_formatted, " - assuming ", site, ". Use argument `uti` to set which isolates are from urine. See `?as.sir`."))
|
||||
breakpoints_current <- breakpoints_current %pm>%
|
||||
pm_filter(uti == FALSE)
|
||||
} else if (nrow(breakpoints_current) > 1 && length(unique(breakpoints_current$site)) > 1 && all(breakpoints_current$uti == FALSE, na.rm = TRUE) && message_not_thrown_before("as.sir", "siteOther", mo_currrent, ab_coerced)) {
|
||||
} else if (nrow(breakpoints_current) > 1 && length(unique(breakpoints_current$site)) > 1 && all(breakpoints_current$uti == FALSE, na.rm = TRUE) && message_not_thrown_before("as.sir", "siteOther", mo_current, ab_coerced)) {
|
||||
# breakpoints for multiple body sites available
|
||||
site <- breakpoints_current[1L, "site", drop = FALSE] # this is the one we'll take
|
||||
if (is.na(site)) {
|
||||
site <- paste0("an unspecified body site")
|
||||
} else {
|
||||
site <- paste0("body site '", site, "'")
|
||||
}
|
||||
msgs <- c(msgs, paste0("Multiple breakpoints available for ", ab_formatted, " in ", mo_formatted, " - assuming ", site, "."))
|
||||
}
|
||||
|
||||
# first check if mo is intrinsic resistant
|
||||
if (isTRUE(add_intrinsic_resistance) && guideline_coerced %like% "EUCAST" && paste(mo_currrent, ab_coerced) %in% AMR_env$intrinsic_resistant) {
|
||||
if (isTRUE(add_intrinsic_resistance) && guideline_coerced %like% "EUCAST" && paste(mo_current, ab_coerced) %in% AMR_env$intrinsic_resistant) {
|
||||
msgs <- c(msgs, paste0("Intrinsic resistance applied for ", ab_formatted, " in ", mo_formatted, ""))
|
||||
new_sir <- rep(as.sir("R"), length(rows))
|
||||
} else if (nrow(breakpoints_current) == 0) {
|
||||
@ -1059,10 +1063,11 @@ as_sir_method <- function(method_short,
|
||||
index = rows,
|
||||
ab_input = rep(ab.bak, length(rows)),
|
||||
ab_guideline = rep(ab_coerced, length(rows)),
|
||||
mo_input = rep(mo.bak[match(mo_currrent, df$mo)][1], length(rows)),
|
||||
mo_input = rep(mo.bak[match(mo_current, df$mo)][1], length(rows)),
|
||||
mo_guideline = rep(breakpoints_current[, "mo", drop = TRUE], length(rows)),
|
||||
guideline = rep(guideline_coerced, length(rows)),
|
||||
ref_table = rep(breakpoints_current[, "ref_tbl", drop = TRUE], length(rows)),
|
||||
uti = rep(breakpoints_current[, "uti", drop = TRUE], length(rows)),
|
||||
method = rep(method_coerced, length(rows)),
|
||||
input = as.double(values),
|
||||
outcome = as.sir(new_sir),
|
||||
@ -1078,14 +1083,14 @@ as_sir_method <- function(method_short,
|
||||
close(p)
|
||||
|
||||
# printing messages
|
||||
if (!is.null(import_fn("progress_bar", "progress", error_on_fail = FALSE))) {
|
||||
if (has_progress_bar == TRUE) {
|
||||
# the progress bar has overwritten the intro text, so:
|
||||
message_(intro_txt, appendLF = FALSE, as_note = FALSE)
|
||||
}
|
||||
if (isTRUE(rise_warning)) {
|
||||
message(font_yellow(font_bold(" * WARNING *")))
|
||||
message(font_rose_bg(" * WARNING *"))
|
||||
} else if (length(msgs) == 0) {
|
||||
message(font_green(" OK."))
|
||||
message(font_green_bg(" OK "))
|
||||
} else {
|
||||
msg_note(sort(msgs))
|
||||
}
|
||||
|
||||
@ -1 +1 @@
|
||||
87c6c20d117acd06c37bab6d93966a0b
|
||||
7aeceefb444830af010fcc16f5ba4705
|
||||
|
||||
Binary file not shown.
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Binary file not shown.
Binary file not shown.
File diff suppressed because it is too large
Load Diff
Binary file not shown.
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Binary file not shown.
