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(v1.4.0.9048) AmpC de-repressed cephalo-resistant mutants

This commit is contained in:
dr. M.S. (Matthijs) Berends 2020-12-27 14:23:11 +01:00
parent 8b52f9b1be
commit ed198916bf
24 changed files with 93 additions and 41 deletions
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2
.github/workflows/check.yaml vendored
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@ -120,7 +120,7 @@ jobs:
sessioninfo::session_info(pkgs, include_base = TRUE)
shell: Rscript {0}
- name: Run Check
- name: Run R CMD check
env:
_R_CHECK_CRAN_INCOMING_: false
run: rcmdcheck::rcmdcheck(args = c("--no-manual", "--as-cran"), error_on = "warning", check_dir = "check")

4
DESCRIPTION
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@ -1,5 +1,5 @@
Package: AMR
Version: 1.4.0.9047
Version: 1.4.0.9048
Date: 2020-12-27
Title: Antimicrobial Resistance Analysis
Authors@R: c(
@ -29,6 +29,8 @@ Authors@R: c(
family = "Meijer", given = c("Bart", "C."), email = "b.meijerg@certe.nl"),
person(role = "ctb",
family = "Ny", given = "Sofia", email = "sofia.ny@folkhalsomyndigheten.se"),
person(role = "ctb",
family = "Schade", given = c("Rogier", "P."), email = "r.schade@amsterdamumc.nl"),
person(role = "ctb",
family = "Souverein", given = "Dennis", email = "d.souvereing@streeklabhaarlem.nl"),
person(role = "ctb",

6
NEWS.md
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@ -1,4 +1,4 @@
# AMR 1.4.0.9047
# AMR 1.4.0.9048
## <small>Last updated: 27 December 2020</small>
### New
@ -14,6 +14,7 @@
* Functions `random_mic()`, `random_disk()` and `random_rsi()` for random number generation. They take microorganism names and antibiotic names as input to make generation more realistic.
### Changed
* New argument `ampc_cephalosporin_resistance` in `eucast_rules()` to correct for AmpC de-repressed cephalosporin-resistant mutants
* Interpretation of antimicrobial resistance - `as.rsi()`:
* Reference data used for `as.rsi()` can now be set by the user, using the `reference_data` argument. This allows for using own interpretation guidelines. The user-set data must have the same structure as `rsi_translation`.
* Better determination of disk zones and MIC values when running `as.rsi()` on a data.frame
@ -50,7 +51,8 @@
### Other
* All messages and warnings thrown by this package now break sentences on whole words
* More extensive unit tests
* Internal calls to `options()` were all removed in favour of a new internal environment `mo_env`
* Internal calls to `options()` were all removed in favour of a new internal environment `pkg_env`
* Added Dr. Rogier Schade as contributor
# AMR 1.4.0

2
R/episode.R
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@ -50,7 +50,7 @@
#' get_episode(example_isolates$date, episode_days = 60)
#' is_new_episode(example_isolates$date, episode_days = 60)
#'
#' # filter on results from the third 60-day episode using base R
#' # filter on results from the third 60-day episode only, using base R
#' example_isolates[which(get_episode(example_isolates$date, 60) == 3), ]
#'
#' \donttest{

