v2.1.1

.Rbuildignore

@@ -33,7 +33,6 @@
 ^vignettes/other_pkg.*\.Rmd$
 ^vignettes/PCA\.Rmd$
 ^vignettes/resistance_predict\.Rmd$
-^vignettes/SPSS\.Rmd$
 ^vignettes/WHONET\.Rmd$
 ^logo.svg$
 ^CRAN-SUBMISSION$

.github/prehooks/pre-commit

@@ -69,16 +69,10 @@ if [ "$currenttag" = "" ]; then
 else
   # there is a tag, so base version number on that
   currentcommit=$(git rev-list --count ${currenttagfull}..${defaultbranch})
-  if (( "$currentcommit" == 0 )); then
-    # tag is new, so this must become the version number
-    currentversion="$currenttag"
-  fi
   echo "- latest tag is '${currenttagfull}', with ${currentcommit} previous commits in '${defaultbranch}'"
 fi
-if [ "$currentversion" = "" ]; then
-  # combine tag (e.g. 1.2.3) and commit number (like 5) increased by 9000 to indicate beta version
-  currentversion="$currenttag.$((currentcommit + 9001))" # results in e.g. 1.2.3.9005
-fi
+# combine tag (e.g. 1.2.3) and commit number (like 5) increased by 9000 to indicate beta version
+currentversion="$currenttag.$((currentcommit + 9001))" # results in e.g. 1.2.3.9005
 echo "- ${currentpkg} pkg version set to ${currentversion}"
 
 # set version number and date to DESCRIPTION file

CRAN-SUBMISSION

@@ -1,3 +1,3 @@
-Version: 2.0.0
-Date: 2023-03-12 12:42:08 UTC
-SHA: 80cfc503c29ad48806e526b97d4570600bbd5420
+Version: 2.1.1
+Date: 2023-10-20 16:05:16 UTC
+SHA: ca72a646d041f7f096c4e196e8ae2fb2b176019c

DESCRIPTION

@@ -1,6 +1,6 @@
 Package: AMR
-Version: 2.0.0.9040
-Date: 2023-07-12
+Version: 2.1.1
+Date: 2023-10-20
 Title: Antimicrobial Resistance Data Analysis
 Description: Functions to simplify and standardise antimicrobial resistance (AMR)
   data analysis and to work with microbial and antimicrobial properties by

NAMESPACE

@@ -1,22 +1,8 @@
 # Generated by roxygen2: do not edit by hand
 
-S3method("!",mic)
 S3method("!=",ab_selector)
-S3method("!=",mic)
-S3method("%%",mic)
-S3method("%/%",mic)
 S3method("&",ab_selector)
-S3method("&",mic)
-S3method("*",mic)
-S3method("+",mic)
-S3method("-",mic)
-S3method("/",mic)
-S3method("<",mic)
-S3method("<=",mic)
 S3method("==",ab_selector)
-S3method("==",mic)
-S3method(">",mic)
-S3method(">=",mic)
 S3method("[",ab)
 S3method("[",av)
 S3method("[",disk)
@@ -41,18 +27,15 @@ S3method("[[<-",mic)
 S3method("[[<-",mo)
 S3method("[[<-",rsi)
 S3method("[[<-",sir)
-S3method("^",mic)
 S3method("|",ab_selector)
-S3method("|",mic)
-S3method(abs,mic)
-S3method(acos,mic)
-S3method(acosh,mic)
+S3method(Complex,mic)
+S3method(Math,mic)
+S3method(Ops,mic)
+S3method(Summary,mic)
 S3method(all,ab_selector)
 S3method(all,ab_selector_any_all)
-S3method(all,mic)
 S3method(any,ab_selector)
 S3method(any,ab_selector_any_all)
-S3method(any,mic)
 S3method(as.data.frame,ab)
 S3method(as.data.frame,av)
 S3method(as.data.frame,mo)
@@ -69,10 +52,6 @@ S3method(as.sir,data.frame)
 S3method(as.sir,default)
 S3method(as.sir,disk)
 S3method(as.sir,mic)
-S3method(asin,mic)
-S3method(asinh,mic)
-S3method(atan,mic)
-S3method(atanh,mic)
 S3method(barplot,antibiogram)
 S3method(barplot,disk)
 S3method(barplot,mic)
@@ -88,34 +67,15 @@ S3method(c,mic)
 S3method(c,mo)
 S3method(c,rsi)
 S3method(c,sir)
-S3method(ceiling,mic)
 S3method(close,progress_bar)
-S3method(cos,mic)
-S3method(cosh,mic)
-S3method(cospi,mic)
-S3method(cummax,mic)
-S3method(cummin,mic)
-S3method(cumprod,mic)
-S3method(cumsum,mic)
-S3method(digamma,mic)
 S3method(droplevels,mic)
 S3method(droplevels,rsi)
 S3method(droplevels,sir)
-S3method(exp,mic)
-S3method(expm1,mic)
-S3method(floor,mic)
 S3method(format,bug_drug_combinations)
-S3method(gamma,mic)
 S3method(hist,mic)
 S3method(kurtosis,data.frame)
 S3method(kurtosis,default)
 S3method(kurtosis,matrix)
-S3method(lgamma,mic)
-S3method(log,mic)
-S3method(log10,mic)
-S3method(log1p,mic)
-S3method(log2,mic)
-S3method(max,mic)
 S3method(mean,mic)
 S3method(mean_amr_distance,data.frame)
 S3method(mean_amr_distance,default)
@@ -123,7 +83,6 @@ S3method(mean_amr_distance,disk)
 S3method(mean_amr_distance,mic)
 S3method(mean_amr_distance,sir)
 S3method(median,mic)
-S3method(min,mic)
 S3method(plot,antibiogram)
 S3method(plot,disk)
 S3method(plot,mic)
@@ -143,9 +102,7 @@ S3method(print,mo_uncertainties)
 S3method(print,pca)
 S3method(print,rsi)
 S3method(print,sir)
-S3method(prod,mic)
 S3method(quantile,mic)
-S3method(range,mic)
 S3method(rep,ab)
 S3method(rep,av)
 S3method(rep,disk)
@@ -153,28 +110,15 @@ S3method(rep,mic)
 S3method(rep,mo)
 S3method(rep,rsi)
 S3method(rep,sir)
-S3method(round,mic)
-S3method(sign,mic)
-S3method(signif,mic)
-S3method(sin,mic)
-S3method(sinh,mic)
-S3method(sinpi,mic)
 S3method(skewness,data.frame)
 S3method(skewness,default)
 S3method(skewness,matrix)
 S3method(sort,mic)
-S3method(sqrt,mic)
-S3method(sum,mic)
 S3method(summary,mic)
 S3method(summary,mo)
 S3method(summary,pca)
 S3method(summary,rsi)
 S3method(summary,sir)
-S3method(tan,mic)
-S3method(tanh,mic)
-S3method(tanpi,mic)
-S3method(trigamma,mic)
-S3method(trunc,mic)
 S3method(unique,ab)
 S3method(unique,av)
 S3method(unique,disk)

NEWS.md

@@ -1,10 +1,23 @@
-# AMR 2.0.0.9040
+# AMR 2.1.1
+
+* Fix for selecting first isolates using the phenotype-based method
+  * This included too many isolates when patients had altering antibiograms within the same bacterial species
+  * See for more info [our issue #122](https://github.com/msberends/AMR/issues/122)
+* Added 1,366 LOINC codes to the `antibiotics` data set and updated to the latest version (LOINC v2.76)
+* MICs can now be used in complex number calculations and allow scientific number format as input (e.g., `as.mic("1.28e-2")`)
+* Fix rounding MICs on latest R beta ('R-devel')
+* Removed unneeded note about the used language when option `AMR_locale` is set
+* Fixed non-ASCII characters in documentation, according to CRAN maintainers
+
+
+# AMR 2.1.0
 
 ## New
-* Clinical breakpoints and intrinsic resistance of EUCAST 2023 and CLSI 2023 have been added for `as.sir()`. EUCAST 2023 (v13.0) is now the new default guideline for all MIC and disks diffusion interpretations
-* The EUCAST dosage guideline of v13.0 has been added to the `dosage` data set
-* ECOFF: the `clinical_breakpoints` data set now contains epidemiological cut-off (ECOFF) values. These ECOFFs can be used for MIC/disk interpretation using `as.sir(..., breakpoint_type = "ECOFF")`, which is an important new addition for veterinary microbiology.
-* Added support for 29 species groups / complexes. They are gathered in a new data set `microorganisms.groups` and are used in clinical breakpoint interpretation. For example, CLSI 2023 contains breakpoints for the RGM group (Rapidly Growing Mycobacterium, containing over 80 species) which is now supported by our package.
+* Regarding clinical breakpoints:
+  * Clinical breakpoints and intrinsic resistance of EUCAST 2023 and CLSI 2023 have been added to the `clinical_breakpoints` data set for usage in `as.sir()`. EUCAST 2023 (v13.0) is now the new default guideline for all MIC and disks diffusion interpretations
+  * The EUCAST dosage guideline of v13.0 has been added to the `dosage` data set
+  * The `clinical_breakpoints` data set now also contains epidemiological cut-off (ECOFF) values and CLSI animal breakpoints. These two new breakpoint types can be used for MIC/disk interpretation using `as.sir(..., breakpoint_type = "ECOFF")` or`as.sir(..., breakpoint_type = "animal")`, which is an important new addition for veterinary microbiology.
+* Added support for 30 species groups / complexes. They are gathered in a new data set `microorganisms.groups` and are used in clinical breakpoint interpretation. For example, CLSI 2023 contains breakpoints for the RGM group (Rapidly Growing Mycobacterium, containing over 80 species) which is now supported by our package.
 * Added oxygen tolerance from BacDive to over 25,000 bacteria in the `microorganisms` data set
   * Added `mo_oxygen_tolerance()` to retrieve the values
   * Added `mo_is_anaerobic()` to determine which genera/species are obligate anaerobic bacteria
@@ -14,6 +27,7 @@
 
 ## Changed
 * Updated algorithm of `as.mo()` by giving more weight to fungi
+* Fixed clinical breakpoints errors introduced by the source we import the rules from
 * `mo_rank()` now returns `NA` for 'unknown' microorganisms (`B_ANAER`, `B_ANAER-NEG`, `B_ANAER-POS`, `B_GRAMN`, `B_GRAMP`, `F_FUNGUS`, `F_YEAST`, and `UNKNOWN`)
 * When printing microorganism or antibiotic codes in a tibble, a mouse-hover now shows the full name of the code
 * Plots for MIC and disk diffusion values:
@@ -189,4 +203,4 @@ We now added extensive support for antiviral agents! For the first time, the `AM
 
 ----
 
-This changelog only contains changes from AMR v2.0 and later. For prior versions, please see [our archive](https://github.com/msberends/AMR/blob/v1.8.2/NEWS.md).
+This changelog only contains changes from AMR v2.0 (January 2023) and later. For prior versions, please see [our archive](https://github.com/msberends/AMR/blob/v1.8.2/NEWS.md).

R/aa_amr-package.R

@@ -34,9 +34,9 @@
 #'
 #' The `AMR` package is a [free and open-source](https://msberends.github.io/AMR/#copyright) R package with [zero dependencies](https://en.wikipedia.org/wiki/Dependency_hell) to simplify the analysis and prediction of Antimicrobial Resistance (AMR) and to work with microbial and antimicrobial data and properties, by using evidence-based methods. **Our aim is to provide a standard** for clean and reproducible AMR data analysis, that can therefore empower epidemiological analyses to continuously enable surveillance and treatment evaluation in any setting. [Many different researchers](https://msberends.github.io/AMR/authors.html) from around the globe are continually helping us to make this a successful and durable project!
 #'
-#' This work was published in the Journal of Statistical Software (Volume 104(3); \doi{jss.v104.i03}) and formed the basis of two PhD theses (\doi{10.33612/diss.177417131} and \doi{10.33612/diss.192486375}).
+#' This work was published in the Journal of Statistical Software (Volume 104(3); \doi{10.18637/jss.v104.i03}) and formed the basis of two PhD theses (\doi{10.33612/diss.177417131} and \doi{10.33612/diss.192486375}).
 #'
-#' After installing this package, R knows [**`r format_included_data_number(AMR::microorganisms)` microorganisms**](https://msberends.github.io/AMR/reference/microorganisms.html) (updated `r format(TAXONOMY_VERSION$GBIF$accessed_date, "%B %Y")`) and all [**`r format_included_data_number(nrow(AMR::antibiotics) + nrow(AMR::antivirals))` antibiotic, antimycotic and antiviral drugs**](https://msberends.github.io/AMR/reference/antibiotics.html) by name and code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC and SNOMED CT), and knows all about valid SIR and MIC values. The integral clinical breakpoint guidelines from CLSI and EUCAST are included, even with epidemiological cut-off (ECOFF) values. It supports and can read any data format, including WHONET data. This package works on Windows, macOS and Linux with all versions of R since R-3.0 (April 2013). **It was designed to work in any setting, including those with very limited resources**. It was created for both routine data analysis and academic research at the Faculty of Medical Sciences of the [University of Groningen](https://www.rug.nl), in collaboration with non-profit organisations [Certe Medical Diagnostics and Advice Foundation](https://www.certe.nl) and [University Medical Center Groningen](https://www.umcg.nl).
+#' After installing this package, R knows [**`r format_included_data_number(AMR::microorganisms)` microorganisms**](https://msberends.github.io/AMR/reference/microorganisms.html) (updated `r format(TAXONOMY_VERSION$GBIF$accessed_date, "%B %Y")`) and all [**`r format_included_data_number(nrow(AMR::antibiotics) + nrow(AMR::antivirals))` antibiotic, antimycotic and antiviral drugs**](https://msberends.github.io/AMR/reference/antibiotics.html) by name and code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC and SNOMED CT), and knows all about valid SIR and MIC values. The integral clinical breakpoint guidelines from CLSI and EUCAST are included, even with epidemiological cut-off (ECOFF) values. It supports and can read any data format, including WHONET data. This package works on Windows, macOS and Linux with all versions of R since R-3.0 (April 2013). **It was designed to work in any setting, including those with very limited resources**. It was created for both routine data analysis and academic research at the Faculty of Medical Sciences of the public [University of Groningen](https://www.rug.nl), in collaboration with non-profit organisations [Certe Medical Diagnostics and Advice Foundation](https://www.certe.nl) and [University Medical Center Groningen](https://www.umcg.nl).
 #'
 #' The `AMR` package is available in `r vector_and(vapply(FUN.VALUE = character(1), LANGUAGES_SUPPORTED_NAMES, function(x) x$exonym), quotes = FALSE, sort = FALSE)`. Antimicrobial drug (group) names and colloquial microorganism names are provided in these languages.
 #' @section Reference Data Publicly Available:
@@ -44,7 +44,7 @@
 #' @source
 #' To cite AMR in publications use:
 #'
-#' Berends MS, Luz CF, Friedrich AW, Sinha BNM, Albers CJ, Glasner C (2022). "AMR: An R Package for Working with Antimicrobial Resistance Data." _Journal of Statistical Software_, *104*(3), 1-31. \doi{10.18637/jss.v104.i03}.
+#' Berends MS, Luz CF, Friedrich AW, Sinha BNM, Albers CJ, Glasner C (2022). "AMR: An R Package for Working with Antimicrobial Resistance Data." _Journal of Statistical Software_, *104*(3), 1-31. \doi{10.18637/jss.v104.i03}
 #'
 #' A BibTeX entry for LaTeX users is:
 #'

R/aa_globals.R

@@ -102,17 +102,18 @@ TAXONOMY_VERSION <- list(
   ),
   SNOMED = list(
     accessed_date = as.Date("2021-07-01"),
-    citation = "Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microoganism', OID 2.16.840.1.114222.4.11.1009 (v12).",
+    citation = "Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microorganism', OID 2.16.840.1.114222.4.11.1009 (v12).",
     url = "https://phinvads.cdc.gov"
   ),
   LOINC = list(
-    accessed_date = as.Date("2022-10-30"),
-    citation = "Logical Observation Identifiers Names and Codes (LOINC), Version 2.73 (8 August, 2022).",
+    accessed_date = as.Date("2023-10-19"),
+    citation = "Logical Observation Identifiers Names and Codes (LOINC), Version 2.76 (18 September, 2023).",
     url = "https://loinc.org"
   )
 )
 
 globalVariables(c(
+  ".GenericCallEnv",
   ".mo",
   ".rowid",
   ".syndromic_group",

R/aa_helper_functions.R

@@ -502,19 +502,24 @@ word_wrap <- function(...,
 
   # format backticks
   if (pkg_is_available("cli") &&
-      tryCatch(getExportedValue("isAvailable", ns = asNamespace("rstudioapi"))(), error = function(e) return(FALSE))) {
+      tryCatch(isTRUE(getExportedValue("ansi_has_hyperlink_support", ns = asNamespace("cli"))()), error = function(e) FALSE) &&
+      tryCatch(getExportedValue("isAvailable", ns = asNamespace("rstudioapi"))(), error = function(e) return(FALSE)) && 
+      tryCatch(getExportedValue("versionInfo", ns = asNamespace("rstudioapi"))()$version > "2023.6.0.0", error = function(e) return(FALSE))) {
+    # we are in a recent version of RStudio, so do something nice: add links to our help pages in the console.
     parts <- strsplit(msg, "`", fixed = TRUE)[[1]]
     cmds <- parts %in% paste0(ls(envir = asNamespace("AMR")), "()")
     # functions with a dot are not allowed: https://github.com/rstudio/rstudio/issues/11273#issuecomment-1156193252
+    # lead them to the help page of our package
     parts[cmds & parts %like% "[.]"] <- font_url(url = paste0("ide:help:AMR::", gsub("()", "", parts[cmds & parts %like% "[.]"], fixed = TRUE)),
                                                  txt = parts[cmds & parts %like% "[.]"])
+    # otherwise, give a 'click to run' popup
     parts[cmds & parts %unlike% "[.]"] <- font_url(url = paste0("ide:run:AMR::", parts[cmds & parts %unlike% "[.]"]),
                                                    txt = parts[cmds & parts %unlike% "[.]"])
     msg <- paste0(parts, collapse = "`")
   }
   msg <- gsub("`(.+?)`", font_grey_bg("\\1"), msg)
   
-  # clean introduced whitespace between fullstops
+  # clean introduced whitespace in between fullstops
   msg <- gsub("[.] +[.]", "..", msg)
   # remove extra space that was introduced (e.g. "Smith et al. , 2022")
   msg <- gsub(". ,", ".,", msg, fixed = TRUE)

R/data.R

@@ -32,9 +32,9 @@
 #' Two data sets containing all antibiotics/antimycotics and antivirals. Use [as.ab()] or one of the [`ab_*`][ab_property()] functions to retrieve values from the [antibiotics] data set. Three identifiers are included in this data set: an antibiotic ID (`ab`, primarily used in this package) as defined by WHONET/EARS-Net, an ATC code (`atc`) as defined by the WHO, and a Compound ID (`cid`) as found in PubChem. Other properties in this data set are derived from one or more of these codes. Note that some drugs have multiple ATC codes.
 #' @format
 #' ### For the [antibiotics] data set: a [tibble][tibble::tibble] with `r nrow(antibiotics)` observations and `r ncol(antibiotics)` variables:
-#' - `ab`\cr Antibiotic ID as used in this package (such as `AMC`), using the official EARS-Net (European Antimicrobial Resistance Surveillance Network) codes where available
-#' - `cid`\cr Compound ID as found in PubChem
-#' - `name`\cr Official name as used by WHONET/EARS-Net or the WHO
+#' - `ab`\cr Antibiotic ID as used in this package (such as `AMC`), using the official EARS-Net (European Antimicrobial Resistance Surveillance Network) codes where available. *This is a unique identifier.*
+#' - `cid`\cr Compound ID as found in PubChem. *This is a unique identifier.*
+#' - `name`\cr Official name as used by WHONET/EARS-Net or the WHO. *This is a unique identifier.*
 #' - `group`\cr A short and concise group name, based on WHONET and WHOCC definitions
 #' - `atc`\cr ATC codes (Anatomical Therapeutic Chemical) as defined by the WHOCC, like `J01CR02`
 #' - `atc_group1`\cr Official pharmacological subgroup (3rd level ATC code) as defined by the WHOCC, like `"Macrolides, lincosamides and streptogramins"`
@@ -45,20 +45,20 @@
 #' - `oral_units`\cr Units of `oral_ddd`
 #' - `iv_ddd`\cr Defined Daily Dose (DDD), parenteral (intravenous) treatment, currently available for `r sum(!is.na(antibiotics$iv_ddd))` drugs
 #' - `iv_units`\cr Units of `iv_ddd`
-#' - `loinc`\cr All LOINC codes (Logical Observation Identifiers Names and Codes) associated with the name of the antimicrobial drug. Use [ab_loinc()] to retrieve them quickly, see [ab_property()].
+#' - `loinc`\cr All codes associated with the name of the antimicrobial drug from `r TAXONOMY_VERSION$LOINC$citation` Use [ab_loinc()] to retrieve them quickly, see [ab_property()].
 #'
 #' ### For the [antivirals] data set: a [tibble][tibble::tibble] with `r nrow(antivirals)` observations and `r ncol(antivirals)` variables:
-#' - `av`\cr Antibiotic ID as used in this package (such as `AMC`), using the official EARS-Net (European Antimicrobial Resistance Surveillance Network) codes where available
-#' - `name`\cr Official name as used by WHONET/EARS-Net or the WHO
+#' - `av`\cr Antiviral ID as used in this package (such as `ACI`), using the official EARS-Net (European Antimicrobial Resistance Surveillance Network) codes where available. *This is a unique identifier.* Combinations are codes that contain a `+` to indicate this, such as `ATA+COBI` for atazanavir/cobicistat.
+#' - `name`\cr Official name as used by WHONET/EARS-Net or the WHO. *This is a unique identifier.*
 #' - `atc`\cr ATC codes (Anatomical Therapeutic Chemical) as defined by the WHOCC
-#' - `cid`\cr Compound ID as found in PubChem
+#' - `cid`\cr Compound ID as found in PubChem. *This is a unique identifier.*
 #' - `atc_group`\cr Official pharmacological subgroup (3rd level ATC code) as defined by the WHOCC
 #' - `synonyms`\cr Synonyms (often trade names) of a drug, as found in PubChem based on their compound ID
 #' - `oral_ddd`\cr Defined Daily Dose (DDD), oral treatment
 #' - `oral_units`\cr Units of `oral_ddd`
 #' - `iv_ddd`\cr Defined Daily Dose (DDD), parenteral treatment
 #' - `iv_units`\cr Units of `iv_ddd`
-#' - `loinc`\cr All LOINC codes (Logical Observation Identifiers Names and Codes) associated with the name of the antimicrobial drug.
+#' - `loinc`\cr All codes associated with the name of the antiviral drug from `r TAXONOMY_VERSION$LOINC$citation` Use [av_loinc()] to retrieve them quickly, see [av_property()].
 #' @details Properties that are based on an ATC code are only available when an ATC is available. These properties are: `atc_group1`, `atc_group2`, `oral_ddd`, `oral_units`, `iv_ddd` and `iv_units`.
 #'
 #' Synonyms (i.e. trade names) were derived from the PubChem Compound ID (column `cid`) and consequently only available where a CID is available.
@@ -86,12 +86,12 @@
 #'
 #' A data set containing the full microbial taxonomy (**last updated: `r documentation_date(max(TAXONOMY_VERSION$GBIF$accessed_date, TAXONOMY_VERSION$LPSN$accessed_date))`**) of `r nr2char(length(unique(microorganisms$kingdom[!microorganisms$kingdom %like% "unknown"])))` kingdoms from the List of Prokaryotic names with Standing in Nomenclature (LPSN) and the Global Biodiversity Information Facility (GBIF). This data set is the backbone of this `AMR` package. MO codes can be looked up using [as.mo()].
 #' @format A [tibble][tibble::tibble] with `r format(nrow(microorganisms), big.mark = " ")` observations and `r ncol(microorganisms)` variables:
-#' - `mo`\cr ID of microorganism as used by this package
-#' - `fullname`\cr Full name, like `"Escherichia coli"`. For the taxonomic ranks genus, species and subspecies, this is the 'pasted' text of genus, species, and subspecies. For all taxonomic ranks higher than genus, this is the name of the taxon.
+#' - `mo`\cr ID of microorganism as used by this package. *This is a unique identifier.*
+#' - `fullname`\cr Full name, like `"Escherichia coli"`. For the taxonomic ranks genus, species and subspecies, this is the 'pasted' text of genus, species, and subspecies. For all taxonomic ranks higher than genus, this is the name of the taxon. *This is a unique identifier.*
 #' - `status` \cr Status of the taxon, either `r vector_or(microorganisms$status)`
 #' - `kingdom`, `phylum`, `class`, `order`, `family`, `genus`, `species`, `subspecies`\cr Taxonomic rank of the microorganism
 #' - `rank`\cr Text of the taxonomic rank of the microorganism, such as `"species"` or `"genus"`
-#' - `ref`\cr Author(s) and year of related scientific publication. This contains only the *first surname* and year of the *latest* authors, e.g. "Wallis *et al.* 2006 *emend.* Smith and Jones 2018" becomes "Smith *et al.*, 2018". This field is directly retrieved from the source specified in the column `source`. Moreover, accents were removed to comply with CRAN that only allows ASCII characters, e.g. "V`r "\u00e1\u0148ov\u00e1"`" becomes "Vanova".
+#' - `ref`\cr Author(s) and year of related scientific publication. This contains only the *first surname* and year of the *latest* authors, e.g. "Wallis *et al.* 2006 *emend.* Smith and Jones 2018" becomes "Smith *et al.*, 2018". This field is directly retrieved from the source specified in the column `source`. Moreover, accents were removed to comply with CRAN that only allows ASCII characters.
 #' - `lpsn`\cr Identifier ('Record number') of the List of Prokaryotic names with Standing in Nomenclature (LPSN). This will be the first/highest LPSN identifier to keep one identifier per row. For example, *Acetobacter ascendens* has LPSN Record number 7864 and 11011. Only the first is available in the `microorganisms` data set.
 #' - `oxygen_tolerance` \cr Oxygen tolerance, either `r vector_or(microorganisms$oxygen_tolerance)`. These data were retrieved from BacDive (see *Source*). Items that contain "likely" are missing from BacDive and were extrapolated from other species within the same genus to guess the oxygen tolerance. Currently `r round(length(microorganisms$oxygen_tolerance[which(!is.na(microorganisms$oxygen_tolerance))]) / nrow(microorganisms[which(microorganisms$kingdom == "Bacteria"), ]) * 100, 1)`% of all `r format_included_data_number(nrow(microorganisms[which(microorganisms$kingdom == "Bacteria"), ]))` bacteria in the data set contain an oxygen tolerance.
 #' - `lpsn_parent`\cr LPSN identifier of the parent taxon
@@ -156,7 +156,7 @@
 #'
 #' A data set containing commonly used codes for microorganisms, from laboratory systems and [WHONET](https://whonet.org). Define your own with [set_mo_source()]. They will all be searched when using [as.mo()] and consequently all the [`mo_*`][mo_property()] functions.
 #' @format A [tibble][tibble::tibble] with `r format(nrow(microorganisms.codes), big.mark = " ")` observations and `r ncol(microorganisms.codes)` variables:
-#' - `code`\cr Commonly used code of a microorganism
+#' - `code`\cr Commonly used code of a microorganism. *This is a unique identifier.*
 #' - `mo`\cr ID of the microorganism in the [microorganisms] data set
 #' @details
 #' Like all data sets in this package, this data set is publicly available for download in the following formats: R, MS Excel, Apache Feather, Apache Parquet, SPSS, SAS, and Stata. Please visit [our website for the download links](https://msberends.github.io/AMR/articles/datasets.html). The actual files are of course available on [our GitHub repository](https://github.com/msberends/AMR/tree/main/data-raw).
@@ -286,7 +286,7 @@
 #' Clinical breakpoints in this package were validated through and imported from [WHONET](https://whonet.org), a free desktop Windows application developed and supported by the WHO Collaborating Centre for Surveillance of Antimicrobial Resistance. More can be read on [their website](https://whonet.org). The developers of WHONET and this `AMR` package have been in contact about sharing their work. We highly appreciate their development on the WHONET software.
 #' 
 #' ### Response from CLSI and EUCAST
-#' The CEO of CLSI and the chairman of EUCAST have endorsed the work and public use of this `AMR` package in June 2023, when future development of distributing clinical breakpoints was discussed in a meeting between CLSI, EUCAST, the WHO, and developers of WHONET and the `AMR` package.
+#' The CEO of CLSI and the chairman of EUCAST have endorsed the work and public use of this `AMR` package (and consequently the use of their breakpoints) in June 2023, when future development of distributing clinical breakpoints was discussed in a meeting between CLSI, EUCAST, the WHO, and developers of WHONET and the `AMR` package.
 #' 
 #' ### Download
 #' Like all data sets in this package, this data set is publicly available for download in the following formats: R, MS Excel, Apache Feather, Apache Parquet, SPSS, SAS, and Stata. Please visit [our website for the download links](https://msberends.github.io/AMR/articles/datasets.html). The actual files are of course available on [our GitHub repository](https://github.com/msberends/AMR/tree/main/data-raw). They allow for machine reading EUCAST and CLSI guidelines, which is almost impossible with the MS Excel and PDF files distributed by EUCAST and CLSI, though initiatives have started to overcome these burdens.

R/first_isolate.R

@@ -347,8 +347,8 @@ first_isolate <- function(x = NULL,
 
   # create original row index
   x$newvar_row_index <- seq_len(nrow(x))
-  x$newvar_mo <- as.mo(x[, col_mo, drop = TRUE])
-  x$newvar_genus_species <- paste(mo_genus(x$newvar_mo), mo_species(x$newvar_mo))
+  x$newvar_mo <- as.mo(x[, col_mo, drop = TRUE], keep_synonyms = TRUE, info = FALSE)
+  x$newvar_genus_species <- paste(mo_genus(x$newvar_mo, keep_synonyms = TRUE, info = FALSE), mo_species(x$newvar_mo, keep_synonyms = TRUE, info = FALSE))
   x$newvar_date <- x[, col_date, drop = TRUE]
   x$newvar_patient_id <- as.character(x[, col_patient_id, drop = TRUE])
 
@@ -443,7 +443,7 @@ first_isolate <- function(x = NULL,
   # did find some isolates - add new index numbers of rows
   x$newvar_row_index_sorted <- seq_len(nrow(x))
 
-  scope.size <- nrow(x[which(x$newvar_row_index_sorted %in% c(row.start + 1:row.end) &
+  scope.size <- nrow(x[which(x$newvar_row_index_sorted %in% seq(row.start, row.end, 1) &
     !is.na(x$newvar_mo)), , drop = FALSE])
 
   # Analysis of first isolate ----
@@ -467,41 +467,45 @@ first_isolate <- function(x = NULL,
 
   x$other_pat_or_mo <- !(x$newvar_patient_id == pm_lag(x$newvar_patient_id) & x$newvar_genus_species == pm_lag(x$newvar_genus_species))
 
-  x$episode_group <- paste(x$newvar_patient_id, x$newvar_genus_species)
-
+  x$newvar_episode_group <- paste(x$newvar_patient_id, x$newvar_genus_species)
+  
   x$more_than_episode_ago <- unlist(
     lapply(
       split(
         x$newvar_date,
-        x$episode_group
+        x$newvar_episode_group
       ),
       is_new_episode,
-      episode_days = episode_days
+      episode_days = episode_days,
+      drop = FALSE
     ),
     use.names = FALSE
   )
-
+  
   if (!is.null(col_keyantimicrobials)) {
-    # with key antibiotics
-    x$other_key_ab <- !antimicrobials_equal(
-      y = x$newvar_key_ab,
-      z = pm_lag(x$newvar_key_ab),
-      type = type,
-      ignore_I = ignore_I,
-      points_threshold = points_threshold
+    # using phenotypes
+    x$different_antibiogram <- !unlist(
+      lapply(
+        split(
+          x$newvar_key_ab,
+          x$newvar_episode_group
+        ),
+        duplicated_antibiogram,
+        points_threshold = points_threshold,
+        ignore_I = ignore_I,
+        type = type
+      ),
+      use.names = FALSE
     )
-    x$newvar_first_isolate <- x$newvar_row_index_sorted >= row.start &
-      x$newvar_row_index_sorted <= row.end &
-      x$newvar_genus_species != "" &
-      (x$other_pat_or_mo | x$more_than_episode_ago | x$other_key_ab)
   } else {
-    # no key antibiotics
-    x$newvar_first_isolate <- x$newvar_row_index_sorted >= row.start &
-      x$newvar_row_index_sorted <= row.end &
-      x$newvar_genus_species != "" &
-      (x$other_pat_or_mo | x$more_than_episode_ago)
+    x$different_antibiogram <- FALSE
   }
   
+  x$newvar_first_isolate <- x$newvar_row_index_sorted >= row.start &
+    x$newvar_row_index_sorted <= row.end &
+    x$newvar_genus_species != "" &
+    (x$other_pat_or_mo | x$more_than_episode_ago | x$different_antibiogram)
+  
   decimal.mark <- getOption("OutDec")
   big.mark <- ifelse(decimal.mark != ",", ",", " ")
   
@@ -664,3 +668,48 @@ coerce_method <- function(method) {
   method[method %like% "^(i$|iso)"] <- "isolate-based"
   method
 }
+
+duplicated_antibiogram <- function(antibiogram, points_threshold, ignore_I, type) {
+  if (length(antibiogram) == 1) {
+    # fast return, only 1 isolate
+    return(FALSE)
+  }
+  out <- rep(NA, length(antibiogram))
+  out[1] <- FALSE
+  out[2] <- antimicrobials_equal(antibiogram[1], antibiogram[2],
+                                 ignore_I = ignore_I, points_threshold = points_threshold,
+                                 type = type)
+  if (length(antibiogram) == 2) {
+    # fast return, no further check required
+    return(out)
+  }
+  
+  # sort after the second one (since we already determined AB equality of the first two)
+  original_sort <- c(1, 2, rank(antibiogram[3:length(antibiogram)]) + 2)
+  antibiogram.bak <- antibiogram
+  antibiogram <- c(antibiogram[1:2], sort(antibiogram[3:length(antibiogram)]))
+  
+  # we can skip the duplicates - they are never unique antibiograms of course
+  duplicates <- duplicated(antibiogram)
+  out[3:length(out)][duplicates[3:length(out)] == TRUE] <- TRUE
+  if (all(duplicates[3:length(out)] == TRUE, na.rm = TRUE)) {
+    # fast return, no further check required
+    return(c(out[1:2], rep(TRUE, length(out) - 2)))
+  }
+  
+  for (na in antibiogram[is.na(out)]) {
+    # check if this antibiogram has any change with other antibiograms
+    out[which(antibiogram == na)] <- all(
+      vapply(FUN.VALUE = logical(1),
+             antibiogram[!is.na(out) & antibiogram != na],
+             function(y) antimicrobials_equal(y = y, z = na,
+                                              ignore_I = ignore_I, points_threshold = points_threshold,
+                                              type = type)))
+  }
+  
+  out <- out[original_sort]
+  # rerun duplicated again
+  duplicates <- duplicated(antibiogram.bak)
+  out[duplicates == TRUE] <- TRUE
+  out
+}

R/get_episode.R

@@ -221,11 +221,11 @@ exec_episode <- function(x, episode_days, case_free_days, ...) {
 
   # running as.double() on a POSIXct object will return its number of seconds since 1970-01-01
   x <- as.double(as.POSIXct(x)) # as.POSIXct() required for Date classes
-
+  
   # since x is now in seconds, get seconds from episode_days as well
   episode_seconds <- episode_days * 60 * 60 * 24
   case_free_seconds <- case_free_days * 60 * 60 * 24
-
+  
   if (length(x) == 1) { # this will also match 1 NA, which is fine
     return(1)
   } else if (length(x) == 2 && all(!is.na(x))) {
@@ -241,7 +241,7 @@ exec_episode <- function(x, episode_days, case_free_days, ...) {
     }
   }
 
-  run_episodes <- function(x, episode_seconds, case_free) {
+  run_episodes <- function(x, episode_sec, case_free_sec) {
     NAs <- which(is.na(x))
     x[NAs] <- 0
 
@@ -250,8 +250,8 @@ exec_episode <- function(x, episode_days, case_free_days, ...) {
     ind <- 1
     indices[ind] <- 1
     for (i in 2:length(x)) {
-      if ((length(episode_seconds) > 0 && (x[i] - start) >= episode_seconds) ||
-        (length(case_free_seconds) > 0 && (x[i] - x[i - 1]) >= case_free_seconds)) {
+      if ((length(episode_sec) > 0 && (x[i] - start) >= episode_sec) ||
+        (length(case_free_sec) > 0 && (x[i] - x[i - 1]) >= case_free_sec)) {
         ind <- ind + 1
         start <- x[i]
       }

R/mdro.R

@@ -203,7 +203,7 @@ mdro <- function(x = NULL,
   }
 
   info.bak <- info
-  # don't thrown info's more than once per call
+  # don't throw info's more than once per call
   if (isTRUE(info)) {
     info <- message_not_thrown_before("mdro")
   }
@@ -1611,10 +1611,12 @@ mdro <- function(x = NULL,
     function(y) all(is.na(y))
   ))
   if (length(rows_empty) > 0) {
-    cat(font_italic(paste0(" (", length(rows_empty), " isolates had no test results)\n")))
+    if (isTRUE(info.bak)) {
+      cat(font_italic(paste0(" (", length(rows_empty), " isolates had no test results)\n")))
+    }
     x[rows_empty, "MDRO"] <- NA
     x[rows_empty, "reason"] <- "none of the antibiotics have test results"
-  } else {
+  } else if (isTRUE(info.bak)) {
     cat("\n")
   }
 

R/mic.R

@@ -161,9 +161,6 @@ valid_mic_levels <- c(
 #' if (require("ggplot2")) {
 #'   autoplot(mic_data, mo = "E. coli", ab = "cipro", language = "nl") # Dutch
 #' }
-#' if (require("ggplot2")) {
-#'   autoplot(mic_data, mo = "E. coli", ab = "cipro", language = "uk") # Ukrainian
-#' }
 as.mic <- function(x, na.rm = FALSE) {
   meet_criteria(x, allow_NA = TRUE)
   meet_criteria(na.rm, allow_class = "logical", has_length = 1)
@@ -184,6 +181,8 @@ as.mic <- function(x, na.rm = FALSE) {
 
     # comma to period
     x <- gsub(",", ".", x, fixed = TRUE)
+    # transform scientific notation
+    x[x %like% "[-]?[0-9]+([.][0-9]+)?e[-]?[0-9]+"] <- as.double(x[x %like% "[-]?[0-9]+([.][0-9]+)?e[-]?[0-9]+"])
     # transform Unicode for >= and <=
     x <- gsub("\u2264", "<=", x, fixed = TRUE)
     x <- gsub("\u2265", ">=", x, fixed = TRUE)
@@ -462,399 +461,46 @@ quantile.mic <- function(x, probs = seq(0, 1, 0.25), na.rm = FALSE,
   quantile(as.double(x), probs = probs, na.rm = na.rm, names = names, type = type, ...)
 }
 
-# Math (see ?groupGeneric) ----------------------------------------------
+# Math (see ?groupGeneric) ------------------------------------------------
 
-#' @method abs mic
 #' @export
-#' @noRd
-abs.mic <- function(x) {
-  abs(as.double(x))
-}
-#' @method sign mic
-#' @export
-#' @noRd
-sign.mic <- function(x) {
-  sign(as.double(x))
-}
-#' @method sqrt mic
-#' @export
-#' @noRd
-sqrt.mic <- function(x) {
-  sqrt(as.double(x))
-}
-#' @method floor mic
-#' @export
-#' @noRd
-floor.mic <- function(x) {
-  floor(as.double(x))
-}
-#' @method ceiling mic
-#' @export
-#' @noRd
-ceiling.mic <- function(x) {
-  ceiling(as.double(x))
-}
-#' @method trunc mic
-#' @export
-#' @noRd
-trunc.mic <- function(x, ...) {
-  trunc(as.double(x), ...)
-}
-#' @method round mic
-#' @export
-#' @noRd
-round.mic <- function(x, digits = 0) {
-  round(as.double(x), digits = digits)
-}
-#' @method signif mic
-#' @export
-#' @noRd
-signif.mic <- function(x, digits = 6) {
-  signif(as.double(x), digits = digits)
-}
-#' @method exp mic
-#' @export
-#' @noRd
-exp.mic <- function(x) {
-  exp(as.double(x))
-}
-#' @method log mic
-#' @export
-#' @noRd
-log.mic <- function(x, base = exp(1)) {
-  log(as.double(x), base = base)
-}
-#' @method log10 mic
-#' @export
-#' @noRd
-log10.mic <- function(x) {
-  log10(as.double(x))
-}
-#' @method log2 mic
-#' @export
-#' @noRd
-log2.mic <- function(x) {
-  log2(as.double(x))
-}
-#' @method expm1 mic
-#' @export
-#' @noRd
-expm1.mic <- function(x) {
-  expm1(as.double(x))
-}
-#' @method log1p mic
-#' @export
-#' @noRd
-log1p.mic <- function(x) {
-  log1p(as.double(x))
-}
-#' @method cos mic
-#' @export
-#' @noRd
-cos.mic <- function(x) {
-  cos(as.double(x))
-}
-#' @method sin mic
-#' @export
-#' @noRd
-sin.mic <- function(x) {
-  sin(as.double(x))
-}
-#' @method tan mic
-#' @export
-#' @noRd
-tan.mic <- function(x) {
-  tan(as.double(x))
-}
-#' @method cospi mic
-#' @export
-#' @noRd
-cospi.mic <- function(x) {
-  cospi(as.double(x))
-}
-#' @method sinpi mic
-#' @export
-#' @noRd
-sinpi.mic <- function(x) {
-  sinpi(as.double(x))
-}
-#' @method tanpi mic
-#' @export
-#' @noRd
-tanpi.mic <- function(x) {
-  tanpi(as.double(x))
-}
-#' @method acos mic
-#' @export
-#' @noRd
-acos.mic <- function(x) {
-  acos(as.double(x))
-}
-#' @method asin mic
-#' @export
-#' @noRd
-asin.mic <- function(x) {
-  asin(as.double(x))
-}
-#' @method atan mic
-#' @export
-#' @noRd
-atan.mic <- function(x) {
-  atan(as.double(x))
-}
-#' @method cosh mic
-#' @export
-#' @noRd
-cosh.mic <- function(x) {
-  cosh(as.double(x))
-}
-#' @method sinh mic
-#' @export
-#' @noRd
-sinh.mic <- function(x) {
-  sinh(as.double(x))
-}
-#' @method tanh mic
-#' @export
-#' @noRd
-tanh.mic <- function(x) {
-  tanh(as.double(x))
-}
-#' @method acosh mic
-#' @export
-#' @noRd
-acosh.mic <- function(x) {
-  acosh(as.double(x))
-}
-#' @method asinh mic
-#' @export
-#' @noRd
-asinh.mic <- function(x) {
-  asinh(as.double(x))
-}
-#' @method atanh mic
-#' @export
-#' @noRd
-atanh.mic <- function(x) {
-  atanh(as.double(x))
-}
-#' @method lgamma mic
-#' @export
-#' @noRd
-lgamma.mic <- function(x) {
-  lgamma(as.double(x))
-}
-#' @method gamma mic
-#' @export
-#' @noRd
-gamma.mic <- function(x) {
-  gamma(as.double(x))
-}
-#' @method digamma mic
-#' @export
-#' @noRd
-digamma.mic <- function(x) {
-  digamma(as.double(x))
-}
-#' @method trigamma mic
-#' @export
-#' @noRd
-trigamma.mic <- function(x) {
-  trigamma(as.double(x))
-}
-#' @method cumsum mic
-#' @export
-#' @noRd
-cumsum.mic <- function(x) {
-  cumsum(as.double(x))
-}
-#' @method cumprod mic
-#' @export
-#' @noRd
-cumprod.mic <- function(x) {
-  cumprod(as.double(x))
-}
-#' @method cummax mic
-#' @export
-#' @noRd
-cummax.mic <- function(x) {
-  cummax(as.double(x))
-}
-#' @method cummin mic
-#' @export
-#' @noRd
-cummin.mic <- function(x) {
-  cummin(as.double(x))
+Math.mic <- function(x, ...) {
+  x <- as.double(x)
+  # set class to numeric, because otherwise NextMethod will be factor (since mic is a factor)
+  .Class <- class(x)
+  NextMethod(.Generic)
 }
 
-# Ops (see ?groupGeneric) -----------------------------------------------
+# Ops (see ?groupGeneric) -------------------------------------------------
 
-is_greater <- function(el) {
-  el %like_case% ">[0-9]"
-}
-is_lower <- function(el) {
-  el %like_case% "<[0-9]"
+#' @export
+Ops.mic <- function(e1, e2) {
+  e1 <- as.double(e1)
+  if (!missing(e2)) {
+    # when e1 is `!`, e2 is missing
+    e2 <- as.double(e2)
+  }
+  # set class to numeric, because otherwise NextMethod will be factor (since mic is a factor)
+  .Class <- class(e1)
+  NextMethod(.Generic)
 }
 
-#' @method + mic
+# Complex (see ?groupGeneric) ---------------------------------------------
+
 #' @export
-#' @noRd
-`+.mic` <- function(e1, e2) {
-  as.double(e1) + as.double(e2)
+Complex.mic <- function(z) {
+  z <- as.double(z)
+  # set class to numeric, because otherwise NextMethod will be factor (since mic is a factor)
+  .Class <- class(z)
+  NextMethod(.Generic)
 }
 
-#' @method - mic
-#' @export
-#' @noRd
-`-.mic` <- function(e1, e2) {
-  as.double(e1) - as.double(e2)
-}
+# Summary (see ?groupGeneric) ---------------------------------------------
 
-#' @method * mic
 #' @export
-#' @noRd
-`*.mic` <- function(e1, e2) {
-  as.double(e1) * as.double(e2)
-}
-
-#' @method / mic
-#' @export
-#' @noRd
-`/.mic` <- function(e1, e2) {
-  as.double(e1) / as.double(e2)
-}
-
-#' @method ^ mic
-#' @export
-#' @noRd
-`^.mic` <- function(e1, e2) {
-  as.double(e1)^as.double(e2)
-}
-
-#' @method %% mic
-#' @export
-#' @noRd
-`%%.mic` <- function(e1, e2) {
-  as.double(e1) %% as.double(e2)
-}
-
-#' @method %/% mic
-#' @export
-#' @noRd
-`%/%.mic` <- function(e1, e2) {
-  as.double(e1) %/% as.double(e2)
-}
-
-#' @method & mic
-#' @export
-#' @noRd
-`&.mic` <- function(e1, e2) {
-  as.double(e1) & as.double(e2)
-}
-
-#' @method | mic
-#' @export
-#' @noRd
-`|.mic` <- function(e1, e2) {
-  as.double(e1) | as.double(e2)
-}
-
-#' @method ! mic
-#' @export
-#' @noRd
-`!.mic` <- function(x) {
-  !as.double(x)
-}
-
-#' @method == mic
-#' @export
-#' @noRd
-`==.mic` <- function(e1, e2) {
-  as.double(e1) == as.double(e2)
-}
-
-#' @method != mic
-#' @export
-#' @noRd
-`!=.mic` <- function(e1, e2) {
-  as.double(e1) != as.double(e2)
-}
-
-#' @method < mic
-#' @export
-#' @noRd
-`<.mic` <- function(e1, e2) {
-  as.double(e1) < as.double(e2)
-}
-
-#' @method <= mic
-#' @export
-#' @noRd
-`<=.mic` <- function(e1, e2) {
-  as.double(e1) <= as.double(e2)
-}
-
-#' @method >= mic
-#' @export
-#' @noRd
-`>=.mic` <- function(e1, e2) {
-  as.double(e1) >= as.double(e2)
-}
-
-#' @method > mic
-#' @export
-#' @noRd
-`>.mic` <- function(e1, e2) {
-  as.double(e1) > as.double(e2)
-  # doesn't work...
-  # nolint start
-  # as.double(e1) > as.double(e2) |
-  #   (as.double(e1) == as.double(e2) & is_lower(e2) & !is_lower(e1)) |
-  #   (as.double(e1) == as.double(e2) & is_greater(e1) & !is_greater(e2))
-  # nolint end
-}
-
-# Summary (see ?groupGeneric) -------------------------------------------
-
-#' @method all mic
-#' @export
-#' @noRd
-all.mic <- function(..., na.rm = FALSE) {
-  all(as.double(c(...)), na.rm = na.rm)
-}
-#' @method any mic
-#' @export
-#' @noRd
-any.mic <- function(..., na.rm = FALSE) {
-  any(as.double(c(...)), na.rm = na.rm)
-}
-#' @method sum mic
-#' @export
-#' @noRd
-sum.mic <- function(..., na.rm = FALSE) {
-  sum(as.double(c(...)), na.rm = na.rm)
-}
-#' @method prod mic
-#' @export
-#' @noRd
-prod.mic <- function(..., na.rm = FALSE) {
-  prod(as.double(c(...)), na.rm = na.rm)
-}
-#' @method min mic
-#' @export
-#' @noRd
-min.mic <- function(..., na.rm = FALSE) {
-  min(as.double(c(...)), na.rm = na.rm)
-}
-#' @method max mic
-#' @export
-#' @noRd
-max.mic <- function(..., na.rm = FALSE) {
-  max(as.double(c(...)), na.rm = na.rm)
-}
-#' @method range mic
-#' @export
-#' @noRd
-range.mic <- function(..., na.rm = FALSE) {
-  range(as.double(c(...)), na.rm = na.rm)
+Summary.mic <- function(..., na.rm = FALSE) {
+  # NextMethod() cannot be called from an anonymous function (`...`), so we get() the generic directly:
+  fn <- get(.Generic, envir = .GenericCallEnv)
+  fn(as.double(c(...)),
+     na.rm = na.rm)
 }

R/plot.R

@@ -65,7 +65,7 @@
 #' # when providing the microorganism and antibiotic, colours will show interpretations:
 #' plot(some_mic_values, mo = "S. aureus", ab = "ampicillin")
 #' plot(some_disk_values, mo = "Escherichia coli", ab = "cipro")
-#' plot(some_disk_values, mo = "Escherichia coli", ab = "cipro", language = "uk")
+#' plot(some_disk_values, mo = "Escherichia coli", ab = "cipro", language = "nl")
 #'
 #' \donttest{
 #' if (require("ggplot2")) {

R/proportion.R

@@ -46,13 +46,13 @@
 #' @param collapse a [logical] to indicate whether the output values should be 'collapsed', i.e. be merged together into one value, or a character value to use for collapsing
 #' @inheritSection as.sir Interpretation of SIR
 #' @details
+#' **Remember that you should filter your data to let it contain only first isolates!** This is needed to exclude duplicates and to reduce selection bias. Use [first_isolate()] to determine them in your data set with one of the four available algorithms.
+#' 
 #' The function [resistance()] is equal to the function [proportion_R()]. The function [susceptibility()] is equal to the function [proportion_SI()].
 #'
 #' Use [sir_confidence_interval()] to calculate the confidence interval, which relies on [binom.test()], i.e., the Clopper-Pearson method. This function returns a vector of length 2 at default for antimicrobial *resistance*. Change the `side` argument to "left"/"min" or "right"/"max" to return a single value, and change the `ab_result` argument to e.g. `c("S", "I")` to test for antimicrobial *susceptibility*, see Examples.
 #'
-#' **Remember that you should filter your data to let it contain only first isolates!** This is needed to exclude duplicates and to reduce selection bias. Use [first_isolate()] to determine them in your data set with one of the four available algorithms.
-#'
-#' These functions are not meant to count isolates, but to calculate the proportion of resistance/susceptibility. Use the [`count()`][AMR::count()] functions to count isolates. The function [susceptibility()] is essentially equal to `count_susceptible() / count_all()`. *Low counts can influence the outcome - the `proportion` functions may camouflage this, since they only return the proportion (albeit being dependent on the `minimum` argument).*
+#' These functions are not meant to count isolates, but to calculate the proportion of resistance/susceptibility. Use the [`count_*()`][AMR::count()] functions to count isolates. The function [susceptibility()] is essentially equal to [count_susceptible()]` / `[count_all()]. *Low counts can influence the outcome - the `proportion_*()` functions may camouflage this, since they only return the proportion (albeit dependent on the `minimum` argument).*
 #'
 #' The function [proportion_df()] takes any variable from `data` that has an [`sir`] class (created with [as.sir()]) and calculates the proportions S, I, and R. It also supports grouped variables. The function [sir_df()] works exactly like [proportion_df()], but adds the number of isolates.
 #' @section Combination Therapy:

R/translate.R

@@ -66,17 +66,12 @@
 #' mo_name("Coagulase-negative Staphylococcus (CoNS)")
 #'
 #' # setting another language
-#' set_AMR_locale("Spanish")
+#' set_AMR_locale("Dutch")
 #' ab_name("Ciprofloxacin")
 #' mo_name("Coagulase-negative Staphylococcus (CoNS)")
 #'
 #' # setting yet another language
-#' set_AMR_locale("Greek")
-#' ab_name("Ciprofloxacin")
-#' mo_name("Coagulase-negative Staphylococcus (CoNS)")
-#'
-#' # setting yet another language
-#' set_AMR_locale("Ukrainian")
+#' set_AMR_locale("German")
 #' ab_name("Ciprofloxacin")
 #' mo_name("Coagulase-negative Staphylococcus (CoNS)")
 #'
@@ -266,7 +261,7 @@ translate_into_language <- function(from,
   # a kind of left join to get all results back
   out <- from_unique_translated[match(from.bak, from_unique)]
 
-  if (!identical(from.bak, out) && get_AMR_locale() == lang && message_not_thrown_before("translation", entire_session = TRUE) && interactive()) {
+  if (!identical(from.bak, out) && get_AMR_locale() == lang && is.null(getOption("AMR_locale", default = NULL)) && message_not_thrown_before("translation", entire_session = TRUE) && interactive()) {
     message(word_wrap(
       "Assuming the ", LANGUAGES_SUPPORTED_NAMES[[lang]]$exonym, " language (",
       LANGUAGES_SUPPORTED_NAMES[[lang]]$endonym, ") for the AMR package. See `set_AMR_locale()` to change this or to silence this once-per-session note.",

R/zzz.R

@@ -185,7 +185,7 @@ if (pkg_is_available("cli")) {
     try(loadNamespace("tibble"), silent = TRUE)
   }
 
-  # reference data - they have additional to improve algorithm speed
+  # reference data - they have additional data to improve algorithm speed
   # they cannot be part of R/sysdata.rda since CRAN thinks it would make the package too large (+3 MB)
   AMR_env$AB_lookup <- cbind(AMR::antibiotics, AB_LOOKUP)
   AMR_env$AV_lookup <- cbind(AMR::antivirals, AV_LOOKUP)

_pkgdown.yml

@@ -145,6 +145,12 @@ navbar:
       href: "https://github.com/msberends/AMR"
 
 reference:
+  - title: "Introduction to the package"
+    desc: >
+      Please find the introduction to (and some general information about) our package here.
+    contents:
+    - "`AMR`"
+    
   - title: "Preparing data: microorganisms"
     desc: >
       These functions are meant to get taxonomically valid properties of microorganisms from any input, but
@@ -229,7 +235,6 @@ reference:
       Some pages about our package and its external sources. Be sure to read our [How To's](./../articles/index.html)
       for more information about how to work with functions in this package.
     contents:
-    - "`AMR`"
     - "`example_isolates`"
     - "`microorganisms`"
     - "`microorganisms.codes`"

cran-comments.md

@@ -1,7 +1,9 @@
-The email address of the maintainer has changed - not the person.
+**On the 15th of October, 2023, we received an email from Prof Ripley about an issue in UTF-8 strings in our documentation. This version contains a fix to this issue.**
+
+Previous comments:
 
 As with all previous >20 releases, some CHECKs might return a NOTE for *just* hitting the installation size limit, though its size has been brought down to a minimum in collaboration with CRAN maintainers previously.
 