@ -133,8 +133,11 @@ organisms <- organisms %>%
|
||||
select(-group) %>%
|
||||
distinct()
|
||||
|
||||
# 2023-07-08 SGM must be Slowly-growing Mycobacterium, not Strep Gamma, not sure why this went wrong
|
||||
|
||||
# 2023-07-08 SGM is also Strep gamma in WHONET, must only be Slowly-growing Mycobacterium
|
||||
organisms <- organisms %>%
|
||||
filter(!(code == "SGM" & name %like% "Streptococcus"))
|
||||
# this must be empty:
|
||||
organisms$code[organisms$code %>% duplicated()]
|
||||
|
||||
saveRDS(organisms, "data-raw/organisms.rds", version = 2)
|
||||
|
||||
@ -223,7 +226,7 @@ breakpoints %>%
|
||||
filter(!WHONET_ABX_CODE %in% whonet_antibiotics$WHONET_ABX_CODE) %>%
|
||||
pull(WHONET_ABX_CODE) %>%
|
||||
unique()
|
||||
# they are at the moment all old codes that have right replacements in `antibiotics`, so we can use as.ab()
|
||||
# they are at the moment all old codes that have the right replacements in `antibiotics`, so we can use as.ab()
|
||||
|
||||
|
||||
## Build new breakpoints table ----
|
||||
@ -260,7 +263,7 @@ breakpoints_new <- breakpoints %>%
|
||||
gsub("–", "-", ., fixed = TRUE)) %>%
|
||||
arrange(desc(guideline), mo, ab, type, method) %>%
|
||||
filter(!(is.na(breakpoint_S) & is.na(breakpoint_R)) & !is.na(mo) & !is.na(ab)) %>%
|
||||
distinct(guideline, ab, mo, method, site, breakpoint_S, .keep_all = TRUE)
|
||||
distinct(guideline, type, ab, mo, method, site, breakpoint_S, .keep_all = TRUE)
|
||||
|
||||
# check the strange duplicates
|
||||
breakpoints_new %>%
|
||||
@ -268,7 +271,7 @@ breakpoints_new %>%
|
||||
filter(id %in% .$id[which(duplicated(id))])
|
||||
# remove duplicates
|
||||
breakpoints_new <- breakpoints_new %>%
|
||||
distinct(guideline, ab, mo, method, site, .keep_all = TRUE)
|
||||
distinct(guideline, type, ab, mo, method, site, .keep_all = TRUE)
|
||||
|
||||
# fix reference table names
|
||||
breakpoints_new %>% filter(guideline %like% "EUCAST", is.na(ref_tbl)) %>% View()
|
||||
@ -289,10 +292,10 @@ breakpoints_new[which(breakpoints_new$method == "MIC" &
|
||||
breakpoints_new[which(breakpoints_new$method == "MIC" &
|
||||
is.na(breakpoints_new$breakpoint_R)), "breakpoint_R"] <- max(m)
|
||||
# raise these one higher valid MIC factor level:
|
||||
breakpoints_new[which(breakpoints_new$breakpoint_R == 129), "breakpoint_R"] <- m[which(m == 128) + 1]
|
||||
breakpoints_new[which(breakpoints_new$breakpoint_R == 257), "breakpoint_R"] <- m[which(m == 256) + 1]
|
||||
breakpoints_new[which(breakpoints_new$breakpoint_R == 513), "breakpoint_R"] <- m[which(m == 512) + 1]
|
||||
breakpoints_new[which(breakpoints_new$breakpoint_R == 1025), "breakpoint_R"] <- m[which(m == 1024) + 1]
|
||||
breakpoints_new[which(breakpoints_new$breakpoint_R == 129), "breakpoint_R"] <- 128
|
||||
breakpoints_new[which(breakpoints_new$breakpoint_R == 257), "breakpoint_R"] <- 256
|
||||
breakpoints_new[which(breakpoints_new$breakpoint_R == 513), "breakpoint_R"] <- 513
|
||||
breakpoints_new[which(breakpoints_new$breakpoint_R == 1025), "breakpoint_R"] <- 1024
|
||||
|
||||
# WHONET adds one log2 level to the R breakpoint for their software, e.g. in AMC in Enterobacterales:
|
||||
# EUCAST 2022 guideline: S <= 8 and R > 8
|
||||
@ -319,6 +322,9 @@ breakpoints_new %>% filter(guideline == "EUCAST 2023", ab == "AMC", mo == "B_[OR
|
||||
# compare with current version
|
||||
clinical_breakpoints %>% filter(guideline == "EUCAST 2022", ab == "AMC", mo == "B_[ORD]_ENTRBCTR", method == "MIC")
|
||||
|
||||
# must have "human" and "ECOFF"
|
||||
breakpoints_new %>% filter(mo == "B_STRPT_PNMN", ab == "AMP", guideline == "EUCAST 2020", method == "MIC")
|
||||
|
||||
# check dimensions
|
||||
dim(breakpoints_new)
|
||||
dim(clinical_breakpoints)
|
||||
|
||||
Binary file not shown.