19
R/eucast_rules.R
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@ -64,6 +64,7 @@ format_eucast_version_nr <- function(version, markdown = TRUE) {
#' @param verbose a [logical] to turn Verbose mode on and off (default is off). In Verbose mode, the function does not apply rules to the data, but instead returns a data set in logbook form with extensive info about which rows and columns would be effected and in which way. Using Verbose mode takes a lot more time.
#' @param version_breakpoints the version number to use for the EUCAST Clinical Breakpoints guideline. Currently supported: `r paste0(names(EUCAST_VERSION_BREAKPOINTS), collapse = ", ")`.
#' @param version_expertrules the version number to use for the EUCAST Expert Rules and Intrinsic Resistance guideline. Currently supported: `r paste0(names(EUCAST_VERSION_EXPERT_RULES), collapse = ", ")`.
#' @param ampc_cephalosporin_resistance a character value that should be applied for AmpC de-repressed cephalosporin-resistant mutants, defaults to `NA`. Currently only works when `version_expertrules` is `3.2`; '*EUCAST Expert Rules v3.2 on Enterobacterales*' states that susceptible (S) results of cefotaxime, ceftriaxone and ceftazidime should be reported with a note, or results should be suppressed (emptied) for these agents. A value of `NA` for this argument will remove results for these agents, while e.g. a value of `"R"` will make the results for these agents resistant. Use `NULL` to not alter the results for AmpC de-repressed cephalosporin-resistant mutants. \cr For *EUCAST Expert Rules* v3.2, this rule applies to: *`r gsub("|", "*, *", gsub("[)(^)]", "", eucast_rules_file[which(eucast_rules_file$reference.version == 3.2 & eucast_rules_file$reference.rule %like% "ampc"), "this_value"][1]), fixed = TRUE)`*.
#' @param ... column name of an antibiotic, please see section *Antibiotics* below
#' @inheritParams first_isolate
#' @details
@ -149,6 +150,7 @@ eucast_rules <- function(x,
verbose = FALSE,
version_breakpoints = 10.0,
version_expertrules = 3.2,
ampc_cephalosporin_resistance = NA,
...) {
meet_criteria(x, allow_class = "data.frame")
meet_criteria(col_mo, allow_class = "character", has_length = 1, is_in = colnames(x), allow_NULL = TRUE)
@ -157,6 +159,7 @@ eucast_rules <- function(x,
meet_criteria(verbose, allow_class = "logical", has_length = 1)
meet_criteria(version_breakpoints, allow_class = "numeric", has_length = 1)
meet_criteria(version_expertrules, allow_class = "numeric", has_length = 1)
meet_criteria(ampc_cephalosporin_resistance, allow_class = c("rsi", "character"), has_length = 1, allow_NA = TRUE, allow_NULL = TRUE, is_in = c("R", "S", "I"))
x_deparsed <- deparse(substitute(x))
if (length(x_deparsed) > 1 || !all(x_deparsed %like% "[a-z]+")) {
@ -731,7 +734,7 @@ eucast_rules <- function(x,
# Official EUCAST rules ---------------------------------------------------
eucast_notification_shown <- FALSE
if (!is.null(list(...)$eucast_rules_df)) {
# this allows: eucast_rules(x, eucast_rules_df = AMR:::eucast_rules_file %pm>% filter(is.na(have_these_values)))
# this allows: eucast_rules(x, eucast_rules_df = AMR:::eucast_rules_file %>% filter(is.na(have_these_values)))
eucast_rules_df <- list(...)$eucast_rules_df
} else {
# otherwise internal data file, created in data-raw/internals.R
@ -749,6 +752,13 @@ eucast_rules <- function(x,
!reference.rule_group %like% "expert" |
(reference.rule_group %like% "expert" & reference.version == version_expertrules))
}
# filter out AmpC de-repressed cephalosporin-resistant mutants ----
if (is.null(ampc_cephalosporin_resistance)) {
eucast_rules_df <- subset(eucast_rules_df,
!reference.rule %like% "ampc")
} else {
eucast_rules_df[which(eucast_rules_df$reference.rule %like% "ampc"), "to_value"] <- as.character(ampc_cephalosporin_resistance)
}
for (i in seq_len(nrow(eucast_rules_df))) {
@ -946,7 +956,7 @@ eucast_rules <- function(x,
by = c(".rowid" = "rowid")) %pm>%
pm_select(-`.rowid`) %pm>%
pm_select(row, pm_everything()) %pm>%
pm_filter(!is.na(new)) %pm>%
pm_filter(!is.na(new) | is.na(new) & !is.na(old)) %pm>%
pm_arrange(row, rule_group, rule_name, col)
rownames(verbose_info) <- NULL
}
@ -1007,6 +1017,7 @@ eucast_rules <- function(x,
if (total_n_changed > 0) {
changed_summary <- verbose_info %pm>%
pm_filter(!is.na(old)) %pm>%
pm_mutate(new = ifelse(is.na(new), "NA", new)) %pm>%
pm_count(old, new, name = "n")
cat(paste(" -",
paste0(formatnr(changed_summary$n), " test result", ifelse(changed_summary$n > 1, "s", ""), " changed from ",
@ -1092,7 +1103,7 @@ edit_rsi <- function(x,
if (w$message %like% "invalid factor level") {
xyz <- sapply(cols, function(col) {
new_edits[, col] <<- factor(x = as.character(pm_pull(new_edits, col)),
levels = unique(c(to, levels(pm_pull(new_edits, col)))))
levels = unique(c(to, levels(pm_pull(new_edits, col)))))
invisible()
})
suppressWarnings(new_edits[rows, cols] <<- to)
@ -1134,7 +1145,7 @@ edit_rsi <- function(x,
stringsAsFactors = FALSE)
colnames(verbose_new) <- c("rowid", "col", "mo_fullname", "old", "new",
"rule", "rule_group", "rule_name", "rule_source")
verbose_new <- verbose_new %pm>% pm_filter(old != new | is.na(old))
verbose_new <- verbose_new %pm>% pm_filter(old != new | is.na(old) | is.na(new) & !is.na(old))
# save changes to data set 'verbose_info'
track_changes$verbose_info <- rbind(track_changes$verbose_info,
verbose_new,