-We consider this a high-impact package: it was published in the Journal of Statistical Software (2022), is including in a CRAN Task View (Epidemiology), and is according to download stats used in almost all countries in the world. If there is anything to note, please let us know up-front without directly archiving the current version. That said, we continually unit test our package extensively and have no reason to assume that anything is wrong.
+We consider this a high-impact package: it was published in the Journal of Statistical Software (2022), is included in a CRAN Task View (Epidemiology), and is according to download stats used in almost all countries in the world. If there is anything to note, please let us know up-front without directly archiving the current version. That said, we continually unit test our package extensively and have no reason to assume that anything is wrong.
 
 Thanks for maintaining and hosting CRAN! It's empowering R and its use enormously!

data-raw/ab.md5

@@ -1 +1 @@
-8bf97fd5f1d8d82486902d05916ebca0
+3d8c509ec95d61889cae83af43b0e6b7

data-raw/antibiotics.txt

@@ -3,256 +3,256 @@
 "ACM"	6450012	"Acetylmidecamycin"	"Macrolides/lincosamides"	"NA"			""	""					""
 "ASP"	49787020	"Acetylspiramycin"	"Macrolides/lincosamides"	"NA"			""	"acetylspiramycin,foromacidin b,spiramycin ii"					""
 "ALS"	8954	"Aldesulfone sodium"	"Other antibacterials"	"J04BA03"	"Drugs for treatment of lepra"	"Drugs for treatment of lepra"	""	"adesulfone sodium,aldapsone,aldesulfona sodica,aldesulfone,aldesulfone sodique,aldesulfone sodium,aldesulphone sodium,diamidin,diasone,diasone sodium,diazon,novotrone,sodium aldesulphone,sodium sulfoxone,sulfoxone sodium"	0.33	"g"			""
-"AMK"	37768	"Amikacin"	"Aminoglycosides"	"D06AX12,J01GB06,S01AA21"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"ak,ami,amik,amk,an"	"amicacin,amikacillin,amikacin,amikacin base,amikacin dihydrate,amikacin free base,amikacin sulfate,amikacina,amikacine,amikacinum,amikavet,amikin,amiklin,amikozit,amukin,arikace,arikayce liposomal,briclin,kaminax,lukadin,mikavir,pierami,potentox"			1	"g"	"13546-7,15098-7,17798-0,31097-9,31098-7,31099-5,3319-1,3320-9,3321-7,35669-1,50802-8,50803-6,56628-1,59378-0,80972-3"
+"AMK"	37768	"Amikacin"	"Aminoglycosides"	"D06AX12,J01GB06,S01AA21"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"ak,ami,amik,amk,an"	"amicacin,amikacillin,amikacin,amikacin base,amikacin dihydrate,amikacin free base,amikacin sulfate,amikacina,amikacine,amikacinum,amikavet,amikin,amiklin,amikozit,amukin,arikace,arikayce liposomal,briclin,kaminax,lukadin,mikavir,pierami,potentox"			1	"g"	"101493-5,11-7,12-5,13-3,13546-7,14-1,15098-7,17798-0,18860-7,20373-7,23624-0,25174-4,25175-1,25176-9,25177-7,25178-5,25179-3,31097-9,31098-7,31099-5,3319-1,3320-9,3321-7,35669-1,42642-9,48169-7,50802-8,50803-6,56628-1,59378-0,60564-2,60565-9,6975-7,80972-3,89484-0"
 "AKF"		"Amikacin/fosfomycin"	"Aminoglycosides"	"NA"			""	""					""
-"AMX"	33613	"Amoxicillin"	"Beta-lactams/penicillins"	"J01CA04"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"ac,amox,amx"	"actimoxi,amoclen,amolin,amopen,amopenixin,amoxibiotic,amoxicaps,amoxicilina,amoxicillin,amoxicillin hydrate,amoxicilline,amoxicillinum,amoxiden,amoxil,amoxivet,amoxy,amoxycillin,amoxyke,anemolin,aspenil,atoksilin,biomox,bristamox,cemoxin,clamoxyl,damoxy,delacillin,demoksil,dispermox,efpenix,flemoxin,hiconcil,histocillin,hydroxyampicillin,ibiamox,imacillin,lamoxy,largopen,metafarma capsules,metifarma capsules,moksilin,moxacin,moxatag,ospamox,pamoxicillin,piramox,promoxil,remoxil,robamox,sawamox pm,tolodina,topramoxin,unicillin,utimox,vetramox"	1.5	"g"	3	"g"	"16365-9,25274-2,3344-9,80133-2"
+"AMX"	33613	"Amoxicillin"	"Beta-lactams/penicillins"	"J01CA04"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"ac,amox,amx"	"actimoxi,amoclen,amolin,amopen,amopenixin,amoxibiotic,amoxicaps,amoxicilina,amoxicillin,amoxicillin hydrate,amoxicilline,amoxicillinum,amoxiden,amoxil,amoxivet,amoxy,amoxycillin,amoxyke,anemolin,aspenil,atoksilin,biomox,bristamox,cemoxin,clamoxyl,damoxy,delacillin,demoksil,dispermox,efpenix,flemoxin,hiconcil,histocillin,hydroxyampicillin,ibiamox,imacillin,lamoxy,largopen,metafarma capsules,metifarma capsules,moksilin,moxacin,moxatag,ospamox,pamoxicillin,piramox,promoxil,remoxil,robamox,sawamox pm,tolodina,topramoxin,unicillin,utimox,vetramox"	1.5	"g"	3	"g"	"101498-4,15-8,16-6,16365-9,17-4,18-2,18861-5,18862-3,19-0,20-8,21-6,22-4,25274-2,25310-4,3344-9,55614-2,55615-9,55616-7,6976-5,6977-3,80133-2"
 "AMC"	23665637	"Amoxicillin/clavulanic acid"	"Beta-lactams/penicillins"	"J01CR02"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	"a/c,amcl,aml,aug,xl"	"amocla,amoclan,amoclav,amoksiclav,amoxsiklav,amoxyclav,augmentan,augmentin,augmentin xr,augmentine,auspilic,clamentin,clamobit,clavamox,clavinex,clavoxilin plus,clavulin,clavumox,coamoxiclav,eumetinex,kmoxilin,spectramox,spektramox,synulox,viaclav,xiclav"	1.5	"g"	3	"g"	""
-"AXS"	465441	"Amoxicillin/sulbactam"	"Beta-lactams/penicillins"	"NA"			""	""					""
-"AMB"	5280965	"Amphotericin B"	"Antifungals/antimycotics"	"A01AB04,A07AA07,G01AA03,J02AA01"	"Antimycotics for systemic use"	"Antibiotics"	"amf,amfb,amph"	"abelcet,abelecet,ambisome,amfotericina b,amphocin,amphomoronal,amphortericin b,amphotec,amphotericin,amphotericin b,amphotericine b,amphotericinum b,amphozone,anfotericine b,fungilin,fungisome,fungisone,fungizone,halizon"	40	"mg"	35	"mg"	"16370-9,3353-0,3354-8,40707-2,40757-7,49859-2"
+"AXS"	465441	"Amoxicillin/sulbactam"	"Beta-lactams/penicillins"	"NA"			""	""					"55614-2,55615-9,55616-7"
+"AMB"	5280965	"Amphotericin B"	"Antifungals/antimycotics"	"A01AB04,A07AA07,G01AA03,J02AA01"	"Antimycotics for systemic use"	"Antibiotics"	"amf,amfb,amph"	"abelcet,abelecet,ambisome,amfotericina b,amphocin,amphomoronal,amphortericin b,amphotec,amphotericin,amphotericin b,amphotericine b,amphotericinum b,amphozone,anfotericine b,fungilin,fungisome,fungisone,fungizone,halizon"	40	"mg"	35	"mg"	"16370-9,18863-1,23-2,24-0,25-7,26-5,3353-0,3354-8,40707-2,40757-7,49859-2,6978-1"
 "AMH"		"Amphotericin B-high"	"Aminoglycosides"	"NA"			"amfo b high,amhl,ampho b high,amphotericin high"	""					""
-"AMP"	6249	"Ampicillin"	"Beta-lactams/penicillins"	"J01CA01,S01AA19"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"am,amp,ampi"	"acillin,adobacillin,amblosin,amcill,amfipen,amfipen v,amipenix s,ampichel,ampicil,ampicilina,ampicillin,ampicillin a,ampicillin acid,ampicillin anhydrate,ampicillin anhydrous,ampicillin base,ampicillin hydrate,ampicillin sodium,ampicillina,ampicilline,ampicillinum,ampicin,ampifarm,ampikel,ampimed,ampipenin,ampiscel,ampisyn,ampivax,ampivet,amplacilina,amplin,amplipenyl,amplisom,amplital,anhydrous ampicillin,austrapen,binotal,bonapicillin,britacil,campicillin,copharcilin,delcillin,deripen,divercillin,doktacillin,duphacillin,grampenil,guicitrina,guicitrine,lifeampil,marcillin,morepen,norobrittin,nuvapen,olin kid,omnipen,orbicilina,pen a oral,pen ampil,penbristol,penbritin,penbritin paediatric,penbritin syrup,penbrock,penicline,penimic,pensyn,pentrex,pentrexl,pentrexyl,pentritin,pfizerpen a,polycillin,polyflex,ponecil,princillin,principen,qidamp,racenacillin,redicilin,rosampline,roscillin,semicillin,semicillin r,servicillin,sumipanto,synpenin,texcillin,tokiocillin,tolomol,totacillin,totalciclina,totapen,trifacilina,ukapen,ultrabion,ultrabron,vampen,viccillin,viccillin s,vidocillin,wypicil"	2	"g"	6	"g"	"21066-6,3355-5,33562-0,33919-2,43883-8,43884-6,87604-5"
-"SAM"	119561	"Ampicillin/sulbactam"	"Beta-lactams/penicillins"	"J01CR01"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	"a/s,ab,ams,amsu,apsu,sam"	"sulacillin"			6	"g"	""
+"AMP"	6249	"Ampicillin"	"Beta-lactams/penicillins"	"J01CA01,S01AA19"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"am,amp,ampi"	"acillin,adobacillin,amblosin,amcill,amfipen,amfipen v,amipenix s,ampichel,ampicil,ampicilina,ampicillin,ampicillin a,ampicillin acid,ampicillin anhydrate,ampicillin anhydrous,ampicillin base,ampicillin hydrate,ampicillin sodium,ampicillina,ampicilline,ampicillinum,ampicin,ampifarm,ampikel,ampimed,ampipenin,ampiscel,ampisyn,ampivax,ampivet,amplacilina,amplin,amplipenyl,amplisom,amplital,anhydrous ampicillin,austrapen,binotal,bonapicillin,britacil,campicillin,copharcilin,delcillin,deripen,divercillin,doktacillin,duphacillin,grampenil,guicitrina,guicitrine,lifeampil,marcillin,morepen,norobrittin,nuvapen,olin kid,omnipen,orbicilina,pen a oral,pen ampil,penbristol,penbritin,penbritin paediatric,penbritin syrup,penbrock,penicline,penimic,pensyn,pentrex,pentrexl,pentrexyl,pentritin,pfizerpen a,polycillin,polyflex,ponecil,princillin,principen,qidamp,racenacillin,redicilin,rosampline,roscillin,semicillin,semicillin r,servicillin,sumipanto,synpenin,texcillin,tokiocillin,tolomol,totacillin,totalciclina,totapen,trifacilina,ukapen,ultrabion,ultrabron,vampen,viccillin,viccillin s,vidocillin,wypicil"	2	"g"	6	"g"	"101477-8,101478-6,18864-9,18865-6,20374-5,21066-6,23618-2,27-3,28-1,29-9,30-7,31-5,32-3,33-1,3355-5,33562-0,33919-2,34-9,43883-8,43884-6,6979-9,6980-7,87604-5"
+"SAM"	119561	"Ampicillin/sulbactam"	"Beta-lactams/penicillins"	"J01CR01"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	"a/s,ab,ams,amsu,apsu,sam"	"sulacillin"			6	"g"	"101478-6,18865-6,20374-5,23618-2,31-5,32-3,33-1,34-9,6980-7"
 "AMR"	73341	"Amprolium"	"Other antibacterials"	"NA"			""	"amprocidum,amprol,amprolio,amprolium,amprolium chloride,amprovine,thiacoccid"					""
-"ANI"	166548	"Anidulafungin"	"Antifungals/antimycotics"	"J02AX06"	"Antimycotics for systemic use"	"Other antimycotics for systemic use"	"anid"	"anidulafungin,anidulafungina,anidulafungine,anidulafunginum,ecalta,eraxis"			0.1	"g"	"58420-1"
+"ANI"	166548	"Anidulafungin"	"Antifungals/antimycotics"	"J02AX06"	"Antimycotics for systemic use"	"Other antimycotics for systemic use"	"anid"	"anidulafungin,anidulafungina,anidulafungine,anidulafunginum,ecalta,eraxis"			0.1	"g"	"55343-8,57095-2,58420-1,77162-6"
 "APL"	6602341	"Apalcillin"	"Beta-lactams/penicillins"	"NA"			""	"apalcilina,apalcillin,apalcilline,apalcillinum"					""
-"APR"	3081545	"Apramycin"	"Aminoglycosides"	"NA"			""	"ambylan,apralan,apramicina,apramycin,apramycine,apramycinum,nebramycin ii"					""
-"ARB"	68682	"Arbekacin"	"Aminoglycosides"	"J01GB12"			""	"arbekacin,arbekacina,arbekacine,arbekacini sulfas,arbekacinum,habekacin,haberacin"			0.2	"g"	""
+"APR"	3081545	"Apramycin"	"Aminoglycosides"	"NA"			""	"ambylan,apralan,apramicina,apramycin,apramycine,apramycinum,nebramycin ii"					"23659-6,73652-0,73653-8"
+"ARB"	68682	"Arbekacin"	"Aminoglycosides"	"J01GB12"			""	"arbekacin,arbekacina,arbekacine,arbekacini sulfas,arbekacinum,habekacin,haberacin"			0.2	"g"	"32373-3,53818-1,54173-0"
 "APX"	71961	"Aspoxicillin"	"Beta-lactams/penicillins"	"J01CA19"			""	"aspoxicilina,aspoxicillan,aspoxicillin,aspoxicilline,aspoxicillinum"			4	"g"	""
 "AST"	5284517	"Astromicin"	"Aminoglycosides"	"NA"			""	"astromicin,astromicin a,astromicina,astromicine,astromicinum,fortimicin,fortimicin a"					""
 "AVB"	9835049	"Avibactam"	"Beta-lactams/penicillins"	"NA"			""	"avibactam,avibactam free acid,avibactamfreeacid"					""
-"AVI"	71674	"Avilamycin"	"Other antibacterials"	"NA"			""	"avilamycin,avilamycina,avilamycine,avilamycinum,surmax"					""
+"AVI"	71674	"Avilamycin"	"Other antibacterials"	"NA"			""	"avilamycin,avilamycina,avilamycine,avilamycinum,surmax"					"35754-1,35755-8,35756-6,55619-1"
 "AVO"	16131159	"Avoparcin"	"Glycopeptides"	"NA"			""	"avoparcin,avoparcina,avoparcine,avoparcinum,avotan"					""
 "AZD"	15574941	"Azidocillin"	"Beta-lactams/penicillins"	"J01CE04"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	""	"azidocilina,azidocillin,azidocillina,azidocilline,azidocillinum"	1.5	"g"			""
-"AZM"	447043	"Azithromycin"	"Macrolides/lincosamides"	"J01FA10,S01AA26"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"az,azi,azit,azm"	"aritromicina,aruzilina,azasite,azenil,azifast,azigram,azimakrol,azithramycine,azithrocin,azithromycin,azithromycine,azithromycinum,azitrocin,azitromax,azitromicina,azitromicine,azitromin,aziwin,aziwok,aztrin,azyter,azythromycin,durasite,hemomycin,macrozit,misultina,mixoterin,setron,sumamed,toraseptol,tromix,trozocina,trulimax,xithrone,zentavion,zithrax,zithromac,zithromax,zithromax iv,zithromycin,zitrim,zitromax,zitrotek,zmax sr,zythromax"	0.3	"g"	0.5	"g"	"16420-2,25233-8"
+"AZM"	447043	"Azithromycin"	"Macrolides/lincosamides"	"J01FA10,S01AA26"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"az,azi,azit,azm"	"aritromicina,aruzilina,azasite,azenil,azifast,azigram,azimakrol,azithramycine,azithrocin,azithromycin,azithromycine,azithromycinum,azitrocin,azitromax,azitromicina,azitromicine,azitromin,aziwin,aziwok,aztrin,azyter,azythromycin,durasite,hemomycin,macrozit,misultina,mixoterin,setron,sumamed,toraseptol,tromix,trozocina,trulimax,xithrone,zentavion,zithrax,zithromac,zithromax,zithromax iv,zithromycin,zitrim,zitromax,zitrotek,zmax sr,zythromax"	0.3	"g"	0.5	"g"	"100043-9,16420-2,16421-0,18866-4,23612-5,25233-8,35-6,36-4,37-2,38-0,6981-5,89480-8"
 "AFC"		"Azithromycin/fluconazole/secnidazole"	"Other antibacterials"	"J01RA07"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
-"AZL"	6479523	"Azlocillin"	"Beta-lactams/penicillins"	"J01CA09"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"az,azl,azlo"	"azlocilina,azlocillin,azlocilline,azlocillinum"			12	"g"	""
-"ATM"	5742832	"Aztreonam"	"Beta-lactams/penicillins"	"J01DF01"	"Other beta-lactam antibacterials"	"Monobactams"	"at,atm,azm,azt,aztr"	"azactam,azetreonam,azonam,azthreonam,aztreon,aztreonam,nebactam,primbactam"			4	"g"	"16423-6,25234-6,3369-6"
+"AZL"	6479523	"Azlocillin"	"Beta-lactams/penicillins"	"J01CA09"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"az,azl,azlo"	"azlocilina,azlocillin,azlocilline,azlocillinum"			12	"g"	"16422-8,18867-2,3368-8,39-8,40-6,41-4,41661-0,42-2"
+"ATM"	5742832	"Aztreonam"	"Beta-lactams/penicillins"	"J01DF01"	"Other beta-lactam antibacterials"	"Monobactams"	"at,atm,azm,azt,aztr"	"azactam,azetreonam,azonam,azthreonam,aztreon,aztreonam,nebactam,primbactam"			4	"g"	"101497-6,16423-6,18868-0,25234-6,3369-6,41662-8,41663-6,41664-4,41727-9,43-0,44-8,45-5,46-3,6982-3"
 "AZA"		"Aztreonam/avibactam"	"Beta-lactams/penicillins"	"NA"			""	""					""
 "ANC"		"Aztreonam/nacubactam"	"Beta-lactams/penicillins"	"NA"			""	""					""
-"BAM"	441397	"Bacampicillin"	"Beta-lactams/penicillins"	"J01CA06"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"bacampicilina,bacampicillin,bacampicilline,bacampicillinum,penglobe"	1.2	"g"			""
-"BAC"	78358334	"Bacitracin"	"Other antibacterials"	"R02AB04,J01XX10"			"baci"	"fortracin,md bacitracin"					""
-"BDQ"	5388906	"Bedaquiline"	"Other antibacterials"	"J04AK05"			""	"bedaquiline,sirturo"	86	"mg"			"80637-2"
+"BAM"	441397	"Bacampicillin"	"Beta-lactams/penicillins"	"J01CA06"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"bacampicilina,bacampicillin,bacampicilline,bacampicillinum,penglobe"	1.2	"g"			"18869-8,47-1,48-9,49-7,50-5,55620-9"
+"BAC"	78358334	"Bacitracin"	"Other antibacterials"	"R02AB04,J01XX10"			"baci"	"fortracin,md bacitracin"					"10868-8,16428-5,18870-6,6827-0,6983-1,87603-7"
+"BDQ"	5388906	"Bedaquiline"	"Other antibacterials"	"J04AK05"			""	"bedaquiline,sirturo"	86	"mg"			"80637-2,88703-4,88704-2,94274-8,96107-8"
 "BEK"	439318	"Bekanamycin"	"Aminoglycosides"	"J01GB13"			""	"aminodeoxykanamycin,becanamicina,bekanamycin,bekanamycine,bekanamycinum,kanamycin b,klebcil,nebramycin v"			0.6	"g"	""
 "BNB"		"Benzathine benzylpenicillin"	"Beta-lactams/penicillins"	"J01CE08"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	""	"beacillin,cepacilina,extencilline,lentopenil,penidural,tardocillin"			3.6	"g"	""
 "BNP"	64725	"Benzathine phenoxymethylpenicillin"	"Beta-lactams/penicillins"	"J01CE10"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	""	"bicillin v,biphecillin"	2	"g"			""
 "PEN"	5904	"Benzylpenicillin"	"Beta-lactams/penicillins"	"J01CE01,S01AA14"	"Combinations of antibacterials"	"Combinations of antibacterials"	"bepe,pen,peni,peni g,penicillin,penicillin g,pg"	"abbocillin,ayercillin,bencilpenicilina,benzopenicillin,benzyl penicillin,benzylpenicillin,benzylpenicillin g,benzylpenicilline,benzylpenicillinum,bicillin,cillora,cilloral,cilopen,compocillin g,cosmopen,dropcillin,free penicillin g,free penicillin ii,galofak,gelacillin,liquacillin,megacillin,pencillin g,penicillin,penicilling,pentids,permapen,pfizerpen,pfizerpen g,pharmacillin,pradupen,specilline g,ursopen"			3.6	"g"	""
-"BES"	10178705	"Besifloxacin"	"Quinolones"	"S01AE08"			""	"besifloxacin,besivance"					""
-"BIA"	71339	"Biapenem"	"Carbapenems"	"J01DH05"			""	"biapenem,biapenern,bipenem,omegacin"			1.2	"g"	""
+"BES"	10178705	"Besifloxacin"	"Quinolones"	"S01AE08"			""	"besifloxacin,besivance"					"73606-6,73628-0,73651-2"
+"BIA"	71339	"Biapenem"	"Carbapenems"	"J01DH05"			""	"biapenem,biapenern,bipenem,omegacin"			1.2	"g"	"41665-1,41666-9,41667-7,41728-7"
 "BCZ"	65807	"Bicyclomycin"	"Other antibacterials"	"NA"			"bicozamycin"	"aizumycin,bacfeed,bacteron,bicozamicina,bicozamycin,bicozamycine,bicozamycinum,bicyclomycin"					""
 "BDP"	68760	"Brodimoprim"	"Trimethoprims"	"J01EA02"	"Sulfonamides and trimethoprim"	"Trimethoprim and derivatives"	""	"brodimoprim,brodimoprima,brodimoprime,brodimoprimum,bromdimoprim,hyprim,unitrim"	0.2	"g"			""
 "BUT"	47472	"Butoconazole"	"Antifungals/antimycotics"	"G01AF15"			""	"butaconazole,butoconazol,butoconazole,butoconazolum,compositenstarke,dahlin,femstat,gynofort,polyfructosanum"					""
 "CDZ"	44242317	"Cadazolid"	"Oxazolidinones"	"NA"			""	"cadazolid"					""
 "CLA"		"Calcium aminosalicylate"	"Antimycobacterials"	"J04AA03"	"Drugs for treatment of tuberculosis"	"Aminosalicylic acid and derivatives"	""	""	15	"g"			""
-"CAP"	135565060	"Capreomycin"	"Antimycobacterials"	"J04AB30"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"capr"	""			1	"g"	""
-"CRB"	20824	"Carbenicillin"	"Beta-lactams/penicillins"	"J01CA03"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"bar,carb,cb"	"anabactyl,carbenicilina,carbenicillin,carbenicillina,carbenicilline,carbenicillinum,geopen,pyopen"			12	"g"	"3434-8"
+"CAP"	135565060	"Capreomycin"	"Antimycobacterials"	"J04AB30"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"capr"	""			1	"g"	"16545-6,18872-2,23607-5,25210-6,25211-4,25212-2,42643-7,48170-5,55-4,55623-3,56-2,57-0,58-8,61355-4,89483-2"
+"CRB"	20824	"Carbenicillin"	"Beta-lactams/penicillins"	"J01CA03"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"bar,carb,cb"	"anabactyl,carbenicilina,carbenicillin,carbenicillina,carbenicilline,carbenicillinum,geopen,pyopen"			12	"g"	"18873-0,3434-8,41668-5,59-6,60-4,61-2,62-0"
 "CRN"	93184	"Carindacillin"	"Beta-lactams/penicillins"	"J01CA05"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"carindacilina,carindacillin,carindacilline,carindacillinum"	4	"g"			""
-"CAR"	6540466	"Carumonam"	"Other antibacterials"	"J01DF02"			""	"carumonam,carumonamum"			2	"g"	""
-"CAS"	2826718	"Caspofungin"	"Antifungals/antimycotics"	"J02AX04"	"Antimycotics for systemic use"	"Other antimycotics for systemic use"	"casp"	"cancidas,capsofungin,caspofungin"			50	"mg"	"58419-3"
-"CAC"	91562	"Cefacetrile"	"Cephalosporins (1st gen.)"	"J01DB10"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"cefacetril,cefacetrile,cefacetrilo,cefacetrilum,celospor,celtol,cephacetrile,cristacef,vetrimast"					""
-"CEC"	51039	"Cefaclor"	"Cephalosporins (2nd gen.)"	"J01DC04"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"ccl,cec,cf,cfac,cfc,cfcl,cfr,fac"	"alenfral,alfacet,ceclor,ceclor cd,cefaclor,cefaclor anhydrous,cefaclor impurity c,cefaclor monohydrate,cefaclorimpurityc,cefacloro,cefaclorum,cefeaclor,cephaclor,dystaclor mr,keflor,kefral,panoral,raniclor"	1	"g"			"16564-7,21149-0"
-"CFR"	47965	"Cefadroxil"	"Cephalosporins (1st gen.)"	"J01DB05"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfdx,cfr,fad"	"anhydrous cefadroxil,cefadrops,cefadroxil,cefadroxil anhydrous,cefadroxilo,cefadroxilum,cefradroxil,cephadroxil,duracef,duricef,sumacef,ultracef"	2	"g"			"16565-4"
+"CAR"	6540466	"Carumonam"	"Other antibacterials"	"J01DF02"			""	"carumonam,carumonamum"			2	"g"	"51694-8"
+"CAS"	2826718	"Caspofungin"	"Antifungals/antimycotics"	"J02AX04"	"Antimycotics for systemic use"	"Other antimycotics for systemic use"	"casp"	"cancidas,capsofungin,caspofungin"			50	"mg"	"32378-2,54175-5,54176-3,54185-4,58419-3"
+"CAC"	91562	"Cefacetrile"	"Cephalosporins (1st gen.)"	"J01DB10"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"cefacetril,cefacetrile,cefacetrilo,cefacetrilum,celospor,celtol,cephacetrile,cristacef,vetrimast"					"55624-1,55625-8,55626-6,55627-4"
+"CEC"	51039	"Cefaclor"	"Cephalosporins (2nd gen.)"	"J01DC04"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"ccl,cec,cf,cfac,cfc,cfcl,cfr,fac"	"alenfral,alfacet,ceclor,ceclor cd,cefaclor,cefaclor anhydrous,cefaclor impurity c,cefaclor monohydrate,cefaclorimpurityc,cefacloro,cefaclorum,cefeaclor,cephaclor,dystaclor mr,keflor,kefral,panoral,raniclor"	1	"g"			"16564-7,18874-8,21149-0,6986-4,83-6,84-4,85-1,86-9"
+"CFR"	47965	"Cefadroxil"	"Cephalosporins (1st gen.)"	"J01DB05"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfdx,cfr,fad"	"anhydrous cefadroxil,cefadrops,cefadroxil,cefadroxil anhydrous,cefadroxilo,cefadroxilum,cefradroxil,cephadroxil,duracef,duricef,sumacef,ultracef"	2	"g"			"16565-4,18875-5,55628-2,63-8,64-6,65-3,66-1"
 "LEX"	27447	"Cefalexin"	"Cephalosporins (1st gen.)"	"J01DB01"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cflx"	"alcephin,alexin,alsporin,amplex,anhydrous cefalexin,anhydrous cephalexin,biocef,carnosporin,cefablan,cefadal,cefadin,cefadina,cefaleksin,cefalessina,cefalexin,cefalexin anhydrous,cefalexina,cefalexine,cefalexinum,cefalin,cefaloto,cefaseptin,ceffanex,ceflax,ceforal,cefovit,celexin,cepastar,cepexin,cephacillin,cephalexin,cephalexin anhydrous,cephalexine,cephalexinum,cephanasten,cephaxin,cephin,ceporex,ceporex forte,ceporexin,ceporexine,cerexin,cerexins,cophalexin,durantel,durantel ds,erocetin,factagard,felexin,ibilex,ibrexin,inphalex,kefalospes,keflet,keflex,kefolan,keforal,keftab,kekrinal,kidolex,lafarine,larixin,lenocef,lexibiotico,lonflex,lopilexin,madlexin,mamalexin,mamlexin,medoxine,neokef,neolexina,novolexin,optocef,oracef,oriphex,oroxin,ortisporina,ospexin,palitrex,panixine disperdose,pectril,pyassan,roceph,roceph distab,sanaxin,sartosona,sencephalin,sepexin,servispor,sialexin,sinthecillin,sporicef,sporidex,syncle,synecl,tepaxin,tokiolexin,uphalexin,voxxim,winlex,zozarine"	2	"g"			""
 "RID"	5773	"Cefaloridine"	"Cephalosporins (1st gen.)"	"J01DB02"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cefa"	"aliporina,ampligram,cefaloridin,cefaloridina,cefaloridine,cefaloridinum,cefalorizin,ceflorin,cepaloridin,cepalorin,cephalomycine,cephaloridin,cephaloridine,cephaloridinum,ceporan,ceporin,ceporine,cilifor,deflorin,faredina,floridin,glaxoridin,intrasporin,keflodin,keflordin,kefloridin,kefspor,lloncefal,loridine,sasperin,sefacin,verolgin,vioviantine"			3	"g"	""
 "CEP"	6024	"Cefalotin"	"Cephalosporins (1st gen.)"	"J01DB03"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfal,cflt"	"cefalothin,cefalotin,cefalotina,cefalotina fabra,cefalotine,cefalotinum,cemastin,cephalothinum,cephalotin,cephalotin acid,coaxin,keflin,seffin"			4	"g"	""
-"MAN"	456255	"Cefamandole"	"Cephalosporins (2nd gen.)"	"J01DC03"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cfam,cfmn"	"cefadole,cefamandol,cefamandole,cefamandolum,cephadole,cephamandole,kefamandol,kefdole,mancef"			6	"g"	"3441-3"
+"MAN"	456255	"Cefamandole"	"Cephalosporins (2nd gen.)"	"J01DC03"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cfam,cfmn"	"cefadole,cefamandol,cefamandole,cefamandolum,cephadole,cephamandole,kefamandol,kefdole,mancef"			6	"g"	"18876-3,3441-3,41669-3,55634-0,55635-7,55636-5,55637-3,67-9,68-7,69-5,70-3"
 "HAP"	30699	"Cefapirin"	"Cephalosporins (1st gen.)"	"J01DB08"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"ambrocef,cefadyl,cefapilin,cefapirin,cefapirina,cefapirine,cefapirinum,cefaprin,cefaprin sodium,cefatrex,cefatrexyl,cephapirine,metricure"			4	"g"	""
-"CTZ"	6410758	"Cefatrizine"	"Cephalosporins (1st gen.)"	"J01DB07"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"bricef,cefatrix,cefatrizine,cefatrizino,cefatrizinum,cephatriazine,cepticol,cetrazil,latocef,orosporina,trizina"	1	"g"			""
+"CTZ"	6410758	"Cefatrizine"	"Cephalosporins (1st gen.)"	"J01DB07"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"bricef,cefatrix,cefatrizine,cefatrizino,cefatrizinum,cephatriazine,cepticol,cetrazil,latocef,orosporina,trizina"	1	"g"			"18877-1,55639-9,71-1,72-9,73-7,74-5"
 "CZD"	71736	"Cefazedone"	"Cephalosporins (1st gen.)"	"J01DB06"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"cefazedon,cefazedona,cefazedone,cefazedone acid,cefazedonum,refosporen,refosporene,refosporin"			3	"g"	""
-"CZO"	33255	"Cefazolin"	"Cephalosporins (1st gen.)"	"J01DB04"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfz,cfzl,cz,czol,faz,kz"	"atirin,cefamezin,cefamezine,cefazina,cefazolin,cefazolin acid,cefazolina,cefazoline,cefazolinum,cephamezine,cephazolidin,cephazolin,cephazoline,elzogram,firmacef,kefzol,liviclina,totacef"			3	"g"	"16566-2,25235-3,3442-1,3443-9,80962-4"
+"CZO"	33255	"Cefazolin"	"Cephalosporins (1st gen.)"	"J01DB04"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfz,cfzl,cz,czol,faz,kz"	"atirin,cefamezin,cefamezine,cefazina,cefazolin,cefazolin acid,cefazolina,cefazoline,cefazolinum,cephamezine,cephazolidin,cephazolin,cephazoline,elzogram,firmacef,kefzol,liviclina,totacef"			3	"g"	"16566-2,18878-9,25235-3,3442-1,3443-9,41670-1,75-2,76-0,77-8,78-6,80962-4,85422-4"
 "CFB"	127527	"Cefbuperazone"	"Other antibacterials"	"J01DC13"			""	"cefbuperazona,cefbuperazone,cefbuperazonum,cefbuperzaone,cerbuperazone,tomiporan"			2	"g"	""
-"CCP"	6436055	"Cefcapene"	"Cephalosporins (3rd gen.)"	"J01DD17"			""	"cefcamate,cefcapene"	0.45	"g"			""
+"CCP"	6436055	"Cefcapene"	"Cephalosporins (3rd gen.)"	"J01DD17"			""	"cefcamate,cefcapene"	0.45	"g"			"100044-7,76143-7"
 "CCX"	5282438	"Cefcapene pivoxil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefcamate pivoxil,cefcapene piroxil"					""
-"CDR"	6915944	"Cefdinir"	"Cephalosporins (3rd gen.)"	"J01DD15"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cd,cdn,cdr,cfd,din"	"cefdinir,cefdinir anhydrous,cefdinirum,cefdinyl,cefdirnir,ceftinex,cefzon,omnicef"	0.6	"g"			""
-"DIT"	9870843	"Cefditoren"	"Cephalosporins (3rd gen.)"	"J01DD16"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cdn"	"cefditoren"	0.4	"g"			""
+"CDR"	6915944	"Cefdinir"	"Cephalosporins (3rd gen.)"	"J01DD15"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cd,cdn,cdr,cfd,din"	"cefdinir,cefdinir anhydrous,cefdinirum,cefdinyl,cefdirnir,ceftinex,cefzon,omnicef"	0.6	"g"			"23636-4,23637-2,35757-4,35758-2"
+"DIT"	9870843	"Cefditoren"	"Cephalosporins (3rd gen.)"	"J01DD16"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cdn"	"cefditoren"	0.4	"g"			"35759-0,35760-8,35761-6,35762-4"
 "DIX"	6437877	"Cefditoren pivoxil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefditoren,cefditoren pi voxil,cefditoren pivoxil,cefditorin,cefditorin pivoxil,meiact,spectracef"					""
-"FEP"	5479537	"Cefepime"	"Cephalosporins (4th gen.)"	"J01DE01"	"Other beta-lactam antibacterials"	"Fourth-generation cephalosporins"	"cfep,cfpi,cpe,cpm,fep,pm,xpm"	"axepim,cefepima,cefepime,cefepimum,cepimax,cepimex,maxcef,maxipime"			4	"g"	"38363-8"
+"FEP"	5479537	"Cefepime"	"Cephalosporins (4th gen.)"	"J01DE01"	"Other beta-lactam antibacterials"	"Fourth-generation cephalosporins"	"cfep,cfpi,cpe,cpm,fep,pm,xpm"	"axepim,cefepima,cefepime,cefepimum,cepimax,cepimex,maxcef,maxipime"			4	"g"	"101502-3,18879-7,31142-3,31143-1,35763-2,38363-8,42350-9,42351-7,42353-3,50631-1,58412-8,6643-1,6644-9,6645-7,6646-5,6987-2,8272-7,8273-5"
 "CFA"		"Cefepime/amikacin"	"Other antibacterials"	"J01RA06"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "CPC"	9567559	"Cefepime/clavulanic acid"	"Cephalosporins (4th gen.)"	"NA"			"cicl,xpml"	""					""
 "FNC"		"Cefepime/nacubactam"	"Beta-lactams/penicillins"	"NA"			""	""					""
 "FPT"	9567558	"Cefepime/tazobactam"	"Cephalosporins (4th gen.)"	"NA"			""	""					""
 "FPZ"		"Cefepime/zidebactam"	"Other antibacterials"	"NA"			""	""					""
-"CAT"	5487888	"Cefetamet"	"Cephalosporins (3rd gen.)"	"J01DD10"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	"cefetamet,cefetametum,cepime o,deacetoxycefotaxime"	1	"g"			""
+"CAT"	5487888	"Cefetamet"	"Cephalosporins (3rd gen.)"	"J01DD10"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	"cefetamet,cefetametum,cepime o,deacetoxycefotaxime"	1	"g"			"32377-4,35764-0,35765-7,55640-7"
 "CPI"	5486182	"Cefetamet pivoxil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefetamet pivoxyl,globocef"					""
 "CCL"	71719688	"Cefetecol"	"Cephalosporins (4th gen.)"	"NA"			"cefcatacol"	"cefetecol,cefetecol anhydrous"					""
 "CZL"	193956	"Cefetrizole"	"Cephalosporins (unclassified gen.)"	"NA"			""	"cefetrizole,cefetrizolum"					""
-"FDC"	77843966	"Cefiderocol"	"Other antibacterials"	"J01DI04"			""	"cefiderocol"					""
-"CFM"	5362065	"Cefixime"	"Cephalosporins (3rd gen.)"	"J01DD08"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfe,cfix,cfxm,dcfm,fix,ix"	"anhydrous cefixime,cefixim,cefixima,cefixime,cefixime anhydrous,cefixime hydrate,cefiximum,cefixoral,cefspan,cephoral,citropen,denvar,necopen,oroken,suprax,tricef,unixime"	0.4	"g"			"16567-0,25236-1"
+"FDC"	77843966	"Cefiderocol"	"Other antibacterials"	"J01DI04"			""	"cefiderocol"					"95767-0,99280-0,99503-5"
+"CFM"	5362065	"Cefixime"	"Cephalosporins (3rd gen.)"	"J01DD08"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfe,cfix,cfxm,dcfm,fix,ix"	"anhydrous cefixime,cefixim,cefixima,cefixime,cefixime anhydrous,cefixime hydrate,cefiximum,cefixoral,cefspan,cephoral,citropen,denvar,necopen,oroken,suprax,tricef,unixime"	0.4	"g"			"16567-0,18880-5,25236-1,35766-5,79-4,80-2,81-0,82-8"
 "CEO"		"Cefixime/ornidazole"	"Other antibacterials"	"J01RA15"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
-"CMX"	9570757	"Cefmenoxime"	"Cephalosporins (3rd gen.)"	"J01DD05"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	"bestron,cefmax,cefmenoxima,cefmenoxime,cefmenoximum"			2	"g"	""
-"CMZ"	42008	"Cefmetazole"	"Cephalosporins (2nd gen.)"	"J01DC09"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	""	"cefmetazole,cefmetazolesodium,cefmetazolo,cefmetazolum"			4	"g"	""
-"CNX"	71141	"Cefminox"	"Other antibacterials"	"J01DC12"			""	"cefminox,cefminoxum"			4	"g"	""
-"DIZ"	5361871	"Cefodizime"	"Cephalosporins (3rd gen.)"	"J01DD09"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	"cefodizima,cefodizime,cefodizime acid,cefodizime disodium,cefodizimum,cefodizme,diezime,modivid,neucef,timecef"			2	"g"	""
-"CID"	43594	"Cefonicid"	"Cephalosporins (2nd gen.)"	"J01DC06"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	""	"cefonicid,cefonicido,cefonicidum,monocef"			1	"g"	"25237-9,3444-7"
-"CFP"	44187	"Cefoperazone"	"Cephalosporins (3rd gen.)"	"J01DD12"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfp,cfpz,cp,cpz,fop,per"	"bioperazone,cefobid,cefoperazine,cefoperazon,cefoperazone,cefoperazone acid,cefoperazono,cefoperazonum,cefozon,medocef,myticef,pathozone,peracef"			4	"g"	"3445-4"
-"CSL"		"Cefoperazone/sulbactam"	"Cephalosporins (3rd gen.)"	"J01DD62"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	""			4	"g"	""
-"CND"	43507	"Ceforanide"	"Cephalosporins (2nd gen.)"	"J01DC11"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	""	"ceforanide,ceforanido,ceforanidum,precef,radacef"			4	"g"	""
+"CMX"	9570757	"Cefmenoxime"	"Cephalosporins (3rd gen.)"	"J01DD05"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	"bestron,cefmax,cefmenoxima,cefmenoxime,cefmenoximum"			2	"g"	"32375-8,54174-8,54203-5,55641-5"
+"CMZ"	42008	"Cefmetazole"	"Cephalosporins (2nd gen.)"	"J01DC09"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	""	"cefmetazole,cefmetazolesodium,cefmetazolo,cefmetazolum"			4	"g"	"11575-8,18881-3,25222-1,87-7,88-5,89-3,90-1"
+"CNX"	71141	"Cefminox"	"Other antibacterials"	"J01DC12"			""	"cefminox,cefminoxum"			4	"g"	"54908-9"
+"DIZ"	5361871	"Cefodizime"	"Cephalosporins (3rd gen.)"	"J01DD09"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	"cefodizima,cefodizime,cefodizime acid,cefodizime disodium,cefodizimum,cefodizme,diezime,modivid,neucef,timecef"			2	"g"	"18882-1,6988-0,91-9,92-7,93-5,94-3"
+"CID"	43594	"Cefonicid"	"Cephalosporins (2nd gen.)"	"J01DC06"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	""	"cefonicid,cefonicido,cefonicidum,monocef"			1	"g"	"18883-9,25237-9,3444-7,55642-3,95-0,96-8,97-6,98-4"
+"CFP"	44187	"Cefoperazone"	"Cephalosporins (3rd gen.)"	"J01DD12"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfp,cfpz,cp,cpz,fop,per"	"bioperazone,cefobid,cefoperazine,cefoperazon,cefoperazone,cefoperazone acid,cefoperazono,cefoperazonum,cefozon,medocef,myticef,pathozone,peracef"			4	"g"	"100-8,101-6,102-4,18884-7,3445-4,35767-3,35768-1,54166-4,54167-2,54168-0,99-2"
+"CSL"		"Cefoperazone/sulbactam"	"Cephalosporins (3rd gen.)"	"J01DD62"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	""			4	"g"	"35768-1,54166-4,54167-2,54168-0"
+"CND"	43507	"Ceforanide"	"Cephalosporins (2nd gen.)"	"J01DC11"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	""	"ceforanide,ceforanido,ceforanidum,precef,radacef"			4	"g"	"103-2,104-0,105-7,106-5,18885-4,55643-1"
 "CSE"	9830519	"Cefoselis"	"Cephalosporins (4th gen.)"	"NA"			""	"cefoselis,cefoselis sulfate,wincef,winsef"					""
-"CTX"	5742673	"Cefotaxime"	"Cephalosporins (3rd gen.)"	"J01DD01"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfot,cft,cftx,ct,ctx,fot,tax,xct"	"cefotaxim,cefotaxim hikma,cefotaxima,cefotaxima acid,cefotaxime,cefotaxime acid,cefotaximum,cephotaxime,claforan,omnatax"			4	"g"	"25238-7,3446-2,80961-6"
+"CTX"	5742673	"Cefotaxime"	"Cephalosporins (3rd gen.)"	"J01DD01"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfot,cft,cftx,ct,ctx,fot,tax,xct"	"cefotaxim,cefotaxim hikma,cefotaxima,cefotaxima acid,cefotaxime,cefotaxime acid,cefotaximum,cephotaxime,claforan,omnatax"			4	"g"	"101479-4,101480-2,107-3,108-1,109-9,110-7,18886-2,25238-7,31138-1,31139-9,3446-2,35769-9,35770-7,35771-5,41671-9,50632-9,52128-6,54191-2,54192-0,54193-8,55189-5,55644-9,6989-8,80961-6"
 "CTC"	9575353	"Cefotaxime/clavulanic acid"	"Cephalosporins (3rd gen.)"	"NA,J01DD51"			"cxcl,xctl"	""					""
-"CTS"	9574753	"Cefotaxime/sulbactam"	"Cephalosporins (3rd gen.)"	"NA"			""	""					""
-"CTT"	53025	"Cefotetan"	"Cephalosporins (2nd gen.)"	"J01DC05"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cftt,cn,cte,ctn,ctt,tans"	"apacef,cefotan,cefotetan,cefotetan acid,cefotetan free acid,cefotetanum"			4	"g"	"25239-5,3447-0"
-"CTF"	43708	"Cefotiam"	"Cephalosporins (2nd gen.)"	"J01DC07"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	""	"cefotiam,cefotiam?,cefotiamum,ceradolan,ceradon,haloapor"	1.2	"g"	4	"g"	""
-"CHE"	125846	"Cefotiam hexetil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefotiam cilexetil,pansporin t"					""
-"FOV"	9578573	"Cefovecin"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefovecin"					""
-"FOX"	441199	"Cefoxitin"	"Cephalosporins (2nd gen.)"	"J01DC01"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cfox,cfx,cfxt,cx,fox,fx"	"cefoxitin,cefoxitina,cefoxitine,cefoxitinum,cefoxotin,cenomycin,cephoxitin,mefoxin,mefoxitin,rephoxitin"			6	"g"	"25240-3,3448-8"
+"CTS"	9574753	"Cefotaxime/sulbactam"	"Cephalosporins (3rd gen.)"	"NA"			""	""					"54191-2,54192-0,54193-8,55644-9"
+"CTT"	53025	"Cefotetan"	"Cephalosporins (2nd gen.)"	"J01DC05"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cftt,cn,cte,ctn,ctt,tans"	"apacef,cefotan,cefotetan,cefotetan acid,cefotetan free acid,cefotetanum"			4	"g"	"111-5,112-3,113-1,114-9,18887-0,25239-5,3447-0,41672-7,41673-5,41674-3,41729-5,6990-6"
+"CTF"	43708	"Cefotiam"	"Cephalosporins (2nd gen.)"	"J01DC07"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	""	"cefotiam,cefotiam?,cefotiamum,ceradolan,ceradon,haloapor"	1.2	"g"	4	"g"	"32374-1,35772-3,35773-1,55645-6,55737-1,55738-9,55739-7,55740-5"
+"CHE"	125846	"Cefotiam hexetil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefotiam cilexetil,pansporin t"					"55737-1,55738-9,55739-7,55740-5"
+"FOV"	9578573	"Cefovecin"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefovecin"					"76147-8,87792-8"
+"FOX"	441199	"Cefoxitin"	"Cephalosporins (2nd gen.)"	"J01DC01"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cfox,cfx,cfxt,cx,fox,fx"	"cefoxitin,cefoxitina,cefoxitine,cefoxitinum,cefoxotin,cenomycin,cephoxitin,mefoxin,mefoxitin,rephoxitin"			6	"g"	"101492-7,115-6,116-4,117-2,118-0,18888-8,25220-5,25240-3,25366-6,3448-8,41675-0,41676-8,41677-6,41730-3,6991-4"
 "FOX1"		"Cefoxitin screening"	"Cephalosporins (2nd gen.)"	"NA"			"cfsc"	""					""
-"ZOP"	9571080	"Cefozopran"	"Cephalosporins (4th gen.)"	"J01DE03"			""	"cefozopran"			4	"g"	""
+"ZOP"	9571080	"Cefozopran"	"Cephalosporins (4th gen.)"	"J01DE03"			""	"cefozopran"			4	"g"	"100045-4,53820-7"
 "CFZ"	68597	"Cefpimizole"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefpimizol,cefpimizole,cefpimizole sodium,cefpimizolum"					""
 "CPM"	636405	"Cefpiramide"	"Cephalosporins (3rd gen.)"	"J01DD11"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	"cefpiramide,cefpiramide acid,cefpiramido,cefpiramidum"			2	"g"	""
-"CPO"	5479539	"Cefpirome"	"Cephalosporins (4th gen.)"	"J01DE02"	"Other beta-lactam antibacterials"	"Fourth-generation cephalosporins"	"cfpr"	"broact,cefpiroma,cefpirome,cefpiromum,cefrom,cerfpirome,keiten"			4	"g"	""
-"CPD"	6335986	"Cefpodoxime"	"Cephalosporins (3rd gen.)"	"J01DD13"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfpd,cfpo,cpd,pod,px"	"cefpodoxim acid,cefpodoxima,cefpodoxime,cefpodoxime acid,cefpodoximum,epoxim"	0.4	"g"			"25241-1"
+"CPO"	5479539	"Cefpirome"	"Cephalosporins (4th gen.)"	"J01DE02"	"Other beta-lactam antibacterials"	"Fourth-generation cephalosporins"	"cfpr"	"broact,cefpiroma,cefpirome,cefpiromum,cefrom,cerfpirome,keiten"			4	"g"	"18889-6,6647-3,6648-1,6649-9,6650-6,6992-2,8274-3,8275-0,8276-8"
+"CPD"	6335986	"Cefpodoxime"	"Cephalosporins (3rd gen.)"	"J01DD13"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfpd,cfpo,cpd,pod,px"	"cefpodoxim acid,cefpodoxima,cefpodoxime,cefpodoxime acid,cefpodoximum,epoxim"	0.4	"g"			"119-8,120-6,121-4,122-2,18890-4,25241-1,41678-4,41679-2,41680-0,41731-1,6993-0,90849-1"
 "CPX"	6526396	"Cefpodoxime proxetil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefodox,cefoprox,cefpodoxime proxetil,cepodem,orelox,orelox paed,otreon,podomexef,simplicef,vantin"					""
 "CDC"		"Cefpodoxime/clavulanic acid"	"Cephalosporins (3rd gen.)"	"NA"			"cecl"	""					""
-"CPR"	5281006	"Cefprozil"	"Cephalosporins (2nd gen.)"	"J01DC10"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cpr,cpz,fp"	"arzimol,brisoral,cefprozil,cefprozil anhydrous,cefprozil hydrate,cefprozilo,cefprozilum,cefzil,cronocef,procef,serozil"	1	"g"			""
-"CEQ"	5464355	"Cefquinome"	"Cephalosporins (4th gen.)"	"NA"			""	"cefquinoma,cefquinome,cefquinomum,cobactan"					""
+"CPR"	5281006	"Cefprozil"	"Cephalosporins (2nd gen.)"	"J01DC10"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cpr,cpz,fp"	"arzimol,brisoral,cefprozil,cefprozil anhydrous,cefprozil hydrate,cefprozilo,cefprozilum,cefzil,cronocef,procef,serozil"	1	"g"			"123-0,124-8,125-5,126-3,18891-2,6994-8"
+"CEQ"	5464355	"Cefquinome"	"Cephalosporins (4th gen.)"	"NA"			""	"cefquinoma,cefquinome,cefquinomum,cobactan"					"100046-2,76150-2"
 "CRD"	5284529	"Cefroxadine"	"Cephalosporins (1st gen.)"	"J01DB11"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"cefroxadin,cefroxadine,cefroxadino,cefroxadinum,oraspor"	2.1	"g"			""
-"CFS"	656575	"Cefsulodin"	"Cephalosporins (3rd gen.)"	"J01DD03"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfsl,cfsu"	"cefonomil,cefsulodin,cefsulodine,cefsulodino,cefsulodinum"			4	"g"	"131-3,25242-9"
+"CFS"	656575	"Cefsulodin"	"Cephalosporins (3rd gen.)"	"J01DD03"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfsl,cfsu"	"cefonomil,cefsulodin,cefsulodine,cefsulodino,cefsulodinum"			4	"g"	"127-1,128-9,129-7,130-5,131-3,18892-0,25242-9,55647-2"
 "CSU"	68718	"Cefsumide"	"Cephalosporins (unclassified gen.)"	"NA"			""	"cefsulmid,cefsumide,cefsumido,cefsumidum"					""
-"CPT"	56841980	"Ceftaroline"	"Cephalosporins (5th gen.)"	"J01DI02"			"cfro"	"ceftaroline fosamil,teflaro,zinforo"			1.2	"g"	""
-"CPA"		"Ceftaroline/avibactam"	"Cephalosporins (5th gen.)"	"NA"			""	""					""
-"CAZ"	5481173	"Ceftazidime"	"Cephalosporins (3rd gen.)"	"J01DD02"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"caz,cefta,cfta,cftz,taz,tz,xtz"	"ceftazidim,ceftazidima,ceftazidime,ceftazidimum,ceptaz,fortaz,fortum,pentacef,tazicef,tazidime"			4	"g"	"21151-6,3449-6,80960-8"
-"CZA"	90643431	"Ceftazidime/avibactam"	"Cephalosporins (3rd gen.)"	"NA"			"cfav"	"avycaz,zavicefta"					""
