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AMR 0.7.1.9105

Last updated: 12-Oct-2019

Breaking

Determination of first isolates now excludes all 'unknown' microorganisms at default, i.e. microbial code "UNKNOWN". They can be included with the new parameter include_unknown:
```
first_isolate(..., include_unknown = TRUE)
```
For WHONET users, this means that all records/isolates with organism code "con" (contamination) will be excluded at default, since as.mo("con") = "UNKNOWN". The function always shows a note with the number of 'unknown' microorganisms that were included or excluded.
For code consistency, classes ab and mo will now be preserved in any subsetting or assignment. For the sake of data integrity, this means that invalid assignments will now result in NA:
```
# how it works in base R:
x <- factor("A")
x[1] <- "B"
#> Warning message:
#> invalid factor level, NA generated

# how it now works similarly for classes 'mo' and 'ab':
x <- as.mo("E. coli")
x[1] <- "testvalue"
#> Warning message:
#> invalid microorganism code, NA generated
```
This is important, because a value like "testvalue" could never be understood by e.g. mo_name(), although the class would suggest a valid microbial code.
Function freq() has moved to a new package, clean (CRAN link), since creating frequency tables actually does not fit the scope of this package. The freq() function still works, since it is re-exported from the clean package (which will be installed automatically upon updating this AMR package).
Renamed data set septic_patients to example_isolates

New

Function bug_drug_combinations() to quickly get a data.frame with the results of all bug-drug combinations in a data set. The column containing microorganism codes is guessed automatically and its input is transformed with mo_shortname() at default:

x <- bug_drug_combinations(example_isolates)
#> NOTE: Using column `mo` as input for `col_mo`.
x[1:4, ]
#>             mo  ab S I R total
#> 1 A. baumannii AMC 0 0 3     3
#> 2 A. baumannii AMK 0 0 0     0
#> 3 A. baumannii AMP 0 0 3     3
#> 4 A. baumannii AMX 0 0 3     3
#> NOTE: Use 'format()' on this result to get a publicable/printable format.

# change the transformation with the FUN argument to anything you like:
x <- bug_drug_combinations(example_isolates, FUN = mo_gramstain)
#> NOTE: Using column `mo` as input for `col_mo`.
x[1:4, ]
#>              mo  ab   S  I   R total
#> 1 Gram-negative AMC 469 89 174   732
#> 2 Gram-negative AMK 251  0   2   253
#> 3 Gram-negative AMP 227  0 405   632
#> 4 Gram-negative AMX 227  0 405   632
#> NOTE: Use 'format()' on this result to get a publicable/printable format.

You can format this to a printable format, ready for reporting or exporting to e.g. Excel with the base R format() function:

format(x, combine_IR = FALSE)

Additional way to calculate co-resistance, i.e. when using multiple antimicrobials as input for portion_* functions or count_* functions. This can be used to determine the empiric susceptibility of a combination therapy. A new parameter only_all_tested (which defaults to FALSE) replaces the old also_single_tested and can be used to select one of the two methods to count isolates and calculate portions. The difference can be seen in this example table (which is also on the portion and count help pages), where the %SI is being determined:

# --------------------------------------------------------------------
#                     only_all_tested = FALSE  only_all_tested = TRUE
#                     -----------------------  -----------------------
#  Drug A    Drug B   include as  include as   include as  include as
#                     numerator   denominator  numerator   denominator
# --------  --------  ----------  -----------  ----------  -----------
#  S or I    S or I       X            X            X            X
#    R       S or I       X            X            X            X
#   <NA>     S or I       X            X            -            -
#  S or I      R          X            X            X            X
#    R         R          -            X            -            X
#   <NA>       R          -            -            -            -
#  S or I     <NA>        X            X            -            -
#    R        <NA>        -            -            -            -
#   <NA>      <NA>        -            -            -            -
# --------------------------------------------------------------------

Since this is a major change, usage of the old also_single_tested will throw an informative error that it has been replaced by only_all_tested.

tibble printing support for classes rsi, mic, disk, ab mo. When using tibbles containing antimicrobial columns, values S will print in green, values I will print in yellow and values R will print in red. Microbial IDs (class mo) will emphasise on the genus and species, not on the kingdom.
```
# (run this on your own console, as this page does not support colour printing)
library(dplyr)
example_isolates %>%
  select(mo:AMC) %>% 
  as_tibble()
```