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R/sysdata.rda
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2
cran-comments.md
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@ -1,3 +1 @@
* Edited the unit tests, so they will run under 10 minutes on CRAN (using testthat::skip_on_cran() on some tests).
* Since version 0.3.0 (2018-08-14), CHECK returns a NOTE for having a data directory over 3 MB. This is needed to offer users reference data for the complete taxonomy of microorganisms - one of the most important features of this package.

3
data-raw/eucast_rules.tsv
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@ -300,3 +300,6 @@ genus_species is Moraxella catarrhalis NAL S fluoroquinolones S Expert Rules on
genus_species is Moraxella catarrhalis NAL R fluoroquinolones R Expert Rules on Moraxella catarrhalis Expert Rules 3.2
genus is Campylobacter ERY S CLR, AZM S Expert Rules on Campylobacter Expert Rules 3.2
genus_species is Campylobacter ERY R CLR, AZM R Expert Rules on Campylobacter Expert Rules 3.2
fullname like ^(Enterobacter|Klebsiella aerogenes|Citrobacter freundii|Hafnia alvei|Serratia|Morganella morganii|Providencia) CTX S CTX, CRO, CAZ Expert Rules on Enterobacterales (AmpC de-repressed cephalosporins) Expert Rules 3.2 This is rule 3 and 4 of EUCAST Expert Rules v3.2 on Enterobacterales, result will be set with the 'ampc_derepressed_cephalosporins' argument
fullname like ^(Enterobacter|Klebsiella aerogenes|Citrobacter freundii|Hafnia alvei|Serratia|Morganella morganii|Providencia) CRO S CTX, CRO, CAZ Expert Rules on Enterobacterales (AmpC de-repressed cephalosporins) Expert Rules 3.2 This is rule 3 and 4 of EUCAST Expert Rules v3.2 on Enterobacterales, result will be set with the 'ampc_derepressed_cephalosporins' argument
fullname like ^(Enterobacter|Klebsiella aerogenes|Citrobacter freundii|Hafnia alvei|Serratia|Morganella morganii|Providencia) CAZ S CTX, CRO, CAZ Expert Rules on Enterobacterales (AmpC de-repressed cephalosporins) Expert Rules 3.2 This is rule 3 and 4 of EUCAST Expert Rules v3.2 on Enterobacterales, result will be set with the 'ampc_derepressed_cephalosporins' argument

Can't render this file because it contains an unexpected character in line 6 and column 96.

2
docs/404.html
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@ -81,7 +81,7 @@
</button>
<span class="navbar-brand">
<a class="navbar-link" href="https://msberends.github.io/AMR//index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9047</span>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9048</span>
</span>
</div>

2
docs/LICENSE-text.html
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@ -81,7 +81,7 @@
</button>
<span class="navbar-brand">
<a class="navbar-link" href="index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9047</span>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9048</span>
</span>
</div>

2
docs/articles/index.html
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@ -81,7 +81,7 @@
</button>
<span class="navbar-brand">
<a class="navbar-link" href="../index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9047</span>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9048</span>
</span>
</div>