+"CPT"	56841980	"Ceftaroline"	"Cephalosporins (5th gen.)"	"J01DI02"			"cfro"	"ceftaroline fosamil,teflaro,zinforo"			1.2	"g"	"73604-1,73605-8,73626-4,73627-2,73649-6,73650-4,74170-2"
+"CPA"		"Ceftaroline/avibactam"	"Cephalosporins (5th gen.)"	"NA"			""	""					"73604-1,73626-4,73649-6"
+"CAZ"	5481173	"Ceftazidime"	"Cephalosporins (3rd gen.)"	"J01DD02"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"caz,cefta,cfta,cftz,taz,tz,xtz"	"ceftazidim,ceftazidima,ceftazidime,ceftazidimum,ceptaz,fortaz,fortum,pentacef,tazicef,tazidime"			4	"g"	"101481-0,101482-8,101483-6,132-1,133-9,134-7,135-4,18893-8,21151-6,3449-6,35774-9,35775-6,35776-4,42352-5,55648-0,55649-8,55650-6,55651-4,58705-5,6995-5,73603-3,73625-6,73648-8,80960-8,87734-0,90850-9"
+"CZA"	90643431	"Ceftazidime/avibactam"	"Cephalosporins (3rd gen.)"	"NA"			"cfav"	"avycaz,zavicefta"					"101483-6,73603-3,73625-6,73648-8,87734-0"
 "CCV"	9575352	"Ceftazidime/clavulanic acid"	"Cephalosporins (3rd gen.)"	"J01DD52"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"czcl,xtzl"	""			6	"g"	""
-"CEM"	6537431	"Cefteram"	"Cephalosporins (3rd gen.)"	"J01DD18"			""	"cefteram,cefterame,cefteramum,ceftetrame"	0.4	"g"			""
+"CEM"	6537431	"Cefteram"	"Cephalosporins (3rd gen.)"	"J01DD18"			""	"cefteram,cefterame,cefteramum,ceftetrame"	0.4	"g"			"100047-0,76144-5"
 "CPL"	5362114	"Cefteram pivoxil"	"Cephalosporins (3rd gen.)"	"NA"			""	"cefteram pivoxil,cefterampivoxil,tomiron"					""
 "CTL"	65755	"Ceftezole"	"Cephalosporins (1st gen.)"	"J01DB12"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	""	"ceftezol,ceftezole,ceftezolo,ceftezolum,demethylcefazolin"			3	"g"	""
-"CTB"	5282242	"Ceftibuten"	"Cephalosporins (3rd gen.)"	"J01DD14"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cb,cfbu,ctb,tib"	"ceftem,ceftibuten,ceftibuten dihydrate,ceftibuten hydrate,ceftibutene,ceftibuteno,ceftibutenum,ceftibutin,cephem,ceprifran,isocef,keimax"	0.4	"g"			""
-"TIO"	6328657	"Ceftiofur"	"Cephalosporins (3rd gen.)"	"NA"			""	"ceftiofur,ceftiofurum,excede,excenel,naxcel"					""
-"CZX"	6533629	"Ceftizoxime"	"Cephalosporins (3rd gen.)"	"J01DD07"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfzx,ctz,cz,czx,tiz,zox"	"cefizox,ceftisomin,ceftix,ceftizoxima,ceftizoxime,ceftizoximum,epocelin,eposerin"			4	"g"	"25243-7,3450-4"
+"CTB"	5282242	"Ceftibuten"	"Cephalosporins (3rd gen.)"	"J01DD14"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cb,cfbu,ctb,tib"	"ceftem,ceftibuten,ceftibuten dihydrate,ceftibuten hydrate,ceftibutene,ceftibuteno,ceftibutenum,ceftibutin,cephem,ceprifran,isocef,keimax"	0.4	"g"			"35777-2,35778-0,35779-8,6996-3"
+"TIO"	6328657	"Ceftiofur"	"Cephalosporins (3rd gen.)"	"NA"			""	"ceftiofur,ceftiofurum,excede,excenel,naxcel"					"23709-9,35780-6,35781-4,55652-2"
+"CZX"	6533629	"Ceftizoxime"	"Cephalosporins (3rd gen.)"	"J01DD07"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"cfzx,ctz,cz,czx,tiz,zox"	"cefizox,ceftisomin,ceftix,ceftizoxima,ceftizoxime,ceftizoximum,epocelin,eposerin"			4	"g"	"136-2,137-0,138-8,139-6,18894-6,20378-6,23622-4,25243-7,3450-4,6997-1"
 "CZP"	9578661	"Ceftizoxime alapivoxil"	"Cephalosporins (3rd gen.)"	"NA"			""	""					""
-"BPR"	135413542	"Ceftobiprole"	"Cephalosporins (5th gen.)"	"NA"			""	"ceftobiprole"					""
+"BPR"	135413542	"Ceftobiprole"	"Cephalosporins (5th gen.)"	"NA"			""	"ceftobiprole"					"43269-0,43270-8,43271-6,43272-4,85052-9"
 "CFM1"	135413544	"Ceftobiprole medocaril"	"Cephalosporins (5th gen.)"	"J01DI01"	"Other beta-lactam antibacterials"	"Other cephalosporins and penems"	""	""			1.5	"g"	""
-"CZT"	86291594	"Ceftolozane/tazobactam"	"Cephalosporins (5th gen.)"	"J01DI54"	"Other beta-lactam antibacterials"	"Other cephalosporins and penems"	"CEI"	"zerbaxa"			3	"g"	""
-"CRO"	5479530	"Ceftriaxone"	"Cephalosporins (3rd gen.)"	"J01DD04"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"axo,cax,cftr,cro,ctr,frx,tx"	"biotrakson,cefatriaxone,cefatriaxone hydrate,ceftriaxon,ceftriaxona,ceftriaxone,ceftriaxone sodium,ceftriaxonum,ceftriazone,cephtriaxone,longacef,rocefin,rocephalin,rocephin,rocephine,rophex"			2	"g"	"25244-5,3451-2,80957-4"
+"CZT"	86291594	"Ceftolozane/tazobactam"	"Cephalosporins (5th gen.)"	"J01DI54"	"Other beta-lactam antibacterials"	"Other cephalosporins and penems"	"CEI"	"zerbaxa"			3	"g"	"101484-4,73602-5,73624-9,73647-0,87735-7"
+"CRO"	5479530	"Ceftriaxone"	"Cephalosporins (3rd gen.)"	"J01DD04"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"axo,cax,cftr,cro,ctr,frx,tx"	"biotrakson,cefatriaxone,cefatriaxone hydrate,ceftriaxon,ceftriaxona,ceftriaxone,ceftriaxone sodium,ceftriaxonum,ceftriazone,cephtriaxone,longacef,rocefin,rocephalin,rocephin,rocephine,rophex"			2	"g"	"101485-1,140-4,141-2,142-0,143-8,18895-3,25244-5,25367-4,31140-7,31141-5,3451-2,41681-8,41682-6,41683-4,41732-9,50633-7,55190-3,6998-9,80957-4"
 "CEB"		"Ceftriaxone/beta-lactamase inhibitor"	"Cephalosporins (3rd gen.)"	"J01DD63"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	""	""			2	"g"	""
-"CXM"	5479529	"Cefuroxime"	"Cephalosporins (2nd gen.)"	"J01DC02,S01AA27"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cfrx,cfur,cfx,crm,cxm,fur,rox,xm"	"biofuroksym,cefuril,cefuroxim,cefuroxima,cefuroxime,cefuroxime acid,cefuroximine,cefuroximo,cefuroximum,cephuroxime,kefurox,sharox,zinacef,zinacef danmark"	0.5	"g"	3	"g"	"25245-2,3452-0,80608-3,80617-4"
+"CXM"	5479529	"Cefuroxime"	"Cephalosporins (2nd gen.)"	"J01DC02,S01AA27"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"cfrx,cfur,cfx,crm,cxm,fur,rox,xm"	"biofuroksym,cefuril,cefuroxim,cefuroxima,cefuroxime,cefuroxime acid,cefuroximine,cefuroximo,cefuroximum,cephuroxime,kefurox,sharox,zinacef,zinacef danmark"	0.5	"g"	3	"g"	"101503-1,144-6,145-3,146-1,147-9,18896-1,20460-2,25245-2,3452-0,35782-2,35783-0,51724-3,51774-8,55653-0,55654-8,6999-7,74699-0,80608-3,80617-4"
 "CXA"	6321416	"Cefuroxime axetil"	"Cephalosporins (2nd gen.)"	"NA"			"cfax"	"altacef,bioracef,cefaks,cefazine,ceftin,cefurax,cefuroximaxetil,cefuroxime,cefuroxime axetil,celocid,cepazine,cethixim,cetoxil,coliofossim,elobact,forcef,furoxime,kalcef,maxitil,medoxm,nivador,novador,novocef,oraxim,zinnat"					""
 "CFM2"		"Cefuroxime/metronidazole"	"Other antibacterials"	"J01RA03"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "ZON"	6336505	"Cefuzonam"	"Other antibacterials"	"NA"			""	"cefuzonam,cefuzonam sodium,cefuzoname,cefuzonamum"					""
-"CED"	38103	"Cephradine"	"Cephalosporins (1st gen.)"	"J01DB09"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfra,cfrd"	"anspor,cefradin,cefradina,cefradine,cefradine hydrate,cefradinum,cekodin,cephradin,cephradine,cephradine anhydrous,cephradine hydrate,eskacef,infexin,megace f,megacef,sefril,velocef,velosef"	2	"g"	2	"g"	""
+"CED"	38103	"Cephradine"	"Cephalosporins (1st gen.)"	"J01DB09"	"Other beta-lactam antibacterials"	"First-generation cephalosporins"	"cfra,cfrd"	"anspor,cefradin,cefradina,cefradine,cefradine hydrate,cefradinum,cekodin,cephradin,cephradine,cephradine anhydrous,cephradine hydrate,eskacef,infexin,megace f,megacef,sefril,velocef,velosef"	2	"g"	2	"g"	"168-5,169-3,170-1,171-9,18902-7,55646-4"
 "CTO"	71402	"Cetocycline"	"Tetracyclines"	"NA"			""	"cetocycline,cetocyline,cetotetrine,chelocardin"					""
-"CHL"	5959	"Chloramphenicol"	"Amphenicols"	"D06AX02,D10AF03,G01AA05,J01BA01,S01AA01,S02AA01,S03AA08"	"Amphenicols"	"Amphenicols"	"c,chl,chlo,cl"	"alficetyn,ambofen,amphenicol,amphicol,amseclor,anacetin,aquamycetin,austracil,austracol,biocetin,biophenicol,catilan,ch loramex,chemiceticol,chemicetin,chemicetina,chlomin,chlomycol,chloramex,chloramfenikol,chloramficin,chloramfilin,chloramphenicol,chloramphenicole,chloramphenicolum,chloramsaar,chlorasol,chlorbiotic,chloricol,chlormycetin r,chlornitromycin,chloroamphenicol,chlorocaps,chlorocid,chlorocid s,chlorocide,chlorocidin c,chlorocidin c tetran,chlorocin,chlorocol,chlorofair,chloroject l,chloromax,chloromycetin,chloromycetny,chloromyxin,chloronitrin,chloroptic,chloroptic s.o.p,chloroptic s.o.p.,chlorovules,chlorsig,cidocetine,ciplamycetin,cloramfen,cloramfenicol,cloramfenicolo,cloramficin,cloramical,cloramicol,cloramidina,cloranfenicol,cloroamfenicolo,clorocyn,cloromisan,cloromissan,clorosintex,comycetin,cylphenicol,desphen,detreomycin,detreomycine,dextromycetin,doctamicina,duphenicol,econochlor,embacetin,emetren,enicol,enteromycetin,erbaplast,ertilen,f armicetina,farmicetina,fenicol,globenicol,glorous,gloveticol,halcetin,halomycetin,hortfenicol,interomycetine,intramycetin,intramyctin,isicetin,ismicetina,isophenicol,isopto fenicol,juvamycetin,kamaver,kemicetina,kemicetine,kloramfenikol,klorita,klorocid s,laevomycetinum,leukamycin,leukomyan,leukomycin,levocin,levomicetina,levomitsetin,levomycetin,levoplast,levosin,levovetin,loromicetina,loromisan,loromisin,mastiphen,mediamycetine,medichol,micloretin,micochlorine,micoclorina,microcetina,mychel,mycinol,myclocin,mycochlorin,myscel,normimycin v,novochlorocap,novomycetin,novophenicol,ocuphenicol,oftalent,oleomycetin,opclor,opelor,ophthochlor,ophthocort,ophtochlor,optomycin,otachron,otophen,pantovernil,paraxin,pentamycetin,quemicetina,rivomycin,romphenil,ronfenil,ronphenil,septicol,sificetina,sintomicetin,sintomicetina,sintomicetine r,sno phenicol,soluthor,stanomycetin,synthomycetin,synthomycetine,synthomycine,syntomycin,tevcocin,tevcosin,tifomycin,tifomycine,tiromycetin,treomicetina,tyfomycine,unimycetin,veticol,vice ton,viceton"	3	"g"	3	"g"	"15101-9,16603-3,16604-1,25247-8,29214-4,29346-4,29347-2,3455-3"
-"CTE"	54675777	"Chlortetracycline"	"Tetracyclines"	"A01AB21,D06AA02,J01AA03,S01AA02"	"Tetracyclines"	"Tetracyclines"	""	"acronize,aueromycin,aureocina,aureomycin,aureomykoin,biomitsin,biomycin,biomycin a,chlormax,chlorotetracycline,chlortetracycline,chlortetracyclinum,chrysomykine,clortetraciclina,duomycin,flamycin,uromycin"	1	"g"			"87600-3"
+"CHL"	5959	"Chloramphenicol"	"Amphenicols"	"D06AX02,D10AF03,G01AA05,J01BA01,S01AA01,S02AA01,S03AA08"	"Amphenicols"	"Amphenicols"	"c,chl,chlo,cl"	"alficetyn,ambofen,amphenicol,amphicol,amseclor,anacetin,aquamycetin,austracil,austracol,biocetin,biophenicol,catilan,ch loramex,chemiceticol,chemicetin,chemicetina,chlomin,chlomycol,chloramex,chloramfenikol,chloramficin,chloramfilin,chloramphenicol,chloramphenicole,chloramphenicolum,chloramsaar,chlorasol,chlorbiotic,chloricol,chlormycetin r,chlornitromycin,chloroamphenicol,chlorocaps,chlorocid,chlorocid s,chlorocide,chlorocidin c,chlorocidin c tetran,chlorocin,chlorocol,chlorofair,chloroject l,chloromax,chloromycetin,chloromycetny,chloromyxin,chloronitrin,chloroptic,chloroptic s.o.p,chloroptic s.o.p.,chlorovules,chlorsig,cidocetine,ciplamycetin,cloramfen,cloramfenicol,cloramfenicolo,cloramficin,cloramical,cloramicol,cloramidina,cloranfenicol,cloroamfenicolo,clorocyn,cloromisan,cloromissan,clorosintex,comycetin,cylphenicol,desphen,detreomycin,detreomycine,dextromycetin,doctamicina,duphenicol,econochlor,embacetin,emetren,enicol,enteromycetin,erbaplast,ertilen,f armicetina,farmicetina,fenicol,globenicol,glorous,gloveticol,halcetin,halomycetin,hortfenicol,interomycetine,intramycetin,intramyctin,isicetin,ismicetina,isophenicol,isopto fenicol,juvamycetin,kamaver,kemicetina,kemicetine,kloramfenikol,klorita,klorocid s,laevomycetinum,leukamycin,leukomyan,leukomycin,levocin,levomicetina,levomitsetin,levomycetin,levoplast,levosin,levovetin,loromicetina,loromisan,loromisin,mastiphen,mediamycetine,medichol,micloretin,micochlorine,micoclorina,microcetina,mychel,mycinol,myclocin,mycochlorin,myscel,normimycin v,novochlorocap,novomycetin,novophenicol,ocuphenicol,oftalent,oleomycetin,opclor,opelor,ophthochlor,ophthocort,ophtochlor,optomycin,otachron,otophen,pantovernil,paraxin,pentamycetin,quemicetina,rivomycin,romphenil,ronfenil,ronphenil,septicol,sificetina,sintomicetin,sintomicetina,sintomicetine r,sno phenicol,soluthor,stanomycetin,synthomycetin,synthomycetine,synthomycine,syntomycin,tevcocin,tevcosin,tifomycin,tifomycine,tiromycetin,treomicetina,tyfomycine,unimycetin,veticol,vice ton,viceton"	3	"g"	3	"g"	"15101-9,16603-3,16604-1,172-7,173-5,174-3,175-0,18903-5,25247-8,29214-4,29346-4,29347-2,3455-3,7001-1"
+"CTE"	54675777	"Chlortetracycline"	"Tetracyclines"	"A01AB21,D06AA02,J01AA03,S01AA02"	"Tetracyclines"	"Tetracyclines"	""	"acronize,aueromycin,aureocina,aureomycin,aureomykoin,biomitsin,biomycin,biomycin a,chlormax,chlorotetracycline,chlortetracycline,chlortetracyclinum,chrysomykine,clortetraciclina,duomycin,flamycin,uromycin"	1	"g"			"176-8,177-6,178-4,179-2,18904-3,55655-5,87600-3"
 "CIC"	19003	"Ciclacillin"	"Beta-lactams/penicillins"	"NA"			""	"bastcillin,calthor,ciclacilina,ciclacillin,ciclacilline,ciclacillinum,ciclacillum,citosarin,cyclacillin,cyclapen,noblicil,orfilina,peamezin,syngacillin,ultracillin,vastcillin,vipicil,wyvital"					""
 "CIX"	47472	"Ciclopirox"	"Antifungals/antimycotics"	"D01AE14,G01AX12"	"Antifungals for topical use"	"Other antifungals for topical use"	"cipx"	"butaconazole,butoconazol,butoconazole,butoconazolum,ciclodan,ciclopirox,ciclopirox gel,ciclopirox olamin,ciclopiroxum,compositenstarke,dahlin,femstat,gynofort,loprox,loprox cream,loprox gel,penlac,polyfructosanum,stieprox"					""
-"CIN"	2762	"Cinoxacin"	"Quinolones"	"J01MB06"	"Quinolone antibacterials"	"Other quinolones"	"cino,cnox"	"azolinic acid,cinobac,cinobactin,cinoxacin,cinoxacine,cinoxacino,cinoxacinum,clinoxacin,noxigram,uronorm"	1	"g"			""
-"CIP"	2764	"Ciprofloxacin"	"Quinolones"	"J01MA02,S01AE03,S02AA15,S03AA07"	"Quinolone antibacterials"	"Fluoroquinolones"	"ci,cip,cipr,cp"	"alcon cilox,auripro,bacquinor,baflox,baycip,bernoflox,cetraxal,ciflox,cifloxin,ciloxan,ciplus,ciprecu,ciprine,ciprinol,cipro i.v.,cipro iv,cipro xl,cipro xr,ciprobay,ciprobay uro,ciprocinol,ciprodar,ciproflox,ciprofloxacin,ciprofloxacina,ciprofloxacine,ciprofloxacino,ciprofloxacinum,ciprogis,ciprolin,ciprolon,cipromycin,ciproquinol,ciprowin,ciproxan,ciproxin,ciproxina,ciproxine,ciriax,citopcin,corsacin,cyprobay,fimoflox,flociprin,ipiflox,italnik,linhaliq,otiprio,probiox,proflaxin,quinolid,quintor,rancif,roxytal,septicide,sophixin ofteno,spitacin,superocin,velmonit,velomonit,zumaflox"	1	"g"	0.8	"g"	"14031-9,14032-7,14058-2,14059-0,25248-6,34636-1,3484-3"
+"CIN"	2762	"Cinoxacin"	"Quinolones"	"J01MB06"	"Quinolone antibacterials"	"Other quinolones"	"cino,cnox"	"azolinic acid,cinobac,cinobactin,cinoxacin,cinoxacine,cinoxacino,cinoxacinum,clinoxacin,noxigram,uronorm"	1	"g"			"180-0,181-8,182-6,183-4,18905-0,55656-3"
+"CIP"	2764	"Ciprofloxacin"	"Quinolones"	"J01MA02,S01AE03,S02AA15,S03AA07"	"Quinolone antibacterials"	"Fluoroquinolones"	"ci,cip,cipr,cp"	"alcon cilox,auripro,bacquinor,baflox,baycip,bernoflox,cetraxal,ciflox,cifloxin,ciloxan,ciplus,ciprecu,ciprine,ciprinol,cipro i.v.,cipro iv,cipro xl,cipro xr,ciprobay,ciprobay uro,ciprocinol,ciprodar,ciproflox,ciprofloxacin,ciprofloxacina,ciprofloxacine,ciprofloxacino,ciprofloxacinum,ciprogis,ciprolin,ciprolon,cipromycin,ciproquinol,ciprowin,ciproxan,ciproxin,ciproxina,ciproxine,ciriax,citopcin,corsacin,cyprobay,fimoflox,flociprin,ipiflox,italnik,linhaliq,otiprio,probiox,proflaxin,quinolid,quintor,rancif,roxytal,septicide,sophixin ofteno,spitacin,superocin,velmonit,velomonit,zumaflox"	1	"g"	0.8	"g"	"101500-7,14031-9,14032-7,14058-2,14059-0,184-2,185-9,186-7,187-5,18906-8,20377-8,23621-6,25180-1,25181-9,25188-4,25189-2,25248-6,34636-1,3484-3,42644-5,55194-5,7002-9"
 "CIM"		"Ciprofloxacin/metronidazole"	"Other antibacterials"	"J01RA10"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "CIO"		"Ciprofloxacin/ornidazole"	"Other antibacterials"	"J01RA12"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "CIT"		"Ciprofloxacin/tinidazole"	"Other antibacterials"	"J01RA11"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
-"CLR"	84029	"Clarithromycin"	"Macrolides/lincosamides"	"J01FA09"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"ch,cla,clar,clm,clr"	"abbotic,astromen,biaxin,biaxin filmtab,biaxin hp,biaxin xl,biaxin xl filmtab,bicrolid,clacee,clacid,clacine,clambiotic,clarem,claribid,claricide,claridar,claripen,clarith,clarithromycin,clarithromycine,clarithromycinum,claritromicina,clathromycin,crixan,cyllid,cyllind,fromilid,heliclar,klabax,klacid,klaciped,klaricid,klaricid h.p,klaricid h.p.,klaricid pediatric,klaricid xl,klarid,klarin,kofron,mabicrol,macladin,maclar,prevpac,veclam,vikrol,zeclar"	0.5	"g"	1	"g"	"16619-9,25253-6,34638-7,80559-8"
+"CLR"	84029	"Clarithromycin"	"Macrolides/lincosamides"	"J01FA09"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"ch,cla,clar,clm,clr"	"abbotic,astromen,biaxin,biaxin filmtab,biaxin hp,biaxin xl,biaxin xl filmtab,bicrolid,clacee,clacid,clacine,clambiotic,clarem,claribid,claricide,claridar,claripen,clarith,clarithromycin,clarithromycine,clarithromycinum,claritromicina,clathromycin,crixan,cyllid,cyllind,fromilid,heliclar,klabax,klacid,klaciped,klaricid,klaricid h.p,klaricid h.p.,klaricid pediatric,klaricid xl,klarid,klarin,kofron,mabicrol,macladin,maclar,prevpac,veclam,vikrol,zeclar"	0.5	"g"	1	"g"	"100048-8,16619-9,16620-7,188-3,189-1,18907-6,190-9,191-7,20375-2,23619-0,25190-0,25191-8,25192-6,25253-6,34638-7,43987-7,43990-1,43991-9,7003-7,80559-8,89485-7"
 "CLA1"	5280980	"Clavulanic acid"	"Other antibacterials"	"NA"			""	"acide clavulanique,acido clavulanico,acidum clavulanicum,clavulanate,clavulanate acid,clavulanate lithium,clavulanateacid,clavulanic acid,clavulansaeure,clavulansaure,clavulinic acid,clavulox,serdaxin,sodium clavulanate"					""
-"CLX"	60063	"Clinafloxacin"	"Quinolones"	"NA"			""	"clinafloxacin"					""
-"CLI"	446598	"Clindamycin"	"Macrolides/lincosamides"	"D10AF01,G01AA10,J01FF01"	"Macrolides, lincosamides and streptogramins"	"Lincosamides"	"cc,cd,cli,clin,cm,da"	"antirobe,chlolincocin,clindaderm,clindamicina,clindamycin,clindamycine,clindamycinum,clinimycin,dalacin c,dalacine,klimicin,sobelin"	1.2	"g"	1.8	"g"	"16621-5,16622-3,25249-4,3486-8"
-"CLF"	2794	"Clofazimine"	"Antimycobacterials"	"J04BA01"	"Drugs for treatment of lepra"	"Drugs for treatment of lepra"	"clof"	"chlofazimine,clofazimin,clofazimina,clofazimine,clofaziminum,colfazimine,lampren,lamprene,riminophenazine"	0.1	"g"			""
+"CLX"	60063	"Clinafloxacin"	"Quinolones"	"NA"			""	"clinafloxacin"					"32376-6,33284-1,35785-5,35786-3,7004-5"
+"CLI"	446598	"Clindamycin"	"Macrolides/lincosamides"	"D10AF01,G01AA10,J01FF01"	"Macrolides, lincosamides and streptogramins"	"Lincosamides"	"cc,cd,cli,clin,cm,da"	"antirobe,chlolincocin,clindaderm,clindamicina,clindamycin,clindamycine,clindamycinum,clinimycin,dalacin c,dalacine,klimicin,sobelin"	1.2	"g"	1.8	"g"	"16621-5,16622-3,18908-4,192-5,193-3,194-1,195-8,25249-4,3486-8,42720-3,55657-1,55658-9,55659-7,55660-5,61188-9,7005-2"
+"CLF"	2794	"Clofazimine"	"Antimycobacterials"	"J04BA01"	"Drugs for treatment of lepra"	"Drugs for treatment of lepra"	"clof"	"chlofazimine,clofazimin,clofazimina,clofazimine,clofaziminum,colfazimine,lampren,lamprene,riminophenazine"	0.1	"g"			"16623-1,20376-0,23620-8,23627-3,43986-9,43988-5,43989-3,55661-3,55662-1,96108-6"
 "CLF1"	2799	"Clofoctol"	"Other antibacterials"	"J01XX03"	"Other antibacterials"	"Other antibacterials"	""	"clofoctol,clofoctolo,clofoctolum,gramplus,octofene"					""
 "CLM"	71807	"Clometocillin"	"Beta-lactams/penicillins"	"J01CE07"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	""	"chlomethocillin,clometacillin,clometocilina,clometocillin,clometocilline,clometocillinum,rixapen"	1	"g"			""
 "CLM1"	54680675	"Clomocycline"	"Tetracyclines"	"J01AA11"	"Tetracyclines"	"Tetracyclines"	""	"chlormethylencycline,clomociclina,clomocyclin,clomocycline,clomocyclinum,megaclor"	1	"g"			""
-"CTR"	2812	"Clotrimazole"	"Antifungals/antimycotics"	"A01AB18,D01AC01,G01AF02"			"clot"	"canesten,canesten cream,canesten solution,canestene,canestine,canifug,chlotrimazole,cimitidine,clomatin,clotrimaderm,clotrimaderm cream,clotrimazol,clotrimazole,clotrimazolum,cutistad,desamix f,diphenylmethane,empecid,esparol,fem care,femcare,gyne lotrimin,jidesheng,kanesten,klotrimazole,lotrimax,lotrimin,lotrimin af,lotrimin af cream,lotrimin af lotion,lotrimin af solution,lotrimin cream,lotrimin lotion,lotrimin solution,monobaycuten,mycelax,mycelex,mycelex cream,mycelex g,mycelex otc,mycelex solution,mycelex troches,mycelex twin pack,myclo cream,myclo solution,myclo spray solution,mycofug,mycosporin,mykosporin,nalbix,otomax,pedisafe,rimazole,stiemazol,tibatin,trimysten,trivagizole,veltrim"					""
-"CLO"	6098	"Cloxacillin"	"Beta-lactams/penicillins"	"J01CF02"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"clox"	"chloroxacillin,clossacillina,cloxacilina,cloxacillin,cloxacillin sodium,cloxacilline,cloxacillinna,cloxacillinum,cloxapen,methocillin s,orbenin,syntarpen,tegopen"	2	"g"	2	"g"	"16628-0,25250-2"
-"COL"	5311054	"Colistin"	"Polymyxins"	"A07AA10,J01XB01"	"Other antibacterials"	"Polymyxins"	"cl,coli,cs,cst,ct"	"belcomycine,colimycin,colimycin sulphate,colisticin,colistimethate,colistimethate sodium,colistin sulfate,colistin sulphate,colobreathe,colomycin,coly-mycin,polymyxin e,polymyxin e. sulfate,promixin,totazina"	9	"MU"	9	"MU"	"16645-4,29493-4"
+"CTR"	2812	"Clotrimazole"	"Antifungals/antimycotics"	"A01AB18,D01AC01,G01AF02"			"clot"	"canesten,canesten cream,canesten solution,canestene,canestine,canifug,chlotrimazole,cimitidine,clomatin,clotrimaderm,clotrimaderm cream,clotrimazol,clotrimazole,clotrimazolum,cutistad,desamix f,diphenylmethane,empecid,esparol,fem care,femcare,gyne lotrimin,jidesheng,kanesten,klotrimazole,lotrimax,lotrimin,lotrimin af,lotrimin af cream,lotrimin af lotion,lotrimin af solution,lotrimin cream,lotrimin lotion,lotrimin solution,monobaycuten,mycelax,mycelex,mycelex cream,mycelex g,mycelex otc,mycelex solution,mycelex troches,mycelex twin pack,myclo cream,myclo solution,myclo spray solution,mycofug,mycosporin,mykosporin,nalbix,otomax,pedisafe,rimazole,stiemazol,tibatin,trimysten,trivagizole,veltrim"					"10653-4,10654-2,18909-2,54177-1,55663-9"
+"CLO"	6098	"Cloxacillin"	"Beta-lactams/penicillins"	"J01CF02"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"clox"	"chloroxacillin,clossacillina,cloxacilina,cloxacillin,cloxacillin sodium,cloxacilline,cloxacillinna,cloxacillinum,cloxapen,methocillin s,orbenin,syntarpen,tegopen"	2	"g"	2	"g"	"16628-0,18910-0,196-6,197-4,198-2,199-0,25250-2,55664-7"
+"COL"	5311054	"Colistin"	"Polymyxins"	"A07AA10,J01XB01"	"Other antibacterials"	"Polymyxins"	"cl,coli,cs,cst,ct"	"belcomycine,colimycin,colimycin sulphate,colisticin,colistimethate,colistimethate sodium,colistin sulfate,colistin sulphate,colobreathe,colomycin,coly-mycin,polymyxin e,polymyxin e. sulfate,promixin,totazina"	9	"MU"	9	"MU"	"16645-4,18912-6,204-8,205-5,206-3,207-1,29493-4,33333-6"
 "COP"		"Colistin/polysorbate"	"Other antibacterials"	"NA"			""	""					""
-"CYC"	6234	"Cycloserine"	"Oxazolidinones"	"J04AB01"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"cycl"	"cicloserina,closerin,closina,cyclorin,cycloserin,cycloserine,cycloserinum,farmiserina,micoserina,miroserina,miroseryn,novoserin,oxamicina,oxamycin,seromycin,tebemicina,tisomycin,wasserina"	0.75	"g"			"16702-3,25251-0,3519-6"
-"DAL"	23724878	"Dalbavancin"	"Glycopeptides"	"J01XA04"	"Other antibacterials"	"Glycopeptide antibacterials"	"dalb"	"dalbavancin,dalvance"			1.5	"g"	""
-"DAN"	71335	"Danofloxacin"	"Quinolones"	"NA"			""	"advocin,danofloxacin,danofloxacine,danofloxacino,danofloxacinum"					""
-"DPS"	2955	"Dapsone"	"Other antibacterials"	"D10AX05,J04BA02"	"Drugs for treatment of lepra"	"Drugs for treatment of lepra"	""	"aczone,araldite ht,atrisone,avlosulfon,avlosulfone,avlosulphone,avsulfor,bis sulfone,bissulfone,bissulphone,croysulfone,croysulphone,dapson,dapsona,dapsone,dapsonum,di sulfone,diaphenyl sulfone,diaphenylsulfon,diaphenylsulfone,diaphenylsulphon,diaphenylsulphone,dimitone,diphenasone,diphone,disulfone,disulone,disulphone,dubronax,dubronaz,dumitone,eporal,metabolite c,novophone,protogen,servidapson,slphadione,sulfadione,sulfona,sulfone ucb,sulfonyldianiline,sulphadione,sulphonyldianiline,sumicure s,tarimyl,udolac"	50	"mg"			"9747-7"
-"DAP"	16134395	"Daptomycin"	"Other antibacterials"	"J01XX09"	"Other antibacterials"	"Other antibacterials"	"dap,dapt"	"cidecin,cubicin,dapcin,daptomicina,daptomycine,daptomycinum"			0.28	"g"	""
-"DFX"	487101	"Delafloxacin"	"Quinolones"	"J01MA23"			""	"baxdela,delafloxacin,delafloxacinum,quofenix"	0.9	"g"	0.6	"g"	""
-"DLM"	6480466	"Delamanid"	"Antimycobacterials"	"J04AK06"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"dela"	"delamanid,deltyba"	0.2	"g"			""
-"DEM"	54680690	"Demeclocycline"	"Tetracyclines"	"D06AA01,J01AA01"	"Tetracyclines"	"Tetracyclines"	""	"bioterciclin,clortetrin,declomycin,deganol,demeclociclina,demeclocycline,demeclocyclinum,demeclor,demetraclin,diuciclin,elkamicina,ledermycin,mexocine,novotriclina,perciclina,sumaclina"	0.6	"g"			"10982-7,29494-2"
-"DKB"	470999	"Dibekacin"	"Aminoglycosides"	"J01GB09"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	""	"debecacin,dibekacin,dibekacin sulfate,dibekacina,dibekacine,dibekacinum,dideoxykanamycin b,kappati,orbicin,panamicin"			0.14	"g"	""
-"DIC"	18381	"Dicloxacillin"	"Beta-lactams/penicillins"	"J01CF01"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"dicl"	"dichloroxacillin,diclossacillina,dicloxaciclin,dicloxacilin,dicloxacilina,dicloxacillin,dicloxacillin sodium,dicloxacillina,dicloxacilline,dicloxacillinum,dicloxacycline,dycill,dynapen,maclicine,nm|| dicloxacillin,pathocil"	2	"g"	2	"g"	"10984-3,16769-2,25252-8"
-"DIF"	56206	"Difloxacin"	"Quinolones"	"NA"			""	"dicural,difloxacin,pulsaflox"					""
-"DIR"	6473883	"Dirithromycin"	"Macrolides/lincosamides"	"J01FA13"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"dirithromycin,dirithromycine,dirithromycinum,diritromicina,divitross,dynabac,noriclan,valodin"	0.5	"g"			""
-"DOR"	73303	"Doripenem"	"Carbapenems"	"J01DH04"	"Other beta-lactam antibacterials"	"Carbapenems"	"dori"	"doribax,doripenem,doripenem hydrate,finibax"			1.5	"g"	""
-"DOX"	54671203	"Doxycycline"	"Tetracyclines"	"A01AB22,J01AA02"	"Tetracyclines"	"Tetracyclines"	"dox,doxy"	"atridox,azudoxat,deoxymykoin,dossiciclina,doxcycline anhydrous,doxiciclina,doxirobe,doxitard,doxivetin,doxycen,doxychel,doxycin,doxycyclin,doxycycline,doxycycline calcium,doxycycline hyclate,doxycyclinum,doxylin,doxysol,doxytec,doxytetracycline,hydramycin,investin,jenacyclin,liviatin,monodox,oracea,periostat,ronaxan,spanor,supracyclin,vibramycin,vibramycin novum,vibramycine,vibravenos,zenavod"	0.1	"g"	0.1	"g"	"10986-8,21250-6,26902-7"
-"ECO"	3198	"Econazole"	"Antifungals/antimycotics"	"D01AC03,G01AF05"	"Antifungals for topical use"	"Imidazole and triazole derivatives"	"econ"	"econazol,econazole,econazolum,ecostatin,ecostatin cream,palavale,pevaryl,spectazole,spectazole cream"					""
-"ENX"	3229	"Enoxacin"	"Quinolones"	"J01MA04"	"Quinolone antibacterials"	"Fluoroquinolones"	"enox"	"almitil,bactidan,bactidron,comprecin,enofloxacine,enoksetin,enoram,enoxacin,enoxacina,enoxacine,enoxacino,enoxacinum,enoxen,enoxin,enoxor,flumark,penetrex"	0.8	"g"			"16816-1,3590-7"
-"ENR"	71188	"Enrofloxacin"	"Quinolones"	"NA"			""	"baytril,enrofloxacin,enrofloxacine,enrofloxacino,enrofloxacinum,enroxil"					""
+"CYC"	6234	"Cycloserine"	"Oxazolidinones"	"J04AB01"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"cycl"	"cicloserina,closerin,closina,cyclorin,cycloserin,cycloserine,cycloserinum,farmiserina,micoserina,miroserina,miroseryn,novoserin,oxamicina,oxamycin,seromycin,tebemicina,tisomycin,wasserina"	0.75	"g"			"16702-3,18914-2,212-1,213-9,214-7,215-4,23608-3,25207-2,25208-0,25209-8,25251-0,3519-6,55667-0"
+"DAL"	23724878	"Dalbavancin"	"Glycopeptides"	"J01XA04"	"Other antibacterials"	"Glycopeptide antibacterials"	"dalb"	"dalbavancin,dalvance"			1.5	"g"	"41688-3,41689-1,41690-9,41734-5"
+"DAN"	71335	"Danofloxacin"	"Quinolones"	"NA"			""	"advocin,danofloxacin,danofloxacine,danofloxacino,danofloxacinum"					"73601-7,73623-1,73646-2"
+"DPS"	2955	"Dapsone"	"Other antibacterials"	"D10AX05,J04BA02"	"Drugs for treatment of lepra"	"Drugs for treatment of lepra"	""	"aczone,araldite ht,atrisone,avlosulfon,avlosulfone,avlosulphone,avsulfor,bis sulfone,bissulfone,bissulphone,croysulfone,croysulphone,dapson,dapsona,dapsone,dapsonum,di sulfone,diaphenyl sulfone,diaphenylsulfon,diaphenylsulfone,diaphenylsulphon,diaphenylsulphone,dimitone,diphenasone,diphone,disulfone,disulone,disulphone,dubronax,dubronaz,dumitone,eporal,metabolite c,novophone,protogen,servidapson,slphadione,sulfadione,sulfona,sulfone ucb,sulfonyldianiline,sulphadione,sulphonyldianiline,sumicure s,tarimyl,udolac"	50	"mg"			"51698-9,9747-7"
+"DAP"	16134395	"Daptomycin"	"Other antibacterials"	"J01XX09"	"Other antibacterials"	"Other antibacterials"	"dap,dapt"	"cidecin,cubicin,dapcin,daptomicina,daptomycine,daptomycinum"			0.28	"g"	"35787-1,35788-9,35789-7,41691-7"
+"DFX"	487101	"Delafloxacin"	"Quinolones"	"J01MA23"			""	"baxdela,delafloxacin,delafloxacinum,quofenix"	0.9	"g"	0.6	"g"	"88885-9,90447-4,93790-4"
+"DLM"	6480466	"Delamanid"	"Antimycobacterials"	"J04AK06"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"dela"	"delamanid,deltyba"	0.2	"g"			"93851-4,96109-4"
+"DEM"	54680690	"Demeclocycline"	"Tetracyclines"	"D06AA01,J01AA01"	"Tetracyclines"	"Tetracyclines"	""	"bioterciclin,clortetrin,declomycin,deganol,demeclociclina,demeclocycline,demeclocyclinum,demeclor,demetraclin,diuciclin,elkamicina,ledermycin,mexocine,novotriclina,perciclina,sumaclina"	0.6	"g"			"10982-7,18915-9,216-2,217-0,218-8,219-6,29494-2,7006-0"
+"DKB"	470999	"Dibekacin"	"Aminoglycosides"	"J01GB09"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	""	"debecacin,dibekacin,dibekacin sulfate,dibekacina,dibekacine,dibekacinum,dideoxykanamycin b,kappati,orbicin,panamicin"			0.14	"g"	"55669-6,55670-4,55671-2,55672-0"
+"DIC"	18381	"Dicloxacillin"	"Beta-lactams/penicillins"	"J01CF01"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"dicl"	"dichloroxacillin,diclossacillina,dicloxaciclin,dicloxacilin,dicloxacilina,dicloxacillin,dicloxacillin sodium,dicloxacillina,dicloxacilline,dicloxacillinum,dicloxacycline,dycill,dynapen,maclicine,nm|| dicloxacillin,pathocil"	2	"g"	2	"g"	"10984-3,16769-2,18916-7,220-4,221-2,222-0,223-8,25252-8,32380-8,55668-8"
+"DIF"	56206	"Difloxacin"	"Quinolones"	"NA"			""	"dicural,difloxacin,pulsaflox"					"35790-5,35791-3,35792-1"
+"DIR"	6473883	"Dirithromycin"	"Macrolides/lincosamides"	"J01FA13"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"dirithromycin,dirithromycine,dirithromycinum,diritromicina,divitross,dynabac,noriclan,valodin"	0.5	"g"			"35793-9,35794-7,35795-4,7007-8"
+"DOR"	73303	"Doripenem"	"Carbapenems"	"J01DH04"	"Other beta-lactam antibacterials"	"Carbapenems"	"dori"	"doribax,doripenem,doripenem hydrate,finibax"			1.5	"g"	"56031-8,58711-3,60535-2,72893-1"
+"DOX"	54671203	"Doxycycline"	"Tetracyclines"	"A01AB22,J01AA02"	"Tetracyclines"	"Tetracyclines"	"dox,doxy"	"atridox,azudoxat,deoxymykoin,dossiciclina,doxcycline anhydrous,doxiciclina,doxirobe,doxitard,doxivetin,doxycen,doxychel,doxycin,doxycyclin,doxycycline,doxycycline calcium,doxycycline hyclate,doxycyclinum,doxylin,doxysol,doxytec,doxytetracycline,hydramycin,investin,jenacyclin,liviatin,monodox,oracea,periostat,ronaxan,spanor,supracyclin,vibramycin,vibramycin novum,vibramycine,vibravenos,zenavod"	0.1	"g"	0.1	"g"	"10986-8,18917-5,20379-4,21250-6,224-6,225-3,226-1,227-9,23623-2,25223-9,26902-7,7008-6"
+"ECO"	3198	"Econazole"	"Antifungals/antimycotics"	"D01AC03,G01AF05"	"Antifungals for topical use"	"Imidazole and triazole derivatives"	"econ"	"econazol,econazole,econazolum,ecostatin,ecostatin cream,palavale,pevaryl,spectazole,spectazole cream"					"25595-0,25637-0,54178-9,55673-8"
+"ENX"	3229	"Enoxacin"	"Quinolones"	"J01MA04"	"Quinolone antibacterials"	"Fluoroquinolones"	"enox"	"almitil,bactidan,bactidron,comprecin,enofloxacine,enoksetin,enoram,enoxacin,enoxacina,enoxacine,enoxacino,enoxacinum,enoxen,enoxin,enoxor,flumark,penetrex"	0.8	"g"			"16816-1,18918-3,228-7,229-5,230-3,231-1,3590-7,41692-5"
+"ENR"	71188	"Enrofloxacin"	"Quinolones"	"NA"			""	"baytril,enrofloxacin,enrofloxacine,enrofloxacino,enrofloxacinum,enroxil"					"23712-3,35796-2,35797-0,35798-8"
 "ENV"	135565326	"Enviomycin"	"Antimycobacterials"	"J04AB06"			"tuberactinomycin"	"enviomicina,enviomycin,enviomycina,enviomycinum,tuberactin"					""
 "EPE"		"Eperozolid"	"Other antibacterials"	"NA"			""	""					""
 "EPC"	71392	"Epicillin"	"Beta-lactams/penicillins"	"J01CA07"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"dexacillin,dihydroampicillin,epicilina,epicillin,epicilline,epicillinum"	2	"g"	2	"g"	""
 "EPP"	68916	"Epiroprim"	"Other antibacterials"	"NA"			""	"epiroprim,epiroprima,epiroprime,epiroprimum"					""
-"ERV"	54726192	"Eravacycline"	"Tetracyclines"	"J01AA13"	"Tetracyclines"	"Tetracyclines"	"erav"	"eravacycline,xerava"					""
-"ETP"	150610	"Ertapenem"	"Carbapenems"	"J01DH03"	"Other beta-lactam antibacterials"	"Carbapenems"	"erta,etp"	"ertapenem,invanz"			1	"g"	""
-"ERY"	12560	"Erythromycin"	"Macrolides/lincosamides"	"D10AF02,J01FA01,S01AA17"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"e,em,ery,eryt"	"abboticin,abomacetin,acneryne,acnesol,akne cordes losung,aknederm ery gel,aknemycin,austrias,benzamycin,bristamycin,derimer,deripil,dotycin,dumotrycin,emuvin,emycin,endoeritrin,erecin,erisone,eritomicina,eritrocina,eritromicina,ermycin,eryacne,eryacnen,eryc sprinkles,erycen,erycette,erycin,erycinum,eryderm,erydermer,erygel,eryhexal,erymax,erymed,erypar,erysafe,erytab,erythrocin,erythrocin stearate,erythroderm,erythrogran,erythroguent,erythromid,erythromycin,erythromycin a,erythromycin base,erythromycin lactate,erythromycine,erythromycines,erythromycinum,erytop,erytrociclin,ilocaps,ilosone,iloticina,ilotycin,ilotycin gluceptate,ilotycin t.s.,inderm,inderm gel,indermretcin,latotryd,lederpax,mephamycin,mercina,oftamolets,paediathrocin,pantoderm,pantodrin,pantomicina,pce dispertab,pharyngocin,primacine,propiocine,proterytrin,retcin,robimycin,romycin,sansac,skid gel e,staticin,stiemicyn,stiemycin,theramycin z,tiloryth,tiprocin,torlamicina,udima ery gel,wyamycin s"	2	"g"	1	"g"	"12298-6,16829-4,25275-9,3597-2"
-"ETH"	14052	"Ethambutol"	"Antimycobacterials"	"J04AK02"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"etha"	"aethambutolum,diambutol,ebutol,etambutol,etambutolo,etapiam,ethambutol,ethambutolum,myambutol,mycobutol,purderal,servambutol,tibutol"	1.2	"g"	1.2	"g"	"25404-5,3607-9"
+"ERV"	54726192	"Eravacycline"	"Tetracyclines"	"J01AA13"	"Tetracyclines"	"Tetracyclines"	"erav"	"eravacycline,xerava"					"100049-6,85423-2,93767-2"
+"ETP"	150610	"Ertapenem"	"Carbapenems"	"J01DH03"	"Other beta-lactam antibacterials"	"Carbapenems"	"erta,etp"	"ertapenem,invanz"			1	"g"	"101486-9,35799-6,35800-2,35801-0,35802-8"
+"ERY"	12560	"Erythromycin"	"Macrolides/lincosamides"	"D10AF02,J01FA01,S01AA17"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"e,em,ery,eryt"	"abboticin,abomacetin,acneryne,acnesol,akne cordes losung,aknederm ery gel,aknemycin,austrias,benzamycin,bristamycin,derimer,deripil,dotycin,dumotrycin,emuvin,emycin,endoeritrin,erecin,erisone,eritomicina,eritrocina,eritromicina,ermycin,eryacne,eryacnen,eryc sprinkles,erycen,erycette,erycin,erycinum,eryderm,erydermer,erygel,eryhexal,erymax,erymed,erypar,erysafe,erytab,erythrocin,erythrocin stearate,erythroderm,erythrogran,erythroguent,erythromid,erythromycin,erythromycin a,erythromycin base,erythromycin lactate,erythromycine,erythromycines,erythromycinum,erytop,erytrociclin,ilocaps,ilosone,iloticina,ilotycin,ilotycin gluceptate,ilotycin t.s.,inderm,inderm gel,indermretcin,latotryd,lederpax,mephamycin,mercina,oftamolets,paediathrocin,pantoderm,pantodrin,pantomicina,pce dispertab,pharyngocin,primacine,propiocine,proterytrin,retcin,robimycin,romycin,sansac,skid gel e,staticin,stiemicyn,stiemycin,theramycin z,tiloryth,tiprocin,torlamicina,udima ery gel,wyamycin s"	2	"g"	1	"g"	"100050-4,11576-6,12298-6,16829-4,16830-2,18919-1,18920-9,20380-2,232-9,233-7,234-5,235-2,236-0,23633-1,237-8,238-6,239-4,25224-7,25275-9,3597-2,7009-4"
+"ETH"	14052	"Ethambutol"	"Antimycobacterials"	"J04AK02"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"etha"	"aethambutolum,diambutol,ebutol,etambutol,etambutolo,etapiam,ethambutol,ethambutolum,myambutol,mycobutol,purderal,servambutol,tibutol"	1.2	"g"	1.2	"g"	"100051-2,16841-9,18921-7,20381-0,23625-7,240-2,241-0,242-8,243-6,25187-6,25194-2,25195-9,25230-4,25404-5,3607-9,42645-2,42646-0,55154-9,55674-6,56025-0,7010-2,89491-5"
 "ETI"	456476	"Ethambutol/isoniazid"	"Antimycobacterials"	"J04AM03"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
-"ETI1"	2761171	"Ethionamide"	"Antimycobacterials"	"J04AD03"	"Drugs for treatment of tuberculosis"	"Thiocarbamide derivatives"	"ethi"	"aethionamidum,aetina,aetiva,amidazin,amidazine,ethatyl,ethimide,ethina,ethinamide,ethionamide,ethionamidum,ethioniamide,ethylisothiamide,ethyonomide,etimid,etiocidan,etionamid,etionamida,etionamide,etioniamid,etionid,etionizin,etionizina,etionizine,fatoliamid,iridocin,iridocin bayer,iridozin,isothin,isotiamida,itiocide,nicotion,nisotin,nizotin,rigenicid,sertinon,teberus,thianid,thianide,thioamide,thiodine,thiomid,thioniden,tianid,tiomid,trecator,trecator sc,trekator,trescatyl,trescazide,tubenamide,tubermin,tuberoid,tuberoson"	0.75	"g"			"16845-0"
+"ETI1"	2761171	"Ethionamide"	"Antimycobacterials"	"J04AD03"	"Drugs for treatment of tuberculosis"	"Thiocarbamide derivatives"	"ethi"	"aethionamidum,aetina,aetiva,amidazin,amidazine,ethatyl,ethimide,ethina,ethinamide,ethionamide,ethionamidum,ethioniamide,ethylisothiamide,ethyonomide,etimid,etiocidan,etionamid,etionamida,etionamide,etioniamid,etionid,etionizin,etionizina,etionizine,fatoliamid,iridocin,iridocin bayer,iridozin,isothin,isotiamida,itiocide,nicotion,nisotin,nizotin,rigenicid,sertinon,teberus,thianid,thianide,thioamide,thiodine,thiomid,thioniden,tianid,tiomid,trecator,trecator sc,trekator,trescatyl,trescazide,tubenamide,tubermin,tuberoid,tuberoson"	0.75	"g"			"16099-4,16845-0,18922-5,20382-8,23617-4,25183-5,25196-7,25198-3,25231-2,41693-3,42647-8,42648-6,7011-0,96110-2"
 "ETO"	6034	"Ethopabate"	"Other antibacterials"	"NA"			""	"amprol plus,ethopabat,ethopabate,ethyl pabate"					""
 "EXE"		"Exebacase"		"NA"			""	""					""
-"FAR"	65894	"Faropenem"	"Other antibacterials"	"J01DI03"	"Other beta-lactam antibacterials"	"Other cephalosporins and penems"	""	"faropenem,faropenem sodium,fropenem,fropenum sodium"	0.75	"g"			""
-"FDX"	10034073	"Fidaxomicin"	"Other antibacterials"	"A07AA12"			""	"dificid,dificlir,difimicin,fidaxomicin,lipiarmicin,lipiarmycin,lipiarrmycin,tiacumicin b"	0.4	"g"			""
-"FIN"	11567473	"Finafloxacin"	"Quinolones"	"NA"			""	"finafloxacin"					""
+"FAR"	65894	"Faropenem"	"Other antibacterials"	"J01DI03"	"Other beta-lactam antibacterials"	"Other cephalosporins and penems"	""	"faropenem,faropenem sodium,fropenem,fropenum sodium"	0.75	"g"			"73600-9,73622-3,73645-4"
+"FDX"	10034073	"Fidaxomicin"	"Other antibacterials"	"A07AA12"			""	"dificid,dificlir,difimicin,fidaxomicin,lipiarmicin,lipiarmycin,lipiarrmycin,tiacumicin b"	0.4	"g"			"73599-3,73621-5,73644-7"
+"FIN"	11567473	"Finafloxacin"	"Quinolones"	"NA"			""	"finafloxacin"					"73598-5,73620-7,73643-9"
 "FLA"	46783781	"Flavomycin"	"Other antibacterials"	"NA"			""	"flavophospholipol,moenomycin complex"					""
-"FLE"	3357	"Fleroxacin"	"Quinolones"	"J01MA08"	"Quinolone antibacterials"	"Fluoroquinolones"	"fler"	"fleroxacin,fleroxacine,fleroxacino,fleroxacinum,fleroxicin,megalocin,megalone,megalosin,quinodis"	0.4	"g"	0.4	"g"	""
-"FLO"	65864	"Flomoxef"	"Other antibacterials"	"J01DC14"			""	"flomoxef,flomoxefo,flomoxefum"			2	"g"	""
-"FLR"	114811	"Florfenicol"	"Other antibacterials"	"NA"			""	"aquafen,florfenicol,nuflor,nuflor gold"					"87599-7"
+"FLE"	3357	"Fleroxacin"	"Quinolones"	"J01MA08"	"Quinolone antibacterials"	"Fluoroquinolones"	"fler"	"fleroxacin,fleroxacine,fleroxacino,fleroxacinum,fleroxicin,megalocin,megalone,megalosin,quinodis"	0.4	"g"	0.4	"g"	"25411-0,32372-5,35806-9,7012-8"
+"FLO"	65864	"Flomoxef"	"Other antibacterials"	"J01DC14"			""	"flomoxef,flomoxefo,flomoxefum"			2	"g"	"100052-0,53822-3"
+"FLR"	114811	"Florfenicol"	"Other antibacterials"	"NA"			""	"aquafen,florfenicol,nuflor,nuflor gold"					"23740-4,35807-7,35808-5,87599-7"
 "FLC"	21319	"Flucloxacillin"	"Beta-lactams/penicillins"	"J01CF05"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"clox,flux"	"culpen,floxacillin,floxacillin sodium,floxapen,floxapen sodium salt,fluclox,flucloxacilina,flucloxacillin,flucloxacilline,flucloxacillinum,fluorochloroxacillin,staphylex"	2	"g"	2	"g"	""
-"FLU"	3365	"Fluconazole"	"Antifungals/antimycotics"	"D01AC15,J02AC01"	"Antimycotics for systemic use"	"Triazole derivatives"	"fluc,fluz,flz"	"alflucoz,alfumet,alkanazole,biocanol,biozole,biozolene,canzol,cryptal,diflazon,diflucan,dimycon,elazor,flucazol,fluconazol,fluconazole,fluconazole capsules,fluconazoli,fluconazolum,flucoral,flucostat,flukezol,flunazol,flunizol,flusol,fluzon,fluzone,forcan,fuconal,fungata,loitin,oxifugol,pritenzol,syscan,trican,triconal,triflucan,zoltec"	0.2	"g"	0.2	"g"	"10987-6,16870-8,25255-1,80530-9"