Changed

Many algorithm improvements for as.mo() (of which some led to additions to the microorganisms data set). Many thanks to all contributors that helped improving the algorithms.
- Self-learning algorithm - the function now gains experience from previously determined microorganism IDs and learns from it (yielding 80-95% speed improvement for any guess after the first try)
- Big improvement for misspelled input
- These new trivial names known to the field are now understood: meningococcus, gonococcus, pneumococcus
- Updated to the latest taxonomic data (updated to August 2019, from the International Journal of Systematic and Evolutionary Microbiology
- Added support for Viridans Group Streptococci (VGS) and Milleri Group Streptococci (MGS)
- Added support for Blastocystis
- Added support for 5,000 new fungi
- Added support for unknown yeasts and fungi
- Changed most microorganism IDs to improve readability. For example, the old code B_ENTRC_FAE could have been both E. faecalis and E. faecium. Its new code is B_ENTRC_FCLS and E. faecium has become B_ENTRC_FACM. Also, the Latin character æ (ae) is now preserved at the start of each genus and species abbreviation. For example, the old code for Aerococcus urinae was B_ARCCC_NAE. This is now B_AERCC_URIN. IMPORTANT: Old microorganism IDs are still supported, but support will be dropped in a future version. Use as.mo() on your old codes to transform them to the new format. Using functions from the mo_* family (like mo_name() and mo_gramstain()) on old codes, will throw a warning.
More intelligent guessing for as.ab(), including bidirectional language support
Added support for the German national guideline (3MRGN/4MRGN) in the mdro() function, to determine multi-drug resistant organisms
Function eucast_rules():
- Fixed a bug for Yersinia pseudotuberculosis
- Added more informative errors and warnings
- Printed info now distinguishes between added and changes values
- Using Verbose mode (i.e. eucast_rules(..., verbose = TRUE)) returns more informative and readable output
- Using factors as input now adds missing factors levels when the function changes antibiotic results
Improved the internal auto-guessing function for determining antimicrobials in your data set (AMR:::get_column_abx())
Removed class atc - using as.atc() is now deprecated in favour of ab_atc() and this will return a character, not the atc class anymore
Removed deprecated functions abname(), ab_official(), atc_name(), atc_official(), atc_property(), atc_tradenames(), atc_trivial_nl()
Fix and speed improvement for mo_shortname()
Fix for using mo_* functions where the coercion uncertainties and failures would not be available through mo_uncertainties() and mo_failures() anymore
Deprecated the country parameter of mdro() in favour of the already existing guideline parameter to support multiple guidelines within one country
The name of RIF is now Rifampicin instead of Rifampin
The antibiotics data set is now sorted by name and all cephalosporins now have their generation between brackets
Speed improvement for guess_ab_col() which is now 30 times faster for antibiotic abbreviations
Improved filter_ab_class() to be more reliable and to support 5th generation cephalosporins
Function availability() now uses portion_R() instead of portion_IR(), to comply with EUCAST insights
Functions age() and age_groups() now have a na.rm parameter to remove empty values
Renamed function p.symbol() to p_symbol() (the former is now deprecated and will be removed in a future version)
Using negative values for x in age_groups() will now introduce NAs and not return an error anymore
Fix for determining the system's language
Fix for key_antibiotics() on foreign systems
Added 80 new LIS codes for microorganisms
Relabeled the factor levels of mdr_tb()
Added more MIC factor levels (as.mic())

Other

Added Prof. Dr. Casper Albers as doctoral advisor and added Dr. Judith Fonville, Eric Hazenberg, Dr. Bart Meijer, Dr. Dennis Souverein and Annick Lenglet as contributors
Cleaned the coding style of every single syntax line in this package with the help of the lintr package

AMR 0.7.1

New

Function rsi_df() to transform a data.frame to a data set containing only the microbial interpretation (S, I, R), the antibiotic, the percentage of S/I/R and the number of available isolates. This is a convenient combination of the existing functions count_df() and portion_df() to immediately show resistance percentages and number of available isolates:
```
septic_patients %>%
  select(AMX, CIP) %>%
  rsi_df()
#      antibiotic  interpretation      value  isolates
# 1   Amoxicillin              SI  0.4442636       546
# 2   Amoxicillin               R  0.5557364       683
# 3 Ciprofloxacin              SI  0.8381831      1181
# 4 Ciprofloxacin               R  0.1618169       228
```
Support for all scientifically published pathotypes of E. coli to date (that we could find). Supported are:
- AIEC (Adherent-Invasive E. coli)
- ATEC (Atypical Entero-pathogenic E. coli)
- DAEC (Diffusely Adhering E. coli)
- EAEC (Entero-Aggresive E. coli)
- EHEC (Entero-Haemorrhagic E. coli)
- EIEC (Entero-Invasive E. coli)
- EPEC (Entero-Pathogenic E. coli)
- ETEC (Entero-Toxigenic E. coli)
- NMEC (Neonatal Meningitis‐causing E. coli)
- STEC (Shiga-toxin producing E. coli)
- UPEC (Uropathogenic E. coli)
All these lead to the microbial ID of E. coli:
```
as.mo("UPEC")
# B_ESCHR_COL
mo_name("UPEC")
# "Escherichia coli"
mo_gramstain("EHEC")
# "Gram-negative"
```
Function mo_info() as an analogy to ab_info(). The mo_info() prints a list with the full taxonomy, authors, and the URL to the online database of a microorganism
Function mo_synonyms() to get all previously accepted taxonomic names of a microorganism

Changed

Column names of output count_df() and portion_df() are now lowercase
Fixed bug in translation of microorganism names
Fixed bug in determining taxonomic kingdoms
Algorithm improvements for as.ab() and as.mo() to understand even more severely misspelled input
Function as.ab() now allows spaces for coercing antibiotics names
Added ggplot2 methods for automatically determining the scale type of classes mo and ab
Added names of object in the header in frequency tables, even when using pipes
Prevented "bacteria" from getting coerced by as.ab() because Bacterial is a brand name of trimethoprim (TMP)
Fixed a bug where setting an antibiotic would not work for eucast_rules() and mdro()
Fixed a EUCAST rule for Staphylococci, where amikacin resistance would not be inferred from tobramycin
Removed latest_annual_release from the catalogue_of_life_version() function
Removed antibiotic code PVM1 from the antibiotics data set as this was a duplicate of PME
Fixed bug where not all old taxonomic names would be printed, when using a vector as input for as.mo()
Manually added Trichomonas vaginalis from the kingdom of Protozoa, which is missing from the Catalogue of Life
Small improvements to plot() and barplot() for MIC and RSI classes
Allow Catalogue of Life IDs to be coerced by as.mo()

Other

Fixed a note thrown by CRAN tests

AMR 0.7.0

New

Support for translation of disk diffusion and MIC values to RSI values (i.e. antimicrobial interpretations). Supported guidelines are EUCAST (2011 to 2019) and CLSI (2011 to 2019). Use as.rsi() on an MIC value (created with as.mic()), a disk diffusion value (created with the new as.disk()) or on a complete date set containing columns with MIC or disk diffusion values.
Function mo_name() as alias of mo_fullname()
Added guidelines of the WHO to determine multi-drug resistance (MDR) for TB (mdr_tb()) and added a new vignette about MDR. Read this tutorial here on our website.