@ -106,7 +106,7 @@ expect_identical(mo_oxygen_tolerance(c("Klebsiella pneumoniae", "Clostridioides
|
||||
c("aerobe", "anaerobe"))
|
||||
|
||||
expect_equal(as.character(table(mo_pathogenicity(example_isolates$mo))),
|
||||
c("1561", "422", "1", "16"))
|
||||
c("1874", "109", "1", "16"))
|
||||
|
||||
expect_equal(mo_ref("Escherichia coli"), "Castellani et al., 1919")
|
||||
expect_equal(mo_authors("Escherichia coli"), "Castellani et al.")
|
||||
@ -129,9 +129,12 @@ for (l in AMR:::LANGUAGES_SUPPORTED[-1]) {
|
||||
|
||||
# test languages
|
||||
expect_error(mo_gramstain("Escherichia coli", language = "UNKNOWN"))
|
||||
dutch <- suppressWarnings(mo_name(microorganisms$fullname[which(microorganisms$fullname %unlike% "unknown|coagulase|Fungi|[(]class[)]|[{]")], language = "nl", keep_synonyms = TRUE)) # should be transformable to English again
|
||||
expect_identical(suppressWarnings(mo_name(dutch, language = NULL, keep_synonyms = TRUE)),
|
||||
microorganisms$fullname[which(microorganisms$fullname %unlike% "unknown|coagulase|Fungi|[(]class[)]|[{]")]) # gigantic test - will run ALL names
|
||||
fullnames <- microorganisms$fullname[which(microorganisms$fullname %unlike% "unknown|coagulase|Fungi|[(]class[)]|[{]")]
|
||||
to_dutch <- suppressWarnings(mo_name(fullnames, language = "nl", keep_synonyms = TRUE))
|
||||
back_to_english <- suppressWarnings(mo_name(dutch, language = NULL, keep_synonyms = TRUE))
|
||||
diffs <- paste0('"', fullnames[fullnames != back_to_english], '"', collapse = ", ")
|
||||
expect_identical(fullnames, back_to_english, info = diffs) # gigantic test - will run ALL names
|
||||
|
||||
|
||||
# manual property function
|
||||
expect_error(mo_property("Escherichia coli", property = c("genus", "fullname")))
|
||||
|
||||
@ -201,6 +201,10 @@ as.mo(c(
|
||||
"Ureaplazma urealitycium"
|
||||
))
|
||||
|
||||
# input will get cleaned up with the input given in the `cleaning_regex` argument,
|
||||
# which defaults to `mo_cleaning_regex()`:
|
||||
cat(mo_cleaning_regex(), "\n")
|
||||
|
||||
as.mo("Streptococcus group A")
|
||||
|
||||
as.mo("S. epidermidis") # will remain species: B_STPHY_EPDR
|
||||
|
||||
@ -171,7 +171,7 @@ After using \code{\link[=as.sir]{as.sir()}}, you can use the \code{\link[=eucast
|
||||
|
||||
\subsection{Machine-Readable Clinical Breakpoints}{
|
||||
|
||||
The repository of this package \href{https://github.com/msberends/AMR/blob/main/data-raw/clinical_breakpoints.txt}{contains a machine-readable version} of all guidelines. This is a CSV file consisting of 28 454 rows and 12 columns. This file is machine-readable, since it contains one row for every unique combination of the test method (MIC or disk diffusion), the antimicrobial drug and the microorganism. \strong{This allows for easy implementation of these rules in laboratory information systems (LIS)}. Note that it only contains interpretation guidelines for humans - interpretation guidelines from CLSI for animals were removed.
|
||||
The repository of this package \href{https://github.com/msberends/AMR/blob/main/data-raw/clinical_breakpoints.txt}{contains a machine-readable version} of all guidelines. This is a CSV file consisting of 28 885 rows and 12 columns. This file is machine-readable, since it contains one row for every unique combination of the test method (MIC or disk diffusion), the antimicrobial drug and the microorganism. \strong{This allows for easy implementation of these rules in laboratory information systems (LIS)}. Note that it only contains interpretation guidelines for humans - interpretation guidelines from CLSI for animals were removed.