+"FLU"	3365	"Fluconazole"	"Antifungals/antimycotics"	"D01AC15,J02AC01"	"Antimycotics for systemic use"	"Triazole derivatives"	"fluc,fluz,flz"	"alflucoz,alfumet,alkanazole,biocanol,biozole,biozolene,canzol,cryptal,diflazon,diflucan,dimycon,elazor,flucazol,fluconazol,fluconazole,fluconazole capsules,fluconazoli,fluconazolum,flucoral,flucostat,flukezol,flunazol,flunizol,flusol,fluzon,fluzone,forcan,fuconal,fungata,loitin,oxifugol,pritenzol,syscan,trican,triconal,triflucan,zoltec"	0.2	"g"	0.2	"g"	"10987-6,16870-8,18924-1,248-5,249-3,250-1,251-9,25255-1,7013-6,80530-9"
 "FCT"	3366	"Flucytosine"	"Antifungals/antimycotics"	"D01AE21,J02AX01"	"Antifungals for topical use"	"Other antifungals for topical use"	"5flc,fcu,fluo,fluy"	"alcobon,ancoban,ancobon,ancotil,ancotyl,flourocytosine,flucitosina,flucystine,flucytosin,flucytosine,flucytosinum,flucytosone,fluocytosine,fluorcytosine,fluorocytosine"					""
-"FLM"	3374	"Flumequine"	"Quinolones"	"J01MB07"	"Quinolone antibacterials"	"Other quinolones"	""	"apurone,fantacin,flumequine,flumequino,flumequinum,flumigal,flumiquil,flumisol,flumix,imequyl"	1.2	"g"			""
+"FLM"	3374	"Flumequine"	"Quinolones"	"J01MB07"	"Quinolone antibacterials"	"Other quinolones"	""	"apurone,fantacin,flumequine,flumequino,flumequinum,flumigal,flumiquil,flumisol,flumix,imequyl"	1.2	"g"			"55675-3,55676-1,55677-9,55678-7"
 "FLR1"	71260	"Flurithromycin"	"Macrolides/lincosamides"	"J01FA14"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"flurithromicina,flurithromycime,flurithromycin,flurithromycine,flurithromycinum,fluritromicina,fluritromycinum,flurizic"	0.75	"g"			""
 "FFL"	214356	"Fosfluconazole"	"Antifungals/antimycotics"	"NA"			""	"fosfluconazole,phosfluconazole,procif,prodif"					""
-"FOS"	446987	"Fosfomycin"	"Other antibacterials"	"J01XX01"	"Other antibacterials"	"Other antibacterials"	"ff,fm,fo,fof,fos,fosf"	"calcium fosfomycin,fosfocina,fosfomicin,fosfomicina,fosfomycin,fosfomycin sodium,fosfomycine,fosfomycinum,fosfonomycin,infectophos,monuril,monurol,phosphonemycin,phosphonomycin,veramina"	3	"g"	8	"g"	""
+"FOS"	446987	"Fosfomycin"	"Other antibacterials"	"J01XX01"	"Other antibacterials"	"Other antibacterials"	"ff,fm,fo,fof,fos,fosf"	"calcium fosfomycin,fosfocina,fosfomicin,fosfomicina,fosfomycin,fosfomycin sodium,fosfomycine,fosfomycinum,fosfonomycin,infectophos,monuril,monurol,phosphonemycin,phosphonomycin,veramina"	3	"g"	8	"g"	"25596-8,25653-7,35809-3,35810-1"
 "FMD"	572	"Fosmidomycin"	"Other antibacterials"	"NA"			""	"fosmidomycin,fosmidomycina,fosmidomycine,fosmidomycinum"					""
-"FRM"	8378	"Framycetin"	"Aminoglycosides"	"D09AA01,R01AX08,S01AA07"			"fram"	"actilin,actiline,antibiotique,bycomycin,dekamycin iii,endomixin,enterfram,fradiomycin,fradiomycin b,fradiomycinum,framicetina,framidal,framycetin,framycetin sulfate,framycetine,framycetinum,framycin,framygen,francetin,fraquinol,jernadex,myacine,myacyne,mycerin,mycifradin,neobrettin,neolate,neomas,neomcin,neomicina,neomin,neomycin,neomycin b,neomycin b sulfate,neomycin solution,neomycin sulfate,neomycin sulphate,neomycinb,neomycine,neomycinum,nivemycin,pimavecort,soframycin,soframycine,tuttomycin,vonamycin,vonamycin powder v"					""
+"FRM"	8378	"Framycetin"	"Aminoglycosides"	"D09AA01,R01AX08,S01AA07"			"fram"	"actilin,actiline,antibiotique,bycomycin,dekamycin iii,endomixin,enterfram,fradiomycin,fradiomycin b,fradiomycinum,framicetina,framidal,framycetin,framycetin sulfate,framycetine,framycetinum,framycin,framygen,francetin,fraquinol,jernadex,myacine,myacyne,mycerin,mycifradin,neobrettin,neolate,neomas,neomcin,neomicina,neomin,neomycin,neomycin b,neomycin b sulfate,neomycin solution,neomycin sulfate,neomycin sulphate,neomycinb,neomycine,neomycinum,nivemycin,pimavecort,soframycin,soframycine,tuttomycin,vonamycin,vonamycin powder v"					"18926-6,257-6,258-4,259-2,260-0,55679-5"
 "FUR"	6870646	"Furazidin"	"Other antibacterials"	"J01XE03"	"Other antibacterials"	"Nitrofuran derivatives"	""	"akritoin,furagin,furaginum,furamag,furazidin,furazidine"	0.3	"g"			""
-"FRZ"	5323714	"Furazolidone"	"Other antibacterials"	"G01AX06"			""	"bifuron,corizium,coryzium,diafuron,enterotoxon,furall,furaxon,furaxone,furazol,furazolidine,furazolidon,furazolidona,furazolidone,furazolidonum,furazolum,furazon,furidon,furovag,furox aerosol powder,furoxal,furoxane,furoxon,furoxone,furoxone liquid,furoxone swine mix,furozolidine,giardil,giarlam,medaron,neftin,nicolen,nifulidone,nifuran,nifurazolidone,nifurazolidonum,nitrofurazolidone,nitrofurazolidonum,nitrofuroxon,optazol,ortazol,puradin,roptazol,sclaventerol,tikofuran,topazone,trichofuron,tricofuron,tricoron,trifurox,viofuragyn"					""
+"FRZ"	5323714	"Furazolidone"	"Other antibacterials"	"G01AX06"			""	"bifuron,corizium,coryzium,diafuron,enterotoxon,furall,furaxon,furaxone,furazol,furazolidine,furazolidon,furazolidona,furazolidone,furazolidonum,furazolum,furazon,furidon,furovag,furox aerosol powder,furoxal,furoxane,furoxon,furoxone,furoxone liquid,furoxone swine mix,furozolidine,giardil,giarlam,medaron,neftin,nicolen,nifulidone,nifuran,nifurazolidone,nifurazolidonum,nitrofurazolidone,nitrofurazolidonum,nitrofuroxon,optazol,ortazol,puradin,roptazol,sclaventerol,tikofuran,topazone,trichofuron,tricofuron,tricoron,trifurox,viofuragyn"					"69574-2,87794-4"
 "FUS"	3000226	"Fusidic acid"	"Other antibacterials"	"D06AX01,D09AA02,J01XC01,S01AA13"	"Other antibacterials"	"Steroid antibacterials"	"fa,fusi"	"acide fusidique,acido fusidico,acidum fusidicum,flucidin,fucidate,fucidate sodium,fucidic acid,fucidin,fucidin acid,fucithalmic,fusidate,fusidate acid,fusidic acid,fusidicacid,fusidine,fusidinic acid,ramycin,taksta"	1.5	"g"	1.5	"g"	""
-"GAM"	59364992	"Gamithromycin"	"Macrolides/lincosamides"	"NA"			""	"gamithromycin"					""
-"GRN"	124093	"Garenoxacin"	"Quinolones"	"J01MA19"			""	"ganefloxacin,garenfloxacin,garenoxacin"	0.4	"g"			""
-"GAT"	5379	"Gatifloxacin"	"Quinolones"	"J01MA16,S01AE06"	"Quinolone antibacterials"	"Fluoroquinolones"	"gati"	"gatiflo,gatifloxacin,gatifloxacin hydrate,gatifloxacine,gatifloxcin,gatilox,gatiquin,gatispan,tequin,tequin and zymar,zymaxid"	0.4	"g"	0.4	"g"	""
-"GEM"	9571107	"Gemifloxacin"	"Quinolones"	"J01MA15"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"factiv,factive,gemifioxacin,gemifloxacin,gemifloxacine,gemifloxacino,gemifloxacinum"	0.32	"g"			""
-"GEN"	3467	"Gentamicin"	"Aminoglycosides"	"D06AX07,J01GB03,S01AA11,S02AA14,S03AA06"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"cn,gen,gent,gm"	"apogen,centicin,cidomycin,garamycin,garasol,genoptic liquifilm,genoptic s.o.p.,gentacycol,gentafair,gentak,gentamar,gentamcin sulfate,gentamicin,gentamicina,gentamicine,gentamicins,gentamicinum,gentamycin,gentamycins,gentamycinum,gentavet,gentocin,jenamicin,lyramycin,oksitselanim,refobacin,refobacin tm,septigen,uromycine"			0.24	"g"	"13561-6,13562-4,15106-8,22746-2,22747-0,31091-2,31092-0,31093-8,35668-3,3663-2,3664-0,3665-7,39082-3,47109-4,59379-8,80971-5,88111-0"
-"GEH"		"Gentamicin-high"	"Aminoglycosides"	"NA"			"gehi,gehl,genta high,gentamicin high"	""					""
+"GAM"	59364992	"Gamithromycin"	"Macrolides/lincosamides"	"NA"			""	"gamithromycin"					"100054-6,88376-9,88378-5"
+"GRN"	124093	"Garenoxacin"	"Quinolones"	"J01MA19"			""	"ganefloxacin,garenfloxacin,garenoxacin"	0.4	"g"			"35811-9,35812-7,35813-5"
+"GAT"	5379	"Gatifloxacin"	"Quinolones"	"J01MA16,S01AE06"	"Quinolone antibacterials"	"Fluoroquinolones"	"gati"	"gatiflo,gatifloxacin,gatifloxacin hydrate,gatifloxacine,gatifloxcin,gatilox,gatiquin,gatispan,tequin,tequin and zymar,zymaxid"	0.4	"g"	0.4	"g"	"31036-7,31038-3,31040-9,31042-5,41494-6"
+"GEM"	9571107	"Gemifloxacin"	"Quinolones"	"J01MA15"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"factiv,factive,gemifioxacin,gemifloxacin,gemifloxacine,gemifloxacino,gemifloxacinum"	0.32	"g"			"35814-3,35815-0,35816-8,41697-4"
+"GEN"	3467	"Gentamicin"	"Aminoglycosides"	"D06AX07,J01GB03,S01AA11,S02AA14,S03AA06"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"cn,gen,gent,gm"	"apogen,centicin,cidomycin,garamycin,garasol,genoptic liquifilm,genoptic s.o.p.,gentacycol,gentafair,gentak,gentamar,gentamcin sulfate,gentamicin,gentamicina,gentamicine,gentamicins,gentamicinum,gentamycin,gentamycins,gentamycinum,gentavet,gentocin,jenamicin,lyramycin,oksitselanim,refobacin,refobacin tm,septigen,uromycine"			0.24	"g"	"101494-3,13561-6,13562-4,15106-8,18928-2,18929-0,22746-2,22747-0,266-7,267-5,268-3,269-1,31091-2,31092-0,31093-8,35668-3,35817-6,3663-2,3664-0,3665-7,39082-3,47109-4,50630-3,59379-8,7016-9,7017-7,7018-5,80971-5,88111-0,89481-6"
+"GEH"		"Gentamicin-high"	"Aminoglycosides"	"NA"			"gehi,gehl,genta high,gentamicin high"	""					"18929-0,35817-6,7017-7,7018-5"
 "GEP"	25101874	"Gepotidacin"	"Other antibacterials"	"NA"			""	"gepotidacin"					""
-"GRX"	72474	"Grepafloxacin"	"Quinolones"	"J01MA11"	"Quinolone antibacterials"	"Fluoroquinolones"	"grep"	"grepafloxacin"	0.4	"g"			""
-"GRI"	441140	"Griseofulvin"	"Antifungals/antimycotics"	"D01AA08,D01BA01"			""	"amudane,curling factor,delmofulvina,fulcin,fulcine,fulvican grisactin,fulvicin,fulvicin bolus,fulvidex,fulvina,fulvinil,fulvistatin,fungivin,greosin,gresfeed,gricin,grifulin,grifulvin,grifulvin v,grisactin,grisactin ultra,grisactin v,griscofulvin,grise ostatin,grisefuline,griseo,griseoflulvin,griseofulvin,griseofulvin forte,griseofulvina,griseofulvine,griseofulvinum,griseomix,griseostatin,grisetin,grisofulvin,grisovin,grisovin fp,grizeofulvin,grysio,guservin,lamoryl,likuden,likunden,murfulvin,poncyl,spirofulvin,sporostatin xan,xuanjing"	0.5	"g"			"12402-4"
+"GRX"	72474	"Grepafloxacin"	"Quinolones"	"J01MA11"	"Quinolone antibacterials"	"Fluoroquinolones"	"grep"	"grepafloxacin"	0.4	"g"			"21316-5,23638-0,23639-8,35818-4"
+"GRI"	441140	"Griseofulvin"	"Antifungals/antimycotics"	"D01AA08,D01BA01"			""	"amudane,curling factor,delmofulvina,fulcin,fulcine,fulvican grisactin,fulvicin,fulvicin bolus,fulvidex,fulvina,fulvinil,fulvistatin,fungivin,greosin,gresfeed,gricin,grifulin,grifulvin,grifulvin v,grisactin,grisactin ultra,grisactin v,griscofulvin,grise ostatin,grisefuline,griseo,griseoflulvin,griseofulvin,griseofulvin forte,griseofulvina,griseofulvine,griseofulvinum,griseomix,griseostatin,grisetin,grisofulvin,grisovin,grisovin fp,grizeofulvin,grysio,guservin,lamoryl,likuden,likunden,murfulvin,poncyl,spirofulvin,sporostatin xan,xuanjing"	0.5	"g"			"12402-4,54200-1,54201-9,54202-7"
 "HAB"	175989	"Habekacin"	"Aminoglycosides"	"NA"			""	"arbekacin sulfate,arbekacin sulphate,habekacin,habekacin sulfate,habekacin xsulfate,habekacinxsulfate"					""
 "HCH"	11979956	"Hachimycin"	"Antifungals/antimycotics"	"D01AA03,G01AA06,J02AA02"	"Antimycotics for systemic use"	"Antibiotics"	""	"cabimicina,hachimicina,hachimycin,hachimycine,hachimycinum,trichomycinum,trichonat"					""
-"HET"	443387	"Hetacillin"	"Beta-lactams/penicillins"	"J01CA18"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"etacillina,hetacilina,hetacillin,hetacillin acid,hetacilline,hetacillinum,phenazacillin,versapen"	2	"g"			""
+"HET"	443387	"Hetacillin"	"Beta-lactams/penicillins"	"J01CA18"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"etacillina,hetacilina,hetacillin,hetacillin acid,hetacilline,hetacillinum,phenazacillin,versapen"	2	"g"			"18931-6,274-1,275-8,276-6,277-4"
 "HYG"	56928061	"Hygromycin"	"Aminoglycosides"	"NA"			""	"antihelmycin,hydromycin b,hygrovetine"					""
 "IBX"		"Ibrexafungerp"	"Antifungals"	"NA"			""	"ibrexafungerp"					""
-"ICL"	213043	"Iclaprim"	"Other antibacterials"	"J01EA03"			""	"iclaprim,mersarex"					""
-"IPM"	104838	"Imipenem"	"Carbapenems"	"J01DH51"	"Other beta-lactam antibacterials"	"Carbapenems"	"imci,imi,imip,imp"	"imipemide,imipenem,imipenem anhydrous,imipenem hydrate,imipenem/cilastatin,imipenemum,imipenen,primaxin,recarbrio .,tienamycin"			2	"g"	"17010-0,25257-7,27331-8,3688-9"
-"IPE"		"Imipenem/EDTA"	"Carbapenems"	"NA"			""	""					""
-"IMR"		"Imipenem/relebactam"	"Carbapenems"	"NA,J01DH56"			""	""					""
-"ISV"	6918485	"Isavuconazole"	"Antifungals/antimycotics"	"J02AC05"			"isav"	"isavuconazole"	0.2	"g"	0.2	"g"	""
-"ISE"	3037209	"Isepamicin"	"Aminoglycosides"	"J01GB11"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	""	"isepacin,isepalline,isepamicin,isepamicina,isepamicine,isepamicinsulphate,isepamicinum"			0.4	"g"	""
-"ISO"	3760	"Isoconazole"	"Antifungals/antimycotics"	"D01AC05,G01AF07"	"Antimycotics for topic use"	"Triazole derivatives"	""	"isoconazol,isoconazole,isoconazolum,travogen"					""
-"INH"	3767	"Isoniazid"	"Antimycobacterials"	"J04AC01"	"Drugs for treatment of tuberculosis"	"Hydrazides"	"inh"	"abdizide,andrazide,anidrasona,antimicina,antituberkulosum,armacide,armazid,armazide,atcotibine,azt + isoniazid,azuren,bacillin,cemidon,chemiazid,chemidon,continazine,cortinazine,cotinazin,cotinizin,defonin,dianicotyl,dibutin,diforin,dinacrin,ditubin,ebidene,eralon,ertuban,eutizon,evalon,fetefu,fimalene,hid rasonil,hidranizil,hidrasonil,hidrulta,hidrun,hycozid,hydrazid,hydrazide,hyozid,i.a.i.,idrazil,inizid,ipcazide,iscotin,isidrina,ismazide,isobicina,isocid,isocidene,isocotin,isohydrazide,isokin,isolyn,isonerit,isonex,isoniacid,isoniazid,isoniazid sa,isoniazida,isoniazide,isoniazidum,isonicazide,isonicid,isonico,isonicotan,isonicotil,isonicotinhydrazid,isonicotinohydrazide,isonide,isonidrin,isonikazid,isonilex,isonin,isonindon,isonirit,isoniton,isonizida,isonizide,isotamine,isotebe,isotebezid,isotinyl,isozid,isozide,isozyd,laniazid,laniozid,lanizid,mayambutol,mybasan,neoteben,neoxin,neumandin,niadrin,nicazide,nicetal,nicizina,niconyl,nicotibina,nicotibine,nicotisan,nicozide,nidaton,nidrazid,nikozid,niplen,nitadon,niteban,nydrazid,nyscozid,pelazid,percin,phthisen,pycazide,pyreazid,pyricidin,pyridicin,pyrizidin,raumanon,razide,retozide,rifater,rimicid,rimifon,rimiphone,rimitsid,robiselin,robisellin,roxifen,sanohidrazina,sauterazid,sauterzid,stanozide,tebecid,tebenic,tebexin,tebilon,teebaconin,tekazin,tibazide,tibemid,tibiazide,tibinide,tibison,tibivis,tibizide,tibusan,tisiodrazida,tizide,tubazid,tubazide,tubeco,tubecotubercid,tuberian,tubicon,tubilysin,tubizid,tubomel,unicocyde,unicozyde,vazadrine,vederon,zidafimia,zinadon,zonazide"	0.3	"g"	0.3	"g"	"25451-6,26756-7,3697-0,40371-7"
+"ICL"	213043	"Iclaprim"	"Other antibacterials"	"J01EA03"			""	"iclaprim,mersarex"					"73597-7,73619-9,73642-1"
+"IPM"	104838	"Imipenem"	"Carbapenems"	"J01DH51"	"Other beta-lactam antibacterials"	"Carbapenems"	"imci,imi,imip,imp"	"imipemide,imipenem,imipenem anhydrous,imipenem hydrate,imipenem/cilastatin,imipenemum,imipenen,primaxin,recarbrio .,tienamycin"			2	"g"	"101487-7,17010-0,18932-4,18933-2,23613-3,25221-3,25257-7,27331-8,278-2,279-0,280-8,281-6,282-4,283-2,284-0,285-7,35819-2,3688-9,54170-6,54171-4,54172-2,7019-3,85424-0,93232-7,96372-8"
+"IPE"		"Imipenem/EDTA"	"Carbapenems"	"NA"			""	""					"35819-2,54170-6,54171-4,54172-2"
+"IMR"		"Imipenem/relebactam"	"Carbapenems"	"NA,J01DH56"			""	""					"85424-0,93232-7,96372-8"
+"ISV"	6918485	"Isavuconazole"	"Antifungals/antimycotics"	"J02AC05"			"isav"	"isavuconazole"	0.2	"g"	0.2	"g"	"85381-2,88887-5"
+"ISE"	3037209	"Isepamicin"	"Aminoglycosides"	"J01GB11"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	""	"isepacin,isepalline,isepamicin,isepamicina,isepamicine,isepamicinsulphate,isepamicinum"			0.4	"g"	"32381-6,35820-0,35821-8,55680-3"
+"ISO"	3760	"Isoconazole"	"Antifungals/antimycotics"	"D01AC05,G01AF07"	"Antimycotics for topic use"	"Triazole derivatives"	""	"isoconazol,isoconazole,isoconazolum,travogen"					"55681-1,55682-9,55683-7,55684-5"
+"INH"	3767	"Isoniazid"	"Antimycobacterials"	"J04AC01"	"Drugs for treatment of tuberculosis"	"Hydrazides"	"inh"	"abdizide,andrazide,anidrasona,antimicina,antituberkulosum,armacide,armazid,armazide,atcotibine,azt + isoniazid,azuren,bacillin,cemidon,chemiazid,chemidon,continazine,cortinazine,cotinazin,cotinizin,defonin,dianicotyl,dibutin,diforin,dinacrin,ditubin,ebidene,eralon,ertuban,eutizon,evalon,fetefu,fimalene,hid rasonil,hidranizil,hidrasonil,hidrulta,hidrun,hycozid,hydrazid,hydrazide,hyozid,i.a.i.,idrazil,inizid,ipcazide,iscotin,isidrina,ismazide,isobicina,isocid,isocidene,isocotin,isohydrazide,isokin,isolyn,isonerit,isonex,isoniacid,isoniazid,isoniazid sa,isoniazida,isoniazide,isoniazidum,isonicazide,isonicid,isonico,isonicotan,isonicotil,isonicotinhydrazid,isonicotinohydrazide,isonide,isonidrin,isonikazid,isonilex,isonin,isonindon,isonirit,isoniton,isonizida,isonizide,isotamine,isotebe,isotebezid,isotinyl,isozid,isozide,isozyd,laniazid,laniozid,lanizid,mayambutol,mybasan,neoteben,neoxin,neumandin,niadrin,nicazide,nicetal,nicizina,niconyl,nicotibina,nicotibine,nicotisan,nicozide,nidaton,nidrazid,nikozid,niplen,nitadon,niteban,nydrazid,nyscozid,pelazid,percin,phthisen,pycazide,pyreazid,pyricidin,pyridicin,pyrizidin,raumanon,razide,retozide,rifater,rimicid,rimifon,rimiphone,rimitsid,robiselin,robisellin,roxifen,sanohidrazina,sauterazid,sauterzid,stanozide,tebecid,tebenic,tebexin,tebilon,teebaconin,tekazin,tibazide,tibemid,tibiazide,tibinide,tibison,tibivis,tibizide,tibusan,tisiodrazida,tizide,tubazid,tubazide,tubeco,tubecotubercid,tuberian,tubicon,tubilysin,tubizid,tubomel,unicocyde,unicozyde,vazadrine,vederon,zidafimia,zinadon,zonazide"	0.3	"g"	0.3	"g"	"18934-0,20383-6,23947-5,25217-1,25218-9,25219-7,25451-6,26756-7,286-5,287-3,288-1,289-9,29315-9,3697-0,40371-7,42649-4,42650-2,42651-0,45215-1,48171-3,48172-1,55685-2,7020-1,89488-1"
 "IST"		"Isoniazid/sulfamethoxazole/trimethoprim/pyridoxine"	"Antimycobacterials"	"J04AM08"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
-"ITR"	3793	"Itraconazole"	"Antifungals/antimycotics"	"J02AC02"	"Antimycotics for systemic use"	"Triazole derivatives"	"itra"	"intraconazole,itraconazol,itraconazole,itraconazolo,itraconazolum,itraconzaole,itrazole,itrizole,oriconazole,sporanox"	0.2	"g"	0.2	"g"	"10989-2,12392-7,25258-5,27081-9,32184-4,32185-1,80531-7"
-"JOS"	5282165	"Josamycin"	"Macrolides/lincosamides"	"J01FA07"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"jomybel,josacine,josamicina,josamycin,josamycine,josamycinum"	2	"g"			""
-"KAN"	6032	"Kanamycin"	"Aminoglycosides"	"A07AA08,J01GB04,S01AA24"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"hlk,k,kan,kana,km"	"kanamicina,kanamycin,kanamycin a,kanamycin base,kanamycin sulfate,kanamycina,kanamycine,kanamycins,kanamycinum,kantrex,kenamycin a,klebcil,liposomal kanamycin"	3	"g"	1	"g"	"23889-9,3698-8,3699-6,3700-2,47395-9"
-"KAH"		"Kanamycin-high"	"Aminoglycosides"	"NA"			"k_h,kahl"	""					""
+"ITR"	3793	"Itraconazole"	"Antifungals/antimycotics"	"J02AC02"	"Antimycotics for systemic use"	"Triazole derivatives"	"itra"	"intraconazole,itraconazol,itraconazole,itraconazolo,itraconazolum,itraconzaole,itrazole,itrizole,oriconazole,sporanox"	0.2	"g"	0.2	"g"	"10989-2,12392-7,25258-5,25452-4,27081-9,32184-4,32185-1,32603-3,54179-7,7021-9,80531-7"
+"JOS"	5282165	"Josamycin"	"Macrolides/lincosamides"	"J01FA07"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"jomybel,josacine,josamicina,josamycin,josamycine,josamycinum"	2	"g"			"25597-6,25702-2,41698-2,41699-0"
+"KAN"	6032	"Kanamycin"	"Aminoglycosides"	"A07AA08,J01GB04,S01AA24"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"hlk,k,kan,kana,km"	"kanamicina,kanamycin,kanamycin a,kanamycin base,kanamycin sulfate,kanamycina,kanamycine,kanamycins,kanamycinum,kantrex,kenamycin a,klebcil,liposomal kanamycin"	3	"g"	1	"g"	"18935-7,18936-5,23609-1,23889-9,25182-7,25213-0,25214-8,290-7,291-5,292-3,293-1,3698-8,3699-6,3700-2,42652-8,47395-9,49080-5,7022-7,7023-5,7024-3,88002-1,88705-9,89482-4"
+"KAH"		"Kanamycin-high"	"Aminoglycosides"	"NA"			"k_h,kahl"	""					"18936-5,7023-5,7024-3"
 "KAC"		"Kanamycin/cephalexin"	"Aminoglycosides"	"NA"			""	""					""
-"KET"	456201	"Ketoconazole"	"Antifungals/antimycotics"	"D01AC08,G01AF11,H02CA03,J02AB02"	"Antimycotics for systemic use"	"Imidazole derivatives"	"keto,ktc"	"extina,fungarest,fungoral,ketocanazole,ketoconazol,ketoconazole,ketoconazolum,ketoderm,nizoral,xolegel"	0.6	"g"			"10990-0,12393-5,25259-3,60091-6,60092-4"
+"KET"	456201	"Ketoconazole"	"Antifungals/antimycotics"	"D01AC08,G01AF11,H02CA03,J02AB02"	"Antimycotics for systemic use"	"Imidazole derivatives"	"keto,ktc"	"extina,fungarest,fungoral,ketocanazole,ketoconazol,ketoconazole,ketoconazolum,ketoderm,nizoral,xolegel"	0.6	"g"			"10990-0,12393-5,18937-3,25259-3,294-9,295-6,296-4,297-2,60091-6,60092-4,7025-0"
 "KIT"		"Kitasamycin"	"Macrolides/lincosamides"	"NA"			"leucomycin"	"jomybel,josacine,josamicina,josamycin,josamycine,josamycinum"					""
 "LAS"	5360807	"Lasalocid"	"Other antibacterials"	"NA"			""	"avatec,lasalocid,lasalocid a,lasalocide,lasalocide a,lasalocido,lasalocidum"					"87598-9"
 "LSC"	71528768	"Lascufloxacin"	"Quinolones"	"J01MA25"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"lascufloxacin"	75	"mg"			""
 "LTM"	47499	"Latamoxef"	"Cephalosporins (3rd gen.)"	"J01DD06"	"Other beta-lactam antibacterials"	"Third-generation cephalosporins"	"mox,moxa,moxalactam"	"disodium moxalactam,festamoxin,lamoxactam,latamoxef,latamoxefum,moxalactamsupplement,shiomarin"			4	"g"	""
-"LMU"	25185057	"Lefamulin"	"Other antibacterials"	"J01XX12"			""	"lefamulin,xenleta"					""
+"LMU"	25185057	"Lefamulin"	"Other antibacterials"	"J01XX12"			""	"lefamulin,xenleta"					"85425-7,99281-8"
 "LEN"	65646	"Lenampicillin"	"Beta-lactams/penicillins"	"NA"			""	"lenampicilina,lenampicillin,lenampicillin hcl,lenampicilline,lenampicillinum"					""
-"LVX"	149096	"Levofloxacin"	"Quinolones"	"J01MA12,S01AE05"	"Quinolone antibacterials"	"Fluoroquinolones"	"le,lev,levo,lvx"	"aeroquin,anhydrous ofloxacin,cravit,cravit hydrate,cravit iv,cravit ophthalmic,elequine,floxacin,floxel,fluoroquinolone,iquix hydrate,leroxacin,lesacin,levaquin,levaquin hydrate,levo floxacin,levofiexacin,levofloxacin,levofloxacin hydrate,levofloxacine,levofloxacino,levofloxacinum,levokacin,levoxacin,mosardal,nofaxin,ofloxcacin,oftaquix,quinsair,quixin,reskuin,tavanic,unibiotic,venaxan,volequin"	0.5	"g"	0.5	"g"	"21368-6,30532-6,30533-4"
+"LVX"	149096	"Levofloxacin"	"Quinolones"	"J01MA12,S01AE05"	"Quinolone antibacterials"	"Fluoroquinolones"	"le,lev,levo,lvx"	"aeroquin,anhydrous ofloxacin,cravit,cravit hydrate,cravit iv,cravit ophthalmic,elequine,floxacin,floxel,fluoroquinolone,iquix hydrate,leroxacin,lesacin,levaquin,levaquin hydrate,levo floxacin,levofiexacin,levofloxacin,levofloxacin hydrate,levofloxacine,levofloxacino,levofloxacinum,levokacin,levoxacin,mosardal,nofaxin,ofloxcacin,oftaquix,quinsair,quixin,reskuin,tavanic,unibiotic,venaxan,volequin"	0.5	"g"	0.5	"g"	"101501-5,20396-8,20629-2,21367-8,21368-6,30532-6,30533-4,48173-9,53716-7,7026-8,76040-5,76041-3,76042-1"
 "LEO"		"Levofloxacin/ornidazole"	"Other antibacterials"	"J01RA05"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "LND"	9850038	"Levonadifloxacin"	"Quinolones"	"J01MA24"			""	"levonadifloxacin"					""
 "LSP"		"Linco-spectin"	"Other antibacterials"	"NA"			"lincomycin/spectinomycin"	""					""
-"LIN"	3000540	"Lincomycin"	"Macrolides/lincosamides"	"J01FF02"	"Macrolides, lincosamides and streptogramins"	"Lincosamides"	"linc"	"bactramycin,cillimycin,frademicina,jiemycin,lincocin,lincolcina,lincolnensin,lincomicina,lincomycin,lincomycin a,lincomycine,lincomycinum,lincorex"	1.8	"g"	1.8	"g"	"87597-1"
-"LNZ"	441401	"Linezolid"	"Oxazolidinones"	"J01XX08"	"Other antibacterials"	"Other antibacterials"	"line,lnz,lz,lzd"	"linezlid,linezoid,linezolid,linezolide,linezolidum,zivoxid,zyvoxa,zyvoxam,zyvoxid"	1.2	"g"	1.2	"g"	"34202-2,80609-1"
+"LIN"	3000540	"Lincomycin"	"Macrolides/lincosamides"	"J01FF02"	"Macrolides, lincosamides and streptogramins"	"Lincosamides"	"linc"	"bactramycin,cillimycin,frademicina,jiemycin,lincocin,lincolcina,lincolnensin,lincomicina,lincomycin,lincomycin a,lincomycine,lincomycinum,lincorex"	1.8	"g"	1.8	"g"	"18938-1,298-0,299-8,300-4,301-2,41700-6,87597-1"
+"LNZ"	441401	"Linezolid"	"Oxazolidinones"	"J01XX08"	"Other antibacterials"	"Other antibacterials"	"line,lnz,lz,lzd"	"linezlid,linezoid,linezolid,linezolide,linezolidum,zivoxid,zyvoxa,zyvoxam,zyvoxid"	1.2	"g"	1.2	"g"	"29254-0,29255-7,29258-1,33332-8,34202-2,41500-0,80609-1,88706-7,96111-0"
 "LFE"		"Linoprist-flopristin"	"Other antibacterials"	"NA"			""	""					""
-"LOM"	3948	"Lomefloxacin"	"Quinolones"	"J01MA07,S01AE04"	"Quinolone antibacterials"	"Fluoroquinolones"	"lmf,lom,lome"	"lomefloxacin,lomefloxacine,lomefloxacino,lomefloxacinum,maxaquin"	0.4	"g"			""
-"LOR"	5284585	"Loracarbef"	"Cephalosporins (2nd gen.)"	"J01DC08"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"lora"	"anhydrous loracarbef,lorabid,loracabef,loracarbef,loracarbefum,lorbef,loribid"	0.6	"g"			""
-"LYM"	54707177	"Lymecycline"	"Tetracyclines"	"J01AA04"	"Tetracyclines"	"Tetracyclines"	""	"biovetin,chlortetracyclin,ciclisin,ciclolysal,ciclolysine,infaciclina,limeciclina,lisinbiotic,lymecyclin,lymecycline,lymecyclinum,mucomycin,ntetracycline,tetralisal,tetralysal,vebicyclysal"	0.6	"g"	0.6	"g"	""
+"LOM"	3948	"Lomefloxacin"	"Quinolones"	"J01MA07,S01AE04"	"Quinolone antibacterials"	"Fluoroquinolones"	"lmf,lom,lome"	"lomefloxacin,lomefloxacine,lomefloxacino,lomefloxacinum,maxaquin"	0.4	"g"			"18939-9,302-0,303-8,304-6,305-3,41701-4"
+"LOR"	5284585	"Loracarbef"	"Cephalosporins (2nd gen.)"	"J01DC08"	"Other beta-lactam antibacterials"	"Second-generation cephalosporins"	"lora"	"anhydrous loracarbef,lorabid,loracabef,loracarbef,loracarbefum,lorbef,loribid"	0.6	"g"			"18940-7,306-1,307-9,308-7,309-5,7027-6"
+"LYM"	54707177	"Lymecycline"	"Tetracyclines"	"J01AA04"	"Tetracyclines"	"Tetracyclines"	""	"biovetin,chlortetracyclin,ciclisin,ciclolysal,ciclolysine,infaciclina,limeciclina,lisinbiotic,lymecyclin,lymecycline,lymecyclinum,mucomycin,ntetracycline,tetralisal,tetralysal,vebicyclysal"	0.6	"g"	0.6	"g"	"18941-5,310-3,311-1,312-9,313-7"
 "MNA"	1292	"Mandelic acid"	"Other antibacterials"	"B05CA06,J01XX06"	"Other antibacterials"	"Other antibacterials"	""	"acido mandelico,almond acid,ammonium mandelate,amygdalic acid,benzoglycolic acid,hydroxyacetic acid,kyselina mandlova,mandelic acid,paramandelic acid,phenylglycolic acid,uromaline"	12	"g"			""
 "MGX"		"Manogepix"	"Antifungals"	"NA"			""	"manogepix"					""
-"MAR"	60651	"Marbofloxacin"	"Quinolones"	"NA"			""	"marbocyl,marbofloxacin,marbofloxacine,marbofloxacino,marbofloxacinum,zeniquin"					""
+"MAR"	60651	"Marbofloxacin"	"Quinolones"	"NA"			""	"marbocyl,marbofloxacin,marbofloxacine,marbofloxacino,marbofloxacinum,zeniquin"					"73596-9,73618-1,73641-3"
 "MEC"	36273	"Mecillinam"	"Beta-lactams/penicillins"	"J01CA11"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"amdinocillin"	"amdinocillin,coactin,hexacillin,mecilinamo,mecillinam,mecillinamum,micillinam,penicillin hx,selexidin"			1.2	"g"	""
 "MEL"	71306732	"Meleumycin"	"Macrolides/lincosamides"	"NA"			""	""					""
-"MEM"	441130	"Meropenem"	"Carbapenems"	"J01DH02"	"Other beta-lactam antibacterials"	"Carbapenems"	"mem,mer,mero,mp,mrp"	"meronem,meropen,meropenem,meropenem anhydrous,meropenem hydrate,meropenem trihydrate,meropenemum,merrem,merrem i.v.,merrem iv"			3	"g"	"41406-0"
+"MEM"	441130	"Meropenem"	"Carbapenems"	"J01DH02"	"Other beta-lactam antibacterials"	"Carbapenems"	"mem,mer,mero,mp,mrp"	"meronem,meropen,meropenem,meropenem anhydrous,meropenem hydrate,meropenem trihydrate,meropenemum,merrem,merrem i.v.,merrem iv"			3	"g"	"101222-8,101488-5,101489-3,18943-1,41406-0,6651-4,6652-2,6653-0,6654-8,7029-2,85426-5,85427-3,88892-5,90980-4"
 "MNC"		"Meropenem/nacubactam"	"Carbapenems"	"NA"			""	""					""
-"MEV"		"Meropenem/vaborbactam"	"Carbapenems"	"J01DH52"	"Other beta-lactam antibacterials"	"Carbapenems"	""	"carbavance,vabomere"			3	"g"	""
+"MEV"		"Meropenem/vaborbactam"	"Carbapenems"	"J01DH52"	"Other beta-lactam antibacterials"	"Carbapenems"	""	"carbavance,vabomere"			3	"g"	"101222-8,101489-3,85427-3,88892-5,90980-4"
 "MES"	176886	"Mesulfamide"	"Other antibacterials"	"NA"			""	"mesulfamide,mesulfamido,mesulfamidum"					""
 "MTC"	54675785	"Metacycline"	"Tetracyclines"	"J01AA05"	"Tetracyclines"	"Tetracyclines"	""	"bialatan,metaciclina,metacycline,metacyclinum,methacycline,methacycline base,methacyclinum,methylenecycline,physiomycine,rondomycin"	0.6	"g"			""
 "MTM"	6713928	"Metampicillin"	"Beta-lactams/penicillins"	"J01CA14"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"blomopen,bonopen,celinmicina,elatocilline,fedacilina kapseln,filorex,italcina kapseln,magnipen,metabacter ampullen,metambac,metampicilina,metampicillin,metampicillin sodium,metampicillina,metampicilline,metampicillinum,methampicillin,metiskia ampullen,micinovo,micinovo ampullen,pangocilin,probiotic,rastomycin k,relyothenate,ruticina,rutizina,rutizina ampullen,sedomycin,suvipen,suvipen ampullen,tampilen ampullen,teonicon trofen,viderpen,viderpin,vioplex"	1.5	"g"	1.5	"g"	""
@@ -260,63 +260,63 @@
 "MET"	6087	"Meticillin"	"Beta-lactams/penicillins"	"J01CF03"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"meti"	"dimocillin,metacillin,methcilline,methicillin,methicillinum,methycillin,meticilina,meticillin,meticillina,meticilline,meticillinum,staphcillin"			4	"g"	""
 "MTP"	68590	"Metioprim"	"Other antibacterials"	"NA"			""	"methioprim,metioprim,metioprima,metioprime,metioprimum"					""
 "MXT"	3047729	"Metioxate"	"Quinolones"	"NA"			""	"metioxate,metioxato,metioxatum"					""
-"MTR"	4173	"Metronidazole"	"Other antibacterials"	"A01AB17,D06BX01,G01AF01,J01XD01,P01AB01"	"Other antibacterials"	"Imidazole derivatives"	"metr,mnz"	"acromona,anagiardil,arilin,atrivyl,danizol,deflamon,donnan,efloran,elyzol,entizol,flagemona,flagesol,flagil,flagyl,flagyl er,flagyl i.v.,flagyl i.v. rtu,flazol,flegyl,florazole,fossyol,giatricol,ginefla vir,gineflavir,helidac,mepagyl,meronidal,methronidazole,metric,metro cream,metro gel,metro i.v,metro i.v.,metro iv,metrocream,metrodzhil,metrogel,metrogyl,metrolag,metrolotion,metrolyl,metromidol,metronidaz,metronidazol,metronidazole,metronidazole usp,metronidazolo,metronidazolum,metrotop,metrozine,metryl,mexibol,mexibol 'silanes',monagyl,monasin,nidagel,nidagyl,noritate,novonidazol,nuvessa,orvagil,polibiotic,protostat,rathimed,rosased,sanatrichom,satric,takimetol,trichazol,trichex,tricho cordes,trichobrol,trichocide,trichomol,trichopal,trichopol,tricocet,tricom,tricowas b,trikacide,trikamon,trikhopol,trikojol,trikozol,trimeks,trivazol,vagilen,vagimid,vandazole,vertisal,wagitran,zadstat,zidoval"	2	"g"	1.5	"g"	"10991-8"
-"MEZ"	656511	"Mezlocillin"	"Beta-lactams/penicillins"	"J01CA10"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"mez,mezl,mz"	"mezlin,mezlocilina,mezlocillin,mezlocillin acid,mezlocillin sodium,mezlocilline,mezlocillinum,multocillin"			6	"g"	"3820-8"
-"MSU"		"Mezlocillin/sulbactam"	"Beta-lactams/penicillins"	"NA"			""	""					""
-"MIF"	477468	"Micafungin"	"Antifungals/antimycotics"	"J02AX05"	"Antimycotics for systemic use"	"Other antimycotics for systemic use"	"mica"	"micafungin,mycamine"			0.1	"g"	"58418-5"
-"MCZ"	4189	"Miconazole"	"Antifungals/antimycotics"	"A01AB09,A07AC01,D01AC02,G01AF04,J02AB01,S02AA13"	"Antimycotics for systemic use"	"Imidazole derivatives"	"mico"	"aflorix,albistat,andergin,brentan,conofite,dactarin,daktarin,daktarin iv,florid,lotrimin af,micantin,miconasil nitrate,miconazol,miconazole,miconazole base,miconazolo,miconazolum,micozole,minostate,monista,monistat,monistat iv,oravig,vusion,zimybase,zimycan"	0.2	"g"	1	"g"	"17278-3"
+"MTR"	4173	"Metronidazole"	"Other antibacterials"	"A01AB17,D06BX01,G01AF01,J01XD01,P01AB01"	"Other antibacterials"	"Imidazole derivatives"	"metr,mnz"	"acromona,anagiardil,arilin,atrivyl,danizol,deflamon,donnan,efloran,elyzol,entizol,flagemona,flagesol,flagil,flagyl,flagyl er,flagyl i.v.,flagyl i.v. rtu,flazol,flegyl,florazole,fossyol,giatricol,ginefla vir,gineflavir,helidac,mepagyl,meronidal,methronidazole,metric,metro cream,metro gel,metro i.v,metro i.v.,metro iv,metrocream,metrodzhil,metrogel,metrogyl,metrolag,metrolotion,metrolyl,metromidol,metronidaz,metronidazol,metronidazole,metronidazole usp,metronidazolo,metronidazolum,metrotop,metrozine,metryl,mexibol,mexibol 'silanes',monagyl,monasin,nidagel,nidagyl,noritate,novonidazol,nuvessa,orvagil,polibiotic,protostat,rathimed,rosased,sanatrichom,satric,takimetol,trichazol,trichex,tricho cordes,trichobrol,trichocide,trichomol,trichopal,trichopol,tricocet,tricom,tricowas b,trikacide,trikamon,trikhopol,trikojol,trikozol,trimeks,trivazol,vagilen,vagimid,vandazole,vertisal,wagitran,zadstat,zidoval"	2	"g"	1.5	"g"	"10991-8,18946-4,326-9,327-7,328-5,329-3,7031-8"
+"MEZ"	656511	"Mezlocillin"	"Beta-lactams/penicillins"	"J01CA10"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"mez,mezl,mz"	"mezlin,mezlocilina,mezlocillin,mezlocillin acid,mezlocillin sodium,mezlocilline,mezlocillinum,multocillin"			6	"g"	"18947-2,330-1,331-9,332-7,333-5,3820-8,41702-2,54194-6,54195-3,54196-1"
+"MSU"		"Mezlocillin/sulbactam"	"Beta-lactams/penicillins"	"NA"			""	""					"54194-6,54195-3,54196-1"
+"MIF"	477468	"Micafungin"	"Antifungals/antimycotics"	"J02AX05"	"Antimycotics for systemic use"	"Other antimycotics for systemic use"	"mica"	"micafungin,mycamine"			0.1	"g"	"53812-4,58418-5,65340-2,85048-7"
+"MCZ"	4189	"Miconazole"	"Antifungals/antimycotics"	"A01AB09,A07AC01,D01AC02,G01AF04,J02AB01,S02AA13"	"Antimycotics for systemic use"	"Imidazole derivatives"	"mico"	"aflorix,albistat,andergin,brentan,conofite,dactarin,daktarin,daktarin iv,florid,lotrimin af,micantin,miconasil nitrate,miconazol,miconazole,miconazole base,miconazolo,miconazolum,micozole,minostate,monista,monistat,monistat iv,oravig,vusion,zimybase,zimycan"	0.2	"g"	1	"g"	"17278-3,25607-3,25722-0,54180-5,55686-0"
 "MCR"	3037206	"Micronomicin"	"Aminoglycosides"	"S01AA22"			""	"gentamicin c,micromicin,micromycin,micronomicin,micronomicina,micronomicine,micronomicinum,sagamicin,santemycin"					""
 "MID"	5282169	"Midecamycin"	"Macrolides/lincosamides"	"J01FA03"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"aboren,espinomycin a,macropen,madecacine,medemycin,midecamicina,midecamycin,midecamycin a,midecamycine,midecamycinum,midecin,momicine,mydecamycin,myoxam,normicina,rubimycin,turimycin p"	1.2	"g"	1	"g"	""
 "MIL"	37614	"Miloxacin"	"Quinolones"	"NA"			""	"miloxacin,miloxacine,miloxacino,miloxacinum"					""
-"MNO"	54675783	"Minocycline"	"Tetracyclines"	"A01AB23,D10AF07,J01AA08"	"Tetracyclines"	"Tetracyclines"	"mc,mh,mi,min,mino,mn,mno"	"akamin,aknemin,borymycin,dynacin,klinomycin,minociclina,minocin,minocline,minocyclin,minocycline,minocyclinum,minocyn,minoderm,minomycin,sebomin,solodyn,vectrin"	1	"mg"	0.2	"g"	"34606-4,3822-4,49757-8"
-"MCM"	5282188	"Miocamycin"	"Macrolides/lincosamides"	"J01FA11"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"acecamycin,macroral,midecamycin acetate,miocamen,miocamycin,miocamycine,miokamycin,myocamicin,ponsinomycin"	1.2	"g"			""
+"MNO"	54675783	"Minocycline"	"Tetracyclines"	"A01AB23,D10AF07,J01AA08"	"Tetracyclines"	"Tetracyclines"	"mc,mh,mi,min,mino,mn,mno"	"akamin,aknemin,borymycin,dynacin,klinomycin,minociclina,minocin,minocline,minocyclin,minocycline,minocyclinum,minocyn,minoderm,minomycin,sebomin,solodyn,vectrin"	1	"mg"	0.2	"g"	"18948-0,25225-4,334-3,335-0,336-8,337-6,34606-4,3822-4,49757-8,55156-4,7032-6"
+"MCM"	5282188	"Miocamycin"	"Macrolides/lincosamides"	"J01FA11"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"acecamycin,macroral,midecamycin acetate,miocamen,miocamycin,miocamycine,miokamycin,myocamicin,ponsinomycin"	1.2	"g"			"18949-8,338-4,339-2,340-0,341-8,55687-8"
 "MON"	23667299	"Monensin sodium"	"Other antibacterials"	"NA"			""	"monensin sodium,sodium monensin"					""
 "MRN"	70374	"Morinamide"	"Antimycobacterials"	"J04AK04"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	""	"morfazinamide,morfazinammide,morfgazinamide,morinamida,morinamide,morinamide hcl,morinamidum,morphazinamid,morphazinamide,piazofolina,piazolin,piazolina"					""
-"MFX"	152946	"Moxifloxacin"	"Quinolones"	"J01MA14,S01AE07"	"Quinolone antibacterials"	"Fluoroquinolones"	"mox,moxi,mxf"	"actira,avelox,avelox i.v.,avelox iv,avolex,izilox,moxeza,moxifloxacin,moxifloxacine,moxivig,vigamox,zimoxin"	0.4	"g"	0.4	"g"	"43751-7,45223-5,80540-8"
-"MUP"	446596	"Mupirocin"	"Other antibacterials"	"D06AX09,R01AX06"			"mup,mupi"	"bactoderm,bactroban,bactroban nasal,bactroban ointment,centany,mupirocin,mupirocina,mupirocine,mupirocinum,plasimine,pseudomonic acid,pseudomonic acid a,turixin"					""
+"MFX"	152946	"Moxifloxacin"	"Quinolones"	"J01MA14,S01AE07"	"Quinolone antibacterials"	"Fluoroquinolones"	"mox,moxi,mxf"	"actira,avelox,avelox i.v.,avelox iv,avolex,izilox,moxeza,moxifloxacin,moxifloxacine,moxivig,vigamox,zimoxin"	0.4	"g"	0.4	"g"	"31037-5,31039-1,31041-7,31043-3,41502-6,43751-7,45223-5,76043-9,76044-7,76045-4,80540-8,88707-5,93497-6,96112-8"
+"MUP"	446596	"Mupirocin"	"Other antibacterials"	"D06AX09,R01AX06"			"mup,mupi"	"bactoderm,bactroban,bactroban nasal,bactroban ointment,centany,mupirocin,mupirocina,mupirocine,mupirocinum,plasimine,pseudomonic acid,pseudomonic acid a,turixin"					"20389-3,35822-6,35823-4,60542-8,60543-6,7033-4"
 "NAC"	73386748	"Nacubactam"	"Beta-lactams/penicillins"	"NA"			""	"nacubactam"					""
 "NAD"	4410	"Nadifloxacin"	"Quinolones"	"D10AF05"			""	"acuatim,nadifloxacin,nadifloxacine,nadifloxacino,nadifloxacinum,nadixa,nadoxin"					""
-"NAF"	8982	"Nafcillin"	"Beta-lactams/penicillins"	"J01CF06"			""	"nafcilina,nafcillin,nafcillin sodium,nafcilline,nafcillinum,nallpen,naphcillin,unipen"			3	"g"	"10993-4,25232-0"
+"NAF"	8982	"Nafcillin"	"Beta-lactams/penicillins"	"J01CF06"			""	"nafcilina,nafcillin,nafcillin sodium,nafcilline,nafcillinum,nallpen,naphcillin,unipen"			3	"g"	"10993-4,18951-4,25232-0,346-7,347-5,348-3,349-1,41704-8"
 "ZWK"	117587595	"Nafithromycin"	"Macrolides/lincosamides"	"NA"			""	"nafithromycin"					""
 "NAL"	4421	"Nalidixic acid"	"Quinolones"	"J01MB02"	"Quinolone antibacterials"	"Other quinolones"	"na,nal,nali"	"acide nalidixico,acide nalidixique,acido nalidissico,acido nalidixico,acidum nalidixicum,betaxina,dixiben,dixinal,eucisten,eucistin,innoxalomn,innoxalon,jicsron,kusnarin,naldixic acid,nalidic acid,nalidicron,nalidixan,nalidixane,nalidixate,nalidixate sodium,nalidixic,nalidixic acid,nalidixicacid,nalidixin,nalidixinic acid,nalidixinsaure,nalitucsan,nalurin,narigix,naxuril,neggram,negram,nevigramon,nicelate,nogram,poleon,sicmylon,specifen,specifin,unaserus,uralgin,uriben,uriclar,urisal,urodixin,uroman,uroneg,uronidix,uropan,wintomylon,wintron"	4	"g"			""
 "NAR"	65452	"Narasin"	"Other antibacterials"	"NA"			""	"monteban,narasin,narasin a,narasine,narasino,narasinum,narasul"					"87570-8"
 "NEM"	11993740	"Nemonoxacin"	"Quinolones"	"J01MB08"	"Quinolone antibacterials"	"Other quinolones"	""	"nemonoxacin"					""
-"NEO"	8378	"Neomycin"	"Aminoglycosides"	"A01AB08,A07AA01,B05CA09,D06AX04,J01GB05,R02AB01,S01AA03,S02AA07,S03AA01"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"neom"	"actilin,actiline,antibiotique,bycomycin,dekamycin iii,endomixin,enterfram,fradiomycin,fradiomycin b,fradiomycinum,framicetina,framidal,framycetin,framycetin sulfate,framycetine,framycetinum,framycin,framygen,francetin,fraquinol,jernadex,myacine,myacyne,mycerin,mycifradin,neobrettin,neolate,neomas,neomcin,neomicina,neomin,neomycin,neomycin b,neomycin b sulfate,neomycin solution,neomycin sulfate,neomycin sulphate,neomycinb,neomycine,neomycinum,nivemycin,pimavecort,soframycin,soframycine,tuttomycin,vonamycin,vonamycin powder v"	5	"g"			"10995-9,25262-7"
-"NET"	441306	"Netilmicin"	"Aminoglycosides"	"J01GB07,S01AA23"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"neti"	"netillin,netilmicin,netilmicin sulfate,netilmicina,netilmicine,netilmicinum,netilyn,netira,nettacin,vectacin"	0.35	"g"	0.35	"g"	"25263-5,3848-9,3849-7,3850-5,47385-0,59565-2,59566-0,59567-8"
+"NEO"	8378	"Neomycin"	"Aminoglycosides"	"A01AB08,A07AA01,B05CA09,D06AX04,J01GB05,R02AB01,S01AA03,S02AA07,S03AA01"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"neom"	"actilin,actiline,antibiotique,bycomycin,dekamycin iii,endomixin,enterfram,fradiomycin,fradiomycin b,fradiomycinum,framicetina,framidal,framycetin,framycetin sulfate,framycetine,framycetinum,framycin,framygen,francetin,fraquinol,jernadex,myacine,myacyne,mycerin,mycifradin,neobrettin,neolate,neomas,neomcin,neomicina,neomin,neomycin,neomycin b,neomycin b sulfate,neomycin solution,neomycin sulfate,neomycin sulphate,neomycinb,neomycine,neomycinum,nivemycin,pimavecort,soframycin,soframycine,tuttomycin,vonamycin,vonamycin powder v"	5	"g"			"10995-9,18953-0,25262-7,354-1,355-8,356-6,357-4,41705-5"
+"NET"	441306	"Netilmicin"	"Aminoglycosides"	"J01GB07,S01AA23"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"neti"	"netillin,netilmicin,netilmicin sulfate,netilmicina,netilmicine,netilmicinum,netilyn,netira,nettacin,vectacin"	0.35	"g"	0.35	"g"	"18954-8,25263-5,358-2,359-0,360-8,361-6,3848-9,3849-7,3850-5,47385-0,59565-2,59566-0,59567-8,7035-9"
 "NIC"	9507	"Nicarbazin"	"Other antibacterials"	"NA"			""	"nicarb,nicarbasin,nicarbazin,nicarbazine,nicoxin,nicrazin,nicrazine,nirazin"					""
 "NIF"	71946	"Nifuroquine"	"Quinolones"	"NA"			""	"abimasten,nifuroquina,nifuroquine,nifuroquinum,quinaldofur"					""
