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Calculate the Matching Score for Microorganisms

Source: R/mo_matching_score.R
mo_matching_score.Rd

This algorithm is used by as.mo() and all the mo_* functions to determine the most probable match of taxonomic records based on user input.

Usage

mo_matching_score(x, n)

Arguments

x

Any user input value(s)

n

A full taxonomic name, that exists in microorganisms$fullname

Note

This algorithm was originally described in: Berends MS et al. (2022). AMR: An R Package for Working with Antimicrobial Resistance Data. Journal of Statistical Software, 104(3), 1-31; doi:10.18637/jss.v104.i03 .

Later, the work of Bartlett A et al. about bacterial pathogens infecting humans (2022, doi:10.1099/mic.0.001269 ) was incorporated.

Matching Score for Microorganisms

With ambiguous user input in as.mo() and all the mo_* functions, the returned results are chosen based on their matching score using mo_matching_score(). This matching score \(m\), is calculated as:

mo matching score

where:

  • x is the user input;

  • n is a taxonomic name (genus, species, and subspecies);

  • ln is the length of n;

  • lev is the Levenshtein distance function (counting any insertion as 1, and any deletion or substitution as 2) that is needed to change x into n;

  • pn is the human pathogenic prevalence group of n, as described below;

  • kn is the taxonomic kingdom of n, set as Bacteria = 1, Fungi = 2, Protozoa = 3, Archaea = 4, others = 5.

The grouping into human pathogenic prevalence (\(p\)) is based on recent work from Bartlett et al. (2022, doi:10.1099/mic.0.001269 ) who extensively studied medical-scientific literature to categorise all bacterial species into these groups:

  • Established, if a taxonomic species has infected at least three persons in three or more references. These records have prevalence = 1.0 in the microorganisms data set.

  • Putative, if a taxonomic species has fewer than three known cases. These records have prevalence = 2.0 in the microorganisms data set.

Furthermore,

  • Any other bacterial genus, species or subspecies of which the genus is present in the two aforementioned groups, has prevalence = 2.5 in the microorganisms data set.

  • Any non-bacterial genus, species or subspecies of which the genus is present in the following list, also has prevalence = 2.5 in the microorganisms data set: Absidia, Acanthamoeba, Acremonium, Aedes, Alternaria, Amoeba, Ancylostoma, Angiostrongylus, Anisakis, Anopheles, Apophysomyces, Aspergillus, Aureobasidium, Basidiobolus, Beauveria, Blastocystis, Blastomyces, Candida, Capillaria, Chaetomium, Chrysonilia, Cladophialophora, Cladosporium, Conidiobolus, Contracaecum, Cordylobia, Cryptococcus, Curvularia, Demodex, Dermatobia, Dientamoeba, Diphyllobothrium, Dirofilaria, Echinostoma, Entamoeba, Enterobius, Exophiala, Exserohilum, Fasciola, Fonsecaea, Fusarium, Giardia, Haloarcula, Halobacterium, Halococcus, Hendersonula, Heterophyes, Histomonas, Histoplasma, Hymenolepis, Hypomyces, Hysterothylacium, Leishmania, Malassezia, Malbranchea, Metagonimus, Meyerozyma, Microsporidium, Microsporum, Mortierella, Mucor, Mycocentrospora, Necator, Nectria, Ochroconis, Oesophagostomum, Oidiodendron, Opisthorchis, Pediculus, Phlebotomus, Phoma, Pichia, Piedraia, Pithomyces, Pityrosporum, Pneumocystis, Pseudallescheria, Pseudoterranova, Pulex, Rhizomucor, Rhizopus, Rhodotorula, Saccharomyces, Sarcoptes, Scolecobasidium, Scopulariopsis, Scytalidium, Spirometra, Sporobolomyces, Stachybotrys, Strongyloides, Syngamus, Taenia, Toxocara, Trichinella, Trichobilharzia, Trichoderma, Trichomonas, Trichophyton, Trichosporon, Trichostrongylus, Trichuris, Tritirachium, Trombicula, Trypanosoma, Tunga or Wuchereria.

  • All other records have prevalence = 3.0 in the microorganisms data set.

When calculating the matching score, all characters in \(x\) and \(n\) are ignored that are other than A-Z, a-z, 0-9, spaces and parentheses.

All matches are sorted descending on their matching score and for all user input values, the top match will be returned. This will lead to the effect that e.g., "E. coli" will return the microbial ID of Escherichia coli (\(m = 0.688\), a highly prevalent microorganism found in humans) and not Entamoeba coli (\(m = 0.095\), a less prevalent microorganism in humans), although the latter would alphabetically come first.

Reference Data Publicly Available

All data sets in this AMR package (about microorganisms, antibiotics, R/SI interpretation, EUCAST rules, etc.) are publicly and freely available for download in the following formats: R, MS Excel, Apache Feather, Apache Parquet, SPSS, SAS, and Stata. We also provide tab-separated plain text files that are machine-readable and suitable for input in any software program, such as laboratory information systems. Please visit our website for the download links. The actual files are of course available on our GitHub repository.

Author

Dr. Matthijs Berends

Examples

as.mo("E. coli")
#> Class 'mo'
#> [1] B_ESCHR_COLI
mo_uncertainties()
#> Matching scores are based on the resemblance between the input and the full
#> taxonomic name, and the pathogenicity in humans according to Bartlett et
#> al. (2022). See ?mo_matching_score.
#> 
#> --------------------------------------------------------------------------------
#> "K. pneumoniae" -> Klebsiella pneumoniae (B_KLBSL_PNMN, 0.786)
#>                    Based on input "K pneumoniae"
#> Also matched: Klebsiella pneumoniae ozaenae (0.707), Klebsiella
#>               pneumoniae pneumoniae (0.688), Klebsiella pneumoniae rhinoscleromatis
#>               (0.658), Klebsiella pasteurii (0.500), Klebsiella planticola (0.500),
#>               Kingella potus (0.250), Kosakonia pseudosacchari (0.217),
#>               Kroppenstedtia pulmonis (0.203), Kaistella palustris (0.200), Kocuria
#>               palustris (0.200), Kocuria pelophila (0.200), Kocuria polaris (0.200),
#>               Kibdelosporangium phytohabitans (0.188), Kitasatospora putterlickiae
#>               (0.179), Kibdelosporangium philippinense (0.177), Kalamiella piersonii
#>               (0.175), Kitasatospora psammotica (0.174), Kallotenue papyrolyticum
#>               (0.167), Kangiella profundi (0.167), Kangsaoukella pontilimi (0.167),
#>               Katagnymene pelagic (0.167), Keratinibaculum paraultunense (0.167),
#>               Kibdelosporangium persicum (0.167), Kitasatoa purpurea (0.167) and
#>               Kitasatospora paracochleata (0.167) [showing first 25]

mo_matching_score(
  x = "E. coli",
  n = c("Escherichia coli", "Entamoeba coli")
)
#> [1] 0.6875000 0.0952381