6
docs/authors.html
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@ -81,7 +81,7 @@
</button>
<span class="navbar-brand">
<a class="navbar-link" href="index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9047</span>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9048</span>
</span>
</div>
@ -303,6 +303,10 @@
<p><strong>Sofia Ny</strong>. Contributor.
</p>
</li>
<li>
<p><strong>Rogier P. Schade</strong>. Contributor.
</p>
</li>
<li>
<p><strong>Dennis Souverein</strong>. Contributor.
</p>

1
docs/extra.js
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@ -90,6 +90,7 @@ $(document).ready(function() {
x = x.replace("Judith", "Dr. Judith");
x = x.replace("Gwen", "Dr. Gwen");
x = x.replace("Anthony", "Dr. Anthony");
x = x.replace("Rogier", "Dr. Rogier");
}
return(x);
}

2
docs/index.html
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@ -43,7 +43,7 @@
</button>
<span class="navbar-brand">
<a class="navbar-link" href="index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9047</span>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9048</span>
</span>
</div>

12
docs/news/index.html
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@ -81,7 +81,7 @@
</button>
<span class="navbar-brand">
<a class="navbar-link" href="../index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9047</span>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9048</span>
</span>
</div>
@ -236,9 +236,9 @@
<small>Source: <a href='https://github.com/msberends/AMR/blob/master/NEWS.md'><code>NEWS.md</code></a></small>
</div>
<div id="amr-1409047" class="section level1">
<h1 class="page-header" data-toc-text="1.4.0.9047">
<a href="#amr-1409047" class="anchor"></a>AMR 1.4.0.9047<small> Unreleased </small>
<div id="amr-1409048" class="section level1">
<h1 class="page-header" data-toc-text="1.4.0.9048">
<a href="#amr-1409048" class="anchor"></a>AMR 1.4.0.9048<small> Unreleased </small>
</h1>
<div id="last-updated-27-december-2020" class="section level2">
<h2 class="hasAnchor">
@ -266,6 +266,7 @@
<h3 class="hasAnchor">
<a href="#changed" class="anchor"></a>Changed</h3>
<ul>
<li><p>New argument <code>ampc_cephalosporin_resistance</code> in <code><a href="../reference/eucast_rules.html">eucast_rules()</a></code> to correct for AmpC de-repressed cephalosporin-resistant mutants</p></li>
<li>
<p>Interpretation of antimicrobial resistance - <code><a href="../reference/as.rsi.html">as.rsi()</a></code>:</p>
<ul>
@ -313,8 +314,9 @@
<ul>
<li>All messages and warnings thrown by this package now break sentences on whole words</li>
<li>More extensive unit tests</li>
<li>Internal calls to <code><a href="https://rdrr.io/r/base/options.html">options()</a></code> were all removed in favour of a new internal environment <code>mo_env</code>
<li>Internal calls to <code><a href="https://rdrr.io/r/base/options.html">options()</a></code> were all removed in favour of a new internal environment <code>pkg_env</code>
</li>
<li>Added Dr. Rogier Schade as contributor</li>
</ul>
</div>
</div>

2
docs/pkgdown.yml
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@ -12,7 +12,7 @@ articles:
datasets: datasets.html
resistance_predict: resistance_predict.html
welcome_to_AMR: welcome_to_AMR.html
last_built: 2020-12-26T23:29Z
last_built: 2020-12-27T13:22Z
urls:
reference: https://msberends.github.io/AMR//reference
article: https://msberends.github.io/AMR//articles