 "NFR"	9571062	"Nifurtoinol"	"Other antibacterials"	"J01XE02"	"Other antibacterials"	"Nitrofuran derivatives"	""	"levantin,nifurtoinol,nifurtoinolo,nifurtoinolum,urfadin,urfadine,urfadyn"	0.16	"g"			""
-"NTZ"	41684	"Nitazoxanide"	"Other antibacterials"	"P01AX11"			""	"adrovet,alinia,azt + nitazoxanide,colufase,cryptaz,dexidex,heliton,kidonax,nitaxozanid,nitaxozanide,nitazox,nitazoxamide,nitazoxanid,nitazoxanida,nitazoxanide,nitazoxanidum,nitrazoxanide,omniparax,pacovanton,paramix,taenitaz"	1	"g"			""
-"NIT"	6604200	"Nitrofurantoin"	"Other antibacterials"	"J01XE01"	"Other antibacterials"	"Nitrofuran derivatives"	"f,f/m,fd,ft,ni,nit,nitr"	"alfuran,benkfuran,berkfuran,berkfurin,ceduran,chemiofuran,cistofuran,cyantin,cystit,dantafur,fua med,fuamed,furabid,furachel,furadantin,furadantin retard,furadantina mc,furadantine,furadantine mc,furadantoin,furadoin,furadoine,furadonin,furadonine,furadoninum,furadontin,furadoxyl,furalan,furaloid,furantoin,furantoina,furatoin,furedan,furina,furobactina,furodantin,furophen t,gerofuran,io>>uss>>a<<ixoo,ituran,ivadantin,macpac,macrobid,macrodantin,macrodantina,macrofuran,macrofurin,nierofu,nifurantin,nifuretten,nitoin,nitrex,nitrofuradantin,nitrofurantion,nitrofurantoin,nitrofurantoin macro,nitrofurantoina,nitrofurantoine,nitrofurantoinum,novofuran,orafuran,parfuran,phenurin,piyeloseptyl,siraliden,trantoin,uerineks,urantoin,urizept,urodin,urofuran,urofurin,urolisa,urolong,uvamin,welfurin,zoofurin"	0.2	"g"			"3860-4"
-"NIZ"	5447130	"Nitrofurazone"	"Other antibacterials"	"NA"			""	"acutol,aldomycin,alfucin,amifur,babrocid,becafurazone,biofuracina,biofurea,chemofuran,chixin,cocafurin,coxistat,dermofural,dymazone,dynazone,eldezol,fedacin,flavazone,fracine,furacilin,furacilinum,furacillin,furacin,furacine,furacinetten,furacoccid,furacort,furacycline,furaderm,furagent,furalcyn,furaldon,furalone,furametral,furaplast,furaseptyl,furaskin,furatsilin,furaziline,furazin,furazina,furazol w,furazone,furazyme,furesol,furfurin,furosem,fuvacillin,hemofuran,ibiofural,mammex,mastofuran,monafuracin,monafuracis,monofuracin,nfz mix,nifucin,nifurid,nifuzon,nitrofural,nitrofuralum,nitrofuran,nitrofurane,nitrofurazan,nitrofurazone,nitrofurazonum,nitrofurol,nitrozone,otofural,otofuran,rivafurazon,sanfuran,vabrocid,vadrocid,yatrocin"					""
-"NTR"	19910	"Nitroxoline"	"Quinolones"	"J01XX07"	"Other antibacterials"	"Other antibacterials"	""	"galinok,isinok,nibiol,nicene forte,nitroxlina,nitroxolin,nitroxolina,nitroxoline,nitroxolinum,notroxoline,noxibiol"	1	"g"			""
-"NOR"	4539	"Norfloxacin"	"Quinolones"	"J01MA06,S01AE02"	"Quinolone antibacterials"	"Fluoroquinolones"	"nor,norf,nx,nxn"	"baccidal,barazan,chibroxin,chibroxine,chibroxol,fulgram,gonorcin,lexinor,nolicin,noracin,noraxin,norflo,norfloxacin,norfloxacine,norfloxacino,norfloxacinum,norocin,noroxin,noroxine,norxacin,sebercim,uroxacin,utinor,zoroxin"	0.8	"g"			"3867-9"
+"NTZ"	41684	"Nitazoxanide"	"Other antibacterials"	"P01AX11"			""	"adrovet,alinia,azt + nitazoxanide,colufase,cryptaz,dexidex,heliton,kidonax,nitaxozanid,nitaxozanide,nitazox,nitazoxamide,nitazoxanid,nitazoxanida,nitazoxanide,nitazoxanidum,nitrazoxanide,omniparax,pacovanton,paramix,taenitaz"	1	"g"			"73595-1,73617-3,73640-5"
+"NIT"	6604200	"Nitrofurantoin"	"Other antibacterials"	"J01XE01"	"Other antibacterials"	"Nitrofuran derivatives"	"f,f/m,fd,ft,ni,nit,nitr"	"alfuran,benkfuran,berkfuran,berkfurin,ceduran,chemiofuran,cistofuran,cyantin,cystit,dantafur,fua med,fuamed,furabid,furachel,furadantin,furadantin retard,furadantina mc,furadantine,furadantine mc,furadantoin,furadoin,furadoine,furadonin,furadonine,furadoninum,furadontin,furadoxyl,furalan,furaloid,furantoin,furantoina,furatoin,furedan,furina,furobactina,furodantin,furophen t,gerofuran,io>>uss>>a<<ixoo,ituran,ivadantin,macpac,macrobid,macrodantin,macrodantina,macrofuran,macrofurin,nierofu,nifurantin,nifuretten,nitoin,nitrex,nitrofuradantin,nitrofurantion,nitrofurantoin,nitrofurantoin macro,nitrofurantoina,nitrofurantoine,nitrofurantoinum,novofuran,orafuran,parfuran,phenurin,piyeloseptyl,siraliden,trantoin,uerineks,urantoin,urizept,urodin,urofuran,urofurin,urolisa,urolong,uvamin,welfurin,zoofurin"	0.2	"g"			"18955-5,362-4,363-2,364-0,365-7,3860-4,7036-7"
+"NIZ"	5447130	"Nitrofurazone"	"Other antibacterials"	"NA"			""	"acutol,aldomycin,alfucin,amifur,babrocid,becafurazone,biofuracina,biofurea,chemofuran,chixin,cocafurin,coxistat,dermofural,dymazone,dynazone,eldezol,fedacin,flavazone,fracine,furacilin,furacilinum,furacillin,furacin,furacine,furacinetten,furacoccid,furacort,furacycline,furaderm,furagent,furalcyn,furaldon,furalone,furametral,furaplast,furaseptyl,furaskin,furatsilin,furaziline,furazin,furazina,furazol w,furazone,furazyme,furesol,furfurin,furosem,fuvacillin,hemofuran,ibiofural,mammex,mastofuran,monafuracin,monafuracis,monofuracin,nfz mix,nifucin,nifurid,nifuzon,nitrofural,nitrofuralum,nitrofuran,nitrofurane,nitrofurazan,nitrofurazone,nitrofurazonum,nitrofurol,nitrozone,otofural,otofuran,rivafurazon,sanfuran,vabrocid,vadrocid,yatrocin"					"20388-5,87793-6"
+"NTR"	19910	"Nitroxoline"	"Quinolones"	"J01XX07"	"Other antibacterials"	"Other antibacterials"	""	"galinok,isinok,nibiol,nicene forte,nitroxlina,nitroxolin,nitroxolina,nitroxoline,nitroxolinum,notroxoline,noxibiol"	1	"g"			"25608-1,25723-8,32382-4,54181-3,55688-6"
+"NOR"	4539	"Norfloxacin"	"Quinolones"	"J01MA06,S01AE02"	"Quinolone antibacterials"	"Fluoroquinolones"	"nor,norf,nx,nxn"	"baccidal,barazan,chibroxin,chibroxine,chibroxol,fulgram,gonorcin,lexinor,nolicin,noracin,noraxin,norflo,norfloxacin,norfloxacine,norfloxacino,norfloxacinum,norocin,noroxin,noroxine,norxacin,sebercim,uroxacin,utinor,zoroxin"	0.8	"g"			"18956-3,366-5,367-3,368-1,369-9,3867-9,41504-2,7037-5"
 "NME"		"Norfloxacin/metronidazole"	"Other antibacterials"	"J01RA14"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "NTI"		"Norfloxacin/tinidazole"	"Other antibacterials"	"J01RA13"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "NVA"	10419027	"Norvancomycin"	"Glycopeptides"	"NA"			""	"norvancomycin"					""
-"NOV"	54675769	"Novobiocin"	"Other antibacterials"	"NA"			"novo"	"albamix,albamycin,cardelmycin,cathocin,cathomycin,crystallinic acid,inamycin,novobiocin,novobiocina,novobiocine,novobiocinum,robiocina,sirbiocina,spheromycin,stilbiocina,streptonivicin"					"17378-1"
-"NYS"	6433272	"Nystatin"	"Antifungals/antimycotics"	"A07AA02,D01AA01,G01AA01"			"nyst"	"biofanal,candex lotion,comycin,diastatin,herniocid,moronal,myconystatin,mycostatin,mycostatin pastilles,mykinac,mykostatyna,nilstat,nistatin,nistatina,nyamyc,nyotran,nyotrantrade mark,nystaform,nystan,nystatin,nystatin a,nystatin g,nystatin hydrate,nystatin lf,nystatine,nystatinum,nystatyna,nystavescent,nystex,nystop,stamycin,terrastatin,zydin e"	1.5	"MU"			""
-"OFX"	4583	"Ofloxacin"	"Quinolones"	"J01MA01,S01AE01,S02AA16"	"Quinolone antibacterials"	"Fluoroquinolones"	"of,ofl,oflo,ofx"	"bactocin,danoflox,dextrofloxacin,effexin,exocin,exocine,flobacin,flodemex,flotavid,flovid,floxal,floxil,floxin,floxin otic,floxstat,fugacin,inoflox,kinflocin,kinoxacin,levofloxacin hcl,liflox,loxinter,marfloxacin,medofloxine,mergexin,monoflocet,novecin,nufafloqo,occidal,ocuflox,oflocee,oflocet,oflocin,oflodal,oflodex,oflodura,ofloxacin,ofloxacin otic,ofloxacina,ofloxacine,ofloxacino,ofloxacinum,ofloxin,onexacin,operan,orocin,otonil,oxaldin,pharflox,praxin,puiritol,qinolon,quinolon,quotavil,sinflo,tabrin,taravid,tariflox,tarivid,telbit,tructum,uro tarivid,viotisone,visiren,zanocin"	0.4	"g"	0.4	"g"	"25264-3,3877-8"
+"NOV"	54675769	"Novobiocin"	"Other antibacterials"	"NA"			"novo"	"albamix,albamycin,cardelmycin,cathocin,cathomycin,crystallinic acid,inamycin,novobiocin,novobiocina,novobiocine,novobiocinum,robiocina,sirbiocina,spheromycin,stilbiocina,streptonivicin"					"17378-1,18957-1,370-7,371-5,372-3,373-1,41706-3"
+"NYS"	6433272	"Nystatin"	"Antifungals/antimycotics"	"A07AA02,D01AA01,G01AA01"			"nyst"	"biofanal,candex lotion,comycin,diastatin,herniocid,moronal,myconystatin,mycostatin,mycostatin pastilles,mykinac,mykostatyna,nilstat,nistatin,nistatina,nyamyc,nyotran,nyotrantrade mark,nystaform,nystan,nystatin,nystatin a,nystatin g,nystatin hydrate,nystatin lf,nystatine,nystatinum,nystatyna,nystavescent,nystex,nystop,stamycin,terrastatin,zydin e"	1.5	"MU"			"10697-1,10698-9,18958-9,35824-2,55689-4"
+"OFX"	4583	"Ofloxacin"	"Quinolones"	"J01MA01,S01AE01,S02AA16"	"Quinolone antibacterials"	"Fluoroquinolones"	"of,ofl,oflo,ofx"	"bactocin,danoflox,dextrofloxacin,effexin,exocin,exocine,flobacin,flodemex,flotavid,flovid,floxal,floxil,floxin,floxin otic,floxstat,fugacin,inoflox,kinflocin,kinoxacin,levofloxacin hcl,liflox,loxinter,marfloxacin,medofloxine,mergexin,monoflocet,novecin,nufafloqo,occidal,ocuflox,oflocee,oflocet,oflocin,oflodal,oflodex,oflodura,ofloxacin,ofloxacin otic,ofloxacina,ofloxacine,ofloxacino,ofloxacinum,ofloxin,onexacin,operan,orocin,otonil,oxaldin,pharflox,praxin,puiritol,qinolon,quinolon,quotavil,sinflo,tabrin,taravid,tariflox,tarivid,telbit,tructum,uro tarivid,viotisone,visiren,zanocin"	0.4	"g"	0.4	"g"	"18959-7,20384-4,23948-3,25264-3,374-9,375-6,376-4,377-2,3877-8,41408-6,41409-4,41410-2,42653-6,7038-3,72168-8"
 "OOR"		"Ofloxacin/ornidazole"	"Other antibacterials"	"J01RA09"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
-"OLE"	72493	"Oleandomycin"	"Macrolides/lincosamides"	"J01FA05"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"amimycin,landomycin,matromycin,oleandomicina,oleandomycin,oleandomycin a,oleandomycine,oleandomycinum,romicil"	1	"g"			""
-"OMC"	54697325	"Omadacycline"	"Tetracyclines"	"J01AA15"			""	"amadacycline,omadacycline"	0.3	"g"	0.1	"g"	""
-"OPT"	87880	"Optochin"	"Other antibacterials"	"NA"			""	"numoquin,optochin,optoquine"					""
-"ORB"	60605	"Orbifloxacin"	"Quinolones"	"NA"			""	"orbifloxacin"					""
-"ORI"	16136912	"Oritavancin"	"Glycopeptides"	"J01XA05"	"Other antibacterials"	"Glycopeptide antibacterials"	"orit"	"kimyrsa,oritavancin"					""
-"ORS"		"Ormetroprim/sulfamethoxazole"	"Other antibacterials"	"NA"			""	""					""
-"ORN"	28061	"Ornidazole"	"Other antibacterials"	"G01AF06,J01XD03,P01AB03"	"Other antibacterials"	"Imidazole derivatives"	""	"madelen,ornidal,ornidazol,ornidazole,ornidazolum,tiberal"	1.5	"g"	1	"g"	""
+"OLE"	72493	"Oleandomycin"	"Macrolides/lincosamides"	"J01FA05"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"amimycin,landomycin,matromycin,oleandomicina,oleandomycin,oleandomycin a,oleandomycine,oleandomycinum,romicil"	1	"g"			"18960-5,378-0,379-8,380-6,381-4,55690-2"
+"OMC"	54697325	"Omadacycline"	"Tetracyclines"	"J01AA15"			""	"amadacycline,omadacycline"	0.3	"g"	0.1	"g"	"73594-4,73616-5,73639-7"
+"OPT"	87880	"Optochin"	"Other antibacterials"	"NA"			""	"numoquin,optochin,optoquine"					"100055-3,73665-2"
+"ORB"	60605	"Orbifloxacin"	"Quinolones"	"NA"			""	"orbifloxacin"					"35825-9,35826-7,35827-5"
+"ORI"	16136912	"Oritavancin"	"Glycopeptides"	"J01XA05"	"Other antibacterials"	"Glycopeptide antibacterials"	"orit"	"kimyrsa,oritavancin"					"41707-1,41708-9,41709-7,41736-0"
+"ORS"		"Ormetroprim/sulfamethoxazole"	"Other antibacterials"	"NA"			""	""					"73593-6,73615-7,73638-9"
+"ORN"	28061	"Ornidazole"	"Other antibacterials"	"G01AF06,J01XD03,P01AB03"	"Other antibacterials"	"Imidazole derivatives"	""	"madelen,ornidal,ornidazol,ornidazole,ornidazolum,tiberal"	1.5	"g"	1	"g"	"55691-0,55692-8,55693-6,55694-4"
 "OTE"	77050711	"Oteseconazole"	"Antifungals/antimycotics"	"J02AC06"	"Antimycotics for systemic use"	"Triazole derivatives"	""	"oteseconazole"					""
-"OXA"	6196	"Oxacillin"	"Beta-lactams/penicillins"	"J01CF04"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"ox,oxa,oxac,oxal,oxs"	"bactocill,ossacillina,oxacilina,oxacillin,oxacillin sodium,oxacilline,oxacillinum,oxazocillin,oxazocilline,prostaphlin,prostaphlyn,sodium oxacillin"	2	"g"	2	"g"	"25265-0,3882-8"
+"OXA"	6196	"Oxacillin"	"Beta-lactams/penicillins"	"J01CF04"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase resistant penicillins"	"ox,oxa,oxac,oxal,oxs"	"bactocill,ossacillina,oxacilina,oxacillin,oxacillin sodium,oxacilline,oxacillinum,oxazocillin,oxazocilline,prostaphlin,prostaphlyn,sodium oxacillin"	2	"g"	2	"g"	"18961-3,25265-0,382-2,383-0,384-8,385-5,3882-8,7039-1"
 "OXO"	4628	"Oxolinic acid"	"Quinolones"	"J01MB05"	"Quinolone antibacterials"	"Other quinolones"	""	"acide oxolinique,acido ossolico,acido oxolinico,acidum oxolinicum,aqualinic,cistopax,dioxacin,emyrenil,gramurin,inoxyl,nidantin,oksaren,orthurine,ossian,oxoboi,oxolinic,oxolinic acid,pietil,prodoxal,prodoxol,starner,tiurasin,ultibid,urinox,uritrate,urotrate,uroxol,utibid"	1	"g"			""
-"OXY"	54675779	"Oxytetracycline"	"Tetracyclines"	"D06AA03,G01AA07,J01AA06,S01AA04"	"Tetracyclines"	"Tetracyclines"	""	"adamycin,berkmycen,biostat,biostat pa,bisolvomycin,dabicycline,dalimycin,embryostat,fanterrin,galsenomycin,geomycin,geotilin,hydroxytetracyclinum,imperacin,lenocycline,macocyn,medamycin,mepatar,oksisyklin,ossitetraciclina,oxacycline,oxitetraciclina,oxitetracyclin,oxitetracycline,oxitetracyclinum,oxydon,oxymycin,oxymykoin,oxypam,oxysteclin,oxyterracin,oxyterracine,oxyterracyne,oxytetracid,oxytetracyclin,oxytetracycline,oxytetracycline base,oxytetracyclinum,proteroxyna,riomitsin,ryomycin,solkaciclina,stecsolin,stevacin,tarocyn,tarosin,teravit,terrafungine,terramitsin,terramycin,terramycin im,terramycine,tetran,unimycin,ursocyclin,ursocycline,vendarcin"	1	"g"	1	"g"	"17396-3,25266-8,87595-5"
+"OXY"	54675779	"Oxytetracycline"	"Tetracyclines"	"D06AA03,G01AA07,J01AA06,S01AA04"	"Tetracyclines"	"Tetracyclines"	""	"adamycin,berkmycen,biostat,biostat pa,bisolvomycin,dabicycline,dalimycin,embryostat,fanterrin,galsenomycin,geomycin,geotilin,hydroxytetracyclinum,imperacin,lenocycline,macocyn,medamycin,mepatar,oksisyklin,ossitetraciclina,oxacycline,oxitetraciclina,oxitetracyclin,oxitetracycline,oxitetracyclinum,oxydon,oxymycin,oxymykoin,oxypam,oxysteclin,oxyterracin,oxyterracine,oxyterracyne,oxytetracid,oxytetracyclin,oxytetracycline,oxytetracycline base,oxytetracyclinum,proteroxyna,riomitsin,ryomycin,solkaciclina,stecsolin,stevacin,tarocyn,tarosin,teravit,terrafungine,terramitsin,terramycin,terramycin im,terramycine,tetran,unimycin,ursocyclin,ursocycline,vendarcin"	1	"g"	1	"g"	"17396-3,18962-1,25266-8,386-3,387-1,388-9,389-7,55699-3,87595-5"
 "OZN"		"Ozenoxacin"		"D06AX14"			""	"ozadub,ozenoxacin,ozenoxacin cream"					""
 "PAS"	4649	"P-aminosalicylic acid"	"Antimycobacterials"	"NA"			""	"aminopar,aminosalicylic,aminosalicylic acid,aminosalyl,aminox,apacil,deapasil,entepas,ferrosan,gabbropas,granupas,helipidyl,hellipidyl,neopasalate,osacyl,pamacyl,pamisyl,paramycin,parasal,parasalicil,parasalindon,pasalon,pasara,pascorbic,pasdium,paser granules,paskalium,pasmed,pasnodia,pasolac,propasa,rezipas,teebacin"					""
-"PAN"	72015	"Panipenem"	"Carbapenems"	"NA,J01DH55"			""	"panipenem,panipenem/betamipron,panipenemum,penipanem"					""
-"PAR"	165580	"Paromomycin"	"Other antibacterials"	"A07AA06"			""	"aminosidin,aminosidine,aminosidine i,aminosidine sulfate,amminosidin,crestomycin,estomycin,gabbromicina,gabbromycin,gabromycin,humatin,humycin,hydroxymycin,hydroxymycin sulfate,monomycin,monomycin a,neomycin e,paramomycin,paramomycin sulfate,paromomicina,paromomycin,paromomycin i,paromomycine,paromomycinum,paucimycin,paucimycinum,quintomycin c"	3	"g"			""
+"PAN"	72015	"Panipenem"	"Carbapenems"	"NA,J01DH55"			""	"panipenem,panipenem/betamipron,panipenemum,penipanem"					"100056-1,53823-1"
+"PAR"	165580	"Paromomycin"	"Other antibacterials"	"A07AA06"			""	"aminosidin,aminosidine,aminosidine i,aminosidine sulfate,amminosidin,crestomycin,estomycin,gabbromicina,gabbromycin,gabromycin,humatin,humycin,hydroxymycin,hydroxymycin sulfate,monomycin,monomycin a,neomycin e,paramomycin,paramomycin sulfate,paromomicina,paromomycin,paromomycin i,paromomycine,paromomycinum,paucimycin,paucimycinum,quintomycin c"	3	"g"			"51719-3,53824-9,55700-9,55701-7,55702-5"
 "PAZ"	65957	"Pazufloxacin"	"Quinolones"	"J01MA18"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"pazufloxacin,pazufloxacine,pazufloxacino,pazufloxacinum"			1	"g"	""
-"PEF"	51081	"Pefloxacin"	"Quinolones"	"J01MA03"	"Quinolone antibacterials"	"Fluoroquinolones"	"pefl"	"abactal,labocton,pefloxacin,pefloxacine,pefloxacinium,pefloxacino,pefloxacinum,perfloxacin,silver pefloxacin"	0.8	"g"	0.8	"g"	"3906-5"
+"PEF"	51081	"Pefloxacin"	"Quinolones"	"J01MA03"	"Quinolone antibacterials"	"Fluoroquinolones"	"pefl"	"abactal,labocton,pefloxacin,pefloxacine,pefloxacinium,pefloxacino,pefloxacinum,perfloxacin,silver pefloxacin"	0.8	"g"	0.8	"g"	"18963-9,35828-3,390-5,3906-5,7040-9"
 "PNM"	10250769	"Penamecillin"	"Beta-lactams/penicillins"	"J01CE06"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	""	"hydroxymethyl,penamecilina,penamecillin,penamecillina,penamecilline,penamecillinum"	1.05	"g"			""
-"PNO"		"Penicillin/novobiocin"	"Beta-lactams/penicillins"	"NA"			""	""					""
+"PNO"		"Penicillin/novobiocin"	"Beta-lactams/penicillins"	"NA"			""	""					"35872-1,35873-9,35874-7"
 "PSU"		"Penicillin/sulbactam"	"Beta-lactams/penicillins"	"NA"			""	""					""
 "PNM1"	54686187	"Penimepicycline"	"Tetracyclines"	"J01AA10"	"Tetracyclines"	"Tetracyclines"	""	"criseocil,duamine,geotricyn,hydrocycline,penetracyne,penimepiciclina,penimepicycline,penimepicyclinum"					""
 "PIM"	65453	"Pentisomicin"	"Aminoglycosides"	"NA"			""	"pentisomicin,pentisomicina,pentisomicine,pentisomicinum"					""
@@ -326,80 +326,80 @@
 "PHN"	6869	"Phenoxymethylpenicillin"	"Beta-lactams/penicillins"	"J01CE02"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	"fepe,peni v,penicillin v,pnv,pv"	"acipen v,apocillin,apopen,beromycin,calcipen,compocillin v,crystapen v,distaquaine v,eskacillian v,eskacillin v,fenacilin,fenospen,meropenin,oracillin,oratren,pc pen vk,penicillin v,penicillinv,phenocillin,phenomycilline,phenopenicillin,robicillin,rocilin,stabicillin,vebecillin,veetids,vegacillin"	2	"g"			""
 "PMR"	5284447	"Pimaricin"	"Antifungals/antimycotics"	"NA"			"natamycin"	"delvocid,delvolan,delvopos,mycophyt,myprozine,natacyn,natafucin,natamicina,natamycin,natamycine,natamycinum,pimafucin,pimaracin,pimaricin,pimaricine,pimarizin,synogil,tennecetin"					""
 "PPA"	4831	"Pipemidic acid"	"Quinolones"	"J01MB04"	"Quinolone antibacterials"	"Other quinolones"	"pipz,pizu"	"acide pipemidique,acido pipemidico,acidum pipemidicum,deblaston,dolcol,filtrax,pipedac,pipemid,pipemidate,pipemidic,pipemidic acid,pipemidicacid,pipram,pipurin,tractur,uromidin,urosten,uroval"	0.8	"g"			""
-"PIP"	43672	"Piperacillin"	"Beta-lactams/penicillins"	"J01CA12"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"pi,pip,pipc,pipe,pp"	"isipen,pentcillin,peperacillin,peracin,piperacilina,piperacillin,piperacillin hydrate,piperacillin na,piperacillin sodium,piperacillina,piperacilline,piperacillinum,pipercillin,pipracil,pipril,tazocin"			14	"g"	"25268-4,3972-7"
-"PIS"		"Piperacillin/sulbactam"	"Beta-lactams/penicillins"	"NA"			""	""					""
-"TZP"	461573	"Piperacillin/tazobactam"	"Beta-lactams/penicillins"	"J01CR05"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	"p/t,piptaz,piptazo,pit,pita,pt,ptc,ptz,tzp"	"tazocel,tazocillin,tazocin,zosyn"			14	"g"	""
+"PIP"	43672	"Piperacillin"	"Beta-lactams/penicillins"	"J01CA12"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"pi,pip,pipc,pipe,pp"	"isipen,pentcillin,peperacillin,peracin,piperacilina,piperacillin,piperacillin hydrate,piperacillin na,piperacillin sodium,piperacillina,piperacilline,piperacillinum,pipercillin,pipracil,pipril,tazocin"			14	"g"	"101490-1,101491-9,18969-6,18970-4,25268-4,3972-7,407-7,408-5,409-3,410-1,411-9,412-7,413-5,414-3,54197-9,54198-7,54199-5,55704-1,7043-3,7044-1"
+"PIS"		"Piperacillin/sulbactam"	"Beta-lactams/penicillins"	"NA"			""	""					"54197-9,54198-7,54199-5,55704-1"
+"TZP"	461573	"Piperacillin/tazobactam"	"Beta-lactams/penicillins"	"J01CR05"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	"p/t,piptaz,piptazo,pit,pita,pt,ptc,ptz,tzp"	"tazocel,tazocillin,tazocin,zosyn"			14	"g"	"101491-9,18970-4,411-9,412-7,413-5,414-3,7044-1"
 "PRC"	71978	"Piridicillin"	"Beta-lactams/penicillins"	"NA"			""	"piridicillin"					""
-"PRL"	157385	"Pirlimycin"	"Macrolides/lincosamides"	"NA"			""	"pirlimycin,pirlimycina,pirlimycine,pirlimycinum,pirsue"					""
+"PRL"	157385	"Pirlimycin"	"Macrolides/lincosamides"	"NA"			""	"pirlimycin,pirlimycina,pirlimycine,pirlimycinum,pirsue"					"35829-1,35830-9,35831-7"
 "PIR"	4855	"Piromidic acid"	"Quinolones"	"J01MB03"	"Quinolone antibacterials"	"Other quinolones"	""	"acide piromidique,acido piromidico,acidum piromidicum,actrun c,bactramyl,enterol,gastrurol,panacid,pirodal,piromidate,piromidic acid,piromidicacid,pyrido,reelon,septural,urisept,uropir,zaomeal"	2	"g"			""
-"PVM"	33478	"Pivampicillin"	"Beta-lactams/penicillins"	"J01CA02"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"berocillin,pivaloylampicillin,pivampicilina,pivampicillin,pivampicilline,pivampicillinum,pondocillin"	1.05	"g"			""
+"PVM"	33478	"Pivampicillin"	"Beta-lactams/penicillins"	"J01CA02"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"berocillin,pivaloylampicillin,pivampicilina,pivampicillin,pivampicilline,pivampicillinum,pondocillin"	1.05	"g"			"18971-2,415-0,416-8,417-6,418-4"
 "PME"	115163	"Pivmecillinam"	"Beta-lactams/penicillins"	"J01CA08"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"amdinocillin pivoxil,coactabs,hydroxymethyl,pivmecilinamo,pivmecillinam,pivmecillinam hcl,pivmecillinamum"	0.6	"g"			""
-"PLZ"	42613186	"Plazomicin"	"Aminoglycosides"	"J01GB14"			""	"plazomicin,zemdri"					"92024-9"
-"PLB"	49800004	"Polymyxin B"	"Polymyxins"	"A07AA05,J01XB02,S01AA18,S02AA11,S03AA03"	"Other antibacterials"	"Polymyxins"	"pb,pol,polb,poly,poly b,polymixin,polymixin b"	"polimixina b,polumyxin b,polymixin b,polymyxine b"	3	"MU"	0.15	"g"	"17473-0,25269-2"
+"PLZ"	42613186	"Plazomicin"	"Aminoglycosides"	"J01GB14"			""	"plazomicin,zemdri"					"73592-8,73614-0,73637-1,92024-9,94719-2"
+"PLB"	49800004	"Polymyxin B"	"Polymyxins"	"A07AA05,J01XB02,S01AA18,S02AA11,S03AA03"	"Other antibacterials"	"Polymyxins"	"pb,pol,polb,poly,poly b,polymixin,polymixin b"	"polimixina b,polumyxin b,polymixin b,polymyxine b"	3	"MU"	0.15	"g"	"17473-0,18972-0,25269-2,35832-5,419-2,420-0,421-8,422-6"
 "POP"		"Polymyxin B/polysorbate 80"	"Polymyxins"	"NA"			""	""					""
-"POS"	468595	"Posaconazole"	"Antifungals/antimycotics"	"J02AC04"	"Antimycotics for systemic use"	"Triazole derivatives"	"posa"	"noxafil,posaconazole,posaconazole sp,posconazole"	0.3	"g"	0.3	"g"	"53731-6,80545-7"
-"PRA"	9802884	"Pradofloxacin"	"Quinolones"	"NA"			""	"pradofloxacin,pudofloxacin,veraflox"					""
-"PRX"	71455	"Premafloxacin"	"Quinolones"	"NA"			""	"premafloxacin,remafloxacin"					""
-"PMD"	456199	"Pretomanid"	"Antimycobacterials"	"J04AK08"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	""	"oxazine,pretomanid"					""
+"POS"	468595	"Posaconazole"	"Antifungals/antimycotics"	"J02AC04"	"Antimycotics for systemic use"	"Triazole derivatives"	"posa"	"noxafil,posaconazole,posaconazole sp,posconazole"	0.3	"g"	0.3	"g"	"53731-6,54186-2,54187-0,54188-8,54189-6,80545-7"
+"PRA"	9802884	"Pradofloxacin"	"Quinolones"	"NA"			""	"pradofloxacin,pudofloxacin,veraflox"					"76148-6,87800-9"
+"PRX"	71455	"Premafloxacin"	"Quinolones"	"NA"			""	"premafloxacin,remafloxacin"					"73591-0,73613-2,73636-3"
+"PMD"	456199	"Pretomanid"	"Antimycobacterials"	"J04AK08"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	""	"oxazine,pretomanid"					"93850-6"
 "PRM"	6446787	"Primycin"	"Macrolides/lincosamides"	"NA"			""	"primycin"					""
-"PRI"	11979535	"Pristinamycin"	"Macrolides/lincosamides"	"J01FG01"	"Macrolides, lincosamides and streptogramins"	"Streptogramins"	"pris"	"eskalin v,mikamycin,mikamycine,mikamycinum,ostreogrycinum,pristinamycine,pristinamycinum,stafac,stafytracine,staphylomycin,starfac,streptogramin,vernamycin,virgimycin,virgimycine,virginiamycin,virginiamycina,virginiamycine,virginiamycinum"	2	"g"			""
+"PRI"	11979535	"Pristinamycin"	"Macrolides/lincosamides"	"J01FG01"	"Macrolides, lincosamides and streptogramins"	"Streptogramins"	"pris"	"eskalin v,mikamycin,mikamycine,mikamycinum,ostreogrycinum,pristinamycine,pristinamycinum,stafac,stafytracine,staphylomycin,starfac,streptogramin,vernamycin,virgimycin,virgimycine,virginiamycin,virginiamycina,virginiamycine,virginiamycinum"	2	"g"			"32383-2,35833-3,35834-1,55709-0"
 "PRB"	5903	"Procaine benzylpenicillin"	"Beta-lactams/penicillins"	"J01CE09"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	""	"depocillin,duphapen,hostacillin,hydracillin,jenacillin o,nopcaine,penicillin procaine,retardillin,vetspen,vitablend"			0.6	"g"	""
 "PRP"	92879	"Propicillin"	"Beta-lactams/penicillins"	"J01CE03"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase sensitive penicillins"	""	"propicilina,propicillin,propicilline,propicillinum"	0.9	"g"			""
 "PKA"	9872451	"Propikacin"	"Aminoglycosides"	"NA"			""	"propikacin,propikacina,propikacine,propikacinum"					""
 "PTH"	666418	"Protionamide"	"Antimycobacterials"	"J04AD01"	"Drugs for treatment of tuberculosis"	"Thiocarbamide derivatives"	"prot"	"ektebin,peteha,prothionamide,prothionamidum,protion,protionamid,protionamida,protionamide,protionamidum,protionizina,tebeform,trevintix,tuberex"	0.75	"g"			""
-"PRU"	65947	"Prulifloxacin"	"Quinolones"	"J01MA17"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"prulifloxacin,pruvel,pufloxacin dioxolil,quisnon"	0.6	"g"			""
-"PZA"	1046	"Pyrazinamide"	"Antimycobacterials"	"J04AK01"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"pyra"	"aldinamid,aldinamide,braccopiral,corsazinmid,dipimide,eprazin,farmizina,isopas,lynamide,novamid,p ezetamid,pezetamid,pharozinamide,piraldina,pirazimida,pirazinamid,pirazinamida,pirazinamide,prazina,pyrafat,pyramide,pyrazide,pyrazinamdie,pyrazinamid,pyrazinamide,pyrazinamidum,pyrazine carboxamide,pyrazineamide,pyrizinamide,rifafour,rozide,tebrazid,tebrazio,tisamid,unipyranamide,zinamide,zinastat"	1.5	"g"			"11001-5,25270-0"
-"QDA"	11979418	"Quinupristin/dalfopristin"	"Macrolides/lincosamides"	"J01FG02"	"Macrolides, lincosamides and streptogramins"	"Streptogramins"	"q/d,qda,qida,quda,rp,syn"	""			1.5	"g"	""
+"PRU"	65947	"Prulifloxacin"	"Quinolones"	"J01MA17"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"prulifloxacin,pruvel,pufloxacin dioxolil,quisnon"	0.6	"g"			"100058-7,76145-2"
+"PZA"	1046	"Pyrazinamide"	"Antimycobacterials"	"J04AK01"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"pyra"	"aldinamid,aldinamide,braccopiral,corsazinmid,dipimide,eprazin,farmizina,isopas,lynamide,novamid,p ezetamid,pezetamid,pharozinamide,piraldina,pirazimida,pirazinamid,pirazinamida,pirazinamide,prazina,pyrafat,pyramide,pyrazide,pyrazinamdie,pyrazinamid,pyrazinamide,pyrazinamidum,pyrazine carboxamide,pyrazineamide,pyrizinamide,rifafour,rozide,tebrazid,tebrazio,tisamid,unipyranamide,zinamide,zinastat"	1.5	"g"			"11001-5,18973-8,20461-0,23632-3,25186-8,25229-6,25270-0,423-4,424-2,425-9,426-7,42935-7,55710-8,55711-6,56026-8,92242-7"
+"QDA"	11979418	"Quinupristin/dalfopristin"	"Macrolides/lincosamides"	"J01FG02"	"Macrolides, lincosamides and streptogramins"	"Streptogramins"	"q/d,qda,qida,quda,rp,syn"	""			1.5	"g"	"23640-6,23641-4,33334-4,35835-8,58712-1"
 "RAC"	56052	"Ractopamine"	"Other antibacterials"	"NA"			""	"optaflexx,paylean,ractopamina,ractopamine,ractopaminum"					""
-"RAM"	16132338	"Ramoplanin"	"Glycopeptides"	"NA"			""	"ramoplanin"					""
-"RZM"	10993211	"Razupenem"	"Carbapenems"	"NA"			""	"razupenem"					""
+"RAM"	16132338	"Ramoplanin"	"Glycopeptides"	"NA"			""	"ramoplanin"					"41710-5,41711-3,41712-1,41737-8"
+"RZM"	10993211	"Razupenem"	"Carbapenems"	"NA"			""	"razupenem"					"73590-2,73612-4,73635-5"
 "RTP"	6918462	"Retapamulin"	"Other antibacterials"	"D06AX13"	"Antibiotics for topical use"	"Other antibiotics for topical use"	"ret"	"altabax,altargo,retapamulin"					""
 "RZF"		"Rezafungin"	"Antifungals"	"NA"			""	"biafungin,rezafungin cation,rezafungin ion"					""
 "RBC"	44631912	"Ribociclib"	"Antifungals/antimycotics"	"L01EF02"	"Antimycotics for systemic use"	"Triazole derivatives"	"ribo"	"kisqali,ribociclib"	0.45				""
 "RST"	33042	"Ribostamycin"	"Aminoglycosides"	"J01GB10"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	""	"dekamycin iv,hetangmycin,ribastamin,ribostamicina,ribostamycin,ribostamycine,ribostamycinum,vistamycin,xylostatin"			1	"g"	""
 "RID1"	16659285	"Ridinilazole"	"Other antibacterials"	"NA"			""	"ridinilazole"					""
-"RIB"	135398743	"Rifabutin"	"Antimycobacterials"	"J04AB04"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"rifb"	"alfacid,ansamicin,ansamycin,ansatipin,ansatipine,assatipin,mycobutin,rifabutin,rifabutina,rifabutine,rifabutinum"	0.15	"g"			"24032-5"
+"RIB"	135398743	"Rifabutin"	"Antimycobacterials"	"J04AB04"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"rifb"	"alfacid,ansamicin,ansamycin,ansatipin,ansatipine,assatipin,mycobutin,rifabutin,rifabutina,rifabutine,rifabutinum"	0.15	"g"			"100699-8,16100-0,16386-5,16387-3,19149-4,20386-9,23630-7,24032-5,25199-1,25200-7,25201-5,42655-1,42656-9,54183-9,96113-6"
 "RIF"	135398735	"Rifampicin"	"Antimycobacterials"	"J04AB02"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"rifa"	"abrifam,archidyn,arficin,arzide,azt + rifampin,benemicin,benemycin,dipicin,doloresum,eremfat,famcin,fenampicin,rifadin,rifadin i.v,rifadin i.v.,rifadine,rifagen,rifaldazin,rifaldazine,rifaldin,rifamate,rifamicin amp,rifamor,rifampicin,rifampicin sv,rifampicina,rifampicine,rifampicinum,rifampin,rifamsolin,rifamycin amp,rifapiam,rifaprodin,rifcin,rifinah,rifobac,rifoldin,rifoldine,riforal,rimactan,rimactane,rimactazid,rimactizid,rimazid,rimycin,sinerdol,tubocin"	0.6	"g"	0.6	"g"	""
 "REI"	135483893	"Rifampicin/ethambutol/isoniazid"	"Antimycobacterials"	"J04AM07"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
 "RFI"		"Rifampicin/isoniazid"	"Antimycobacterials"	"J04AM02"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	"rifinah,rimactazid"					""
 "RPEI"		"Rifampicin/pyrazinamide/ethambutol/isoniazid"	"Antimycobacterials"	"J04AM06"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
 "RPI"		"Rifampicin/pyrazinamide/isoniazid"	"Antimycobacterials"	"J04AM05"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
 "RFM"	6324616	"Rifamycin"	"Antimycobacterials"	"A07AA13,D06AX15,J04AB03,S01AA16,S02AA12"	"Drugs for treatment of tuberculosis"	"Antibiotics"	""	"aemcolo,rifacin,rifamicina,rifamicine sv,rifamycin,rifamycine,rifamycinum,rifocin,rifocyn,rifomycin,rifomycin sv,tuborin"			0.6	"g"	""
-"RFP"	135403821	"Rifapentine"	"Antimycobacterials"	"J04AB05"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"rifp,rpt"	"cyclopentyl rifampin,prifitin,priftin,rifapentin,rifapentina,rifapentine,rifapentinum"	0.11	"g"			""
-"RFX"	6436173	"Rifaximin"	"Other antibacterials"	"A07AA11,D06AX11"	"Intestinal antiinfectives"	"Antibiotics"	""	"fatroximin,flonorm,lormyx,lumenax,normix,redactiv,rifacol,rifamixin,rifaxidin,rifaximin,rifaximina,rifaximine,rifaximinum,rifaxin,ritacol,spiraxin,xifaxan,xifaxsan"	0.6	"g"			""
+"RFP"	135403821	"Rifapentine"	"Antimycobacterials"	"J04AB05"	"Drugs for treatment of tuberculosis"	"Antibiotics"	"rifp,rpt"	"cyclopentyl rifampin,prifitin,priftin,rifapentin,rifapentina,rifapentine,rifapentinum"	0.11	"g"			"100059-5,76627-9"
+"RFX"	6436173	"Rifaximin"	"Other antibacterials"	"A07AA11,D06AX11"	"Intestinal antiinfectives"	"Antibiotics"	""	"fatroximin,flonorm,lormyx,lumenax,normix,redactiv,rifacol,rifamixin,rifaxidin,rifaximin,rifaximina,rifaximine,rifaximinum,rifaxin,ritacol,spiraxin,xifaxan,xifaxsan"	0.6	"g"			"73589-4,73611-6,73634-8"
 "RIT"	65633	"Ritipenem"	"Carbapenems"	"NA"			""	"ritipenem"					""
 "RIA"	163692	"Ritipenem acoxil"	"Carbapenems"	"NA"			""	"ritipenem acoxil"					""
 "ROK"	5282211	"Rokitamycin"	"Macrolides/lincosamides"	"J01FA12"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"propionylleucomycin,ricamycin,rokicid,rokital,rokitamicina,rokitamycin,rokitamycine,rokitamycinum"	0.8	"g"			""
-"RLT"	54682938	"Rolitetracycline"	"Tetracyclines"	"J01AA09"	"Tetracyclines"	"Tetracyclines"	""	"bristacin,kinteto,reverin,rolitetraciclina,rolitetracycline,rolitetracyclinum,solvocillin,superciclin,synotodecin,synterin,syntetrex,syntetrin,transcycline,velacicline,velacycline"			0.35	"g"	""
-"ROS"	287180	"Rosoxacin"	"Quinolones"	"J01MB01"	"Quinolone antibacterials"	"Other quinolones"	""	"acrosoxacin,eracine,eradacil,eradacin,eradicin,rosoxacin,rosoxacine,rosoxacino,rosoxacinum,roxadyl,winoxacin,winuron"	0.3	"g"			""
-"RXT"		"Roxithromycin"	"Macrolides/lincosamides"	"J01FA06"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"roxi"	"roxithromycin,roxithromycine,roxithromycinum,roxitromicina,rulide"	0.3	"g"			""
+"RLT"	54682938	"Rolitetracycline"	"Tetracyclines"	"J01AA09"	"Tetracyclines"	"Tetracyclines"	""	"bristacin,kinteto,reverin,rolitetraciclina,rolitetracycline,rolitetracyclinum,solvocillin,superciclin,synotodecin,synterin,syntetrex,syntetrin,transcycline,velacicline,velacycline"			0.35	"g"	"18976-1,435-8,436-6,437-4,438-2"
+"ROS"	287180	"Rosoxacin"	"Quinolones"	"J01MB01"	"Quinolone antibacterials"	"Other quinolones"	""	"acrosoxacin,eracine,eradacil,eradacin,eradicin,rosoxacin,rosoxacine,rosoxacino,rosoxacinum,roxadyl,winoxacin,winuron"	0.3	"g"			"18977-9,439-0,440-8,441-6,442-4,55713-2"
+"RXT"		"Roxithromycin"	"Macrolides/lincosamides"	"J01FA06"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"roxi"	"roxithromycin,roxithromycine,roxithromycinum,roxitromicina,rulide"	0.3	"g"			"18978-7,443-2,444-0,445-7,446-5,7046-6"
 "RFL"	58258	"Rufloxacin"	"Quinolones"	"J01MA10"	"Quinolone antibacterials"	"Fluoroquinolones"	""	"rufloxacin,rufloxacin hcl,rufloxacine,rufloxacino,rufloxacinum"	0.2	"g"			""
-"SAL"	3085092	"Salinomycin"	"Other antibacterials"	"NA"			""	"coxistac,procoxacin,salinomicina,salinomycin,salinomycine,salinomycinum"					"87593-0"
-"SAR"	56208	"Sarafloxacin"	"Quinolones"	"NA"			""	"difloxacine,difloxacino,difloxacinum,quinolone der.,saraflox,sarafloxacin,sarafloxacine,sarafloxacino,sarafloxacinum"					""
+"SAL"	3085092	"Salinomycin"	"Other antibacterials"	"NA"			""	"coxistac,procoxacin,salinomicina,salinomycin,salinomycine,salinomycinum"					"35836-6,35837-4,35838-2,87593-0"
+"SAR"	56208	"Sarafloxacin"	"Quinolones"	"NA"			""	"difloxacine,difloxacino,difloxacinum,quinolone der.,saraflox,sarafloxacin,sarafloxacine,sarafloxacino,sarafloxacinum"					"73588-6,73610-8,73633-0"
 "SRC"	54681908	"Sarecycline"	"Tetracyclines"	"J01AA14"	"Tetracyclines"	"Tetracyclines"	""	"sarecycline,seysara"	0.1	"g"			""
 "SRX"	9933415	"Sarmoxicillin"	"Beta-lactams/penicillins"	"NA"			""	"sarmoxicillin"					""
 "SEC"	71815	"Secnidazole"	"Other antibacterials"	"P01AB07"			""	"flagentyl,secnidal,secnidazol,secnidazole,secnidazolum,secnil,sindose,solosec"	2	"g"			""
 "SMF"		"Simvastatin/fenofibrate"	"Antimycobacterials"	"C10BA04"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	"simv"	""					""
-"SIS"	36119	"Sisomicin"	"Aminoglycosides"	"J01GB08"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"siso"	"rickamicin,salvamina,siseptin sulfate,sisomicin,sisomicin sulfate,sisomicina,sisomicine,sisomicinum,sisomin,sisomycin,sissomicin,sizomycin"			0.24	"g"	""
+"SIS"	36119	"Sisomicin"	"Aminoglycosides"	"J01GB08"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"siso"	"rickamicin,salvamina,siseptin sulfate,sisomicin,sisomicin sulfate,sisomicina,sisomicine,sisomicinum,sisomin,sisomycin,sissomicin,sizomycin"			0.24	"g"	"18979-5,447-3,448-1,449-9,450-7,55714-0"
 "SIT"	461399	"Sitafloxacin"	"Quinolones"	"J01MA21"			""	"gracevit,sitafloxacin,sitafloxacinisomer"	0.1	"g"			""
 "SDA"	2724368	"Sodium aminosalicylate"	"Antimycobacterials"	"J04AA02"	"Drugs for treatment of tuberculosis"	"Aminosalicylic acid and derivatives"	""	"bactylan,decapasil,lepasen,monopas,nippas,p.a.s. sodium,pamisyl sodium,parasal sodium,pas sodium,pasade,pasnal,passodico,salvis,sanipirol,sodiopas,sodium p.a.s,sodium pas,teebacin,tubersan"	14	"g"	14	"g"	""
-"SOL"	25242512	"Solithromycin"	"Macrolides/lincosamides"	"J01FA16"			""	"solithera,solithromycin"					""
-"SPX"	60464	"Sparfloxacin"	"Quinolones"	"J01MA09"	"Quinolone antibacterials"	"Fluoroquinolones"	"spa,spar"	"esparfloxacino,sparfloxacin,sparfloxacine,sparfloxacinum"	0.2	"g"			""
-"SPT"	15541	"Spectinomycin"	"Other antibacterials"	"J01XX04"	"Other antibacterials"	"Other antibacterials"	"sc,spe,spec,spt"	"actinospectacina,adspec,espectinomicina,prospec,specitinomycin,spectam,spectinomicina,spectinomycin,spectinomycin di hcl,spectinomycine,spectinomycinum,stanilo,togamycin,trobicin"			3	"g"	""
-"SPI"	6419898	"Spiramycin"	"Macrolides/lincosamides"	"J01FA02"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"spir"	"espiramicin,provamycin,rovamycin,rovamycine,sequamycin,spiramycine,spiramycinum"	3	"g"			""
+"SOL"	25242512	"Solithromycin"	"Macrolides/lincosamides"	"J01FA16"			""	"solithera,solithromycin"					"73587-8,73609-0,73632-2"
+"SPX"	60464	"Sparfloxacin"	"Quinolones"	"J01MA09"	"Quinolone antibacterials"	"Fluoroquinolones"	"spa,spar"	"esparfloxacino,sparfloxacin,sparfloxacine,sparfloxacinum"	0.2	"g"			"20397-6,23610-9,23628-1,35839-0,7047-4"
+"SPT"	15541	"Spectinomycin"	"Other antibacterials"	"J01XX04"	"Other antibacterials"	"Other antibacterials"	"sc,spe,spec,spt"	"actinospectacina,adspec,espectinomicina,prospec,specitinomycin,spectam,spectinomicina,spectinomycin,spectinomycin di hcl,spectinomycine,spectinomycinum,stanilo,togamycin,trobicin"			3	"g"	"18980-3,35840-8,451-5,452-3,453-1,454-9"
+"SPI"	6419898	"Spiramycin"	"Macrolides/lincosamides"	"J01FA02"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"spir"	"espiramicin,provamycin,rovamycin,rovamycine,sequamycin,spiramycine,spiramycinum"	3	"g"			"18981-1,455-6,456-4,457-2,458-0,55715-7"
 "SPM"		"Spiramycin/metronidazole"	"Other antibacterials"	"J01RA04"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "STR"		"Streptoduocin"	"Aminoglycosides"	"J01GA02"	"Aminoglycoside antibacterials"	"Streptomycins"	""	"ambistrin"			1	"g"	""
-"STR1"	19649	"Streptomycin"	"Aminoglycosides"	"A07AA04,J01GA01"	"Aminoglycoside antibacterials"	"Streptomycins"	"s,stm,str,stre"	"agrept,agrimycin,chemform,estreptomicina,neodiestreptopab,strepcen,streptomicina,streptomycin,streptomycin a,streptomycin spx,streptomycin sulfate,streptomycine,streptomycinum,streptomyzin,vetstrep"			1	"g"	"4039-4"
-"STH"		"Streptomycin-high"	"Aminoglycosides"	"NA"			"sthi,sthl,strepto high,streptomycin high"	""					""
+"STR1"	19649	"Streptomycin"	"Aminoglycosides"	"A07AA04,J01GA01"	"Aminoglycoside antibacterials"	"Streptomycins"	"s,stm,str,stre"	"agrept,agrimycin,chemform,estreptomicina,neodiestreptopab,strepcen,streptomicina,streptomycin,streptomycin a,streptomycin spx,streptomycin sulfate,streptomycine,streptomycinum,streptomyzin,vetstrep"			1	"g"	"18982-9,18983-7,20462-8,23626-5,25185-0,25205-6,25206-4,35841-6,4039-4,42658-5,42659-3,459-8,460-6,461-4,462-2,46719-1,48177-0,6933-6,7048-2,7049-0,96114-4"
+"STH"		"Streptomycin-high"	"Aminoglycosides"	"NA"			"sthi,sthl,strepto high,streptomycin high"	""					"18983-7,35841-6,6933-6,7049-0"
 "STI"		"Streptomycin/isoniazid"	"Antimycobacterials"	"J04AM01"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
-"SUL"	130313	"Sulbactam"	"Beta-lactams/penicillins"	"J01CG01"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase inhibitors"	""	"betamaze,sulbactam,sulbactam acid,sulbactam free acid,sulbactamum"			1	"g"	""
+"SUL"	130313	"Sulbactam"	"Beta-lactams/penicillins"	"J01CG01"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase inhibitors"	""	"betamaze,sulbactam,sulbactam acid,sulbactam free acid,sulbactamum"			1	"g"	"41716-2,41717-0,41718-8,41739-4"
 "SBC"	20055036	"Sulbenicillin"	"Beta-lactams/penicillins"	"J01CA16"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"kedacillina,sulbenicilina,sulbenicillin,sulbenicilline,sulbenicillinum"			15	"g"	""
 "SUC"	5318	"Sulconazole"	"Antifungals/antimycotics"	"D01AC09"			""	"sulconazol,sulconazole,sulconazolum"					""
 "SUP"	6634	"Sulfachlorpyridazine"	"Other antibacterials"	"NA"			""	"cluricol,cosulid,cosumix,durasulf,nefrosul,nsulfanilamide,prinzone vet,prinzone vet.,solfaclorpiridazina,sonilyn,sulfachlorpyridazine,sulfacloropiridazina,vetisulid"					""
-"SDI"	5215	"Sulfadiazine"	"Trimethoprims"	"J01EC02"	"Sulfonamides and trimethoprim"	"Intermediate-acting sulfonamides"	""	"adiazin,adiazine,cocodiazine,codiazine,cremodiazine,cremotres,debenal,deltazina,diazin,diazolone,diazovit,diazyl,eskadiazine,honey diazine,liquadiazine,microsulfon,neazine,neotrizine,nsulfanilamide,palatrize,piridisir,pirimal,pyrimal,quadetts,quadramoid,sanodiazine,sildaflo,silvadene,solfadiazina,spofadrizine,sterazine,sulfacombin,sulfadiazene,sulfadiazin,sulfadiazina,sulfadiazine,sulfadiazinum,sulfapirimidin,sulfapyrimidin,sulfapyrimidine,sulfatryl,sulfazine,sulfolex,sulfonamides duplex,sulfonsol,sulfose,sulphadiazine,sulphadiazine e,terfonyl,theradiazine,thermazene,trifonamide,triple sulfa,triple sulfas,trisem,truozine,zinc sulfadiazine"	0.6	"g"			"27216-1,59742-7,6907-0"