Changed

Fixed a critical bug in first_isolate() where missing species would lead to incorrect FALSEs. This bug was not present in AMR v0.5.0, but was in v0.6.0 and v0.6.1.
Fixed a bug in eucast_rules() where antibiotics from WHONET software would not be recognised
Completely reworked the antibiotics data set:
- All entries now have 3 different identifiers:
  - Column ab contains a human readable EARS-Net code, used by ECDC and WHO/WHONET - this is the primary identifier used in this package
  - Column atc contains the ATC code, used by WHO/WHOCC
  - Column cid contains the CID code (Compound ID), used by PubChem
- Based on the Compound ID, almost 5,000 official brand names have been added from many different countries
- All references to antibiotics in our package now use EARS-Net codes, like AMX for amoxicillin
- Functions atc_certe, ab_umcg and atc_trivial_nl have been removed
- All atc_* functions are superceded by ab_* functions
- All output will be translated by using an included translation file which can be viewed here.
  
  Please create an issue in one of our repositories if you want additions in this file.
Improvements to plotting AMR results with ggplot_rsi():
- New parameter colours to set the bar colours
- New parameters title, subtitle, caption, x.title and y.title to set titles and axis descriptions
Improved intelligence of looking up antibiotic columns in a data set using guess_ab_col()
Added ~5,000 more old taxonomic names to the microorganisms.old data set, which leads to better results finding when using the as.mo() function
This package now honours the new EUCAST insight (2019) that S and I are but classified as susceptible, where I is defined as 'increased exposure' and not 'intermediate' anymore. For functions like portion_df() and count_df() this means that their new parameter combine_SI is TRUE at default. Our plotting function ggplot_rsi() also reflects this change since it uses count_df() internally.
The age() function gained a new parameter exact to determine ages with decimals
Removed deprecated functions guess_mo(), guess_atc(), EUCAST_rules(), interpretive_reading(), rsi()
Frequency tables (freq()):
- speed improvement for microbial IDs
- fixed factor level names for R Markdown
- when all values are unique it now shows a message instead of a warning
- support for boxplots:
```
septic_patients %>% 
  freq(age) %>% 
  boxplot()
# grouped boxplots:
septic_patients %>% 
  group_by(hospital_id) %>% 
  freq(age) %>%
  boxplot()
```
Removed all hardcoded EUCAST rules and replaced them with a new reference file which can be viewed here.

Please create an issue in one of our repositories if you want changes in this file.
Added ceftazidim intrinsic resistance to Streptococci
Changed default settings for age_groups(), to let groups of fives and tens end with 100+ instead of 120+
Fix for freq() for when all values are NA
Fix for first_isolate() for when dates are missing
Improved speed of guess_ab_col()
Function as.mo() now gently interprets any number of whitespace characters (like tabs) as one space
Function as.mo() now returns UNKNOWN for "con" (WHONET ID of 'contamination') and returns NA for "xxx"(WHONET ID of 'no growth')
Small algorithm fix for as.mo()
Removed viruses from data set microorganisms.codes and cleaned it up
Fix for mo_shortname() where species would not be determined correctly

Other

Support for R 3.6.0 and later by providing support for staged install

AMR 0.6.1

Changed

Fixed a critical bug when using eucast_rules() with verbose = TRUE
Coercion of microbial IDs are now written to the package namespace instead of the user's home folder, to comply with the CRAN policy

AMR 0.6.0

New website!

We've got a new website: https://msberends.gitlab.io/AMR (built with the great pkgdown)

Contains the complete manual of this package and all of its functions with an explanation of their parameters
Contains a comprehensive tutorial about how to conduct antimicrobial resistance analysis, import data from WHONET or SPSS and many more.

New

BREAKING: removed deprecated functions, parameters and references to 'bactid'. Use as.mo() to identify an MO code.
Catalogue of Life as a new taxonomic source for data about microorganisms, which also contains all ITIS data we used previously. The microorganisms data set now contains:
- All ~55,000 (sub)species from the kingdoms of Archaea, Bacteria and Protozoa
- All ~3,000 (sub)species from these orders of the kingdom of Fungi: Eurotiales, Onygenales, Pneumocystales, Saccharomycetales and Schizosaccharomycetales (covering at least like all species of Aspergillus, Candida, Pneumocystis, Saccharomyces and Trichophyton)
- All ~2,000 (sub)species from ~100 other relevant genera, from the kingdoms of Animalia and Plantae (like Strongyloides and Taenia)
- All ~15,000 previously accepted names of included (sub)species that have been taxonomically renamed
- The responsible author(s) and year of scientific publication
  
  This data is updated annually - check the included version with the new function catalogue_of_life_version().
- Due to this change, some mo codes changed (e.g. Streptococcus changed from B_STRPTC to B_STRPT). A translation table is used internally to support older microorganism IDs, so users will not notice this difference.
- New function mo_rank() for the taxonomic rank (genus, species, infraspecies, etc.)
- New function mo_url() to get the direct URL of a species from the Catalogue of Life
Support for data from WHONET and EARS-Net (European Antimicrobial Resistance Surveillance Network):
- Exported files from WHONET can be read and used in this package. For functions like first_isolate() and eucast_rules(), all parameters will be filled in automatically.
- This package now knows all antibiotic abbrevations by EARS-Net (which are also being used by WHONET) - the antibiotics data set now contains a column ears_net.
- The function as.mo() now knows all WHONET species abbreviations too, because almost 2,000 microbial abbreviations were added to the microorganisms.codes data set.