|
||||
}
|
||||
|
||||
\subsection{Other}{
|
||||
@ -185,7 +185,7 @@ The function \code{\link[=is_sir_eligible]{is_sir_eligible()}} returns \code{TRU
|
||||
}
|
||||
\section{Interpretation of SIR}{
|
||||
|
||||
In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (\url{https://www.eucast.org/newsiandr/}):
|
||||
In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (\url{https://www.eucast.org/newsiandr}):
|
||||
\itemize{
|
||||
\item \strong{S - Susceptible, standard dosing regimen}\cr
|
||||
A microorganism is categorised as "Susceptible, standard dosing regimen", when there is a high likelihood of therapeutic success using a standard dosing regimen of the agent.
|
||||
|
||||
@ -5,7 +5,7 @@
|
||||
\alias{clinical_breakpoints}
|
||||
\title{Data Set with Clinical Breakpoints for SIR Interpretation}
|
||||
\format{
|
||||
A \link[tibble:tibble]{tibble} with 28 454 observations and 12 variables:
|
||||
A \link[tibble:tibble]{tibble} with 28 885 observations and 12 variables:
|
||||
\itemize{
|
||||
\item \code{guideline}\cr Name of the guideline
|
||||
\item \code{type}\cr Breakpoint type, either "ECOFF", "animal", or "human"
|
||||
|
||||
@ -71,7 +71,7 @@ The function \code{\link[=count_df]{count_df()}} takes any variable from \code{d
|
||||
}
|
||||
\section{Interpretation of SIR}{
|
||||
|
||||
In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (\url{https://www.eucast.org/newsiandr/}):
|
||||
In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (\url{https://www.eucast.org/newsiandr}):
|
||||
\itemize{
|
||||
\item \strong{S - Susceptible, standard dosing regimen}\cr
|
||||
A microorganism is categorised as "Susceptible, standard dosing regimen", when there is a high likelihood of therapeutic success using a standard dosing regimen of the agent.
|
||||
|
||||
@ -174,7 +174,7 @@ Amikacin (\code{AMK}, \href{https://www.whocc.no/atc_ddd_index/?code=J01GB06&sho
|
||||
|
||||
\section{Interpretation of SIR}{
|
||||
|
||||
In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (\url{https://www.eucast.org/newsiandr/}):
|
||||
In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (\url{https://www.eucast.org/newsiandr}):
|
||||
\itemize{
|
||||
\item \strong{S - Susceptible, standard dosing regimen}\cr
|
||||
A microorganism is categorised as "Susceptible, standard dosing regimen", when there is a high likelihood of therapeutic success using a standard dosing regimen of the agent.
|
||||
|
||||
@ -17,7 +17,7 @@ A \link[tibble:tibble]{tibble} with 444 observations and 4 variables:
|
||||
microorganisms.groups
|
||||
}
|
||||
\description{
|
||||
A data set containing species groups and microbiological complexes, which are used in \link[=clinial_breakpoints]{the clinical breakpoints table}.
|
||||
A data set containing species groups and microbiological complexes, which are used in \link[=clinical_breakpoints]{the clinical breakpoints table}.
|
||||
}
|
||||
\details{
|
||||
Like all data sets in this package, this data set is publicly available for download in the following formats: R, MS Excel, Apache Feather, Apache Parquet, SPSS, SAS, and Stata. Please visit \href{https://msberends.github.io/AMR/articles/datasets.html}{our website for the download links}. The actual files are of course available on \href{https://github.com/msberends/AMR/tree/main/data-raw}{our GitHub repository}.
|
||||
|
||||
@ -146,7 +146,7 @@ Using \code{only_all_tested} has no impact when only using one antibiotic as inp
|
||||
|
||||
\section{Interpretation of SIR}{
|
||||
|
||||
In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (\url{https://www.eucast.org/newsiandr/}):
|
||||
In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (\url{https://www.eucast.org/newsiandr}):
|
||||
\itemize{
|
||||
\item \strong{S - Susceptible, standard dosing regimen}\cr
|
||||
A microorganism is categorised as "Susceptible, standard dosing regimen", when there is a high likelihood of therapeutic success using a standard dosing regimen of the agent.
|
||||
|
||||
@ -112,7 +112,7 @@ Valid options for the statistical model (argument \code{model}) are:
|
||||
}
|
||||
\section{Interpretation of SIR}{
|
||||
|
||||
In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (\url{https://www.eucast.org/newsiandr/}):
|
||||
In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) has decided to change the definitions of susceptibility testing categories S, I, and R as shown below (\url{https://www.eucast.org/newsiandr}):
|
||||
\itemize{
|
||||
\item \strong{S - Susceptible, standard dosing regimen}\cr
|
||||
A microorganism is categorised as "Susceptible, standard dosing regimen", when there is a high likelihood of therapeutic success using a standard dosing regimen of the agent.
|
||||
|
||||
Loading…
Reference in New Issue
Block a user