+"SDI"	5215	"Sulfadiazine"	"Trimethoprims"	"J01EC02"	"Sulfonamides and trimethoprim"	"Intermediate-acting sulfonamides"	""	"adiazin,adiazine,cocodiazine,codiazine,cremodiazine,cremotres,debenal,deltazina,diazin,diazolone,diazovit,diazyl,eskadiazine,honey diazine,liquadiazine,microsulfon,neazine,neotrizine,nsulfanilamide,palatrize,piridisir,pirimal,pyrimal,quadetts,quadramoid,sanodiazine,sildaflo,silvadene,solfadiazina,spofadrizine,sterazine,sulfacombin,sulfadiazene,sulfadiazin,sulfadiazina,sulfadiazine,sulfadiazinum,sulfapirimidin,sulfapyrimidin,sulfapyrimidine,sulfatryl,sulfazine,sulfolex,sulfonamides duplex,sulfonsol,sulfose,sulphadiazine,sulphadiazine e,terfonyl,theradiazine,thermazene,trifonamide,triple sulfa,triple sulfas,trisem,truozine,zinc sulfadiazine"	0.6	"g"			"18984-5,27216-1,463-0,464-8,465-5,466-3,59742-7,6907-0,7050-8"
 "SLT"	122284	"Sulfadiazine/tetroxoprim"	"Trimethoprims"	"J01EE06"	"Sulfonamides and trimethoprim"	"Combinations of sulfonamides and trimethoprim, incl. derivatives"	""	"cotetroxazine"					""
 "SLT1"	64932	"Sulfadiazine/trimethoprim"	"Trimethoprims"	"J01EE02"	"Sulfonamides and trimethoprim"	"Combinations of sulfonamides and trimethoprim, incl. derivatives"	""	"antastmon,cotrimazine,diaziprim forte,ditrim,ditrivet,sultrisan,triglobe,trimin,tucoprim,uniprim"					""
-"SUD"	5323	"Sulfadimethoxine"	"Trimethoprims"	"J01ED01"	"Sulfonamides and trimethoprim"	"Long-acting sulfonamides"	""	"agribon,arnosulfan,bactrovet,deposul,diasulfa,diasulfyl,dimetazina,dinosol,dorisul,lasibon,madribon,madrigid,madriqid,madroxin,madroxine,maxulvet,mecozine,memcozine,metoxidon,neostrepal,neostreptal,nsulfanilamide,omnibon,persulfen,primor,radonin,redifal,rofenaid,roscosulf,scandisil,solfadimetossina,sudine,suldixine,sulfabon,sulfadimethoxin,sulfadimethoxine,sulfadimethoxinum,sulfadimetossina,sulfadimetoxin,sulfadimetoxina,sulfadimetoxine,sulfadimoxine,sulfastop,sulfdimethoxine,sulfoplan,sulphadimethoxine,sulxin,sumbio,symbio,theracanzan,ultrasulfon"	0.5	"g"			""
+"SUD"	5323	"Sulfadimethoxine"	"Trimethoprims"	"J01ED01"	"Sulfonamides and trimethoprim"	"Long-acting sulfonamides"	""	"agribon,arnosulfan,bactrovet,deposul,diasulfa,diasulfyl,dimetazina,dinosol,dorisul,lasibon,madribon,madrigid,madriqid,madroxin,madroxine,maxulvet,mecozine,memcozine,metoxidon,neostrepal,neostreptal,nsulfanilamide,omnibon,persulfen,primor,radonin,redifal,rofenaid,roscosulf,scandisil,solfadimetossina,sudine,suldixine,sulfabon,sulfadimethoxin,sulfadimethoxine,sulfadimethoxinum,sulfadimetossina,sulfadimetoxin,sulfadimetoxina,sulfadimetoxine,sulfadimoxine,sulfastop,sulfdimethoxine,sulfoplan,sulphadimethoxine,sulxin,sumbio,symbio,theracanzan,ultrasulfon"	0.5	"g"			"87799-3,87803-3"
 "SDM"	5327	"Sulfadimidine"	"Trimethoprims"	"J01EB03"	"Sulfonamides and trimethoprim"	"Short-acting sulfonamides"	""	"azolmetazin,benzene sulfonamide,calfspan,calfspan tablets,cremomethazine,diazil,diazilsulfadine,dimezathine,intradine,kelametazine,mermeth,metazin,neasina,neazina,nsulfanilamide,panazin,pirmazin,primazin,sa iii,solfadimidina,spanbolet,sulfadimerazine,sulfadimesin,sulfadimesine,sulfadimethyldiazine,sulfadimezin,sulfadimezine,sulfadimezinum,sulfadimidin,sulfadimidina,sulfadimidine,sulfadimidinum,sulfadine,sulfametazina,sulfametazyny,sulfamethazine,sulfamethiazine,sulfamezathine,sulfamidine,sulfasure sr bolus,sulfodimesin,sulfodimezine,sulka k boluses,sulka s boluses,sulmet,sulphadimidine,sulphamethasine,sulphamethazine,sulphamezathine,sulphamidine,sulphodimezine,superseptil,superseptyl,vertolan"	4	"g"			""
 "SLT2"		"Sulfadimidine/trimethoprim"	"Trimethoprims"	"J01EE05"	"Sulfonamides and trimethoprim"	"Combinations of sulfonamides and trimethoprim, incl. derivatives"	""	""					""
 "SLF"	5344	"Sulfafurazole"	"Trimethoprims"	"J01EB05,S01AB02"	"Sulfonamides and trimethoprim"	"Short-acting sulfonamides"	"sfsz"	"accuzole,alphazole,amidoxal,astrazolo,azo gantrisin,azosulfizin,bactesulf,barazae,chemouag,cosoxazole,dorsulfan,dorsulfan warthausen,entusil,entusul,eryzole,gantrisin,gantrisine,gantrisona,gantrizin,gantrosan,isoxamin,neazolin,neoxazoi,neoxazol,novazolo,novosaxazole,nsulfanilamide,nsulphanilamide,pancid,pediazole,renosulfan,resoxol,roxosul,roxosul tablets,roxoxol,saxosozine,sodizole,solfafurazolo,soxamide,soxazole,soxisol,soxitabs,soxomide,stansin,sulbio,sulfafuraz ole,sulfafurazol,sulfafurazole,sulfafurazolum,sulfagan,sulfagen,sulfaisoxazole,sulfalar,sulfapolar,sulfasol,sulfasoxazole,sulfasoxizole,sulfazin,sulfisin,sulfisonazole,sulfisoxasole,sulfisoxazol,sulfisoxazole,sulfisoxazolum,sulfizin,sulfizol,sulfizole,sulfofurazole,sulfoxol,suloxsol,sulphafuraz,sulphafurazol,sulphafurazole,sulphafurazolum,sulphaisoxazole,sulphisoxazol,sulphisoxazole,sulphofurazole,sulsoxin,thiasin,unisulf,urisoxin,uritrisin,urogan,vagilia"	4	"g"	4	"g"	""
@@ -410,7 +410,7 @@
 "SLT3"		"Sulfamerazine/trimethoprim"	"Trimethoprims"	"J01EE07"	"Sulfonamides and trimethoprim"	"Combinations of sulfonamides and trimethoprim, incl. derivatives"	""	""					""
 "SUM"	5327	"Sulfamethazine"	"Other antibacterials"	"NA"			""	"azolmetazin,benzene sulfonamide,calfspan,calfspan tablets,cremomethazine,diazil,diazilsulfadine,dimezathine,intradine,kelametazine,mermeth,metazin,neasina,neazina,nsulfanilamide,panazin,pirmazin,primazin,sa iii,solfadimidina,spanbolet,sulfadimerazine,sulfadimesin,sulfadimesine,sulfadimethyldiazine,sulfadimezin,sulfadimezine,sulfadimezinum,sulfadimidin,sulfadimidina,sulfadimidine,sulfadimidinum,sulfadine,sulfametazina,sulfametazyny,sulfamethazine,sulfamethiazine,sulfamezathine,sulfamidine,sulfasure sr bolus,sulfodimesin,sulfodimezine,sulka k boluses,sulka s boluses,sulmet,sulphadimidine,sulphamethasine,sulphamethazine,sulphamezathine,sulphamidine,sulphodimezine,superseptil,superseptyl,vertolan"					"87592-2"
 "SLF4"	5328	"Sulfamethizole"	"Trimethoprims"	"B05CA04,D06BA04,J01EB02,S01AB01"	"Sulfonamides and trimethoprim"	"Short-acting sulfonamides"	"sfmz"	"ayerlucil,lucosil,methazol,microsul,nsulfanilamide,proklar,renasul,salimol,solfametizolo,sulamethizole,sulfa gram,sulfamethizol,sulfamethizole,sulfamethizolum,sulfametizol,sulfapyelon,sulfstat,sulfurine,sulphamethizole,tetracid,thidicur,thiosulfil,thiosulfil forte,ultrasul,urocydal,urodiaton,urolucosil,urosulfin"	4	"g"			"60175-7,60176-5,60177-3"
-"SMX"	5329	"Sulfamethoxazole"	"Trimethoprims"	"J01EC01"	"Sulfonamides and trimethoprim"	"Intermediate-acting sulfonamides"	"sfmx,sulf"	"azo gantanol,gamazole,gantanol,gantanol ds,metoxal,nsulfanilamide,nsulphanilamide,radonil,septran,simsinomin,sinomin,solfametossazolo,sulfamethalazole,sulfamethoxazol,sulfamethoxazole,sulfamethoxazolum,sulfamethoxizole,sulfamethylisoxazole,sulfametoxazol,sulfisomezole,sulmeprim,sulphamethalazole,sulphamethoxazol,sulphamethoxazole,sulphisomezole,urobak"	2	"g"			"10342-4,25271-8,39772-9,59971-2,59972-0,60333-2,72674-5,80549-9,80974-9"
+"SMX"	5329	"Sulfamethoxazole"	"Trimethoprims"	"J01EC01"	"Sulfonamides and trimethoprim"	"Intermediate-acting sulfonamides"	"sfmx,sulf"	"azo gantanol,gamazole,gantanol,gantanol ds,metoxal,nsulfanilamide,nsulphanilamide,radonil,septran,simsinomin,sinomin,solfametossazolo,sulfamethalazole,sulfamethoxazol,sulfamethoxazole,sulfamethoxazolum,sulfamethoxizole,sulfamethylisoxazole,sulfametoxazol,sulfisomezole,sulmeprim,sulphamethalazole,sulphamethoxazol,sulphamethoxazole,sulphisomezole,urobak"	2	"g"			"10342-4,11577-4,18985-2,25271-8,39772-9,467-1,468-9,469-7,470-5,59971-2,59972-0,60333-2,72674-5,80549-9,80974-9"
 "SLF5"	5330	"Sulfamethoxypyridazine"	"Trimethoprims"	"J01ED05"	"Sulfonamides and trimethoprim"	"Long-acting sulfonamides"	""	"altezol,davosin,depovernil,kineks,lederkyn,lentac,lisulfen,longin,medicel,midicel,midikel,myasul,nsulfanilamide,opinsul,paramid,paramid supra,petrisul,piridolo,quinoseptyl,retamid,retasulfin,retasulphine,slosul,spofadazine,sulfalex,sulfapyridazine,sulfdurazin,sulfozona,sultirene,vinces"	0.5	"g"			""
 "SLF6"	19596	"Sulfametomidine"	"Trimethoprims"	"J01ED03"	"Sulfonamides and trimethoprim"	"Long-acting sulfonamides"	""	"duroprocin,methofadin,methofazine,nsulfanilamide,solfametomidina,sulfamethomidine,sulfametomidin,sulfametomidina,sulfametomidine,sulfametomidinum"					""
 "SLF7"	5326	"Sulfametoxydiazine"	"Trimethoprims"	"J01ED04"	"Sulfonamides and trimethoprim"	"Long-acting sulfonamides"	""	"bayrena,berlicid,dairena,durenat,juvoxin,kinecid,kirocid,longasulf,methoxypyrimal,nsulfanilamide,solfametossidiazina,sulfameter,sulfamethorine,sulfamethoxine,sulfamethoxydiazin,sulfamethoxydiazine,sulfamethoxydin,sulfamethoxydine,sulfametin,sulfametinum,sulfametorin,sulfametorine,sulfametorinum,sulfametoxidiazina,sulfametoxidine,sulfametoxydiazine,sulfametoxydiazinum,sulphameter,sulphamethoxydiazine,supramid,ultrax"	0.5	"g"			""
@@ -422,63 +422,63 @@
 "SLF11"	5335	"Sulfaphenazole"	"Trimethoprims"	"J01ED08"	"Sulfonamides and trimethoprim"	"Long-acting sulfonamides"	""	"depocid,depotsulfonamide,eftolon,firmazolo,inamil,isarol,isarol v,merian,microtan pirazolo,nsulfanilamide,orisul,orisulf,paidazolo,phenylsulfapyrazole,plisulfan,raziosulfa,solfafenazolo,sulfabid,sulfafenazol,sulfafenazolo,sulfaphenazol,sulfaphenazole,sulfaphenazolum,sulfaphenazon,sulfaphenylpipazol,sulfaphenylpyrazol,sulfaphenylpyrazole,sulfonylpyrazol,sulphaphenazole,sulphenazole"	1	"g"			""
 "SLF12"	5336	"Sulfapyridine"	"Trimethoprims"	"J01EB04"	"Sulfonamides and trimethoprim"	"Short-acting sulfonamides"	""	"adiplon,coccoclase,dagenan,eubasin,eubasinum,haptocil,piridazol,plurazol,pyriamid,pyridazol,relbapiridina,septipulmon,solfapiridina,streptosilpyridine,sulfapiridina,sulfapyridin,sulfapyridine,sulfapyridinum,sulfidin,sulfidine,sulphapyridin,sulphapyridine,thioseptal,trianon"	1	"g"			"14075-6,55580-5"
 "SNA"	60582	"Sulfasuccinamide"	"Other antibacterials"	"NA"			""	"ambesid,derganil,sulfasuccinamid,sulfasuccinamida,sulfasuccinamide,sulfasuccinamidum"					""
-"SUT"	5340	"Sulfathiazole"	"Trimethoprims"	"D06BA02,J01EB07"	"Sulfonamides and trimethoprim"	"Short-acting sulfonamides"	""	"azoquimiol,azoseptale,cerazol,cerazole,chemosept,cibazol,duatok,dulana,eleudron,enterobiocine,estafilol,formosulfathiazole,neostrepsan,norsulfasol,norsulfazol,norsulfazole,norsulfazolum,nsulfanilamide,planomide,poliseptil,sanotiazol,septozol,sodium sulfathiazole,solfatiazolo,streptosilthiazole,sulfamul,sulfathiazol,sulfathiazole,sulfathiazolum,sulfatiazol,sulfavitina,sulfocerol,sulphathiazole,sulzol,thiacoccine,thiasulfol,thiazamide,thiozamide,triple sulfa,wintrazole"					"87591-4"
+"SUT"	5340	"Sulfathiazole"	"Trimethoprims"	"D06BA02,J01EB07"	"Sulfonamides and trimethoprim"	"Short-acting sulfonamides"	""	"azoquimiol,azoseptale,cerazol,cerazole,chemosept,cibazol,duatok,dulana,eleudron,enterobiocine,estafilol,formosulfathiazole,neostrepsan,norsulfasol,norsulfazol,norsulfazole,norsulfazolum,nsulfanilamide,planomide,poliseptil,sanotiazol,septozol,sodium sulfathiazole,solfatiazolo,streptosilthiazole,sulfamul,sulfathiazol,sulfathiazole,sulfathiazolum,sulfatiazol,sulfavitina,sulfocerol,sulphathiazole,sulzol,thiacoccine,thiasulfol,thiazamide,thiozamide,triple sulfa,wintrazole"					"87591-4,87796-9,87797-7"
 "SLF13"	3000579	"Sulfathiourea"	"Trimethoprims"	"J01EB08"	"Sulfonamides and trimethoprim"	"Short-acting sulfonamides"	""	"badional,baldinol,fontamide,salvoseptyl,solfatiourea,solufontamide,sulfanilthiourea,sulfathiocarbamid,sulfathiocarbamide,sulfathiocarbamidum,sulfathiourea,sulfathiouree,sulfatiourea,sulphathiourea"	6	"g"			""
-"SOX"	5344	"Sulfisoxazole"	"Other antibacterials"	"NA"			""	"accuzole,alphazole,amidoxal,astrazolo,azo gantrisin,azosulfizin,bactesulf,barazae,chemouag,cosoxazole,dorsulfan,dorsulfan warthausen,entusil,entusul,eryzole,gantrisin,gantrisine,gantrisona,gantrizin,gantrosan,isoxamin,neazolin,neoxazoi,neoxazol,novazolo,novosaxazole,nsulfanilamide,nsulphanilamide,pancid,pediazole,renosulfan,resoxol,roxosul,roxosul tablets,roxoxol,saxosozine,sodizole,solfafurazolo,soxamide,soxazole,soxisol,soxitabs,soxomide,stansin,sulbio,sulfafuraz ole,sulfafurazol,sulfafurazole,sulfafurazolum,sulfagan,sulfagen,sulfaisoxazole,sulfalar,sulfapolar,sulfasol,sulfasoxazole,sulfasoxizole,sulfazin,sulfisin,sulfisonazole,sulfisoxasole,sulfisoxazol,sulfisoxazole,sulfisoxazolum,sulfizin,sulfizol,sulfizole,sulfofurazole,sulfoxol,suloxsol,sulphafuraz,sulphafurazol,sulphafurazole,sulphafurazolum,sulphaisoxazole,sulphisoxazol,sulphisoxazole,sulphofurazole,sulsoxin,thiasin,unisulf,urisoxin,uritrisin,urogan,vagilia"					"9701-4"
-"SSS"	86225	"Sulfonamide"	"Other antibacterials"	"NA"			"sfna"	"anhydron,aquirel,ciclotiazida,ciclotiazide,cyclothiazide,cyclothiazidum,doburil,fluidil,renazide,valmiran"					""
-"SLP"	9950244	"Sulopenem"	"Other antibacterials"	"NA"			""	"sulopenem"					""
+"SOX"	5344	"Sulfisoxazole"	"Other antibacterials"	"NA"			""	"accuzole,alphazole,amidoxal,astrazolo,azo gantrisin,azosulfizin,bactesulf,barazae,chemouag,cosoxazole,dorsulfan,dorsulfan warthausen,entusil,entusul,eryzole,gantrisin,gantrisine,gantrisona,gantrizin,gantrosan,isoxamin,neazolin,neoxazoi,neoxazol,novazolo,novosaxazole,nsulfanilamide,nsulphanilamide,pancid,pediazole,renosulfan,resoxol,roxosul,roxosul tablets,roxoxol,saxosozine,sodizole,solfafurazolo,soxamide,soxazole,soxisol,soxitabs,soxomide,stansin,sulbio,sulfafuraz ole,sulfafurazol,sulfafurazole,sulfafurazolum,sulfagan,sulfagen,sulfaisoxazole,sulfalar,sulfapolar,sulfasol,sulfasoxazole,sulfasoxizole,sulfazin,sulfisin,sulfisonazole,sulfisoxasole,sulfisoxazol,sulfisoxazole,sulfisoxazolum,sulfizin,sulfizol,sulfizole,sulfofurazole,sulfoxol,suloxsol,sulphafuraz,sulphafurazol,sulphafurazole,sulphafurazolum,sulphaisoxazole,sulphisoxazol,sulphisoxazole,sulphofurazole,sulsoxin,thiasin,unisulf,urisoxin,uritrisin,urogan,vagilia"					"11578-2,18986-0,25226-2,471-3,472-1,473-9,474-7,9701-4"
+"SSS"	86225	"Sulfonamide"	"Other antibacterials"	"NA"			"sfna"	"anhydron,aquirel,ciclotiazida,ciclotiazide,cyclothiazide,cyclothiazidum,doburil,fluidil,renazide,valmiran"					"17674-3,17675-0,18987-8,35842-4,4040-2,4041-0,4042-8,475-4,476-2,477-0,478-8,75650-2"
+"SLP"	9950244	"Sulopenem"	"Other antibacterials"	"NA"			""	"sulopenem"					"55289-3,55290-1,55291-9"
 "SLT6"	444022	"Sultamicillin"	"Beta-lactams/penicillins"	"J01CR04"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	""	"sultamicilina,sultamicillin,sultamicillinum"	1.5	"g"			""
 "SUR"	46700778	"Surotomycin"	"Other antibacterials"	"NA"			""	"surotomycin"					""
-"TAL"	71447	"Talampicillin"	"Beta-lactams/penicillins"	"J01CA15"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"talampicilina,talampicillin,talampicilline,talampicillinum"	2	"g"			""
+"TAL"	71447	"Talampicillin"	"Beta-lactams/penicillins"	"J01CA15"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	""	"talampicilina,talampicillin,talampicilline,talampicillinum"	2	"g"			"18988-6,479-6,480-4,481-2,482-0"
 "TLP"	163307	"Talmetoprim"	"Other antibacterials"	"NA"			""	"talmetoprim"					""
-"TAZ"	123630	"Tazobactam"	"Beta-lactams/penicillins"	"J01CG02"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase inhibitors"	"tazo"	"tazobactam,tazobactam acid,tazobactamum,tazobactum"					""
+"TAZ"	123630	"Tazobactam"	"Beta-lactams/penicillins"	"J01CG02"	"Beta-lactam antibacterials, penicillins"	"Beta-lactamase inhibitors"	"tazo"	"tazobactam,tazobactam acid,tazobactamum,tazobactum"					"41719-6,41720-4,41721-2,41740-2"
 "TBP"	9800194	"Tebipenem"	"Carbapenems"	"NA,J01DH06"			""	"tebipenem pivoxil"					""
-"TZD"	11234049	"Tedizolid"	"Oxazolidinones"	"J01XX11"	"Other antibacterials"	"Other antibacterials"	"tedi"	"sivextro,tedizolid,torezolid"	0.2	"g"	0.2	"g"	""
-"TEC"	16131923	"Teicoplanin"	"Glycopeptides"	"J01XA02"	"Other antibacterials"	"Glycopeptide antibacterials"	"tec,tei,teic,tp,tpl,tpn"	"targocid,tecoplanina,tecoplanine,tecoplaninum,teichomycin,teicoplanin,teicoplanina,teicoplanine,teicoplaninum"			0.4	"g"	"25534-9,25535-6,34378-0,34379-8,4043-6,80968-1"
+"TZD"	11234049	"Tedizolid"	"Oxazolidinones"	"J01XX11"	"Other antibacterials"	"Other antibacterials"	"tedi"	"sivextro,tedizolid,torezolid"	0.2	"g"	0.2	"g"	"73586-0,73608-2,73631-4"
+"TEC"	16131923	"Teicoplanin"	"Glycopeptides"	"J01XA02"	"Other antibacterials"	"Glycopeptide antibacterials"	"tec,tei,teic,tp,tpl,tpn"	"targocid,tecoplanina,tecoplanine,tecoplaninum,teichomycin,teicoplanin,teicoplanina,teicoplanine,teicoplaninum"			0.4	"g"	"18989-4,25534-9,25535-6,34378-0,34379-8,4043-6,483-8,484-6,485-3,486-1,7051-6,80968-1"
 "TCM"		"Teicoplanin-macromethod"	"Glycopeptides"	"NA"			""	""					""
-"TLV"	3081362	"Telavancin"	"Glycopeptides"	"J01XA03"	"Other antibacterials"	"Glycopeptide antibacterials"	"tela"	"telavancin,televancin,vibativ"					""
-"TLT"	3002190	"Telithromycin"	"Macrolides/lincosamides"	"J01FA15"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"teli"	"levviax,telithromycin"	0.8	"g"			""
-"TMX"	60021	"Temafloxacin"	"Quinolones"	"J01MA05"	"Quinolone antibacterials"	"Fluoroquinolones"	"tema"	"omniflox,temafloxacin,temafloxacina,temafloxacine,temafloxacinum"	0.8	"g"			""
-"TEM"	171758	"Temocillin"	"Beta-lactams/penicillins"	"J01CA17"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"temo"	"negaban,temocilina,temocillin,temocillina,temocilline,temocillinum"			4	"g"	""
-"TRB"	1549008	"Terbinafine"	"Antifungals/antimycotics"	"D01AE15,D01BA02"	"Antifungals for systemic use"	"Antifungals for systemic use"	"terb"	"corbinal,lamasil,lamisil,lamisil at,lamisil tablet,terbinafina,terbinafine,terbinafinum,terbinex"	0.25	"g"			""
-"TRC"	441383	"Terconazole"	"Antifungals/antimycotics"	"G01AG02"			""	"fungistat,panlomyc,terazol,terconazol,terconazole,terconazolum,tercospor,triaconazole,zazole"					""
+"TLV"	3081362	"Telavancin"	"Glycopeptides"	"J01XA03"	"Other antibacterials"	"Glycopeptide antibacterials"	"tela"	"telavancin,televancin,vibativ"					"72894-9,73630-6,85051-1,88886-7"
+"TLT"	3002190	"Telithromycin"	"Macrolides/lincosamides"	"J01FA15"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	"teli"	"levviax,telithromycin"	0.8	"g"			"35843-2,35844-0,35845-7,41722-0"
+"TMX"	60021	"Temafloxacin"	"Quinolones"	"J01MA05"	"Quinolone antibacterials"	"Fluoroquinolones"	"tema"	"omniflox,temafloxacin,temafloxacina,temafloxacine,temafloxacinum"	0.8	"g"			"18990-2,487-9,488-7,489-5,490-3"
+"TEM"	171758	"Temocillin"	"Beta-lactams/penicillins"	"J01CA17"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"temo"	"negaban,temocilina,temocillin,temocillina,temocilline,temocillinum"			4	"g"	"18991-0,491-1,492-9,493-7,494-5,54190-4"
+"TRB"	1549008	"Terbinafine"	"Antifungals/antimycotics"	"D01AE15,D01BA02"	"Antifungals for systemic use"	"Antifungals for systemic use"	"terb"	"corbinal,lamasil,lamisil,lamisil at,lamisil tablet,terbinafina,terbinafine,terbinafinum,terbinex"	0.25	"g"			"10720-1,10721-9,18992-8"
+"TRC"	441383	"Terconazole"	"Antifungals/antimycotics"	"G01AG02"			""	"fungistat,panlomyc,terazol,terconazol,terconazole,terconazolum,tercospor,triaconazole,zazole"					"55196-0"
 "TRZ"	65720	"Terizidone"	"Antimycobacterials"	"J04AK03"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	""	"terivalidin,terizidon,terizidona,terizidone,terizidonum"					""
-"TCY"	54675776	"Tetracycline"	"Tetracyclines"	"A01AB13,D06AA04,J01AA07,S01AA09,S02AA08,S03AA02"	"Tetracyclines"	"Tetracyclines"	"tc,te,tet,tetr"	"abramycin,abricycline,achromycin,achromycin v,actisite,agromicina,ambramicina,ambramycin,amycin,biocycline,bristaciclin,bristaciclina,bristacycline,brodspec,cefracycline,centet,ciclibion,copharlan,criseociclina,cyclomycin,cyclopar,cytome,democracin,deschlorobiomycin,dumocyclin,economycin,enterocycline,hostacyclin,lexacycline,limecycline,liquamycin,medocycline,mericycline,micycline,neocycline,oletetrin,omegamycin,orlycycline,panmycin,piracaps,polycycline,polyotic,purocyclina,resteclin,robitet,roviciclina,sigmamycin,solvocin,sumycin,sumycin syrup,supramycin,sustamycin,tetrabid organon,tetrabon,tetrachel,tetraciclina,tetracycl,tetracyclin,tetracycline,tetracycline base,tetracycline i,tetracycline ii,tetracyclinehydrate,tetracyclinum,tetracyn,tetradecin,tetrafil,tetramed,tetrasure,tetraverine,tetrazyklin,tetrex,topicycline,tsiklomistsin,tsiklomitsin,veracin,vetacyclinum,vetquamycin"	1	"g"	1	"g"	"25272-6,4045-1,87590-6"
+"TCY"	54675776	"Tetracycline"	"Tetracyclines"	"A01AB13,D06AA04,J01AA07,S01AA09,S02AA08,S03AA02"	"Tetracyclines"	"Tetracyclines"	"tc,te,tet,tetr"	"abramycin,abricycline,achromycin,achromycin v,actisite,agromicina,ambramicina,ambramycin,amycin,biocycline,bristaciclin,bristaciclina,bristacycline,brodspec,cefracycline,centet,ciclibion,copharlan,criseociclina,cyclomycin,cyclopar,cytome,democracin,deschlorobiomycin,dumocyclin,economycin,enterocycline,hostacyclin,lexacycline,limecycline,liquamycin,medocycline,mericycline,micycline,neocycline,oletetrin,omegamycin,orlycycline,panmycin,piracaps,polycycline,polyotic,purocyclina,resteclin,robitet,roviciclina,sigmamycin,solvocin,sumycin,sumycin syrup,supramycin,sustamycin,tetrabid organon,tetrabon,tetrachel,tetraciclina,tetracycl,tetracyclin,tetracycline,tetracycline base,tetracycline i,tetracycline ii,tetracyclinehydrate,tetracyclinum,tetracyn,tetradecin,tetrafil,tetramed,tetrasure,tetraverine,tetrazyklin,tetrex,topicycline,tsiklomistsin,tsiklomitsin,veracin,vetacyclinum,vetquamycin"	1	"g"	1	"g"	"101504-9,18993-6,25272-6,4045-1,495-2,496-0,497-8,498-6,7052-4,87590-6"
 "TOL"	54691494	"Tetracycline/oleandomycin"	"Other antibacterials"	"J01RA08"	"Combinations of antibacterials"	"Combinations of antibacterials"	""	""					""
 "TET"	65450	"Tetroxoprim"	"Other antibacterials"	"NA"			""	"tetroxoprim,tetroxoprima,tetroxoprime,tetroxoprimum"					""
-"THA"	9568512	"Thiacetazone"	"Oxazolidinones"	"NA"			""	"aktivan,ambathizon,amithiozone,amithizone,amitiozon,benthiozone,benzothiozane,benzothiozon,berculon a,berkazon,citazone,conteben,diasan,diazan,domakol,ilbion,livazone,mirizone neustab,mivizon,myvizone,neotibil,neustab,novakol,nuclon argentinian,panrone,parazone,seroden,siocarbazone,tebalon,tebecure,tebemar,tebesone i,tebethion,tebethione,tebezon,thiacetazone,thiacetone,thiacetozone,thibon,thibone,thioacetazon,thioacetazone,thioacetazonum,thioazetazone,thiocarbazil,thiomicid,thionicid,thioparamizon,thioparamizone,thiosemicarbarzone,thiosemicarbazone,thiotebesin,thiotebezin,thiotebicina,thizone,tiacetazon,tibicur,tibion,tibione,tibizan,tibone,tioacetazon,tioacetazona,tioatsetazon,tiobicina,tiocarone,tiosecolo,tubercazon,tubigal"					""
-"THI"	27200	"Thiamphenicol"	"Amphenicols"	"J01BA02"	"Amphenicols"	"Amphenicols"	""	"descocin,dexawin,dextrosulfenidol,dextrosulphenidol,efnicol,hyrazin,igralin,macphenicol,masatirin,neomyson,racefenicol,racefenicolo,racefenicolum,raceophenidol,racephenicol,rincrol,thiamcol,thiamphenicol,thiamphenicolum,thiocymetin,thiomycetin,thiophenicol,tiamfenicol,tiamfenicolo,urfamicina,urfamycine,vicemycetin"	1.5	"g"	1.5	"g"	""
+"THA"	9568512	"Thiacetazone"	"Oxazolidinones"	"NA"			""	"aktivan,ambathizon,amithiozone,amithizone,amitiozon,benthiozone,benzothiozane,benzothiozon,berculon a,berkazon,citazone,conteben,diasan,diazan,domakol,ilbion,livazone,mirizone neustab,mivizon,myvizone,neotibil,neustab,novakol,nuclon argentinian,panrone,parazone,seroden,siocarbazone,tebalon,tebecure,tebemar,tebesone i,tebethion,tebethione,tebezon,thiacetazone,thiacetone,thiacetozone,thibon,thibone,thioacetazon,thioacetazone,thioacetazonum,thioazetazone,thiocarbazil,thiomicid,thionicid,thioparamizon,thioparamizone,thiosemicarbarzone,thiosemicarbazone,thiotebesin,thiotebezin,thiotebicina,thizone,tiacetazon,tibicur,tibion,tibione,tibizan,tibone,tioacetazon,tioacetazona,tioatsetazon,tiobicina,tiocarone,tiosecolo,tubercazon,tubigal"					"32384-0,54184-7,54204-3"
+"THI"	27200	"Thiamphenicol"	"Amphenicols"	"J01BA02"	"Amphenicols"	"Amphenicols"	""	"descocin,dexawin,dextrosulfenidol,dextrosulphenidol,efnicol,hyrazin,igralin,macphenicol,masatirin,neomyson,racefenicol,racefenicolo,racefenicolum,raceophenidol,racephenicol,rincrol,thiamcol,thiamphenicol,thiamphenicolum,thiocymetin,thiomycetin,thiophenicol,tiamfenicol,tiamfenicolo,urfamicina,urfamycine,vicemycetin"	1.5	"g"	1.5	"g"	"41723-8,41724-6,41725-3,54169-8"
 "TAT"	9568512	"Thioacetazone"	"Antimycobacterials"	"J04AK07"	"Drugs for treatment of tuberculosis"	"Other drugs for treatment of tuberculosis"	""	"aktivan,ambathizon,amithiozone,amitiozon,benthiozone,benzothiozane,benzothiozon,berculon a,berkazon,citazone,conteben,diasan,domakol,ilbion,livazone,mirizone neustab,mivizon,myvizone,neotibil,neustab,novakol,nuclon argentinian,panrone,parazone,seroden,siocarbazone,tebalon,tebecure,tebemar,tebesone i,tebethion,tebethione,tebezon,thiacetone,thiacetozone,thibon,thibone,thioacetazon,thioacetazone,thioacetazonum,thioazetazone,thiocarbazil,thiomicid,thionicid,thioparamizon,thioparamizone,thiosemicarbarzone,thiosemicarbazone,thiotebesin,thiotebezin,thiotebicina,thizone,tiacetazon,tibicur,tibion,tibione,tibizan,tibone,tioacetazon,tioacetazona,tioatsetazon,tiobicina,tiocarone,tiosecolo,tubercazon,tubigal"					""
 "THI1"		"Thioacetazone/isoniazid"	"Antimycobacterials"	"J04AM04"	"Drugs for treatment of tuberculosis"	"Combinations of drugs for treatment of tuberculosis"	""	""					""
-"TIA"	656958	"Tiamulin"	"Other antibacterials"	"NA"			""	"denagard,thiamutilin,tiamulin,tiamulin pamoate,tiamulina,tiamuline,tiamulinum,tiavet p"					"87589-8"
-"TIC"	36921	"Ticarcillin"	"Beta-lactams/penicillins"	"J01CA13"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"tc,ti,tic,tica"	"ticarcilina,ticarcillin,ticarcilline,ticarcillinum,ticillin,timentin"			15	"g"	"25254-4,4054-3,4055-0"
+"TIA"	656958	"Tiamulin"	"Other antibacterials"	"NA"			""	"denagard,thiamutilin,tiamulin,tiamulin pamoate,tiamulina,tiamuline,tiamulinum,tiavet p"					"35846-5,35847-3,35848-1,87589-8"
+"TIC"	36921	"Ticarcillin"	"Beta-lactams/penicillins"	"J01CA13"	"Beta-lactam antibacterials, penicillins"	"Penicillins with extended spectrum"	"tc,ti,tic,tica"	"ticarcilina,ticarcillin,ticarcilline,ticarcillinum,ticillin,timentin"			15	"g"	"18994-4,18995-1,25254-4,4054-3,4055-0,499-4,500-9,501-7,502-5,503-3,504-1,505-8,506-6,55716-5,55717-3,55718-1,55719-9,7053-2,7054-0"
 "TCC"	6437075	"Ticarcillin/clavulanic acid"	"Beta-lactams/penicillins"	"J01CR03"	"Beta-lactam antibacterials, penicillins"	"Combinations of penicillins, incl. beta-lactamase inhibitors"	"t/c,tcc,ticl,tim,tlc"	"timentin"			15	"g"	""
-"TGC"	54686904	"Tigecycline"	"Tetracyclines"	"J01AA12"	"Tetracyclines"	"Tetracyclines"	"tgc,tig,tige"	"haizheng li xing,tigeciclina,tigecyclin,tigecycline,tigecycline hydrate,tigecyclinum,tigilcycline,tygacil"			0.1	"g"	""
+"TGC"	54686904	"Tigecycline"	"Tetracyclines"	"J01AA12"	"Tetracyclines"	"Tetracyclines"	"tgc,tig,tige"	"haizheng li xing,tigeciclina,tigecyclin,tigecycline,tigecycline hydrate,tigecyclinum,tigilcycline,tygacil"			0.1	"g"	"101499-2,42354-1,42355-8,42356-6,42357-4,55158-0"
 "TBQ"	65592	"Tilbroquinol"	"Quinolones"	"P01AA05"			""	"tilbroquinol,tilbroquinolum"					""
-"TIP"	24860548	"Tildipirosin"	"Macrolides/lincosamides"	"NA"			""	"tildipirosin,zuprevo"					""
-"TIL"	5282521	"Tilmicosin"	"Macrolides/lincosamides"	"NA"			""	"micotil,pulmotil,tilmicosin,tilmicosina,tilmicosine,tilmicosinum"					"87588-0"
-"TIN"	5479	"Tinidazole"	"Other antibacterials"	"J01XD02,P01AB02"	"Other antibacterials"	"Imidazole derivatives"	"tini"	"amtiba,bioshik,ethyl sulfone,fasigin,fasigyn,fasigyntrade mark,fasygin,glongyn,haisigyn,pletil,simplotan,simplotantrade mark,sorquetan,symplotan,tindamax,tindamaxtrade mark,tinidazol,tinidazole,tinidazolum,tricolam,trimonase"	2	"g"	1.5	"g"	""
+"TIP"	24860548	"Tildipirosin"	"Macrolides/lincosamides"	"NA"			""	"tildipirosin,zuprevo"					"100060-3,88375-1,88377-7"
+"TIL"	5282521	"Tilmicosin"	"Macrolides/lincosamides"	"NA"			""	"micotil,pulmotil,tilmicosin,tilmicosina,tilmicosine,tilmicosinum"					"35849-9,35850-7,35851-5,87588-0"
+"TIN"	5479	"Tinidazole"	"Other antibacterials"	"J01XD02,P01AB02"	"Other antibacterials"	"Imidazole derivatives"	"tini"	"amtiba,bioshik,ethyl sulfone,fasigin,fasigyn,fasigyntrade mark,fasygin,glongyn,haisigyn,pletil,simplotan,simplotantrade mark,sorquetan,symplotan,tindamax,tindamaxtrade mark,tinidazol,tinidazole,tinidazolum,tricolam,trimonase"	2	"g"	1.5	"g"	"54928-7,55720-7,55721-5,55722-3"
 "TCR"	3001386	"Tiocarlide"	"Antimycobacterials"	"J04AD02"	"Drugs for treatment of tuberculosis"	"Thiocarbamide derivatives"	""	"amixyl,datanil,disocarban,disoxyl,isoxyl,thiocarlide,tiocarlid,tiocarlida,tiocarlide,tiocarlidum"	7	"g"			""
 "TDC"	10247721	"Tiodonium chloride"	"Other antibacterials"	"NA"			""	"cloruro de tiodonio,tiodonii chloridum,tiodonium chloride"					""
 "TXC"	65788	"Tioxacin"	"Quinolones"	"NA"			""	"tioxacin,tioxacine,tioxacino,tioxacinum,tioxic acid"					""
-"TIZ"	394397	"Tizoxanide"	"Other antibacterials"	"NA"			""	"ntzdes"					""
-"TOB"	36294	"Tobramycin"	"Aminoglycosides"	"J01GB01,S01AA12"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"nn,tm,to,tob,tobr"	"bethkis,brulamycin,deoxykanamycin b,distobram,gernebcin,gotabiotic,kitabis,kitabis pak,nebcin,nebicin,nebramycin,nebramycin vi,obramycin,sybryx,tenebrimycin,tenemycin,tobacin,tobi podhaler,tobracin,tobradex,tobradistin,tobralex,tobramaxin,tobramicin,tobramicina,tobramitsetin,tobramycetin,tobramycin,tobramycin base,tobramycin sulfate,tobramycine,tobramycinum,tobrased,tobrasone,tobrex"			0.24	"g"	"13584-8,17808-7,22750-4,22751-2,22752-0,31094-6,31095-3,31096-1,35239-3,35670-9,4057-6,4058-4,4059-2,50927-3,52962-8,59380-6,80966-5"
+"TIZ"	394397	"Tizoxanide"	"Other antibacterials"	"NA"			""	"ntzdes"					"73585-2,73607-4,73629-8"
+"TOB"	36294	"Tobramycin"	"Aminoglycosides"	"J01GB01,S01AA12"	"Aminoglycoside antibacterials"	"Other aminoglycosides"	"nn,tm,to,tob,tobr"	"bethkis,brulamycin,deoxykanamycin b,distobram,gernebcin,gotabiotic,kitabis,kitabis pak,nebcin,nebicin,nebramycin,nebramycin vi,obramycin,sybryx,tenebrimycin,tenemycin,tobacin,tobi podhaler,tobracin,tobradex,tobradistin,tobralex,tobramaxin,tobramicin,tobramicina,tobramitsetin,tobramycetin,tobramycin,tobramycin base,tobramycin sulfate,tobramycine,tobramycinum,tobrased,tobrasone,tobrex"			0.24	"g"	"101496-8,13584-8,17808-7,18996-9,22750-4,22751-2,22752-0,25227-0,25800-4,31094-6,31095-3,31096-1,35239-3,35670-9,4057-6,4058-4,4059-2,507-4,508-2,509-0,50927-3,510-8,52962-8,59380-6,7055-7,80966-5"
 "TOH"		"Tobramycin-high"	"Aminoglycosides"	"NA"			"tobra high,tobramycin high,tohl"	""					""
-"TFX"	5517	"Tosufloxacin"	"Quinolones"	"J01MA22"			""	"tosufloxacin"	0.45	"g"			""
-"TMP"	5578	"Trimethoprim"	"Trimethoprims"	"J01EA01"	"Sulfonamides and trimethoprim"	"Trimethoprim and derivatives"	"t,tmp,tr,tri,trim,w"	"abaprim,alprim,anitrim,antrima,antrimox,bacdan,bacidal,bacide,bacterial,bacticel,bactifor,bactin,bactoprim,bactramin,bactrim,bencole,bethaprim,biosulten,briscotrim,chemotrin,colizole,colizole ds,conprim,cotrimel,cotrimoxizole,deprim,dosulfin,duocide,esbesul,espectrin,euctrim,exbesul,fermagex,fortrim,idotrim,ikaprim,infectotrimet,instalac,kombinax,lagatrim,lagatrim forte,lastrim,lescot,methoprim,metoprim,monoprim,monotrim,monotrimin,novotrimel,omstat,oraprim,pancidim,polytrim,priloprim,primosept,primsol,proloprim,protrin,purbal,resprim,resprim forte,roubac,roubal,salvatrim,septrin ds,septrin forte,septrin s,setprin,sinotrim,stopan,streptoplus,sugaprim,sulfamar,sulfamethoprim,sulfoxaprim,sulthrim,sultrex,syraprim,tiempe,tmp smx,toprim,trimanyl,trimethioprim,trimethopim,trimethoprim,trimethoprime,trimethoprimum,trimethopriom,trimetoprim,trimetoprima,trimexazole,trimexol,trimezol,trimogal,trimono,trimopan,trimpex,triprim,trisul,trisulcom,trisulfam,trisural,uretrim,urobactrim,utetrin,velaten,wellcoprim,wellcoprin,xeroprim,zamboprim"	0.4	"g"	0.4	"g"	"11005-6,17747-7,25273-4,32342-8,4079-0,4080-8,4081-6,55584-7,80552-3,80973-1"
-"SXT"	358641	"Trimethoprim/sulfamethoxazole"	"Trimethoprims"	"J01EE01"	"Sulfonamides and trimethoprim"	"Combinations of sulfonamides and trimethoprim, incl. derivatives"	"cot,cotrim,sxt,t/s,trsu,trsx,ts"	"abacin,abactrim,agoprim,alfatrim,aposulfatrim,bacteral,bacterial forte,bactilen,bactiver,bacton,bactoreduct,bactrim,bactrim ds,bactrim forte,bactrim pediatric,bactrimel,bactrizol,bactromin,bactropin,baktar,belcomycine,berlocid,bibacrim,biseptol,chemitrim,chemotrim,ciplin,colimycin,colimycin sulphate,colisticin,colistimethate,colistimethate sodium,colistin sulfate,colistin sulphate,colomycin,coly-mycin,cotribene,cotrim d.s.,cotrim eu rho,cotrim holsen,cotrim.l.u.t.,cotrimaxazol,cotrimazole,cotrimhexal,cotrimoxazol,cotrimoxazol al,cotrimoxazole,cotrimstada,cotriver,dibaprim,drylin,duratrimet,eltrianyl,escoprim,esteprim,eusaprim,fectrim,gantaprim,gantaprin,gantrim,groprim,helveprim,imexim,jenamoxazol,kemoprim,kepinol,kepinol forte,laratrim,linaris,maxtrim,microtrim,microtrim forte,mikrosid,momentol,oecotrim,oriprim,oxaprim,pantoprim,polymyxin e,polymyxin e. sulfate,primazole,promixin,septra,septra ds,septra grape,septrim,septrin,servitrim,sigaprim,sigaprin,sulfatrim pediatric,sulfotrim,sulfotrimin,sulmeprim pediatric,sulprim,sumetrolim,supracombin,suprim,tacumil,teleprim,teleprin,thiocuran,totazina,tribakin,trifen,trigonyl,trimesulf,trimetho comp,trimethoprimsulfa,trimetoger,trimexazol,trimforte,trimosulfa,uroplus,uroplus ds,uroplus ss"					""
-"TRL"	202225	"Troleandomycin"	"Macrolides/lincosamides"	"J01FA08"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"acetyloleandomycin,aovine,cyclamycin,evramicina,matromicina,matromycin t,micotil,oleandocetine,oleandomycin,t.a.o.,treolmicina,tribiocillina,triocetin,triolan,troleandomicina,troleandomycin,troleandomycine,troleandomycinum,viamicina,wytrion"	1	"g"			""
+"TFX"	5517	"Tosufloxacin"	"Quinolones"	"J01MA22"			""	"tosufloxacin"	0.45	"g"			"100061-1,76146-0"
+"TMP"	5578	"Trimethoprim"	"Trimethoprims"	"J01EA01"	"Sulfonamides and trimethoprim"	"Trimethoprim and derivatives"	"t,tmp,tr,tri,trim,w"	"abaprim,alprim,anitrim,antrima,antrimox,bacdan,bacidal,bacide,bacterial,bacticel,bactifor,bactin,bactoprim,bactramin,bactrim,bencole,bethaprim,biosulten,briscotrim,chemotrin,colizole,colizole ds,conprim,cotrimel,cotrimoxizole,deprim,dosulfin,duocide,esbesul,espectrin,euctrim,exbesul,fermagex,fortrim,idotrim,ikaprim,infectotrimet,instalac,kombinax,lagatrim,lagatrim forte,lastrim,lescot,methoprim,metoprim,monoprim,monotrim,monotrimin,novotrimel,omstat,oraprim,pancidim,polytrim,priloprim,primosept,primsol,proloprim,protrin,purbal,resprim,resprim forte,roubac,roubal,salvatrim,septrin ds,septrin forte,septrin s,setprin,sinotrim,stopan,streptoplus,sugaprim,sulfamar,sulfamethoprim,sulfoxaprim,sulthrim,sultrex,syraprim,tiempe,tmp smx,toprim,trimanyl,trimethioprim,trimethopim,trimethoprim,trimethoprime,trimethoprimum,trimethopriom,trimetoprim,trimetoprima,trimexazole,trimexol,trimezol,trimogal,trimono,trimopan,trimpex,triprim,trisul,trisulcom,trisulfam,trisural,uretrim,urobactrim,utetrin,velaten,wellcoprim,wellcoprin,xeroprim,zamboprim"	0.4	"g"	0.4	"g"	"101495-0,11005-6,17747-7,18997-7,18998-5,20387-7,23614-1,23631-5,25273-4,32342-8,4079-0,4080-8,4081-6,511-6,512-4,513-2,514-0,515-7,516-5,517-3,518-1,55584-7,7056-5,7057-3,80552-3,80973-1"
+"SXT"	358641	"Trimethoprim/sulfamethoxazole"	"Trimethoprims"	"J01EE01"	"Sulfonamides and trimethoprim"	"Combinations of sulfonamides and trimethoprim, incl. derivatives"	"cot,cotrim,sxt,t/s,trsu,trsx,ts"	"abacin,abactrim,agoprim,alfatrim,aposulfatrim,bacteral,bacterial forte,bactilen,bactiver,bacton,bactoreduct,bactrim,bactrim ds,bactrim forte,bactrim pediatric,bactrimel,bactrizol,bactromin,bactropin,baktar,belcomycine,berlocid,bibacrim,biseptol,chemitrim,chemotrim,ciplin,colimycin,colimycin sulphate,colisticin,colistimethate,colistimethate sodium,colistin sulfate,colistin sulphate,colomycin,coly-mycin,cotribene,cotrim d.s.,cotrim eu rho,cotrim holsen,cotrim.l.u.t.,cotrimaxazol,cotrimazole,cotrimhexal,cotrimoxazol,cotrimoxazol al,cotrimoxazole,cotrimstada,cotriver,dibaprim,drylin,duratrimet,eltrianyl,escoprim,esteprim,eusaprim,fectrim,gantaprim,gantaprin,gantrim,groprim,helveprim,imexim,jenamoxazol,kemoprim,kepinol,kepinol forte,laratrim,linaris,maxtrim,microtrim,microtrim forte,mikrosid,momentol,oecotrim,oriprim,oxaprim,pantoprim,polymyxin e,polymyxin e. sulfate,primazole,promixin,septra,septra ds,septra grape,septrim,septrin,servitrim,sigaprim,sigaprin,sulfatrim pediatric,sulfotrim,sulfotrimin,sulmeprim pediatric,sulprim,sumetrolim,supracombin,suprim,tacumil,teleprim,teleprin,thiocuran,totazina,tribakin,trifen,trigonyl,trimesulf,trimetho comp,trimethoprimsulfa,trimetoger,trimexazol,trimforte,trimosulfa,uroplus,uroplus ds,uroplus ss"					"101495-0,18998-5,20387-7,23631-5,25273-4,32342-8,4081-6,515-7,516-5,517-3,518-1,7057-3"
+"TRL"	202225	"Troleandomycin"	"Macrolides/lincosamides"	"J01FA08"	"Macrolides, lincosamides and streptogramins"	"Macrolides"	""	"acetyloleandomycin,aovine,cyclamycin,evramicina,matromicina,matromycin t,micotil,oleandocetine,oleandomycin,t.a.o.,treolmicina,tribiocillina,triocetin,triolan,troleandomicina,troleandomycin,troleandomycine,troleandomycinum,viamicina,wytrion"	1	"g"			"18999-3,519-9,520-7,521-5,522-3"
 "TRO"	55886	"Trospectomycin"	"Other antibacterials"	"NA"			""	"rubidiumnitrate,trospectinomycin,trospectomicina,trospectomycin,trospectomycine,trospectomycinum"					""
-"TVA"	62959	"Trovafloxacin"	"Quinolones"	"J01MA13"	"Quinolone antibacterials"	"Fluoroquinolones"	"trov"	"trovafloxacin,trovan"	0.2	"g"	0.2	"g"	""
-"TUL"	9832301	"Tulathromycin"	"Macrolides/lincosamides"	"NA"			""	"draxxin,tulathrmycin a,tulathromycin,tulathromycin a"					""
-"TYL"	5280440	"Tylosin"	"Macrolides/lincosamides"	"NA"			""	"fradizine,tilosina,tylocine,tylosin,tylosin a,tylosine,tylosinum"					"87587-2"
-"TYL1"	6441094	"Tylvalosin"	"Macrolides/lincosamides"	"NA"			"tvn"	"tylvalosin"					""
+"TVA"	62959	"Trovafloxacin"	"Quinolones"	"J01MA13"	"Quinolone antibacterials"	"Fluoroquinolones"	"trov"	"trovafloxacin,trovan"	0.2	"g"	0.2	"g"	"23642-2,23643-0,35855-6,7058-1"
+"TUL"	9832301	"Tulathromycin"	"Macrolides/lincosamides"	"NA"			""	"draxxin,tulathrmycin a,tulathromycin,tulathromycin a"					"76149-4,87798-5"
+"TYL"	5280440	"Tylosin"	"Macrolides/lincosamides"	"NA"			""	"fradizine,tilosina,tylocine,tylosin,tylosin a,tylosine,tylosinum"					"35856-4,35857-2,35858-0,87587-2"
+"TYL1"	6441094	"Tylvalosin"	"Macrolides/lincosamides"	"NA"			"tvn"	"tylvalosin"					"101526-2,87586-4"
 "PRU1"	124225	"Ulifloxacin (Prulifloxacin)"	"Other antibacterials"	"NA"			""	"ulifloxacin"					""
-"VAN"	14969	"Vancomycin"	"Glycopeptides"	"A07AA09,J01XA01,S01AA28"	"Other antibacterials"	"Glycopeptide antibacterials"	"va,van,vanc"	"vancocin,vancocin hcl,vancoled,vancomicina,vancomycin,vancomycin hcl,vancomycine,vancomycinum,vancor,viomycin derivative"	2	"g"	2	"g"	"13586-3,13587-1,20578-1,31012-8,39092-2,39796-8,39797-6,4089-9,4090-7,4091-5,4092-3,50938-0,59381-4,97657-1"
+"VAN"	14969	"Vancomycin"	"Glycopeptides"	"A07AA09,J01XA01,S01AA28"	"Other antibacterials"	"Glycopeptide antibacterials"	"va,van,vanc"	"vancocin,vancocin hcl,vancoled,vancomicina,vancomycin,vancomycin hcl,vancomycine,vancomycinum,vancor,viomycin derivative"	2	"g"	2	"g"	"13586-3,13587-1,19000-9,20578-1,23615-8,25228-8,31012-8,39092-2,39796-8,39797-6,4089-9,4090-7,4091-5,4092-3,50938-0,523-1,524-9,525-6,526-4,59381-4,7059-9,92241-9,97657-1"
 "VAM"		"Vancomycin-macromethod"	"Glycopeptides"	"NA"			""	""					""
-"VIO"	135398671	"Viomycin"	"Antimycobacterials"	"NA"			""	"celiomycin,florimycin,floromycin,tuberactinomycin b,vinacetin a,vioactane,viomicina,viomycin,viomycine,viomycinum"					""
+"VIO"	135398671	"Viomycin"	"Antimycobacterials"	"NA"			""	"celiomycin,florimycin,floromycin,tuberactinomycin b,vinacetin a,vioactane,viomicina,viomycin,viomycine,viomycinum"					"19001-7,23616-6,527-2,528-0,529-8,530-6"
 "VIR"	11979535	"Virginiamycine"	"Other antibacterials"	"NA"			""	"eskalin,eskalin v,micamicina,mikamycin,mikamycine,mikamycinum,ostreogricina,ostreogrycin,ostreogrycine,ostreogrycinum,pristinamicina,pristinamycin,pristinamycine,pristinamycinum,pyostacine,stafac,stafytracine,staphylomycin,stapyocine,starfac,streptogramin,vernamycin,virgimycin,virgimycine,virginiamicina,virginiamycin,virginiamycina,virginiamycine,virginiamycinum"					""
-"VOR"	71616	"Voriconazole"	"Antifungals/antimycotics"	"J02AC03"	"Antimycotics for systemic use"	"Triazole derivatives"	"vori,vrc"	"pfizer,vfend i.v.,voriconazol,voriconazole,voriconazole vfend,voriconazolum,voriconzole,vorikonazole"	0.4	"g"	0.4	"g"	"38370-3,53902-3,73676-9,80553-1,80651-3"
+"VOR"	71616	"Voriconazole"	"Antifungals/antimycotics"	"J02AC03"	"Antimycotics for systemic use"	"Triazole derivatives"	"vori,vrc"	"pfizer,vfend i.v.,voriconazol,voriconazole,voriconazole vfend,voriconazolum,voriconzole,vorikonazole"	0.4	"g"	0.4	"g"	"32379-0,35862-2,35863-0,38370-3,41199-1,41200-7,53902-3,73676-9,80553-1,80651-3"
 "XBR"	72144	"Xibornol"	"Other antibacterials"	"J01XX02"	"Other antibacterials"	"Other antibacterials"	""	"bactacine,bracen,nanbacine,xibornol,xibornolo,xibornolum"					""
 "ZID"	77846445	"Zidebactam"	"Other antibacterials"	"NA"			""	"zidebactam"					""
 "ZFD"		"Zoliflodacin"		"NA"			""	"zoliflodacin"					""