New filters for antimicrobial classes. Use these functions to filter isolates on results in one of more antibiotics from a specific class:

filter_aminoglycosides()
filter_carbapenems()
filter_cephalosporins()
filter_1st_cephalosporins()
filter_2nd_cephalosporins()
filter_3rd_cephalosporins()
filter_4th_cephalosporins()
filter_fluoroquinolones()
filter_glycopeptides()
filter_macrolides()
filter_tetracyclines()

The antibiotics data set will be searched, after which the input data will be checked for column names with a value in any abbreviations, codes or official names found in the antibiotics data set. For example:

septic_patients %>% filter_glycopeptides(result = "R")
# Filtering on glycopeptide antibacterials: any of `vanc` or `teic` is R
septic_patients %>% filter_glycopeptides(result = "R", scope = "all")
# Filtering on glycopeptide antibacterials: all of `vanc` and `teic` is R

All ab_* functions are deprecated and replaced by atc_* functions:
```
ab_property -> atc_property()
ab_name -> atc_name()
ab_official -> atc_official()
ab_trivial_nl -> atc_trivial_nl()
ab_certe -> atc_certe()
ab_umcg -> atc_umcg()
ab_tradenames -> atc_tradenames()
```
These functions use as.atc() internally. The old atc_property has been renamed atc_online_property(). This is done for two reasons: firstly, not all ATC codes are of antibiotics (ab) but can also be of antivirals or antifungals. Secondly, the input must have class atc or must be coerable to this class. Properties of these classes should start with the same class name, analogous to as.mo() and e.g. mo_genus.
New functions set_mo_source() and get_mo_source() to use your own predefined MO codes as input for as.mo() and consequently all mo_* functions
Support for the upcoming dplyr version 0.8.0
New function guess_ab_col() to find an antibiotic column in a table
New function mo_failures() to review values that could not be coerced to a valid MO code, using as.mo(). This latter function will now only show a maximum of 10 uncoerced values and will refer to mo_failures().
New function mo_uncertainties() to review values that could be coerced to a valid MO code using as.mo(), but with uncertainty.
New function mo_renamed() to get a list of all returned values from as.mo() that have had taxonomic renaming
New function age() to calculate the (patients) age in years
New function age_groups() to split ages into custom or predefined groups (like children or elderly). This allows for easier demographic antimicrobial resistance analysis per age group.
New function ggplot_rsi_predict() as well as the base R plot() function can now be used for resistance prediction calculated with resistance_predict():
```
x <- resistance_predict(septic_patients, col_ab = "amox")
plot(x)
ggplot_rsi_predict(x)
```

Functions filter_first_isolate() and filter_first_weighted_isolate() to shorten and fasten filtering on data sets with antimicrobial results, e.g.:

septic_patients %>% filter_first_isolate(...)
# or
filter_first_isolate(septic_patients, ...)

is equal to:

septic_patients %>%
  mutate(only_firsts = first_isolate(septic_patients, ...)) %>%
  filter(only_firsts == TRUE) %>%
  select(-only_firsts)

New function availability() to check the number of available (non-empty) results in a data.frame
New vignettes about how to conduct AMR analysis, predict antimicrobial resistance, use the G-test and more. These are also available (and even easier readable) on our website: https://msberends.gitlab.io/AMR.