7
docs/reference/eucast_rules.html
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@ -83,7 +83,7 @@ To improve the interpretation of the antibiogram before EUCAST rules are applied
</button>
<span class="navbar-brand">
<a class="navbar-link" href="../index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9046</span>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9048</span>
</span>
</div>
@ -252,6 +252,7 @@ To improve the interpretation of the antibiogram before EUCAST rules are applied
verbose <span class='op'>=</span> <span class='cn'>FALSE</span>,
version_breakpoints <span class='op'>=</span> <span class='fl'>10</span>,
version_expertrules <span class='op'>=</span> <span class='fl'>3.2</span>,
ampc_cephalosporin_resistance <span class='op'>=</span> <span class='cn'>NA</span>,
<span class='va'>...</span>
<span class='op'>)</span></pre>
@ -286,6 +287,10 @@ To improve the interpretation of the antibiogram before EUCAST rules are applied
<th>version_expertrules</th>
<td><p>the version number to use for the EUCAST Expert Rules and Intrinsic Resistance guideline. Currently supported: 3.1, 3.2.</p></td>
</tr>
<tr>
<th>ampc_cephalosporin_resistance</th>
<td><p>a character value that should be applied for AmpC de-repressed cephalosporin-resistant mutants, defaults to <code>NA</code>. Currently only works when <code>version_expertrules</code> is <code>3.2</code>; '<em>EUCAST Expert Rules v3.2 on Enterobacterales</em>' states that susceptible (S) results of cefotaxime, ceftriaxone and ceftazidime should be reported with a note, or results should be suppressed (emptied) for these agents. A value of <code>NA</code> for this argument will remove results for these agents, while e.g. a value of <code>"R"</code> will make the results for these agents resistant. Use <code>NULL</code> to not alter the results for AmpC de-repressed cephalosporin-resistant mutants. <br /> For <em>EUCAST Expert Rules</em> v3.2, this rule applies to: <em>Enterobacter</em>, <em>Klebsiella aerogenes</em>, <em>Citrobacter freundii</em>, <em>Hafnia alvei</em>, <em>Serratia</em>, <em>Morganella morganii</em>, <em>Providencia</em>.</p></td>
</tr>
<tr>
<th>...</th>
<td><p>column name of an antibiotic, please see section <em>Antibiotics</em> below</p></td>