data-raw/antivirals.txt

@@ -1,121 +1,121 @@
 "av"	"name"	"atc"	"cid"	"atc_group"	"synonyms"	"oral_ddd"	"oral_units"	"iv_ddd"	"iv_units"	"loinc"
-"ABA"	"Abacavir"	"J05AF06"	441300	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"abacavir sulfate,avacavir,ziagen"	0.6	"g"			"29113-8,78772-1,78773-9,79134-3,80118-3"
+"ABA"	"Abacavir"	"J05AF06"	441300	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"abacavir sulfate,avacavir,ziagen"	0.6	"g"			"29113-8,30273-7,30287-7,30303-2,78772-1,78773-9,79134-3,80118-3"
 "ACI"	"Aciclovir"	"J05AB01"	135398513	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"acicloftal,aciclovier,aciclovirum,activir,acyclofoam,acycloguanosine,acyclovir,acyclovir lauriad,avaclyr,cargosil,cyclovir,genvir,gerpevir,hascovir,maynar,novirus,poviral,sitavig,sitavir,vipral,viropump,virorax,zovirax,zyclir"	4	"g"	4	"g"	""
 "ADD"	"Adefovir dipivoxil"	"J05AF08"	60871	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"adefovir di,adefovir di ester,adefovir dipivoxyl,adefovir pivoxil,adefovirdipivoxl,bisadenine,bispmea,hepsera,preveon,youheding"	10	"mg"			""
 "AME"	"Amenamevir"	"J05AX26"	11397521	"Other antivirals"	"amenalief"	0.4	"g"			""
-"AMP"	"Amprenavir"	"J05AE05"	65016	"Protease inhibitors"	"agenerase,carbamate,prozei"	1.2	"g"			"29114-6,31028-4,78791-1"
+"AMP"	"Amprenavir"	"J05AE05"	65016	"Protease inhibitors"	"agenerase,carbamate,prozei"	1.2	"g"			"29114-6,30296-8,30297-6,30299-2,31028-4,49623-2,78791-1"
 "ASU"	"Asunaprevir"	"J05AP06"	16076883	"Antivirals for treatment of HCV infections"	"sunvepra,sunvepratrade"	0.2	"g"			""
-"ATA"	"Atazanavir"	"J05AE08"	148192	"Protease inhibitors"	"atazanavir base,latazanavir,reyataz,zrivada"	0.3	"g"			"41470-6,78796-0,78797-8,80142-3,80143-1"
+"ATA"	"Atazanavir"	"J05AE08"	148192	"Protease inhibitors"	"atazanavir base,latazanavir,reyataz,zrivada"	0.3	"g"			"41403-7,41470-6,41993-7,49618-2,49668-7,57907-8,78796-0,78797-8,80142-3,80143-1"
 "ATA+COBI"	"Atazanavir/cobicistat"	"J05AR15"	86583336	"Antivirals for treatment of HIV infections, combinations"	""					""
-"ATA+RIT"	"Atazanavir/ritonavir"	"J05AR23"	25134325	"Antivirals for treatment of HIV infections, combinations"	""	0.3	"g"			""
+"ATA+RIT"	"Atazanavir/ritonavir"	"J05AR23"	25134325	"Antivirals for treatment of HIV infections, combinations"	""	0.3	"g"			"49618-2,57907-8"
 "BAM"	"Baloxavir marboxil"	"J05AX25"	124081896	"Other antivirals"	"xofluza"	40	"mg"			""
-"BOC"	"Boceprevir"	"J05AP03"	10324367	"Antivirals for treatment of HCV infections"	"victrelis"	2.4	"g"			""
+"BOC"	"Boceprevir"	"J05AP03"	10324367	"Antivirals for treatment of HCV infections"	"victrelis"	2.4	"g"			"72859-2"
 "BRIN"	"Brincidofovir"	"J05AB17"	483477	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"cidofovir prodrug,tembexa"					""
 "BRIV"	"Brivudine"	"J05AB15"	446727	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"bridic,brivox,brivudin,brivudina,brivudinum,brvdurd,helpin,zerpex,zostex"	0.125	"g"			""
 "BUL"	"Bulevirtide"	"J05AX28"		"Other antivirals"	""					""
-"CAB"	"Cabotegravir"	"J05AJ04"	54713659	"Integrase inhibitors"	"cabenuva"	30	"mg"	10	"mg"	""
-"CID"	"Cidofovir"	"J05AB12"	60613	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"cidofovir anhydrous,cidofovir gel,cidofovir hydrate,cidofovirum,forvade,hpmpc dihydrate,phosphonic acid,vistide"			25	"mg"	""
+"CAB"	"Cabotegravir"	"J05AJ04"	54713659	"Integrase inhibitors"	"cabenuva"	30	"mg"	10	"mg"	"96566-5"
+"CID"	"Cidofovir"	"J05AB12"	60613	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"cidofovir anhydrous,cidofovir gel,cidofovir hydrate,cidofovirum,forvade,hpmpc dihydrate,phosphonic acid,vistide"			25	"mg"	"33628-9,72855-0,72856-8"
 "CLE"	"Clevudine"	"J05AF12"	73115	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"levovir,revovir"	30	"mg"			""
 "COBL"	"Coblopasvir"	"J05AP12"	58316387	"Antivirals for treatment of HCV infections"	""					""
-"DAC"	"Daclatasvir"	"J05AP07"	25154714	"Antivirals for treatment of HCV infections"	"daklinza"	60	"mg"			""
+"DAC"	"Daclatasvir"	"J05AP07"	25154714	"Antivirals for treatment of HCV infections"	"daklinza"	60	"mg"			"82379-9"
 "DAC+ASU+BEC"	"Daclatasvir/asunaprevir/beclabuvir"	"J05AP58"		"Antivirals for treatment of HCV infections"	""					""
-"DAR"	"Darunavir"	"J05AE10"	213039	"Protease inhibitors"	"carbamate,darunavirum,derunavir,prezista,prezista naive"	1.2	"g"			"57954-0"
+"DAR"	"Darunavir"	"J05AE10"	213039	"Protease inhibitors"	"carbamate,darunavirum,derunavir,prezista,prezista naive"	1.2	"g"			"49630-7,49666-1,55091-3,57954-0,57955-7"
 "DAR+COBI"	"Darunavir/cobicistat"	"J05AR14"	57327017	"Antivirals for treatment of HIV infections, combinations"	""					""
-"DAR+RIT"	"Darunavir/ritonavir"	"J05AR26"		"Antivirals for treatment of HIV infections, combinations"	""					""
+"DAR+RIT"	"Darunavir/ritonavir"	"J05AR26"		"Antivirals for treatment of HIV infections, combinations"	""					"49630-7,57955-7"
 "DAS"	"Dasabuvir"	"J05AP09"	56640146	"Antivirals for treatment of HCV infections"	""	0.5	"g"			""
 "DAS+OMB+PAR+RIT"	"Dasabuvir/ombitasvir/paritaprevir/ritonavir"	"J05AP52"		"Antivirals for treatment of HCV infections"	""					""
-"DEL"	"Delavirdine"	"J05AG02"	5625	"Non-nucleoside reverse transcriptase inhibitors"	"piperazine,rescriptor"	1.2	"g"			"27082-7,29115-3"
-"DID"	"Didanosine"	"J05AF02"	135398739	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"didanosina,didanosinum,dideoxyinosine,hypoxanthine ddn,videx ec"	0.4	"g"			"29116-1,48307-3"
-"DOL"	"Dolutegravir"	"J05AJ03"	54726191	"Integrase inhibitors"	"dolutegravir  dtg,soltegravir,tivicay"	50	"mg"			""
+"DEL"	"Delavirdine"	"J05AG02"	5625	"Non-nucleoside reverse transcriptase inhibitors"	"piperazine,rescriptor"	1.2	"g"			"27082-7,29115-3,30276-0,30290-1,30305-7"
+"DID"	"Didanosine"	"J05AF02"	135398739	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"didanosina,didanosinum,dideoxyinosine,hypoxanthine ddn,videx ec"	0.4	"g"			"29116-1,30270-3,30284-4,30300-8,48307-3"
+"DOL"	"Dolutegravir"	"J05AJ03"	54726191	"Integrase inhibitors"	"dolutegravir  dtg,soltegravir,tivicay"	50	"mg"			"101412-5,72857-6"
 "DOL+RIL"	"Dolutegravir/rilpivirine"	"J05AR21"	131801472	"Antivirals for treatment of HIV infections, combinations"	""					""
-"DOR"	"Doravirine"	"J05AG06"	58460047	"Non-nucleoside reverse transcriptase inhibitors"	"pifeltro"	0.1	"g"			""
-"EFA"	"Efavirenz"	"J05AG03"	64139	"Non-nucleoside reverse transcriptase inhibitors"	"efavirenz teva,efavirenzum,eravirenz,stocrin,strocin,sustiva,viraday"	0.6	"g"			"29117-9,33928-3,51907-4,51908-2"
-"ELB"	"Elbasvir"	"J05AP10"	71661251	"Antivirals for treatment of HCV infections"	"methyl carbamate"	50	"mg"			""
+"DOR"	"Doravirine"	"J05AG06"	58460047	"Non-nucleoside reverse transcriptase inhibitors"	"pifeltro"	0.1	"g"			"91897-9"
+"EFA"	"Efavirenz"	"J05AG03"	64139	"Non-nucleoside reverse transcriptase inhibitors"	"efavirenz teva,efavirenzum,eravirenz,stocrin,strocin,sustiva,viraday"	0.6	"g"			"29117-9,30277-8,30291-9,30306-5,33928-3,51907-4,51908-2"
+"ELB"	"Elbasvir"	"J05AP10"	71661251	"Antivirals for treatment of HCV infections"	"methyl carbamate"	50	"mg"			"82376-5"
 "ELB+GRA"	"Elbasvir/grazoprevir"	"J05AP54"	91669168	"Antivirals for treatment of HCV infections"	"zepatier"					""
-"ELV"	"Elvitegravir"	"J05AJ02"	5277135	"Integrase inhibitors"	"vitekta"					"88986-5"
-"EMT"	"Emtricitabine"	"J05AF09"	60877	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"coviracil,emtricitabinum,emtritabine,emtriva,racivir"	0.2	"g"			""
+"ELV"	"Elvitegravir"	"J05AJ02"	5277135	"Integrase inhibitors"	"vitekta"					"72526-7,88986-5"
+"EMT"	"Emtricitabine"	"J05AF09"	60877	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"coviracil,emtricitabinum,emtritabine,emtriva,racivir"	0.2	"g"			"41402-9,49669-5"
 "EMT+TEA"	"Emtricitabine/tenofovir alafenamide"	"J05AR17"	90469070	"Antivirals for treatment of HIV infections, combinations"	"descovy"					""
 "EMT+TEA+BIC"	"Emtricitabine/tenofovir alafenamide/bictegravir"	"J05AR20"		"Antivirals for treatment of HIV infections, combinations"	""					""
-"EMT+TEA+RIL"	"Emtricitabine/tenofovir alafenamide/rilpivirine"	"J05AR19"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "EMT+TEA+DAR+COBI"	"Emtricitabine/tenofovir alafenamide/darunavir/cobicistat"	"J05AR22"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "EMT+TEA+ELV+COBI"	"Emtricitabine/tenofovir alafenamide/elvitegravir/cobicistat"	"J05AR18"		"Antivirals for treatment of HIV infections, combinations"	""					""
+"EMT+TEA+RIL"	"Emtricitabine/tenofovir alafenamide/rilpivirine"	"J05AR19"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "EMT+TED+EFA"	"Emtricitabine/tenofovir disoproxil/efavirenz"	"J05AR06"		"Antivirals for treatment of HIV infections, combinations"	""					""
-"EMT+TED+RIL"	"Emtricitabine/tenofovir disoproxil/rilpivirine"	"J05AR08"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "EMT+TED+ELV+COBI"	"Emtricitabine/tenofovir disoproxil/elvitegravir/cobicistat"	"J05AR09"		"Antivirals for treatment of HIV infections, combinations"	""					""
-"ENF"	"Enfuvirtide"	"J05AX07"	16130199	"Other antivirals"	"enfurvitide,fuzeon,pentafuside"			0.18	"g"	""
+"EMT+TED+RIL"	"Emtricitabine/tenofovir disoproxil/rilpivirine"	"J05AR08"		"Antivirals for treatment of HIV infections, combinations"	""					""
+"ENF"	"Enfuvirtide"	"J05AX07"	16130199	"Other antivirals"	"enfurvitide,fuzeon,pentafuside"			0.18	"g"	"72858-4,82719-6"
 "ENI"	"Enisamium iodide"	"J05AX17"	10089466	"Other antivirals"	"amizon"	1.5	"g"			""
-"ENT"	"Entecavir"	"J05AF10"	135398508	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"baraclude,entecavir anhydrous"	0.5	"mg"			""
-"ETR"	"Etravirine"	"J05AG04"	193962	"Non-nucleoside reverse transcriptase inhibitors"	"dapy deriv,etravine,intelence"	0.4	"g"			"57961-5"
+"ENT"	"Entecavir"	"J05AF10"	135398508	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"baraclude,entecavir anhydrous"	0.5	"mg"			"56791-7"
+"ETR"	"Etravirine"	"J05AG04"	193962	"Non-nucleoside reverse transcriptase inhibitors"	"dapy deriv,etravine,intelence"	0.4	"g"			"52749-9,57961-5,72558-0"
 "FAL"	"Faldaprevir"	"J05AP04"	42601552	"Antivirals for treatment of HCV infections"	""					""
-"FAM"	"Famciclovir"	"J05AB09"	3324	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"famciclovirum,famvir,oravir"	0.75	"g"			""
+"FAM"	"Famciclovir"	"J05AB09"	3324	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"famciclovirum,famvir,oravir"	0.75	"g"			"72839-4"
 "FAV"	"Favipiravir"	"J05AX27"	492405	"Other antivirals"	"avigan,fapilavir,favilavir"	1.6	"g"			""
-"FOSA"	"Fosamprenavir"	"J05AE07"	131536	"Protease inhibitors"	"amprenavir phosphate,carbamate,lexiva,telzir"	1.4	"g"			""
-"FOSC"	"Foscarnet"	"J05AD01"	3415	"Phosphonic acid derivatives"	"forscarnet,foscarmet,foscavir,phosphonoformate,phosphonoformic acid"			6.5	"g"	""
+"FOSA"	"Fosamprenavir"	"J05AE07"	131536	"Protease inhibitors"	"amprenavir phosphate,carbamate,lexiva,telzir"	1.4	"g"			"42500-9,43736-8,51409-1,57965-6"
+"FOSC"	"Foscarnet"	"J05AD01"	3415	"Phosphonic acid derivatives"	"forscarnet,foscarmet,foscavir,phosphonoformate,phosphonoformic acid"			6.5	"g"	"256-8,42317-8,72834-5"
 "FOSF"	"Fosfonet"	"J05AD02"	546	"Phosphonic acid derivatives"	"fosfonet sodium,fosfonoacetate,fosfonoacetic acid,phosphonacetate,phosphonacetic acid,phosphonoaceticacid"					""
 "FOST"	"Fostemsavir"	"J05AX29"	11319217	"Other antivirals"	"rukobia"	1.2	"g"			""
-"GAN"	"Ganciclovir"	"J05AB06"	135398740	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"citovirax,cymevan,cymeven,cymevene,cytovene,ganciclovirum,gancyclovir,hydroxyacyclovir,virgan,vitrasert,zirgan"	3	"g"	0.5	"g"	"15367-6,25256-9,59798-9,59799-7,60077-5,60078-3"
+"GAN"	"Ganciclovir"	"J05AB06"	135398740	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"citovirax,cymevan,cymeven,cymevene,cytovene,ganciclovirum,gancyclovir,hydroxyacyclovir,virgan,vitrasert,zirgan"	3	"g"	0.5	"g"	"15367-6,25256-9,265-9,59798-9,59799-7,60077-5,60078-3,72854-3,72861-8"
 "GLE+PIB"	"Glecaprevir/pibrentasvir"	"J05AP57"	85471918	"Antivirals for treatment of HCV infections"	""					""
-"GRA"	"Grazoprevir"	"J05AP11"	44603531	"Antivirals for treatment of HCV infections"	""	0.1	"g"			""
+"GRA"	"Grazoprevir"	"J05AP11"	44603531	"Antivirals for treatment of HCV infections"	""	0.1	"g"			"82523-2"
 "IBA"	"Ibalizumab"	"J05AX23"		"Other antivirals"	""					""
 "IDO"	"Idoxuridine"	"J05AB02"	5905	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"antizona,dendrid,heratil,herplex,idossuridina,idoxene,idoxuridin,idoxuridina,idoxuridinum,iduoculos,iduridin,iododeoxyridine,iododeoxyuridine,iodoxuridine,joddeoxiuridin,kerecid,stoxil,virudox"					""
-"IND"	"Indinavir"	"J05AE02"	5362440	"Protease inhibitors"	"compound j,crixivan,indinavir anhydrous,propolis+indinavir"	2.4	"g"			"29118-7,31033-4,51918-1"
+"IND"	"Indinavir"	"J05AE02"	5362440	"Protease inhibitors"	"compound j,crixivan,indinavir anhydrous,propolis+indinavir"	2.4	"g"			"29118-7,30278-6,30292-7,30307-3,31033-4,49619-0,51918-1,57984-7"
 "INP"	"Inosine pranobex"	"J05AX05"	135449284	"Other antivirals"	"aviral,delimmun,groprinosin,immunovir,imunovir,imunoviral,inosiplex,isoprinosin,isoprinosina,isoprinosine,isoviral,methisoprinol,modimmunal,pranosina,pranosine,viruxan"	3	"g"			""
-"LAM"	"Lamivudine"	"J05AF05"	60825	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"epivir,hepitec,heptivir,heptodin,heptovir,lamivir,lamivudeine,lamivudine teva,lamivudinum,virolam,zeffix"	0.3	"g"			"29119-5,49226-4"
+"LAM"	"Lamivudine"	"J05AF05"	60825	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"epivir,hepitec,heptivir,heptodin,heptovir,lamivir,lamivudeine,lamivudine teva,lamivudinum,virolam,zeffix"	0.3	"g"			"29119-5,30269-5,30283-6,30298-4,49226-4,49620-8"
 "LAM+ABA"	"Lamivudine/abacavir"	"J05AR02"		"Antivirals for treatment of HIV infections, combinations"	""					""
+"LAM+ABA+DOL"	"Lamivudine/abacavir/dolutegravir"	"J05AR13"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "LAM+DOL"	"Lamivudine/dolutegravir"	"J05AR25"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "LAM+RAL"	"Lamivudine/raltegravir"	"J05AR16"	73386700	"Antivirals for treatment of HIV infections, combinations"	""					""
 "LAM+TED"	"Lamivudine/tenofovir disoproxil"	"J05AR12"		"Antivirals for treatment of HIV infections, combinations"	""					""
-"LAM+ABA+DOL"	"Lamivudine/abacavir/dolutegravir"	"J05AR13"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "LAM+TED+DOL"	"Lamivudine/tenofovir disoproxil/dolutegravir"	"J05AR27"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "LAM+TED+DOR"	"Lamivudine/tenofovir disoproxil/doravirine"	"J05AR24"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "LAM+TED+EFA"	"Lamivudine/tenofovir disoproxil/efavirenz"	"J05AR11"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "LAN"	"Laninamivir"	"J05AH04"	502272	"Neuraminidase inhibitors"	""					""
 "LEN"	"Lenacapavir"	"J05AX31"	133082658	"Other antivirals"	""					""
 "LET"	"Letermovir"	"J05AX18"	45138674	"Other antivirals"	"acetic acid,prevymis"	0.48	"g"	0.48	"g"	""
-"LOP+RIT"	"Lopinavir/ritonavir"	"J05AR10"	11979606	"Antivirals for treatment of HIV infections, combinations"	"aluvia,kaletra,lopimune"	0.8	"g"			""
+"LOP+RIT"	"Lopinavir/ritonavir"	"J05AR10"	11979606	"Antivirals for treatment of HIV infections, combinations"	"aluvia,kaletra,lopimune"	0.8	"g"			"42000-0,57997-9"
 "LYS"	"Lysozyme"	"J05AX02"	16130991	"Other antivirals"	""					""
 "MARA"	"Maraviroc"	"J05AX09"	3002977	"Other antivirals"	"celsentri,selzentry"	0.6	"g"			"88987-3"
-"MARI"	"Maribavir"	"J05AX10"	471161	"Other antivirals"	"benzimidavir,camvia"					""
+"MARI"	"Maribavir"	"J05AX10"	471161	"Other antivirals"	"benzimidavir,camvia"					"72853-5"
 "MET"	"Metisazone"	"J05AA01"	667492	"Thiosemicarbazones"	"kemoviran,marboran,marborane,methisazon,methisazone,methsazone,metisazon,metisazona,metisazonum,viruzona"					""
 "MOR"	"Moroxydine"	"J05AX01"	71655	"Other antivirals"	"bimolin,moroxidina,moroxydinum,virugon,virumin,wirumin"	0.3	"g"			""
-"NEL"	"Nelfinavir"	"J05AE04"	64143	"Protease inhibitors"	"viracept"	2.25	"g"			"29120-3,32647-0,35113-0,51923-1"
-"NEV"	"Nevirapine"	"J05AG01"	4463	"Non-nucleoside reverse transcriptase inhibitors"	"nevirapine anhydrous,nevirapine teva,nevirapine),viramune,viramune ir,viramune xr"	0.4	"g"			"29121-1,32646-2,51925-6"
+"NEL"	"Nelfinavir"	"J05AE04"	64143	"Protease inhibitors"	"viracept"	2.25	"g"			"29120-3,30280-2,30294-3,30309-9,32647-0,35113-0,51923-1"
+"NEV"	"Nevirapine"	"J05AG01"	4463	"Non-nucleoside reverse transcriptase inhibitors"	"nevirapine anhydrous,nevirapine teva,nevirapine),viramune,viramune ir,viramune xr"	0.4	"g"			"29121-1,30275-2,30289-3,30311-5,32646-2,51925-6"
 "OMB+PAR+RIT"	"Ombitasvir/paritaprevir/ritonavir"	"J05AP53"		"Antivirals for treatment of HCV infections"	""					""
-"OSE"	"Oseltamivir"	"J05AH02"	65028	"Neuraminidase inhibitors"	"agucort,tamiflu,tamvir"	0.15	"g"			""
+"OSE"	"Oseltamivir"	"J05AH02"	65028	"Neuraminidase inhibitors"	"agucort,tamiflu,tamvir"	0.15	"g"			"60440-5,60441-3"
 "PEN"	"Penciclovir"	"J05AB13"	135398748	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"adenovir,denavir,penciceovir,penciclovirum,pencyclovir,vectavir"					"60140-1,60141-9"
 "PAIE"	"Pentanedioic acid imidazolyl ethanamide"	"J05AX21"	9942657	"Other antivirals"	"ingamine"	90	"mg"			""
 "PER"	"Peramivir"	"J05AH03"	154234	"Neuraminidase inhibitors"	"peramiflu,peramivir anhydrous,rapiacta,rapivab"			0.6	"g"	""
 "PLE"	"Pleconaril"	"J05AX06"	1684	"Other antivirals"	"picovir,pleconarilis"					""
-"RAL"	"Raltegravir"	"J05AJ01"	54671008	"Integrase inhibitors"	"isentress"	0.8	"g"			"72835-2"
+"RAL"	"Raltegravir"	"J05AJ01"	54671008	"Integrase inhibitors"	"isentress"	0.8	"g"			"61198-8,72525-9,72835-2"
 "REM"	"Remdesivir"	"J05AB16"	121304016	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"veklury"			0.1	"g"	""
 "RIB"	"Ribavirin"	"J05AP01"	37542	"Antivirals for treatment of HCV infections"	"copegus,cotronak,ravanex,rebetol,rebetron,rebretron,ribacine,ribamide,ribamidil,ribamidyl,ribasphere,ribavirin capsules,ribavirin mylan,ribavirin teva,ribavirina,ribavirine,ribavirinum,tribavirin,varazid,vilona,viramid,virazid,virazide,virazole"	1	"g"			"41469-8"
-"RIL"	"Rilpivirine"	"J05AG05"	6451164	"Non-nucleoside reverse transcriptase inhibitors"	"edurant,rilpivirina"	25	"mg"	15	"mg"	"80547-3"
+"RIL"	"Rilpivirine"	"J05AG05"	6451164	"Non-nucleoside reverse transcriptase inhibitors"	"edurant,rilpivirina"	25	"mg"	15	"mg"	"68463-9,72557-2,80547-3"
 "RIM"	"Rimantadine"	"J05AC02"	5071	"Cyclic amines"	"ethanamine,rimant,rimantadin,rimantadin a,rimantadina,rimantadinum"	0.2	"g"			""
-"RIT"	"Ritonavir"	"J05AE03"	392622	"Protease inhibitors"	"empetus,norvir,norvir softgel,ritomune,ritonavirum,ritovir,viekirax,viriton"	1.2	"g"			"29122-9,31027-6,51929-8,51930-6"
-"SAQ"	"Saquinavir"	"J05AE01"	441243	"Protease inhibitors"	"fortovase,invirase,saquinavirum"	1.8	"g"			"19051-2,29123-7,51932-2"
-"SIM"	"Simeprevir"	"J05AP05"	24873435	"Antivirals for treatment of HCV infections"	"olysio,simeprevir sodium"	0.15	"g"			""
-"SOF"	"Sofosbuvir"	"J05AP08"	45375808	"Antivirals for treatment of HCV infections"	"hepcinat,hepcvir,sovaldi,sovihep"	0.4	"g"			""
+"RIT"	"Ritonavir"	"J05AE03"	392622	"Protease inhibitors"	"empetus,norvir,norvir softgel,ritomune,ritonavirum,ritovir,viekirax,viriton"	1.2	"g"			"29122-9,30279-4,30293-5,30308-1,31027-6,51929-8,51930-6"
+"SAQ"	"Saquinavir"	"J05AE01"	441243	"Protease inhibitors"	"fortovase,invirase,saquinavirum"	1.8	"g"			"19051-2,29123-7,30281-0,30295-0,30310-7,49621-6,51932-2,58024-1"
+"SIM"	"Simeprevir"	"J05AP05"	24873435	"Antivirals for treatment of HCV infections"	"olysio,simeprevir sodium"	0.15	"g"			"82522-4"
+"SOF"	"Sofosbuvir"	"J05AP08"	45375808	"Antivirals for treatment of HCV infections"	"hepcinat,hepcvir,sovaldi,sovihep"	0.4	"g"			"82382-3"
 "SOF+LED"	"Sofosbuvir/ledipasvir"	"J05AP51"	72734365	"Antivirals for treatment of HCV infections"	"harvoni"					""
 "SOF+VEL"	"Sofosbuvir/velpatasvir"	"J05AP55"	91885554	"Antivirals for treatment of HCV infections"	"epclusa,epclusa tablet"					""
 "SOF+VEL+VOX"	"Sofosbuvir/velpatasvir/voxilaprevir"	"J05AP56"		"Antivirals for treatment of HCV infections"	""					""
-"STA"	"Stavudine"	"J05AF04"	18283	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"estavudina,sanilvudine,stavudinum,zerit xr,zerut xr"	80	"mg"			"29124-5,49227-2"
+"STA"	"Stavudine"	"J05AF04"	18283	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"estavudina,sanilvudine,stavudinum,zerit xr,zerut xr"	80	"mg"			"29124-5,30272-9,30286-9,30302-4,49227-2"
 "STA+LAM+NEV"	"Stavudine/lamivudine/nevirapine"	"J05AR07"	15979285	"Antivirals for treatment of HIV infections, combinations"	""					""
 "TEC"	"Tecovirimat"	"J05AX24"	16124688	"Other antivirals"	""					""
-"TELA"	"Telaprevir"	"J05AP02"	3010818	"Antivirals for treatment of HCV infections"	"incivek,incivo,telavic"	2.25	"g"			""
-"TELB"	"Telbivudine"	"J05AF11"	159269	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"epavudine,sebivo,telbivudin,tyzeka"	0.6	"g"			""
+"TELA"	"Telaprevir"	"J05AP02"	3010818	"Antivirals for treatment of HCV infections"	"incivek,incivo,telavic"	2.25	"g"			"72860-0"
+"TELB"	"Telbivudine"	"J05AF11"	159269	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"epavudine,sebivo,telbivudin,tyzeka"	0.6	"g"			"56792-5"
 "TEA"	"Tenofovir alafenamide"	"J05AF13"	9574768	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"vemlidy"	25	"mg"			""
 "TED"	"Tenofovir disoproxil"	"J05AF07"	5481350	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"bispmpa,pmpa prodrug,tenofovir,tenofovir bis,tenofovirdisoproxil,viread"	0.245	"g"			""
 "TED+EMT"	"Tenofovir disoproxil/emtricitabine"	"J05AR03"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "TIL"	"Tilorone"	"J05AX19"	5475	"Other antivirals"	"amixin ic,tiloron,tilorona,tiloronum"	0.125	"g"			""
-"TIP"	"Tipranavir"	"J05AE09"	54682461	"Protease inhibitors"	"aptivus"	1	"g"			"57383-2"
+"TIP"	"Tipranavir"	"J05AE09"	54682461	"Protease inhibitors"	"aptivus"	1	"g"			"42535-5,43737-6,49622-4,49667-9,57383-2,58029-0"
 "TRO"	"Tromantadine"	"J05AC03"	64377	"Cyclic amines"	"tromantadina,tromantadinum"					""
 "UMI"	"Umifenovir"	"J05AX13"	131411	"Other antivirals"	"arbidol,arbidol base"	0.8	"g"			""
 "VALA"	"Valaciclovir"	"J05AB11"	135398742	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"talavir,valacv,valacyclovir,valcivir,valcyclovir,valtrex,virval,zelitrex"	3	"g"			""
 "VALG"	"Valganciclovir"	"J05AB14"	135413535	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"cymeval"	0.9	"g"			"74960-6"
 "VID"	"Vidarabine"	"J05AB03"	21704	"Nucleosides and nucleotides excl. reverse transcriptase inhibitors"	"adenine arabinoside,araadenosine,arabinoside adenine,arabinosyl adenine,arabinosyladenine,spongoadenosine,vidarabin,vidarabina,vidarabine anhydrous,vidarabinum,vira a,vira atm"			0.7	"g"	""
-"ZAL"	"Zalcitabine"	"J05AF03"	24066	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"dideoxycytidine,interferon ad + ddc,zalcitibine"	2.25	"mg"			"29125-2"
-"ZAN"	"Zanamivir"	"J05AH01"	60855	"Neuraminidase inhibitors"	"modified sialic acid,relenza,zanamavir,zanamivi,zanamivirhydrate"			1.2	"g"	""
-"ZID"	"Zidovudine"	"J05AF01"	35370	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"azidothymidine,beta interferon,compound s,propolis+azt,retrovir,trizivir,zidovudina,zidovudinum"	0.6	"g"	0.6	"g"	"29126-0,6894-0"
+"ZAL"	"Zalcitabine"	"J05AF03"	24066	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"dideoxycytidine,interferon ad + ddc,zalcitibine"	2.25	"mg"			"29125-2,30271-1,30285-1,30301-6"
+"ZAN"	"Zanamivir"	"J05AH01"	60855	"Neuraminidase inhibitors"	"modified sialic acid,relenza,zanamavir,zanamivi,zanamivirhydrate"			1.2	"g"	"75029-9"
+"ZID"	"Zidovudine"	"J05AF01"	35370	"Nucleoside and nucleotide reverse transcriptase inhibitors"	"azidothymidine,beta interferon,compound s,propolis+azt,retrovir,trizivir,zidovudina,zidovudinum"	0.6	"g"	0.6	"g"	"29126-0,30268-7,30282-8,531-4,6894-0"
 "ZID+LAM"	"Zidovudine/lamivudine"	"J05AR01"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "ZID+LAM+ABA"	"Zidovudine/lamivudine/abacavir"	"J05AR04"		"Antivirals for treatment of HIV infections, combinations"	""					""
 "ZID+LAM+NEV"	"Zidovudine/lamivudine/nevirapine"	"J05AR05"		"Antivirals for treatment of HIV infections, combinations"	""					""

data-raw/av.md5

@@ -1 +1 @@
-009fea3738cdb6390dccd470cb27f015
+1bb751091ed77d3d8c8c0ccad3583483

data-raw/clin_break.md5

@@ -1 +1 @@
-b0c1c3ddb9f8a23aedff6208e9f8d32a
+c4a5519e0ecc74220fc768e944a372f7

data-raw/clinical_breakpoints.txt

@@ -15699,7 +15699,7 @@
 "CLSI 2023"	"human"	"DISK"		"B_[ORD]_ENTRBCTR"	5	"PLZ"	"Table 2A"	"30ug"	18	14	FALSE
 "CLSI 2023"	"human"	"MIC"		"B_[ORD]_ENTRBCTR"	5	"PLZ"	"Table 2A"		2	8	FALSE
 "CLSI 2023"	"human"	"DISK"		"B_[ORD]_ENTRBCTR"	5	"SAM"	"Table 2A"	"10ug/10ug"	15	11	FALSE
-"CLSI 2023"	"human"	"MIC"		"B_[ORD]_ENTRBCTR"	5	"SAM"	"Table 2A"		16	32	FALSE
+"CLSI 2023"	"human"	"MIC"		"B_[ORD]_ENTRBCTR"	5	"SAM"	"Table 2A"		8	32	FALSE
 "CLSI 2023"	"human"	"DISK"		"B_[ORD]_ENTRBCTR"	5	"SMX"	"Table 2A"	"200ug/300ug"	17	12	FALSE
 "CLSI 2023"	"human"	"MIC"		"B_[ORD]_ENTRBCTR"	5	"SMX"	"Table 2A"		256	512	FALSE
 "CLSI 2023"	"human"	"DISK"		"B_[ORD]_ENTRBCTR"	5	"SOX"	"Table 2A"	"200ug/300ug"	17	12	FALSE

data-raw/loinc.R

@@ -31,8 +31,8 @@
 
 # Steps to reproduce:
 # 1. Create a fake account at https://loinc.org (sad you have to create one...)
-# 2. Download the CSV from https://loinc.org/download/loinc-complete/ (Loinc_2.67_Text_2.67.zip)
-# 3. Read Loinc.csv that's in zip folder LoincTable
+# 2. Download the CSV from https://loinc.org/download/loinc-complete/ 
+# 3. Read file LoincTable/Loinc.csv
 loinc_df <- read.csv("data-raw/Loinc.csv",
   row.names = NULL,
   stringsAsFactors = FALSE
@@ -42,31 +42,62 @@ loinc_df <- read.csv("data-raw/Loinc.csv",
 library(dplyr)
 library(cleaner)
 library(AMR)
-loinc_df %>% freq(CLASS) # to find the drugs
-loinc_df <- loinc_df %>% filter(CLASS == "DRUG/TOX")
-ab_names <- antibiotics %>%
-  pull(name) %>%
-  paste0(collapse = "|") %>%
-  paste0("(", ., ")")
+# to find the drugs:
+loinc_df %>%
+  filter(COMPONENT %like% "ampicillin|fluconazol|meropenem") %>%
+  count(CLASS, sort = TRUE)
+loinc_df <- loinc_df %>%
+  filter(CLASS %in% c("DRUG/TOX", "ABXBACT")) %>% 
+  mutate(name = generalise_antibiotic_name(COMPONENT), .before = 1)
 
+# antibiotics
 antibiotics$loinc <- as.list(rep(NA_character_, nrow(antibiotics)))
 for (i in seq_len(nrow(antibiotics))) {
   message(i)
   loinc_ab <- loinc_df %>%
-    filter(COMPONENT %like% paste0("^", antibiotics$name[i])) %>%
+    filter(name %like% paste0("^", generalise_antibiotic_name(antibiotics$name[i]))) %>%
     pull(LOINC_NUM)
   if (length(loinc_ab) > 0) {
     antibiotics$loinc[i] <- list(loinc_ab)
   }
 }
+
+# antivirals
+antivirals$loinc <- as.list(rep(NA_character_, nrow(antivirals)))
+for (i in seq_len(nrow(antivirals))) {
+  message(i)
+  loinc_ab <- loinc_df %>%
+    filter(name %like% paste0("^", generalise_antibiotic_name(antivirals$name[i]))) %>%
+    pull(LOINC_NUM)
+  if (length(loinc_ab) > 0) {
+    antivirals$loinc[i] <- list(loinc_ab)
+  }
+}
+
 # sort and fix for empty values
 for (i in 1:nrow(antibiotics)) {
-  loinc <- as.character(sort(unique(tolower(antibiotics[i, "loinc"][[1]]))))
-  antibiotics[i, "loinc"][[1]] <- ifelse(length(loinc[!loinc == ""]) == 0, list(""), list(loinc))
+  loinc <- as.character(sort(unique(tolower(antibiotics[i, "loinc", drop = TRUE][[1]]))))
+  loinc <- loinc[loinc != ""]
+  antibiotics[i, "loinc"][[1]] <- ifelse(length(loinc) == 0, list(""), list(loinc))
 }
+for (i in 1:nrow(antivirals)) {
+  loinc <- as.character(sort(unique(tolower(antivirals[i, "loinc", drop = TRUE][[1]]))))
+  loinc <- loinc[loinc != ""]
+  antivirals[i, "loinc"][[1]] <- ifelse(length(loinc) == 0, list(""), list(loinc))
+}
+
+antibiotics <- dataset_UTF8_to_ASCII(as.data.frame(antibiotics, stringsAsFactors = FALSE))
+antibiotics <- dplyr::arrange(antibiotics, name)
+
+antivirals <- dataset_UTF8_to_ASCII(as.data.frame(antivirals, stringsAsFactors = FALSE))
+antivirals <- dplyr::arrange(antivirals, name)
 
 # remember to update R/aa_globals.R for the documentation
 
 dim(antibiotics) # for R/data.R
-usethis::use_data(antibiotics, overwrite = TRUE)
+usethis::use_data(antibiotics, internal = FALSE, overwrite = TRUE, compress = "xz", version = 2)
 rm(antibiotics)
+
+dim(antivirals) # for R/data.R
+usethis::use_data(antivirals, internal = FALSE, overwrite = TRUE, compress = "xz", version = 2)
+rm(antivirals)

data-raw/microorganisms.groups.md5

@@ -1 +1 @@
-139101675d9192fa112aa120b3da97e9
+c296aff21039582a1c2d3c092ccf848c

data-raw/microorganisms.groups.txt

@@ -83,6 +83,14 @@
 "B_CTRBC_AMLN-C"	"B_CTRBC_AMLN"	"Citrobacter amalonaticus complex"	"Citrobacter amalonaticus"
 "B_CTRBC_AMLN-C"	"B_CTRBC_FRMR"	"Citrobacter amalonaticus complex"	"Citrobacter farmeri"
 "B_CTRBC_AMLN-C"	"B_CTRBC_SDLK"	"Citrobacter amalonaticus complex"	"Citrobacter sedlakii"
+"B_CTRBC_FRND-C"	"B_CTRBC_BRAK"	"Citrobacter freundii complex"	"Citrobacter braakii"
+"B_CTRBC_FRND-C"	"B_CTRBC_FRND"	"Citrobacter freundii complex"	"Citrobacter freundii"
+"B_CTRBC_FRND-C"	"B_CTRBC_GLLN"	"Citrobacter freundii complex"	"Citrobacter gillenii"
+"B_CTRBC_FRND-C"	"B_CTRBC_MRLN"	"Citrobacter freundii complex"	"Citrobacter murliniae"
+"B_CTRBC_FRND-C"	"B_CTRBC_PRTC"	"Citrobacter freundii complex"	"Citrobacter portucalensis"
+"B_CTRBC_FRND-C"	"B_CTRBC_SDLK"	"Citrobacter freundii complex"	"Citrobacter sedlakii"
+"B_CTRBC_FRND-C"	"B_CTRBC_WRKM"	"Citrobacter freundii complex"	"Citrobacter werkmanii"
+"B_CTRBC_FRND-C"	"B_CTRBC_YONG"	"Citrobacter freundii complex"	"Citrobacter youngae"
 "B_STPHY_CONS"	"B_STPHY_ARGN"	"Coagulase-negative Staphylococcus (CoNS)"	"Staphylococcus argensis"
 "B_STPHY_CONS"	"B_STPHY_ARLT"	"Coagulase-negative Staphylococcus (CoNS)"	"Staphylococcus arlettae"
 "B_STPHY_CONS"	"B_STPHY_ARCL"	"Coagulase-negative Staphylococcus (CoNS)"	"Staphylococcus auricularis"
@@ -506,3 +514,9 @@
 "B_STRPT_VIRI"	"B_STRPT_SUIS"	"Viridans Group Streptococcus (VGS)"	"Streptococcus suis"
 "B_STRPT_VIRI"	"B_STRPT_UBRS"	"Viridans Group Streptococcus (VGS)"	"Streptococcus uberis"
 "B_STRPT_VIRI"	"B_STRPT_VSTB"	"Viridans Group Streptococcus (VGS)"	"Streptococcus vestibularis"
+"B_YERSN_PSDT-C"	"B_YERSN_PSTS"	"Yersinia pseudotuberculosis complex"	"Yersinia pestis"
+"B_YERSN_PSDT-C"	"B_YERSN_PSDT"	"Yersinia pseudotuberculosis complex"	"Yersinia pseudotuberculosis"
+"B_YERSN_PSDT-C"	"B_YERSN_PSDT_PSTS"	"Yersinia pseudotuberculosis complex"	"Yersinia pseudotuberculosis pestis"
+"B_YERSN_PSDT-C"	"B_YERSN_PSDT_PSDT"	"Yersinia pseudotuberculosis complex"	"Yersinia pseudotuberculosis pseudotuberculosis"
+"B_YERSN_PSDT-C"	"B_YERSN_SMLS"	"Yersinia pseudotuberculosis complex"	"Yersinia similis"
+"B_YERSN_PSDT-C"	"B_YERSN_WTRS"	"Yersinia pseudotuberculosis complex"	"Yersinia wautersii"

data-raw/microorganisms.md5

@@ -1 +1 @@
-fb5a6892877b6ac86040e1f0508486c5
+a79ae177d6b45404514789f45ba0f963

data-raw/microorganisms.txt

@@ -11206,6 +11206,7 @@
 "B_CTRBC_ERPS"	"Citrobacter europaeus"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Enterobacteriaceae"	"Citrobacter"	"europaeus"	""	"species"	"Ribeiro et al., 2017"	"facultative anaerobe"	"LPSN"	"795042"	"515376"		"9554238"	"11150190"		1.5	""
 "B_CTRBC_FRMR"	"Citrobacter farmeri"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Enterobacteriaceae"	"Citrobacter"	"farmeri"	""	"species"	"Brenner et al., 1993"	"aerobe"	"LPSN"	"774746"	"515376"		"3221799"	"11150190"		1	"1089701000112106,114263005"
 "B_CTRBC_FRND"	"Citrobacter freundii"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Enterobacteriaceae"	"Citrobacter"	"freundii"	""	"species"	"Werkman et al., 1932"	"aerobe"	"LPSN"	"774747"	"515376"		"10732598"	"11150190"		1	"1089901000112108,6265002,721909006,715206000"
+"B_CTRBC_FRND-C"	"Citrobacter freundii complex"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Enterobacteriaceae"	"Citrobacter"	"freundii complex"	""	"species group"		"aerobe"	"manually added"		"515376"			"11150190"		1	""
 "B_CTRBC_GLLN"	"Citrobacter gillenii"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Enterobacteriaceae"	"Citrobacter"	"gillenii"	""	"species"	"Brenner et al., 2000"	"aerobe"	"LPSN"	"774750"	"515376"		"3221794"	"11150190"		1.5	"416990006"
 "B_CTRBC_KOSR"	"Citrobacter koseri"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Enterobacteriaceae"	"Citrobacter"	"koseri"	""	"species"	"Frederiksen, 1970"	"aerobe"	"LPSN"	"774752"	"515376"		"3221790"	"11150190"		1	"1090401000112109,114264004"
 "B_CTRBC_MLNT"	"Citrobacter malonatica"	"synonym"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Enterobacteriaceae"	"Citrobacter"	"malonatica"	""	"species"	"Young et al., 1971"	"aerobe"	"GBIF"				"5427569"	"11150190"	"3221790"	1	""
@@ -38966,6 +38967,7 @@
 "B_RPHDP_SBRC"	"Raphidiopsis subrecta"	"synonym"	"Bacteria"	"Cyanobacteria"	"Cyanobacteriia"	"Cyanobacteriales"	"Nostocaceae"	"Raphidiopsis"	"subrecta"	""	"species"	"Fremy et al."		"GBIF"				"7555557"	"3219380"	"4306613"	2	""
 "B_RPDTH"	"Rapidithrix"	"accepted"	"Bacteria"	"Bacteroidota"	"Cytophagia"	"Cytophagales"	"Flammeovirgaceae"	"Rapidithrix"	""	""	"genus"	"Srisukchayakul et al., 2007"	"aerobe"	"LPSN"	"517677"	"522"		"4903792"			2	""
 "B_RPDTH_THLN"	"Rapidithrix thailandica"	"accepted"	"Bacteria"	"Bacteroidota"	"Cytophagia"	"Cytophagales"	"Flammeovirgaceae"	"Rapidithrix"	"thailandica"	""	"species"	"Srisukchayakul et al., 2007"	"aerobe"	"LPSN"	"786823"	"517677"		"5917946"	"4903792"		2	""
+"B_MYCBC_RGM"	"Rapidly growing Mycobacterium (RGM)"	"accepted"	"Bacteria"	"Actinomycetota"	"Actinomycetes"	"Mycobacteriales"	"Mycobacteriaceae"	"Mycobacterium"	"rapidly growing"	""	"species group"		"facultative anaerobe"	"manually added"		"912"			"8084"		1	""
 "B_RPPPR"	"Rappaport"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Cardiobacteriales"	"Cardiobacteriaceae"	"Rappaport"	""	""	"genus"			"GBIF"				"10714677"	"8970"		2	""
 "B_RPPPR_ISRL"	"Rappaport israeli"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Cardiobacteriales"	"Cardiobacteriaceae"	"Rappaport"	"israeli"	""	"species"			"GBIF"				"10890221"	"10714677"		2	""
 "B_RRGLB"	"Rariglobus"	"accepted"	"Bacteria"	"Verrucomicrobiota"	"Opitutae"	"Opitutales"	"Opitutaceae"	"Rariglobus"	""	""	"genus"	"Pitt et al., 2020"		"LPSN"	"4967"	"993"		"11151485"			2	""
@@ -51989,6 +51991,7 @@
 "B_YERSN_PHLM"	"Yersinia philomiragia"	"synonym"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Yersiniaceae"	"Yersinia"	"philomiragia"	""	"species"	"Jensen et al., 1969"	"microaerophile"	"LPSN"	"783201"	"516947"	"776319"				1	""
 "B_YERSN_PRXM"	"Yersinia proxima"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Yersiniaceae"	"Yersinia"	"proxima"	""	"species"	"Le Guern et al., 2020"	"likely facultative anaerobe"	"LPSN"	"14095"	"516947"					1.5	""
 "B_YERSN_PSDT"	"Yersinia pseudotuberculosis"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Yersiniaceae"	"Yersinia"	"pseudotuberculosis"	""	"species"	"Smith et al., 1965"	"likely facultative anaerobe"	"LPSN"	"783202"	"516947"		"5427620"	"3221889"	"5427631"	1	"90530002"
+"B_YERSN_PSDT-C"	"Yersinia pseudotuberculosis complex"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Yersiniaceae"	"Yersinia"	"pseudotuberculosis complex"	""	"species group"		"likely facultative anaerobe"	"manually added"		"516947"			"3221889"		1	""
 "B_YERSN_PSDT_PSTS"	"Yersinia pseudotuberculosis pestis"	"synonym"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Yersiniaceae"	"Yersinia"	"pseudotuberculosis"	"pestis"	"subspecies"	"Bercovier et al., 1981"	"aerobe"	"LPSN"	"798529"	"783202"	"785226"				1	""
 "B_YERSN_PSDT_PSDT"	"Yersinia pseudotuberculosis pseudotuberculosis"	"synonym"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Yersiniaceae"	"Yersinia"	"pseudotuberculosis"	"pseudotuberculosis"	"subspecies"	"Bercovier et al., 1981"	"aerobe"	"LPSN"	"798530"	"783202"	"783202"				1	""
 "B_YERSN_RCHS"	"Yersinia rochesterensis"	"accepted"	"Bacteria"	"Pseudomonadota"	"Gammaproteobacteria"	"Enterobacterales"	"Yersiniaceae"	"Yersinia"	"rochesterensis"	""	"species"	"Nguyen et al., 2021"	"likely facultative anaerobe"	"LPSN"	"17336"	"516947"		"11652009"	"3221889"		1.5	""
@@ -52167,4 +52170,3 @@
 "B_ZYMPH"	"Zymophilus"	"synonym"	"Bacteria"	"Bacillota"	"Negativicutes"	"Selenomonadales"	"Selenomonadaceae"	"Zymophilus"	""	""	"genus"	"Schleifer et al., 1990"	"anaerobe"	"LPSN"	"516961"	"2042"	"516396"				2	"438883001"
 "B_ZYMPH_PCVR"	"Zymophilus paucivorans"	"synonym"	"Bacteria"	"Bacillota"	"Negativicutes"	"Selenomonadales"	"Selenomonadaceae"	"Zymophilus"	"paucivorans"	""	"species"	"Schleifer et al., 1990"	"anaerobe"	"LPSN"	"783229"	"516961"	"792213"				2	"440843008"
 "B_ZYMPH_RFFN"	"Zymophilus raffinosivorans"	"synonym"	"Bacteria"	"Bacillota"	"Negativicutes"	"Selenomonadales"	"Selenomonadaceae"	"Zymophilus"	"raffinosivorans"	""	"species"	"Schleifer et al., 1990"	"anaerobe"	"LPSN"	"783230"	"516961"	"792212"				2	"440844002"
-"B_MYCBC_RGM"	"Rapidly growing Mycobacterium (RGM)"	"accepted"	"Bacteria"	"Actinomycetota"	"Actinomycetes"	"Mycobacteriales"	"Mycobacteriaceae"	"Mycobacterium"	"rapidly growing"	""	"species group"		"facultative anaerobe"	"manually added"		"912"			"8084"		1	""

data-raw/reproduction_of_antibiotics.R

@@ -851,6 +851,8 @@ antibiotics <- dataset_UTF8_to_ASCII(as.data.frame(antibiotics, stringsAsFactors
 class(antibiotics$ab) <- c("ab", "character")
 antibiotics <- dplyr::arrange(antibiotics, name)
 
+# REFER TO data-raw/loinc.R FOR ADDING LOINC CODES
+
 # make all abbreviations and synonyms lower case, unique and alphabetically sorted ----
 for (i in 1:nrow(antibiotics)) {
   abb <- as.character(sort(unique(tolower(antibiotics[i, "abbreviations", drop = TRUE][[1]]))))
@@ -866,7 +868,6 @@ for (i in 1:nrow(antibiotics)) {
   }
 }
 
-# REFER TO data-raw/loinc.R FOR ADDING LOINC CODES
 
 usethis::use_data(antibiotics, overwrite = TRUE, version = 2, compress = "xz")
 rm(antibiotics)

data-raw/reproduction_of_antivirals.R

@@ -142,33 +142,7 @@ antivirals <- bind_cols(
 class(antivirals$av) <- c("av", "character")
 antivirals <- antivirals %>% AMR:::dataset_UTF8_to_ASCII()
 
-# add loinc, see 'data-raw/loinc.R'
-loinc_df <- read.csv("data-raw/Loinc.csv",
-  row.names = NULL,
-  stringsAsFactors = FALSE
-)
-
-loinc_df <- loinc_df %>% filter(CLASS == "DRUG/TOX")
-av_names <- antivirals %>%
-  pull(name) %>%
-  paste0(collapse = "|") %>%
-  paste0("(", ., ")")
-
-antivirals$loinc <- as.list(rep(NA_character_, nrow(antivirals)))
-for (i in seq_len(nrow(antivirals))) {
-  message(i)
-  loinc_ab <- loinc_df %>%
-    filter(COMPONENT %like% paste0("^", antivirals$name[i])) %>%
-    pull(LOINC_NUM)
-  if (length(loinc_ab) > 0) {
-    antivirals$loinc[i] <- list(loinc_ab)
-  }
-}
-# sort and fix for empty values
-for (i in 1:nrow(antivirals)) {
-  loinc <- as.character(sort(unique(tolower(antivirals[i, "loinc", drop = TRUE][[1]]))))
-  antivirals[i, "loinc"][[1]] <- ifelse(length(loinc[!loinc == ""]) == 0, list(""), list(loinc))
-}
+# ! add loinc, run 'data-raw/loinc.R' !
 