Changed

Function eucast_rules():
- Updated EUCAST Clinical breakpoints to version 9.0 of 1 January 2019, the data set septic_patients now reflects these changes
- Fixed a critical bug where some rules that depend on previous applied rules would not be applied adequately
- Emphasised in manual that penicillin is meant as benzylpenicillin (ATC J01CE01)
- New info is returned when running this function, stating exactly what has been changed or added. Use eucast_rules(..., verbose = TRUE) to get a data set with all changed per bug and drug combination.
Removed data sets microorganisms.oldDT, microorganisms.prevDT, microorganisms.unprevDT and microorganismsDT since they were no longer needed and only contained info already available in the microorganisms data set
Added 65 antibiotics to the antibiotics data set, from the Pharmaceuticals Community Register of the European Commission
Removed columns atc_group1_nl and atc_group2_nl from the antibiotics data set
Functions atc_ddd() and atc_groups() have been renamed atc_online_ddd() and atc_online_groups(). The old functions are deprecated and will be removed in a future version.
Function guess_mo() is now deprecated in favour of as.mo() and will be removed in future versions
Function guess_atc() is now deprecated in favour of as.atc() and will be removed in future versions
Improvements for as.mo():
- Now handles incorrect spelling, like i instead of y and f instead of ph:
```
# mo_fullname() uses as.mo() internally

mo_fullname("Sthafilokockus aaureuz")
#> [1] "Staphylococcus aureus"

mo_fullname("S. klossi")
#> [1] "Staphylococcus kloosii"
```
- Uncertainty of the algorithm is now divided into four levels, 0 to 3, where the default allow_uncertain = TRUE is equal to uncertainty level 2. Run ?as.mo for more info about these levels.
```
# equal:
as.mo(..., allow_uncertain = TRUE)
as.mo(..., allow_uncertain = 2)

# also equal:
as.mo(..., allow_uncertain = FALSE)
as.mo(..., allow_uncertain = 0)
```
  Using as.mo(..., allow_uncertain = 3) could lead to very unreliable results.
- Implemented the latest publication of Becker et al. (2019), for categorising coagulase-negative Staphylococci
- All microbial IDs that found are now saved to a local file ~/.Rhistory_mo. Use the new function clean_mo_history() to delete this file, which resets the algorithms.
- Incoercible results will now be considered 'unknown', MO code UNKNOWN. On foreign systems, properties of these will be translated to all languages already previously supported: German, Dutch, French, Italian, Spanish and Portuguese:
```
mo_genus("qwerty", language = "es")
# Warning: 
# one unique value (^= 100.0%) could not be coerced and is considered 'unknown': "qwerty". Use mo_failures() to review it.
#> [1] "(género desconocido)"
```
- Fix for vector containing only empty values
- Finds better results when input is in other languages
- Better handling for subspecies
- Better handling for Salmonellae, especially the 'city like' serovars like Salmonella London
- Understanding of highly virulent E. coli strains like EIEC, EPEC and STEC
- There will be looked for uncertain results at default - these results will be returned with an informative warning
- Manual (help page) now contains more info about the algorithms
- Progress bar will be shown when it takes more than 3 seconds to get results
- Support for formatted console text
- Console will return the percentage of uncoercable input
Function first_isolate():
- Fixed a bug where distances between dates would not be calculated right - in the septic_patients data set this yielded a difference of 0.15% more isolates
- Will now use a column named like "patid" for the patient ID (parameter col_patientid), when this parameter was left blank
- Will now use a column named like "key(...)ab" or "key(...)antibiotics" for the key antibiotics (parameter col_keyantibiotics()), when this parameter was left blank
- Removed parameter output_logical, the function will now always return a logical value
- Renamed parameter filter_specimen to specimen_group, although using filter_specimen will still work
A note to the manual pages of the portion functions, that low counts can influence the outcome and that the portion functions may camouflage this, since they only return the portion (albeit being dependent on the minimum parameter)
Merged data sets microorganisms.certe and microorganisms.umcg into microorganisms.codes
Function mo_taxonomy() now contains the kingdom too
Reduce false positives for is.rsi.eligible() using the new threshold parameter
New colours for scale_rsi_colours()
Summaries of class mo will now return the top 3 and the unique count, e.g. using summary(mo)
Small text updates to summaries of class rsi and mic
Function as.rsi():
- Now gives a warning when inputting MIC values
- Now accepts high and low resistance: "HIGH S" will return S
Frequency tables (freq() function):
- Support for tidyverse quasiquotation! Now you can create frequency tables of function outcomes:
```
# Determine genus of microorganisms (mo) in `septic_patients` data set:
# OLD WAY
septic_patients %>%
  mutate(genus = mo_genus(mo)) %>%
  freq(genus)
# NEW WAY
septic_patients %>% 
  freq(mo_genus(mo))

# Even supports grouping variables:
septic_patients %>%
  group_by(gender) %>% 
  freq(mo_genus(mo))
```
- Header info is now available as a list, with the header function
- The parameter header is now set to TRUE at default, even for markdown
- Added header info for class mo to show unique count of families, genera and species
- Now honours the decimal.mark setting, which just like format defaults to getOption("OutDec")
- The new big.mark parameter will at default be "," when decimal.mark = "." and "." otherwise
- Fix for header text where all observations are NA
- New parameter droplevels to exclude empty factor levels when input is a factor
- Factor levels will be in header when present in input data (maximum of 5)
- Fix for using select() on frequency tables
Function scale_y_percent() now contains the limits parameter
Automatic parameter filling for mdro(), key_antibiotics() and eucast_rules()
Updated examples for resistance prediction (resistance_predict() function)
Fix for as.mic() to support more values ending in (several) zeroes
if using different lengths of pattern and x in %like%, it will now return the call

Other

Updated licence text to emphasise GPL 2.0 and that this is an R package.

AMR 0.5.0

New

Repository moved to GitLab: https://gitlab.com/msberends/AMR
Function count_all to get all available isolates (that like all portion_* and count_* functions also supports summarise and group_by), the old n_rsi is now an alias of count_all
Function get_locale to determine language for language-dependent output for some mo_* functions. This is now the default value for their language parameter, by which the system language will be used at default.
Data sets microorganismsDT, microorganisms.prevDT, microorganisms.unprevDT and microorganisms.oldDT to improve the speed of as.mo. They are for reference only, since they are primarily for internal use of as.mo.
Function read.4D to read from the 4D database of the MMB department of the UMCG
Functions mo_authors and mo_year to get specific values about the scientific reference of a taxonomic entry

Changed

Functions MDRO, BRMO, MRGN and EUCAST_exceptional_phenotypes were renamed to mdro, brmo, mrgn and eucast_exceptional_phenotypes
EUCAST_rules was renamed to eucast_rules, the old function still exists as a deprecated function
Big changes to the eucast_rules function:
- Now also applies rules from the EUCAST 'Breakpoint tables for bacteria', version 8.1, 2018, http://www.eucast.org/clinical_breakpoints/ (see Source of the function)
- New parameter rules to specify which rules should be applied (expert rules, breakpoints, others or all)
- New parameter verbose which can be set to TRUE to get very specific messages about which columns and rows were affected
- Better error handling when rules cannot be applied (i.e. new values could not be inserted)
- The number of affected values will now only be measured once per row/column combination
- Data set septic_patients now reflects these changes
- Added parameter pipe for piperacillin (J01CA12), also to the mdro function
- Small fixes to EUCAST clinical breakpoint rules
Added column kingdom to the microorganisms data set, and function mo_kingdom to look up values
Tremendous speed improvement for as.mo (and subsequently all mo_* functions), as empty values wil be ignored a priori
Fewer than 3 characters as input for as.mo will return NA