30
docs/reference/get_episode.html
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@ -82,7 +82,7 @@
</button>
<span class="navbar-brand">
<a class="navbar-link" href="../index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9046</span>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9048</span>
</span>
</div>
@ -275,7 +275,7 @@
<p>Dates are first sorted from old to new. The oldest date will mark the start of the first episode. After this date, the next date will be marked that is at least <code>episode_days</code> days later than the start of the first episode. From that second marked date on, the next date will be marked that is at least <code>episode_days</code> days later than the start of the second episode which will be the start of the third episode, and so on. Before the vector is being returned, the original order will be restored.</p>
<p>The <code><a href='first_isolate.html'>first_isolate()</a></code> function is a wrapper around the <code>is_new_episode()</code> function, but is more efficient for data sets containing microorganism codes or names.</p>
<p>The <code>dplyr</code> package is not required for these functions to work, but these functions support <a href='https://rdrr.io/pkg/dplyr/man/group_by.html'>variable grouping</a> and work conveniently inside <code>dplyr</code> verbs such as <code><a href='https://rdrr.io/pkg/dplyr/man/filter.html'>filter()</a></code>, <code><a href='https://rdrr.io/pkg/dplyr/man/mutate.html'>mutate()</a></code> and <code><a href='https://rdrr.io/pkg/dplyr/man/summarise.html'>summarise()</a></code>.</p>
<p>The <code>dplyr</code> package is not required for these functions to work, but these functions support <a href='https://dplyr.tidyverse.org/reference/group_by.html'>variable grouping</a> and work conveniently inside <code>dplyr</code> verbs such as <code><a href='https://dplyr.tidyverse.org/reference/filter.html'>filter()</a></code>, <code><a href='https://dplyr.tidyverse.org/reference/mutate.html'>mutate()</a></code> and <code><a href='https://dplyr.tidyverse.org/reference/summarise.html'>summarise()</a></code>.</p>
<h2 class="hasAnchor" id="stable-lifecycle"><a class="anchor" href="#stable-lifecycle"></a>Stable lifecycle</h2>
@ -299,7 +299,7 @@ The <a href='lifecycle.html'>lifecycle</a> of this function is <strong>stable</s
<span class='fu'>get_episode</span><span class='op'>(</span><span class='va'>example_isolates</span><span class='op'>$</span><span class='va'>date</span>, episode_days <span class='op'>=</span> <span class='fl'>60</span><span class='op'>)</span>
<span class='fu'>is_new_episode</span><span class='op'>(</span><span class='va'>example_isolates</span><span class='op'>$</span><span class='va'>date</span>, episode_days <span class='op'>=</span> <span class='fl'>60</span><span class='op'>)</span>
<span class='co'># filter on results from the third 60-day episode using base R</span>
<span class='co'># filter on results from the third 60-day episode only, using base R</span>
<span class='va'>example_isolates</span><span class='op'>[</span><span class='fu'><a href='https://rdrr.io/r/base/which.html'>which</a></span><span class='op'>(</span><span class='fu'>get_episode</span><span class='op'>(</span><span class='va'>example_isolates</span><span class='op'>$</span><span class='va'>date</span>, <span class='fl'>60</span><span class='op'>)</span> <span class='op'>==</span> <span class='fl'>3</span><span class='op'>)</span>, <span class='op'>]</span>
<span class='co'># \donttest{</span>
@ -307,23 +307,23 @@ The <a href='lifecycle.html'>lifecycle</a> of this function is <strong>stable</s
<span class='co'># is_new_episode() can also be used in dplyr verbs to determine patient</span>
<span class='co'># episodes based on any (combination of) grouping variables:</span>
<span class='va'>example_isolates</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/mutate.html'>mutate</a></span><span class='op'>(</span>condition <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/sample.html'>sample</a></span><span class='op'>(</span>x <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"A"</span>, <span class='st'>"B"</span>, <span class='st'>"C"</span><span class='op'>)</span>,
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/mutate.html'>mutate</a></span><span class='op'>(</span>condition <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/sample.html'>sample</a></span><span class='op'>(</span>x <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"A"</span>, <span class='st'>"B"</span>, <span class='st'>"C"</span><span class='op'>)</span>,
size <span class='op'>=</span> <span class='fl'>2000</span>,
replace <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span><span class='op'>)</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/group_by.html'>group_by</a></span><span class='op'>(</span><span class='va'>condition</span><span class='op'>)</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/mutate.html'>mutate</a></span><span class='op'>(</span>new_episode <span class='op'>=</span> <span class='fu'>is_new_episode</span><span class='op'>(</span><span class='va'>date</span>, <span class='fl'>365</span><span class='op'>)</span><span class='op'>)</span>
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span><span class='op'>(</span><span class='va'>condition</span><span class='op'>)</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/mutate.html'>mutate</a></span><span class='op'>(</span>new_episode <span class='op'>=</span> <span class='fu'>is_new_episode</span><span class='op'>(</span><span class='va'>date</span>, <span class='fl'>365</span><span class='op'>)</span><span class='op'>)</span>
<span class='va'>example_isolates</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/group_by.html'>group_by</a></span><span class='op'>(</span><span class='va'>hospital_id</span>, <span class='va'>patient_id</span><span class='op'>)</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/mutate.html'>transmute</a></span><span class='op'>(</span><span class='va'>date</span>,
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span><span class='op'>(</span><span class='va'>hospital_id</span>, <span class='va'>patient_id</span><span class='op'>)</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/mutate.html'>transmute</a></span><span class='op'>(</span><span class='va'>date</span>,