 # de-duplicate synonyms
 for (i in 1:nrow(antivirals)) {

data-raw/reproduction_of_clinical_breakpoints.R

@@ -192,7 +192,7 @@ devtools::load_all()
 
 # BREAKPOINTS ----
 
-# now that we have the right MO codes, get the breakpoints and convert them
+# now that we have the correct MO codes, get the breakpoints and convert them
 
 whonet_breakpoints %>% 
   count(GUIDELINES, BREAKPOINT_TYPE) %>% 
@@ -213,7 +213,7 @@ unknown <- breakpoints %>%
 breakpoints %>% 
   filter(code %in% unknown) %>% 
   count(GUIDELINES, YEAR, ORGANISM_CODE, BREAKPOINT_TYPE, sort = TRUE)
-# these codes are currently (2023-07-08): clu, kma. No clue, so remove them:
+# these codes are currently (2023-07-08): clu, kma. No clue (are not in MO list of WHONET), so remove them:
 breakpoints <- breakpoints %>% 
   filter(!is.na(mo))
 
@@ -284,6 +284,9 @@ breakpoints_new <- breakpoints_new %>%
 breakpoints_new[which(breakpoints_new$method == "DISK"), "breakpoint_S"] <- as.double(as.disk(breakpoints_new[which(breakpoints_new$method == "DISK"), "breakpoint_S", drop = TRUE]))
 breakpoints_new[which(breakpoints_new$method == "DISK"), "breakpoint_R"] <- as.double(as.disk(breakpoints_new[which(breakpoints_new$method == "DISK"), "breakpoint_R", drop = TRUE]))
 
+
+# FIXES FOR WHONET ERRORS ----
+
 # WHONET has no >1024 but instead uses 1025, 513, etc, so as.mic() cannot be used to clean.
 # instead, clean based on MIC factor levels
 m <- unique(as.double(as.mic(levels(as.mic(1)))))
@@ -315,7 +318,9 @@ clinical_breakpoints <- clinical_breakpoints %>% filter(mo != as.mo("Achromobact
 clinical_breakpoints <- clinical_breakpoints %>% filter(!(mo == as.mo("Streptococcus viridans") & ab == "GEN"))
 # Nitrofurantoin in Staph (EUCAST) only applies to S. saprophyticus, while WHONET has the DISK correct but the MIC on genus level
 clinical_breakpoints$mo[clinical_breakpoints$mo == "B_STPHY" & clinical_breakpoints$ab == "NIT" & clinical_breakpoints$guideline %like% "EUCAST"] <- as.mo("B_STPHY_SPRP")
-# determine rank again
+# WHONET sets the 2023 breakpoints for SAM to MIC of 16/32 for Enterobacterales, should be MIC 8/32 like AMC (see issue #123 on github.com/msberends/AMR)
+clinical_breakpoints$breakpoint_S[clinical_breakpoints$mo == "B_[ORD]_ENTRBCTR" & clinical_breakpoints$ab == "SAM" & clinical_breakpoints$guideline %like% "CLSI 2023" & clinical_breakpoints$method == "MIC"] <- 8
+# determine rank again now that some changes were made on taxonomic level (genus -> species)
 clinical_breakpoints <- clinical_breakpoints %>% 
   mutate(rank_index = case_when(
     is.na(mo_rank(mo, keep_synonyms = TRUE)) ~ 6, # for UNKNOWN, B_GRAMN, B_ANAER, B_ANAER-NEG, etc.
@@ -328,7 +333,6 @@ clinical_breakpoints <- clinical_breakpoints %>%
     TRUE ~ 6
   ))
 
-
 # WHONET adds one log2 level to the R breakpoint for their software, e.g. in AMC in Enterobacterales:
 # EUCAST 2022 guideline: S <= 8 and R > 8
 #           WHONET file: S <= 8 and R >= 16
@@ -349,6 +353,9 @@ breakpoints_new <- breakpoints_new %>%
 # fix missing R breakpoint where there is an S breakpoint
 breakpoints_new[which(is.na(breakpoints_new$breakpoint_R)), "breakpoint_R"] <- breakpoints_new[which(is.na(breakpoints_new$breakpoint_R)), "breakpoint_S"]
 
+
+# CHECKS AND SAVE TO PACKAGE ----
+
 # check again
 breakpoints_new %>% filter(guideline == "EUCAST 2023", ab == "AMC", mo == "B_[ORD]_ENTRBCTR", method == "MIC")
 # compare with current version
@@ -361,8 +368,6 @@ breakpoints_new %>% filter(mo == "B_STRPT_PNMN", ab == "AMP", guideline == "EUCA
 dim(breakpoints_new)
 dim(clinical_breakpoints)
 
-# SAVE TO PACKAGE ----
-
 clinical_breakpoints <- breakpoints_new
 clinical_breakpoints <- clinical_breakpoints %>% dataset_UTF8_to_ASCII()
 usethis::use_data(clinical_breakpoints, overwrite = TRUE, compress = "xz", version = 2)

data-raw/reproduction_of_microorganisms.groups.R

@@ -38,6 +38,13 @@ devtools::load_all()
 # Install the WHONET software on Windows (http://www.whonet.org/software.html),
 # and copy the folder C:\WHONET\Resources to the data-raw/WHONET/ folder
 
+
+# BACTERIAL COMPLEXES
+# find all bacterial complex in the NCBI Taxonomy Browser here:
+# https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Undef&id=2&lvl=6&lin=f&keep=1&srchmode=1&unlock
+# and search the page for 'complex', then follow the link and add the missing ones in this R file
+
+
 # READ DATA ----
 
 whonet_organisms <- read_tsv("data-raw/WHONET/Resources/Organisms.txt", na = c("", "NA", "-"), show_col_types = FALSE) %>%
@@ -131,6 +138,16 @@ microorganisms.groups <- whonet_organisms %>%
   bind_rows(tibble(mo_group = as.mo("HACEK"), mo = as.mo("Eikenella corrodens", keep_synonyms = TRUE))) %>%
   bind_rows(tibble(mo_group = as.mo("HACEK"), mo = microorganisms %>% filter(genus == "Kingella") %>% pull(mo))) %>%
   bind_rows(tibble(mo_group = as.mo("HACEK"), mo = as.mo("Actinobacillus actinomycetemcomitans", keep_synonyms = TRUE))) %>%
+  # Citrobacter freundii complex in the NCBI Taxonomy Browser:
+  # https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1344959
+  filter(mo_group != "B_CTRBC_FRND-C") %>% 
+  bind_rows(tibble(mo_group = as.mo("B_CTRBC_FRND-C"),
+                   mo = paste("Citrobacter", c("freundii", "braakii", "gillenii", "murliniae", "portucalensis", "sedlakii", "werkmanii", "youngae")) %>% as.mo(keep_synonyms = TRUE))) %>% 
+  # Yersinia pseudotuberculosis complex in the NCBI Taxonomy Browser:
+  # https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=1649845
+  filter(mo_group != "B_YERSN_PSDT-C") %>% 
+  bind_rows(tibble(mo_group = as.mo("B_YERSN_PSDT-C"),
+                   mo = paste("Yersinia", c("pseudotuberculosis", "pestis", "similis", "wautersii")) %>% as.mo(keep_synonyms = TRUE))) %>% 
   # RGM are Rapidly-grwoing Mycobacteria, see https://pubmed.ncbi.nlm.nih.gov/28084211/
   filter(mo_group != "B_MYCBC_RGM") %>% 
   bind_rows(tibble(mo_group = as.mo("B_MYCBC_RGM"),

inst/tinytest/test-ab_property.R

@@ -63,7 +63,7 @@ expect_stdout(print(ab_name("amox", language = NULL)))
 expect_equal(ab_name("21066-6", language = NULL), "Ampicillin")
 expect_equal(
   ab_loinc("ampicillin"),
-  c("21066-6", "3355-5", "33562-0", "33919-2", "43883-8", "43884-6", "87604-5")
+  c("101477-8", "101478-6", "18864-9", "18865-6", "20374-5", "21066-6", "23618-2", "27-3", "28-1", "29-9", "30-7", "31-5", "32-3", "33-1", "3355-5", "33562-0", "33919-2", "34-9", "43883-8", "43884-6", "6979-9", "6980-7", "87604-5")
 )
 
 expect_true(ab_url("AMX") %like% "whocc.no")

inst/tinytest/test-antibiogram.R

@@ -78,19 +78,19 @@ ab6 <- antibiogram(example_isolates,
                    syndromic_group = "ward")
 
 # with a custom language, though this will be determined automatically
-# (i.e., this table will be in Spanish on Spanish systems)
+# (i.e., this table will be in Dutch on Dutch systems)
 ex1 <- example_isolates[which(mo_genus() == "Escherichia"), ]
 ab7 <- antibiogram(ex1,
                    antibiotics = aminoglycosides(),
                    ab_transform = "name",
                    syndromic_group = ifelse(ex1$ward == "ICU",
-                                            "UCI", "No UCI"),
-                   language = "es")
+                                            "IC", "Geen IC"),
+                   language = "nl")
 
 expect_inherits(ab6, "antibiogram")
 expect_inherits(ab7, "antibiogram")
 expect_equal(colnames(ab6), c("Syndromic Group", "Pathogen (N min-max)", "AMK", "GEN", "IPM", "KAN", "MEM", "TOB"))
-expect_equal(colnames(ab7), c("Grupo sindrómico", "Patógeno (N min-max)", "Amikacina", "Gentamicina", "Tobramicina"))
+expect_equal(colnames(ab7), c("Syndroomgroep", "Pathogeen (N min-max)", "Amikacine", "Gentamicine", "Tobramycine"))
 
 # Weighted-incidence syndromic combination antibiogram (WISCA) ---------
 

inst/tinytest/test-av_property.R

@@ -57,7 +57,7 @@ expect_stdout(print(av_name("acic", language = NULL)))
 expect_equal(av_name("29113-8", language = NULL), "Abacavir")
 expect_equal(
   av_loinc("Abacavir"),
-  c("29113-8", "78772-1", "78773-9", "79134-3", "80118-3")
+  c("29113-8", "30273-7", "30287-7", "30303-2", "78772-1", "78773-9", "79134-3", "80118-3")
 )
 
 expect_true(av_url("ACI") %like% "whocc.no")

inst/tinytest/test-first_isolate.R

@@ -42,9 +42,22 @@ expect_equal(
 )
 expect_equal(
   sum(first_isolate(x = example_isolates, method = "phenotype-based", info = TRUE), na.rm = TRUE),
-  1379
+  1373
 )
 
+# for phenotype determination
+expect_equal(AMR:::duplicated_antibiogram("SSSS", points_threshold = 2, ignore_I = TRUE, type = "points"),
+             FALSE)
+expect_equal(AMR:::duplicated_antibiogram(c("RRR", "SSS"),
+                                          points_threshold = 2, ignore_I = TRUE, type = "points"),
+             c(FALSE, FALSE))
+expect_equal(AMR:::duplicated_antibiogram(c("RRR", "RRR", "SSS"),
+                                          points_threshold = 2, ignore_I = TRUE, type = "points"),
+             c(FALSE, TRUE, FALSE))
+expect_equal(AMR:::duplicated_antibiogram(c("RRR", "RSS", "SSS", "RSS", "RRR", "RRR", "SSS", "RSS", "RSR", "RRR"),
+                                          points_threshold = 2, ignore_I = TRUE, type = "points"),
+             c(FALSE, FALSE, FALSE, TRUE, TRUE, TRUE, TRUE, TRUE, FALSE, TRUE))
+
 # Phenotype-based, using key antimicrobials
 expect_equal(
   sum(first_isolate(
@@ -53,7 +66,7 @@ expect_equal(
     type = "keyantimicrobials",
     antifungal = NULL, info = TRUE
   ), na.rm = TRUE),
-  1395
+  1376
 )
 expect_equal(
   sum(first_isolate(
@@ -62,7 +75,7 @@ expect_equal(
     type = "keyantimicrobials",
     antifungal = NULL, info = TRUE, ignore_I = FALSE
   ), na.rm = TRUE),
-  1418
+  1396
 )
 
 
@@ -93,7 +106,7 @@ expect_true(
     col_specimen = "specimen",
     filter_specimen = "Urine",
     info = TRUE
-  ), na.rm = TRUE) < 1501
+  ), na.rm = TRUE) < 1400
 )
 # same, but now exclude ICU
 expect_true(
@@ -107,7 +120,7 @@ expect_true(
     col_icu = x$ward == "ICU",
     icu_exclude = TRUE,
     info = TRUE
-  ), na.rm = TRUE) < 1501
+  ), na.rm = TRUE) < 1000
 )
 
 # "No isolates found"
@@ -193,7 +206,7 @@ expect_equal(
     ),
     na.rm = TRUE
   ),
-  1382
+  1376
 )
 
 # unknown MOs
@@ -201,23 +214,23 @@ test_unknown <- example_isolates
 test_unknown$mo <- ifelse(test_unknown$mo == "B_ESCHR_COLI", "UNKNOWN", test_unknown$mo)
 expect_equal(
   sum(first_isolate(test_unknown, include_unknown = FALSE)),
-  1108
+  1106
 )
 expect_equal(
   sum(first_isolate(test_unknown, include_unknown = TRUE)),
-  1591
+  1589
 )
 
 test_unknown$mo <- ifelse(test_unknown$mo == "UNKNOWN", NA, test_unknown$mo)
 expect_equal(
   sum(first_isolate(test_unknown)),
-  1108
+  1106
 )
 
 # empty sir results
 expect_equal(
   sum(first_isolate(example_isolates, include_untested_sir = FALSE)),
-  1366
+  1360
 )
 
 # shortcuts

inst/tinytest/test-zzz.R

@@ -61,6 +61,10 @@ call_functions <- c(
   "freq.default" = "cleaner",
   # cli
   "symbol" = "cli",
+  "ansi_has_hyperlink_support" = "cli",
+  # rstudioapi (RStudio)
+  "isAvailable" = "rstudioapi",
+  "versionInfo" = "rstudioapi",
   # readxl
   "read_excel" = "readxl",
   # ggplot2
@@ -120,18 +124,19 @@ for (i in seq_len(length(import_functions))) {
     also_load = FALSE,
     min_version = if (pkg == "dplyr") "1.0.0" else NULL
   )) {
-    tst <- !is.null(AMR:::import_fn(name = fn, pkg = pkg, error_on_fail = FALSE))
-    expect_true(tst,
-      info = ifelse(tst,
-        "All external function references exist.",
-        paste0("Function ", pkg, "::", fn, "() does not exist anymore")
-      )
+    expect_true(!is.null(AMR:::import_fn(name = fn, pkg = pkg, error_on_fail = FALSE)),
+      info = paste0("does not exist (anymore): function `", pkg, "::", fn, "()`")
     )
+  } else {
+    warning("Package '", pkg, "' does not exist anymore")
   }
 }
 
 if (AMR:::pkg_is_available("cli")) {
   expect_true(!is.null(cli::symbol$info))
-  expect_true(!is.null(cli::symbol$bullet))
+}
+if (AMR:::pkg_is_available("cli")) {
+}
+if (AMR:::pkg_is_available("cli")) {
   expect_true(!is.null(cli::symbol$ellipsis))
 }

man/AMR.Rd

@@ -8,7 +8,7 @@
 \source{
 To cite AMR in publications use:
 
-Berends MS, Luz CF, Friedrich AW, Sinha BNM, Albers CJ, Glasner C (2022). "AMR: An R Package for Working with Antimicrobial Resistance Data." \emph{Journal of Statistical Software}, \emph{104}(3), 1-31. \doi{10.18637/jss.v104.i03}.
+Berends MS, Luz CF, Friedrich AW, Sinha BNM, Albers CJ, Glasner C (2022). "AMR: An R Package for Working with Antimicrobial Resistance Data." \emph{Journal of Statistical Software}, \emph{104}(3), 1-31. \doi{10.18637/jss.v104.i03}
 
 A BibTeX entry for LaTeX users is:
 
@@ -30,9 +30,9 @@ Welcome to the \code{AMR} package.
 
 The \code{AMR} package is a \href{https://msberends.github.io/AMR/#copyright}{free and open-source} R package with \href{https://en.wikipedia.org/wiki/Dependency_hell}{zero dependencies} to simplify the analysis and prediction of Antimicrobial Resistance (AMR) and to work with microbial and antimicrobial data and properties, by using evidence-based methods. \strong{Our aim is to provide a standard} for clean and reproducible AMR data analysis, that can therefore empower epidemiological analyses to continuously enable surveillance and treatment evaluation in any setting. \href{https://msberends.github.io/AMR/authors.html}{Many different researchers} from around the globe are continually helping us to make this a successful and durable project!
 
-This work was published in the Journal of Statistical Software (Volume 104(3); \doi{jss.v104.i03}) and formed the basis of two PhD theses (\doi{10.33612/diss.177417131} and \doi{10.33612/diss.192486375}).
+This work was published in the Journal of Statistical Software (Volume 104(3); \doi{10.18637/jss.v104.i03}) and formed the basis of two PhD theses (\doi{10.33612/diss.177417131} and \doi{10.33612/diss.192486375}).
 
-After installing this package, R knows \href{https://msberends.github.io/AMR/reference/microorganisms.html}{\strong{~52 000 microorganisms}} (updated december 2022) and all \href{https://msberends.github.io/AMR/reference/antibiotics.html}{\strong{~600 antibiotic, antimycotic and antiviral drugs}} by name and code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC and SNOMED CT), and knows all about valid SIR and MIC values. The integral clinical breakpoint guidelines from CLSI and EUCAST are included, even with epidemiological cut-off (ECOFF) values. It supports and can read any data format, including WHONET data. This package works on Windows, macOS and Linux with all versions of R since R-3.0 (April 2013). \strong{It was designed to work in any setting, including those with very limited resources}. It was created for both routine data analysis and academic research at the Faculty of Medical Sciences of the \href{https://www.rug.nl}{University of Groningen}, in collaboration with non-profit organisations \href{https://www.certe.nl}{Certe Medical Diagnostics and Advice Foundation} and \href{https://www.umcg.nl}{University Medical Center Groningen}.
+After installing this package, R knows \href{https://msberends.github.io/AMR/reference/microorganisms.html}{\strong{~52 000 microorganisms}} (updated December 2022) and all \href{https://msberends.github.io/AMR/reference/antibiotics.html}{\strong{~600 antibiotic, antimycotic and antiviral drugs}} by name and code (including ATC, EARS-Net, ASIARS-Net, PubChem, LOINC and SNOMED CT), and knows all about valid SIR and MIC values. The integral clinical breakpoint guidelines from CLSI and EUCAST are included, even with epidemiological cut-off (ECOFF) values. It supports and can read any data format, including WHONET data. This package works on Windows, macOS and Linux with all versions of R since R-3.0 (April 2013). \strong{It was designed to work in any setting, including those with very limited resources}. It was created for both routine data analysis and academic research at the Faculty of Medical Sciences of the public \href{https://www.rug.nl}{University of Groningen}, in collaboration with non-profit organisations \href{https://www.certe.nl}{Certe Medical Diagnostics and Advice Foundation} and \href{https://www.umcg.nl}{University Medical Center Groningen}.
 
 The \code{AMR} package is available in English, Chinese, Czech, Danish, Dutch, Finnish, French, German, Greek, Italian, Japanese, Norwegian, Polish, Portuguese, Romanian, Russian, Spanish, Swedish, Turkish, and Ukrainian. Antimicrobial drug (group) names and colloquial microorganism names are provided in these languages.
 }

man/antibiotics.Rd

@@ -8,9 +8,9 @@
 \format{
 \subsection{For the \link{antibiotics} data set: a \link[tibble:tibble]{tibble} with 483 observations and 14 variables:}{
 \itemize{
-\item \code{ab}\cr Antibiotic ID as used in this package (such as \code{AMC}), using the official EARS-Net (European Antimicrobial Resistance Surveillance Network) codes where available
-\item \code{cid}\cr Compound ID as found in PubChem
-\item \code{name}\cr Official name as used by WHONET/EARS-Net or the WHO
+\item \code{ab}\cr Antibiotic ID as used in this package (such as \code{AMC}), using the official EARS-Net (European Antimicrobial Resistance Surveillance Network) codes where available. \emph{This is a unique identifier.}
+\item \code{cid}\cr Compound ID as found in PubChem. \emph{This is a unique identifier.}
+\item \code{name}\cr Official name as used by WHONET/EARS-Net or the WHO. \emph{This is a unique identifier.}
 \item \code{group}\cr A short and concise group name, based on WHONET and WHOCC definitions
 \item \code{atc}\cr ATC codes (Anatomical Therapeutic Chemical) as defined by the WHOCC, like \code{J01CR02}
 \item \code{atc_group1}\cr Official pharmacological subgroup (3rd level ATC code) as defined by the WHOCC, like \code{"Macrolides, lincosamides and streptogramins"}
@@ -21,23 +21,23 @@
 \item \code{oral_units}\cr Units of \code{oral_ddd}
 \item \code{iv_ddd}\cr Defined Daily Dose (DDD), parenteral (intravenous) treatment, currently available for 146 drugs
 \item \code{iv_units}\cr Units of \code{iv_ddd}
-\item \code{loinc}\cr All LOINC codes (Logical Observation Identifiers Names and Codes) associated with the name of the antimicrobial drug. Use \code{\link[=ab_loinc]{ab_loinc()}} to retrieve them quickly, see \code{\link[=ab_property]{ab_property()}}.
+\item \code{loinc}\cr All codes associated with the name of the antimicrobial drug from Logical Observation Identifiers Names and Codes (LOINC), Version 2.76 (18 September, 2023). Use \code{\link[=ab_loinc]{ab_loinc()}} to retrieve them quickly, see \code{\link[=ab_property]{ab_property()}}.
 }
 }
 
 \subsection{For the \link{antivirals} data set: a \link[tibble:tibble]{tibble} with 120 observations and 11 variables:}{
 \itemize{
-\item \code{av}\cr Antibiotic ID as used in this package (such as \code{AMC}), using the official EARS-Net (European Antimicrobial Resistance Surveillance Network) codes where available
-\item \code{name}\cr Official name as used by WHONET/EARS-Net or the WHO
+\item \code{av}\cr Antiviral ID as used in this package (such as \code{ACI}), using the official EARS-Net (European Antimicrobial Resistance Surveillance Network) codes where available. \emph{This is a unique identifier.} Combinations are codes that contain a \code{+} to indicate this, such as \code{ATA+COBI} for atazanavir/cobicistat.
+\item \code{name}\cr Official name as used by WHONET/EARS-Net or the WHO. \emph{This is a unique identifier.}
 \item \code{atc}\cr ATC codes (Anatomical Therapeutic Chemical) as defined by the WHOCC
-\item \code{cid}\cr Compound ID as found in PubChem
+\item \code{cid}\cr Compound ID as found in PubChem. \emph{This is a unique identifier.}
 \item \code{atc_group}\cr Official pharmacological subgroup (3rd level ATC code) as defined by the WHOCC
 \item \code{synonyms}\cr Synonyms (often trade names) of a drug, as found in PubChem based on their compound ID
 \item \code{oral_ddd}\cr Defined Daily Dose (DDD), oral treatment
 \item \code{oral_units}\cr Units of \code{oral_ddd}
 \item \code{iv_ddd}\cr Defined Daily Dose (DDD), parenteral treatment
 \item \code{iv_units}\cr Units of \code{iv_ddd}
-\item \code{loinc}\cr All LOINC codes (Logical Observation Identifiers Names and Codes) associated with the name of the antimicrobial drug.
+\item \code{loinc}\cr All codes associated with the name of the antiviral drug from Logical Observation Identifiers Names and Codes (LOINC), Version 2.76 (18 September, 2023). Use \code{\link[=av_loinc]{av_loinc()}} to retrieve them quickly, see \code{\link[=av_property]{av_property()}}.
 }
 }
 
@@ -46,7 +46,7 @@ An object of class \code{tbl_df} (inherits from \code{tbl}, \code{data.frame}) w
 \source{
 \itemize{
 \item World Health Organization (WHO) Collaborating Centre for Drug Statistics Methodology (WHOCC): \url{https://www.whocc.no/atc_ddd_index/}
-\item Logical Observation Identifiers Names and Codes (LOINC), Version 2.73 (8 August, 2022). Accessed from \url{https://loinc.org} on October 30th, 2022.
+\item Logical Observation Identifiers Names and Codes (LOINC), Version 2.76 (18 September, 2023). Accessed from \url{https://loinc.org} on October 19th, 2023.
 \item European Commission Public Health PHARMACEUTICALS - COMMUNITY REGISTER: \url{https://ec.europa.eu/health/documents/community-register/html/reg_hum_atc.htm}
 }
 }

man/as.mic.Rd

@@ -114,9 +114,6 @@ if (require("ggplot2")) {
 if (require("ggplot2")) {
   autoplot(mic_data, mo = "E. coli", ab = "cipro", language = "nl") # Dutch
 }
-if (require("ggplot2")) {
-  autoplot(mic_data, mo = "E. coli", ab = "cipro", language = "uk") # Ukrainian
-}
 }
 \seealso{
 \code{\link[=as.sir]{as.sir()}}

man/as.mo.Rd

@@ -127,7 +127,7 @@ The coercion rules consider the prevalence of microorganisms in humans, which is
 \item Parte, AC \emph{et al.} (2020). \strong{List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ.} International Journal of Systematic and Evolutionary Microbiology, 70, 5607-5612; \doi{10.1099/ijsem.0.004332}. Accessed from \url{https://lpsn.dsmz.de} on December 11th, 2022.
 \item GBIF Secretariat (2022). GBIF Backbone Taxonomy. Checklist dataset \doi{10.15468/39omei}. Accessed from \url{https://www.gbif.org} on December 11th, 2022.
 \item Reimer, LC \emph{et al.} (2022). \strong{\emph{BacDive} in 2022: the knowledge base for standardized bacterial and archaeal data.} Nucleic Acids Res., 50(D1):D741-D74; \doi{10.1093/nar/gkab961}. Accessed from \url{https://bacdive.dsmz.de} on May 12th, 2023.
-\item Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microoganism', OID 2.16.840.1.114222.4.11.1009 (v12). URL: \url{https://phinvads.cdc.gov}
+\item Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microorganism', OID 2.16.840.1.114222.4.11.1009 (v12). URL: \url{https://phinvads.cdc.gov}
 \item Bartlett A \emph{et al.} (2022). \strong{A comprehensive list of bacterial pathogens infecting humans} \emph{Microbiology} 168:001269; \doi{10.1099/mic.0.001269}
 }
 }

man/clinical_breakpoints.Rd

@@ -42,7 +42,7 @@ Clinical breakpoints in this package were validated through and imported from \h
 
 \subsection{Response from CLSI and EUCAST}{
 
-The CEO of CLSI and the chairman of EUCAST have endorsed the work and public use of this \code{AMR} package in June 2023, when future development of distributing clinical breakpoints was discussed in a meeting between CLSI, EUCAST, the WHO, and developers of WHONET and the \code{AMR} package.
+The CEO of CLSI and the chairman of EUCAST have endorsed the work and public use of this \code{AMR} package (and consequently the use of their breakpoints) in June 2023, when future development of distributing clinical breakpoints was discussed in a meeting between CLSI, EUCAST, the WHO, and developers of WHONET and the \code{AMR} package.
 }
 
 \subsection{Download}{

man/microorganisms.Rd

@@ -3,18 +3,18 @@
 \docType{data}
 \name{microorganisms}
 \alias{microorganisms}
-\title{Data Set with 52 169 Microorganisms}
+\title{Data Set with 52 171 Microorganisms}
 \format{
-A \link[tibble:tibble]{tibble} with 52 169 observations and 23 variables:
+A \link[tibble:tibble]{tibble} with 52 171 observations and 23 variables:
 \itemize{
-\item \code{mo}\cr ID of microorganism as used by this package
-\item \code{fullname}\cr Full name, like \code{"Escherichia coli"}. For the taxonomic ranks genus, species and subspecies, this is the 'pasted' text of genus, species, and subspecies. For all taxonomic ranks higher than genus, this is the name of the taxon.
+\item \code{mo}\cr ID of microorganism as used by this package. \emph{This is a unique identifier.}
+\item \code{fullname}\cr Full name, like \code{"Escherichia coli"}. For the taxonomic ranks genus, species and subspecies, this is the 'pasted' text of genus, species, and subspecies. For all taxonomic ranks higher than genus, this is the name of the taxon. \emph{This is a unique identifier.}
 \item \code{status} \cr Status of the taxon, either "accepted" or "synonym"
 \item \code{kingdom}, \code{phylum}, \code{class}, \code{order}, \code{family}, \code{genus}, \code{species}, \code{subspecies}\cr Taxonomic rank of the microorganism
 \item \code{rank}\cr Text of the taxonomic rank of the microorganism, such as \code{"species"} or \code{"genus"}
-\item \code{ref}\cr Author(s) and year of related scientific publication. This contains only the \emph{first surname} and year of the \emph{latest} authors, e.g. "Wallis \emph{et al.} 2006 \emph{emend.} Smith and Jones 2018" becomes "Smith \emph{et al.}, 2018". This field is directly retrieved from the source specified in the column \code{source}. Moreover, accents were removed to comply with CRAN that only allows ASCII characters, e.g. "Váňová" becomes "Vanova".
+\item \code{ref}\cr Author(s) and year of related scientific publication. This contains only the \emph{first surname} and year of the \emph{latest} authors, e.g. "Wallis \emph{et al.} 2006 \emph{emend.} Smith and Jones 2018" becomes "Smith \emph{et al.}, 2018". This field is directly retrieved from the source specified in the column \code{source}. Moreover, accents were removed to comply with CRAN that only allows ASCII characters.
 \item \code{lpsn}\cr Identifier ('Record number') of the List of Prokaryotic names with Standing in Nomenclature (LPSN). This will be the first/highest LPSN identifier to keep one identifier per row. For example, \emph{Acetobacter ascendens} has LPSN Record number 7864 and 11011. Only the first is available in the \code{microorganisms} data set.
-\item \code{oxygen_tolerance} \cr Oxygen tolerance, either "aerobe", "anaerobe", "anaerobe/microaerophile", "facultative anaerobe", "likely facultative anaerobe", or "microaerophile". These data were retrieved from BacDive (see \emph{Source}). Items that contain "likely" are missing from BacDive and were extrapolated from other species within the same genus to guess the oxygen tolerance. Currently 73.4\% of all ~36 000 bacteria in the data set contain an oxygen tolerance.
+\item \code{oxygen_tolerance} \cr Oxygen tolerance, either "aerobe", "anaerobe", "anaerobe/microaerophile", "facultative anaerobe", "likely facultative anaerobe", or "microaerophile". These data were retrieved from BacDive (see \emph{Source}). Items that contain "likely" are missing from BacDive and were extrapolated from other species within the same genus to guess the oxygen tolerance. Currently 73.4\% of all ~37 000 bacteria in the data set contain an oxygen tolerance.
 \item \code{lpsn_parent}\cr LPSN identifier of the parent taxon
 \item \code{lpsn_renamed_to}\cr LPSN identifier of the currently valid taxon
 \item \code{gbif}\cr Identifier ('taxonID') of the Global Biodiversity Information Facility (GBIF)
@@ -30,7 +30,7 @@ A \link[tibble:tibble]{tibble} with 52 169 observations and 23 variables:
 \item Parte, AC \emph{et al.} (2020). \strong{List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ.} International Journal of Systematic and Evolutionary Microbiology, 70, 5607-5612; \doi{10.1099/ijsem.0.004332}. Accessed from \url{https://lpsn.dsmz.de} on December 11th, 2022.
 \item GBIF Secretariat (2022). GBIF Backbone Taxonomy. Checklist dataset \doi{10.15468/39omei}. Accessed from \url{https://www.gbif.org} on December 11th, 2022.
 \item Reimer, LC \emph{et al.} (2022). \strong{\emph{BacDive} in 2022: the knowledge base for standardized bacterial and archaeal data.} Nucleic Acids Res., 50(D1):D741-D74; \doi{10.1093/nar/gkab961}. Accessed from \url{https://bacdive.dsmz.de} on May 12th, 2023.
-\item Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microoganism', OID 2.16.840.1.114222.4.11.1009 (v12). URL: \url{https://phinvads.cdc.gov}
+\item Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microorganism', OID 2.16.840.1.114222.4.11.1009 (v12). URL: \url{https://phinvads.cdc.gov}
 \item Grimont \emph{et al.} (2007). Antigenic Formulae of the Salmonella Serovars, 9th Edition. WHO Collaborating Centre for Reference and Research on \emph{Salmonella} (WHOCC-SALM).
 \item Bartlett \emph{et al.} (2022). \strong{A comprehensive list of bacterial pathogens infecting humans} \emph{Microbiology} 168:001269; \doi{10.1099/mic.0.001269}
 }
@@ -50,7 +50,7 @@ For example, \emph{Staphylococcus pettenkoferi} was described for the first time
 
 Included taxonomic data are:
 \itemize{
-\item All ~36 000 (sub)species from the kingdoms of Archaea and Bacteria
+\item All ~37 000 (sub)species from the kingdoms of Archaea and Bacteria
 \item ~7 900 (sub)species from the kingdom of Fungi. The kingdom of Fungi is a very large taxon with almost 300,000 different (sub)species, of which most are not microbial (but rather macroscopic, like mushrooms). Because of this, not all fungi fit the scope of this package. Only relevant fungi are covered (such as all species of \emph{Aspergillus}, \emph{Candida}, \emph{Cryptococcus}, \emph{Histoplasma}, \emph{Pneumocystis}, \emph{Saccharomyces} and \emph{Trichophyton}).
 \item ~5 100 (sub)species from the kingdom of Protozoa
 \item ~1 400 (sub)species from 43 other relevant genera from the kingdom of Animalia (such as \emph{Strongyloides} and \emph{Taenia})
@@ -64,7 +64,7 @@ Included taxonomic data are:
 For convenience, some entries were added manually:
 \itemize{
 \item ~1 500 entries of \emph{Salmonella}, such as the city-like serovars and groups A to H
-\item 34 species groups (such as the beta-haemolytic \emph{Streptococcus} groups A to K, coagulase-negative \emph{Staphylococcus} (CoNS), \emph{Mycobacterium tuberculosis} complex, etc.), of which the group compositions are stored in the \link{microorganisms.groups} data set
+\item 36 species groups (such as the beta-haemolytic \emph{Streptococcus} groups A to K, coagulase-negative \emph{Staphylococcus} (CoNS), \emph{Mycobacterium tuberculosis} complex, etc.), of which the group compositions are stored in the \link{microorganisms.groups} data set
 \item 1 entry of \emph{Blastocystis} (\emph{B.  hominis}), although it officially does not exist (Noel \emph{et al.} 2005, PMID 15634993)
 \item 1 entry of \emph{Moraxella} (\emph{M. catarrhalis}), which was formally named \emph{Branhamella catarrhalis} (Catlin, 1970) though this change was never accepted within the field of clinical microbiology
 \item 8 other 'undefined' entries (unknown, unknown Gram-negatives, unknown Gram-positives, unknown yeast, unknown fungus, and unknown anaerobic Gram-pos/Gram-neg bacteria)

man/microorganisms.codes.Rd

@@ -7,7 +7,7 @@
 \format{
 A \link[tibble:tibble]{tibble} with 4 957 observations and 2 variables:
 \itemize{
-\item \code{code}\cr Commonly used code of a microorganism
+\item \code{code}\cr Commonly used code of a microorganism. \emph{This is a unique identifier.}
 \item \code{mo}\cr ID of the microorganism in the \link{microorganisms} data set
 }
 }

man/microorganisms.groups.Rd

@@ -3,9 +3,9 @@
 \docType{data}
 \name{microorganisms.groups}
 \alias{microorganisms.groups}
-\title{Data Set with 507 Microorganisms In Species Groups}
+\title{Data Set with 521 Microorganisms In Species Groups}
 \format{
-A \link[tibble:tibble]{tibble} with 507 observations and 4 variables:
+A \link[tibble:tibble]{tibble} with 521 observations and 4 variables:
 \itemize{
 \item \code{mo_group}\cr ID of the species group / microbiological complex
 \item \code{mo}\cr ID of the microorganism belonging in the species group / microbiological complex

man/mo_property.Rd

@@ -356,7 +356,7 @@ This function uses \code{\link[=as.mo]{as.mo()}} internally, which uses an advan
 \item Parte, AC \emph{et al.} (2020). \strong{List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ.} International Journal of Systematic and Evolutionary Microbiology, 70, 5607-5612; \doi{10.1099/ijsem.0.004332}. Accessed from \url{https://lpsn.dsmz.de} on December 11th, 2022.
 \item GBIF Secretariat (2022). GBIF Backbone Taxonomy. Checklist dataset \doi{10.15468/39omei}. Accessed from \url{https://www.gbif.org} on December 11th, 2022.
 \item Reimer, LC \emph{et al.} (2022). \strong{\emph{BacDive} in 2022: the knowledge base for standardized bacterial and archaeal data.} Nucleic Acids Res., 50(D1):D741-D74; \doi{10.1093/nar/gkab961}. Accessed from \url{https://bacdive.dsmz.de} on May 12th, 2023.
-\item Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microoganism', OID 2.16.840.1.114222.4.11.1009 (v12). URL: \url{https://phinvads.cdc.gov}
+\item Public Health Information Network Vocabulary Access and Distribution System (PHIN VADS). US Edition of SNOMED CT from 1 September 2020. Value Set Name 'Microorganism', OID 2.16.840.1.114222.4.11.1009 (v12). URL: \url{https://phinvads.cdc.gov}
 \item Bartlett A \emph{et al.} (2022). \strong{A comprehensive list of bacterial pathogens infecting humans} \emph{Microbiology} 168:001269; \doi{10.1099/mic.0.001269}
 }
 }

man/plot.Rd

@@ -154,7 +154,7 @@ plot(some_sir_values)
 # when providing the microorganism and antibiotic, colours will show interpretations:
 plot(some_mic_values, mo = "S. aureus", ab = "ampicillin")
 plot(some_disk_values, mo = "Escherichia coli", ab = "cipro")
-plot(some_disk_values, mo = "Escherichia coli", ab = "cipro", language = "uk")
+plot(some_disk_values, mo = "Escherichia coli", ab = "cipro", language = "nl")
 
 \donttest{
 if (require("ggplot2")) {

man/proportion.Rd

@@ -97,13 +97,13 @@ These functions can be used to calculate the (co-)resistance or susceptibility o
 \code{\link[=resistance]{resistance()}} should be used to calculate resistance, \code{\link[=susceptibility]{susceptibility()}} should be used to calculate susceptibility.\cr
 }
 \details{
+\strong{Remember that you should filter your data to let it contain only first isolates!} This is needed to exclude duplicates and to reduce selection bias. Use \code{\link[=first_isolate]{first_isolate()}} to determine them in your data set with one of the four available algorithms.
+
 The function \code{\link[=resistance]{resistance()}} is equal to the function \code{\link[=proportion_R]{proportion_R()}}. The function \code{\link[=susceptibility]{susceptibility()}} is equal to the function \code{\link[=proportion_SI]{proportion_SI()}}.
 
 Use \code{\link[=sir_confidence_interval]{sir_confidence_interval()}} to calculate the confidence interval, which relies on \code{\link[=binom.test]{binom.test()}}, i.e., the Clopper-Pearson method. This function returns a vector of length 2 at default for antimicrobial \emph{resistance}. Change the \code{side} argument to "left"/"min" or "right"/"max" to return a single value, and change the \code{ab_result} argument to e.g. \code{c("S", "I")} to test for antimicrobial \emph{susceptibility}, see Examples.
 
-\strong{Remember that you should filter your data to let it contain only first isolates!} This is needed to exclude duplicates and to reduce selection bias. Use \code{\link[=first_isolate]{first_isolate()}} to determine them in your data set with one of the four available algorithms.
-
-These functions are not meant to count isolates, but to calculate the proportion of resistance/susceptibility. Use the \code{\link[=count]{count()}} functions to count isolates. The function \code{\link[=susceptibility]{susceptibility()}} is essentially equal to \code{count_susceptible() / count_all()}. \emph{Low counts can influence the outcome - the \code{proportion} functions may camouflage this, since they only return the proportion (albeit being dependent on the \code{minimum} argument).}
+These functions are not meant to count isolates, but to calculate the proportion of resistance/susceptibility. Use the \code{\link[=count]{count_*()}} functions to count isolates. The function \code{\link[=susceptibility]{susceptibility()}} is essentially equal to \code{\link[=count_susceptible]{count_susceptible()}}\code{/}\code{\link[=count_all]{count_all()}}. \emph{Low counts can influence the outcome - the \verb{proportion_*()} functions may camouflage this, since they only return the proportion (albeit dependent on the \code{minimum} argument).}
 
 The function \code{\link[=proportion_df]{proportion_df()}} takes any variable from \code{data} that has an \code{\link{sir}} class (created with \code{\link[=as.sir]{as.sir()}}) and calculates the proportions S, I, and R. It also supports grouped variables. The function \code{\link[=sir_df]{sir_df()}} works exactly like \code{\link[=proportion_df]{proportion_df()}}, but adds the number of isolates.
 }

man/translate.Rd

@@ -58,17 +58,12 @@ ab_name("Ciprofloxacin")
 mo_name("Coagulase-negative Staphylococcus (CoNS)")
 
 # setting another language
-set_AMR_locale("Spanish")
+set_AMR_locale("Dutch")
 ab_name("Ciprofloxacin")
 mo_name("Coagulase-negative Staphylococcus (CoNS)")
 
 # setting yet another language
-set_AMR_locale("Greek")
-ab_name("Ciprofloxacin")
-mo_name("Coagulase-negative Staphylococcus (CoNS)")
-
-# setting yet another language
-set_AMR_locale("Ukrainian")
+set_AMR_locale("German")
 ab_name("Ciprofloxacin")
 mo_name("Coagulase-negative Staphylococcus (CoNS)")
 

tests/tinytest.R

@@ -66,13 +66,15 @@ if (tryCatch(isTRUE(AMR:::import_fn("isJob", "rstudioapi")()), error = function(
     }
 
     # start the unit tests
-    out <- test_package("AMR",
-      testdir = ifelse(dir.exists("inst/tinytest"),
-        "inst/tinytest",
-        "tinytest"
-      ),
-      verbose = 99,
-      color = FALSE
+    suppressMessages(
+      out <- test_package("AMR",
+        testdir = ifelse(dir.exists("inst/tinytest"),
+          "inst/tinytest",
+          "tinytest"
+        ),
+        verbose = FALSE,
+        color = FALSE
+      )
     )
     cat("\n\nSUMMARY:\n")
     print(summary(out))

vignettes/SPSS.Rmd.not

@@ -1,231 +0,0 @@
----
-title: "How to import data from SPSS / SAS / Stata"
-author: "Dr. Matthijs Berends"
-date: '`r format(Sys.Date(), "%d %B %Y")`'
-output: 
-  rmarkdown::html_vignette:
-    toc: true
-vignette: >
-  %\VignetteIndexEntry{How to import data from SPSS / SAS / Stata}
-  %\VignetteEncoding{UTF-8}
-  %\VignetteEngine{knitr::rmarkdown}
-editor_options: 
-  chunk_output_type: console
----
-
-```{r setup, include = FALSE, results = 'markup'}
-knitr::opts_chunk$set(
-  collapse = TRUE,
-  comment = "#>"
-)
-# set to original language (English)
-Sys.setlocale(locale = "C")
-library(AMR)
-```
-
-## SPSS / SAS / Stata
-
-SPSS (Statistical Package for the Social Sciences) is probably the most well-known software package for statistical analysis. SPSS is easier to learn than R, because in SPSS you only have to click a menu to run parts of your analysis. Because of its user-friendliness, it is taught at universities and particularly useful for students who are new to statistics. From my experience, I would guess that pretty much all (bio)medical students know it at the time they graduate. SAS and Stata are comparable statistical packages popular in big industries.
-
-## Compared to R
-
-As said, SPSS is easier to learn than R. But SPSS, SAS and Stata come with major downsides when comparing it with R:
-
-* **R is highly modular.**
-
-  The [official R network (CRAN)](https://cran.r-project.org/) features more than 16,000 packages at the time of writing, our `AMR` package being one of them. All these packages were peer-reviewed before publication. Aside from this official channel, there are also developers who choose not to submit to CRAN, but rather keep it on their own public repository, like GitHub. So there may even be a lot more than 14,000 packages out there.
-  
-  Bottom line is, you can really extend it yourself or ask somebody to do this for you. Take for example our `AMR` package. Among other things, it adds reliable reference data to R to help you with the data cleaning and analysis. SPSS, SAS and Stata will never know what a valid MIC value is or what the Gram stain of *E. coli* is. Or that all species of *Klebiella* are resistant to amoxicillin and that Floxapen^®^ is a trade name of flucloxacillin. These facts and properties are often needed to clean existing data, which would be very inconvenient in a software package without reliable reference data. See below for a demonstration.
-  
-* **R is extremely flexible.**
-
-  Because you write the syntax yourself, you can do anything you want. The flexibility in transforming, arranging, grouping and summarising data, or drawing plots, is endless - with SPSS, SAS or Stata you are bound to their algorithms and format styles. They may be a bit flexible, but you can probably never create that very specific publication-ready plot without using other (paid) software. If you sometimes write syntaxes in SPSS to run a complete analysis or to 'automate' some of your work, you could do this a lot less time in R. You will notice that writing syntaxes in R is a lot more nifty and clever than in SPSS. Still, as working with any statistical package, you will have to have knowledge about what you are doing (statistically) and what you are willing to accomplish.
-  
-* **R can be easily automated.**
-
-  Over the last years, [R Markdown](https://rmarkdown.rstudio.com/) has really made an interesting development. With R Markdown, you can very easily produce reports, whether the format has to be Word, PowerPoint, a website, a PDF document or just the raw data to Excel. It even allows the use of a reference file containing the layout style (e.g. fonts and colours) of your organisation. I use this a lot to generate weekly and monthly reports automatically. Just write the code once and enjoy the automatically updated reports at any interval you like.
-  
-  For an even more professional environment, you could create [Shiny apps](https://shiny.rstudio.com/): live manipulation of data using a custom made website. The webdesign knowledge needed (JavaScript, CSS, HTML) is almost *zero*.
-  
-* **R has a huge community.**
-
-  Many R users just ask questions on websites like [StackOverflow.com](https://stackoverflow.com), the largest online community for programmers. At the time of writing, [`r format(suppressWarnings(read.csv("https://data.stackexchange.com/stackoverflow/csv/1674647", quote = '"'))[[1]], big.mark = " ")` R-related questions](https://stackoverflow.com/questions/tagged/r?sort=votes) have already been asked on this platform (that covers questions and answers for any programming language). In my own experience, most questions are answered within a couple of minutes.
-  
-* **R understands any data type, including SPSS/SAS/Stata.**
-
-  And that's not vice versa I'm afraid. You can import data from any source into R. For example from SPSS, SAS and Stata ([link](https://haven.tidyverse.org/)), from Minitab, Epi Info and EpiData ([link](https://cran.r-project.org/package=foreign)), from Excel ([link](https://readxl.tidyverse.org/)), from flat files like CSV, TXT or TSV ([link](https://readr.tidyverse.org/)), or directly from databases and datawarehouses from anywhere on the world ([link](https://dbplyr.tidyverse.org/)). You can even scrape websites to download tables that are live on the internet ([link](https://github.com/hadley/rvest)) or get the results of an API call and transform it into data in only one command ([link](https://github.com/Rdatatable/data.table/wiki/Convenience-features-of-fread)).
-  
-  And the best part - you can export from R to most data formats as well. So you can import an SPSS file, do your analysis neatly in R and export the resulting tables to Excel files for sharing.
-
-* **R is completely free and open-source.**
-
-  No strings attached. It was created and is being maintained by volunteers who believe that (data) science should be open and publicly available to everybody. SPSS, SAS and Stata are quite expensive. IBM SPSS Staticstics only comes with subscriptions nowadays, varying [between USD 1,300 and USD 8,500](https://www.ibm.com/products/spss-statistics/pricing) per user *per year*. SAS Analytics Pro costs [around USD 10,000](https://www.sas.com/store/products-solutions/sas-analytics-pro/prodPERSANL.html) per computer. Stata also has a business model with subscription fees, varying [between USD 600 and USD 2,800](https://www.stata.com/order/new/bus/single-user-licenses/dl/) per computer per year, but lower prices come with a limitation of the number of variables you can work with. And still they do not offer the above benefits of R.
-  
-  If you are working at a midsized or small company, you can save it tens of thousands of dollars by using R instead of e.g. SPSS - gaining even more functions and flexibility. And all R enthousiasts can do as much PR as they want (like I do here), because nobody is officially associated with or affiliated by R. It is really free.
-  
-* **R is (nowadays) the preferred analysis software in academic papers.**
-  
-  At present, R is among the world most powerful statistical languages, and it is generally very popular in science (Bollmann *et al.*,  2017). For all the above reasons, the number of references to R as an analysis method in academic papers [is rising continuously](https://r4stats.com/2014/08/20/r-passes-spss-in-scholarly-use-stata-growing-rapidly/) and has even surpassed SPSS for academic use (Muenchen, 2014). 
-    
-  I believe that the thing with SPSS is, that it has always had a great user interface which is very easy to learn and use. Back when they developed it, they had very little competition, let alone from R. R didn't even had a professional user interface until the last decade (called RStudio, see below). How people used R between the nineties and 2010 is almost completely incomparable to how R is being used now. The language itself [has been restyled completely](https://www.tidyverse.org/packages/) by volunteers who are dedicated professionals in the field of data science. SPSS was great when there was nothing else that could compete. But now in `r max(2019, as.integer(format(Sys.Date(), "%Y")))`, I don't see any reason why SPSS would be of any better use than R.
-  
-To demonstrate the first point:
-
-```{r, warning = FALSE, message = FALSE}
-# not all values are valid MIC values:
-as.mic(0.125)
-as.mic("testvalue")
-
-# the Gram stain is available for all bacteria:
-mo_gramstain("E. coli")
-
-# Klebsiella is intrinsic resistant to amoxicillin, according to EUCAST:
-klebsiella_test <- data.frame(
-  mo = "klebsiella",
-  amox = "S",
-  stringsAsFactors = FALSE
-)
-klebsiella_test # (our original data)
-eucast_rules(klebsiella_test, info = FALSE) # (the edited data by EUCAST rules)
-
-# hundreds of trade names can be translated to a name, trade name or an ATC code:
-ab_name("floxapen")
-ab_tradenames("floxapen")
-ab_atc("floxapen")
-```
-
-## Import data from SPSS/SAS/Stata
-
-### RStudio
-To work with R, probably the best option is to use [RStudio](https://www.rstudio.com/products/rstudio/). It is an open-source and free desktop environment which not only allows you to run R code, but also supports project management, version management, package management and convenient import menus to work with other data sources. You can also install [RStudio Server](https://www.rstudio.com/products/rstudio/) on a private or corporate server, which brings nothing less than the complete RStudio software to you as a website (at home or at work).
-
-To import a data file, just click *Import Dataset* in the Environment tab:
-    
-![](https://msberends.github.io/AMR/import1.png)
-
-If additional packages are needed, RStudio will ask you if they should be installed on beforehand.
-
-In the the window that opens, you can define all options (parameters) that should be used for import and you're ready to go:
-
-![](https://msberends.github.io/AMR/import2.png)
-
-If you want named variables to be imported as factors so it resembles SPSS more, use `as_factor()`.
-
-The difference is this:
-
-```{r, eval = FALSE}
-SPSS_data
-# # A tibble: 4,203 x 4
-#     v001 sex       status    statusage
-#    <dbl> <dbl+lbl> <dbl+lbl>     <dbl>
-#  1 10002 1         1              76.6
-#  2 10004 0         1              59.1
-#  3 10005 1         1              54.5
-#  4 10006 1         1              54.1
-#  5 10007 1         1              57.7
-#  6 10008 1         1              62.8
-#  7 10010 0         1              63.7
-#  8 10011 1         1              73.1
-#  9 10017 1         1              56.7
-# 10 10018 0         1              66.6
-# # ... with 4,193 more rows
-
-as_factor(SPSS_data)
-# # A tibble: 4,203 x 4
-#     v001 sex    status statusage
-#    <dbl> <fct>  <fct>      <dbl>
-#  1 10002 Male   alive       76.6
-#  2 10004 Female alive       59.1
-#  3 10005 Male   alive       54.5
-#  4 10006 Male   alive       54.1
-#  5 10007 Male   alive       57.7
-#  6 10008 Male   alive       62.8
-#  7 10010 Female alive       63.7
-#  8 10011 Male   alive       73.1
-#  9 10017 Male   alive       56.7
-# 10 10018 Female alive       66.6
-# # ... with 4,193 more rows
-```
-
-### Base R
-
-To import data from SPSS, SAS or Stata, you can use the [great `haven` package](https://haven.tidyverse.org/) yourself:
-
-```{r, eval = FALSE}
-# download and install the latest version:
-install.packages("haven")
-# load the package you just installed:
-library(haven)
-```
-
-You can now import files as follows:
-
-#### SPSS
-
-To read files from SPSS into R:
-
-```{r, eval = FALSE}
-# read any SPSS file based on file extension (best way):
-read_spss(file = "path/to/file")
-
-# read .sav or .zsav file:
-read_sav(file = "path/to/file")
-
-# read .por file:
-read_por(file = "path/to/file")
-```
-
-Do not forget about `as_factor()`, as mentioned above.
-
-To export your R objects to the SPSS file format:
-
-```{r, eval = FALSE}
-# save as .sav file:
-write_sav(data = yourdata, path = "path/to/file")
-
-# save as compressed .zsav file:
-write_sav(data = yourdata, path = "path/to/file", compress = TRUE)
-```
-
-#### SAS
-
-To read files from SAS into R:
-
-```{r, eval = FALSE}
-# read .sas7bdat + .sas7bcat files:
-read_sas(data_file = "path/to/file", catalog_file = NULL)
-
-# read SAS transport files (version 5 and version 8):
-read_xpt(file = "path/to/file")
-```
-
-To export your R objects to the SAS file format:
-
-```{r, eval = FALSE}
-# save as regular SAS file:
-write_sas(data = yourdata, path = "path/to/file")
-
-# the SAS transport format is an open format
-# (required for submission of the data to the FDA)
-write_xpt(data = yourdata, path = "path/to/file", version = 8)
-```
-
-#### Stata
-
-To read files from Stata into R:
-
-```{r, eval = FALSE}
-# read .dta file:
-read_stata(file = "/path/to/file")
-
-# works exactly the same:
-read_dta(file = "/path/to/file")
-```
-
-To export your R objects to the Stata file format:
-
-```{r, eval = FALSE}
-# save as .dta file, Stata version 14:
-# (supports Stata v8 until v15 at the time of writing)
-write_dta(data = yourdata, path = "/path/to/file", version = 14)
-```

vignettes/datasets.Rmd

@@ -221,6 +221,12 @@ This data set is in R available as `clinical_breakpoints`, after you load the `A
 
 This data set contains interpretation rules for MIC values and disk diffusion diameters. Included guidelines are CLSI (`r min(as.integer(gsub("[^0-9]", "", subset(clinical_breakpoints, guideline %like% "CLSI")$guideline)))`-`r max(as.integer(gsub("[^0-9]", "", subset(clinical_breakpoints, guideline %like% "CLSI")$guideline)))`) and EUCAST (`r min(as.integer(gsub("[^0-9]", "", subset(clinical_breakpoints, guideline %like% "EUCAST")$guideline)))`-`r max(as.integer(gsub("[^0-9]", "", subset(clinical_breakpoints, guideline %like% "EUCAST")$guideline)))`).
 
+Clinical breakpoints in this package were validated through and imported from [WHONET](https://whonet.org), a free desktop Windows application developed and supported by the WHO Collaborating Centre for Surveillance of Antimicrobial Resistance. More can be read on [their website](https://whonet.org). The developers of WHONET and this `AMR` package have been in contact about sharing their work. We highly appreciate their development on the WHONET software.
+
+The CEO of CLSI and the chairman of EUCAST have endorsed the work and public use of this `AMR` package (and consequently the use of their breakpoints) in June 2023, when future development of distributing clinical breakpoints was discussed in a meeting between CLSI, EUCAST, the WHO, and developers of WHONET and the `AMR` package.
+
+**NOTE:** this `AMR` package (and the WHONET software as well) contains internal methods to apply the guidelines, which is rather complex. For example, some breakpoints must be applied on certain species groups (which are in case of this package available through the `microorganisms.groups` data set). It is important that this is considered when using the breakpoints for own use.
+
 ### Example content
 
 ```{r, echo = FALSE}

vignettes/welcome_to_AMR.Rmd

@@ -22,7 +22,7 @@ knitr::opts_chunk$set(
 )
 ```
 
-Note: to keep the package size as small as possible, we only included this vignette on CRAN. You can read more vignettes on our website about how to conduct AMR data analysis, determine MDROs, find explanation of EUCAST rules, and much more: <https://msberends.github.io/AMR/articles/>.
+Note: to keep the package size as small as possible, we only include this vignette on CRAN. You can read more vignettes on our website about how to conduct AMR data analysis, determine MDROs, find explanation of EUCAST and CLSI breakpoints, and much more: <https://msberends.github.io/AMR/articles/>.
 
 ----