Function as.mo (and all mo_* wrappers) now supports genus abbreviations with "species" attached

as.mo("E. species")        # B_ESCHR
mo_fullname("E. spp.")     # "Escherichia species"
as.mo("S. spp")            # B_STPHY
mo_fullname("S. species")  # "Staphylococcus species"

Added parameter combine_IR (TRUE/FALSE) to functions portion_df and count_df, to indicate that all values of I and R must be merged into one, so the output only consists of S vs. IR (susceptible vs. non-susceptible)
Fix for portion_*(..., as_percent = TRUE) when minimal number of isolates would not be met
Added parameter also_single_tested for portion_* and count_* functions to also include cases where not all antibiotics were tested but at least one of the tested antibiotics includes the target antimicribial interpretation, see ?portion
Using portion_* functions now throws a warning when total available isolate is below parameter minimum
Functions as.mo, as.rsi, as.mic, as.atc and freq will not set package name as attribute anymore
Frequency tables - freq():
- Support for grouping variables, test with:
```
septic_patients %>% 
  group_by(hospital_id) %>% 
  freq(gender)
```
- Support for (un)selecting columns:
```
septic_patients %>% 
  freq(hospital_id) %>% 
  select(-count, -cum_count) # only get item, percent, cum_percent
```
- Check for hms::is.hms
- Now prints in markdown at default in non-interactive sessions
- No longer adds the factor level column and sorts factors on count again
- Support for class difftime
- New parameter na, to choose which character to print for empty values
- New parameter header to turn the header info off (default when markdown = TRUE)
- New parameter title to manually setbthe title of the frequency table
first_isolate now tries to find columns to use as input when parameters are left blank
Improvements for MDRO algorithm (function mdro)
Data set septic_patients is now a data.frame, not a tibble anymore
Removed diacritics from all authors (columns microorganisms$ref and microorganisms.old$ref) to comply with CRAN policy to only allow ASCII characters
Fix for mo_property not working properly
Fix for eucast_rules where some Streptococci would become ceftazidime R in EUCAST rule 4.5
Support for named vectors of class mo, useful for top_freq()
ggplot_rsi and scale_y_percent have breaks parameter
AI improvements for as.mo:
- "CRS" -> Stenotrophomonas maltophilia
- "CRSM" -> Stenotrophomonas maltophilia
- "MSSA" -> Staphylococcus aureus
- "MSSE" -> Staphylococcus epidermidis
Fix for join functions
Speed improvement for is.rsi.eligible, now 15-20 times faster
In g.test, when sum(x) is below 1000 or any of the expected values is below 5, Fisher's Exact Test will be suggested
ab_name will try to fall back on as.atc when no results are found
Removed the addin to view data sets
Percentages will now will rounded more logically (e.g. in freq function)

Other

New dependency on package crayon, to support formatted text in the console
Dependency tidyr is now mandatory (went to Import field) since portion_df and count_df rely on it
Updated vignettes to comply with README

AMR 0.4.0

New

The data set microorganisms now contains all microbial taxonomic data from ITIS (kingdoms Bacteria, Fungi and Protozoa), the Integrated Taxonomy Information System, available via https://itis.gov. The data set now contains more than 18,000 microorganisms with all known bacteria, fungi and protozoa according ITIS with genus, species, subspecies, family, order, class, phylum and subkingdom. The new data set microorganisms.old contains all previously known taxonomic names from those kingdoms.

New functions based on the existing function mo_property:

Taxonomic names: mo_phylum, mo_class, mo_order, mo_family, mo_genus, mo_species, mo_subspecies
Semantic names: mo_fullname, mo_shortname
Microbial properties: mo_type, mo_gramstain
Author and year: mo_ref

They also come with support for German, Dutch, French, Italian, Spanish and Portuguese:

mo_gramstain("E. coli")
# [1] "Gram negative"
mo_gramstain("E. coli", language = "de") # German
# [1] "Gramnegativ"
mo_gramstain("E. coli", language = "es") # Spanish
# [1] "Gram negativo"
mo_fullname("S. group A", language = "pt") # Portuguese
# [1] "Streptococcus grupo A"

Furthermore, former taxonomic names will give a note about the current taxonomic name:

mo_gramstain("Esc blattae")
# Note: 'Escherichia blattae' (Burgess et al., 1973) was renamed 'Shimwellia blattae' (Priest and Barker, 2010)
# [1] "Gram negative"