<span class='va'>patient_id</span>,
new_index <span class='op'>=</span> <span class='fu'>get_episode</span><span class='op'>(</span><span class='va'>date</span>, <span class='fl'>60</span><span class='op'>)</span>,
new_logical <span class='op'>=</span> <span class='fu'>is_new_episode</span><span class='op'>(</span><span class='va'>date</span>, <span class='fl'>60</span><span class='op'>)</span><span class='op'>)</span>
<span class='va'>example_isolates</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/group_by.html'>group_by</a></span><span class='op'>(</span><span class='va'>hospital_id</span><span class='op'>)</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/summarise.html'>summarise</a></span><span class='op'>(</span>patients <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/n_distinct.html'>n_distinct</a></span><span class='op'>(</span><span class='va'>patient_id</span><span class='op'>)</span>,
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span><span class='op'>(</span><span class='va'>hospital_id</span><span class='op'>)</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/summarise.html'>summarise</a></span><span class='op'>(</span>patients <span class='op'>=</span> <span class='fu'><a href='https://dplyr.tidyverse.org/reference/n_distinct.html'>n_distinct</a></span><span class='op'>(</span><span class='va'>patient_id</span><span class='op'>)</span>,
n_episodes_365 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/sum.html'>sum</a></span><span class='op'>(</span><span class='fu'>is_new_episode</span><span class='op'>(</span><span class='va'>date</span>, episode_days <span class='op'>=</span> <span class='fl'>365</span><span class='op'>)</span><span class='op'>)</span>,
n_episodes_60 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/sum.html'>sum</a></span><span class='op'>(</span><span class='fu'>is_new_episode</span><span class='op'>(</span><span class='va'>date</span>, episode_days <span class='op'>=</span> <span class='fl'>60</span><span class='op'>)</span><span class='op'>)</span>,
n_episodes_30 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/sum.html'>sum</a></span><span class='op'>(</span><span class='fu'>is_new_episode</span><span class='op'>(</span><span class='va'>date</span>, episode_days <span class='op'>=</span> <span class='fl'>30</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span>
@ -332,19 +332,19 @@ The <a href='lifecycle.html'>lifecycle</a> of this function is <strong>stable</s
<span class='co'># grouping on patients and microorganisms leads to the same results</span>
<span class='co'># as first_isolate():</span>
<span class='va'>x</span> <span class='op'>&lt;-</span> <span class='va'>example_isolates</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/filter.html'>filter</a></span><span class='op'>(</span><span class='fu'><a href='first_isolate.html'>first_isolate</a></span><span class='op'>(</span><span class='va'>.</span>, include_unknown <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span><span class='op'>)</span>
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/filter.html'>filter</a></span><span class='op'>(</span><span class='fu'><a href='first_isolate.html'>first_isolate</a></span><span class='op'>(</span><span class='va'>.</span>, include_unknown <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span><span class='op'>)</span>
<span class='va'>y</span> <span class='op'>&lt;-</span> <span class='va'>example_isolates</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/group_by.html'>group_by</a></span><span class='op'>(</span><span class='va'>patient_id</span>, <span class='va'>mo</span><span class='op'>)</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/filter.html'>filter</a></span><span class='op'>(</span><span class='fu'>is_new_episode</span><span class='op'>(</span><span class='va'>date</span>, <span class='fl'>365</span><span class='op'>)</span><span class='op'>)</span>
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span><span class='op'>(</span><span class='va'>patient_id</span>, <span class='va'>mo</span><span class='op'>)</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/filter.html'>filter</a></span><span class='op'>(</span><span class='fu'>is_new_episode</span><span class='op'>(</span><span class='va'>date</span>, <span class='fl'>365</span><span class='op'>)</span><span class='op'>)</span>
<span class='fu'><a href='https://rdrr.io/r/base/identical.html'>identical</a></span><span class='op'>(</span><span class='va'>x</span><span class='op'>$</span><span class='va'>patient_id</span>, <span class='va'>y</span><span class='op'>$</span><span class='va'>patient_id</span><span class='op'>)</span>
<span class='co'># but is_new_episode() has a lot more flexibility than first_isolate(),</span>
<span class='co'># since you can now group on anything that seems relevant:</span>
<span class='va'>example_isolates</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/group_by.html'>group_by</a></span><span class='op'>(</span><span class='va'>patient_id</span>, <span class='va'>mo</span>, <span class='va'>hospital_id</span>, <span class='va'>ward_icu</span><span class='op'>)</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://rdrr.io/pkg/dplyr/man/mutate.html'>mutate</a></span><span class='op'>(</span>flag_episode <span class='op'>=</span> <span class='fu'>is_new_episode</span><span class='op'>(</span><span class='va'>date</span>, <span class='fl'>365</span><span class='op'>)</span><span class='op'>)</span>
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/group_by.html'>group_by</a></span><span class='op'>(</span><span class='va'>patient_id</span>, <span class='va'>mo</span>, <span class='va'>hospital_id</span>, <span class='va'>ward_icu</span><span class='op'>)</span> <span class='op'>%&gt;%</span>
<span class='fu'><a href='https://dplyr.tidyverse.org/reference/mutate.html'>mutate</a></span><span class='op'>(</span>flag_episode <span class='op'>=</span> <span class='fu'>is_new_episode</span><span class='op'>(</span><span class='va'>date</span>, <span class='fl'>365</span><span class='op'>)</span><span class='op'>)</span>
<span class='op'>}</span>
<span class='co'># }</span>
</pre>

2
docs/reference/index.html
View File

@ -81,7 +81,7 @@
</button>
<span class="navbar-brand">
<a class="navbar-link" href="../index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9047</span>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9048</span>
</span>
</div>

2
docs/survey.html
View File

@ -81,7 +81,7 @@
</button>
<span class="navbar-brand">
<a class="navbar-link" href="index.html">AMR (for R)</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9047</span>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Latest development version">1.4.0.9048</span>
</span>
</div>

3
man/eucast_rules.Rd
View File

@ -23,6 +23,7 @@ eucast_rules(
verbose = FALSE,
version_breakpoints = 10,
version_expertrules = 3.2,
ampc_cephalosporin_resistance = NA,
...
)
}
@ -41,6 +42,8 @@ eucast_rules(
\item{version_expertrules}{the version number to use for the EUCAST Expert Rules and Intrinsic Resistance guideline. Currently supported: 3.1, 3.2.}
\item{ampc_cephalosporin_resistance}{a character value that should be applied for AmpC de-repressed cephalosporin-resistant mutants, defaults to \code{NA}. Currently only works when \code{version_expertrules} is \code{3.2}; '\emph{EUCAST Expert Rules v3.2 on Enterobacterales}' states that susceptible (S) results of cefotaxime, ceftriaxone and ceftazidime should be reported with a note, or results should be suppressed (emptied) for these agents. A value of \code{NA} for this argument will remove results for these agents, while e.g. a value of \code{"R"} will make the results for these agents resistant. Use \code{NULL} to not alter the results for AmpC de-repressed cephalosporin-resistant mutants. \cr For \emph{EUCAST Expert Rules} v3.2, this rule applies to: \emph{Enterobacter}, \emph{Klebsiella aerogenes}, \emph{Citrobacter freundii}, \emph{Hafnia alvei}, \emph{Serratia}, \emph{Morganella morganii}, \emph{Providencia}.}
\item{...}{column name of an antibiotic, please see section \emph{Antibiotics} below}
}
\value{

2
man/get_episode.Rd
View File

@ -52,7 +52,7 @@ On our website \url{https://msberends.github.io/AMR/} you can find \href{https:/
get_episode(example_isolates$date, episode_days = 60)
is_new_episode(example_isolates$date, episode_days = 60)
# filter on results from the third 60-day episode using base R
# filter on results from the third 60-day episode only, using base R
example_isolates[which(get_episode(example_isolates$date, 60) == 3), ]
\donttest{

1
pkgdown/extra.js
View File

@ -90,6 +90,7 @@ $(document).ready(function() {
x = x.replace("Judith", "Dr. Judith");
x = x.replace("Gwen", "Dr. Gwen");
x = x.replace("Anthony", "Dr. Anthony");
x = x.replace("Rogier", "Dr. Rogier");
}
return(x);
}

20
tests/testthat/test-eucast_rules.R
View File

@ -118,4 +118,24 @@ test_that("EUCAST rules work", {
# check verbose output
expect_output(suppressWarnings(eucast_rules(example_isolates, verbose = TRUE, rules = "all", info = TRUE)))
# AmpC de-repressed cephalo mutants
expect_identical(
eucast_rules(data.frame(mo = c("Escherichia coli", "Enterobacter cloacae"),
cefotax = as.rsi(c("S", "S"))),
ampc_derepressed_cephalosporins = "R",
info = FALSE)$cefotax,
as.rsi(c("S", "R")))
expect_identical(
eucast_rules(data.frame(mo = c("Escherichia coli", "Enterobacter cloacae"),
cefotax = as.rsi(c("S", "S"))),
ampc_derepressed_cephalosporins = NA,
info = FALSE)$cefotax,
as.rsi(c("S", NA)))
expect_identical(
eucast_rules(data.frame(mo = c("Escherichia coli", "Enterobacter cloacae"),
cefotax = as.rsi(c("S", "S"))),
ampc_derepressed_cephalosporins = NULL,
info = FALSE)$cefotax,
as.rsi(c("S", "S")))
})