Functions count_R, count_IR, count_I, count_SI and count_S to selectively count resistant or susceptible isolates
- Extra function count_df (which works like portion_df) to get all counts of S, I and R of a data set with antibiotic columns, with support for grouped variables
Function is.rsi.eligible to check for columns that have valid antimicrobial results, but do not have the rsi class yet. Transform the columns of your raw data with: data %>% mutate_if(is.rsi.eligible, as.rsi)
Functions as.mo and is.mo as replacements for as.bactid and is.bactid (since the microoganisms data set not only contains bacteria). These last two functions are deprecated and will be removed in a future release. The as.mo function determines microbial IDs using intelligent rules:
```
as.mo("E. coli")
# [1] B_ESCHR_COL
as.mo("MRSA")
# [1] B_STPHY_AUR
as.mo("S group A")
# [1] B_STRPTC_GRA
```
And with great speed too - on a quite regular Linux server from 2007 it takes us less than 0.02 seconds to transform 25,000 items:
```
thousands_of_E_colis <- rep("E. coli", 25000)
microbenchmark::microbenchmark(as.mo(thousands_of_E_colis), unit = "s")
# Unit: seconds
#         min       median         max  neval
#  0.01817717  0.01843957  0.03878077    100
```
Added parameter reference_df for as.mo, so users can supply their own microbial IDs, name or codes as a reference table
Renamed all previous references to bactid to mo, like:
- Column names inputs of EUCAST_rules, first_isolate and key_antibiotics
- Column names of datasets microorganisms and septic_patients
- All old syntaxes will still work with this version, but will throw warnings
Function labels_rsi_count to print datalabels on a RSI ggplot2 model
Functions as.atc and is.atc to transform/look up antibiotic ATC codes as defined by the WHO. The existing function guess_atc is now an alias of as.atc.
Function ab_property and its aliases: ab_name, ab_tradenames, ab_certe, ab_umcg and ab_trivial_nl
Introduction to AMR as a vignette
Removed clipboard functions as it violated the CRAN policy
Renamed septic_patients$sex to septic_patients$gender

Changed

Added three antimicrobial agents to the antibiotics data set: Terbinafine (D01BA02), Rifaximin (A07AA11) and Isoconazole (D01AC05)

Added 163 trade names to the antibiotics data set, it now contains 298 different trade names in total, e.g.:

ab_official("Bactroban")
# [1] "Mupirocin"
ab_name(c("Bactroban", "Amoxil", "Zithromax", "Floxapen"))
# [1] "Mupirocin" "Amoxicillin" "Azithromycin" "Flucloxacillin"
ab_atc(c("Bactroban", "Amoxil", "Zithromax", "Floxapen"))
# [1] "R01AX06" "J01CA04" "J01FA10" "J01CF05"

For first_isolate, rows will be ignored when there's no species available
Function ratio is now deprecated and will be removed in a future release, as it is not really the scope of this package
Fix for as.mic for values ending in zeroes after a real number
Small fix where B. fragilis would not be found in the microorganisms.umcg data set
Added prevalence column to the microorganisms data set
Added parameters minimum and as_percent to portion_df

Support for quasiquotation in the functions series count_* and portions_*, and n_rsi. This allows to check for more than 2 vectors or columns.

septic_patients %>% select(amox, cipr) %>% count_IR()
# which is the same as:
septic_patients %>% count_IR(amox, cipr)

septic_patients %>% portion_S(amcl)
septic_patients %>% portion_S(amcl, gent)
septic_patients %>% portion_S(amcl, gent, pita)

Edited ggplot_rsi and geom_rsi so they can cope with count_df. The new fun parameter has value portion_df at default, but can be set to count_df.
Fix for ggplot_rsi when the ggplot2 package was not loaded
Added datalabels function labels_rsi_count to ggplot_rsi
Added possibility to set any parameter to geom_rsi (and ggplot_rsi) so you can set your own preferences
Fix for joins, where predefined suffices would not be honoured
Added parameter quote to the freq function
Added generic function diff for frequency tables
Added longest en shortest character length in the frequency table (freq) header of class character

Support for types (classes) list and matrix for freq

my_matrix = with(septic_patients, matrix(c(age, gender), ncol = 2))
freq(my_matrix)

For lists, subsetting is possible:

my_list = list(age = septic_patients$age, gender = septic_patients$gender)
my_list %>% freq(age)
my_list %>% freq(gender)

Other

More unit tests to ensure better integrity of functions

AMR 0.3.0

New

BREAKING: rsi_df was removed in favour of new functions portion_R, portion_IR, portion_I, portion_SI and portion_S to selectively calculate resistance or susceptibility. These functions are 20 to 30 times faster than the old rsi function. The old function still works, but is deprecated.
- New function portion_df to get all portions of S, I and R of a data set with antibiotic columns, with support for grouped variables
BREAKING: the methodology for determining first weighted isolates was changed. The antibiotics that are compared between isolates (call key antibiotics) to include more first isolates (afterwards called first weighted isolates) are now as follows:
- Universal: amoxicillin, amoxicillin/clavlanic acid, cefuroxime, piperacillin/tazobactam, ciprofloxacin, trimethoprim/sulfamethoxazole
- Gram-positive: vancomycin, teicoplanin, tetracycline, erythromycin, oxacillin, rifampicin
- Gram-negative: gentamicin, tobramycin, colistin, cefotaxime, ceftazidime, meropenem
Support for ggplot2
- New functions geom_rsi, facet_rsi, scale_y_percent, scale_rsi_colours and theme_rsi
- New wrapper function ggplot_rsi to apply all above functions on a data set:
  - septic_patients %>% select(tobr, gent) %>% ggplot_rsi will show portions of S, I and R immediately in a pretty plot
  - Support for grouped variables, see ?ggplot_rsi
Determining bacterial ID:
- New functions as.bactid and is.bactid to transform/ look up microbial ID's.
- The existing function guess_bactid is now an alias of as.bactid
- New Becker classification for Staphylococcus to categorise them into Coagulase Negative Staphylococci (CoNS) and Coagulase Positve Staphylococci (CoPS)
- New Lancefield classification for Streptococcus to categorise them into Lancefield groups
For convience, new descriptive statistical functions kurtosis and skewness that are lacking in base R - they are generic functions and have support for vectors, data.frames and matrices
Function g.test to perform the Χ² distributed G-test, which use is the same as chisq.test
~~Function ratio to transform a vector of values to a preset ratio~~
- ~~For example: ratio(c(10, 500, 10), ratio = "1:2:1") would return 130, 260, 130~~
Support for Addins menu in RStudio to quickly insert %in% or %like% (and give them keyboard shortcuts), or to view the datasets that come with this package
Function p.symbol to transform p values to their related symbols: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
Functions clipboard_import and clipboard_export as helper functions to quickly copy and paste from/to software like Excel and SPSS. These functions use the clipr package, but are a little altered to also support headless Linux servers (so you can use it in RStudio Server)
New for frequency tables (function freq):
- A vignette to explain its usage
- Support for rsi (antimicrobial resistance) to use as input
- Support for table to use as input: freq(table(x, y))
- Support for existing functions hist and plot to use a frequency table as input: hist(freq(df$age))
- Support for as.vector, as.data.frame, as_tibble and format
- Support for quasiquotation: freq(mydata, mycolumn) is the same as mydata %>% freq(mycolumn)
- Function top_freq function to return the top/below n items as vector
- Header of frequency tables now also show Mean Absolute Deviaton (MAD) and Interquartile Range (IQR)
- Possibility to globally set the default for the amount of items to print, with options(max.print.freq = n) where n is your preset value

Changed

Improvements for forecasting with resistance_predict and added more examples
More antibiotics added as parameters for EUCAST rules
Updated version of the septic_patients data set to better reflect the reality
Pretty printing for tibbles removed as it is not really the scope of this package
Printing of mic and rsi classes now returns all values - use freq to check distributions
Improved speed of key antibiotics comparison for determining first isolates
Column names for the key_antibiotics function are now generic: 6 for broadspectrum ABs, 6 for Gram-positive specific and 6 for Gram-negative specific ABs
Speed improvement for the abname function
%like% now supports multiple patterns
Frequency tables are now actual data.frames with altered console printing to make it look like a frequency table. Because of this, the parameter toConsole is not longer needed.
Fix for freq where the class of an item would be lost
Small translational improvements to the septic_patients dataset and the column bactid now has the new class "bactid"
Small improvements to the microorganisms dataset (especially for Salmonella) and the column bactid now has the new class "bactid"
Combined MIC/RSI values will now be coerced by the rsi and mic functions:
- as.rsi("<=0.002; S") will return S
- as.mic("<=0.002; S") will return <=0.002
Now possible to coerce MIC values with a space between operator and value, i.e. as.mic("<= 0.002") now works
Classes rsi and mic do not add the attribute package.version anymore
Added "groups" option for atc_property(..., property). It will return a vector of the ATC hierarchy as defined by the WHO. The new function atc_groups is a convenient wrapper around this.
Build-in host check for atc_property as it requires the host set by url to be responsive
Improved first_isolate algorithm to exclude isolates where bacteria ID or genus is unavailable
Fix for warning hybrid evaluation forced for row_number (924b62) from the dplyr package v0.7.5 and above
Support for empty values and for 1 or 2 columns as input for guess_bactid (now called as.bactid)
- So yourdata %>% select(genus, species) %>% as.bactid() now also works
Other small fixes

Other

Added integration tests (check if everything works as expected) for all releases of R 3.1 and higher
- Linux and macOS: https://travis-ci.org/msberends/AMR
- Windows: https://ci.appveyor.com/project/msberends/amr
Added thesis advisors to DESCRIPTION file

AMR 0.2.0

New

Full support for Windows, Linux and macOS
Full support for old R versions, only R-3.0.0 (April 2013) or later is needed (needed packages may have other dependencies)
Function n_rsi to count cases where antibiotic test results were available, to be used in conjunction with dplyr::summarise, see ?rsi
Function guess_bactid to determine the ID of a microorganism based on genus/species or known abbreviations like MRSA
Function guess_atc to determine the ATC of an antibiotic based on name, trade name, or known abbreviations
Function freq to create frequency tables, with additional info in a header
Function MDRO to determine Multi Drug Resistant Organisms (MDRO) with support for country-specific guidelines.
- Exceptional resistances defined by EUCAST are also supported instead of countries alone
- Functions BRMO and MRGN are wrappers for Dutch and German guidelines, respectively
New algorithm to determine weighted isolates, can now be "points" or "keyantibiotics", see ?first_isolate
New print format for tibbles and data.tables

Changed

Fixed rsi class for vectors that contain only invalid antimicrobial interpretations
Renamed dataset ablist to antibiotics
Renamed dataset bactlist to microorganisms
Added common abbreviations and trade names to the antibiotics dataset
Added more microorganisms to the microorganisms dataset
Added analysis examples on help page of dataset septic_patients
Added support for character vector in join functions
Added warnings when a join results in more rows after than before the join
Altered %like% to make it case insensitive
For parameters of functions first_isolate and EUCAST_rules column names are now case-insensitive
Functions as.rsi and as.mic now add the package name and version as attributes

Other

Expanded README.md with more examples
Added ORCID of authors to DESCRIPTION file
Added unit testing with the testthat package
Added build tests for Linux and macOS using Travis CI (https://travis-ci.org/msberends/AMR)
Added line coverage checking using CodeCov (https://codecov.io/gh/msberends/AMR/tree/master/R)

AMR 0.1.1

EUCAST_rules applies for amoxicillin even if ampicillin is missing
Edited column names to comply with GLIMS, the laboratory information system
Added more valid MIC values
Renamed 'Daily Defined Dose' to 'Defined Daily Dose'
Added barplots for rsi and mic classes

AMR 0.1.0

First submission to CRAN.

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